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Frederick Khachik - Publications

Affiliations: 
Chemistry University of Maryland, College Park, College Park, MD 
Area:
Organic Chemistry, Analytical Chemistry
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Khachik F. Transformation of naturally occurring (3R,3'R,6'R)-lutein and its fatty acid esters to (3R)-β-cryptoxanthin and (3R,6'R)-α-cryptoxanthin. Archives of Biochemistry and Biophysics. PMID 29990480 DOI: 10.1016/J.Abb.2018.06.012  0.412
2014 Crawford K, Mazzola E, Khachik F. Total synthesis of 1,2,5,6-tetrahydro-2,6-cyclo-γ-carotene-1,5-diol, an oxidation product of γ-carotene Synthesis (Germany). 46: 635-645. DOI: 10.1055/S-0033-1340555  0.348
2012 Khachik F. Partial synthesis of serum carotenoids and their metabolites. Acta Biochimica Polonica. 59: 75-8. PMID 22428147 DOI: 10.18388/Abp.2012_2175  0.397
2012 Khachik F. Synthesis of (3 R,3 R)-zeaxanthin and its meso -stereoisomer from (3 R,3 R,6 R)-lutein via (3 R)-3,4-anhydrolutein Synthesis. 44: 453-459. DOI: 10.1055/S-0031-1289662  0.321
2011 Khachik F, Chang AN. Synthesis of (3S)- and (3R)-3-hydroxy-β-ionone and their transformation into (3S)- and (3R)-β- cryptoxanthin Synthesis. 509-516. DOI: 10.1055/S-0030-1258382  0.401
2011 Khachik F. Industrially viable processes for synthesis of biologically active hydroxycarotenoids commonly found in fruits and vegetables Journal of Food Composition and Analysis. 24: 826-829. DOI: 10.1016/j.jfca.2011.02.005  0.322
2009 Khachik F, Chang AN. Total synthesis of (3R,3'R,6'R)-lutein and its stereoisomers. The Journal of Organic Chemistry. 74: 3875-85. PMID 19391613 DOI: 10.1021/Jo900432R  0.373
2007 Sahin K, Ozercan R, Onderci M, Sahin N, Khachik F, Seren S, Kucuk O. Dietary tomato powder supplementation in the prevention of leiomyoma of the oviduct in the Japanese quail. Nutrition and Cancer. 59: 70-5. PMID 17927504 DOI: 10.1080/01635580701365076  0.308
2007 Khachik F, Chang AN, Gana A, Mazzola E. Partial synthesis of (3R,6'R)-alpha-cryptoxanthin and (3R)-beta-cryptoxanthin from (3R,3'R,6'R)-lutein. Journal of Natural Products. 70: 220-6. PMID 17266370 DOI: 10.1021/Np060575V  0.34
2006 Khachik F, London E, de Moura FF, Johnson M, Steidl S, Detolla L, Shipley S, Sanchez R, Chen XQ, Flaws J, Lutty G, McLeod S, Fowler B. Chronic ingestion of (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the female rhesus macaque. Investigative Ophthalmology & Visual Science. 47: 5476-86. PMID 17122139 DOI: 10.1167/Iovs.06-0194  0.344
2006 Khachik F. Distribution and metabolism of dietary carotenoids in humans as a criterion for development of nutritional supplements Pure and Applied Chemistry. 78: 1551-1557. DOI: 10.1351/Pac200678081551  0.361
2004 Sahin K, Ozercan R, Onderci M, Sahin N, Gursu MF, Khachik F, Sarkar FH, Munkarah A, Ali-Fehmi R, Kmak D, Kucuk O. Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail. Nutrition and Cancer. 50: 181-9. PMID 15623465 DOI: 10.1207/S15327914Nc5002_8  0.303
2003 Humphries JM, Khachik F. Distribution of lutein, zeaxanthin, and related geometrical isomers in fruit, vegetables, wheat, and pasta products. Journal of Agricultural and Food Chemistry. 51: 1322-7. PMID 12590476 DOI: 10.1021/Jf026073E  0.416
2003 Khachik F. An efficient conversion of (3R,3'R,6'R)-lutein to (3R,3'S,6'R)-lutein (3'-epilutein) and (3R,3'R)-zeaxanthin. Journal of Natural Products. 66: 67-72. PMID 12542348 DOI: 10.1021/Np020376L  0.4
2002 Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Experimental Biology and Medicine (Maywood, N.J.). 227: 845-51. PMID 12424324 DOI: 10.1177/153537020222701002  0.419
2001 Bernstein PS, Khachik F, Carvalho LS, Muir GJ, Zhao DY, Katz NB. Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Experimental Eye Research. 72: 215-23. PMID 11180970 DOI: 10.1006/Exer.2000.0954  0.349
