Patrick L. Wintrode - Publications

Affiliations: 
Physiology and Biophysics Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Virology Biology, Molecular Biology, Pharmacy

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Tsutsui Y, Deredge D, Wintrode PL, Hays FA. Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy. Scientific Reports. 6: 30832. PMID 27480221 DOI: 10.1038/srep30832  0.56
2016 Deredge D, Li J, Johnson KA, Wintrode PL. Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase. The Journal of Biological Chemistry. PMID 27006396 DOI: 10.1074/jbc.M115.708370  0.56
2015 Lupton CJ, Steer DL, Wintrode PL, Bottomley SP, Hughes VA, Ellisdon AM. Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease. The Journal of Biological Chemistry. 290: 24190-200. PMID 26260925 DOI: 10.1074/jbc.M115.659532  0.56
2015 White MR, Khan MM, Deredge D, Ross CR, Quintyn R, Zucconi BE, Wysocki VH, Wintrode PL, Wilson GM, Garcin ED. A dimer interface mutation in glyceraldehyde 3-phosphate dehydrogenase regulates its binding to AU-rich RNA. The Journal of Biological Chemistry. 290: 4129. PMID 25681510 DOI: 10.1074/jbc.A114.618165  0.56
2015 White MR, Khan MM, Deredge D, Ross CR, Quintyn R, Zucconi BE, Wysocki VH, Wintrode PL, Wilson GM, Garcin ED. A dimer interface mutation in glyceraldehyde-3-phosphate dehydrogenase regulates its binding to AU-rich RNA. The Journal of Biological Chemistry. 290: 1770-85. PMID 25451934 DOI: 10.1074/jbc.M114.618165  0.56
2014 Cazzolli G, Wang F, a Beccara S, Gershenson A, Faccioli P, Wintrode PL. Serpin latency transition at atomic resolution. Proceedings of the National Academy of Sciences of the United States of America. 111: 15414-9. PMID 25313058 DOI: 10.1073/pnas.1407528111  0.56
2014 Hughes VA, Meklemburg R, Bottomley SP, Wintrode PL. The Z mutation alters the global structural dynamics of α1-antitrypsin. Plos One. 9: e102617. PMID 25181470 DOI: 10.1371/journal.pone.0102617  0.56
2014 Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, et al. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. The Journal of Biological Chemistry. 289: 669-79. PMID 24275656 DOI: 10.1074/jbc.M113.523407  0.56
2013 Cheng J, Karri S, Grauffel C, Wang F, Reuter N, Roberts MF, Wintrode PL, Gershenson A. Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding? Biophysical Journal. 104: 185-95. PMID 23332071 DOI: 10.1016/j.bpj.2012.11.015  0.56
2012 Stocks BB, Sarkar A, Wintrode PL, Konermann L. Early hydrophobic collapse of α₁-antitrypsin facilitates formation of a metastable state: insights from oxidative labeling and mass spectrometry. Journal of Molecular Biology. 423: 789-99. PMID 22940366 DOI: 10.1016/j.jmb.2012.08.019  0.56
2012 Tsutsui Y, Dela Cruz R, Wintrode PL. Folding mechanism of the metastable serpin α1-antitrypsin. Proceedings of the National Academy of Sciences of the United States of America. 109: 4467-72. PMID 22392975 DOI: 10.1073/pnas.1109125109  0.56
2012 Cheng I, Mikita N, Fishovitz J, Frase H, Wintrode P, Lee I. Identification of a region in the N-terminus of Escherichia coli Lon that affects ATPase, substrate translocation and proteolytic activity. Journal of Molecular Biology. 418: 208-25. PMID 22387465 DOI: 10.1016/j.jmb.2012.02.039  0.56
2011 Tsutsui Y, Sarkar A, Wintrode PL. Probing serpin conformational change using mass spectrometry and related methods. Methods in Enzymology. 501: 325-50. PMID 22078541 DOI: 10.1016/B978-0-12-385950-1.00015-8  0.56
2011 Sarkar A, Zhou C, Meklemburg R, Wintrode PL. Local conformational flexibility provides a basis for facile polymer formation in human neuroserpin. Biophysical Journal. 101: 1758-65. PMID 21961602 DOI: 10.1016/j.bpj.2011.08.037  0.56
2011 Sarkar A, Wintrode PL. Effects of glycosylation on the stability and flexibility of a metastable protein: the human serpin α(1)-antitrypsin. International Journal of Mass Spectrometry. 302: 69-75. PMID 21765645 DOI: 10.1016/j.ijms.2010.08.003  0.56
2011 Seckler JM, Barkley MD, Wintrode PL. Allosteric suppression of HIV-1 reverse transcriptase structural dynamics upon inhibitor binding. Biophysical Journal. 100: 144-53. PMID 21190666 DOI: 10.1016/j.bpj.2010.11.004  0.56
2010 Braz VA, Barkley MD, Jockusch RA, Wintrode PL. Efavirenz binding site in HIV-1 reverse transcriptase monomers. Biochemistry. 49: 10565-73. PMID 21090588 DOI: 10.1021/bi101480z  0.56
2009 Sengupta T, Tsutsui Y, Wintrode PL. Local and global effects of a cavity filling mutation in a metastable serpin. Biochemistry. 48: 8233-40. PMID 19624115 DOI: 10.1021/bi900342d  0.56
