Nicolas L. Young, Ph.D. - Publications

2016- Biochemistry Baylor College of Medicine, Houston, TX 
Analytical Chemistry, Mass Spectrometry, Epigenetics

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Holt MV, Wang T, Young NL. One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4. Journal of the American Society For Mass Spectrometry. 30: 2514-2525. PMID 31944734 DOI: 10.1021/jasms.8b06270  1
2019 Holt MV, Wang T, Young NL. High-Throughput Quantitative Top-Down Proteomics: Histone H4. Journal of the American Society For Mass Spectrometry. 30: 2548-2560. PMID 31944710 DOI: 10.1021/jasms.8b06303  1
2019 Holt MV, Wang T, Young NL. High-Throughput Quantitative Top-Down Proteomics: Histone H4. Journal of the American Society For Mass Spectrometry. PMID 31741267 DOI: 10.1007/s13361-019-02350-z  1
2019 Holt MV, Wang T, Young NL. One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4. Journal of the American Society For Mass Spectrometry. PMID 31147891 DOI: 10.1007/s13361-019-02219-1  1
2018 Graham BW, Bougoulias ME, Dodge KL, Thaxton CT, Olaso D, Tao Y, Young NL, Marshall AG, Trakselis MA. Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase. Biochemistry. PMID 30199238 DOI: 10.1021/acs.biochem.8b00766  1
2018 Wang T, Holt MV, Young NL. Early Butyrate Induced Acetylation of Histone H4 is Proteoform Specific and Linked to Methylation State. Epigenetics. PMID 29940793 DOI: 10.1080/15592294.2018.1475979  1
2018 Wang T, Holt MV, Young NL. The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance. Epigenetics & Chromatin. 11: 29. PMID 29880017 DOI: 10.1186/s13072-018-0198-9  1
2018 Jiang T, Hoover ME, Holt MV, Freitas MA, Marshall AG, Young NL. Middle-Down Characterization of the Cell Cycle Dependence of Histone H4 Post-Translational Modifications and Proteoforms. Proteomics. e1700442. PMID 29667342 DOI: 10.1002/pmic.201700442  1
2018 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, ... ... Young NL, et al. How many human proteoforms are there? Nature Chemical Biology. 14: 206-214. PMID 29443976 DOI: 10.1038/nchembio.2576  1
2017 Tao Y, Fang P, Kim S, Guo M, Young NL, Marshall AG. Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry. Plos One. 12: e0181869. PMID 28797100 DOI: 10.1371/journal.pone.0181869  1
2017 Fan Y, Guo YR, Yuan W, Zhou Y, Holt MV, Wang T, Demeler B, Young NL, Zhong W, Tao YJ. Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells. Plos Pathogens. 13: e1006231. PMID 28241071 DOI: 10.1371/journal.ppat.1006231  1
2016 Guan X, Brownstein NC, Young NL, Marshall AG. Ultrahigh Resolution FT-ICR MS and MS/MS for Peptide de Novo Amino Acid Sequencing for a Seven-Protein Mixture by Paired Single-Residue Transposed Lys-N and Lys-C Digestion. Rapid Communications in Mass Spectrometry : Rcm. PMID 27813191 DOI: 10.1002/rcm.7783  1
2016 Dang X, Singh A, Spetman BD, Nolan KD, Isaacs JS, Dennis JH, Dalton S, Marshall AG, Young NL. Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS. Journal of Proteome Research. PMID 27431976 DOI: 10.1021/acs.jproteome.6b00414  1
2016 Graham BW, Tao Y, Dodge KL, Thaxton CT, Olaso D, Young NL, Marshall AG, Trakselis MA. DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase. The Journal of Biological Chemistry. PMID 27044751 DOI: 10.1074/jbc.M116.719591  1
2015 Brownstein NC, Guan X, Mao Y, Zhang Q, DiMaggio PA, Xia Q, Zhang L, Marshall AG, Young NL. Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing. Rapid Communications in Mass Spectrometry : Rcm. 29: 659-66. PMID 26212284 DOI: 10.1002/rcm.7137  1
2015 Chen Y, Hoover ME, Dang X, Shomo AA, Guan X, Marshall AG, Freitas MA, Young NL. Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence. Molecular & Cellular Proteomics : McP. PMID 26209608 DOI: 10.1074/mcp.M114.046441  1
2015 Guan X, Noble KA, Tao Y, Roux KH, Sathe SK, Young NL, Marshall AG. Epitope mapping of 7S cashew antigen in complex with antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry. Journal of Mass Spectrometry : Jms. 50: 812-9. PMID 26169135 DOI: 10.1002/jms.3589  1
