Curt D. Sigmund - Publications

Affiliations: 
Molecular Physiology & Biophysics University of Iowa, Iowa City, IA 
Area:
Molecular Biology, Physiology Biology, Cell Biology, Genetics

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Davidge B, de Oliveira Rebola KG, Agbor LN, Sigmund CD, Singer JD. Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E. Journal of Cell Science. PMID 31636116 DOI: 10.1242/jcs.233049  0.32
2019 Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD. Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension. Jci Insight. 5. PMID 31184598 DOI: 10.1172/jci.insight.129793  0.6
2019 Nair AR, Silva SD, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11913. PMID 31104564 DOI: 10.1161/HYPERTENSIONAHA.119.13101  0.36
2019 Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD. RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity. The Journal of Clinical Investigation. 130. PMID 30896450 DOI: 10.1172/JCI123462  0.72
2018 Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD. Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. Hypertension (Dallas, Tex. : 1979). 72: 1227-1235. PMID 30354810 DOI: 10.1161/HYPERTENSIONAHA.118.11857  0.72
2018 Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, ... ... Sigmund CD, et al. Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. Jci Insight. 3. PMID 30282823 DOI: 10.1172/jci.insight.99403  0.52
2018 Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH. Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension. American Journal of Physiology. Renal Physiology. PMID 29897280 DOI: 10.1152/ajprenal.00602.2017  0.32
2018 De Silva TM, Li Y, Kinzenbaw DA, Sigmund CD, Faraci FM. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. Hypertension (Dallas, Tex. : 1979). PMID 29735632 DOI: 10.1161/HYPERTENSIONAHA.117.10799  0.4
2018 Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia. Clinical Science (London, England : 1979). PMID 29371289 DOI: 10.1042/CS20171059  0.36
2018 Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 29364700 DOI: 10.1152/ajpregu.00435.2017  0.36
2017 Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA. Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects. Jci Insight. 2. PMID 29263298 DOI: 10.1172/jci.insight.96700  0.32
2017 Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential Mechanisms of Hypothalamic Renin-Angiotensin System Activation by Leptin and DOCA-salt for the Control of Resting Metabolism. Physiological Genomics. physiolgenomics.0008. PMID 28986397 DOI: 10.1152/physiolgenomics.00087.2017  0.36
2017 Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension (Dallas, Tex. : 1979). PMID 28874461 DOI: 10.1161/HYPERTENSIONAHA.117.09923  0.72
2017 De Silva TM, Hu C, Kinzenbaw DA, Modrick ML, Sigmund CD, Faraci FM. Genetic Interference With Endothelial Peroxisome Proliferator-Activated Receptor-γ Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. Hypertension (Dallas, Tex. : 1979). PMID 28674038 DOI: 10.1161/HYPERTENSIONAHA.117.09358  0.4
2017 Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD. Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle. Hypertension (Dallas, Tex. : 1979). PMID 28507170 DOI: 10.1161/HYPERTENSIONAHA.117.09276  0.72
2017 Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for Intraventricular Secretion of Angiotensinogen and Angiotensin by the Subfornical Organ Using Transgenic Mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00511.2016. PMID 28490451 DOI: 10.1152/ajpregu.00511.2016  0.72
2017 Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD. Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin. Jci Insight. 2: e91738. PMID 28352663 DOI: 10.1172/jci.insight.91738  0.72
2017 Keen HL, Sigmund CD. Microarray Analysis of Hypertension. Methods in Molecular Biology (Clifton, N.J.). 1527: 41-52. PMID 28116705 DOI: 10.1007/978-1-4939-6625-7_3  0.52
