| Year |
Citation |
Score |
| 2023 |
Kaur U, Kihn KC, Ke H, Kuo W, Gierasch LM, Hebert DN, Wintrode PL, Deredge D, Gershenson A. The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control. Biorxiv : the Preprint Server For Biology. PMID 37163105 DOI: 10.1101/2023.04.24.537978 |
0.303 |
|
| 2022 |
Kihn K, Marchiori E, Spagnolli G, Boldrini A, Terruzzi L, Lawrence DA, Gershenson A, Faccioli P, Wintrode PL. Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin. The Journal of Biological Chemistry. 298: 102652. PMID 36444882 DOI: 10.1016/j.jbc.2022.102652 |
0.31 |
|
| 2021 |
Kihn KC, Wilson T, Smith AK, Bradshaw RT, Wintrode PL, Forrest LR, Wilks A, Deredge DJ. Modeling the native ensemble of PhuS using enhanced sampling MD and HDX-ensemble reweighting. Biophysical Journal. PMID 34767787 DOI: 10.1016/j.bpj.2021.11.010 |
0.32 |
|
| 2020 |
Klontz EH, Li C, Kihn K, Fields JK, Beckett D, Snyder GA, Wintrode PL, Deredge D, Wang LX, Sundberg EJ. Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation. Nature Communications. 11: 6204. PMID 33277506 DOI: 10.1038/s41467-020-20044-z |
0.31 |
|
| 2020 |
Orlandi C, Deredge D, Ray K, Gohain N, Tolbert W, DeVico AL, Wintrode P, Pazgier M, Lewis GK. Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding. Structure (London, England : 1993). PMID 32209433 DOI: 10.1016/J.Str.2020.03.001 |
0.314 |
|
| 2019 |
Gershenson A, Gosavi S, Faccioli P, Wintrode PL. Successes and challenges in simulating the folding of large proteins. The Journal of Biological Chemistry. PMID 31712314 DOI: 10.1074/Jbc.Rev119.006794 |
0.365 |
|
| 2019 |
Deredge D, Wintrode PL, Tulapurkar ME, Nagarsekar A, Zhang Y, Weber DJ, Shapiro P, Hasday JD. A temperature-dependent conformational shift in p38α MAP kinase substrate binding region associated with changes in substrate phosphorylation profile. The Journal of Biological Chemistry. PMID 31213525 DOI: 10.1074/Jbc.Ra119.007525 |
0.359 |
|
| 2019 |
Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable JD, ... ... Wintrode PL, et al. Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab fragment of NISTmAb. Analytical Chemistry. PMID 31045344 DOI: 10.1021/Acs.Analchem.9B01100 |
0.304 |
|
| 2019 |
Klontz EH, Trastoy B, Deredge D, Fields JK, Li C, Orwenyo J, Marina A, Beadenkopf R, Günther S, Flores J, Wintrode PL, Wang LX, Guerin ME, Sundberg EJ. Molecular Basis of Broad Spectrum -Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. Acs Central Science. 5: 524-538. PMID 30937380 DOI: 10.2210/Pdb6E58/Pdb |
0.355 |
|
| 2019 |
Taraban MB, Deredge DJ, Smith ME, Briggs KT, Li Y, Jiang ZX, Wintrode P, Yu YB. Monitoring Dendrimer Conformational Transition using F and H O NMR. Magnetic Resonance in Chemistry : Mrc. PMID 30746779 DOI: 10.1002/Mrc.4849 |
0.308 |
|
| 2019 |
Deredge DJ, White M, Tran A, Wintrode P, Garcin E. Binding Interface of Gapdh to the Au Rich Elements from TNF-Alpha mRNA Revealed by Hydrogen Deuterium Exchange Coupled with Mass Spectrometry Biophysical Journal. 116: 484a. DOI: 10.1016/J.Bpj.2018.11.2613 |
0.317 |
|
| 2018 |
Wang F, Orioli S, Ianeselli A, Spagnolli G, A Beccara S, Gershenson A, Faccioli P, Wintrode PL. All-Atom Simulations Reveal How Single-Point Mutations Promote Serpin Misfolding. Biophysical Journal. 114: 2083-2094. PMID 29742402 DOI: 10.1016/J.Bpj.2018.03.027 |
0.302 |
|
| 2018 |
