| Year |
Citation |
Score |
| 2023 |
Menon V, Katner SJ, Lee DE, Peterson EJ, Koblinski JE, Farrell NP. Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation. Journal of Inorganic Biochemistry. 252: 112475. PMID 38199050 DOI: 10.1016/j.jinorgbio.2023.112475 |
0.786 |
|
| 2022 |
Rosa NMP, Ferreira FHDC, Farrell NP, Costa LAS. Substitution-inert polynuclear platinum complexes and Glycosaminoglycans: A molecular dynamics study of its non-covalent interactions. Journal of Inorganic Biochemistry. 232: 111811. PMID 35367819 DOI: 10.1016/j.jinorgbio.2022.111811 |
0.318 |
|
| 2022 |
de Paiva REF, Johnson WE, Gorle AK, Berners-Price SJ, Farrell NP. Metalloglycomics of tris(2,2'-bipyridyl) cobalt and ruthenium compounds. Journal of Inorganic Biochemistry. 229: 111731. PMID 35131616 DOI: 10.1016/j.jinorgbio.2022.111731 |
0.359 |
|
| 2020 |
Berners-Price SJ, Gorle AK, Haselhorst T, Katner SJ, Everest-Dass AV, Hampton JD, Peterson EJ, Koblinski JE, Katsuta E, Takabe K, von Itzstein M, Farrell NP. Conformational Modulation of Iduronic Acid-Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound. Implications for Development of Antimetastatic Platinum Drugs. Angewandte Chemie (International Ed. in English). PMID 33174390 DOI: 10.1002/anie.202013749 |
0.302 |
|
| 2020 |
Pinato O, Benettazzo A, Dalla Via L, Farrell NP, Sissi C. Modulation of relaxation activity of human topoisomerases by Pt(II)-based complexes. Journal of Inorganic Biochemistry. 211: 111178. PMID 32712380 DOI: 10.1016/J.Jinorgbio.2020.111178 |
0.419 |
|
| 2020 |
de Paiva REF, Peterson EJ, Du Z, Farrell NP. The leaving group in Au(i)-phosphine compounds dictates cytotoxic pathways in CEM leukemia cells and reactivity towards a CysHis model zinc finger. Dalton Transactions (Cambridge, England : 2003). PMID 32432260 DOI: 10.1039/D0Dt01136C |
0.421 |
|
| 2020 |
Oliveira KM, Peterson EJ, Carroccia MC, Cominetti MR, Deflon VM, Farrell NP, Batista AA, Correa RS. Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer. Dalton Transactions (Cambridge, England : 2003). PMID 32329497 DOI: 10.1039/D0Dt01091J |
0.353 |
|
| 2019 |
Du Z, Qu Y, Farrell NP. Intramolecular platinum migration on a peptide in gas phase during collision-induced dissociation. Journal of Inorganic Biochemistry. 202: 110858. PMID 31689625 DOI: 10.1016/J.Jinorgbio.2019.110858 |
0.32 |
|
| 2019 |
Gorle AK, Berners-Price SJ, Farrell NP. Biological relevance of interaction of platinum drugs with -donor ligands. Inorganica Chimica Acta. 495. PMID 31354168 DOI: 10.1016/J.Ica.2019.118974 |
0.413 |
|
| 2019 |
Rosa NMP, Ferreira FHDC, Farrell NP, Costa LAS. TriplatinNC and Biomolecules: Building Models Based on Non-covalent Interactions. Frontiers in Chemistry. 7: 307. PMID 31231629 DOI: 10.3389/Fchem.2019.00307 |
0.395 |
|
| 2019 |
Yang Y, Dong Z, Hu H, Peng J, Sheng Y, Tong Y, Yuan S, Li Z, Yang J, Wells T, Qu Y, Farrell NP, Liu Y. The facile and visualizable identification of broad-spectrum inhibitors of MDM2/p53 using co-expressed protein complexes. The Analyst. PMID 31089613 DOI: 10.1039/C9An00350A |
0.34 |
|
| 2019 |
Gorle AK, Zhang J, Berners-Price SJ, Farrell NP. Influence of geometric isomerism on the binding of platinum anticancer agents with phospholipids. Dalton Transactions (Cambridge, England : 2003). PMID 31070627 DOI: 10.1039/C9Dt00753A |
0.417 |
|
| 2019 |
Malina J, Čechová K, Farrell NP, Brabec V. Substitution-Inert Polynuclear Platinum Complexes with Dangling Amines: Condensation/Aggregation of Nucleic Acids and Inhibition of DNA-Related Enzymatic Activities. Inorganic Chemistry. PMID 31046253 DOI: 10.1021/Acs.Inorgchem.9B00254 |
0.376 |
|
| 2019 |
Kellett A, Molphy Z, Slator C, McKee V, Farrell NP. Molecular methods for assessment of non-covalent metallodrug-DNA interactions. Chemical Society Reviews. 48: 971-988. PMID 30714595 DOI: 10.1039/C8Cs00157J |
0.377 |
|
| 2019 |
Gorle AK, Rajaratnam P, Chang CW, von Itzstein M, Berners-Price SJ, Farrell NP. Glycans as Ligands in Bioinorganic Chemistry. Probing the Interaction of a Trinuclear Platinum Anticancer Complex with Defined Monosaccharide Fragments of Heparan Sulfate. Inorganic Chemistry. PMID 30632736 DOI: 10.1021/Acs.Inorgchem.8B03035 |
0.379 |
|
| 2019 |
Novakova O, Farrell NP, Brabec V. Translesion DNA synthesis across double-base lesions derived from cross-links of an antitumor trinuclear platinum compound: primer extension, conformational and thermodynamic studies. Metallomics : Integrated Biometal Science. 10: 132-144. PMID 29242879 DOI: 10.1039/C7Mt00266A |
0.416 |
|
| 2019 |
Koblinski JE, Peterson EJ, Hampton JD, Harrell JC, Farrell NP. Abstract C068: Toward precision medicine for platinums Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-C068 |
0.304 |
|
| 2019 |
Dario BS, Neto FF, Portes MC, Fazzi RB, Silva DRd, Peterson EJ, Farrell NP, Castelli S, Desideri A, Petersen PAD, Petrilli HM, Ferreira AMDC. DNA binding, cytotoxic effects and probable targets of an oxindolimine–vanadyl complex as an antitumor agent New Journal of Chemistry. 43: 17831-17840. DOI: 10.1039/C9Nj02480H |
0.446 |
|
| 2018 |
Malina J, Farrell NP, Brabec V. Substitution-Inert Polynuclear Platinum Complexes Act as Potent Inducers of Condensation/Aggregation of Short Single- and Double-Stranded DNA and RNA Oligonucleotides. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30565774 DOI: 10.1002/Chem.201806276 |
0.403 |
|
| 2018 |
Enoque R, Du Z, Nakahata D, Lima F, Corbi P, Farrell NP. Au-catalyzed C-S aryl group transfer in Zinc Finger Proteins. Angewandte Chemie (International Ed. in English). PMID 29870126 DOI: 10.1002/Anie.201803082 |
0.647 |
|
| 2018 |
Malina J, Farrell NP, Brabec V. Substitution-inert polynuclear platinum complexes inhibit activity of DNA polymerase in triplex-forming templates. Angewandte Chemie (International Ed. in English). PMID 29766623 DOI: 10.1002/Anie.201803448 |
0.369 |
|
| 2018 |
Gorle AK, Katner SJ, Johnson WE, Lee DE, Daniel AG, Ginsburg EP, von Itzstein M, Berners-Price SJ, Farrell NP. Substitution-Inert Polynuclear Platinum Complexes as Metalloshielding Agents for Heparan Sulfate. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29655185 DOI: 10.1002/Chem.201706030 |
0.504 |
|
| 2018 |
Katner SJ, Johnson WE, Peterson EJ, Page P, Farrell NP. Comparison of Metal-Ammine Compounds Binding to DNA and Heparin. Glycans as Ligands in Bioinorganic Chemistry. Inorganic Chemistry. PMID 29473748 DOI: 10.1021/acs.inorgchem.7b03043 |
0.302 |
|
| 2018 |
Brabec V, Kasparkova J, Menon V, Farrell NP. Polynuclear Platinum Complexes. Structural Diversity and DNA Binding. Metal Ions in Life Sciences. 18. PMID 29394021 DOI: 10.1515/9783110470734-008 |
0.732 |
|
| 2018 |
Gorle AK, Zhang J, Liu Q, Berners-Price SJ, Farrell NP. Structural factors affecting binding of platinum anticancer agents with phospholipids. Influence of charge and phosphate clamp formation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29341369 DOI: 10.1002/Chem.201705822 |
0.385 |
|
| 2018 |
Abbehausen C, de Paiva REF, Bjornsson R, Gomes SQ, Du Z, Corbi PP, Lima FA, Farrell N. X-ray Absorption Spectroscopy Combined with Time-Dependent Density Functional Theory Elucidates Differential Substitution Pathways of Au(I) and Au(III) with Zinc Fingers. Inorganic Chemistry. 57: 218-230. PMID 29227104 DOI: 10.1021/Acs.Inorgchem.7B02406 |
0.807 |
|
| 2018 |
Katner SJ, Hampton JD, Peterson EJ, Katsuta E, Sayyad MR, Takabe K, Koblinski J, Farrell NP. Abstract 3941: Heparan sulfate, a new target for platinum in metastatic TNBC Cancer Research. 78: 3941-3941. DOI: 10.1158/1538-7445.Am2018-3941 |
0.353 |
|
| 2018 |
de Paula QA, Joly J, Selmeczi K, Fonseca DEP, Caramori GF, Farrell NP, Da Costa Ferreira AM. Binding affinity studies of 1,2,3-triazole copper(II) complexes to human serum albumin Journal of Coordination Chemistry. 71: 1894-1909. DOI: 10.1080/00958972.2018.1495331 |
0.349 |
|
| 2017 |
