| Year |
Citation |
Score |
| 2020 |
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG. The evolution and mechanism of GPCR proton sensing. The Journal of Biological Chemistry. 296: 100167. PMID 33478938 DOI: 10.1074/jbc.RA120.016352 |
0.332 |
|
| 2020 |
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG. The evolution and mechanism of GPCR proton sensing. The Journal of Biological Chemistry. PMID 33298521 DOI: 10.1074/jbc.RA120.016352 |
0.331 |
|
| 2020 |
Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. The Biochemical Journal. PMID 32729927 DOI: 10.1042/Bcj20200311 |
0.418 |
|
| 2020 |
Kapolka NJ, Taghon GJ, Rowe JB, Morgan WM, Enten JF, Lambert NA, Isom DG. DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery. Proceedings of the National Academy of Sciences of the United States of America. PMID 32434907 DOI: 10.1073/Pnas.2000430117 |
0.335 |
|
| 2020 |
Rowe JB, Taghon GJ, Kapolka NJ, Morgan WM, Isom DG. CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology. The Journal of Biological Chemistry. PMID 32358068 DOI: 10.1074/Jbc.Ra120.013066 |
0.312 |
|
| 2020 |
Rowe J, Kapolka N, Taghon G, Morgan W, Isom D. Mechanistic Insights into pH‐sensing GPCRs The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06154 |
0.3 |
|
| 2017 |
Isom DG, Page SC, Collins LB, Kapolka NJ, Taghon GJ, Dohlman HG. Coordinated Regulation of Intracellular pH by Two Glucose Sensing Pathways in Yeast. The Journal of Biological Chemistry. PMID 29284676 DOI: 10.1074/Jbc.Ra117.000422 |
0.716 |
|
| 2017 |
Shellhammer JP, Morin-Kensicki E, Matson JP, Yin G, Isom DG, Campbell SL, Mohney RP, Dohlman HG. Amino acid metabolites that regulate G protein signaling during osmotic stress. Plos Genetics. 13: e1006829. PMID 28558063 DOI: 10.1371/Journal.Pgen.1006829 |
0.69 |
|
| 2016 |
Isom DG, Sridharan V, Dohlman HG. Regulation of Ras Paralog Thermostability by Networks of Buried Ionizable Groups. Biochemistry. 55: 534-42. PMID 26701741 DOI: 10.1021/Acs.Biochem.5B00901 |
0.677 |
|
| 2015 |
Isom DG, Dohlman HG. Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 112: 5702-7. PMID 25902551 DOI: 10.1073/Pnas.1417888112 |
0.622 |
|
| 2013 |
Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL. Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. The Journal of Biological Chemistry. 288: 36856-62. PMID 24247240 DOI: 10.1074/Jbc.C113.525691 |
0.668 |
|
| 2013 |
Isom DG, Sridharan V, Baker R, Clement ST, Smalley DM, Dohlman HG. Protons as second messenger regulators of G protein signaling. Molecular Cell. 51: 531-8. PMID 23954348 DOI: 10.1016/J.Molcel.2013.07.012 |
0.767 |
|
| 2011 |
Isom DG, Castañeda CA, Cannon BR, García-Moreno B. Large shifts in pKa values of lysine residues buried inside a protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 5260-5. PMID 21389271 DOI: 10.1073/Pnas.1010750108 |
0.756 |
|
| 2011 |
Isom DG, Marguet PR, Oas TG, Hellinga HW. A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. Proteins. 79: 1034-47. PMID 21387407 DOI: 10.1002/Prot.22932 |
0.456 |
|
| 2011 |
Khangulov V, Castaneda CA, Chimenti MS, Harms MJ, Isom DG, Schlessman JL, Garcia-Moreno BE. Strong Coulomb Interactions Between Internal and Surface Charges in Proteins Biophysical Journal. 100: 218a. DOI: 10.1016/J.Bpj.2010.12.1404 |
0.664 |
|
| 2010 |
Isom DG, Castañeda CA, Cannon BR, Velu PD, GarcÃa-Moreno E B. Charges in the hydrophobic interior of proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 16096-100. PMID 20798341 DOI: 10.1073/Pnas.1004213107 |
0.754 |
|
| 2010 |
Isom DG, Vardy E, Oas TG, Hellinga HW. Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. Proceedings of the National Academy of Sciences of the United States of America. 107: 4908-13. PMID 20194783 DOI: 10.1073/Pnas.0910421107 |
0.438 |
|
| 2009 |
Harms MJ, Castañeda CA, Schlessman JL, Sue GR, Isom DG, Cannon BR, García-Moreno E B. The pK(a) values of acidic and basic residues buried at the same internal location in a protein are governed by different factors. Journal of Molecular Biology. 389: 34-47. PMID 19324049 DOI: 10.1016/J.Jmb.2009.03.039 |
0.753 |
|
| 2008 |
Isom DG, Cannon BR, Castañeda CA, Robinson A, García-Moreno B. High tolerance for ionizable residues in the hydrophobic interior of proteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 17784-8. PMID 19004768 DOI: 10.1073/Pnas.0805113105 |
0.757 |
|
| 2007 |
Mitra L, Hata K, Kono R, Maeno A, Isom D, Rouget JB, Winter R, Akasaka K, García-Moreno B, Royer CA. V(i)-value analysis: a pressure-based method for mapping the folding transition state ensemble of proteins. Journal of the American Chemical Society. 129: 14108-9. PMID 17960902 DOI: 10.1021/Ja073576Y |
0.689 |
|
| 2006 |
Brun L, Isom DG, Velu P, GarcÃa-Moreno B, Royer CA. Hydration of the folding transition state ensemble of a protein. Biochemistry. 45: 3473-80. PMID 16533028 DOI: 10.1021/Bi052638Z |
0.452 |
|
| 2003 |
Gong H, Isom DG, Srinivasan R, Rose GD. Local secondary structure content predicts folding rates for simple, two-state proteins. Journal of Molecular Biology. 327: 1149-54. PMID 12662937 DOI: 10.1016/S0022-2836(03)00211-0 |
0.388 |
|
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