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Christina Guzzo, Ph.D. - Publications

Affiliations: 
2012 Microbiology & Immunology Queen's University, Canada, Kingston, Ontario, Canada 
Area:
Immunology, Microbiology Biology, Virology Biology
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Guzzo C, Zhang P, Liu Q, Kwon AL, Uddin F, Wells AI, Schmeisser H, Cimbro R, Huang J, Doria-Rose N, Schmidt SD, Dolan MA, Connors M, Mascola JR, Lusso P. Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation. Mbio. 9. PMID 30538178 DOI: 10.1128/Mbio.00955-18  0.325
2018 Zhang P, Gorman J, Geng H, Liu Q, Lin Y, Tsybovsky Y, Go EP, Dey B, Andine T, Kwon A, Patel M, Gururani D, Uddin F, Guzzo C, Cimbro R, et al. Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer. Cell Host & Microbe. 23: 832-844.e6. PMID 29902444 DOI: 10.1016/J.Chom.2018.05.002  0.339
2018 Lusso P, Liu Q, Acharya P, Dolan M, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D. C-105 Quaternary Configuration of the HIV-1 Receptor-Binding Site Jaids Journal of Acquired Immune Deficiency Syndromes. 77: 38. DOI: 10.1097/01.Qai.0000532592.74801.1A  0.311
2017 Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, et al. Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. Science Immunology. 2. PMID 28763793 DOI: 10.1126/Sciimmunol.Aam7341  0.36
2017 Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, et al. Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nature Structural & Molecular Biology. 24: 553. PMID 28586323 DOI: 10.1038/Nsmb0617-553B  0.308
2017 Bobyk KD, Mandadapu SR, Lohith K, Guzzo C, Bhargava A, Lusso P, Bewley CA. Design of HIV co-receptor derived peptides that inhibit viral entry at submicromolar concentrations. Molecular Pharmaceutics. PMID 28494151 DOI: 10.1021/Acs.Molpharmaceut.7B00155  0.345
2017 Petes C, Wynick C, Guzzo C, Mehta D, Logan S, Banfield BW, Basta S, Cooper A, Gee K. IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages. Journal of Leukocyte Biology. PMID 28377398 DOI: 10.1189/Jlb.3A0316-098R  0.659
2017 Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, et al. Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nature Structural & Molecular Biology. PMID 28218750 DOI: 10.1038/Nsmb.3382  0.321
2017 Guzzo C, Kwon A, Zhang P, Cimbro R, Huang J, Doria-Rose N, Schmidt S, Connors M, Mascola J, Paolo P. P-C17 Critical role of V2 Sulfotyrosines in Stabilizing the HIV-1 Envelope Trimer in its Closed, Antibody-Protected Conformation Jaids Journal of Acquired Immune Deficiency Syndromes. 74: 84. DOI: 10.1097/01.Qai.0000513983.83667.1A  0.306
2016 Cimbro R, Peterson FC, Liu Q, Guzzo C, Zhang P, Miao H, Van Ryk D, Ambroggio X, Hurt DE, De Gioia L, Volkman BF, Dolan MA, Lusso P. Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry. Ebiomedicine. PMID 27389109 DOI: 10.1016/J.Ebiom.2016.06.037  0.336
2016 Guzzo C, Cimbro R, Zhang P, Jackson R, Huang J, Doria-Rose N, Schmidt S, Connors M, Mascola J, Lusso P. B-111 Sulfotyrosine-mediated V2-V3 interaction stabilizes the HIV-1 envelope trimer facilitating immune evasion Jaids Journal of Acquired Immune Deficiency Syndromes. 71: 46. DOI: 10.1097/01.Qai.0000479748.25963.5B  0.311
2016 Guzzo C, Zhang P, Lusso P, Liu Q, Cimbro R. P-D5 Two conserved tyrosines in the HIV-1 envelope V2 loop play a critical role in gp120/gp41 association Jaids Journal of Acquired Immune Deficiency Syndromes. 71: 93. DOI: 10.1097/01.Qai.0000479630.62891.A6  0.304
2016 Guzzo C, Fox J, Miao H, Volkman B, Lusso P. P-D3 Structural determinants for the selective Anti-HIV-1 activity of the all-beta alternative conformer of XCL1 Jaids Journal of Acquired Immune Deficiency Syndromes. 71: 92. DOI: 10.1097/01.Qai.0000479628.55268.F2  0.309
2015 Fox JC, Tyler RC, Guzzo C, Tuinstra RL, Peterson FC, Lusso P, Volkman BF. Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation. Acs Chemical Biology. PMID 26302421 DOI: 10.1021/Acschembio.5B00542  0.346
2015 Guzzo C, Fox JC, Miao H, Volkman BF, Lusso P. Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1. Journal of Virology. PMID 26085164 DOI: 10.1128/Jvi.01285-15  0.356
2015 Sironi F, Malnati M, Mongelli N, Cozzi P, Guzzo C, Ghezzi S, Martínez-Romero C, García-Sastre A, Lusso P, Jabes D, Biswas P. Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains. Journal of Translational Medicine. 13: 107. PMID 25888743 DOI: 10.1186/S12967-015-0461-9  0.317