de Paiva REF, Du Z, Peterson EJ, Corbi PP, Farrell NP. Probing the HIV-1 NCp7 Nucleocapsid Protein with Site-Specific Gold(I)-Phosphine Complexes. Inorganic Chemistry. PMID 28937773 DOI: 10.1021/acs.inorgchem.7b01762 |
0.643 |
|
| 2017 |
Tsotsoros SD, Lutz PB, Daniel AG, Peterson EJ, de Paiva REF, Rivera E, Qu Y, Bayse CA, Farrell NP. Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)](2+) for HIVNCp7 targeting. Chemical Science. 8: 1269-1281. PMID 28451269 DOI: 10.1039/C6Sc03445D |
0.806 |
|
| 2016 |
Bernardes VH, Qu Y, Du Z, Beaton J, Vargas MD, Farrell NP. Interaction of the HIV NCp7 Protein with Platinum(II) and Gold(III) Complexes Containing Tridentate Ligands. Inorganic Chemistry. 55: 11396-11407. PMID 27934299 DOI: 10.1021/Acs.Inorgchem.6B01925 |
0.47 |
|
| 2016 |
Spell SR, Mangrum JB, Peterson EJ, Fabris D, Ptak R, Farrell NP. Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists. Chemical Communications (Cambridge, England). PMID 27858001 DOI: 10.1039/C6Cc07970A |
0.787 |
|
| 2016 |
Brabec V, Kasparkova J, Kostrhunova H, Farrell NP. Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes. Scientific Reports. 6: 28474. PMID 27574114 DOI: 10.1038/Srep28474 |
0.397 |
|
| 2016 |
Abbehausen C, Manzano CM, Corbi PP, Farrell NP. Effects of coordination mode of 2-mercaptothiazoline on reactivity of Au(I) compounds with thiols and sulfur-containing proteins. Journal of Inorganic Biochemistry. PMID 27293145 DOI: 10.1016/J.Jinorgbio.2016.05.011 |
0.822 |
|
| 2016 |
Du Z, de Paiva RE, Qu Y, Farrell N. Tuning the reactivity of Sp1 zinc fingers with platinum complexes. Dalton Transactions (Cambridge, England : 2003). PMID 27171123 DOI: 10.1039/C6Dt01128D |
0.332 |
|
| 2016 |
Komeda S, Qu Y, Mangrum JB, Hegmans A, Williams LD, Farrell NP. The phosphate clamp as recognition motif in platinum-DNA interactions Inorganica Chimica Acta. DOI: 10.1016/J.Ica.2016.04.052 |
0.787 |
|
| 2015 |
Farrell NP. Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets Chemical Society Reviews. 44: 8773-8785. PMID 25951946 DOI: 10.1039/C5Cs00201J |
0.475 |
|
| 2015 |
Spell SR, Farrell NP. [Au(dien)(N-heterocycle)](3+): reactivity with biomolecules and zinc finger peptides. Inorganic Chemistry. 54: 79-86. PMID 25531886 DOI: 10.1021/Ic501784N |
0.804 |
|
| 2015 |
Tsotsoros SD, Qu Y, Farrell NP. The reaction of dichlorodiammineplatinum(II), [PtCl2(NH3)2], isomers with zinc fingers. Journal of Inorganic Biochemistry. 143: 117-22. PMID 25528679 DOI: 10.1016/J.Jinorgbio.2014.12.003 |
0.44 |
|
| 2015 |
Qu Y, Kipping RG, Farrell NP. Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp Dalton Transactions. 44: 3563-3572. PMID 25524170 DOI: 10.1039/C4Dt03237C |
0.479 |
|
| 2015 |
Peterson EJ, Menon VR, Gatti L, Kipping R, Dewasinghe D, Perego P, Povirk LF, Farrell NP. Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction. Molecular Pharmaceutics. 12: 287-97. PMID 25407898 DOI: 10.1021/Mp5006867 |
0.73 |
|
| 2015 |
Moniodis JJ, Thomas DS, Davies MS, Berners-Price SJ, Farrell NP. Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association. Dalton Transactions (Cambridge, England : 2003). 44: 3583-93. PMID 25407024 DOI: 10.1039/c4dt02942a |
0.322 |
|
| 2015 |
Peterson EJ, Berners-Price SJ, Bezos A, Bohlman L, Katner SJ, Daniel AG, Chang C, Itzstein Mv, Parish CR, Farrell NP. Abstract 4486: Antiangiogenic platinum through glycan targeting Cancer Research. 75: 4486-4486. DOI: 10.1158/1538-7445.Am2015-4486 |
0.359 |
|
| 2014 |
Prisecaru A, Molphy Z, Kipping RG, Peterson EJ, Qu Y, Kellett A, Farrell NP. The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes. Nucleic Acids Research. 42: 13474-87. PMID 25414347 DOI: 10.1093/Nar/Gku1157 |
0.457 |
|
| 2014 |
Daniel AG, Farrell NP. The dynamics of zinc sites in proteins: electronic basis for coordination sphere expansion at structural sites. Metallomics : Integrated Biometal Science. 6: 2230-41. PMID 25329367 DOI: 10.1039/c4mt00213j |
0.763 |
|
| 2014 |
Malina J, Farrell NP, Brabec V. Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity. Angewandte Chemie (International Ed. in English). 53: 12812-6. PMID 25256921 DOI: 10.1002/Anie.201408012 |
0.447 |
|
| 2014 |
Cardoso CR, Lima MV, Cheleski J, Peterson EJ, Venâncio T, Farrell NP, Carlos RM. Luminescent ruthenium complexes for theranostic applications. Journal of Medicinal Chemistry. 57: 4906-15. PMID 24831959 DOI: 10.1021/Jm5005946 |
0.354 |
|
| 2014 |
Ma ES, Daniel AG, Farrell NP. Dinuclear platinum complexes containing planar aromatic ligands to enhance stacking interactions with proteins. Chemmedchem. 9: 1155-60. PMID 24801050 DOI: 10.1002/cmdc.201402052 |
0.811 |
|
| 2014 |
Daniel AG, Peterson EJ, Farrell NP. The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3. Angewandte Chemie (International Ed. in English). 53: 4098-101. PMID 24643997 DOI: 10.1002/anie.201311114 |
0.75 |
|
| 2014 |
Mangrum JB, Engelmann BJ, Peterson EJ, Ryan JJ, Berners-Price SJ, Farrell NP. A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding. Chemical Communications (Cambridge, England). 50: 4056-8. PMID 24463939 DOI: 10.1039/C3Cc49695C |
0.781 |
|
| 2014 |
Malina J, Farrell NP, Brabec V. DNA condensing effects and sequence selectivity of DNA binding of antitumor noncovalent polynuclear platinum complexes. Inorganic Chemistry. 53: 1662-71. PMID 24428232 DOI: 10.1021/Ic402796K |
0.439 |
|
| 2014 |
Engelmann BJ, Ryan JJ, Farrell NP. Antidepressants and platinum drugs. Anticancer Research. 34: 509-16. PMID 24403509 |
0.778 |
|
| 2014 |
Spell SR, Farrell NP. Synthesis and properties of the first [Au(dien)(N-heterocycle)]3+ compounds. Inorganic Chemistry. 53: 30-2. PMID 24328316 DOI: 10.1021/Ic402772J |
0.813 |
|
| 2014 |
Tsotsoros SD, Bate AB, Dows MG, Spell SR, Bayse CA, Farrell NP. Modulation of the stacking interaction of MN4 (M=Pt, Pd, Au) complexes with tryptophan through N-heterocyclic ligands. Journal of Inorganic Biochemistry. 132: 2-5. PMID 24206773 DOI: 10.1016/J.Jinorgbio.2013.09.020 |
0.805 |
|
| 2013 |
Menon VR, Peterson EJ, Valerie K, Farrell NP, Povirk LF. Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest. Biochemical Pharmacology. 86: 1708-20. PMID 24161784 DOI: 10.1016/J.Bcp.2013.10.012 |
0.736 |
|
| 2013 |
Abbehausen C, Peterson EJ, de Paiva RE, Corbi PP, Formiga AL, Qu Y, Farrell NP. Gold(I)-phosphine-N-heterocycles: biological activity and specific (ligand) interactions on the C-terminal HIVNCp7 zinc finger. Inorganic Chemistry. 52: 11280-7. PMID 24063530 DOI: 10.1021/Ic401535S |
0.823 |
|
| 2013 |
Madureira J, Ramos CIV, Marques M, Maia C, Sousa Bd, Campino L, Santana-Marques MG, Farrell N. Nonclassic metallointercalators with dipyridophenazine: DNA interaction studies and leishmanicidal activity. Inorganic Chemistry. 52: 8881-8894. PMID 23844713 DOI: 10.1021/Ic401067D |
0.394 |
|
| 2013 |
Mangrum JB, Zgani I, Tsotsoros SD, Qu Y, Farrell NP. Zinc finger peptide cleavage by a dinuclear platinum compound. Chemical Communications (Cambridge, England). 49: 6986-8. PMID 23802199 DOI: 10.1039/C3Cc44219E |
0.768 |
|
| 2013 |
Wedlock LE, Kilburn MR, Liu R, Shaw JA, Berners-Price SJ, Farrell NP. NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound. Chemical Communications (Cambridge, England). 49: 6944-6. PMID 23687657 DOI: 10.1039/C3Cc42098A |
0.37 |
|
| 2013 |
Pinato O, Musetti C, Farrell NP, Sissi C. Platinum-based drugs and proteins: reactivity and relevance to DNA adduct formation. Journal of Inorganic Biochemistry. 122: 27-37. PMID 23435290 DOI: 10.1016/J.Jinorgbio.2013.01.007 |
0.439 |
|
| 2013 |
Neves AP, Pereira MX, Peterson EJ, Kipping R, Vargas MD, Silva-Jr FP, Carneiro JW, Farrell NP. Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes. Journal of Inorganic Biochemistry. 119: 54-64. PMID 23186648 DOI: 10.1016/J.Jinorgbio.2012.10.007 |
0.474 |
|
| 2013 |
Ruhayel RA, Berners-Price SJ, Farrell NP. Competitive formation of both long-range 5'-5' and short-range antiparallel 3'-3' DNA interstrand cross-links by a trinuclear platinum complex on binding to a 10-mer duplex. Dalton Transactions (Cambridge, England : 2003). 42: 3181-7. PMID 23165925 DOI: 10.1039/C2Dt32079G |