2015 Askenasy I, Pennington JM, Tao Y, Marshall AG, Young NL, Shang W, Stroupe ME. The N-terminal Domain of Escherichia coli Assimilatory NADPH-Sulfite Reductase Hemoprotein is an Oligomerization Domain that Mediates Holoenzyme Assembly. The Journal of Biological Chemistry. PMID 26088143 DOI: 10.1074/jbc.M115.662379  1
2014 Dang X, Young NL. Ultraviolet photodissociation enhances top-down mass spectrometry as demonstrated on green fluorescent protein variants. Proteomics. 14: 1128-9. PMID 24723542 DOI: 10.1002/pmic.201400114  1
2014 Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, ... ... Young NL, et al. The first pilot project of the consortium for top-down proteomics: a status report. Proteomics. 14: 1130-40. PMID 24644084 DOI: 10.1002/pmic.201300438  1
2014 Ficarro SB, Biagi JM, Wang J, Scotcher J, Koleva RI, Card JD, Adelmant G, He H, Askenazi M, Marshall AG, Young NL, Gray NS, Marto JA. Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents. Journal of the American Society For Mass Spectrometry. 25: 636-50. PMID 24496597 DOI: 10.1007/s13361-013-0811-x  1
2014 Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, Young NL, Guo M, Cho HY, Mushtaq AU, Jeon YH, Choi JW, Han JM, Kang HW, Joo JE, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nature Chemical Biology. 10: 29-34. PMID 24212136 DOI: 10.1038/nchembio.1381  1
2013 Harshman SW, Young NL, Parthun MR, Freitas MA. H1 histones: current perspectives and challenges. Nucleic Acids Research. 41: 9593-609. PMID 23945933 DOI: 10.1093/nar/gkt700  1
2013 Zhang Q, Noble KA, Mao Y, Young NL, Sathe SK, Roux KH, Marshall AG. Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry. Journal of the American Society For Mass Spectrometry. 24: 1016-25. PMID 23681851 DOI: 10.1007/s13361-013-0644-7  1
2013 Zhang Q, Chen J, Kuwajima K, Zhang HM, Xian F, Young NL, Marshall AG. Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry. Scientific Reports. 3: 1247. PMID 23409238 DOI: 10.1038/srep01247  1
2012 Voigt P, LeRoy G, Drury WJ, Zee BM, Son J, Beck DB, Young NL, Garcia BA, Reinberg D. Asymmetrically modified nucleosomes. Cell. 151: 181-93. PMID 23021224 DOI: 10.1016/j.cell.2012.09.002  1
2012 Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 487: 114-8. PMID 22722849 DOI: 10.1038/nature11043  1
2012 Green EM, Mas G, Young NL, Garcia BA, Gozani O. Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nature Structural & Molecular Biology. 19: 361-3. PMID 22343720 DOI: 10.1038/nsmb.2252  1
2011 Zee BM, Young NL, Garcia BA. Quantitative proteomic approaches to studying histone modifications. Current Chemical Genomics. 5: 106-14. PMID 21966350 DOI: 10.2174/1875397301005010106  1
2011 Torrente MP, Zee BM, Young NL, Baliban RC, LeRoy G, Floudas CA, Hake SB, Garcia BA. Proteomic interrogation of human chromatin. Plos One. 6: e24747. PMID 21935452 DOI: 10.1371/journal.pone.0024747  1
2011 Waldmann T, Izzo A, Kamieniarz K, Richter F, Vogler C, Sarg B, Lindner H, Young NL, Mittler G, Garcia BA, Schneider R. Methylation of H2AR29 is a novel repressive PRMT6 target. Epigenetics & Chromatin. 4: 11. PMID 21774791 DOI: 10.1186/1756-8935-4-11  1
2011 Yan K, Cao Q, Reilly CM, Young NL, Garcia BA, Mishra N. Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity. The Journal of Biological Chemistry. 286: 28833-43. PMID 21708950 DOI: 10.1074/jbc.M111.233932  1
2011 Young NL, Garcia BA. Chapter 4: Liquid chromatography-mass spectrometry of intact proteins Rsc Chromatography Monographs. 38-55.  1
2010 Young NL, Dimaggio PA, Garcia BA. The significance, development and progress of high-throughput combinatorial histone code analysis. Cellular and Molecular Life Sciences : Cmls. 67: 3983-4000. PMID 20683756 DOI: 10.1007/s00018-010-0475-7  1
2010 Plazas-Mayorca MD, Bloom JS, Zeissler U, Leroy G, Young NL, DiMaggio PA, Krugylak L, Schneider R, Garcia BA. Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown. Molecular Biosystems. 6: 1719-29. PMID 20577673 DOI: 10.1039/c003307c  1