2016 Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD. Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. Jci Insight. 1: e91015. PMID 27882355 DOI: 10.1172/jci.insight.91015  0.6
2016 Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension (Dallas, Tex. : 1979). PMID 27754863 DOI: 10.1161/HYPERTENSIONAHA.116.08242  0.72
2016 Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM. Role of CaMKII in Ang-II-dependent small artery remodeling. Vascular Pharmacology. PMID 27658984 DOI: 10.1016/j.vph.2016.09.007  0.36
2016 Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD. Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology. en20161524. PMID 27575030 DOI: 10.1210/en.2016-1524  0.36
2016 Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, ... Sigmund CD, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Reports. PMID 27477281 DOI: 10.1016/j.celrep.2016.07.003  0.72
2016 Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N. Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. Plos One. 11: e0159872. PMID 27467376 DOI: 10.1371/journal.pone.0159872  0.4
2016 Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking but Not Blood Pressure Responses to Brain Angiotensin II. Endocrinology. en20161243. PMID 27254006 DOI: 10.1210/en.2016-1243  0.36
2016 Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD. Effect of Selective Expression of Dominant Negative PPARγ in Proopiomelanocortin Neurons on the Control of Energy Balance. Physiological Genomics. physiolgenomics.0003. PMID 27199455 DOI: 10.1152/physiolgenomics.00032.2016  0.72
2016 Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension. PMID 26928806 DOI: 10.1161/HYPERTENSIONAHA.115.07082  0.52
2016 Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, ... ... Sigmund CD, et al. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension. PMID 26902490 DOI: 10.1161/HYPERTENSIONAHA.115.06433  0.36
2016 Wu J, Sigmund CD. Hypertension: A Disease That Strikes Around the Clock. Hypertension. 67: 493-5. PMID 26781274 DOI: 10.1161/HYPERTENSIONAHA.115.06331  0.32
2016 Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, et al. Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26769049 DOI: 10.1161/ATVBAHA.115.306912  0.52
2015 Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. PMID 26597823 DOI: 10.1161/HYPERTENSIONAHA.115.06391  0.72
2015 Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD. Endothelial PPARγ Provides Vascular Protection from IL-1β-Induced Oxidative Stress. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00490.2015. PMID 26566726 DOI: 10.1152/ajpheart.00490.2015  0.72
2015 Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD. Interference with PPARγ in Endothelium Accelerates Angiotensin II-induced Endothelial Dysfunction. Physiological Genomics. physiolgenomics.0008. PMID 26534936 DOI: 10.1152/physiolgenomics.00087.2015  0.72
2015 Stump M, Mukohda M, Hu C, Sigmund CD. PPARγ Regulation in Hypertension and Metabolic Syndrome. Current Hypertension Reports. 17: 89. PMID 26462805 DOI: 10.1007/s11906-015-0601-x  0.36
2015 Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA. Vascular versus tubular renin: role in kidney development. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R650-7. PMID 26246508 DOI: 10.1152/ajpregu.00313.2015  0.4
2015 Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. The Journal of Biological Chemistry. 290: 19208-17. PMID 26100637 DOI: 10.1074/jbc.M115.645358  0.36
2015 Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II-Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function. Journal of the American Heart Association. 4. PMID 26077587 DOI: 10.1161/JAHA.115.001949  0.36
2015 Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD. Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. Hypertension. 66: 211-20. PMID 25916724 DOI: 10.1161/HYPERTENSIONAHA.115.05332  0.4