2009 Seckler JM, Howard KJ, Barkley MD, Wintrode PL. Solution structural dynamics of HIV-1 reverse transcriptase heterodimer. Biochemistry. 48: 7646-55. PMID 19594135 DOI: 10.1021/bi900790x  0.56
2008 Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 47: 12409-19. PMID 18975915 DOI: 10.1021/bi8015444  0.56
2008 Tsutsui Y, Kuri B, Sengupta T, Wintrode PL. The structural basis of serpin polymerization studied by hydrogen/deuterium exchange and mass spectrometry. The Journal of Biological Chemistry. 283: 30804-11. PMID 18794298 DOI: 10.1074/jbc.M804048200  0.56
2008 Zheng X, Wintrode PL, Chance MR. Complementary structural mass spectrometry techniques reveal local dynamics in functionally important regions of a metastable serpin. Structure (London, England : 1993). 16: 38-51. PMID 18184582 DOI: 10.1016/j.str.2007.10.019  0.56
2007 Tsutsui Y, Wintrode PL. Hydrogen/deuterium exchange-mass spectrometry: a powerful tool for probing protein structure, dynamics and interactions. Current Medicinal Chemistry. 14: 2344-58. PMID 17896983 DOI: 10.2174/092986707781745596  0.56
2007 Tsutsui Y, Wintrode PL. Cooperative unfolding of a metastable serpin to a molten globule suggests a link between functional and folding energy landscapes. Journal of Molecular Biology. 371: 245-55. PMID 17568610 DOI: 10.1016/j.jmb.2007.05.039  0.56
2007 Lu X, Wintrode PL, Surewicz WK. Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange. Proceedings of the National Academy of Sciences of the United States of America. 104: 1510-5. PMID 17242357 DOI: 10.1073/pnas.0608447104  0.56
2006 Tsutsui Y, Liu L, Gershenson A, Wintrode PL. The conformational dynamics of a metastable serpin studied by hydrogen exchange and mass spectrometry. Biochemistry. 45: 6561-9. PMID 16716066 DOI: 10.1021/bi060431f  0.56
2005 Wintrode PL, Rojsajjakul T, Vadrevu R, Matthews CR, Smith DL. An obligatory intermediate controls the folding of the alpha-subunit of tryptophan synthase, a TIM barrel protein. Journal of Molecular Biology. 347: 911-9. PMID 15784252 DOI: 10.1016/j.jmb.2005.01.064  0.56
2003 Wintrode PL, Friedrich KL, Vierling E, Smith JB, Smith DL. Solution structure and dynamics of a heat shock protein assembly probed by hydrogen exchange and mass spectrometry. Biochemistry. 42: 10667-73. PMID 12962491 DOI: 10.1021/bi034117m  0.56
2003 Wintrode PL, Zhang D, Vaidehi N, Arnold FH, Goddard WA. Protein dynamics in a family of laboratory evolved thermophilic enzymes. Journal of Molecular Biology. 327: 745-57. PMID 12634066 DOI: 10.1016/S0022-2836(03)00147-5  0.56
2002 Wintrode PL, Smith JB, Basha E, Vierling E, Smith DL. Solution conformation and dynamics of a heat shock protein complex probed by hydrogen exchange/mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 129-130.  0.56
2001 Wintrode PL, Miyazaki K, Arnold FH. Patterns of adaptation in a laboratory evolved thermophilic enzyme. Biochimica Et Biophysica Acta. 1549: 1-8. PMID 11566363 DOI: 10.1016/S0167-4838(01)00226-6  0.56
2001 Arnold FH, Wintrode PL, Miyazaki K, Gershenson A. How enzymes adapt: lessons from directed evolution. Trends in Biochemical Sciences. 26: 100-6. PMID 11166567 DOI: 10.1016/S0968-0004(00)01755-2  0.56
2000 Wintrode PL, Arnold FH. Temperature adaptation of enzymes: lessons from laboratory evolution. Advances in Protein Chemistry. 55: 161-225. PMID 11050934  0.56
2000 Wintrode PL, Miyazaki K, Arnold FH. Cold adaptation of a mesophilic subtilisin-like protease by laboratory evolution Journal of Biological Chemistry. 275: 31635-31640. PMID 10906329  0.56
2000 Miyazaki K, Wintrode PL, Grayling RA, Rubingh DN, Arnold FH. Directed evolution study of temperature adaptation in a psychrophilic enzyme Journal of Molecular Biology. 297: 1015-1026. PMID 10736234 DOI: 10.1006/jmbi.2000.3612  0.56
1997 Wintrode PL, Privalov PL. Energetics of target peptide recognition by calmodulin: A calorimetric study Journal of Molecular Biology. 266: 1050-1062. PMID 9086281 DOI: 10.1006/jmbi.1996.0785  0.56
1995 Wintrode PL, Griko YV, Privalov PL. Structural energetics of barstar studied by differential scanning microcalorimetry Protein Science. 4: 1528-1534. PMID 8520478 DOI: 10.1002/pro.5560040810  0.56
1994 Wintrode PL, Makhatadze GI, Privalov PL. Thermodynamics of ubiquitin unfolding Proteins: Structure, Function and Genetics. 18: 246-253. PMID 8202465 DOI: 10.1002/prot.340180305  0.56
1994 Lawson TG, Gronros DL, Werner JA, Wey AC, DiGeorge AM, Lockhart JL, Wilson JW, Wintrode PL. The encephalomyocarditis virus 3C protease is a substrate for the ubiquitin-mediated proteolytic system Journal of Biological Chemistry. 269: 28429-28435. PMID 7961784  0.56
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