1999 Khachik F, Steck A, Pfander H. Isolation and structural elucidation of (13Z,13'Z,3R,3'R,6'R)-lutein from marigold flowers, kale, and human plasma Journal of Agricultural and Food Chemistry. 47: 455-461. PMID 10563916 DOI: 10.1021/Jf980823W  0.43
1998 Zhao Z, Khachik F, Richie JP, Cohen LA. Lycopene uptake and tissue disposition in male and female rats Proceedings of the Society For Experimental Biology and Medicine. 218: 109-114. PMID 9605207 DOI: 10.3181/00379727-218-44283A  0.32
1998 Khachik F, Pfander H, Traber B. Proposed Mechanisms for the Formation of Synthetic and Naturally Occurring Metabolites of Lycopene in Tomato Products and Human Serum Journal of Agricultural and Food Chemistry. 46: 4885-4890. DOI: 10.1021/Jf9803233  0.315
1998 Khachik F, Steck A, Niggli UA, Pfander H. Partial Synthesis and Structural Elucidation of the Oxidative Metabolites of Lycopene Identified in Tomato Paste, Tomato Juice, and Human Serum Journal of Agricultural and Food Chemistry. 46: 4874-4884. DOI: 10.1021/Jf980322A  0.357
1997 Khachik F, Spangler CJ, Smith JC, Canfield LM, Steck A, Pfander H. Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum Analytical Chemistry. 69: 1873-1881. PMID 9164160 DOI: 10.1021/Ac961085I  0.412
1997 King TJ, Khachik F, Bortkiewicz H, Fukushima LH, Morioka S, Bertram JS. Metabolites of dietary carotenoids as potential cancer preventive agents Pure and Applied Chemistry. 69: 2135-2140. DOI: 10.1351/Pac199769102135  0.384
1996 Narisawa T, Fukaura Y, Hasebe M, Ito M, Aizawa R, Murakoshi M, Uemura S, Khachik F, Nishino H. Inhibitory effects of natural carotenoids, α-carotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats Cancer Letters. 107: 137-142. PMID 8913278 DOI: 10.1016/0304-3835(96)04354-6  0.362
1995 Khachik F, Englert G, Beecher GR, Cecil Smith J. Isolation, structural elucidation, and partial synthesis of lutein dehydration products in extracts from human plasma Journal of Chromatography B: Biomedical Sciences and Applications. 670: 219-233. PMID 8548012 DOI: 10.1016/0378-4347(95)00169-7  0.473
1995 Khachik F, Beecher GR, Smith JC. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer Journal of Cellular Biochemistry. 58: 236-246. PMID 8538204 DOI: 10.1002/Jcb.240590830  0.357
1995 Tonucci LH, Holden JM, Beecher GR, Khachik F, Davis CS, Mulokozi G. Carotenoid content of thermally processed tomato-based food products Journal of Agricultural and Food Chemistry. 43: 579-586. DOI: 10.1021/Jf00051A005  0.384
1995 Khachik F, Beecher GR, Li BW, Englert G. Synthesis of 13C-labelled (all-E,3R,3'R)-β-β-carotene-3,3'-diol (zeaxanthin) at C(12), C(13), C(12'), and C(13') via all-E-2,7-dimethylocta-2,4,6-triene-1,8-dial-13C4 Journal of Labelled Compounds and Radiopharmaceuticals. 36: 1157-1172. DOI: 10.1002/Jlcr.2580361206  0.376
1992 Khachik F, Englert G, Daitch CE, Beecher GR, Tonucci LH, Lusby WR. Isolation and structural elucidation of the geometrical isomers of lutein and zeaxanthin in extracts from human plasma Journal of Chromatography B: Biomedical Sciences and Applications. 582: 153-166. PMID 1491035 DOI: 10.1016/0378-4347(92)80314-G  0.412
1992 Khachik F, Beecher GR, Goli MB, Lusby WR. Separation and quantitation of carotenoids in foods Methods in Enzymology. 213: 347-359. PMID 1435310 DOI: 10.1016/0076-6879(92)13136-L  0.678
1992 Khachik F, Beecher GR, Goli MB, Lusby WR, Daitch CE. Separation and quantification of carotenoids in human plasma Methods in Enzymology. 213: 205-219. PMID 1435303 DOI: 10.1016/0076-6879(92)13122-E  0.704
1992 Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma Analytical Chemistry. 64: 2111-2122. PMID 1416048 DOI: 10.1021/Ac00042A016  0.7