0.418 |
|
| 2013 |
Dewkar GK, Jose P, Lamichhane N, Thadigiri C, Sundaresan G, Farrell N, Zweit J. Abstract 4532: Fluorine-18- carboplatin derivative for imaging and therapeutic applications. Cancer Research. 73: 4532-4532. DOI: 10.1158/1538-7445.Am2013-4532 |
0.347 |
|
| 2013 |
Menon V, Peterson E, Deb S, Povirk L, Farrell N. Abstract 3427: The dinuclear platinum agent, BBR3610-DACH, exhibits a significant anti-proliferative effect: Regulation of G1/S and G2/M cell cycle arrest and apoptosis induction. Cancer Research. 73: 3427-3427. DOI: 10.1158/1538-7445.Am2013-3427 |
0.715 |
|
| 2012 |
Silva H, Frézard F, Peterson EJ, Kabolizadeh P, Ryan JJ, Farrell NP. Heparan sulfate proteoglycan-mediated entry pathway for charged tri-platinum compounds: differential cellular accumulation mechanisms for platinum. Molecular Pharmaceutics. 9: 1795-802. PMID 22494465 DOI: 10.1021/Mp300098T |
0.641 |
|
| 2012 |
Frézard F, Silva H, Pimenta AM, Farrell N, Demicheli C. Greater binding affinity of trivalent antimony to a CCCH zinc finger domain compared to a CCHC domain of kinetoplastid proteins. Metallomics : Integrated Biometal Science. 4: 433-40. PMID 22454083 DOI: 10.1039/C2Mt00176D |
0.342 |
|
| 2012 |
Ruhayel RA, Langner JS, Oke MJ, Berners-Price SJ, Zgani I, Farrell NP. Chimeric platinum-polyamines and DNA binding. Kinetics of DNA interstrand cross-link formation by dinuclear platinum complexes with polyamine linkers. Journal of the American Chemical Society. 134: 7135-46. PMID 22443454 DOI: 10.1021/Ja301397H |
0.35 |
|
| 2012 |
Murphy RF, Komlodi-Pasztor E, Robey R, Balis FM, Farrell NP, Fojo T. Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin. Cell Cycle (Georgetown, Tex.). 11: 963-73. PMID 22333583 DOI: 10.4161/Cc.11.5.19447 |
0.394 |
|
| 2012 |
Quintal S, Viegas A, Erhardt S, Cabrita EJ, Farrell NP. Platinated DNA affects zinc finger conformation. Interaction of a platinated single-stranded oligonucleotide and the C-terminal zinc finger of nucleocapsid protein HIVNCp7. Biochemistry. 51: 1752-61. PMID 22303928 DOI: 10.1021/Bi201834G |
0.469 |
|
| 2012 |
Muchova T, Quintal SM, Farrell NP, Brabec V, Kasparkova J. Antitumor bifunctional dinuclear Pt(II) complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 239-45. PMID 21938443 DOI: 10.1007/S00775-011-0845-0 |
0.473 |
|
| 2012 |
Kabolizadeh P, Engelmann BJ, Pullen N, Stewart JK, Ryan JJ, Farrell NP. Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 123-32. PMID 21918844 DOI: 10.1007/S00775-011-0836-1 |
0.796 |
|
| 2012 |
Florian J, Kasparkova J, Farrell NP, Brabec V. Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt(II) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 187-96. PMID 21894503 DOI: 10.1007/S00775-011-0841-4 |
0.385 |
|
| 2012 |
Farrell NP. Progress in platinum-derived drug development Drugs of the Future. 37: 795-806. DOI: 10.1358/Dof.2012.037.011.1830167 |
0.337 |
|
| 2012 |
De Paula QA, Tsotsoros SD, Qu Y, Bayse CA, Farrell NP. Platinum-nucleobase PtN 4 complexes as chemotypes for selective peptide reactions with biomolecules Inorganica Chimica Acta. 393: 222-229. DOI: 10.1016/J.Ica.2012.07.014 |
0.407 |
|
| 2011 |
Demicheli C, Frézard F, Pereira FA, Santos DM, Mangrum JB, Farrell NP. Interaction of arsenite with a zinc finger CCHC peptide: evidence for formation of an As-Zn-peptide mixed complex. Journal of Inorganic Biochemistry. 105: 1753-8. PMID 22099473 DOI: 10.1016/J.Jinorgbio.2011.09.023 |
0.733 |
|
| 2011 |
Benedetti BT, Quintal S, Farrell NP. Modulation of drug activation profiles through carboxylate ligand modification in cytotoxic trans-platinum planar amine compounds. Dalton Transactions (Cambridge, England : 2003). 40: 10983-8. PMID 21918760 DOI: 10.1039/C1Dt10964B |
0.83 |
|
| 2011 |
Malina J, Farrell NP, Brabec V. DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing. Chemistry, An Asian Journal. 6: 1566-74. PMID 21557487 DOI: 10.1002/Asia.201000935 |
0.411 |
|
| 2011 |
Benedetti BT, Peterson EJ, Kabolizadeh P, Martínez A, Kipping R, Farrell NP. Effects of noncovalent platinum drug-protein interactions on drug efficacy: use of fluorescent conjugates as probes for drug metabolism. Molecular Pharmaceutics. 8: 940-8. PMID 21548575 DOI: 10.1021/Mp2000583 |
0.787 |
|
| 2011 |
Musetti C, Nazarov AA, Farrell NP, Sissi C. DNA reactivity profile of trans-platinum planar amine derivatives. Chemmedchem. 6: 1283-90. PMID 21472991 DOI: 10.1002/Cmdc.201100032 |
0.436 |
|
| 2011 |
Ruhayel RA, Zgani I, Berners-Price SJ, Farrell NP. Solution studies of dinuclear polyamine-linked platinum-based antitumour complexes. Dalton Transactions (Cambridge, England : 2003). 40: 4147-54. PMID 21384050 DOI: 10.1039/C1Dt00001B |
0.337 |
|
| 2011 |
Quintal SM, dePaula QA, Farrell NP. Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences. Metallomics : Integrated Biometal Science. 3: 121-39. PMID 21253649 DOI: 10.1039/C0Mt00070A |
0.409 |
|
| 2011 |
Malina J, Kasparkova J, Farrell NP, Brabec V. Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA. Nucleic Acids Research. 39: 720-8. PMID 20833634 DOI: 10.1093/nar/gkq803 |
0.314 |
|
| 2011 |
Komeda S, Moulaei T, Chikuma M, Odani A, Kipping R, Farrell NP, Williams LD. The phosphate clamp: a small and independent motif for nucleic acid backbone recognition. Nucleic Acids Research. 39: 325-36. PMID 20736180 DOI: 10.1093/Nar/Gkq723 |
0.444 |
|
| 2011 |
Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, Bögler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. International Journal of Cancer. 128: 787-96. PMID 20473884 DOI: 10.1002/Ijc.25394 |
0.32 |
|
| 2011 |
Peterson E, Silva H, Menon V, Benedetti B, Kipping R, Farrell N. Abstract C171: TriplatinNC, a nucleolar-targeting platinum agent. Heparan sulfate-mediated cell entry, localization, and apoptosis. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C171 |
0.789 |
|
| 2010 |
Ruhayel RA, Corry B, Braun C, Thomas DS, Berners-Price SJ, Farrell NP. Determination of the kinetic profile of a dinuclear platinum anticancer complex in the presence of sulfate: introducing a new tool for the expedited analysis of 2D [(1)H,( 15)N] HSQC NMR spectra. Inorganic Chemistry. 49: 10815-9. PMID 21067174 DOI: 10.1021/Ic100576K |
0.349 |
|
| 2010 |
Shingu T, Chumbalkar VC, Gwak HS, Fujiwara K, Kondo S, Farrell NP, Bogler O. The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells. Neuro-Oncology. 12: 1269-77. PMID 20713409 DOI: 10.1093/Neuonc/Noq095 |
0.323 |
|
| 2010 |
Mangrum JB, Farrell NP. Excursions in polynuclear platinum DNA binding. Chemical Communications (Cambridge, England). 46: 6640-50. PMID 20694266 DOI: 10.1039/C0Cc01254H |
0.768 |
|
| 2010 |
Montero EI, Zhang J, Moniodis JJ, Berners-Price SJ, Farrell NP. The trans influence in the modulation of platinum anticancer agent biology: the effect of nitrite leaving group on aquation, reactions with S-nucleophiles and DNA binding of dinuclear and trinuclear compounds. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 9175-85. PMID 20589847 DOI: 10.1002/Chem.200903578 |
0.469 |
|
| 2010 |
Zerzankova L, Suchankova T, Vrana O, Farrell NP, Brabec V, Kasparkova J. Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles. Biochemical Pharmacology. 79: 112-21. PMID 19682435 DOI: 10.1016/J.Bcp.2009.08.009 |
0.459 |
|
| 2010 |
Kabolizadeh P, Kipping R, Menon V, Ryan J, Peterson E, Povirk L, Farrell N. Abstract 2494: A non-covalent binding platinum drug, TriplatinNC, induces a G1 phase cell cycle arrest and p53-independent mechanisms of apoptosis Cancer Research. 70: 2494-2494. DOI: 10.1158/1538-7445.Am10-2494 |
0.797 |
|
| 2009 |
Aris SM, Farrell NP. Towards Antitumor Active trans-Platinum Compounds. European Journal of Inorganic Chemistry. 2009: 1293. PMID 20161688 DOI: 10.1002/Ejic.200801118 |
0.828 |
|
| 2009 |
De Paula QA, Liu Q, Almaraz E, Denny JA, Mangrum JB, Bhuvanesh N, Darensbourg MY, Farrell NP. Reactions of palladium and gold complexes with zinc-thiolate chelates using electrospray mass spectrometry and X-ray diffraction: Molecular identification of [Pd(bme-dach)], [Au(bme-dach]+ and [ZnCl(bme-dach)]2Pd Dalton Transactions. 10896-10903. PMID 20023920 DOI: 10.1039/B917748P |