2015 Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. Hypertension. 65: 1341-8. PMID 25895586 DOI: 10.1161/HYPERTENSIONAHA.115.05377  0.72
2015 Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: the missing link for preeclampsia? American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R1062-4. PMID 25810383 DOI: 10.1152/ajpregu.00073.2015  0.36
2015 Jin H, Gebska MA, Blokhin IO, Wilson KM, Ketsawatsomkron P, Chauhan AK, Keen HL, Sigmund CD, Lentz SR. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 838-44. PMID 25675995 DOI: 10.1161/ATVBAHA.115.305378  0.52
2015 Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiological Reports. 3. PMID 25602015 DOI: 10.14814/phy2.12257  0.6
2015 Ketsawatsomkron P, Sigmund CD. Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma. Current Opinion in Nephrology and Hypertension. 24: 123-30. PMID 25587903 DOI: 10.1097/MNH.0000000000000103  0.72
2015 Coble JP, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R238-49. PMID 25519738 DOI: 10.1152/ajpregu.00486.2014  0.72
2015 Sequeira-Lopez ML, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA. The earliest metanephric arteriolar progenitors and their role in kidney vascular development. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R138-49. PMID 25427768 DOI: 10.1152/ajpregu.00428.2014  0.72
2015 De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM. Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. Hypertension. 65: 345-51. PMID 25385762 DOI: 10.1161/HYPERTENSIONAHA.114.04541  0.72
2014 Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. Hypertension. 64: 1182-3. PMID 25225201 DOI: 10.1161/HYPERTENSIONAHA.114.04075  0.36
2014 De Silva TM, Modrick ML, Ketsawatsomkron P, Lynch C, Chu Y, Pelham CJ, Sigmund CD, Faraci FM. Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation. Hypertension. 64: 1088-93. PMID 25185134 DOI: 10.1161/HYPERTENSIONAHA.114.03935  0.72
2014 Ramkumar N, Stuart D, Rees S, Hoek AV, Sigmund CD, Kohan DE. Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. American Journal of Physiology. Renal Physiology. 307: F931-8. PMID 25122048 DOI: 10.1152/ajprenal.00367.2014  0.72
2014 Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. Plos One. 9: e103786. PMID 25122005 DOI: 10.1371/journal.pone.0103786  0.72
2014 Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R376-86. PMID 24965793 DOI: 10.1152/ajpregu.00216.2014  0.72
2014 Borges GR, Morgan DA, Ketsawatsomkron P, Mickle AD, Thompson AP, Cassell MD, Mohapatra DP, Rahmouni K, Sigmund CD. Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. Hypertension. 64: 590-6. PMID 24914194 DOI: 10.1161/HYPERTENSIONAHA.114.03553  0.72
2014 Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. Hypertension. 64: 141-8. PMID 24777977 DOI: 10.1161/HYPERTENSIONAHA.114.03461  0.72
2013 Prasad AM, Nuno DW, Koval OM, Ketsawatsomkron P, Li W, Li H, Shen FY, Joiner ML, Kutschke W, Weiss RM, Sigmund CD, Anderson ME, Lamping KG, Grumbach IM. Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. Hypertension. 62: 434-41. PMID 23753415 DOI: 10.1161/HYPERTENSIONAHA.113.01508  0.72
2013 Park S, Lu KT, Liu X, Chatterjee TK, Rudich SM, Weintraub NL, Kwitek AE, Sigmund CD. Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. Hypertension. 62: 41-7. PMID 23648704 DOI: 10.1161/HYPERTENSIONAHA.113.01330  0.72
2013 Littlejohn NK, Siel RB, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R818-28. PMID 23535460 DOI: 10.1152/ajpregu.00082.2013  0.72
2013 Pelham CJ, Keen HL, Lentz SR, Sigmund CD. Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R690-701. PMID 23447133 DOI: 10.1152/ajpregu.00607.2012  0.72
2013 Chu Y, Lund DD, Weiss RM, Brooks RM, Doshi H, Hajj GP, Sigmund CD, Heistad DD. Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 523-32. PMID 23288158 DOI: 10.1161/ATVBAHA.112.300794  0.72
2013 Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension. 61: 716-22. PMID 23266541 DOI: 10.1161/HYPERTENSIONAHA.111.00356  0.72
