| Year |
Citation |
Score |
| 2024 |
Eccles MK, Main N, Carlessi R, Armstrong AM, Sabale M, Roberts-Mok B, Tirnitz-Parker JEE, Agostino M, Groth D, Fraser PE, Verdile G. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 38: e23396. PMID 38156414 DOI: 10.1096/fj.202300954RR |
0.314 |
|
| 2022 |
Takamura H, Nakayama Y, Ito H, Katayama T, Fraser PE, Matsuzaki S. SUMO1 Modification of Tau in Progressive Supranuclear Palsy. Molecular Neurobiology. 59: 4419-4435. PMID 35567706 DOI: 10.1007/s12035-022-02734-5 |
0.331 |
|
| 2021 |
Zhang Y, Zhang Y, Aman Y, Ng CT, Chau WH, Zhang Z, Yue M, Bohm C, Jia Y, Li S, Yuan Q, Griffin J, Chiu K, Wong DSM, Wang B, ... ... Fraser PE, et al. Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway. Brain : a Journal of Neurology. PMID 34428276 DOI: 10.1093/brain/awab134 |
0.305 |
|
| 2021 |
Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J. Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia. PMID 34427354 DOI: 10.1002/glia.24077 |
0.395 |
|
| 2021 |
Ruiz-Riquelme A, Mao A, Barghash MM, Lau HHC, Stuart E, Kovacs GG, Nilsson KPR, Fraser PE, Schmitt-Ulms G, Watts JC. Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice. Acta Neuropathologica Communications. 9: 83. PMID 33971978 DOI: 10.1186/s40478-021-01187-6 |
0.361 |
|
| 2021 |
Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathologica Communications. 9: 64. PMID 33832546 DOI: 10.1186/s40478-021-01171-0 |
0.313 |
|
| 2021 |
Vilalta A, Zhou Y, Sevalle J, Griffin JK, Satoh K, Allendorf DH, De S, Puigdellívol M, Bruzas A, Burguillos MA, Dodd RB, Chen F, Zhang Y, Flagmeier P, Needham LM, ... ... Fraser PE, et al. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation. The Journal of Biological Chemistry. 100631. PMID 33823153 DOI: 10.1016/j.jbc.2021.100631 |
0.349 |
|
| 2021 |
Wijesekara N, Gonçalves RA, Ahrens R, Ha K, De Felice FG, Fraser PE. Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice. The Journal of Pathology. PMID 33797777 DOI: 10.1002/path.5674 |
0.32 |
|
| 2020 |
Puzzo D, Argyrousi EK, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, Acquarone E, Fà M, Li Puma DD, Grassi C, D'Adamio L, Kanaan NM, Fraser PE, Arancio O. Tau is not necessary for amyloid-beta-induced synaptic and memory impairments. The Journal of Clinical Investigation. PMID 32544084 DOI: 10.1172/Jci137040 |
0.447 |
|
| 2020 |
Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG. Behavioral Abnormalities in Knockout and Humanized Tau Mice. Frontiers in Endocrinology. 11: 124. PMID 32226410 DOI: 10.3389/Fendo.2020.00124 |
0.404 |
|
| 2019 |
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, et al. α-Synuclein strains target distinct brain regions and cell types. Nature Neuroscience. PMID 31792467 DOI: 10.1038/S41593-019-0541-X |
0.312 |
|
| 2019 |
Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in Cellular Neuroscience. 13: 17. PMID 30804755 DOI: 10.3389/Fncel.2019.00017 |
0.351 |
|
| 2018 |
Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/S41380-018-0258-3 |
0.383 |
|
| 2018 |
Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, Berger I, Schaffitzel C, Fraser PE, Martins RN, Verdile G. Efficient production of a mature and functional gamma secretase protease. Scientific Reports. 8: 12834. PMID 30150752 DOI: 10.1038/S41598-018-30788-W |
0.369 |
|
| 2018 |
Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, ... ... Fraser PE, et al. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions. Cell. 173: 720-734.e15. PMID 29677515 DOI: 10.1016/J.Cell.2018.03.056 |
0.306 |
|
| 2018 |
Kent BA, Heath CJ, Kim CH, Ahrens R, Fraser PE, St George-Hyslop P, Bussey TJ, Saksida LM. Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age. Brain and Behavior. 8: e00896. PMID 29568692 DOI: 10.1002/Brb3.896 |
0.403 |
|
| 2018 |
Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, et al. Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease : Jad. 62: 965-992. PMID 29562546 DOI: 10.3233/Jad-171145 |
0.422 |
|
| 2018 |
Wijesekara N, Gonçalves RA, Ahrens R, De Felice FG, Fraser PE. Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701352. PMID 29401605 DOI: 10.1096/Fj.201701352 |
0.341 |
|
| 2017 |
Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE. SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model. Neurobiology of Disease. 110: 154-165. PMID 29217476 DOI: 10.1016/J.Nbd.2017.11.015 |
0.807 |
|
| 2017 |
Wijesekara N, Gonçalves da Silva RA, De Felice FG, Fraser PE. Impaired peripheral glucose homeostasis and Alzheimer's disease. Neuropharmacology. PMID 29169962 DOI: 10.1016/J.Neuropharm.2017.11.027 |
0.429 |
|
| 2017 |
Laws SM, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser PE, Porter T, Newsholme P, Wijesekara N, Burnham S, Doré V, Li QX, Maruff P, Masters CL, Rainey-Smith S, et al. Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports. 7: 9766. PMID 28852028 DOI: 10.1016/J.Jalz.2017.06.2000 |
0.357 |
|
| 2017 |
Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G. Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease. Plos One. 12: e0182844. PMID 28832675 DOI: 10.1371/Journal.Pone.0182844 |
0.438 |
|
| 2017 |
Wijesekara N, Ahrens R, Sabale M, Wu L, Ha K, Verdile G, Fraser PE. Amyloid-β and islet amyloid pathologies link Alzheimer disease and type 2 diabetes in a transgenic model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28808140 DOI: 10.1096/Fj.201700431R |
0.463 |
|
| 2017 |
Puzzo D, Piacentini R, Fa' M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O. LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent. Elife. 6. PMID 28696204 DOI: 10.7554/Elife.26991 |
0.433 |
|
| 2017 |
Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G. The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins. Journal of Alzheimer's Disease : Jad. PMID 28269785 DOI: 10.3233/Jad-161192 |
0.405 |
|
| 2017 |
Puzzo D, Piacentini R, Fá M, Gulisano W, Puma DDL, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O. Author response: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent Elife. DOI: 10.7554/Elife.26991.025 |
0.355 |
|
| 2016 |
Jakobsen JE, Johansen MG, Schmidt M, Liu Y, Li R, Callesen H, Melnikova M, Habekost M, Matrone C, Bouter Y, Bayer TA, Nielsen AL, Duthie M, Fraser PE, Holm IE, et al. Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs. Journal of Alzheimer's Disease : Jad. 53: 1617-1630. PMID 27540966 DOI: 10.3233/Jad-160408 |
0.459 |
|
| 2016 |
Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB. Erratum. Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045-3055. Diabetes. 65: 818. PMID 26908907 DOI: 10.2337/Db16-Er03 |
0.332 |
|
| 2016 |
Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, ... ... Fraser PE, et al. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Scientific Reports. 6: 19393. PMID 26786552 DOI: 10.1038/Srep19393 |
0.431 |
|
| 2015 |
Verdile G, Keane KN, Cruzat VF, Medic S, Sabale M, Rowles J, Wijesekara N, Martins RN, Fraser PE, Newsholme P. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease. Mediators of Inflammation. 2015: 105828. PMID 26693205 DOI: 10.1155/2015/105828 |
0.34 |
|
| 2015 |
Barr RK, Verdile G, Wijaya LK, Morici M, Taddei K, Gupta VB, Pedrini S, Jin L, Nicolazzo JA, Knock E, Fraser PE, Martins RN. Validation and Characterisation of a Novel Peptide that Binds Monomeric and Aggregated Beta-amyloid and Inhibits the Formation of Neurotoxic Oligomers. The Journal of Biological Chemistry. PMID 26538562 DOI: 10.1074/Jbc.M115.679993 |
0.791 |
|
| 2015 |
Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, ... ... Fraser PE, et al. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron. PMID 26526393 DOI: 10.1016/J.Neuron.2015.10.030 |
0.337 |
|
| 2015 |
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, ... ... Fraser P, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020 |
0.391 |
|
| 2015 |
Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE. ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing. The Journal of Biological Chemistry. 290: 24152-65. PMID 26260791 DOI: 10.1074/Jbc.M115.655076 |
0.496 |
|
| 2015 |
Wijesekara N, Ahrens R, Wu L, Ha K, Liu Y, Wheeler MB, Fraser PE. Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes. Diabetes, Obesity & Metabolism. PMID 26095311 DOI: 10.1111/Dom.12529 |
0.385 |
|
| 2015 |
Drisaldi B, Colnaghi L, Fioriti L, Rao N, Myers C, Snyder AM, Metzger DJ, Tarasoff J, Konstantinov E, Fraser PE, Manley JL, Kandel ER. SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports. 11: 1694-702. PMID 26074071 DOI: 10.1016/J.Celrep.2015.04.061 |
0.361 |
|
| 2015 |
Matsuzaki S, Lee L, Knock E, Srikumar T, Sakurai M, Hazrati LN, Katayama T, Staniszewski A, Raught B, Arancio O, Fraser PE. SUMO1 Affects Synaptic Function, Spine Density and Memory. Scientific Reports. 5: 10730. PMID 26022678 DOI: 10.1038/Srep10730 |
0.757 |
|
| 2015 |
Xi Z, van Blitterswijk M, Zhang M, McGoldrick P, McLean JR, Yunusova Y, Knock E, Moreno D, Sato C, McKeever PM, Schneider R, Keith J, Petrescu N, Fraser P, Tartaglia MC, et al. Jump from Pre-mutation to Pathologic Expansion in C9orf72. American Journal of Human Genetics. 96: 962-70. PMID 26004200 DOI: 10.1016/J.Ajhg.2015.04.016 |
0.739 |
|
| 2015 |
Potter KJ, Werner I, Denroche HC, Montane J, Plesner A, Chen Y, Lei D, Soukhatcheva G, Warnock GL, Oberholzer J, Fraser PE, Verchere CB. Amyloid formation in human islets is enhanced by heparin and inhibited by heparinase. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15: 1519-30. PMID 25833002 DOI: 10.1111/Ajt.13134 |
0.391 |
|
| 2015 |
Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways. Molecular and Cellular Neurosciences. 66: 3-11. PMID 25748120 DOI: 10.1016/J.Mcn.2015.02.016 |
0.44 |
|
| 2015 |
Barucker C, Sommer A, Beckmann G, Eravci M, Harmeier A, Schipke CG, Brockschnieder D, Dyrks T, Althoff V, Fraser PE, Hazrati LN, George-Hyslop PS, Breitner JC, Peters O, Multhaup G. Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors. Journal of Alzheimer's Disease : Jad. 44: 613-24. PMID 25318543 DOI: 10.3233/Jad-141902 |
0.452 |
|
| 2015 |
Allemang-Grand R, Scholz J, Ellegood J, Cahill LS, Laliberté C, Fraser PE, Josselyn SA, Sled JG, Lerch JP. Altered brain development in an early-onset murine model of Alzheimer's disease. Neurobiology of Aging. 36: 638-47. PMID 25311279 DOI: 10.1016/J.Neurobiolaging.2014.08.032 |
0.408 |
|
| 2014 |
Li Y, Bohm C, Dodd R, Chen F, Qamar S, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Structural biology of presenilin 1 complexes. Molecular Neurodegeneration. 9: 59. PMID 25523933 DOI: 10.1186/1750-1326-9-59 |
0.316 |
|
| 2014 |
Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH. Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions. The Journal of Biological Chemistry. 289: 31224-40. PMID 25231978 DOI: 10.1074/Jbc.M114.559237 |
0.331 |
|
| 2014 |
Fraser PE. Prions and prion-like proteins. The Journal of Biological Chemistry. 289: 19839-40. PMID 24860092 DOI: 10.1074/Jbc.R114.583492 |
0.381 |
|
| 2014 |
Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE, Pang KS. 1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7091-101. PMID 24849345 DOI: 10.1523/Jneurosci.2711-13.2014 |
0.375 |
|
| 2014 |
Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model. The Journal of Comparative Neurology. 522: 2319-35. PMID 24415002 DOI: 10.1002/Cne.23536 |
0.423 |
|
| 2014 |
Kanemoto S, Griffin J, Markham-Coultes K, Aubert I, Tandon A, George-Hyslop PS, Fraser PE. Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice. Neuroscience. 261: 52-9. PMID 24361736 DOI: 10.1016/J.Neuroscience.2013.12.021 |
0.417 |
|
| 2014 |
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, ... ... Fraser PE, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/J.Str.2013.09.018 |
0.3 |
|
| 2013 |
Lee L, Sakurai M, Matsuzaki S, Arancio O, Fraser P. SUMO and Alzheimer's disease. Neuromolecular Medicine. 15: 720-36. PMID 23979993 DOI: 10.1007/S12017-013-8257-7 |
0.457 |
|
| 2013 |
Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. The Journal of Biological Chemistry. 288: 15352-66. PMID 23589300 DOI: 10.1074/Jbc.M112.441840 |
0.445 |
|
| 2013 |
Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, ... ... Fraser P, et al. Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts. Molecular Neurodegeneration. 8: 10. PMID 23414597 DOI: 10.1186/1750-1326-8-10 |
0.419 |
|
| 2013 |
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Fraser P, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry. 18: 889-97. PMID 22850627 DOI: 10.1038/Mp.2012.106 |
0.406 |
|
| 2012 |
McLean D, Cooke MJ, Wang Y, Green D, Fraser PE, George-Hyslop PS, Shoichet MS. Anti-amyloid-β-mediated positron emission tomography imaging in Alzheimer's disease mouse brains. Plos One. 7: e51958. PMID 23284831 DOI: 10.1371/Journal.Pone.0051958 |
0.345 |
|
| 2012 |
Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease. Molecular Neurodegeneration. 7: 58. PMID 23173713 DOI: 10.1186/1750-1326-7-58 |