0.753 |
|
| 2009 |
de Paula QA, Mangrum JB, Farrell NP. Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M=Pt, Pd, Au). Journal of Inorganic Biochemistry. 103: 1347-54. PMID 19692125 DOI: 10.1016/J.Jinorgbio.2009.07.002 |
0.779 |
|
| 2009 |
Ruhayel RA, Moniodis JJ, Yang X, Kasparkova J, Brabec V, Berners-Price SJ, Farrell NP. Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: a comparison with the 5'-5' directional isomer. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 9365-74. PMID 19691069 DOI: 10.1002/Chem.200900958 |
0.429 |
|
| 2009 |
Qu Y, Tran MC, Farrell NP. Structural consequences of a 3'-->3' DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 14: 969-77. PMID 19415349 DOI: 10.1007/S00775-009-0509-5 |
0.393 |
|
| 2009 |
Mendoza-Ferri MG, Hartinger CG, Mendoza MA, Groessl M, Egger AE, Eichinger RE, Mangrum JB, Farrell NP, Maruszak M, Bednarski PJ, Klein F, Jakupec MA, Nazarov AA, Severin K, Keppler BK. Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity. Journal of Medicinal Chemistry. 52: 916-25. PMID 19170599 DOI: 10.1021/Jm8013234 |
0.779 |
|
| 2009 |
Aris SM, Knott KM, Yang X, Gewirtz DA, Farrell NP. Modulation of transplanaramine platinum complex reactivity by systematic modification of carrier and leaving groups Inorganica Chimica Acta. 362: 929-934. DOI: 10.1016/J.Ica.2008.01.025 |
0.833 |
|
| 2008 |
Anzellotti AI, Bayse CA, Farrell NP. Effects of nucleobase metalation on frontier molecular orbitals: potential implications for pi-stacking interactions with tryptophan. Inorganic Chemistry. 47: 10425-31. PMID 18939818 DOI: 10.1021/Ic801004A |
0.787 |
|
| 2008 |
Demicheli C, Frézard F, Mangrum JB, Farrell NP. Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs. Chemical Communications (Cambridge, England). 4828-30. PMID 18830507 DOI: 10.1039/B809186B |
0.748 |
|
| 2008 |
Anzellotti AI, Farrell NP. Zinc metalloproteins as medicinal targets. Chemical Society Reviews. 37: 1629-51. PMID 18648687 DOI: 10.1039/B617121B |
0.761 |
|
| 2008 |
Zhang J, Thomas DS, Berners‐Price SJ, Farrell N. Effects of geometric isomerism and anions on the kinetics and mechanism of the stepwise formation of long-range DNA interstrand cross-links by dinuclear platinum antitumor complexes. Chemistry: a European Journal. 14: 6391-6405. PMID 18537208 DOI: 10.1002/Chem.200800408 |
0.406 |
|
| 2008 |
Almaraz E, De Paula QA, Liu Q, Reibenspies JH, Darensbourg MY, Farrell NP. Thiolate bridging and metal exchange in adducts of a zinc finger model and PtII complexes: Biomimetic studies of protein/Pt/DNA interactions Journal of the American Chemical Society. 130: 6272-6280. PMID 18422317 DOI: 10.1021/Ja711254Q |
0.418 |
|
| 2008 |
Hegmans A, Kasparkova J, Vrana O, Kelland LR, Brabec V, Farrell NP. Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity. Journal of Medicinal Chemistry. 51: 2254-60. PMID 18338842 DOI: 10.1021/Jm070813Z |
0.433 |
|
| 2008 |
Strukl JV, De Paula QA, Yang X, Qu Y, Farrell NP. Comparison of cis and trans-platinum mononucleobase compounds with DNA and protein models Australian Journal of Chemistry. 61: 694-699. DOI: 10.1071/Ch08227 |
0.424 |
|
| 2007 |
Montero EI, Benedetti BT, Mangrum JB, Oehlsen MJ, Qu Y, Farrell NP. Pre-association of polynuclear platinum anticancer agents on a protein, human serum albumin. Implications for drug design. Dalton Transactions (Cambridge, England : 2003). 4938-42. PMID 17992278 DOI: 10.1039/B708433C |
0.8 |
|
| 2007 |
Williams JW, Qu Y, Bulluss GH, Alvorado E, Farrell NP. Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand. Inorganic Chemistry. 46: 5820-2. PMID 17592835 DOI: 10.1021/Ic700410Y |
0.397 |
|
| 2007 |
Mitchell C, Kabolizadeh P, Ryan J, Roberts JD, Yacoub A, Curiel DT, Fisher PB, Hagan MP, Farrell NP, Grant S, Dent P. Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. Molecular Pharmacology. 72: 704-14. PMID 17578896 DOI: 10.1124/Mol.107.038406 |
0.63 |
|
| 2007 |
Aris SM, Gewirtz DA, Ryan JJ, Knott KM, Farrell NP. Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes. Biochemical Pharmacology. 73: 1749-57. PMID 17418817 DOI: 10.1016/J.Bcp.2007.02.013 |
0.82 |
|
| 2007 |
Kabolizadeh P, Ryan J, Farrell N. Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([[trans-PtCl(NH3)(2)]2mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis. Biochemical Pharmacology. 73: 1270-9. PMID 17234160 DOI: 10.1016/J.Bcp.2006.12.016 |
0.686 |
|
| 2007 |
Moriarity B, Nováková O, Farrell N, Brabec V, Kašpárková J. 1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin. Archives of Biochemistry and Biophysics. 459: 264-272. PMID 17224122 DOI: 10.1016/J.Abb.2006.11.022 |
0.389 |
|
| 2006 |
Komeda S, Moulaei T, Woods KK, Chikuma M, Farrell NP, Williams LD. A third mode of DNA binding: Phosphate clamps by a polynuclear platinum complex. Journal of the American Chemical Society. 128: 16092-103. PMID 17165762 DOI: 10.1021/Ja062851Y |
0.453 |
|
| 2006 |
Bulluss GH, Knott KM, Ma ES, Aris SM, Alvarado E, Farrell N. trans-Platinum planar amine compounds with [N2O2] ligand donor sets: effects of carboxylate leaving groups and steric hindrance on chemical and biological properties. Inorganic Chemistry. 45: 5733-5. PMID 16841974 DOI: 10.1021/Ic060741M |
0.808 |
|
| 2006 |
Chválová K, Kašpárková J, Farrell N, Brabec V. Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes. Febs Journal. 273: 3467-3478. PMID 16824042 DOI: 10.1111/J.1742-4658.2006.05356.X |
0.436 |
|
| 2006 |
Billecke C, Finniss S, Tahash L, Miller C, Mikkelsen T, Farrell NP, Bögler O. Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma. Neuro-Oncology. 8: 215-26. PMID 16723633 DOI: 10.1215/15228517-2006-004 |
0.346 |
|
| 2006 |
Anzellotti AI, Liu Q, Bloemink MJ, Scarsdale JN, Farrell N. Targeting retroviral Zn finger-DNA interactions: a small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds. Chemistry & Biology. 13: 539-48. PMID 16720275 DOI: 10.1016/J.Chembiol.2006.04.004 |
0.799 |
|
| 2006 |
Liu Q, Qu Y, Van Antwerpen R, Farrell N. Mechanism of the membrane interaction of polynuclear platinum anticancer agents. Implications for cellular uptake. Biochemistry. 45: 4248-56. PMID 16566599 DOI: 10.1021/Bi052517Z |
0.443 |
|
| 2006 |
Anzellotti AI, Sabat M, Farrell N. Covalent and noncovalent interactions for [metal(dien)nucleobase](2+) complexes with L-tryptophan derivatives: formation of palladium-tryptophan species by nucleobase substitution under biologically relevant conditions. Inorganic Chemistry. 45: 1638-45. PMID 16471976 DOI: 10.1021/Ic051644G |
0.791 |
|
| 2006 |
Quiroga AG, Pérez JM, Alonso C, Navarro-Ranninger C, Farrell N. Novel transplatinum(II) complexes with [N2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells. Journal of Medicinal Chemistry. 49: 224-31. PMID 16392807 DOI: 10.1021/Jm050804V |
0.352 |
|
| 2006 |
Harris AL, Ryan JJ, Farrell N. Biological consequences of trinuclear platinum complexes: comparison of [[trans-PtCl(NH3)2]2mu-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ (BBR 3464) with its noncovalent congeners. Molecular Pharmacology. 69: 666-72. PMID 16275707 DOI: 10.1124/Mol.105.018762 |
0.518 |
|
| 2006 |
Billecke C, Malik I, Movsisyan A, Sulghani S, Sharif A, Mikkelsen T, Farrell NP, Bögler O. Analysis of glioma cell platinum response by metacomparison of two-dimensional chromatographic proteome profiles. Molecular & Cellular Proteomics : McP. 5: 35-42. PMID 15951525 DOI: 10.1074/Mcp.M500124-Mcp200 |
0.308 |
|
| 2006 |
Anzellotti A, Stefan S, Gibson D, Farrell N. Donor atom preferences in substitution reactions of trans-platinum mononucleobase compounds : Implications for DNA-protein selectivity Inorganica Chimica Acta. 359: 3014-3019. DOI: 10.1016/J.Ica.2005.12.060 |
0.457 |
|
| 2005 |
Harris AL, Yang X, Hegmans A, Povirk L, Ryan JJ, Kelland L, Farrell NP. Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge. Inorganic Chemistry. 44: 9598-600. PMID 16363817 DOI: 10.1021/Ic051390Z |
