Joshua Akey, PhD - Publications

University of Washington, Seattle, Seattle, WA 

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 McCoy RC, Wakefield J, Akey JM. Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression. Cell. 168: 916-927.e12. PMID 28235201 DOI: 10.1016/j.cell.2017.01.038  0.48
2016 Gittelman RM, Schraiber JG, Vernot B, Mikacenic C, Wurfel MM, Akey JM. Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments. Current Biology : Cb. PMID 27839976 DOI: 10.1016/j.cub.2016.10.041  0.64
2016 Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, ... ... Akey J, et al. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nature Communications. 7: 12522. PMID 27725671 DOI: 10.1038/ncomms12522  0.72
2016 Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, ... ... Akey JM, et al. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. PMID 27487209 DOI: 10.1038/nature19075  0.64
2016 Vernot B, Tucci S, Kelso J, Schraiber JG, Wolf AB, Gittelman RM, Dannemann M, Grote S, McCoy RC, Norton H, Scheinfeldt LB, Merriwether DA, Koki G, Friedlaender JS, Wakefield J, ... ... Akey JM, et al. Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals. Science (New York, N.Y.). PMID 26989198 DOI: 10.1126/science.aad9416  0.64
2016 Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, ... ... Akey JM, et al. The phenotypic legacy of admixture between modern humans and Neandertals. Science (New York, N.Y.). 351: 737-41. PMID 26912863 DOI: 10.1126/science.aad2149  0.72
2016 McCoy RC, Akey JM. Patterns of deleterious variation between human populations reveal an unbalanced load. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787891 DOI: 10.1073/pnas.1524016113  0.72
2015 Schraiber JG, Akey JM. Methods and models for unravelling human evolutionary history. Nature Reviews. Genetics. PMID 26553329 DOI: 10.1038/nrg4005  0.72
2015 Vattathil S, Akey JM. Small Amounts of Archaic Admixture Provide Big Insights into Human History. Cell. 163: 281-4. PMID 26451479 DOI: 10.1016/j.cell.2015.09.042  0.72
2015 Shendure J, Akey JM. The origins, determinants, and consequences of human mutations. Science (New York, N.Y.). 349: 1478-83. PMID 26404824 DOI: 10.1126/science.aaa9119  0.72
2015 Gittelman RM, Hun E, Ay F, Madeoy J, Pennacchio L, Noble WS, Hawkins DR, Akey JM. Comprehensive identification and analysis of human accelerated regulatory DNA. Genome Research. PMID 26104583 DOI: 10.1101/gr.192591.115  0.72
2015 Vernot B, Akey JM. Complex history of admixture between modern humans and Neandertals. American Journal of Human Genetics. 96: 448-53. PMID 25683119 DOI: 10.1016/j.ajhg.2015.01.006  0.72
2015 Emery LS, Magnaye KM, Bigham AW, Akey JM, Bamshad MJ. Estimates of continental ancestry vary widely among individuals with the same mtDNA haplogroup. American Journal of Human Genetics. 96: 183-93. PMID 25620206 DOI: 10.1016/j.ajhg.2014.12.015  0.72
2014 Fu W, Gittelman RM, Bamshad MJ, Akey JM. Characteristics of neutral and deleterious protein-coding variation among individuals and populations. American Journal of Human Genetics. 95: 421-36. PMID 25279984 DOI: 10.1016/j.ajhg.2014.09.006  0.72
2014 Andrie JM, Wakefield J, Akey JM. Heritable variation of mRNA decay rates in yeast. Genome Research. 24: 2000-10. PMID 25258386 DOI: 10.1101/gr.175802.114  0.72
2014 Vernot B, Akey JM. Human evolution: genomic gifts from archaic hominins. Current Biology : Cb. 24: R845-8. PMID 25247359 DOI: 10.1016/j.cub.2014.07.079  0.72
2014 Rogers KJ, Fu W, Akey JM, Monnat RJ. Global and disease-associated genetic variation in the human Fanconi anemia gene family. Human Molecular Genetics. 23: 6815-25. PMID 25104853 DOI: 10.1093/hmg/ddu400  0.72
2014 Connelly CF, Wakefield J, Akey JM. Evolution and genetic architecture of chromatin accessibility and function in yeast. Plos Genetics. 10: e1004427. PMID 24992477 DOI: 10.1371/journal.pgen.1004427  0.72