2013 Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body. PflüGers Archiv : European Journal of Physiology. 465: 167-75. PMID 22491893 DOI: 10.1007/s00424-012-1096-9  0.72
2012 Cai J, Keen HL, Sigmund CD, Casavant TL. Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. Journal of Integrative Bioinformatics. 9: 32-43. PMID 29220886 DOI: 10.1515/jib-2012-208  0.52
2012 Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD. Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metabolism. 16: 462-72. PMID 23040068 DOI: 10.1016/j.cmet.2012.08.011  0.72
2012 Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circulation Research. 111: 1446-58. PMID 22962432 DOI: 10.1161/CIRCRESAHA.112.271577  0.72
2012 Cai J, Keen HL, Sigmund CD, Casavant TL. Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. Journal of Integrative Bioinformatics. 9: 208. PMID 22842118 DOI: 10.2390/biecoll-jib-2012-208  0.72
2012 Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. American Journal of Physiology. Heart and Circulatory Physiology. 303: H197-206. PMID 22610169 DOI: 10.1152/ajpheart.00974.2011  0.72
2012 Park S, Liu X, Davis DR, Sigmund CD. Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. Hypertension. 59: 1212-9. PMID 22547438 DOI: 10.1161/HYPERTENSIONAHA.112.192971  0.72
2012 Modrick ML, Kinzenbaw DA, Chu Y, Sigmund CD, Faraci FM. Peroxisome proliferator-activated receptor-γ protects against vascular aging. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R1184-90. PMID 22461176 DOI: 10.1152/ajpregu.00557.2011  0.4
2012 Weatherford ET, Liu X, Sigmund CD. Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6. American Journal of Physiology. Renal Physiology. 302: F1025-33. PMID 22278040 DOI: 10.1152/ajprenal.00362.2011  0.72
2012 Norris AW, Sigmund CD. A second chance for a PPARγ targeted therapy? Circulation Research. 110: 8-11. PMID 22223206 DOI: 10.1161/RES.0b013e3182435d88  0.72
2011 He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine. 17: 1610-8. PMID 22081025 DOI: 10.1038/nm.2506  0.72
2011 Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R1067-77. PMID 21753145 DOI: 10.1152/ajpregu.00124.2011  0.72
2011 Rahmouni K, Davisson RL, Sigmund CD. Inflaming hypothalamic neurons raises blood pressure. Cell Metabolism. 14: 3-4. PMID 21723497 DOI: 10.1016/j.cmet.2011.06.006  0.72
2011 Harlan SM, Morgan DA, Agassandian K, Guo DF, Cassell MD, Sigmund CD, Mark AL, Rahmouni K. Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circulation Research. 108: 808-12. PMID 21311043 DOI: 10.1161/CIRCRESAHA.111.240226  0.72
2011 Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. Hypertension. 57: 600-7. PMID 21263123 DOI: 10.1161/HYPERTENSIONAHA.110.165829  0.72
2011 Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiological Genomics. 43: 286-94. PMID 21189370 DOI: 10.1152/physiolgenomics.00208.2010  0.72
2010 Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metabolism. 12: 431-42. PMID 21035755 DOI: 10.1016/j.cmet.2010.09.011  0.72
2010 Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension. 56: 981-7. PMID 20823378 DOI: 10.1161/HYPERTENSIONAHA.110.157354  0.72
2010 Gross KW, Gomez RA, Sigmund CD. Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298: R1209-11. PMID 20237305 DOI: 10.1152/ajpregu.00188.2010  0.72
2010 Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD. Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature? The Journal of Biological Chemistry. 285: 9311-6. PMID 20129921 DOI: 10.1074/jbc.R109.025031  0.72
2010 Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT. Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells. Hypertension. 55: 660-6. PMID 20065157 DOI: 10.1161/HYPERTENSIONAHA.109.138800  0.72
2010 Sequeira-Lopez ML, Weatherford ET, Borges GR, Monteagudo MC, Pentz ES, Harfe BD, Carretero O, Sigmund CD, Gomez RA. The microRNA-processing enzyme dicer maintains juxtaglomerular cells. Journal of the American Society of Nephrology : Jasn. 21: 460-7. PMID 20056748 DOI: 10.1681/ASN.2009090964  0.72