Bonsor DA, Zhao Q, Schmidinger B, Weiss E, Wang J, Deredge D, Beadenkopf R, Dow B, Fischer W, Beckett D, Wintrode PL, Haas R, Sundberg EJ. The adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. The Embo Journal. PMID 29724755 DOI: 10.15252/Embj.201798664 |
0.33 |
|
| 2018 |
Bradshaw RT, Nagarajan A, Adhikary S, Deredge DJ, Wintrode PL, Singh SK, Forrest LR. Neurotransmitter Transporter Conformational Dynamics using HDX-MS and Molecular Dynamics Simulation Biophysical Journal. 114: 207a. DOI: 10.1016/J.Bpj.2017.11.1161 |
0.309 |
|
| 2017 |
Klontz EH, Tomich AD, Günther S, Lemkul JA, Deredge D, Silverstein Z, Shaw JF, McElheny C, Doi Y, Wintrode P, MacKerell AD, Sluis-Cremer N, Sundberg EJ. Structure and dynamics of FosA-mediated fosfomycin resistance in Klebsiella pneumoniae and Escherichia coli. Antimicrobial Agents and Chemotherapy. PMID 28874374 DOI: 10.1128/Aac.01572-17 |
0.354 |
|
| 2017 |
Deredge DJ, Huang W, Hui C, Matsumura H, Yue Z, Moënne-Loccoz P, Shen J, Wintrode PL, Wilks A. Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28289188 DOI: 10.1073/Pnas.1606931114 |
0.426 |
|
| 2017 |
Adhikary S, Deredge DJ, Nagarajan A, Forrest LR, Wintrode PL, Singh SK. Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223522 DOI: 10.1073/Pnas.1613293114 |
0.384 |
|
| 2017 |
Kuo W, Kaur U, Deredge D, Kilcoyne CJ, Clerico EM, Wintrode PL, Gierasch LM, Gershenson A. Folding in Pieces Biophysical Journal. 112: 167a. DOI: 10.1016/J.Bpj.2016.11.921 |
0.43 |
|
| 2016 |
Postel S, Deredge D, Bonsor DA, Yu X, Diederichs K, Helmsing S, Vromen A, Friedler A, Hust M, Egelman EH, Beckett D, Wintrode PL, Sundberg EJ. Bacterial flagellar capping proteins adopt diverse oligomeric states. Elife. 5. PMID 27664419 DOI: 10.7554/Elife.18857 |
0.337 |
|
| 2016 |
Wang F, Cazzolli G, Wintrode P, Faccioli P. The Folding Mechanism of Proteins Im7 and Im9: Insight from All-Atom Simulations in Implicit and Explicit Solvent. The Journal of Physical Chemistry. B. PMID 27532482 DOI: 10.1021/Acs.Jpcb.6B05819 |
0.364 |
|
| 2016 |
Tsutsui Y, Deredge D, Wintrode PL, Hays FA. Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy. Scientific Reports. 6: 30832. PMID 27480221 DOI: 10.1038/Srep30832 |
0.381 |
|
| 2016 |
Deredge D, Li J, Johnson KA, Wintrode PL. Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase. The Journal of Biological Chemistry. PMID 27006396 DOI: 10.1074/Jbc.M115.708370 |
0.366 |
|
| 2016 |
Wang F, Ke H, Beccara Sa, Gershenson A, Faccioli P, Wintrode P. Folding Mechanism of a Metastable Serpin at Atomic Resolution Biophysical Journal. 110: 369a. DOI: 10.1016/J.Bpj.2015.11.1988 |
0.392 |
|
| 2016 |
Deredge DJ, Huang W, Hui C, Moenne-Loccoz P, Wilks A, Wintrode P. Ligand Induced Allostery in Pseudomonas Aeruginosa Cytoplasmic Heme Binding Protein (Phus) Drives the Protein-Protein Interaction with Heme Oxygenase Biophysical Journal. 110: 221a. DOI: 10.1016/J.Bpj.2015.11.1225 |
0.404 |
|
| 2015 |
Lupton CJ, Steer DL, Wintrode PL, Bottomley SP, Hughes VA, Ellisdon AM. Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease. The Journal of Biological Chemistry. 290: 24190-200. PMID 26260925 DOI: 10.1074/Jbc.M115.659532 |
0.333 |
|
| 2015 |
White MR, Khan MM, Deredge D, Ross CR, Quintyn R, Zucconi BE, Wysocki VH, Wintrode PL, Wilson GM, Garcin ED. A dimer interface mutation in glyceraldehyde-3-phosphate dehydrogenase regulates its binding to AU-rich RNA. The Journal of Biological Chemistry. 290: 1770-85. PMID 25451934 DOI: 10.1074/Jbc.M114.618165 |