2014 Vernot B, Akey JM. Resurrecting surviving Neandertal lineages from modern human genomes. Science (New York, N.Y.). 343: 1017-21. PMID 24476670 DOI: 10.1126/science.1245938  0.72
2013 Stergachis AB, Haugen E, Shafer A, Fu W, Vernot B, Reynolds A, Raubitschek A, Ziegler S, LeProust EM, Akey JM, Stamatoyannopoulos JA. Exonic transcription factor binding directs codon choice and affects protein evolution. Science (New York, N.Y.). 342: 1367-72. PMID 24337295 DOI: 10.1126/science.1243490  0.72
2013 Fu W, O'Connor TD, Akey JM. Genetic architecture of quantitative traits and complex diseases. Current Opinion in Genetics & Development. 23: 678-83. PMID 24287334 DOI: 10.1016/j.gde.2013.10.008  0.72
2013 Stergachis AB, Neph S, Reynolds A, Humbert R, Miller B, Paige SL, Vernot B, Cheng JB, Thurman RE, Sandstrom R, Haugen E, Heimfeld S, Murry CE, Akey JM, Stamatoyannopoulos JA. Developmental fate and cellular maturity encoded in human regulatory DNA landscapes. Cell. 154: 888-903. PMID 23953118 DOI: 10.1016/j.cell.2013.07.020  0.72
2013 O'Connor TD, Kiezun A, Bamshad M, Rich SS, Smith JD, Turner E, Leal SM, Akey JM. Fine-scale patterns of population stratification confound rare variant association tests. Plos One. 8: e65834. PMID 23861739 DOI: 10.1371/journal.pone.0065834  0.72
2013 Hider JL, Gittelman RM, Shah T, Edwards M, Rosenbloom A, Akey JM, Parra EJ. Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry. Bmc Evolutionary Biology. 13: 150. PMID 23848512 DOI: 10.1186/1471-2148-13-150  0.72
2013 Fu W, Akey JM. Selection and adaptation in the human genome. Annual Review of Genomics and Human Genetics. 14: 467-89. PMID 23834317 DOI: 10.1146/annurev-genom-091212-153509  0.72
2013 Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, ... ... Akey JM, et al. Great ape genetic diversity and population history. Nature. 499: 471-5. PMID 23823723 DOI: 10.1038/nature12228  0.72
2013 Duggal NK, Fu W, Akey JM, Emerman M. Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations. Virology. 443: 329-37. PMID 23755966 DOI: 10.1016/j.virol.2013.05.016  0.72
2013 Skelly DA, Merrihew GE, Riffle M, Connelly CF, Kerr EO, Johansson M, Jaschob D, Graczyk B, Shulman NJ, Wakefield J, Cooper SJ, Fields S, Noble WS, Muller EG, Davis TN, ... ... Akey JM, et al. Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Research. 23: 1496-504. PMID 23720455 DOI: 10.1101/gr.155762.113  0.72
2013 Connelly CF, Skelly DA, Dunham MJ, Akey JM. Population genomics and transcriptional consequences of regulatory motif variation in globally diverse Saccharomyces cerevisiae strains. Molecular Biology and Evolution. 30: 1605-13. PMID 23619145 DOI: 10.1093/molbev/mst073  0.72
2013 Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, Akey JM. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 493: 216-20. PMID 23201682 DOI: 10.1038/nature11690  0.72
2013 Zhang G, Muglia LJ, Chakraborty R, Akey JM, Williams SM. Signatures of natural selection on genetic variants affecting complex human traits Applied and Translational Genomics. 2: 77-93. DOI: 10.1016/j.atg.2013.10.002  0.72
2012 O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG, Carvill G, Kumar A, Lee C, Ankenman K, Munson J, Hiatt JB, Turner EH, Levy R, O'Day DR, ... ... Akey JM, et al. Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science (New York, N.Y.). 338: 1619-22. PMID 23160955 DOI: 10.1126/science.1227764  0.72
2012 Wong AK, Ruhe AL, Biswas S, Robertson KR, Ali A, Akey JM, Neff MW. Marker panels for genealogy-based mapping, breed demographics, and inference-of-ancestry in the dog. Animal Biotechnology. 23: 241-52. PMID 23134304 DOI: 10.1080/10495398.2012.717151  0.72
2012 Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH. Adaptive evolution of the FADS gene cluster within Africa. Plos One. 7: e44926. PMID 23028684 DOI: 10.1371/journal.pone.0044926  0.72