0.384 |
|
| 2005 |
Marini V, Christofis P, Novakova O, Kasparkova J, Farrell N, Brabec V. Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)]. Nucleic Acids Research. 33: 5819-5828. PMID 16237123 DOI: 10.1093/Nar/Gki884 |
0.422 |
|
| 2005 |
Ma ES, Bates WD, Edmunds A, Kelland LR, Fojo T, Farrell N. Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile. Journal of Medicinal Chemistry. 48: 5651-4. PMID 16134932 DOI: 10.1021/Jm050539D |
0.434 |
|
| 2005 |
Liu Q, Golden M, Darensbourg MY, Farrell N. Thiolate-bridged heterodinuclear platinum-zinc chelates as models for ternary platinum-DNA-protein complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-mass spectrometry Chemical Communications. 4360-4362. PMID 16113748 DOI: 10.1039/B507751F |
0.397 |
|
| 2005 |
Oehlsen ME, Hegmans A, Qu Y, Farrell N. Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 433-42. PMID 16091934 DOI: 10.1007/S00775-005-0009-1 |
0.805 |
|
| 2005 |
Ourliac-Garnier I, Elizondo-Riojas MA, Redon S, Farrell NP, Bombard S. Cross-links of quadruplex structures from human telomeric DNA by dinuclear platinum complexes show the flexibility of both structures. Biochemistry. 44: 10620-34. PMID 16060671 DOI: 10.1021/Bi050144W |
0.375 |
|
| 2005 |
Quintal SM, Qu Y, Quiroga AG, Moniodis J, Nogueira HI, Farrell N. Pyridine-carboxylate complexes of platinum. Effect of N,O-chelate formation on model bifunctional DNA-DNA and DNA-protein interactions. Inorganic Chemistry. 44: 5247-53. PMID 16022522 DOI: 10.1021/Ic050062W |
0.42 |
|
| 2005 |
Oehlsen ME, Hegmans A, Qu Y, Farrell N. A surprisingly stable macrochelate formed from the reaction of cis dinuclear platinum antitumor compounds with reduced glutathione. Inorganic Chemistry. 44: 3004-6. PMID 15847402 DOI: 10.1021/Ic0501972 |
0.805 |
|
| 2005 |
Harris A, Qu Y, Farrell N. Unique cooperative binding interaction observed between a minor groove binding Pt antitumor agent and Hoechst dye 33258. Inorganic Chemistry. 44: 1196-8. PMID 15732956 DOI: 10.1021/Ic048356P |
0.421 |
|
| 2005 |
Anzellotti AI, Ma ES, Farrell N. Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes. Inorganic Chemistry. 44: 483-5. PMID 15679374 DOI: 10.1021/Ic049086D |
0.801 |
|
| 2005 |
Muggia F, Farrell N. Platinum coordination compounds in cancer chemotherapy Critical Reviews in Oncology/Hematology. 53: 1-2. DOI: 10.1016/J.Critrevonc.2004.11.007 |
0.341 |
|
| 2004 |
Farrell NP. Preclinical perspectives on the use of platinum compounds in cancer chemotherapy. Seminars in Oncology. 31: 1-9. PMID 15726528 DOI: 10.1053/J.Seminoncol.2004.11.004 |
0.389 |
|
| 2004 |
Kasparkova J, Fojta M, Farrell N, Brabec V. Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin. Nucleic Acids Research. 32: 5546-52. PMID 15486204 DOI: 10.1093/Nar/Gkh896 |
0.405 |
|
| 2004 |
Berners-Price S, Farrell N. The Ninth International Symposium on Platinum Compounds in Cancer Chemotherapy Journal of Inorganic Biochemistry. 98. PMID 15458829 DOI: 10.1016/S0162-0134(04)00247-8 |
0.318 |
|
| 2004 |
Qu Y, Harris A, Hegmans A, Petz A, Kabolizadeh P, Penazova H, Farrell N. Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes. Journal of Inorganic Biochemistry. 98: 1591-8. PMID 15458821 DOI: 10.1016/J.Jinorgbio.2004.07.012 |
0.729 |
|
| 2004 |
Qu Y, Scarsdale NJ, Tran MC, Farrell N. Comparison of structural effects in 1,4 DNA-DNA interstrand cross-links formed by dinuclear and trinuclear platinum complexes. Journal of Inorganic Biochemistry. 98: 1585-90. PMID 15458820 DOI: 10.1016/J.Jinorgbio.2004.07.011 |
0.45 |
|
| 2004 |
Kasparkova J, Vrana O, Farrell N, Brabec V. Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding. Journal of Inorganic Biochemistry. 98: 1560-9. PMID 15458817 DOI: 10.1016/J.Jinorgbio.2004.04.019 |
0.367 |
|
| 2004 |
Farrell N, Povirk LF, Dange Y, DeMasters G, Gupta MS, Kohlhagen G, Khan QA, Pommier Y, Gewirtz DA. Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells. Biochemical Pharmacology. 68: 857-66. PMID 15294448 DOI: 10.1016/J.Bcp.2004.05.023 |
0.406 |
|
| 2004 |
Kloster M, Kostrhunova H, Zaludova R, Malina J, Kasparkova J, Brabec V, Farrell N. Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents. Biochemistry. 43: 7776-86. PMID 15196020 DOI: 10.1021/Bi030243E |
0.465 |
|
| 2003 |
Oehlsen ME, Qu Y, Farrell N. Reaction of polynuclear platinum antitumor compounds with reduced glutathione studied by multinuclear (1H, 1H-15N gradient heteronuclear single-quantum coherence, and 195Pt) NMR spectroscopy. Inorganic Chemistry. 42: 5498-506. PMID 12950196 DOI: 10.1021/Ic030045B |
0.799 |
|
| 2003 |
Kasparkova J, Novakova O, Farrell N, Brabec V. DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts. Biochemistry. 42: 792-800. PMID 12534292 DOI: 10.1021/Bi026614T |
0.495 |
|
| 2003 |
Najajreh Y, Peleg-Shulman T, Moshel O, Farrell N, Gibson D. Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins. Journal of Biological Inorganic Chemistry. 8: 167-175. PMID 12459912 DOI: 10.1007/S00775-002-0402-Y |
0.423 |
|
| 2003 |
Qu Y, Scarsdale NJ, Tran MC, Farrell NP. Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 8: 19-28. PMID 12459895 DOI: 10.1007/S00775-002-0383-X |
0.474 |
|
| 2003 |
Thomas DS, Davies MS, Zhang J, Berners-Price SJ, Farrell N. NMR studies probing the directionality of DNA interstrand cross-linking by the trinuclear platinum complex BBR3464 Journal of Inorganic Biochemistry. 96: 239. DOI: 10.1016/S0162-0134(03)80785-7 |
0.368 |
|
| 2002 |
Kasparkova J, Zehnulova J, Farrell N, Brabec V. DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair. The Journal of Biological Chemistry. 277: 48076-86. PMID 12226099 DOI: 10.1074/jbc.M208016200 |
0.342 |
|
| 2002 |
McGregor TD, Bousfield W, Qu Y, Farrell N. Circular dichroism study of the irreversibility of conformational changes induced by polyamine-linked dinuclear platinum compounds. Journal of Inorganic Biochemistry. 91: 212-9. PMID 12121778 DOI: 10.1016/S0162-0134(02)00398-7 |
0.821 |
|
| 2002 |
McGregor TD, Hegmans A, Kaspárková J, Neplechová K, Nováková O, Penazová H, Vrána O, Brabec V, Farrell N. A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 7: 397-404. PMID 11941497 DOI: 10.1007/S00775-001-0312-4 |
0.832 |
|
| 2001 |
Qu Y, Fitzgerald JA, Rauter H, Farrell N. Approaches to selective DNA binding in polyfunctional dinuclear platinum chemistry. The synthesis of a trifunctional compound and its interaction with the mononucleotide 5'-guanosine monophosphate. Inorganic Chemistry. 40: 6324-7. PMID 11703138 DOI: 10.1021/Ic010584L |
0.418 |
|
| 2001 |
Hegmans A, Qu Y, Kelland LR, Roberts JD, Farrell N. Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates. Inorganic Chemistry. 40: 6108-6114. PMID 11703107 DOI: 10.1021/Ic010509A |
0.376 |
|
| 2001 |
Cox JW, Berners-Price SJ, Davies MS, Qu Y, Farrell N. Kinetic analysis of the stepwise formation of a long-range DNA interstrand cross-link by a dinuclear platinum antitumor complex: evidence for aquated intermediates and formation of both kinetically and thermodynamically controlled conformers. Journal of the American Chemical Society. 123: 1316-26. PMID 11456703 DOI: 10.1021/Ja0012772 |
0.408 |
|
| 2001 |
Hofr C, Farrell N, Brabec V. Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex Nucleic Acids Research. 29: 2034-2040. PMID 11353072 DOI: 10.1093/Nar/29.10.2034 |
0.394 |
|
| 2001 |
Fontes APS, Oskarsson Å, Lövqvist K, Farrell N. Synthesis, characterization, and reactivity of trans-[PtCl(R'R''SO)(A)2]NO3 (R'R''SO = Me2SO, MeBzSO, MePhSO; A= NH3, py, pic). Crystal structure of trans-[PtCl(Me2SO)(py)2]+. Inorganic Chemistry. 40: 1745-1750. PMID 11312728 DOI: 10.1021/Ic000107N |
0.357 |
|
| 2000 |
Davies MS, Cox JW, Berners-Price SJ, Barklage W, Qu Y, Farrell N. Equilibrium and kinetic studies of the aquation of the dinuclear platinum complex [[trans-PtCl(NH3)2]2(mu-NH2(CH2)6NH2)]2+: pKa determinations of aqua ligands via [1H,15N] NMR spectroscopy. Inorganic Chemistry. 39: 1710-5. PMID 12526558 DOI: 10.1021/Ic991104H |