2010 Young NL, Plazas-Mayorca MD, DiMaggio PA, Flaniken IZ, Beltran AJ, Mishra N, LeRoy G, Floudas CA, Garcia BA. Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a. Journal of the American Society For Mass Spectrometry. 21: 960-70. PMID 20202861 DOI: 10.1016/j.jasms.2010.01.020  1
2010 Young NL, Plazas-Mayorca MD, Garcia BA. Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Review of Proteomics. 7: 79-92. PMID 20121478 DOI: 10.1586/epr.09.100  1
2010 Baliban RC, DiMaggio PA, Plazas-Mayorca MD, Young NL, Garcia BA, Floudas CA. A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry. Molecular & Cellular Proteomics : McP. 9: 764-79. PMID 20103568 DOI: 10.1074/mcp.M900487-MCP200  1
2009 Plazas-Mayorca MD, Zee BM, Young NL, Fingerman IM, LeRoy G, Briggs SD, Garcia BA. One-pot shotgun quantitative mass spectrometry characterization of histones. Journal of Proteome Research. 8: 5367-74. PMID 19764812 DOI: 10.1021/pr900777e  1
2009 DiMaggio PA, Young NL, Baliban RC, Garcia BA, Floudas CA. A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry. Molecular & Cellular Proteomics : McP. 8: 2527-43. PMID 19666874 DOI: 10.1074/mcp.M900144-MCP200  1
2009 Young NL, DiMaggio PA, Plazas-Mayorca MD, Baliban RC, Floudas CA, Garcia BA. High throughput characterization of combinatorial histone codes. Molecular & Cellular Proteomics : McP. 8: 2266-84. PMID 19654425 DOI: 10.1074/mcp.M900238-MCP200  1
2009 LeRoy G, Weston JT, Zee BM, Young NL, Plazas-Mayorca MD, Garcia BA. Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Molecular & Cellular Proteomics : McP. 8: 2432-42. PMID 19567367 DOI: 10.1074/mcp.M900160-MCP200  1
2009 Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Molecular Cell. 33: 417-27. PMID 19250903 DOI: 10.1016/j.molcel.2009.02.004  1
2009 El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Molecular and Cellular Biology. 29: 1959-71. PMID 19158276 DOI: 10.1128/MCB.01862-08  1
2009 Young NL, Plazas-Mayorca MD, Garcia BA. A method to separate and characterize modified forms of histones using HILIC and electron transfer dissociation-mass spectrometry American Biotechnology Laboratory. 27: 23-25.  1
2009 Plazas-Mayorca MD, Young NL, Garcia BA. Identification of differentially expressed histone codes using HILIC and mass spectromety American Biotechnology Laboratory. 27: 10-12.  1
2007 Young NL, Sisto MC, Young MN, Grant PG, Killilea DW, LaMotte L, Wu KJ, Lebrilla CB. Steady-state asymmetric nanospray dual ion source for accurate mass determination within a chromatographic separation. Analytical Chemistry. 79: 5711-8. PMID 17614364 DOI: 10.1021/ac070446z  1
2006 Lee S, Young NL, Whetstone PA, Cheal SM, Benner WH, Lebrilla CB, Meares CF. Method to site-specifically identify and quantitate carbonyl end products of protein oxidation using oxidation-dependent element coded affinity tags (O-ECAT) and nanoliquid chromatography Fourier transform mass spectrometry. Journal of Proteome Research. 5: 539-47. PMID 16512668 DOI: 10.1021/pr050299q  1
2005 Ramanan AV, Schneider R, Batthish M, Achonu C, Ota S, McLimont M, Young NL, Feldman BM. Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach Rheumatology. 44: 1574-1578. PMID 16159950 DOI: 10.1093/rheumatology/kei095  1
2005 Batthish M, Schneider R, Ramanan AV, Achonu C, Young NL, Feldman BM. What does 'active disease' mean? Patient and parent perceptions of disease activity in the systemic arthritis form of juvenile idiopathic arthritis (SO-JIA) Rheumatology. 44: 796-799. PMID 15784631 DOI: 10.1093/rheumatology/keh597  1
1999 Chen J, Young NL, Subbarao S, Warachit P, Saguanwongse S, Wongsheree S, Jayavasu C, Luo CC, Mastro TD. HIV type 1 subtypes in Guangxi Province, China, 1996 Aids Research and Human Retroviruses. 15: 81-84. PMID 10024057 DOI: 10.1089/088922299311754  1
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