2012 Vernot B, Stergachis AB, Maurano MT, Vierstra J, Neph S, Thurman RE, Stamatoyannopoulos JA, Akey JM. Personal and population genomics of human regulatory variation. Genome Research. 22: 1689-97. PMID 22955981 DOI: 10.1101/gr.134890.111  0.72
2012 Neph S, Vierstra J, Stergachis AB, Reynolds AP, Haugen E, Vernot B, Thurman RE, John S, Sandstrom R, Johnson AK, Maurano MT, Humbert R, Rynes E, Wang H, Vong S, ... ... Akey JM, et al. An expansive human regulatory lexicon encoded in transcription factor footprints. Nature. 489: 83-90. PMID 22955618 DOI: 10.1038/nature11212  0.72
2012 Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, ... ... Akey JM, et al. The accessible chromatin landscape of the human genome. Nature. 489: 75-82. PMID 22955617 DOI: 10.1038/nature11232  0.72
2012 Lachance J, Vernot B, Elbers CC, Ferwerda B, Froment A, Bodo JM, Lema G, Fu W, Nyambo TB, Rebbeck TR, Zhang K, Akey JM, Tishkoff SA. Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers. Cell. 150: 457-69. PMID 22840920 DOI: 10.1016/j.cell.2012.07.009  0.72
2012 Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Proceedings of the National Academy of Sciences of the United States of America. 109: E2343-52. PMID 22837397 DOI: 10.1073/pnas.1206701109  0.72
2012 Connelly CF, Akey JM. On the prospects of whole-genome association mapping in Saccharomyces cerevisiae. Genetics. 191: 1345-53. PMID 22673807 DOI: 10.1534/genetics.112.141168  0.72
2012 Akey JM. Parallel selection: evolution's surprising predictability. Current Biology : Cb. 22: R407-9. PMID 22625859 DOI: 10.1016/j.cub.2012.04.014  0.72
2012 Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, ... ... Akey JM, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.). 337: 64-9. PMID 22604720 DOI: 10.1126/science.1219240  0.72
2012 O'Roak BJ, Vives L, Girirajan S, Karakoc E, Krumm N, Coe BP, Levy R, Ko A, Lee C, Smith JD, Turner EH, Stanaway IB, Vernot B, Malig M, Baker C, ... ... Akey JM, et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature. 485: 246-50. PMID 22495309 DOI: 10.1038/nature10989  0.72
2012 Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, et al. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. Plos One. 7: e28268. PMID 22295056 DOI: 10.1371/journal.pone.0028268  0.72
2012 Alvarez CE, Akey JM. Copy number variation in the domestic dog. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 144-63. PMID 22138850 DOI: 10.1007/s00335-011-9369-8  0.72
2011 Scheinfeldt LB, Biswas S, Madeoy J, Connelly CF, Akey JM. Clusters of adaptive evolution in the human genome. Frontiers in Genetics. 2: 50. PMID 22303346 DOI: 10.3389/fgene.2011.00050  0.72
2011 Akey JM, Shriver MD. A Grand Challenge in Evolutionary and Population Genetics: New Paradigms for Exploring the Past and Charting the Future in the Post-Genomic era. Frontiers in Genetics. 2: 47. PMID 22303343 DOI: 10.3389/fgene.2011.00047  0.72
2011 Tennessen JA, O'Connor TD, Bamshad MJ, Akey JM. The promise and limitations of population exomics for human evolution studies. Genome Biology. 12: 127. PMID 21920050 DOI: 10.1186/gb-2011-12-9-127  0.72
2011 Skelly DA, Johansson M, Madeoy J, Wakefield J, Akey JM. A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data. Genome Research. 21: 1728-37. PMID 21873452 DOI: 10.1101/gr.119784.110  0.72
2011 Nicholas TJ, Baker C, Eichler EE, Akey JM. A high-resolution integrated map of copy number polymorphisms within and between breeds of the modern domesticated dog. Bmc Genomics. 12: 414. PMID 21846351 DOI: 10.1186/1471-2164-12-414  0.72
2011 Tennessen JA, Akey JM. Parallel adaptive divergence among geographically diverse human populations. Plos Genetics. 7: e1002127. PMID 21698142 DOI: 10.1371/journal.pgen.1002127  0.72