0.369 |
|
| 2000 |
Bierbach U, Sabat M, Farrell N. Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum(II) complexes containing the bidentate N,O-donor pyridin-2-yl-acetate. Inorganic Chemistry. 39: 1882-90. PMID 11428108 DOI: 10.1021/Ic991259P |
0.704 |
|
| 2000 |
Sartori DA, Miller B, Bierbach U, Farrell N. Modulation of the chemical and biological properties of trans platinum complexes: Monofunctional platinum complexes containing one nucleobase as potential antiviral chemotypes Journal of Biological Inorganic Chemistry. 5: 575-583. PMID 11085648 DOI: 10.1007/S007750000113 |
0.672 |
|
| 2000 |
Qu Y, Rauter H, Fontes APS, Bandarage R, Kelland LR, Farrell N. Synthesis, characterization, and cytotoxicity of trifunctional dinuclear platinum complexes: comparison of effects of geometry and polyfunctionality on biological activity. Journal of Medicinal Chemistry. 43: 3189-3192. PMID 10956227 DOI: 10.1021/Jm990536Z |
0.43 |
|
| 2000 |
Brabec V, Neplechova K, Kasparkova J, Farrell N. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups. Journal of Biological Inorganic Chemistry. 5: 364-368. PMID 10907747 DOI: 10.1007/Pl00010665 |
0.47 |
|
| 2000 |
Lemma K, Berglund J, Farrell N, Elding LI. Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 5: 300-6. PMID 10907740 DOI: 10.1007/Pl00010658 |
0.44 |
|
| 1999 |
Bierbach U, Qu Y, Hambley TW, Peroutka J, Nguyen HL, Doedee M, Farrell N. Synthesis, Structure, Biological Activity, and DNA Binding of Platinum(II) Complexes of the Type trans-[PtCl(2)(NH(3))L] (L = Planar Nitrogen Base). Effect of L and Cis/Trans Isomerism on Sequence Specificity and Unwinding Properties Observed in Globally Platinated DNA. Inorganic Chemistry. 38: 3535-3542. PMID 11671101 DOI: 10.1021/Ic981181X |
0.681 |
|
| 1999 |
Perego P, Gatti L, Caserini C, Supino R, Colangelo D, Leone R, Spinelli S, Farrell N, Zunino F. The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells. Journal of Inorganic Biochemistry. 77: 59-64. PMID 10626355 DOI: 10.1016/S0162-0134(99)00142-7 |
0.42 |
|
| 1999 |
Roberts JD, Peroutka J, Farrell N. Cellular pharmacology of polynuclear platinum anti-cancer agents. Journal of Inorganic Biochemistry. 77: 51-57. PMID 10626354 DOI: 10.1016/S0162-0134(99)00147-6 |
0.447 |
|
| 1999 |
Roberts JD, Peroutka J, Beggiolin G, Manzotti C, Piazzoni L, Farrell N. Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines. Journal of Inorganic Biochemistry. 77: 47-50. PMID 10626353 DOI: 10.1016/S0162-0134(99)00137-3 |
0.433 |
|
| 1999 |
McGregor TD, Balcarová Z, Qu Y, Tran MC, Zaludová R, Brabec V, Farrell N. Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes Journal of Inorganic Biochemistry. 77: 43-46. PMID 10626352 DOI: 10.1016/S0162-0134(99)00136-1 |
0.813 |
|
| 1999 |
Kloster MB, Hannis JC, Muddiman DC, Farrell N. Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug. Biochemistry. 38: 14731-7. PMID 10555954 DOI: 10.1021/Bi991202E |
0.414 |
|
| 1999 |
Pratesi G, Perego P, Polizzi D, Righetti SC, Supino R, Caserini C, Manzotti C, Giuliani FC, Pezzoni G, Tognella S, Spinelli S, Farrell N, Zunino F. A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: Hypersensitivity of p53-mutant human tumour xenografts British Journal of Cancer. 80: 1912-1919. PMID 10471039 DOI: 10.1038/Sj.Bjc.6690620 |
0.392 |
|
| 1999 |
Kašpárková J, Nováková O, Vrána O, Farrell N, Brabec V. Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking. Biochemistry. 38: 10997-11005. PMID 10460154 DOI: 10.1021/Bi990245S |
0.396 |
|
| 1999 |
Brabec V, Kašpárková J, Vrána O, Nováková O, Cox JW, Qu Y, Farrell N. DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent. Biochemistry. 38: 6781-6790. PMID 10346899 DOI: 10.1021/Bi990124S |
0.418 |
|
| 1998 |
Žákovská A, Nováková O, Balcarová Z, Bierbach U, Farrell N, Brabec V. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)] European Journal of Biochemistry. 254: 547-557. PMID 9688265 DOI: 10.1046/J.1432-1327.1998.2540547.X |
0.707 |
|
| 1998 |
Schaaff TG, Qu Y, Farrell N, Wysocki VH. Investigation of the trans effect in the fragmentation of dinuclear platinum complexes by electrospray ionization surface-induced dissociation tandem mass spectrometry. Journal of Mass Spectrometry : Jms. 33: 436-43. PMID 9615417 DOI: 10.1002/(Sici)1096-9888(199805)33:5<436::Aid-Jms649>3.0.Co;2-K |
0.404 |
|
| 1998 |
Skov KA, Adomat H, Farrell NP, Matthews JB. Assessment of toxicity of bis-platinum complexes in hypoxic and aerobic cells Anti-Cancer Drug Design. 13: 207-220. PMID 9595034 |
0.318 |
|
| 1998 |
Bierbach U, Roberts JD, Farrell N. Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3and [{PtCl(diamine)}2(L-L)](NO3)2(L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity Inorganic Chemistry. 37: 717-723. DOI: 10.1021/Ic970421Q |
0.703 |
|
| 1998 |
Bierbach U, Hambley TW, Farrell N. Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 1. Synthesis, Structure, and Spectroscopic Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3and [{PtCl(diamine)}2(L-L)](NO3)2(L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) Inorganic Chemistry. 37: 708-716. DOI: 10.1021/Ic970420Y |
0.696 |
|
| 1998 |
Bierbach U, Farrell N. Structural and reactivity studies on the ternary system guanine/methionine/trans-[PtCl2(NH3)L] (L = NH3, quinoline): Implications for the mechanism of action of nonclassical trans-platinum antitumor complexes Journal of Biological Inorganic Chemistry. 3: 570-580. DOI: 10.1007/S007750050270 |
0.702 |
|
| 1997 |
Bierbach U, Farrell N. Modulation of Nucleotide Binding of trans Platinum(II) Complexes by Planar Ligands. A Combined Proton NMR and Molecular Mechanics Study. Inorganic Chemistry. 36: 3657-3665. PMID 11670057 DOI: 10.1021/Ic970154O |
0.705 |
|
| 1997 |
Žaludová R, Žákovská A, Kašpárková J, Balcarová Z, Kleinwächter V, Vrana O, Farrell N, Brabec V. DNA Interactions of Bifunctional Dinuclear Platinum(II) Antitumor Agents Febs Journal. 246: 508-517. PMID 9208945 DOI: 10.1111/J.1432-1033.1997.00508.X |
0.391 |
|
| 1997 |
Mellish KJ, Qu Y, Scarsdale N, Farrell N. Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides Nucleic Acids Research. 25: 1265-1271. PMID 9092638 DOI: 10.1093/Nar/25.6.1265 |
0.383 |
|
| 1997 |
Rauter H, Domenico RD, Menta E, Oliva A, Qu aY, Farrell N. Selective Platination of Biologically Relevant Polyamines. Linear Coordinating Spermidine and Spermine as Amplifying Linkers in Dinuclear Platinum Complexes Inorganic Chemistry. 36: 3919-3927. DOI: 10.1021/Ic9701827 |
0.408 |
|
| 1997 |
Qu Y, Farrell N, Kasparkova J, Brabec V. DNA binding of properties of trinuclear platinum complex Journal of Inorganic Biochemistry. 67: 174. DOI: 10.1016/S0162-0134(97)80052-9 |
0.369 |
|
| 1997 |
Kharatishvili M, Mathieson M, Farrell N. Effects Of Quinoline As Ligand In Binding Of Mononuclear And Dinuclear Platinum Complexes To Dna Inorganica Chimica Acta. 255: 1-6. DOI: 10.1016/S0020-1693(96)05196-1 |
0.469 |
|
| 1996 |
Bierbach U, Hambley TW, Roberts JD, Farrell N. Oxidative Addition of the Dithiobis(formamidinium) Cation to Platinum(II) Chloro Am(m)ine Compounds: Studies on Structure, Spectroscopic Properties, Reactivity, and Cytotoxicity of a New Class of Platinum(IV) Complexes Exhibiting S-Thiourea Coordination. Inorganic Chemistry. 35: 4865-4872. PMID 11666686 DOI: 10.1021/Ic960314G |
0.702 |
|
| 1996 |
Wu PK, Kharatishvili M, Qu Y, Farrell N. A circular dichroism study of ethidium bromide binding to Z-DNA induced by dinuclear platinum complexes Journal of Inorganic Biochemistry. 63: 9-18. PMID 8699175 DOI: 10.1016/0162-0134(95)00163-8 |
0.421 |
|
| 1996 |
Farrell N, Appleton TG, Qu Y, Roberts JD, Fontes AP, Skov KA, Wu P, Zou Y. Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA. Biochemistry. 34: 15480-6. PMID 7492537 DOI: 10.1021/Bi00047A013 |
0.456 |
|
| 1996 |
Qu Y, Bloemink MJ, Reedijk J, Hambley TW, Farrell N. Dinuclear Platinum Complexes Form a Novel Intrastrand Adduct with d(GpG), an anti−syn Conformation of the Macrochelate As Observed by NMR and Molecular Modeling Journal of the American Chemical Society. 118: 9307-9313. DOI: 10.1021/Ja961823K |
