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Lu Q. Le, Ph.D. - Publications

Affiliations: 
2002 University of California, Los Angeles, Los Angeles, CA 
Area:
Immunology, Genetics, Cell Biology
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mo J, Anastasaki C, Chen Z, Shipman T, Papke JB, Yin KY, Gutmann DH, Le LQ. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. The Journal of Clinical Investigation. PMID 33108355 DOI: 10.1172/JCI139807  0.311
2020 Brosseau JP, Liao CP, Le LQ. Translating current basic research into future therapies for neurofibromatosis type 1. British Journal of Cancer. PMID 32439933 DOI: 10.1038/S41416-020-0903-X  0.391
2020 Chen Z, Mo J, Brosseau J, Shipman T, Wang Y, Liao C, Cooper JM, Allaway RJ, Gosline SJC, Guinney J, Carroll TJ, Le LQ. Abstract B23: A novel model of neurofibroma that deciphers its developmental origin and susceptibility to modification by the Hippo pathway Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B23  0.395
2019 Le LQ, Cooper JM, Patel AJ, Chen Z, Liao CP, Chen K, Wang Y, Mo J. Overcoming BET inhibitor resistance in malignant peripheral nerve sheath tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30796033 DOI: 10.1158/1078-0432.Ccr-18-2437  0.308
2018 Brosseau JP, Liao CP, Wang Y, Ramani V, Vandergriff T, Lee M, Patel A, Ariizumi K, Le LQ. NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation. Nature Communications. 9: 5014. PMID 30479396 DOI: 10.1038/S41467-018-07452-Y  0.354
2018 Chen Z, Mo J, Brosseau JP, Shipman T, Wang Y, Liao CP, Cooper JM, Allaway RJ, Gosline SJC, Guinney J, Carroll TJ, Le LQ. Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway. Cancer Discovery. PMID 30348677 DOI: 10.1158/2159-8290.Cd-18-0151  0.39
2018 Blakeley JO, Wolkenstein P, Widemann BC, Lee J, Le LQ, Jackson R, Stathis M, Verma SK. Creating a comprehensive research strategy for cutaneous neurofibromas. Neurology. 91: S1-S4. PMID 29987129 DOI: 10.1212/Wnl.0000000000005789  0.304
2018 Allaway RJ, Gosline SJC, La Rosa S, Knight P, Bakker A, Guinney J, Le LQ. Cutaneous neurofibromas in the genomics era: current understanding and open questions. British Journal of Cancer. PMID 29695767 DOI: 10.1038/S41416-018-0073-2  0.353
2018 Fisher MJ, Belzberg AJ, de Blank P, De Raedt T, Elefteriou F, Ferner RE, Giovannini M, Harris GJ, Kalamarides M, Karajannis MA, Kim A, Lázaro C, Le LQ, Li W, Listernick R, et al. 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. American Journal of Medical Genetics. Part A. 176: 1258-1269. PMID 29681099 DOI: 10.1002/Ajmg.A.38675  0.371
2018 Cooper JM, Patel AJ, Chen Z, Liao C, Chen K, Wang Y, Le LQ. Abstract 5797: BET inhibitor synthetic lethality in malignant peripheral nerve sheath tumors Cancer Research. 78: 5797-5797. DOI: 10.1158/1538-7445.Am2018-5797  0.354
2018 Chen Z, Le L. 762 Stem cell origin and spatio-temporal loss of heterozygosity give rise to different types of NF1-associated neurofibroma Journal of Investigative Dermatology. 138: S129. DOI: 10.1016/J.Jid.2018.03.772  0.326
2017 Liao CP, Booker RC, Morrison SJ, Le LQ. Identification of hair shaft progenitors that create a niche for hair pigmentation. Genes & Development. PMID 28465357 DOI: 10.1101/Gad.298703.117  0.301
2016 Liao CP, Pradhan S, Chen Z, Patel AJ, Booker RC, Le LQ. The role of nerve microenvironment for neurofibroma development. Oncotarget. PMID 27517146 DOI: 10.18632/Oncotarget.11133  0.364
2014 Chen Z, Liu C, Patel AJ, Liao CP, Wang Y, Le LQ. Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma. Cancer Cell. 26: 695-706. PMID 25446898 DOI: 10.1016/J.Ccell.2014.09.009  0.4
2014 Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Cell Reports. 6: 81-92. PMID 24373973 DOI: 10.1016/J.Celrep.2013.12.001  0.363
2014 Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Research. 74: 586-97. PMID 24285727 DOI: 10.1158/0008-5472.Can-13-1934  0.371
2014 Patel AJ, Liao C, Chen Z, Liu C, Wang Y, Le LQ. Abstract 3117: BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction Cancer Research. 74: 3117-3117. DOI: 10.1158/1538-7445.Am2014-3117  0.359
2013 Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, et al. CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell. 152: 1077-90. PMID 23434321 DOI: 10.1016/J.Cell.2013.01.053  0.415
2011 Le LQ, Liu C, Shipman T, Chen Z, Suter U, Parada LF. Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer Research. 71: 4686-95. PMID 21551250 DOI: 10.1158/0008-5472.Can-10-4577  0.401
2009 Le LQ, Shipman T, Burns DK, Parada LF. Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell. 4: 453-63. PMID 19427294 DOI: 10.1016/J.Stem.2009.03.017  0.404
2007 Le LQ, Parada LF. Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene. 26: 4609-16. PMID 17297459 DOI: 10.1038/Sj.Onc.1210261  0.401
2005 Witte ON, Kabarowski JH, Xu Y, Le LQ, Zhu K. Retraction. Science (New York, N.Y.). 307: 206. PMID 15653487 DOI: 10.1126/science.307.5707.206b  0.31
2002 Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 1: 381-91. PMID 12086852 DOI: 10.1016/S1535-6108(02)00058-2  0.607
2001 Kabarowski JH, Zhu K, Le LQ, Witte ON, Xu Y. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science (New York, N.Y.). 293: 702-5. PMID 11474113 DOI: 10.1126/Science.1061781  0.492
2001 Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, Miller JF, Witte ON. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 14: 561-71. PMID 11371358 DOI: 10.1016/S1074-7613(01)00145-5  0.508
2000 Kabarowski JH, Feramisco JD, Le LQ, Gu JL, Luoh SW, Simon MI, Witte ON. Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 97: 12109-14. PMID 11050239 DOI: 10.1073/Pnas.97.22.12109  0.49
1998 Weng Z, Fluckiger AC, Nisitani S, Wahl MI, Le LQ, Hunter CA, Fernal AA, Le Beau MM, Witte ON. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proceedings of the National Academy of Sciences of the United States of America. 95: 12334-9. PMID 9770487 DOI: 10.1073/Pnas.95.21.12334  0.501
1998 Lieberman JR, Le LQ, Wu L, Finerman GA, Berk A, Witte ON, Stevenson S. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 16: 330-9. PMID 9671928 DOI: 10.1002/Jor.1100160309  0.45
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