0.386 |
|
| 2015 |
Deredge DJ, Johnson K, Wintrode P. Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase Biophysical Journal. 108: 529a. DOI: 10.1016/J.Bpj.2014.11.2900 |
0.372 |
|
| 2015 |
Wang F, Cazzolli G, Wintrode P, Faccioli P. Folding Mechanism of Proteins IM7 and IM9, from Computer Simulations in a Realistic Atomistic Force Field Biophysical Journal. 108: 519a. DOI: 10.1016/J.Bpj.2014.11.2844 |
0.354 |
|
| 2015 |
White M, Khan M, Deredge D, Ross C, Quintyn R, Zucconi B, Wysocki V, Wintrode P, Wilson G, Garcin E. Dynamics of Glyceraldehyde-3-Phosphate Dehydrogenase Interfacial Regions Affect Binding to AU-Rich RNA Biophysical Journal. 108: 401a. DOI: 10.1016/J.Bpj.2014.11.2198 |
0.384 |
|
| 2015 |
Wintrode P, Faccioli P, Beccara Sa, Gershenson A, Cazzolli G, Wang F. Simulating the Serpin Latency Transition at Atomic Resolution Biophysical Journal. 108: 317a. DOI: 10.1016/J.Bpj.2014.11.1722 |
0.369 |
|
| 2014 |
Cazzolli G, Wang F, a Beccara S, Gershenson A, Faccioli P, Wintrode PL. Serpin latency transition at atomic resolution. Proceedings of the National Academy of Sciences of the United States of America. 111: 15414-9. PMID 25313058 DOI: 10.1073/Pnas.1407528111 |
0.324 |
|
| 2014 |
Hughes VA, Meklemburg R, Bottomley SP, Wintrode PL. The Z mutation alters the global structural dynamics of α1-antitrypsin. Plos One. 9: e102617. PMID 25181470 DOI: 10.1371/Journal.Pone.0102617 |
0.37 |
|
| 2014 |
Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, et al. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. The Journal of Biological Chemistry. 289: 669-79. PMID 24275656 DOI: 10.1074/Jbc.M113.523407 |
0.373 |
|
| 2013 |
Cheng J, Karri S, Grauffel C, Wang F, Reuter N, Roberts MF, Wintrode PL, Gershenson A. Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding? Biophysical Journal. 104: 185-95. PMID 23332071 DOI: 10.1016/J.Bpj.2012.11.015 |
0.372 |
|
| 2013 |
Grauffel C, He T, Yang B, Wintrode PL, Gershenson A, Roberts MF, Reuter N. Cation-PI Interactions as Specific Anchors for B. Thurigiensis Phosphoinositol-Specific Phospholipase-C Binding to Phosphatidylcholine Bilayer Biophysical Journal. 104: 536a. DOI: 10.1016/J.Bpj.2012.11.2969 |
0.333 |
|
| 2012 |
Stocks BB, Sarkar A, Wintrode PL, Konermann L. Early hydrophobic collapse of α₁-antitrypsin facilitates formation of a metastable state: insights from oxidative labeling and mass spectrometry. Journal of Molecular Biology. 423: 789-99. PMID 22940366 DOI: 10.1016/J.Jmb.2012.08.019 |
0.403 |
|
| 2012 |
Tsutsui Y, Dela Cruz R, Wintrode PL. Folding mechanism of the metastable serpin α1-antitrypsin. Proceedings of the National Academy of Sciences of the United States of America. 109: 4467-72. PMID 22392975 DOI: 10.1073/Pnas.1109125109 |
0.354 |
|
| 2012 |
Cheng I, Mikita N, Fishovitz J, Frase H, Wintrode P, Lee I. Identification of a region in the N-terminus of Escherichia coli Lon that affects ATPase, substrate translocation and proteolytic activity. Journal of Molecular Biology. 418: 208-25. PMID 22387465 DOI: 10.1016/J.Jmb.2012.02.039 |
0.393 |
|
| 2012 |
Grauffel C, He T, Yang B, Guo S, Wintrode PL, Gershenson A, Roberts MF, Reuter N. Anchoring of PI-PLC to DMPC Bilayers Involves Specific Cation-PI Interactions Biophysical Journal. 102: 78a-79a. DOI: 10.1016/J.Bpj.2011.11.455 |
