| Year |
Citation |
Score |
| 2015 |
Chang WL, Hsu LC, Leu WJ, Chen CS, Guh JH. Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation. Oncotarget. PMID 26447757 DOI: 10.18632/oncotarget.5655 |
0.312 |
|
| 2015 |
Liu TM, Ling Y, Woyach JA, Beckwith K, Yeh YY, Hertlein E, Zhang X, Lehman A, Awan F, Jones JA, Andritsos LA, Maddocks K, MacMurray J, Salunke SB, Chen CS, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 125: 284-95. PMID 25293770 DOI: 10.1182/Blood-2014-06-583518 |
0.316 |
|
| 2013 |
Lee SL, Chou CC, Chuang HC, Hsu EC, Chiu PC, Kulp SK, Byrd JC, Chen CS. Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines. Plos One. 8: e67149. PMID 23840605 DOI: 10.1371/Journal.Pone.0067149 |
0.31 |
|
| 2013 |
Ma Y, McCarty SK, Kapuriya NP, Brendel VJ, Wang C, Zhang X, Jarjoura D, Saji M, Chen CS, Ringel MD. Development of p21 activated kinase-targeted multikinase inhibitors that inhibit thyroid cancer cell migration. The Journal of Clinical Endocrinology and Metabolism. 98: E1314-22. PMID 23709653 DOI: 10.1210/Jc.2012-3937 |
0.327 |
|
| 2013 |
Yang YL, Huang PH, Chiu HC, Kulp SK, Chen CS, Kuo CJ, Chen HD, Chen CS. Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism. Biochemical and Biophysical Research Communications. 435: 107-12. PMID 23624506 DOI: 10.1016/J.Bbrc.2013.04.049 |
0.309 |
|
| 2013 |
Liu T, Ling Y, Phelps MA, Woyach JA, Hertlein EK, Towns WH, MacMurray J, Salunke SB, Chen C, Byrd JC, Johnson AJ. OSU-T315, An Integrin-Linked Kinase (ILK) Inhibitor, Induces Apoptosis By Targeting B Cell Receptor and CD49d Mediated AKT/ERK Activation In Chronic Lymphocytic Leukemia Cells Blood. 122: 2523-2523. DOI: 10.1182/Blood.V122.21.2523.2523 |
0.306 |
|
| 2011 |
Bai LY, Ma Y, Kulp SK, Wang SH, Chiu CF, Frissora F, Mani R, Mo X, Jarjoura D, Byrd JC, Chen CS, Muthusamy N. OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway. British Journal of Haematology. 153: 623-33. PMID 21470196 DOI: 10.1111/J.1365-2141.2010.08443.X |
0.348 |
|
| 2011 |
Ching TT, Chiang WC, Chen CS, Hsu AL. Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity. Aging Cell. 10: 506-19. PMID 21348927 DOI: 10.1111/j.1474-9726.2011.00688.x |
0.631 |
|
| 2011 |
Mani R, Frissora FW, Chen C, Byrd JC, Muthusamy N. OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase Blood. 118: 2499-2499. DOI: 10.1182/Blood.V118.21.2499.2499 |
0.304 |
|
| 2010 |
Oaks JJ, Mukhopadhyay A, Santhanam R, Saddoughi SA, Walker C, Neviani P, Harb JG, Ma Y, Verstovsek S, Marcucci G, Briesewitz R, Bittman R, Chen C, Quintas-Cardama A, Ogretmen B, et al. Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders Blood. 116: 775-775. DOI: 10.1182/Blood.V116.21.775.775 |
0.318 |
|
| 2009 |
Bai L, Ma Y, Kulp SK, Wang S, Chiu C, Frissora F, Mo X, Jarjoura D, Byrd JC, Chen C, Muthusamy N. OSU-DY7, a Novel D-Tyrosinol Derivative, Mediates Cytotoxicity in Chronic Lymphocytic Leukemia and Lymphoblastic Lymphoma through p38 Mitogen-Activated Protein Kinase Pathway. Blood. 114: 3778-3778. DOI: 10.1182/Blood.V114.22.3778.3778 |
0.311 |
|
| 2009 |
Oaks J, Neviani P, Mukhopadhyay A, Santhanam R, Ma Y, Mao C, Marcucci G, Chen C, Cortes J, Caligiuri MA, Hokland P, Huettner C, Koschmieder S, Cancelas J, Briesewitz R, et al. FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor. Blood. 114: 3259-3259. DOI: 10.1182/Blood.V114.22.3259.3259 |
0.315 |
|
| 2008 |
Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Research. 68: 1204-12. PMID 18281497 DOI: 10.1158/0008-5472.Can-07-2621 |
0.333 |
|
| 2007 |
Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, Shinohara M, Kulp SK, Kirschner LS, Saji M, Chen CS, Ringel MD. 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. Molecular Pharmacology. 72: 1124-31. PMID 17673571 DOI: 10.1124/Mol.107.037556 |
0.366 |
|
| 2006 |
Yacoub A, Park MA, Hanna D, Hong Y, Mitchell C, Pandya AP, Harada H, Powis G, Chen CS, Koumenis C, Grant S, Dent P. OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Molecular Pharmacology. 70: 589-603. PMID 16622074 DOI: 10.1124/Mol.106.025007 |
0.335 |
|
| 2006 |
Tong Z, Wu X, Chen CS, Kehrer JP. Cytotoxicity of a non-cyclooxygenase-2 inhibitory derivative of celecoxib in non-small-cell lung cancer A549 cells. Lung Cancer (Amsterdam, Netherlands). 52: 117-24. PMID 16497409 DOI: 10.1016/J.Lungcan.2005.12.003 |
0.366 |
|
| 2006 |
White VL, Zhang S, Lucas D, Chen C, Farag SS. OSU-HDAC42, a Novel Histone Deacetylase Inhibitor, Induces Apoptosis in a Caspase-Dependent Manner and Induces p21WAF1/CIP1 and p16 Expression in Multiple Myeloma Cell Lines. Blood. 108: 5078-5078. DOI: 10.1182/blood.v108.11.5078.5078 |
0.313 |
|
| 2006 |
Zhang S, White VL, Johnson A, Chen C, Farag SS. OSU03012, a Novel Celecoxib Derivative, Induces Apoptosis in Multiple Myeloma Cells Independently of Caspase Activation. Blood. 108: 5075-5075. DOI: 10.1182/blood.v108.11.5075.5075 |
0.31 |
|
| 2005 |
Kucab JE, Lee C, Chen CS, Zhu J, Gilks CB, Cheang M, Huntsman D, Yorida E, Emerman J, Pollak M, Dunn SE. Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours. Breast Cancer Research : Bcr. 7: R796-807. PMID 16168126 DOI: 10.1186/Bcr1294 |
0.365 |
|
| 2005 |
Tong Z, Wu X, Ovcharenko D, Zhu J, Chen CS, Kehrer JP. Neutrophil gelatinase-associated lipocalin as a survival factor. The Biochemical Journal. 391: 441-8. PMID 16060857 DOI: 10.1042/Bj20051020 |
0.411 |
|
| 2005 |
Gardner OS, Shiau CW, Chen CS, Graves LM. Peroxisome proliferator-activated receptor γ-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent Protein kinase II and protein kinase R: Correlation with endoplasmic reticulum stress Journal of Biological Chemistry. 280: 10109-10118. PMID 15649892 DOI: 10.1074/jbc.M410445200 |
0.336 |
|
| 2004 |
Lin HP, Kulp SK, Tseng PH, Yang YT, Yang CC, Chen CS, Chen CS. Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms. Molecular Cancer Therapeutics. 3: 1671-80. PMID 15634661 |
0.337 |
|
| 2004 |
Shaw YJ, Yang YT, Garrison JB, Kyprianou N, Chen CS. Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation. Journal of Medicinal Chemistry. 47: 4453-62. PMID 15317457 DOI: 10.1021/Jm049752K |
0.304 |
|
| 2004 |
Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Research. 64: 4309-18. PMID 15205346 DOI: 10.1158/0008-5472.Can-03-4063 |
0.461 |
|
| 2004 |
Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS. 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer Research. 64: 1444-51. PMID 14973075 DOI: 10.1158/0008-5472.Can-03-2396 |
0.437 |
|
| 2003 |
Yang CC, Lin HP, Chen CS, Yang YT, Tseng PH, Rangnekar VM, Chen CS. Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells. The Journal of Biological Chemistry. 278: 25872-8. PMID 12738789 DOI: 10.1074/Jbc.M301744200 |
0.406 |
|
| 2002 |
Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, Chen CS. Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. Journal of the National Cancer Institute. 94: 1745-57. PMID 12464646 DOI: 10.1093/Jnci/94.23.1745 |
0.578 |
|
| 2002 |
Johnson AJ, Hsu AL, Lin HP, Song X, Chen CS. The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risks. The Biochemical Journal. 366: 831-7. PMID 12076251 DOI: 10.1042/Bj20020279 |