2010 Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD. Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 518-25. PMID 20018933 DOI: 10.1161/ATVBAHA.109.200733  0.72
2010 Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circulation Research. 106: 373-82. PMID 19926873 DOI: 10.1161/CIRCRESAHA.109.208645  0.72
2009 Santillan MK, Santillan DA, Sigmund CD, Hunter SK. From molecules to medicine: a future cure for preeclampsia? Drug News & Perspectives. 22: 531-41. PMID 20072730 DOI: 10.1358/dnp.2009.22.9.1435464  0.72
2009 Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 54: 1240-7. PMID 19822797 DOI: 10.1161/HYPERTENSIONAHA.109.138677  0.72
2009 Bianco RA, Agassandian K, Cassell MD, Spector AA, Sigmund CD. Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. Brain Research. 1291: 60-72. PMID 19643090 DOI: 10.1016/j.brainres.2009.07.060  0.72
2009 Itani H, Liu X, Sarsour EH, Goswami PC, Born E, Keen HL, Sigmund CD. Regulation of renin gene expression by oxidative stress. Hypertension. 53: 1070-6. PMID 19433777 DOI: 10.1161/HYPERTENSIONAHA.109.130633  0.72
2009 Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1914-9. PMID 19395552 DOI: 10.1152/ajpheart.00300.2009  0.4
2009 Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R1325-6. PMID 19261916 DOI: 10.1152/ajpregu.00123.2009  0.36
2008 Harlan SM, Reiter RS, Sigmund CD, Lin JL, Lin JJ. Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice. Anatomical Record (Hoboken, N.J. : 2007). 291: 1574-86. PMID 18951515 DOI: 10.1002/ar.20772  0.72
2008 Dickson ME, Tian X, Liu X, Davis DR, Sigmund CD. Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism. Circulation Research. 103: 940-7. PMID 18802024 DOI: 10.1161/CIRCRESAHA.108.180653  0.72
2008 Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda, Md.). 23: 187-93. PMID 18697992 DOI: 10.1152/physiol.00002.2008  0.36
2008 Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circulation Research. 103: 654-61. PMID 18676352 DOI: 10.1161/CIRCRESAHA.108.176339  0.72
2008 Zhou X, Weatherford ET, Liu X, Born E, Keen HL, Sigmund CD. Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. American Journal of Physiology. Renal Physiology. 295: F642-53. PMID 18632798 DOI: 10.1152/ajprenal.00384.2007  0.72
2008 de Lange WJ, Halabi CM, Beyer AM, Sigmund CD. Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiological Genomics. 35: 1-4. PMID 18612081 DOI: 10.1152/physiolgenomics.90284.2008  0.72
2008 Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B. Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. American Journal of Physiology. Renal Physiology. 295: F462-70. PMID 18524855 DOI: 10.1152/ajprenal.90300.2008  0.72
2008 Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. American Journal of Physiology. Renal Physiology. 294: F1481-6. PMID 18385272 DOI: 10.1152/ajprenal.00064.2008  0.72
2008 Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metabolism. 7: 215-26. PMID 18316027 DOI: 10.1016/j.cmet.2007.12.008  0.72
2008 Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD. Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1175-85. PMID 18301433 DOI: 10.1038/jcbfm.2008.7  0.4
2008 Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension. 51: 867-71. PMID 18285614 DOI: 10.1161/HYPERTENSIONAHA.107.103648  0.72
2008 Zhou X, Sigmund CD. Chorionic enhancer is dispensable for regulated expression of the human renin gene. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R279-87. PMID 18077515 DOI: 10.1152/ajpregu.00780.2007  0.96
2007 Weatherford ET, Itani H, Keen HL, Sigmund CD. Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin? Hypertension. 50: 844-6. PMID 17785627 DOI: 10.1161/HYPERTENSIONAHA.107.097519  0.72