0.457 |
|
| 2012 |
Lauritzen I, Pardossi-Piquard R, Bauer C, Brigham E, Abraham JD, Ranaldi S, Fraser P, St-George-Hyslop P, Le Thuc O, Espin V, Chami L, Dunys J, Checler F. The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16243-55a. PMID 23152608 DOI: 10.1523/Jneurosci.2775-12.2012 |
0.418 |
|
| 2012 |
Lu SH, Jeon AH, Schmitt-Ulms G, Qamar S, Dodd R, McDonald B, Li Y, Meadows W, Cox K, Bohm C, Chen F, Fraser P, George-Hyslop PS. Vigilin interacts with signal peptide peptidase. Proteome Science. 10: 33. PMID 22607704 DOI: 10.1186/1477-5956-10-33 |
0.357 |
|
| 2012 |
McLean D, Cooke MJ, Wang Y, Fraser P, St George-Hyslop P, Shoichet MS. Targeting the amyloid-β antibody in the brain tissue of a mouse model of Alzheimer's disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. 159: 302-8. PMID 22245684 DOI: 10.1016/J.Jconrel.2011.12.036 |
0.373 |
|
| 2012 |
St George-Hyslop P, Fraser PE. Assembly of the presenilin γ-/ε-secretase complex. Journal of Neurochemistry. 120: 84-8. PMID 22122073 DOI: 10.1111/J.1471-4159.2011.07505.X |
0.329 |
|
| 2012 |
Matsuzaki S, Fraser P, Yamada K, George-Hyslop NS, Katayama T, Tohyama M, Raught B. SUMOylation connections to plaque and tangle pathology Alzheimers & Dementia. 8: 628. DOI: 10.1016/J.Jalz.2012.05.1674 |
0.38 |
|
| 2012 |
Satoh K, Abe-Dohmae S, Yokoyama S, George-Hyslop PS, Fraser P. ATP-binding cassette transporter A7 (ABCA7) effects on amyloid processing and relevance to Alzheimer's disease Alzheimers & Dementia. 8: 473. DOI: 10.1016/J.Jalz.2012.05.1272 |
0.345 |
|
| 2011 |
Sanjo N, Qina T, Hori T, Fraser P, Mizusawa H. An Effect of I143T PSEN1 Mutation on The Generation of Amyloid B in Culture Cells Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2442 |
0.317 |
|
| 2010 |
Sanjo N, Katayama T, Hasegawa H, Jin H, Duthie M, Mount HT, Mizusawa H, St George-Hyslop P, Fraser PE. Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase. Neuroscience Letters. 483: 53-6. PMID 20674680 DOI: 10.1016/J.Neulet.2010.07.061 |
0.372 |
|
| 2010 |
Giehm L, Degan Fd, Fraser P, Klysner S, Otzen D. An Aβ concatemer with altered aggregation propensities Biochimica Et Biophysica Acta. 1804: 2025-2035. PMID 20619363 DOI: 10.1016/J.Bbapap.2010.06.023 |
0.442 |
|
| 2010 |
Exley C, House E, Patel T, Wu L, Fraser PE. Human pro-islet amyloid polypeptide (ProIAPP(1-48)) forms amyloid fibrils and amyloid spherulites in vitro. Journal of Inorganic Biochemistry. 104: 1125-9. PMID 20579740 DOI: 10.1016/J.Jinorgbio.2010.05.012 |
0.431 |
|
| 2010 |
Kim SH, Fraser PE, Westaway D, St George-Hyslop PH, Ehrlich ME, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3870-5. PMID 20237257 DOI: 10.1523/Jneurosci.4717-09.2010 |
0.452 |
|
| 2010 |
Zraika S, Hull RL, Verchere CB, Clark A, Potter KJ, Fraser PE, Raleigh DP, Kahn SE. Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia. 53: 1046-56. PMID 20182863 DOI: 10.1007/S00125-010-1671-6 |
0.442 |
|
| 2010 |
Potter KJ, Abedini A, Marek P, Klimek AM, Butterworth S, Driscoll M, Baker R, Nilsson MR, Warnock GL, Oberholzer J, Bertera S, Trucco M, Korbutt GS, Fraser PE, Raleigh DP, et al. Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts. Proceedings of the National Academy of Sciences of the United States of America. 107: 4305-10. PMID 20160085 DOI: 10.1073/Pnas.0909024107 |
0.347 |
|
| 2010 |
Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D. Wild-type Shadoo proteins convert to amyloid-like forms under native conditions. Journal of Neurochemistry. 113: 92-104. PMID 20067571 DOI: 10.1111/J.1471-4159.2010.06575.X |
0.382 |
|
| 2009 |
Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration. 4: 51. PMID 20017949 DOI: 10.1186/1750-1326-4-51 |
0.446 |
|
| 2009 |
Ryan SD, Whitehead SN, Swayne LA, Moffat TC, Hou W, Ethier M, Bourgeois AJ, Rashidian J, Blanchard AP, Fraser PE, Park DS, Figeys D, Bennett SA. Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proceedings of the National Academy of Sciences of the United States of America. 106: 20936-41. PMID 19926863 DOI: 10.1073/Pnas.0905654106 |
0.44 |
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| 2009 |
Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration. 4: 40. PMID 19845940 DOI: 10.1186/1750-1326-4-40 |
0.408 |
|
| 2009 |
Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. TMP21 transmembrane domain regulates gamma-secretase cleavage. The Journal of Biological Chemistry. 284: 28634-41. PMID 19710022 DOI: 10.1074/Jbc.M109.059345 |
0.403 |
|
| 2009 |
Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. The Journal of Biological Chemistry. 284: 16298-307. PMID 19369254 DOI: 10.1074/Jbc.M109.000067 |
0.377 |
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| 2009 |
Potter KJ, Scrocchi LA, Warnock GL, Ao Z, Younker MA, Rosenberg L, Lipsett M, Verchere CB, Fraser PE. Amyloid inhibitors enhance survival of cultured human islets. Biochimica Et Biophysica Acta. 1790: 566-74. PMID 19264107 DOI: 10.1016/J.Bbagen.2009.02.013 |
0.478 |
|
| 2009 |
Gandy S, Cirrito J, Steele J, Kim SH, Thinakaran G, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM. S4-04-06: Dimebon®: A Clinically Promising Drug for Alzheimer's Disease, Regulates Amyloid-Beta Metabolism in Cultured Cells, In Isolated Nerve Terminals, and In the Interstitial Fluid of the Living Rodent Brain Alzheimer's & Dementia. 5: e5-e5. DOI: 10.1016/J.Jalz.2009.07.133 |
0.367 |
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| 2008 |
Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB. Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes. 57: 3045-55. PMID 18694973 DOI: 10.2337/Db08-0485 |
0.445 |
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| 2008 |
Dolcini V, Dunys J, Sevalle J, Chen F, Guillot-Sestier MV, St George-Hyslop P, Fraser PE, Checler F. TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin. Biochemical and Biophysical Research Communications. 371: 69-74. PMID 18405662 DOI: 10.1016/J.Bbrc.2008.03.151 |
0.439 |
|
| 2008 |
Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A. Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. Bmc Neuroscience. 9: 17. PMID 18234110 DOI: 10.1186/1471-2202-9-17 |
0.47 |
|
| 2008 |
Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G. The in vivo brain interactome of the amyloid precursor protein. Molecular & Cellular Proteomics : McP. 7: 15-34. PMID 17934213 DOI: 10.1074/Mcp.M700077-Mcp200 |
0.425 |
|
| 2008 |