2010 Emery LS, Felsenstein J, Akey JM. Estimators of the human effective sex ratio detect sex biases on different timescales. American Journal of Human Genetics. 87: 848-56. PMID 21109223 DOI: 10.1016/j.ajhg.2010.10.021  0.72
2010 Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, López Herráez D, Brutsaert T, Parra EJ, Moore LG, Shriver MD. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. Plos Genetics. 6: e1001116. PMID 20838600 DOI: 10.1371/journal.pgen.1001116  0.72
2010 Tennessen JA, Madeoy J, Akey JM. Signatures of positive selection apparent in a small sample of human exomes. Genome Research. 20: 1327-34. PMID 20693481 DOI: 10.1101/gr.106161.110  0.72
2010 Lambert CA, Connelly CF, Madeoy J, Qiu R, Olson MV, Akey JM. Highly punctuated patterns of population structure on the X chromosome and implications for African evolutionary history. American Journal of Human Genetics. 86: 34-44. PMID 20085712 DOI: 10.1016/j.ajhg.2009.12.002  0.72
2010 Akey JM, Ruhe AL, Akey DT, Wong AK, Connelly CF, Madeoy J, Nicholas TJ, Neff MW. Tracking footprints of artificial selection in the dog genome. Proceedings of the National Academy of Sciences of the United States of America. 107: 1160-5. PMID 20080661 DOI: 10.1073/pnas.0909918107  0.72
2009 Skelly DA, Ronald J, Connelly CF, Akey JM. Population genomics of intron splicing in 38 Saccharomyces cerevisiae genome sequences. Genome Biology and Evolution. 1: 466-78. PMID 20333215 DOI: 10.1093/gbe/evp046  0.72
2009 Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG, Shriver MD. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Human Genomics. 4: 79-90. PMID 20038496 DOI: 10.1186/1479-7364-4-2-79  0.72
2009 Ko DC, Shukla KP, Fong C, Wasnick M, Brittnacher MJ, Wurfel MM, Holden TD, O'Keefe GE, Van Yserloo B, Akey JM, Miller SI. A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. American Journal of Human Genetics. 85: 214-27. PMID 19664744 DOI: 10.1016/j.ajhg.2009.07.012  0.72
2009 Skelly DA, Ronald J, Akey JM. Inherited variation in gene expression. Annual Review of Genomics and Human Genetics. 10: 313-32. PMID 19630563 DOI: 10.1146/annurev-genom-082908-150121  0.72
2009 Biswas S, Scheinfeldt LB, Akey JM. Genome-wide insights into the patterns and determinants of fine-scale population structure in humans. American Journal of Human Genetics. 84: 641-50. PMID 19442770 DOI: 10.1016/j.ajhg.2009.04.015  0.72
2009 Akey JM. Constructing genomic maps of positive selection in humans: where do we go from here? Genome Research. 19: 711-22. PMID 19411596 DOI: 10.1101/gr.086652.108  0.72
2009 Scheinfeldt LB, Biswas S, Madeoy J, Connelly CF, Schadt EE, Akey JM. Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history. Molecular Biology and Evolution. 26: 1357-67. PMID 19279085 DOI: 10.1093/molbev/msp045  0.72
2009 Yatsenko AS, Kucherenko MM, Pantoja M, Fischer KA, Madeoy J, Deng WM, Schneider M, Baumgartner S, Akey J, Shcherbata HR, Ruohola-Baker H. The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function. Bmc Developmental Biology. 9: 18. PMID 19250553 DOI: 10.1186/1471-213X-9-18  0.72
2009 Nicholas TJ, Cheng Z, Ventura M, Mealey K, Eichler EE, Akey JM. The genomic architecture of segmental duplications and associated copy number variants in dogs. Genome Research. 19: 491-9. PMID 19129542 DOI: 10.1101/gr.084715.108  0.72
2008 Mealey KL, Jabbes M, Spencer E, Akey JM. Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 38: 1305-12. PMID 18841518 DOI: 10.1080/00498250802446146  0.72
2008 Biswas S, Storey JD, Akey JM. Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis. Bmc Bioinformatics. 9: 244. PMID 18492285 DOI: 10.1186/1471-2105-9-244  0.72
2007 Ronald J, Akey JM. The evolution of gene expression QTL in Saccharomyces cerevisiae. Plos One. 2: e678. PMID 17668057 DOI: 10.1371/journal.pone.0000678  0.72
2007 Akey JM, Biswas S, Leek JT, Storey JD. On the design and analysis of gene expression studies in human populations. Nature Genetics. 39: 807-8; author reply . PMID 17597765 DOI: 10.1038/ng0707-807  0.72