2007 Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD. Local production of angiotensin II in the subfornical organ causes elevated drinking. The Journal of Clinical Investigation. 117: 1088-95. PMID 17404622 DOI: 10.1172/JCI31242  0.72
2007 Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Developmental Biology. 305: 90-102. PMID 17335794 DOI: 10.1016/j.ydbio.2007.01.038  0.72
2007 Itani HA, Liu X, Pratt JH, Sigmund CD. Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology. 148: 1424-30. PMID 17158202 DOI: 10.1210/en.2006-1381  0.72
2007 McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. Journal of Virology. 81: 813-21. PMID 17079315 DOI: 10.1128/JVI.02012-06  0.72
2006 Sinnayah P, Lazartigues E, Sakai K, Sharma RV, Sigmund CD, Davisson RL. Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circulation Research. 99: 1125-31. PMID 17053195 DOI: 10.1161/01.RES.0000250259.66683.f5  0.72
2006 Zhou X, Davis DR, Sigmund CD. The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. The Journal of Biological Chemistry. 281: 35296-304. PMID 16990260 DOI: 10.1074/jbc.M608055200  0.96
2006 Liu X, Shi Q, Sigmund CD. Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells. Endocrinology. 147: 6011-8. PMID 16959849 DOI: 10.1210/en.2006-0129  0.72
2006 Cao XR, Shi PP, Sigmund RD, Husted RF, Sigmund CD, Williamson RA, Stokes JB, Yang B. Mice heterozygous for beta-ENaC deletion have defective potassium excretion. American Journal of Physiology. Renal Physiology. 291: F107-15. PMID 16571596 DOI: 10.1152/ajprenal.00159.2005  0.36
2006 Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD. Evidence supporting a functional role for intracellular renin in the brain. Hypertension. 47: 461-6. PMID 16446393 DOI: 10.1161/01.HYP.0000203308.52919.dc  0.72
2006 Kiss PJ, Knisz J, Zhang Y, Baltrusaitis J, Sigmund CD, Thalmann R, Smith RJ, Verpy E, Bánfi B. Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Current Biology : Cb. 16: 208-13. PMID 16431374 DOI: 10.1016/j.cub.2005.12.025  0.72
2006 Sigmund CD, Davisson RL. Targeting brain AT1 receptors by RNA interference. Hypertension. 47: 145-6. PMID 16380514 DOI: 10.1161/01.HYP.0000200278.64801.4e  0.72
2006 Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Sigmund CD, Didion SP. Cerebral vascular effects of angiotensin II: new insights from genetic models. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 449-55. PMID 16094317 DOI: 10.1038/sj.jcbfm.9600204  0.4
2005 Halabi CM, Sigmund CD. Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions. 5: 389-98. PMID 16259527 DOI: 10.2165/00129784-200505060-00006  0.72
2005 Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD. Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1763-9. PMID 16109805 DOI: 10.1152/ajpregu.00435.2005  0.72
2005 Iida S, Baumbach GL, Lavoie JL, Faraci FM, Sigmund CD, Heistad DD. Spontaneous stroke in a genetic model of hypertension in mice. Stroke; a Journal of Cerebral Circulation. 36: 1253-8. PMID 15914769 DOI: 10.1161/01.str.0000167694.58419.a2  0.4
2005 Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC. Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Human Molecular Genetics. 14: 1109-18. PMID 15772095 DOI: 10.1093/hmg/ddi123  0.72
2005 Sherrod M, Liu X, Zhang X, Sigmund CD. Nuclear localization of angiotensinogen in astrocytes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R539-46. PMID 15388495 DOI: 10.1152/ajpregu.00594.2004  0.72
2004 Sakai K, Chapleau MW, Morimoto S, Cassell MD, Sigmund CD. Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. Physiological Genomics. 20: 66-72. PMID 15467015 DOI: 10.1152/physiolgenomics.00168.2004  0.72
2004 Baumbach GL, Sigmund CD, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circulation Research. 95: 822-9. PMID 15388643 DOI: 10.1161/01.RES.0000146279.11923.14  0.4
2004 Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. The Journal of Clinical Investigation. 114: 652-8. PMID 15343383 DOI: 10.1172/JCI21737  0.72