0.539 |
|
| 1996 |
Qu Y, Farrell N. Association of mononuclear and dinuclear platinum tetraamine cations with nucleotides studied by 15N NMR relaxation Inorganica Chimica Acta. 245: 265-267. DOI: 10.1016/0020-1693(95)04815-4 |
0.417 |
|
| 1995 |
Bernareggi A, Torti L, Facino RM, Carini M, Depta G, Casetta B, Farrell N, Spadacini S, Ceserani R, Tognella S. Characterization of cisplatin-glutathione adducts by liquid chromatography-mass spectrometry evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats and cancer patients Journal of Chromatography B: Biomedical Sciences and Applications. 669: 247-263. PMID 7581901 DOI: 10.1016/0378-4347(95)00098-4 |
0.307 |
|
| 1995 |
Qu Y, Farrell N. Synthesis and Chemical Properties of a Heterodinuclear (Pt,Ru) DNA-DNA and DNA-Protein Crosslinking Agent Inorganic Chemistry. 34: 3573-3576. DOI: 10.1021/Ic00117A033 |
0.43 |
|
| 1995 |
Farrell N, Peroutka J, Qu Y, Roberts JD. Protein-associated DNA strand breaks from novel transplatinum complexes containing planar amines Journal of Inorganic Biochemistry. 59: 232. DOI: 10.1016/0162-0134(95)97338-Q |
0.373 |
|
| 1994 |
Zou Y, Houten BV, Farrell N. Sequence specificity of DNA-DNA interstrand cross-link formation by cisplatin and dinuclear platinum complexes. Biochemistry. 33: 5404-5410. PMID 8180163 DOI: 10.1021/Bi00184A007 |
0.352 |
|
| 1994 |
Wu PK, Qu Y, Van Houten B, Farrell N. Chemical reactivity and DNA sequence specificity of formally monofunctional and bifunctional bis(platinum) complexes. Journal of Inorganic Biochemistry. 54: 207-20. PMID 8027742 DOI: 10.1016/0162-0134(94)80014-6 |
0.421 |
|
| 1994 |
Fontes APS, Zou Y, Farrell N. Synthesis of functionalized platinum complexes containing dimethylsulfoxide as leaving group. Observation of novel steric control of intrastrand versus interstrand cross-linking by use of bulky ligands Journal of Inorganic Biochemistry. 55: 79-85. DOI: 10.1016/0162-0134(94)85030-5 |
0.437 |
|
| 1993 |
Farrell N. Nonclassical Platinum Antitumor Agents: Perspectives for Design and Development of New Drugs Complementary to Cisplatin Cancer Investigation. 11: 578-589. PMID 8402226 DOI: 10.3109/07357909309011676 |
0.425 |
|
| 1993 |
Van Houten B, Illenye S, Qu Y, Farrell N. Homodinuclear (Pt,Pt) and heterodinuclear (Ru,Pt) metal compounds as DNA-protein cross-linking agents: potential suicide DNA lesions. Biochemistry. 32: 11794-801. PMID 8218250 DOI: 10.1021/Bi00095A007 |
0.412 |
|
| 1993 |
Skov KA, Adomat H, Farrell NP. Radiosensitization by nickel lapachol International Journal of Radiation Biology. 64: 707-713. PMID 7903338 DOI: 10.1080/09553009314551951 |
0.358 |
|
| 1993 |
Rochon FD, Melanson R, Farrell N. Structures of the nitroimidazole platinum group metal complexes cis -amminedibromo[1-({[(2-hydroxyethyl)amino]carbonyl}methyl)-2-nitroimidazole]platinum(II) and trans -dichlorobis(1-hydroxyethyl-2-methyl-5-nitroimidazole)palladium(II) Acta Crystallographica Section C-Crystal Structure Communications. 49: 1703-1706. DOI: 10.1107/S0108270193002537 |
0.36 |
|
| 1993 |
Qu Y, Appleton TG, Hoeschele JD, Farrell N. Cisplatin as a synthon. Synthesis and characterization of triplatinum complexes containing three cis-Pt(amine)2 units linked in a linear fashion Inorganic Chemistry. 32: 2591-2593. DOI: 10.1021/Ic00063A063 |
0.372 |
|
| 1993 |
Qu Y, Farrell N, Valsecchi M, Greco Ld, Spinelli S. Multinuclear 195Pt and 15N magnetic resonance spectroscopic studies of the reaction of K[PtCl3(NH3)] with KI and amines Magnetic Resonance in Chemistry. 31: 920-924. DOI: 10.1002/Mrc.1260311009 |
0.412 |
|
| 1992 |
Johnson A, Qu Y, Van Houten B, Farrell N. B----Z DNA conformational changes induced by a family of dinuclear bis(platinum) complexes. Nucleic Acids Research. 20: 1697-703. PMID 1579462 DOI: 10.1093/Nar/20.7.1697 |
0.386 |
|
| 1992 |
Kraker AJ, Hoeschele JD, Elliott WL, Showalter HD, Sercel AD, Farrell NP. Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups. Journal of Medicinal Chemistry. 35: 4526-32. PMID 1335074 DOI: 10.1021/Jm00102A003 |
0.403 |
|
| 1992 |
Bloemink MJ, Reedijk J, Farrell N, Qu Y, Stetsenko AI. The dinuclear complex [{trans-PtCl(NH3)2}2{µ-H2N(CH2)6NH2}]Cl2 forms a unique macrochelate intrastrand crosslink with d(GpG) Journal of the Chemical Society, Chemical Communications. 1002-1003. DOI: 10.1039/C39920001002 |
0.484 |
|
| 1992 |
Qu Y, Farrell N. The product of the reaction of trans-diamminedichloroplatinum(II) with diamines is dependent on chain length. Example of a bridging ethylenediamine and formation of a novel trans-chelated structure with 1,5-pentanediamine Inorganic Chemistry. 31: 930-932. DOI: 10.1021/Ic00031A043 |
0.314 |
|
| 1992 |
Beusichem MV, Farrell N. Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole and quinoline. Crystal and molecular structure of trans-dichlorobis (thiazole)platinum(II) Inorganic Chemistry. 31: 634-639. DOI: 10.1021/Ic00030A021 |
0.442 |
|
| 1992 |
Qu Y, Almeida SGd, Farrell N. Synthetic strategies for dinuclear platinum complexes containing inequivalent coordination spheres. Design of complexes capable of specific attack at one platinum center Inorganica Chimica Acta. 201: 123-129. DOI: 10.1016/S0020-1693(00)85322-0 |
0.423 |
|
| 1992 |
Almeida SGd, Hubbard JL, Farrell N. Spectroscopic and structural properties of dimethyl-, diphenyl- and methylphenylsulfoxide platinum complexes. The crystal and molecular structures of cis-dichlorobis(methylphenylsulfoxide)-platinum(II) and potassiumtrichloro(phenylsulfoxide)platinum(II)-acetone solvate Inorganica Chimica Acta. 193: 149-157. DOI: 10.1016/S0020-1693(00)80346-1 |
0.343 |
|
| 1991 |
Farrell N, Roberts JD, Hacker MP. Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato) platinum(II). Evidence for a novel rearrangement involving platinum-carbon bond formation. Journal of Inorganic Biochemistry. 42: 237-246. PMID 1880505 DOI: 10.1016/0162-0134(91)84038-B |
0.337 |
|
| 1991 |
Qu Y, Farrell N. Interaction of bis(platinum) complexes with the mononucleotide 5'-guanosine monophosphate. Effect of diamine linker and the nature of the bis(platinum) complex on product formation Journal of the American Chemical Society. 113: 4851-4857. DOI: 10.1021/Ja00013A021 |
0.431 |
|
| 1991 |
Rochon FD, Kong PC, Melanson R, Skov KA, Farrell N. Characterization and properties of monoammine nitroimidazole complexes of platinum [PtCl2(NH3)(NO2Im)]. Crystal and molecular structure of cis-amminedichloro(1-{(((2-hydroxyethyl)amino)carbonyl)methyl}-2-nitroimidazole)platinum(II) Inorganic Chemistry. 30: 4531-4535. DOI: 10.1021/Ic00024A013 |
0.369 |
|
| 1991 |
Hoeschele JD, Kraker AJ, Sercel AD, Showalter HDH, Elliott WL, Farrell NP. Synthesis and antitumor activity of bis-platinum complexes varying in the nature of the bridging diamine linker group. Journal of Inorganic Biochemistry. 43: 606. DOI: 10.1016/0162-0134(91)84577-V |
0.345 |
|
| 1991 |
Beusichem Mv, Fontes APS, Roberts JD, Kelland LR, Farrell N. Activation of the trans geometry in platinum antitumor complexes. Journal of Inorganic Biochemistry. 43: 602. DOI: 10.1016/0162-0134(91)84573-R |
0.353 |
|
| 1990 |
Farrell N, Qu Y, Hacker MP. Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes Journal of Medicinal Chemistry. 33: 2179-2184. PMID 2374143 DOI: 10.1021/Jm00170A021 |
0.417 |
|
| 1990 |
Farrell N, Qu Y, Feng L, Houten BV. Comparison of chemical reactivity, cytotoxicity, interstrand cross-linking and DNA sequence specificity of bis(platinum) complexes containing monodentate or bidentate coordination spheres with their monomeric analogues. Biochemistry. 29: 9522-9531. PMID 2271599 DOI: 10.1021/Bi00493A005 |
0.423 |
|
| 1990 |
Skov KA, Adomat H, Chaplin DJ, Farrell NP. Toxicity of [PtCl2(NH3)L] in hypoxia; L=misonidazole or metronidazole Anti-Cancer Drug Design. 5: 121-128. PMID 2156514 |
0.305 |
|
| 1990 |