Potter K, Abedini A, Baker R, Butterworth S, Driscoll M, Marek P, Korbutt G, Fraser P, Raleigh D, Verchere C. Lack of amyloidogenicity and altered prohormone processing of porcine islet amyloid polypeptide may promote function and survival of pig islet xenografts. Canadian Journal of Diabetes. 32: 365. DOI: 10.1016/S1499-2671(08)24259-0 |
0.355 |
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| 2008 |
Wakutani Y, Pardossi-Piquard R, Gu Y, Murakami T, Yang S, Bohm C, Chen F, Yip E, Rogaeva E, Fraser P, Westaway D, Hyslop PS. P3-376: Gene expression profiling in a transgenic mouse model of Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1946 |
0.345 |
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| 2007 |
Pardossi-Piquard R, Chen F, Silva-Gagliardi NF, Szego M, McInnes R, McGlade CJ, St George-Hyslop P, Fraser PE. Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. Biochemistry. 46: 13704-10. PMID 17988153 DOI: 10.1021/Bi701347W |
0.406 |
|
| 2007 |
Van Vickle GD, Esh CL, Kalback WM, Patton RL, Luehrs DC, Kokjohn TA, Fifield FG, Fraser PE, Westaway D, McLaurin J, Lopez J, Brune D, Newel AJ, Poston M, Beach TG, et al. TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry. 46: 10317-27. PMID 17705508 DOI: 10.1021/Bi700951U |
0.487 |
|
| 2007 |
Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, et al. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. The Embo Journal. 26: 4038-50. PMID 17703189 DOI: 10.1038/Sj.Emboj.7601830 |
0.306 |
|
| 2007 |
Serpell LC, Benson M, Liepnieks JJ, Fraser PE. Structural analyses of fibrinogen amyloid fibrils. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 14: 199-203. PMID 17701467 DOI: 10.1080/13506120701461111 |
0.432 |
|
| 2007 |
Dorval V, Fraser PE. SUMO on the road to neurodegeneration. Biochimica Et Biophysica Acta. 1773: 694-706. PMID 17475350 DOI: 10.1016/J.Bbamcr.2007.03.017 |
0.39 |
|
| 2007 |
Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE. Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. The Biochemical Journal. 404: 309-16. PMID 17346237 DOI: 10.1042/Bj20061451 |
0.5 |
|
| 2007 |
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, ... ... Fraser PE, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nature Genetics. 39: 168-77. PMID 17220890 DOI: 10.1038/Ng1943 |
0.482 |
|
| 2006 |
McLaurin J, Kierstead ME, Brown ME, Hawkes CA, Lambermon MH, Phinney AL, Darabie AA, Cousins JE, French JE, Lan MF, Chen F, Wong SS, Mount HT, Fraser PE, Westaway D, et al. Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Medicine. 12: 801-8. PMID 16767098 DOI: 10.1038/Nm1423 |
0.497 |
|
| 2006 |
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, ... ... Fraser P, et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 440: 1208-12. PMID 16641999 DOI: 10.1038/Nature04667 |
0.371 |
|
| 2006 |
Dorval V, Fraser PE. Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. The Journal of Biological Chemistry. 281: 9919-24. PMID 16464864 DOI: 10.1074/Jbc.M510127200 |
0.397 |
|
| 2006 |
Uchihara T, Sanjo N, Nakamura A, Han K, Song SY, St George-Hyslop P, Fraser PE. Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum. Neurobiology of Aging. 27: 88-97. PMID 16298244 DOI: 10.1016/J.Neurobiolaging.2004.12.011 |
0.334 |
|
| 2006 |
Lee S, Paitel E, Drisaldi B, Petit A, Schmidt S, Mathews PM, Chen F, Fraser PE, George-Hyslop PS, Meijer L, Westaway D. P4-282: Effects of indirubin, a GSK3/CDK5 inhibitor, on the Aβ and tau pathways of Alzheimer’s Disease Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2021 |
0.376 |
|
| 2006 |
Chen F, Schmitt-Ulms G, Hasegawa H, Fraser P, George-Hyslop PS. P3-419: Identification of presenilin-associated proteins and potential regulators of the gamma-secretase complex Alzheimer's & Dementia. 2: S499-S499. DOI: 10.1016/J.Jalz.2006.05.1690 |
0.32 |
|
| 2006 |
Dorval V, Fraser PE. P3-311: Sumo modification of natively unfolded proteins tau and alpha-synuclein Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1581 |
0.305 |
|
| 2005 |
Petit A, Kawarai T, Paitel E, Sanjo N, Maj M, Scheid M, Chen F, Gu Y, Hasegawa H, Salehi-Rad S, Wang L, Rogaeva E, Fraser P, Robinson B, St George-Hyslop P, et al. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. The Journal of Biological Chemistry. 280: 34025-32. PMID 16079129 DOI: 10.1074/Jbc.M505143200 |
0.312 |
|
| 2005 |
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, ... ... Fraser PE, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proceedings of the National Academy of Sciences of the United States of America. 102: 8972-7. PMID 15951428 DOI: 10.1073/Pnas.0500940102 |
0.462 |
|
| 2005 |
Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. The Journal of Biological Chemistry. 280: 19070-7. PMID 15764596 DOI: 10.1074/jbc.M501130200 |
0.306 |
|
| 2004 |
Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142 |
0.348 |
|
| 2004 |
Cui JG, Fraser PE, St George-Hyslop P, Westaway D, Lukiw WJ. Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression. Neuroreport. 15: 2025-8. PMID 15486475 DOI: 10.1097/00001756-200409150-00006 |
0.38 |
|
| 2004 |
Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, et al. Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. The Journal of Biological Chemistry. 279: 55443-54. PMID 15459186 DOI: 10.1074/Jbc.M404794200 |
0.34 |
|
| 2004 |
Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. The Journal of Biological Chemistry. 279: 46455-63. PMID 15322109 DOI: 10.1074/Jbc.M406289200 |
0.365 |
|
| 2004 |
Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Disease and Associated Disorders. 18: 44-6. PMID 15195463 DOI: 10.1097/00002093-200401000-00009 |
0.333 |
|
| 2004 |
Gu Y, Sanjo N, Chen F, Hasegawa H, Petit A, Ruan X, Li W, Shier C, Kawarai T, Schmitt-Ulms G, Westaway D, St George-Hyslop P, Fraser PE. The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities. The Journal of Biological Chemistry. 279: 31329-36. PMID 15123598 DOI: 10.1074/Jbc.M401548200 |
0.349 |
|
| 2004 |
Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development. 125: 149-51. PMID 15037022 DOI: 10.1016/J.Mad.2003.12.002 |
0.387 |
|
| 2004 |
Verdile G, Groth D, Mathews PM, St George-Hyslop P, Fraser PE, Ramabhadran TV, Kwok JB, Schofield PR, Carter T, Gandy S, Martins RN. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Molecular Psychiatry. 9: 594-602. PMID 14993906 DOI: 10.1038/Sj.Mp.4001458 |
0.467 |
|
| 2003 |
