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Brigita Urbanc - Publications

Affiliations: 
Physics Drexel University, Philadelphia, PA, United States 
Area:
Molecular Physics, Genetics, General Biophysics
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Andrews B, Ruggiero T, Urbanc B. How do salt and lipids affect conformational dynamics of Aβ42 monomers in water? Physical Chemistry Chemical Physics : Pccp. PMID 36602150 DOI: 10.1039/d2cp05044g  0.32
2021 Urbanc B. Cross-Linked Amyloid β-Protein Oligomers: A Missing Link in Alzheimer's Disease Pathology? The Journal of Physical Chemistry. B. 125: 1307-1316. PMID 33440940 DOI: 10.1021/acs.jpcb.0c07716  0.363
2019 Zhang S, Schweitzer-Stenner R, Urbanc B. Do Molecular Dynamics Force Fields Capture Conformational Dynamics of Alanine in Water? Journal of Chemical Theory and Computation. PMID 31751129 DOI: 10.1021/Acs.Jctc.9B00588  0.335
2019 Long K, Williams TL, Urbanc B. Insulin Inhibits Aβ42 Aggregation and Prevents Aβ42-Induced Membrane Disruption. Biochemistry. PMID 31642314 DOI: 10.1021/Acs.Biochem.9B00696  0.378
2019 Zhang S, Fox DM, Urbanc B. Elucidating the Role of Hydroxylated Phenylalanine in Formation and Structure of Cross-Linked Aβ Oligomers. The Journal of Physical Chemistry. B. PMID 30642171 DOI: 10.1021/Acs.Jpcb.8B12120  0.422
2019 Long K, Williams TL, Urbanc B. In Vitro Study of the Effect of Insulin on Amyloid β-Protein Assembly and Toxicity Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2472  0.37
2017 Voelker MJ, Barz B, Urbanc B. Fully-Atomistic Aβ40 and Aβ42 Oligomers in Water: Observation of Pore-Like Conformations. Journal of Chemical Theory and Computation. PMID 28727426 DOI: 10.1021/Acs.Jctc.7B00495  0.463
2017 Zhang S, Fox DM, Urbanc B. Insights into Formation and Structure of Aβ Oligomers Cross-Linked via Tyrosines. The Journal of Physical Chemistry. B. PMID 28482661 DOI: 10.1021/Acs.Jpcb.7B02495  0.457
2017 Urbanc B. Flexible N-Termini of Amyloid β-Protein Oligomers: A Link between Structure and Activity? Israel Journal of Chemistry. 57: 651-664. DOI: 10.1002/Ijch.201600097  0.474
2016 žganec M, Kruczek N, Urbanc B. Amino acid substitutions [K16A] and [K28A] distinctly affect amyloid β-protein oligomerization Journal of Biological Physics. 42: 453-476. DOI: 10.1007/S10867-016-9417-4  0.339
2015 Williams TL, Serpell LC, Urbanc B. Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP). Biochimica Et Biophysica Acta. PMID 26699836 DOI: 10.1016/J.Bbapap.2015.12.001  0.471
2015 Williams TL, Urbanc B, Marshall KE, Vadukul DM, Jenkins AT, Serpell LC. Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation. Febs Letters. PMID 26450778 DOI: 10.1016/J.Febslet.2015.09.027  0.379
2015 Meral D, Toal S, Schweitzer-Stenner R, Urbanc B. Water-Centered Interpretation of Intrinsic pPII Propensities of Amino Acid Residues: In Vitro-Driven Molecular Dynamics Study. The Journal of Physical Chemistry. B. 119: 13237-51. PMID 26418575 DOI: 10.1021/Acs.Jpcb.5B06281  0.345
2015 Meral D, Urbanc B. Erratum to “Discrete Molecular Dynamics Study of Oligomer Formation by N-Terminally Truncated Amyloid β-Protein” [J. Mol. Biol. 425 (2013) 2260–2275] Journal of Molecular Biology. 427: 2726-2729. DOI: 10.1016/J.Jmb.2015.06.015  0.403
2015 Meral D, Urbanc B. DMD4B-HYDRA: Toward a Novel Discrete Molecular Dynamics Protein Model Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.865  0.379
2015 Voelker MJ, Urbanc B, Betnel M. A Computational Study of Amyloid β-Protein Assembly in Crowded Environments Biophysical Journal. 108: 5-5. DOI: 10.1016/J.Bpj.2014.11.2878  0.507
2015 Mawhinney MT, Urbanc B. Elucidating the Role of Oligomers in Insulin Aggregation using Biophysical Methods Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2121  0.379
2014 Barz B, Urbanc B. Minimal model of self-assembly: emergence of diversity and complexity. The Journal of Physical Chemistry. B. 118: 3761-70. PMID 24571643 DOI: 10.1021/Jp412819J  0.358
2013 Meral D, Urbanc B. Discrete molecular dynamics study of oligomer formation by N-terminally truncated amyloid β-protein Journal of Molecular Biology. 425: 2260-2275. PMID 23500806 DOI: 10.1016/J.Jmb.2013.03.010  0.49