0.661 |
|
| 2002 |
Song X, Lin HP, Johnson AJ, Tseng PH, Yang YT, Kulp SK, Chen CS. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. Journal of the National Cancer Institute. 94: 585-91. PMID 11959891 DOI: 10.1093/Jnci/94.8.585 |
0.516 |
|
| 2001 |
Ching TT, Lin HP, Yang CC, Oliveira M, Lu PJ, Chen CS. Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif. The Journal of Biological Chemistry. 276: 43932-8. PMID 11555646 DOI: 10.1074/jbc.M105159200 |
0.551 |
|
| 2001 |
Ching TT, Hsu AL, Johnson AJ, Chen CS. Phosphoinositide 3-kinase facilitates antigen-stimulated Ca(2+) influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca(2+) entry mechanism. The Journal of Biological Chemistry. 276: 14814-20. PMID 11278575 DOI: 10.1074/jbc.M009851200 |
0.696 |
|
| 2001 |
Wang DS, Hsu AL, Chen CS. A phosphatidylinositol 3,4,5-trisphosphate analogue with low serum protein-binding affinity. Bioorganic & Medicinal Chemistry. 9: 133-9. PMID 11197333 |
0.547 |
|
| 2000 |
Wang DS, Ching TT, St Pyrek J, Chen CS. Biotinylated phosphatidylinositol 3,4,5-trisphosphate as affinity ligand. Analytical Biochemistry. 280: 301-7. PMID 10790314 DOI: 10.1006/Abio.2000.4525 |
0.598 |
|
| 2000 |
Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM, Chen CS. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. The Journal of Biological Chemistry. 275: 11397-403. PMID 10753955 DOI: 10.1074/Jbc.275.15.11397 |
0.698 |
|
| 2000 |
Hsu AL, Ching TT, Sen G, Wang DS, Bondada S, Authi KS, Chen CS. Novel function of phosphoinositide 3-kinase in T cell Ca2+ signaling. A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca2+ entry mechanism. The Journal of Biological Chemistry. 275: 16242-50. PMID 10748064 DOI: 10.1074/Jbc.M002077200 |
0.709 |
|
| 1999 |
Ching TT, Wang DS, Hsu AL, Lu PJ, Chen CS. Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4, 5-trisphosphate. The Journal of Biological Chemistry. 274: 8611-7. PMID 10085097 |
0.672 |
|
| 1998 |
Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Current Biology : Cb. 8: 1069-77. PMID 9768361 DOI: 10.1016/S0960-9822(98)70444-0 |
0.403 |
|
| 1998 |
Lu PJ, Hsu AL, Wang DS, Chen CS. Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca2+ influx. Biochemistry. 37: 9776-83. PMID 9657691 DOI: 10.1021/bi980163o |
0.606 |
|
| 1998 |
Lu PJ, Hsu AL, Wang DS, Yan HY, Yin HL, Chen CS. Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry. 37: 5738-45. PMID 9548960 DOI: 10.1021/bi972551g |
0.608 |
|
| 1998 |
Hsu AL, Lu PJ, Chen CS. Regulation of nuclear calcium uptake by inositol phosphates and external calcium. Biochemical and Biophysical Research Communications. 243: 653-6. PMID 9500990 DOI: 10.1006/bbrc.1998.8161 |
0.597 |
|
| 1998 |
Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. The Journal of Biological Chemistry. 273: 4465-9. PMID 9468499 DOI: 10.1074/Jbc.273.8.4465 |
0.455 |
|
| 1997 |
Lu P, Chen C. Selective Recognition of Phosphatidylinositol 3,4,5-Trisphosphate by a Synthetic Peptide Journal of Biological Chemistry. 272: 466-472. PMID 8995284 DOI: 10.1074/Jbc.272.1.466 |
0.379 |
|
| 1996 |
Rameh LE, Chen CS, Cantley LC. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell. 83: 821-30. PMID 8521499 DOI: 10.1016/0092-8674(95)90195-7 |
0.405 |
|
| 1996 |
Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 270: 29525-31. PMID 7493994 DOI: 10.1074/Jbc.270.49.29525 |
0.409 |
|
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