Tandon A, Yu H, Wang L, Rogaeva E, Sato C, Chishti MA, Kawarai T, Hasegawa H, Chen F, Davies P, Fraser PE, Westaway D, St George-Hyslop PH. Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. Journal of Neurochemistry. 86: 572-81. PMID 12859671 DOI: 10.1046/J.1471-4159.2003.01865.X |
0.39 |
|
| 2003 |
Scrocchi LA, Ha K, Chen Y, Wu L, Wang F, Fraser PE. Identification of minimal peptide sequences in the (8-20) domain of human islet amyloid polypeptide involved in fibrillogenesis. Journal of Structural Biology. 141: 218-27. PMID 12648568 DOI: 10.1016/S1047-8477(02)00630-5 |
0.385 |
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| 2003 |
Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, et al. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. The Journal of Biological Chemistry. 278: 19974-9. PMID 12646573 DOI: 10.1074/Jbc.M210049200 |
0.379 |
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| 2003 |
Gorman PM, Yip CM, Fraser PE, Chakrabartty A. Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH. Journal of Molecular Biology. 325: 743-57. PMID 12507477 DOI: 10.1016/S0022-2836(02)01279-2 |
0.41 |
|
| 2003 |
Qin K, Coomaraswamy J, Mastrangelo P, Yang Y, Lugowski S, Petromilli C, Prusiner SB, Fraser PE, Goldberg JM, Chakrabartty A, Westaway D. The PrP-like protein Doppel binds copper. The Journal of Biological Chemistry. 278: 8888-96. PMID 12482851 DOI: 10.1074/Jbc.M210875200 |
0.305 |
|
| 2003 |
Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, Li W, Ruan X, Luthra A, Mount HT, Tandon A, Fraser PE, St George-Hyslop P. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. The Journal of Biological Chemistry. 278: 7374-80. PMID 12471034 DOI: 10.1074/Jbc.M209499200 |
0.377 |
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| 2003 |
Mastrangelo P, Serpell L, Dafforn T, Lesk A, Fraser P, Westaway D. A cluster of familial Creutzfeldt-Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry? Febs Letters. 532: 21-6. PMID 12459456 DOI: 10.1016/S0014-5793(02)03614-1 |
0.331 |
|
| 2002 |
Arawaka S, Hasegawa H, Tandon A, Janus C, Chen F, Yu G, Kikuchi K, Koyama S, Kato T, Fraser PE, St George-Hyslop P. The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein. Journal of Neurochemistry. 83: 1065-71. PMID 12437577 DOI: 10.1046/J.1471-4159.2002.01207.X |
0.448 |
|
| 2002 |
Tandon A, Fraser P. The presenilins. Genome Biology. 3: reviews3014. PMID 12429067 |
0.372 |
|
| 2002 |
Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, ... Fraser P, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proceedings of the National Academy of Sciences of the United States of America. 99: 14452-7. PMID 12388777 DOI: 10.1073/Pnas.222413999 |
0.426 |
|
| 2002 |
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, et al. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nature Medicine. 8: 1263-9. PMID 12379850 DOI: 10.1038/Nm790 |
0.436 |
|
| 2002 |
Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch. The Journal of Biological Chemistry. 277: 36521-6. PMID 12119298 DOI: 10.1074/Jbc.M205093200 |
0.447 |
|
| 2002 |
Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neuroscience Research. 43: 39-56. PMID 12074840 DOI: 10.1016/S0168-0102(02)00015-9 |
0.464 |
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| 2002 |
Scrocchi LA, Chen Y, Waschuk S, Wang F, Cheung S, Darabie AA, McLaurin J, Fraser PE. Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis. Journal of Molecular Biology. 318: 697-706. PMID 12054816 DOI: 10.1016/S0022-2836(02)00164-X |
0.391 |
|
| 2002 |
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, ... Fraser PE, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/Jbc.M110871200 |
0.427 |
|
| 2002 |
Petit A, St George-Hyslop P, Fraser P, Checler F. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells. Biochemical and Biophysical Research Communications. 290: 1408-10. PMID 11820778 DOI: 10.1006/Bbrc.2002.6349 |
0.408 |
|
| 2002 |
Jo E, Fuller N, Rand RP, St George-Hyslop P, Fraser PE. Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. Journal of Molecular Biology. 315: 799-807. PMID 11812148 DOI: 10.1006/Jmbi.2001.5269 |
0.305 |
|
| 2002 |
Yu WH, Go L, Guinn BA, Fraser PE, Westaway D, McLaurin J. Phenotypic and functional changes in glial cells as a function of age. Neurobiology of Aging. 23: 105-15. PMID 11755025 DOI: 10.1016/S0197-4580(01)00258-5 |
0.309 |
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| 2002 |
Westaway D, Janus C, Johnson H, Chishti MA, McLaurin J, Mathews P, Jiang Y, Schmidt SD, Horne P, French J, Nixon RA, Mercken M, Fraser PE, Bergeron C, Carlson GA, et al. Aβ-immunization reduces learning impairment and amyloid plaque burden in an animal model of Alzheimer's disease European Neuropsychopharmacology. 12: 98. DOI: 10.1016/S0924-977X(02)80030-X |
0.407 |
|
| 2001 |
Fraser P. Amyloids and other abnormal assembly processes, FASEB Summer Conference, Copper Mountain, Colorado, June 11-16, 2000. Amyloid. 8: 285-290. PMID 11791623 DOI: 10.3109/13506120108993827 |
0.455 |
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| 2001 |
Yang DS, Serpell LC, Yip CM, McLaurin J, Chrishti MA, Horne P, Boudreau L, Kisilevsky R, Westaway D, Fraser PE. Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 10-9. PMID 11676284 |
0.409 |
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| 2001 |
Zou WQ, Yang DS, Fraser PE, Cashman NR, Chakrabartty A. All or none fibrillogenesis of a prion peptide. European Journal of Biochemistry / Febs. 268: 4885-91. PMID 11559357 DOI: 10.1046/J.1432-1327.2001.02415.X |
0.434 |
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| 2001 |
Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, ... ... Fraser PE, et al. Nicastrin binds to membrane-tethered Notch. Nature Cell Biology. 3: 751-4. PMID 11483961 DOI: 10.1038/35087069 |
0.423 |
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| 2001 |
Fraser PE, Yu G, Lévesque L, Nishimura M, Yang DS, Mount HT, Westaway D, St George-Hyslop PH. Presenilin function: connections to Alzheimer's disease and signal transduction. Biochemical Society Symposium. 89-100. PMID 11447843 DOI: 10.1042/Bst028A016 |
0.469 |
|
| 2001 |
Waschuk SA, Elton EA, Darabie AA, Fraser PE, McLaurin JA. Cellular membrane composition defines A beta-lipid interactions. The Journal of Biological Chemistry. 276: 33561-8. PMID 11438533 DOI: 10.1074/Jbc.M103598200 |
0.376 |
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| 2001 |
Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, et al. Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiology of Aging. 22: 367-76. PMID 11378241 DOI: 10.1016/S0197-4580(01)00216-0 |
0.433 |
|
| 2001 |
Jaikaran ET, Higham CE, Serpell LC, Zurdo J, Gross M, Clark A, Fraser PE. Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis. Journal of Molecular Biology. 308: 515-25. PMID 11327784 DOI: 10.1006/Jmbi.2001.4593 |
0.429 |
|
| 2001 |
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, ... ... Fraser PE, et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. The Journal of Biological Chemistry. 276: 21562-70. PMID 11279122 DOI: 10.1074/Jbc.M100710200 |
0.476 |
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| 2001 |
Yu WH, Fraser PE. S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2240-6. PMID 11264299 DOI: 10.1523/Jneurosci.21-07-02240.2001 |
0.42 |
|
| 2001 |
Yu WH, Lukiw WJ, Bergeron C, Niznik HB, Fraser PE. Metallothionein III is reduced in Alzheimer's disease. Brain Research. 894: 37-45. PMID 11245813 DOI: 10.1016/S0006-8993(00)03196-6 |
0.381 |
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| 2001 |
Fraser PE, Darabie AA, McLaurin JA. Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development. The Journal of Biological Chemistry. 276: 6412-9. PMID 11106653 DOI: 10.1074/Jbc.M008128200 |
0.442 |
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| 2001 |
Sato N, Imaizumi K, Manabe T, Taniguchi M, Hitomi J, Katayama T, Yoneda T, Morihara T, Yasuda Y, Takagi T, Kudo T, Tsuda T, Itoyama Y, Makifuchi T, Fraser PE, et al. Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2. The Journal of Biological Chemistry. 276: 2108-14. PMID 11031265 DOI: 10.1074/Jbc.M006886200 |
0.468 |
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| 2000 |
St George-Hyslop PH, McLaurin J, Fraser PE. Neuropathological, biochemical and genetic alterations in AD. Drug News & Perspectives. 13: 281-8. PMID 12937642 |
0.303 |
|
| 2000 |
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, et al. Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta Neurologica Scandinavica. Supplementum. 176: 6-11. PMID 11261807 DOI: 10.1034/J.1600-0404.2000.00301.X |
0.305 |
|
| 2000 |
Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. An empirical model of gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 233-40. PMID 11193156 DOI: 10.1111/J.1749-6632.2000.Tb06928.X |
0.383 |
|
| 2000 |
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408: 979-82. PMID 11140685 DOI: 10.1038/35050110 |
0.411 |
|
| 2000 |
Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, ... Fraser PE, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202 DOI: 10.1007/Bf03401825 |
0.383 |
|
| 2000 |
Yang DS, McLaurin J, Qin K, Westaway D, Fraser PE. Examining the zinc binding site of the amyloid-beta peptide. European Journal of Biochemistry / Febs. 267: 6692-8. PMID 11054124 DOI: 10.1046/J.1432-1327.2000.01767.X |
0.454 |
|
| 2000 |
Serpell LC, Blake CC, Fraser PE. Molecular structure of a fibrillar Alzheimer's A beta fragment. Biochemistry. 39: 13269-75. PMID 11052680 DOI: 10.1021/Bi000637V |
0.47 |
|
| 2000 |
McLaurin J, Fraser PE. Effect of amino-acid substitutions on Alzheimer's amyloid-beta peptide-glycosaminoglycan interactions. European Journal of Biochemistry / Febs. 267: 6353-61. PMID 11029577 DOI: 10.1046/J.1432-1327.2000.01725.X |
0.444 |
|
| 2000 |
Inouye H, Nguyen JT, Fraser PE, Shinchuk LM, Packard AB, Kirschner DA. Histidine residues underlie Congo red binding to A beta analogs. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 179-88. PMID 11019858 DOI: 10.3109/13506120009146832 |
0.338 |
|
| 2000 |
Lévesque L, Mizzen CA, McLachlan DR, Fraser PE. Ligand specific effects on aluminum incorporation and toxicity in neurons and astrocytes. Brain Research. 877: 191-202. PMID 10986332 DOI: 10.1016/S0006-8993(00)02637-8 |
0.32 |
|
| 2000 |
Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, ... ... Fraser PE, et al. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. The Journal of Biological Chemistry. 275: 36794-802. PMID 10962005 DOI: 10.1074/Jbc.M006986200 |
0.453 |
|
| 2000 |
Huang TH, Yang DS, Fraser PE, Chakrabartty A. Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in vitro model of preamyloid. The Journal of Biological Chemistry. 275: 36436-40. PMID 10961999 DOI: 10.1074/Jbc.M005698200 |
0.472 |
|
| 2000 |
McLaurin J, Yang D, Yip CM, Fraser PE. Review: modulating factors in amyloid-beta fibril formation. Journal of Structural Biology. 130: 259-70. PMID 10940230 DOI: 10.1006/Jsbi.2000.4289 |
0.454 |
|
| 2000 |
Janus C, D'Amelio S, Amitay O, Chishti MA, Strome R, Fraser P, Carlson GA, Roder JC, St George-Hyslop P, Westaway D. Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiology of Aging. 21: 541-9. PMID 10924767 DOI: 10.1016/S0197-4580(00)00107-X |
0.326 |
|
| 2000 |
Jo E, McLaurin J, Yip CM, St George-Hyslop P, Fraser PE. alpha-Synuclein membrane interactions and lipid specificity. The Journal of Biological Chemistry. 275: 34328-34. PMID 10915790 DOI: 10.1074/Jbc.M004345200 |
0.31 |
|
| 2000 |
Serpell LC, Sunde M, Benson MD, Tennent GA, Pepys MB, Fraser PE. The protofilament substructure of amyloid fibrils. Journal of Molecular Biology. 300: 1033-9. PMID 10903851 DOI: 10.1006/Jmbi.2000.3908 |
0.47 |
|
| 2000 |
Fraser PE, Yang DS, Yu G, Lévesque L, Nishimura M, Arawaka S, Serpell LC, Rogaeva E, St George-Hyslop P. Presenilin structure, function and role in Alzheimer disease. Biochimica Et Biophysica Acta. 1502: 1-15. PMID 10899427 DOI: 10.1016/S0925-4439(00)00028-4 |
0.469 |
|
| 2000 |
Smith SK, Anderson HA, Yu G, Robertson AG, Allen SJ, Tyler SJ, Naylor RL, Mason G, Wilcock GW, Roche PA, Fraser PE, Dawbarn D. Identification of syntaxin 1A as a novel binding protein for presenilin-1. Brain Research. Molecular Brain Research. 78: 100-7. PMID 10891589 DOI: 10.1016/S0169-328X(00)00079-6 |
0.348 |
|
| 2000 |
Qin K, Yang DS, Yang Y, Chishti MA, Meng LJ, Kretzschmar HA, Yip CM, Fraser PE, Westaway D. Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation. The Journal of Biological Chemistry. 275: 19121-31. PMID 10858456 DOI: 10.1074/Jbc.275.25.19121 |
0.305 |
|
| 2000 |
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, et al. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. The Journal of Biological Chemistry. 275: 27348-53. PMID 10856299 DOI: 10.1074/Jbc.M002982200 |
0.342 |
|
| 2000 |
Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. The Journal of Biological Chemistry. 275: 26277-84. PMID 10816583 DOI: 10.1074/Jbc.M002812200 |