2007 Gojobori J, Tang H, Akey JM, Wu CI. Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution. Proceedings of the National Academy of Sciences of the United States of America. 104: 3907-12. PMID 17360451 DOI: 10.1073/pnas.0605565104  0.72
2007 Storey JD, Madeoy J, Strout JL, Wurfel M, Ronald J, Akey JM. Gene-expression variation within and among human populations. American Journal of Human Genetics. 80: 502-9. PMID 17273971 DOI: 10.1086/512017  0.72
2006 Kelley JL, Madeoy J, Calhoun JC, Swanson W, Akey JM. Genomic signatures of positive selection in humans and the limits of outlier approaches. Genome Research. 16: 980-9. PMID 16825663 DOI: 10.1101/gr.5157306  0.72
2006 Biswas S, Akey JM. Genomic insights into positive selection. Trends in Genetics : Tig. 22: 437-46. PMID 16808986 DOI: 10.1016/j.tig.2006.06.005  0.72
2006 Akey JM, Swanson WJ, Madeoy J, Eberle M, Shriver MD. TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations. Human Molecular Genetics. 15: 2106-13. PMID 16717058 DOI: 10.1093/hmg/ddl134  0.72
2006 Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Plos Genetics. 2: e35. PMID 16552446 DOI: 10.1371/journal.pgen.0020035  0.72
2006 Mackelprang R, Livingston RJ, Eberle MA, Carlson CS, Yi Q, Akey JM, Nickerson DA. Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locus. Human Genetics. 119: 255-66. PMID 16425038 DOI: 10.1007/s00439-005-0111-z  0.72
2006 Sawyer SL, Wu LI, Akey JM, Emerman M, Malik HS. High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. Current Biology : Cb. 16: 95-100. PMID 16401428 DOI: 10.1016/j.cub.2005.11.045  0.72
2005 Reed FA, Akey JM, Aquadro CF. Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes. Genome Research. 15: 1211-21. PMID 16140989 DOI: 10.1101/gr.3413205  0.72
2005 Storey JD, Akey JM, Kruglyak L. Multiple locus linkage analysis of genomewide expression in yeast. Plos Biology. 3: e267. PMID 16035920 DOI: 10.1371/journal.pbio.0030267  0.72
2005 Ronald J, Akey JM. Genome-wide scans for loci under selection in humans. Human Genomics. 2: 113-25. PMID 16004726 DOI: 10.1186/1479-7364-2-2-113  0.72
2005 Shriver MD, Mei R, Parra EJ, Sonpar V, Halder I, Tishkoff SA, Schurr TG, Zhadanov SI, Osipova LP, Brutsaert TD, Friedlaender J, Jorde LB, Watkins WS, Bamshad MJ, Gutierrez G, ... ... Akey JM, et al. Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation. Human Genomics. 2: 81-9. PMID 16004724 DOI: 10.1186/1479-7364-2-2-81  0.72
2005 Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Research. 15: 284-91. PMID 15687292 DOI: 10.1101/gr.2850605  0.72
2004 Shriver MD, Kennedy GC, Parra EJ, Lawson HA, Sonpar V, Huang J, Akey JM, Jones KW. The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs. Human Genomics. 1: 274-86. PMID 15588487 DOI: 10.1186/1479-7364-1-4-274  0.72
2004 Jin L, Zhang G, Akey JM, Luo J, Lee J, Weisman MH, Bruckel J, Inman RD, Stone MA, Khan MA, Schumacher HR, Maksymowych WP, Mahowald ML, Sawitzke AD, Vasey FB, et al. Lack of linkage of IL1RN genotypes with ankylosing spondylitis susceptibility. Arthritis and Rheumatism. 50: 3047-8. PMID 15457475 DOI: 10.1002/art.20475  0.72
2004 Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. Population history and natural selection shape patterns of genetic variation in 132 genes. Plos Biology. 2: e286. PMID 15361935 DOI: 10.1371/journal.pbio.0020286  0.72
2003 Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature Genetics. 35: 57-64. PMID 12897782 DOI: 10.1038/ng1222  0.72
2003 Maksymowych WP, Reeve JP, Reveille JD, Akey JM, Buenviaje H, O'Brien L, Peloso PM, Thomson GT, Jin L, Russell AS. High-throughput single-nucleotide polymorphism analysis of the IL1RN locus in patients with ankylosing spondylitis by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Arthritis and Rheumatism. 48: 2011-8. PMID 12847695 DOI: 10.1002/art.11037  0.72