Skov KA, Farrell NP. Radiosensitization by metal complexes of 4(5)-nitroimidazole International Journal of Radiation Biology. 57: 947-958. PMID 1970996 DOI: 10.1080/09553009014551071 |
0.312 |
|
| 1990 |
Farrell N, Kiley DM, Schmidt W, Hacker MP. Chemical properties and antitumor activity of complexes of platinum containing substituted sulfoxides [PtCl(R'R''SO)(diamine)]NO3. Chirality and leaving-group ability of sulfoxide affecting biological activity Inorganic Chemistry. 29: 397-403. DOI: 10.1021/Ic00328A011 |
0.302 |
|
| 1990 |
Farrell N, Almeida SGd, Yun Q. Complex salts of platinum with ethylenediamine and propanediamine [PtCl(diamine)L][PtCl3L] Inorganica Chimica Acta. 178: 209-211. DOI: 10.1016/S0020-1693(00)86783-3 |
0.358 |
|
| 1990 |
Skov KA, Farrell NP, Chaplin DJ. Platinum complexes with one radiosensitizing ligand International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 17. DOI: 10.1016/0883-2897(90)90034-X |
0.426 |
|
| 1990 |
Qu Y, Farrell N. Effect of diamine linker on the chemistry of bis(platinum) complexes. A comparison of the aqueous solution behavior of 1,4-butanediamine and 2,5-dimethyl-2,5-hexanediamine complexes Journal of Inorganic Biochemistry. 40: 255-264. DOI: 10.1016/0162-0134(90)80059-7 |
0.367 |
|
| 1989 |
Farrell N, Ha TTB, Souchard JP, Wimmer FL, Cros S, Johnson NP. Cytostatic trans-platinum(II) complexes. Journal of Medicinal Chemistry. 32: 2240-2241. PMID 2795596 DOI: 10.1021/Jm00130A002 |
0.344 |
|
| 1989 |
Roberts JD, van Houten B, Qu Y, Farrell NP. Interaction of novel bis(platinum) complexes with DNA Nucleic Acids Research. 17: 9719-9733. PMID 2690006 DOI: 10.1093/Nar/17.23.9719 |
0.461 |
|
| 1989 |
Richmond RC, Farrell NP, Curphey TJ, Mahtani HK. Potentiation of radiation-induced bacterial cell killing by binuclear rhodium(II) complexes and their amines Radiation Research. 120: 416-429. PMID 2687933 DOI: 10.2307/3577793 |
0.315 |
|
| 1989 |
Farrell N, Qu Y. Chemistry of bis(platinum) complexes. Formation of trans derivatives from tetraamine complexes Inorganic Chemistry. 28: 3416-3420. DOI: 10.1021/Ic00317A005 |
0.425 |
|
| 1989 |
Kraker A, Elliot W, VanHouten B, Farrell N, Hoeschele J, Roberts J. Chemistry, cytotoxicity, and DNA-binding of bis-platinum complexes Journal of Inorganic Biochemistry. 36: 160. DOI: 10.1016/0162-0134(89)84048-6 |
0.41 |
|
| 1988 |
Farrell NP, De Almeida SG, Skov KA. Bis(platinum) complexes containing two platinum cis-diammine units. Synthesis and initial DNA-binding studies Journal of the American Chemical Society. 110: 5018-5019. DOI: 10.1021/Ja00223A019 |
0.437 |
|
| 1988 |
Hoeschele JD, Farrell N, Turner WR, Rithner CD. Synthesis and characterization of diastereomeric (substituted iminodiacetato) (1,2- diaminocyclohexane)platinum(II) complexes Inorganic Chemistry. 27: 4106-4113. DOI: 10.1021/Ic00296A007 |
0.313 |
|
| 1987 |
Skov KA, Farrell NP, Adomat H. Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: Radiosensitization and toxicity studies in vitro Radiation Research. 112: 273-282. PMID 3685256 DOI: 10.2307/3577255 |
0.421 |
|
| 1987 |
Skov KA, Farrell NP. Binding mode of 2-amino-5-nitrothiazole (ANT) in platinum complexes, trans-[ptcl2(ANT)2], affects DNA binding, toxicity and radiosensitizing ability International Journal of Radiation Biology. 52: 289-297. PMID 3497126 DOI: 10.1080/09553008714551751 |
0.415 |
|
| 1987 |
Skov KA, Adomat H, Konway DC, Farrell NP. Assessment of DNA binding of platinum-radiosensitizer complexes by inhibition of restriction enzymes Chemico-Biological Interactions. 62: 117-129. PMID 3036382 DOI: 10.1016/0009-2797(87)90084-6 |
0.424 |
|
| 1987 |
Farrell N, Skov KA. Radiosensitizers targeted to DNA using platinum. Synthesis, characterisation, and DNA binding of cis-[PtCl2(NH3)(nitroimidazole)] Journal of the Chemical Society, Chemical Communications. 1043-1044. DOI: 10.1039/C39870001043 |
0.409 |
|
| 1987 |
Farrell N, Vargas MD, Mascarenhas YA, Gambardella MTdP. Rhodium carboxylate complexes of diphenyltriazene and berenil, a substituted triazene and DNA binding ligand. Crystal and molecular structure of tetrakis(.mu.-acetato)bis(diphenyltriazene)dirhodium (II) Inorganic Chemistry. 26: 1426-1429. DOI: 10.1021/Ic00256A020 |
0.397 |
|
| 1986 |
Chan PKL, Skov KA, James BR, Farrell NP. Chromosome-damaging activity of a ruthenium radio-sensitizer, RuCl2(DMSO)2(4-Nitroimidazole)2, in Chinese hamster ovary cells in vitro Chemico-Biological Interactions. 59: 247-254. PMID 3769054 DOI: 10.1016/S0009-2797(86)80070-9 |
0.347 |
|
| 1986 |
Chan PKL, Skov KA, James BR, Farrell NP. A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2 International Journal of Radiation Oncology, Biology, Physics. 12: 1059-1062. PMID 3744927 DOI: 10.1016/0360-3016(86)90225-7 |
0.448 |
|
| 1978 |
Davies AR, Einstein FWB, Farrell NP, James BR, Mcmillan RS. Synthesis, properties, and X-ray structural characterization of the hexakis(dimethyl sulfoxide)ruthenium(II) cation Inorganic Chemistry. 17: 1965-1969. DOI: 10.1021/Ic50185A054 |
0.306 |
|
| 1978 |
Carroll JA, Cobbledick RE, Einstein FWB, Farrell N, Sutton D, Vogel PL. Aryldiazenido, Aryldiazene, and Arylhydrazido Complexes. Reaction of Diazonium Ions with Carbonylhydridotris(triphenylphosphine)iridium(I) and the X-Ray Structure of Iridium Complexes Containing Singly and Doubly Protonated Orthometal Cheminform. 9. DOI: 10.1002/Chin.197801345 |
0.306 |
|
| 1977 |
Farrell N, Sutton D. Aryldiazenido- and aryldiazene complexes: reaction of ethanol with aryldiazenido-complexes of iridium(III) to form orthometallated derivatives Journal of the Chemical Society-Dalton Transactions. 2124-2128. DOI: 10.1039/Dt9770002124 |
0.357 |
|
| 1977 |
Cobbledick RE, Einstein FWB, Farrell N, Gilchrist AB, Sutton D. Aryldiazenato-complexes : synthesis and structure of complexes derived from the oxidative addition of diazonium ions to trans-carbonylchlorobis(triphenylphosphine)iridium(I) Journal of the Chemical Society-Dalton Transactions. 373-379. DOI: 10.1039/Dt9770000373 |
0.385 |
|
| 1977 |
Carroll JA, Cobbledick RE, Einstein FWB, Farrell N, Sutton D, Vogel PL. Aryldiazenido, aryldiazene, and arylhydrazido complexes. Reaction of diazonium ions with carbonylhydridotris(triphenylphosphine)iridium(I) and the x-ray structures of iridium complexes containing singly and doubly protonated orthometalated aryldiazenido ligands Cheminform. 9: 2462-2469. DOI: 10.1021/Ic50176A007 |
0.351 |
|
| 1977 |
Cobbledick RE, Einstein FWB, Farrell N, Gilchrist AB, Sutton D. Aryldiazenato-Complexes- Synthesis And Structure Of Complexes Derived From The Oxidative Addition Of Diazonium Ions To Trans-Chlorocarbonylbis(Triphenylphosphine)Iridium(I) Cheminform. 8. DOI: 10.1002/Chin.197718068 |
0.315 |
|
| 1976 |
Eaborn C, Farrell N, Pidcock A. Cationic palladium and platinum complexes with diolefin ligands Journal of the Chemical Society-Dalton Transactions. 289-292. DOI: 10.1039/Dt9760000289 |
0.684 |
|
| 1976 |
Eaborn C, Farrell N, Murphy JL, Pidcock A. Reactions of methyl fluorosulphate and triethyloxonium tetrafluoroborate with transition-metal complexes Journal of the Chemical Society, Dalton Transactions. 58-67. DOI: 10.1039/Dt9760000058 |
0.669 |
|
| 1976 |
Eaborn C, Farrell N, Pidcock A. Cationic Palladium And Platinum Complexes With Diolefin Ligands Cheminform. 7. DOI: 10.1002/Chin.197615358 |
0.685 |
|
| 1976 |
Eaborn C, Farrell N, Murphy JL, Pidcock A. Reactions Of Methyl Fluorosulfate And Triethyloxonium Tetrafluoroborate With Transition Metal Complexes Cheminform. 7. DOI: 10.1002/Chin.197612289 |
0.647 |
|
| 1974 |
Eaborn C, Farrell N, Pidcock A. Activation Of Platinum Complexes By Methyl Fluorosulphonate, Olefin Isomerization And Alkyne Insertion Cheminform. 5. DOI: 10.1002/Chin.197405186 |
0.66 |
|
| 1973 |
Eaborn C, Farrell N, Pidcock A. Activation of platinum complexes by methyl fluorosulphonate: olefin isomerization and alkyne insertion Journal of the Chemical Society, Chemical Communications. 766-767. DOI: 10.1039/C39730000766 |
0.701 |
|
| Show low-probability matches. |