2013 Toal S, Meral D, Verbaro D, Urbanc B, Schweitzer-Stenner R. pH-Independence of trialanine and the effects of termini blocking in short peptides: a combined vibrational, NMR, UVCD, and molecular dynamics study. The Journal of Physical Chemistry. B. 117: 3689-706. PMID 23448349 DOI: 10.1021/Jp310466B  0.337
2013 Fox D, Urbanc B. The Role of Di-Tyrosine Bonding in Amyloid Beta-Protein Assembly Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2180  0.441
2012 Shea JE, Urbanc B. Insights into Aβ aggregation: a molecular dynamics perspective. Current Topics in Medicinal Chemistry. 12: 2596-610. PMID 23339310 DOI: 10.2174/1568026611212220012  0.468
2012 Cruz L, Rao JS, Teplow DB, Urbanc B. Dynamics of metastable β-hairpin structures in the folding nucleus of amyloid β-protein. The Journal of Physical Chemistry. B. 116: 6311-25. PMID 22587454 DOI: 10.1021/Jp301619V  0.415
2012 Barz B, Urbanc B. Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics study. Plos One. 7: e34345. PMID 22509291 DOI: 10.1371/Journal.Pone.0034345  0.505
2012 Verbaro D, Meral D, Urbanc B, Rybka K, Schwalbe H, Schweitzer-Stenner R. Is the Amino Acid Dipeptide a Suitable Model for Investigating Structural Preferences in the Unfolded State? Biophysical Journal. 102: 253a. DOI: 10.1016/J.Bpj.2011.11.1394  0.333
2011 Williams TL, Johnson BR, Urbanc B, Jenkins AT, Connell SD, Serpell LC. Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes. The Biochemical Journal. 439: 67-77. PMID 21702743 DOI: 10.1042/Bj20110750  0.436
2011 Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G. Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. Journal of Molecular Biology. 410: 316-28. PMID 21621545 DOI: 10.1016/J.Jmb.2011.05.021  0.403
2011 Lam A, Teplow D, Stanley H, Urbanc B. Erratum: Effects of the arctic (E22→G) mutation on amyloid β-protein folding: Discrete molecular dynamics study (Journal of the American Chemical Society (2008) 130 (17413-17422) DOI: 10.1021/ja804984h) - eScholarship Journal of the American Chemical Society. 133: 2789. DOI: 10.1021/Ja111314D  0.471
2011 Urbanc B, Barz B, Betnel M, Cruz L, Bitan G, Teplow DB. Structural Basis for Amyloid β-Protein Toxicity Inhibition: A Multiscale Computational Study Biophysical Journal. 100: 390a. DOI: 10.1016/J.Bpj.2010.12.2317  0.483
2011 Barz B, Kepics C, Ferrone FA, Urbanc B. Minimalistic Approach to Protein Assembly Modelling/Application to the Sickle Cell Hemoglobin Polymerization Biophysical Journal. 100: 389a. DOI: 10.1016/J.Bpj.2010.12.2314  0.381
2010 Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 49: 6358-64. PMID 20568734 DOI: 10.1021/Bi100773G  0.419
2010 Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB. Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study. Journal of the American Chemical Society. 132: 4266-80. PMID 20218566 DOI: 10.1021/Ja9096303  0.457
2010 Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 49: 1259-67. PMID 20050679 DOI: 10.1021/Bi902075H  0.451
2009 Al-Rawi AN, Urbanc B, Ganguly D, Rahman TS, Chen J, Tomich J. Molecular Dynamics Simulations of a Single 11-Residue Beta-Sheet Adhesive and its Assembly Biophysical Journal. 96: 75a-76a. DOI: 10.1016/J.Bpj.2008.12.290  0.382
2009 Urbanc B, Bitan G, Cruz L, Lam A, Teplow D. Computational Study of Assembly and Toxicity Inhibition of Amyloid Beta-Protein and Its Arctic Mutant Biophysical Journal. 96: 219a. DOI: 10.1016/J.Bpj.2008.12.1913  0.435
2008 Lam AR, Teplow DB, Stanley HE, Urbanc B. Effects of the Arctic (E22-->G) mutation on amyloid beta-protein folding: discrete molecular dynamics study. Journal of the American Chemical Society. 130: 17413-22. PMID 19053400 DOI: 10.1021/Ja804984H  0.427
2008 Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 14175-80. PMID 18779585 DOI: 10.1073/Pnas.0807163105  0.416
2007 Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, Stanley HE. Role of electrostatic interactions in amyloid beta-protein (A beta) oligomer formation: a discrete molecular dynamics study. Biophysical Journal. 92: 4064-77. PMID 17307823 DOI: 10.1529/Biophysj.106.097766  0.319