0.355 |
|
| 2012 |
Deredge D, Venencia C, Howard K, Barkley MD, Wintrode PL. Conformational Flexibility Mediates Resistance of HIV-1 Reverse Transcriptase to Nonucleoside Inhibitors Biophysical Journal. 102: 52a. DOI: 10.1016/J.Bpj.2011.11.314 |
0.412 |
|
| 2012 |
Seckler JM, Trewhella J, Barkley MD, Wintrode PL. HIV-1 Reverse Transcriptase Monomers Adopt Multiple Conformations in Solution Biophysical Journal. 102: 46a-47a. DOI: 10.1016/J.Bpj.2011.11.284 |
0.402 |
|
| 2011 |
Tsutsui Y, Sarkar A, Wintrode PL. Probing serpin conformational change using mass spectrometry and related methods. Methods in Enzymology. 501: 325-50. PMID 22078541 DOI: 10.1016/B978-0-12-385950-1.00015-8 |
0.365 |
|
| 2011 |
Sarkar A, Zhou C, Meklemburg R, Wintrode PL. Local conformational flexibility provides a basis for facile polymer formation in human neuroserpin. Biophysical Journal. 101: 1758-65. PMID 21961602 DOI: 10.1016/J.Bpj.2011.08.037 |
0.352 |
|
| 2011 |
Sarkar A, Wintrode PL. Effects of glycosylation on the stability and flexibility of a metastable protein: the human serpin α(1)-antitrypsin. International Journal of Mass Spectrometry. 302: 69-75. PMID 21765645 DOI: 10.1016/J.Ijms.2010.08.003 |
0.383 |
|
| 2011 |
Seckler JM, Barkley MD, Wintrode PL. Allosteric suppression of HIV-1 reverse transcriptase structural dynamics upon inhibitor binding. Biophysical Journal. 100: 144-53. PMID 21190666 DOI: 10.1016/J.Bpj.2010.11.004 |
0.659 |
|
| 2011 |
Zhou C, Sarkar A, Wintrode PL. Native State Dynamics of Human Neuroserpin Investigated with Hydrogen/Deuterium Exchange and Molecular Dynamics Simulations Biophysical Journal. 100: 50a. DOI: 10.1016/J.Bpj.2010.12.469 |
0.411 |
|
| 2011 |
Sarkar A, Zhou C, Wintrode PL. Is the Serpin Folding Mechanism Conserved? The Folding Pathways of Human Alpha-1 Antitrypsin and Neuroserpin Biophysical Journal. 100: 515a. DOI: 10.1016/J.Bpj.2010.12.3016 |
0.407 |
|
| 2011 |
Deredge DJ, Howard KJ, Seckler JM, Barkley MD, Wintrode PL. Molecular Origins of HIV-1 reverse Transcriptase Resistance to Efavirenz Biophysical Journal. 100: 227a. DOI: 10.1016/J.Bpj.2010.12.1455 |
0.408 |
|
| 2010 |
Braz VA, Barkley MD, Jockusch RA, Wintrode PL. Efavirenz binding site in HIV-1 reverse transcriptase monomers. Biochemistry. 49: 10565-73. PMID 21090588 DOI: 10.1021/Bi101480Z |
0.41 |
|
| 2009 |
Sengupta T, Tsutsui Y, Wintrode PL. Local and global effects of a cavity filling mutation in a metastable serpin. Biochemistry. 48: 8233-40. PMID 19624115 DOI: 10.1021/Bi900342D |
0.421 |
|
| 2009 |
Seckler JM, Howard KJ, Barkley MD, Wintrode PL. Solution structural dynamics of HIV-1 reverse transcriptase heterodimer. Biochemistry. 48: 7646-55. PMID 19594135 DOI: 10.1021/Bi900790X |
0.642 |
|
| 2009 |
Shi X, Roberts MF, Meklemburg R, Wintrode PL. H/D Exchange Provides Insights Into The Orientation Of Bacillus Thuringiensis Pi-phospholipase C Binding To Mixed Component Vesicles Biophysical Journal. 96: 612a. DOI: 10.1016/J.Bpj.2008.12.3235 |
0.4 |
|
| 2009 |
Sengupta T, Wintrode PL. Folding Mechanism Of The Z Mutant Of Human Antitrypsin Studied By H/D Exchange Biophysical Journal. 96: 81a. DOI: 10.1016/J.Bpj.2008.12.322 |
0.43 |
|
| 2009 |
Boucher L, de la Cruz R, Bock S, Wintrode PL. Conformational Dynamics of Antithrombin III With its Allosteric Activator Heparin Biophysical Journal. 96: 69a. DOI: 10.1016/J.Bpj.2008.12.258 |