2004 Stunz LL, Busch LK, Munroe ME, Sigmund CD, Tygrett LT, Waldschmidt TJ, Bishop GA. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity. 21: 255-66. PMID 15308105 DOI: 10.1016/j.immuni.2004.07.008  0.72
2004 Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng N, Sigmund CD, Engelhardt JF. Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. The Journal of Investigative Dermatology. 123: 264-74. PMID 15245424 DOI: 10.1111/j.0022-202X.2004.23201.x  0.72
2004 Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L752-63. PMID 15194563 DOI: 10.1152/ajplung.00026.2004  0.72
2004 Dayal S, Arning E, Bottiglieri T, Böger RH, Sigmund CD, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke; a Journal of Cerebral Circulation. 35: 1957-62. PMID 15178827 DOI: 10.1161/01.STR.0000131749.81508.18  0.52
2004 Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 109: 2221-6. PMID 15117840 DOI: 10.1161/01.CIR.0000127956.43874.F2  0.72
2004 Keen HL, Ryan MJ, Beyer A, Mathur S, Scheetz TE, Gackle BD, Faraci FM, Casavant TL, Sigmund CD. Gene expression profiling of potential PPARgamma target genes in mouse aorta. Physiological Genomics. 18: 33-42. PMID 15054141 DOI: 10.1152/physiolgenomics.00027.2004  0.72
2004 Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension. 43: 1116-9. PMID 15037561 DOI: 10.1161/01.HYP.0000125143.73301.94  0.72
2004 Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension. 43: 1074-9. PMID 15007032 DOI: 10.1161/01.HYP.0000123074.89717.3d  0.4
2004 Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proceedings of the National Academy of Sciences of the United States of America. 101: 3621-6. PMID 14988500 DOI: 10.1073/pnas.0308753101  0.72
2004 Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension. 43: 661-6. PMID 14744930 DOI: 10.1161/01.HYP.0000116303.71408.c2  0.4
2004 Nistala R, Zhang X, Sigmund CD. Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. Physiological Genomics. 17: 4-10. PMID 14709678 DOI: 10.1152/physiolgenomics.00205.2003  0.32
2004 Ma X, Sigmund CD, Hingtgen SD, Tian X, Davisson RL, Abboud FM, Chapleau MW. Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. Hypertension. 43: 312-6. PMID 14699002 DOI: 10.1161/01.HYP.0000111835.16662.43  0.72
2004 Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiological Genomics. 16: 240-6. PMID 14625376 DOI: 10.1152/physiolgenomics.00131.2003  0.72
2003 Chen CC, Lamping KG, Nuno DW, Barresi R, Prouty SJ, Lavoie JL, Cribbs LL, England SK, Sigmund CD, Weiss RM, Williamson RA, Hill JA, Campbell KP. Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (New York, N.Y.). 302: 1416-8. PMID 14631046 DOI: 10.1126/science.1089268  0.72
2001 Shi Q, Gross KW, Sigmund CD. NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension. 38: 332-6. PMID 11566900  0.72
2001 Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. The Journal of Biological Chemistry. 276: 45530-8. PMID 11564732 DOI: 10.1074/jbc.M103010200  0.72
2001 Ding Y, Sigmund CD. Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. American Journal of Physiology. Renal Physiology. 280: F54-60. PMID 11133514  0.92
2001 Ding Y, Stec DE, Sigmund CD. Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. The Journal of Biological Chemistry. 276: 7431-6. PMID 11096065 DOI: 10.1074/jbc.M003892200  0.92
2001 Shi Q, Gross KW, Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. The Journal of Biological Chemistry. 276: 3597-603. PMID 11058598 DOI: 10.1074/jbc.M008361200  0.72
1999 Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiological Genomics. 1: 3-9. PMID 11015555  0.72
1999 Shi Q, Black TA, Gross KW, Sigmund CD. Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circulation Research. 85: 479-88. PMID 10488050  0.72
1997 Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. The Journal of Biological Chemistry. 272: 28142-8. PMID 9346970 DOI: 10.1074/jbc.272.44.28142  0.72
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