2006 Urbanc B, Cruz L, Teplow DB, Stanley HE. Computer simulations of Alzheimer's amyloid beta-protein folding and assembly. Current Alzheimer Research. 3: 493-504. PMID 17168648 DOI: 10.2174/156720506779025170  0.45
2006 Urbanc B, Borreguero JM, Cruz L, Stanley HE. Ab initio discrete molecular dynamics approach to protein folding and aggregation. Methods in Enzymology. 412: 314-38. PMID 17046666 DOI: 10.1016/S0076-6879(06)12019-4  0.423
2006 Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Accounts of Chemical Research. 39: 635-45. PMID 16981680 DOI: 10.1021/Ar050063S  0.417
2005 Cruz L, Urbanc B, Borreguero JM, Lazo ND, Teplow DB, Stanley HE. Solvent and mutation effects on the nucleation of amyloid beta-protein folding. Proceedings of the National Academy of Sciences of the United States of America. 102: 18258-63. PMID 16339896 DOI: 10.1073/Pnas.0509276102  0.474
2005 Borreguero JM, Urbanc B, Lazo ND, Buldyrev SV, Teplow DB, Stanley HE. Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico. Proceedings of the National Academy of Sciences of the United States of America. 102: 6015-20. PMID 15837927 DOI: 10.1073/Pnas.0502006102  0.49
2004 Urbanc B, Cruz L, Yun S, Buldyrev SV, Bitan G, Teplow DB, Stanley HE. In silico study of amyloid beta-protein folding and oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 101: 17345-50. PMID 15583128 DOI: 10.1073/Pnas.0408153101  0.467
2004 Urbanc B, Cruz L, Ding F, Sammond D, Khare S, Buldyrev SV, Stanley HE, Dokholyan NV. Molecular dynamics simulation of amyloid beta dimer formation. Biophysical Journal. 87: 2310-21. PMID 15454432 DOI: 10.1529/Biophysj.104.040980  0.458
2004 Peng S, Ding F, Urbanc B, Buldyrev SV, Cruz L, Stanley HE, Dokholyan NV. Discrete molecular dynamics simulations of peptide aggregation. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 69: 041908. PMID 15169044 DOI: 10.1103/Physreve.69.041908  0.397
2002 Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 13990-5. PMID 12374847 DOI: 10.1073/Pnas.222433299  0.436
2001 Le R, Cruz L, Urbanc B, Knowles RB, Hsiao-Ashe K, Duff K, Irizarry MC, Stanley HE, Hyman BT. Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. Journal of Neuropathology and Experimental Neurology. 60: 753-8. PMID 11487049 DOI: 10.1093/Jnen/60.8.753  0.413
2000 Buldyrev SV, Cruz L, Gomez-Isla T, Gomez-Tortosa E, Havlin S, Le R, Stanley HE, Urbanc B, Hyman BT. Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias Proceedings of the National Academy of Sciences of the United States of America. 97: 5039-5043. PMID 10805766 DOI: 10.1073/Pnas.060009897  0.333
1999 Urbanc B, Cruz L, Buldyrev SV, Havlin S, Hyman BT, Stanley HE. Dynamic feedback in an aggregation-disaggregation model Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 60: 2120-2126. PMID 11970004 DOI: 10.1103/Physreve.60.2120  0.328
1999 Knowles RB, Wyart C, Buldyrev SV, Cruz L, Urbanc B, Hasselmo ME, Stanley HE, Hyman BT. Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 96: 5274-9. PMID 10220456 DOI: 10.1073/pnas.96.9.5274  0.304
1999 Urbanc B, Cruz L, Buldyrev SV, Havlin S, Irizarry MC, Stanley HE, Hyman BT. Dynamics of plaque formation in Alzheimer's disease Biophysical Journal. 76: 1330-1334. PMID 10049316 DOI: 10.1016/S0006-3495(99)77295-4  0.395
1999 Hyman BT, Knowles RB, Wyart C, Buldyrev SV, Cruz L, Urbanc B, Hasselmo ME, Stanley HE. PLAQUE-INDUCED NEURITE ABNORMALITIES Journal of Neuropathology and Experimental Neurology. 58: 557. DOI: 10.1097/00005072-199905000-00204  0.307
1998 Stanley H, Buldyrev SV, Cruz L, Gomez-Isla T, Havlin S, Hyman BT, Knowles R, Urbanc B, Wyart C. Statistical physics and Alzheimer’s disease Physica a: Statistical Mechanics and Its Applications. 249: 460-471. DOI: 10.1016/S0378-4371(97)00548-7  0.337
1997 Cruz L, Urbanc B, Buldyrev SV, Christie R, Gómez-Isla T, Havlin S, McNamara M, Stanley HE, Hyman BT. Aggregation and disaggregation of senile plaques in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 7612-6. PMID 9207140 DOI: 10.1073/Pnas.94.14.7612  0.428
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