0.446 |
|
| 2009 |
Braz VA, Wintrode PL, Barkley MD. Structural Changes in Monomeric HIV-RT Upon Binding the NNRTI Efavirenz Biophysical Journal. 96: 446a. DOI: 10.1016/J.Bpj.2008.12.2291 |
0.357 |
|
| 2008 |
Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 47: 12409-19. PMID 18975915 DOI: 10.1021/Bi8015444 |
0.36 |
|
| 2008 |
Tsutsui Y, Kuri B, Sengupta T, Wintrode PL. The structural basis of serpin polymerization studied by hydrogen/deuterium exchange and mass spectrometry. The Journal of Biological Chemistry. 283: 30804-11. PMID 18794298 DOI: 10.1074/Jbc.M804048200 |
0.361 |
|
| 2008 |
Zheng X, Wintrode PL, Chance MR. Complementary structural mass spectrometry techniques reveal local dynamics in functionally important regions of a metastable serpin. Structure (London, England : 1993). 16: 38-51. PMID 18184582 DOI: 10.1016/J.Str.2007.10.019 |
0.392 |
|
| 2007 |
Tsutsui Y, Wintrode PL. Hydrogen/deuterium exchange-mass spectrometry: a powerful tool for probing protein structure, dynamics and interactions. Current Medicinal Chemistry. 14: 2344-58. PMID 17896983 DOI: 10.2174/092986707781745596 |
0.3 |
|
| 2007 |
Tsutsui Y, Wintrode PL. Cooperative unfolding of a metastable serpin to a molten globule suggests a link between functional and folding energy landscapes. Journal of Molecular Biology. 371: 245-55. PMID 17568610 DOI: 10.1016/J.Jmb.2007.05.039 |
0.375 |
|
| 2007 |
Lu X, Wintrode PL, Surewicz WK. Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange. Proceedings of the National Academy of Sciences of the United States of America. 104: 1510-5. PMID 17242357 DOI: 10.1073/Pnas.0608447104 |
0.399 |
|
| 2006 |
Tsutsui Y, Liu L, Gershenson A, Wintrode PL. The conformational dynamics of a metastable serpin studied by hydrogen exchange and mass spectrometry. Biochemistry. 45: 6561-9. PMID 16716066 DOI: 10.1021/Bi060431F |
0.432 |
|
| 2005 |
Wintrode PL, Rojsajjakul T, Vadrevu R, Matthews CR, Smith DL. An obligatory intermediate controls the folding of the alpha-subunit of tryptophan synthase, a TIM barrel protein. Journal of Molecular Biology. 347: 911-9. PMID 15784252 DOI: 10.1016/J.Jmb.2005.01.064 |
0.401 |
|
| 2003 |
Wintrode PL, Zhang D, Vaidehi N, Arnold FH, Goddard WA. Protein dynamics in a family of laboratory evolved thermophilic enzymes. Journal of Molecular Biology. 327: 745-57. PMID 12634066 DOI: 10.1016/S0022-2836(03)00147-5 |
0.388 |
|
| 2001 |
Wintrode PL, Miyazaki K, Arnold FH. Patterns of adaptation in a laboratory evolved thermophilic enzyme. Biochimica Et Biophysica Acta. 1549: 1-8. PMID 11566363 DOI: 10.1016/S0167-4838(01)00226-6 |
0.3 |
|
| 2000 |
Wintrode PL, Arnold FH. Temperature adaptation of enzymes: lessons from laboratory evolution. Advances in Protein Chemistry. 55: 161-225. PMID 11050934 DOI: 10.1016/S0065-3233(01)55004-4 |
0.33 |
|
| 2000 |
Wintrode PL, Miyazaki K, Arnold FH. Cold adaptation of a mesophilic subtilisin-like protease by laboratory evolution Journal of Biological Chemistry. 275: 31635-31640. PMID 10906329 DOI: 10.1074/Jbc.M004503200 |
0.304 |
|
| 2000 |
Miyazaki K, Wintrode PL, Grayling RA, Rubingh DN, Arnold FH. Directed evolution study of temperature adaptation in a psychrophilic enzyme Journal of Molecular Biology. 297: 1015-1026. PMID 10736234 DOI: 10.1006/Jmbi.2000.3612 |
0.307 |
|
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