0.434 |
|
| 2000 |
Verdile G, Martins RN, Duthie M, Holmes E, St George-Hyslop PH, Fraser PE. Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1. The Journal of Biological Chemistry. 275: 20794-8. PMID 10801777 DOI: 10.1074/Jbc.C000208200 |
0.449 |
|
| 2000 |
McLaurin J, Golomb R, Jurewicz A, Antel JP, Fraser PE. Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity. The Journal of Biological Chemistry. 275: 18495-502. PMID 10764800 DOI: 10.1074/jbc.M906994199 |
0.346 |
|
| 2000 |
Higham CE, Jaikaran ET, Fraser PE, Gross M, Clark A. Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils. Febs Letters. 470: 55-60. PMID 10722845 DOI: 10.1016/S0014-5793(00)01287-4 |
0.383 |
|
| 2000 |
Huang TH, Yang DS, Plaskos NP, Go S, Yip CM, Fraser PE, Chakrabartty A. Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide. Journal of Molecular Biology. 297: 73-87. PMID 10704308 DOI: 10.1006/Jmbi.2000.3559 |
0.421 |
|
| 2000 |
Fraser PE. S100β interactions with tau in alzheimer's disease and the analysis of chemical properties required Neurobiology of Aging. 21: 221. DOI: 10.1016/S0197-4580(00)83324-2 |
0.368 |
|
| 2000 |
Yu G, Chen F, Nishimura M, Holmes E, Fraser PE. Structural maturation of presenilin protein complexes is inhibited by mutation of the conserved intramembrane asparate residues Neurobiology of Aging. 21: 150. DOI: 10.1016/S0197-4580(00)82476-8 |
0.312 |
|
| 1999 |
McLaurin J, Franklin T, Kuhns WJ, Fraser PE. A sulfated proteoglycan aggregation factor mediates amyloid-beta peptide fibril formation and neurotoxicity. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 6: 233-43. PMID 10611943 DOI: 10.3109/13506129909007334 |
0.453 |
|
| 1999 |
McLaurin J, Franklin T, Zhang X, Deng J, Fraser PE. Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth. European Journal of Biochemistry / Febs. 266: 1101-10. PMID 10583407 DOI: 10.1046/J.1432-1327.1999.00957.X |
0.447 |
|
| 1999 |
Yang DS, Yip CM, Huang TH, Chakrabartty A, Fraser PE. Manipulating the amyloid-beta aggregation pathway with chemical chaperones. The Journal of Biological Chemistry. 274: 32970-4. PMID 10551864 DOI: 10.1074/Jbc.274.46.32970 |
0.454 |
|
| 1999 |
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. The Journal of Cell Biology. 147: 277-94. PMID 10525535 DOI: 10.1083/Jcb.147.2.277 |
0.46 |
|
| 1999 |
Serpell LC, Fraser PE, Sunde M. X-ray fiber diffraction of amyloid fibrils. Methods in Enzymology. 309: 526-36. PMID 10507046 DOI: 10.1016/S0076-6879(99)09036-9 |
0.318 |
|
| 1999 |
Miake H, Tsuchiya K, Nakamura A, Ikeda K, Levesque L, Fraser PE, St-George Hyslop PH, Mizusawa H, Uchihara T. Glial expression of presenilin epitopes in human brain with cerebral infarction and in astrocytoma. Acta Neuropathologica. 98: 337-40. PMID 10502036 DOI: 10.1007/S004010051090 |
0.352 |
|
| 1999 |
Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981 |
0.392 |
|
| 1999 |
Romero I, Jørgensen P, Bolwig G, Fraser PE, Rogaeva E, Mann D, Havsager AM, Jørgensen AL. A presenilin-1 Thr116Asn substitution in a family with early-onset Alzheimer's disease. Neuroreport. 10: 2255-60. PMID 10439444 DOI: 10.1097/00001756-199908020-00006 |
0.416 |
|
| 1999 |
Kisilevsky R, Lemieux L, Boudreau L, Yang DS, Fraser P. New clothes for amyloid enhancing factor (AEF): silk as AEF. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 6: 98-106. PMID 10439115 DOI: 10.3109/13506129909007309 |
0.424 |
|
| 1999 |
Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, ... ... Fraser PE, et al. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. Journal of Neurochemistry. 72: 999-1008. PMID 10037471 DOI: 10.1046/J.1471-4159.1999.0720999.X |
0.404 |
|
| 1998 |
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, Xu D, Liang Y, Duthie M, St George-Hyslop PH, Fraser PE. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. The Journal of Biological Chemistry. 273: 16470-5. PMID 9632714 DOI: 10.1074/Jbc.273.26.16470 |
0.4 |
|
| 1998 |
Tamaoka A, Fraser PE, Ishii K, Sahara N, Ozawa K, Ikeda M, Saunders AM, Komatsuzaki Y, Sherrington R, Levesque G, Yu G, Rogaeva E, Shoji S, Nee LE, Pollen DA, et al. Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease. Brain Research. Molecular Brain Research. 56: 178-85. PMID 9602117 DOI: 10.1016/S0169-328X(98)00044-8 |
0.439 |
|
| 1998 |
McLaurin J, Franklin T, Chakrabartty A, Fraser PE. Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest. Journal of Molecular Biology. 278: 183-94. PMID 9571042 DOI: 10.1006/Jmbi.1998.1677 |
0.461 |
|
| 1998 |
McLaurin J, Franklin T, Fraser PE, Chakrabartty A. Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides. The Journal of Biological Chemistry. 273: 4506-15. PMID 9468505 DOI: 10.1074/Jbc.273.8.4506 |
0.451 |
|
| 1997 |
Brown DR, Qin K, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A, Westaway D, Kretzschmar H. The cellular prion protein binds copper in vivo. Nature. 390: 684-7. PMID 9414160 DOI: 10.1038/37783 |
0.313 |
|
| 1997 |
Kisilevsky R, Fraser PE. A beta amyloidogenesis: unique, or variation on a systemic theme? Critical Reviews in Biochemistry and Molecular Biology. 32: 361-404. PMID 9383610 DOI: 10.3109/10409239709082674 |
0.472 |
|
| 1997 |
Sunde M, Serpell LC, Bartlam M, Fraser PE, Pepys MB, Blake CC. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. Journal of Molecular Biology. 273: 729-39. PMID 9356260 DOI: 10.1006/Jmbi.1997.1348 |
0.447 |
|
| 1997 |
Huang TH, Fraser PE, Chakrabartty A. Fibrillogenesis of Alzheimer Abeta peptides studied by fluorescence energy transfer. Journal of Molecular Biology. 269: 214-24. PMID 9191066 DOI: 10.1006/Jmbi.1997.1050 |
0.408 |
|
| 1997 |
Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/Nbdi.1997.0129 |
0.43 |
|
| 1997 |
Kwok JB, Taddei K, Hallupp M, Fisher C, Brooks WS, Broe GA, Hardy J, Fulham MJ, Nicholson GA, Stell R, St George Hyslop PH, Fraser PE, Kakulas B, Clarnette R, Relkin N, et al. Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport. 8: 1537-42. PMID 9172170 DOI: 10.1097/00001756-199704140-00043 |
0.333 |
|
| 1997 |
Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St George-Hyslop P. Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics. 40: 415-24. PMID 9073509 DOI: 10.1006/Geno.1996.4523 |
0.311 |
|
| 1997 |
Booth DR, Sunde M, Bellotti V, Robinson CV, Hutchinson WL, Fraser PE, Hawkins PN, Dobson CM, Radford SE, Blake CC, Pepys MB. Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature. 385: 787-93. PMID 9039909 DOI: 10.1038/385787A0 |