2003 Zhang K, Akey JM, Wang N, Xiong M, Chakraborty R, Jin L. Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift. Human Genetics. 113: 51-9. PMID 12677424 DOI: 10.1007/s00439-003-0941-5  0.72
2003 Akey JM, Zhang K, Xiong M, Jin L. The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibrium. Molecular Biology and Evolution. 20: 232-42. PMID 12598690 DOI: 10.1093/molbev/msg032  0.72
2003 Sun G, McGarvey ST, Bayoumi R, Mulligan CJ, Barrantes R, Raskin S, Zhong Y, Akey J, Chakraborty R, Deka R. Global genetic variation at nine short tandem repeat loci and implications on forensic genetics. European Journal of Human Genetics : Ejhg. 11: 39-49. PMID 12529704 DOI: 10.1038/sj.ejhg.5200902  0.72
2002 Akey JM, Zhang G, Zhang K, Jin L, Shriver MD. Interrogating a high-density SNP map for signatures of natural selection. Genome Research. 12: 1805-14. PMID 12466284 DOI: 10.1101/gr.631202  0.72
2002 Wang N, Akey JM, Zhang K, Chakraborty R, Jin L. Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. American Journal of Human Genetics. 71: 1227-34. PMID 12384857 DOI: 10.1086/344398  0.72
2002 Akey DT, Akey JM, Zhang K, Jin L. Assaying DNA methylation based on high-throughput melting curve approaches. Genomics. 80: 376-84. PMID 12376091 DOI: 10.1006/geno.2002.6851  0.72
2001 Akey JM, Wang H, Xiong M, Wu H, Liu W, Shriver MD, Jin L. Interaction between the melanocortin-1 receptor and P genes contributes to inter-individual variation in skin pigmentation phenotypes in a Tibetan population. Human Genetics. 108: 516-20. PMID 11499678 DOI: 10.1007/s004390100524  0.72
2001 Jiang Z, Akey JM, Shi J, Xiong M, Wang Y, Shen Y, Xu X, Chen H, Wu H, Xiao J, Lu D, Huang W, Jin L. A polymorphism in the promoter region of catalase is associated with blood pressure levels. Human Genetics. 109: 95-8. PMID 11479740 DOI: 10.1007/s004390100553  0.72
2001 Wu H, Wang H, Li H, Akey J, Xiao F, Ke Y, Xu H, Xiao J, Lu D, Parra E, Shriver M, Xiong M, Barton SA, Hewett-Emmett D, Liu W, et al. Skin reflectance in the Han Chinese and Tibetan populations Human Biology. 73: 461-466. PMID 11459426  0.72
2001 Akey JM, Zhang K, Xiong M, Doris P, Jin L. The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures. American Journal of Human Genetics. 68: 1447-56. PMID 11359212 DOI: 10.1086/320607  0.72
2001 Akey J, Jin L, Xiong M. Haplotypes vs single marker linkage disequilibrium tests: what do we gain? European Journal of Human Genetics : Ejhg. 9: 291-300. PMID 11313774 DOI: 10.1038/sj.ejhg.5200619  0.72
2001 Akey JM, Sosnoski D, Parra E, Dios S, Hiester K, Su B, Bonilla C, Jin L, Shriver MD. Melting curve analysis of SNPs (McSNP): a gel-free and inexpensive approach for SNP genotyping. Biotechniques. 30: 358-62, 364, 366-7. PMID 11233605  0.72
2000 Xiong M, Akey J, Jin L. The haplotype linkage disequilibrium test for genome-wide screens: its power and study design. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 675-86. PMID 10902215  0.72
1999 Su B, Xiao J, Underhill P, Deka R, Zhang W, Akey J, Huang W, Shen D, Lu D, Luo J, Chu J, Tan J, Shen P, Davis R, Cavalli-Sforza L, et al. Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. American Journal of Human Genetics. 65: 1718-24. PMID 10577926 DOI: 10.1086/302680  0.72
1998 Parra EJ, Marcini A, Akey J, Martinson J, Batzer MA, Cooper R, Forrester T, Allison DB, Deka R, Ferrell RE, Shriver MD. Estimating African American admixture proportions by use of population-specific alleles. American Journal of Human Genetics. 63: 1839-51. PMID 9837836 DOI: 10.1086/302148  0.72
1997 Shriver MD, Smith MW, Jin L, Marcini A, Akey JM, Deka R, Ferrell RE. Ethnic-affiliation estimation by use of population-specific DNA markers. American Journal of Human Genetics. 60: 957-64. PMID 9106543  0.72
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