1992 Khachik F, Goli MB, Beecher GR, Holden J, Lusby WR, Tenorio MD, Barrera MR. Effect of food preparation on qualitative and quantitative distribution of major carotenoid constituents of tomatoes and several green vegetables Journal of Agricultural and Food Chemistry. 40: 390-398. DOI: 10.1021/Jf00015A006  0.466
1991 Khachik F, Beecher GR, Goli MB, Lusby WR. Separation, identification, and quantification of carotenoids in fruits, vegetables and human plasma by high performance liquid chromatography Pure and Applied Chemistry. 63: 71-80. DOI: 10.1351/Pac199163010071  0.439
1989 Khachik F, Beecher GR, Lusby WR. Separation, identification, and quantification of the major carotenoids in extracts of apricots, peaches, cantaloupe, and pink grapefruit by liquid chromatography Journal of Agricultural and Food Chemistry. 37: 1465-1473. DOI: 10.1021/Jf00090A003  0.45
1988 Khachik F. Liquid chromatographic artifacts and peak distortion: sample-solvent interactions in the separation of carotenoids Analytical Chemistry. 60: 807-811. PMID 3369703 DOI: 10.1021/Ac00159A015  0.4
1988 Khachik F, Beecher GR. Separation of carotenol fatty acid esters by high-performance liquid chromatography Journal of Chromatography A. 449: 119-133. PMID 3235576 DOI: 10.1016/S0021-9673(00)94373-5  0.4
1988 Khachik F, Beecher GR, Lusby WR. Separation and identification of carotenoids and carotenol fatty acid esters in some squash products by liquid chromatography. 2. Isolation and characterization of carotenoids and related esters Journal of Agricultural and Food Chemistry. 36: 938-946. DOI: 10.1021/Jf00083A011  0.379
1988 Khachik F, Beecher GR. Separation and identification of carotenoids and carotenol fatty acid esters in some squash products by liquid chromatography. 1. Quantification of carotenoids and related esters by HPLC Journal of Agricultural and Food Chemistry. 36: 929-937. DOI: 10.1021/Jf00083A010  0.392
1987 Khachik F, Beecher GR. Rebuttal on quantification of major carotenoids in raw fruits and vegetables by HPLC [3] Journal of Agricultural and Food Chemistry. 35: 850. DOI: 10.1021/Jf00077A052  0.377
1987 Khachik F, Beecher GR. Application of a C-45-β-carotene as an internal standard for the quantification of carotenoids in yellow/orange vegetables by liquid chromatography Journal of Agricultural and Food Chemistry. 35: 732-738. DOI: 10.1021/Jf00077A022  0.447
1987 KHACHIK F, BEECHER GR. ChemInform Abstract: Synthesis of C45-β-Carotene, a Potentially Useful Internal Standard for Quantification of Hydrocarbon Carotenoids by High-Performance Liquid Chromatography. Cheminform. 18. DOI: 10.1002/chin.198722275  0.317
1986 Khachik F, Beecher GR, Whittaker NF. Separation, identification, and quantification of the major carotenoid and chlorophyll constituents in extracts of several green vegetables by liquid chromatography Journal of Agricultural and Food Chemistry. 34: 603-616. DOI: 10.1021/Jf00070A006  0.49
1986 Khachik F, Beecher GR. Synthesis of C45-.beta.-carotene, a potentially useful internal standard for quantification of hydrocarbon carotenoids by high-performance liquid chromatography Industrial & Engineering Chemistry Product Research and Development. 25: 671-675. DOI: 10.1021/I300024A020  0.321
1985 Khachik F, Beecher GR. Decapreno-β-carotene as an internal standard for the quantification of the hydrocarbon carotenoids by high-performance liquid chromatography Journal of Chromatography A. 346: 237-246. PMID 3841351 DOI: 10.1016/S0021-9673(00)90509-0  0.438
1984 Beecher GR, Khachik F. Evaluation of vitamin A and carotenoid data in food composition tables Journal of the National Cancer Institute. 73: 1397-1404. PMID 6392673 DOI: 10.1093/Jnci/73.6.1397  0.355
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