0.456 |
|
| 1997 |
De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. The Journal of Biological Chemistry. 272: 3590-8. PMID 9013610 DOI: 10.1074/Jbc.272.6.3590 |
0.413 |
|
| 1997 |
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, ... ... Fraser P, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nature Medicine. 3: 67-72. PMID 8986743 DOI: 10.1038/Nm0197-67 |
0.432 |
|
| 1997 |
Peter HG, Fraser PE, Rommens JM. Genetic sequences and proteins related to alzheimer's disease, and uses therefor Biofutur. 1997: 43. DOI: 10.1016/S0294-3506(97)89236-8 |
0.407 |
|
| 1996 |
Sr George-Hyslop PH, Levesque G, Levesque L, Rommens J, Westaway D, Fraser PE. Two homologous genes causing early-onset familial Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 559-64. PMID 9246482 DOI: 10.1101/Sqb.1996.061.01.056 |
0.333 |
|
| 1996 |
Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483 DOI: 10.1007/Bf03401652 |
0.457 |
|
| 1996 |
Pepys MB, Tennent GA, Booth DR, Bellotti V, Lovat LB, Tan SY, Persey MR, Hutchinson WL, Booth SE, Madhoo S, Soutar AK, Hawkins PN, Van Zyl-Smit R, Campistol JM, Fraser PE, et al. Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy. Ciba Foundation Symposium. 199: 73-81; discussion 81. PMID 8915605 DOI: 10.1002/9780470514924.CH6 |
0.38 |
|
| 1996 |
Kisilevsky R, Fraser P. Proteoglycans and amyloid fibrillogenesis. Ciba Foundation Symposium. 199: 58-67; discussion 68. PMID 8915604 DOI: 10.1002/9780470514924.CH5 |
0.413 |
|
| 1996 |
Uchihara T, el Hachimi HK, Duyckaerts C, Foncin JF, Fraser PE, Levesque L, St George-Hyslop PH, Hauw JJ. Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study. Acta Neuropathologica. 92: 325-30. PMID 8891063 DOI: 10.1007/S004010050526 |
0.352 |
|
| 1996 |
Booth DR, Bellotti V, Sunde M, Robinson CV, Fraser PE, Radford SE, Blake CCF, Hawkins PN, Pepys MB. Molecular Mechanisms of Amyloid Fibril Formation: The Lysozyme Model Clinical Science. 90: 1P-1P. DOI: 10.1042/Cs090001Pa |
0.379 |
|
| 1996 |
George-Hyslop PHS, Rogaev EI, Sherrington R, Rogaev EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Fraser PE, Rommens JM. 601 Two homologous genes associated with early onset familial Alzheimer's disease Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80603-8 |
0.338 |
|
| 1996 |
George-Hyslop PS, Rogaev EI, Sherrington R, Rogaeva EA, Rogaeva G, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Fraser PE, Rommens JM. Two homologous genes associated with early onset familial Alzheimer's disease Biological Psychiatry. 39: 562. DOI: 10.1016/0006-3223(96)84160-6 |
0.377 |
|
| 1995 |
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, Mar L, Sorbi S, Nacmias B, Piacentini S, Amaducci L, ... ... Fraser PE, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene Nature. 376: 775-778. PMID 7651536 DOI: 10.1038/376775A0 |
0.363 |
|
| 1995 |
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, ... ... Fraser PE, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375: 754-60. PMID 7596406 DOI: 10.1038/375754A0 |
0.394 |
|
| 1995 |
Kisilevsky R, Lemieux LJ, Fraser PE, Kong X, Hultin PG, Szarek WA. Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease. Nature Medicine. 1: 143-8. PMID 7585011 DOI: 10.1038/Nm0295-143 |
0.484 |
|
| 1995 |
Serpell LC, Sunde M, Fraser PE, Luther PK, Morris EP, Sangren O, Lundgren E, Blake CC. Examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs. Journal of Molecular Biology. 254: 113-8. PMID 7490736 DOI: 10.1006/Jmbi.1995.0604 |
0.357 |
|
| 1994 |
Snow AD, Sekiguchi R, Nochlin D, Fraser P, Kimata K, Mizutani A, Arai M, Schreier WA, Morgan DG. An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron. 12: 219-34. PMID 8292358 DOI: 10.1016/0896-6273(94)90165-1 |
0.405 |
|
| 1994 |
Fraser PE, Lévesque L, McLachlan DR. Alzheimer A beta amyloid forms an inhibitory neuronal substrate. Journal of Neurochemistry. 62: 1227-30. PMID 8113806 DOI: 10.1046/J.1471-4159.1994.62031227.X |
0.306 |
|
| 1994 |
Fraser PE, McLachlan DR, Surewicz WK, Mizzen CA, Snow AD, Nguyen JT, Kirschner DA. Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues. Journal of Molecular Biology. 244: 64-73. PMID 7966323 DOI: 10.1006/Jmbi.1994.1704 |
0.425 |
|
| 1993 |
Fraser PE, Nguyen JT, McLachlan DR, Abraham CR, Kirschner DA. Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro. Journal of Neurochemistry. 61: 298-305. PMID 8515277 DOI: 10.1111/J.1471-4159.1993.Tb03568.X |
0.451 |
|
| 1993 |
Come JH, Fraser PE, Lansbury PT. A kinetic model for amyloid formation in the prion diseases: importance of seeding. Proceedings of the National Academy of Sciences of the United States of America. 90: 5959-63. PMID 8327467 DOI: 10.1073/Pnas.90.13.5959 |
0.479 |
|
| 1993 |
Fraser PE, Lévesque L, McLachlan DR. Biochemistry of Alzheimer's disease amyloid plaques. Clinical Biochemistry. 26: 339-49. PMID 8299204 DOI: 10.1016/0009-9120(93)90110-R |
0.501 |
|
| 1992 |
Caputo CB, Fraser PE, Sobel IE, Kirschner DA. Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of beta-amyloid protein precursor. Archives of Biochemistry and Biophysics. 292: 199-205. PMID 1727636 DOI: 10.1016/0003-9861(92)90068-8 |
0.44 |
|
| 1992 |
Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry. 31: 10716-23. PMID 1420187 DOI: 10.1021/Bi00159A011 |
0.305 |
|
| 1992 |
Fraser PE, Nguyen JT, Chin DT, Kirschner DA. Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions. Journal of Neurochemistry. 59: 1531-40. PMID 1402902 DOI: 10.1111/J.1471-4159.1992.Tb08470.X |
0.425 |
|
| 1991 |
Fraser PE, Duffy LK, O'Malley MB, Nguyen J, Inouye H, Kirschner DA. Morphology and antibody recognition of synthetic beta-amyloid peptides. Journal of Neuroscience Research. 28: 474-85. PMID 1908024 DOI: 10.1002/Jnr.490280404 |
0.4 |
|
| 1991 |
Fraser PE, Nguyen JT, Surewicz WK, Kirschner DA. pH-dependent structural transitions of Alzheimer amyloid peptides. Biophysical Journal. 60: 1190-201. PMID 1760507 DOI: 10.1016/S0006-3495(91)82154-3 |
0.332 |
|
| 1990 |
Halverson K, Fraser PE, Kirschner DA, Lansbury PT. Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic beta-protein fragments. Biochemistry. 29: 2639-44. PMID 2346740 DOI: 10.1021/Bi00463A003 |
0.387 |
|
| 1985 |
Fraser PE, Deber CM. Structure and function of the proline-rich region of myelin basic protein. Biochemistry. 24: 4593-8. PMID 2415158 DOI: 10.1021/Bi00338A017 |
0.304 |
|
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