2014 Cimbro R, Gallant TR, Dolan MA, Guzzo C, Zhang P, Lin Y, Miao H, Van Ryk D, Arthos J, Gorshkova I, Brown PH, Hurt DE, Lusso P. Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 111: 3152-7. PMID 24569807 DOI: 10.1073/Pnas.1314718111  0.331
2014 Guzzo C, Fox J, Lin Y, Volkman B, Lusso P, Miao H. P-D4 Inhibition of HIV-1 by the C-chemokine XCL1/Lymphotactin is dependent on high affinity binding to glycosaminoglycans (GAG) Jaids Journal of Acquired Immune Deficiency Syndromes. 67: 88. DOI: 10.1097/01.Qai.0000456193.00905.5D  0.324
2013 Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman BF, Fauci AS, Lusso P. The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. Plos Pathogens. 9: e1003852. PMID 24385911 DOI: 10.1371/Journal.Ppat.1003852  0.396
2012 Gambhir V, Yildiz C, Mulder R, Siddiqui S, Guzzo C, Szewczuk M, Gee K, Basta S. The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum. Cellular Immunology. 280: 101-7. PMID 23298864 DOI: 10.1016/J.Cellimm.2012.12.001  0.591
2012 Guzzo C, Jung M, Graveline A, Banfield BW, Gee K. IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN. Scientific Reports. 2: 974. PMID 23240078 DOI: 10.1038/Srep00974  0.657
2012 Guzzo C, Hopman WM, Che Mat NF, Wobeser W, Gee K. IL-27-induced gene expression is downregulated in HIV-infected subjects. Plos One. 7: e45706. PMID 23049843 DOI: 10.1371/Journal.Pone.0045706  0.622
2012 Guzzo C, Ayer A, Basta S, Banfield BW, Gee K. IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. Journal of Immunology (Baltimore, Md. : 1950). 188: 864-73. PMID 22156348 DOI: 10.4049/Jimmunol.1101912  0.67
2012 Guzzo C, Mat NFC, Gee K. Interleukin-27 induces a STAT1/3- and NF-κB-dependent proinflammatory cytokine profile in human monocytes (Journal of Biological Chemistry (2010) 285 (24404-24411) DOI: 10.1074/jbc.A110.112599) Journal of Biological Chemistry. 287: 8661. DOI: 10.1074/jbc.A110.112599  0.544
2011 Abdulkhalek S, Amith SR, Franchuk SL, Jayanth P, Guo M, Finlay T, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR. Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling. The Journal of Biological Chemistry. 286: 36532-49. PMID 21873432 DOI: 10.1074/Jbc.M111.237578  0.572
2011 Yeilding N, Szapary P, Brodmerkel C, Benson J, Plotnick M, Zhou H, Goyal K, Schenkel B, Giles-Komar J, Mascelli MA, Guzzo C. Development of the IL-12/23 antagonist ustekinumab in psoriasis: past, present, and future perspectives. Annals of the New York Academy of Sciences. 1222: 30-9. PMID 21434940 DOI: 10.1111/j.1749-6632.2011.05963.x  0.322
2011 Che Mat NF, Zhang X, Guzzo C, Gee K. Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 31: 363-71. PMID 21138378 DOI: 10.1089/Jir.2010.0083  0.65
2010 Finlay TM, Abdulkhalek S, Gilmour A, Guzzo C, Jayanth P, Amith SR, Gee K, Beyaert R, Szewczuk MR. Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo. Glycoconjugate Journal. 27: 583-600. PMID 20697956 DOI: 10.1007/S10719-010-9302-5  0.594
2010 Guzzo C, Che Mat NF, Gee K. Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes. The Journal of Biological Chemistry. 285: 24404-11. PMID 20519510 DOI: 10.1074/Jbc.M110.112599  0.673
2010 Guzzo C, Hopman WM, Che Mat NF, Wobeser W, Gee K. Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27. Aids (London, England). 24: 1371-4. PMID 20375875 DOI: 10.1097/Qad.0B013E3283391D2B  0.647
2010 Finlay TM, Jayanth P, Amith SR, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconjugate Journal. 27: 329-48. PMID 20213245 DOI: 10.1007/S10719-010-9281-6  0.57
2009 Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflammation & Allergy Drug Targets. 8: 40-52. PMID 19275692 DOI: 10.2174/187152809787582507  0.652
2009 Guzzo C, Che Mat NFB, Gee K. Interleukin-27 induces a pro-inflammatory cytokine and chemokine profile in resting human monocytes Cytokine. 48: 108-109. DOI: 10.1016/J.Cyto.2009.07.457  0.598
2009 Che Mat NF, Guzzo C, Gee K. IL-23 induced signaling and IL-23 receptor expression in human CD4 T cells Cytokine. 48: 108. DOI: 10.1016/J.Cyto.2009.07.456  0.636
2008 Guzzo C, Mat NFBC, Gee K. 138 Molecular mechanisms of interleukin-27-induced cytokine production in human monocytic cells Cytokine. 43: 268. DOI: 10.1016/J.Cyto.2008.07.180  0.593
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