Jil C. Tardiff - Publications

Physiology and Biophysics Yeshiva University, New York, NY, United States 
Physiology Biology, General Biophysics

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Abdullah S, Lynn ML, McConnell MT, Klass MM, Baldo AP, Schwartz SD, Tardiff JC. FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation. The Journal of Biological Chemistry. PMID 31387947 DOI: 10.1074/jbc.RA118.005098  0.4
2019 Szatkowski L, Lynn ML, Holeman T, Williams MR, Baldo AP, Tardiff JC, Schwartz SD. Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations. Acs Omega. 4: 6492-6501. PMID 31342001 DOI: 10.1021/acsomega.8b03340  0.4
2018 Williams MR, Tardiff JC, Schwartz SD. The Mechanism of Cardiac Tropomyosin Transitions on Filamentous Actin as Revealed by all Atom Steered Molecular Dynamics Simulations. The Journal of Physical Chemistry Letters. PMID 29863359 DOI: 10.1021/acs.jpclett.8b00958  0.4
2017 McConnell M, Tal Grinspan L, Williams MR, Lynn ML, Schwartz BA, Fass OZ, Schwartz SD, Tardiff JC. Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry. PMID 28603979 DOI: 10.1021/acs.biochem.7b00266  0.4
2016 Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. Plos One. 11: e0160605. PMID 27500929 DOI: 10.1371/journal.pone.0160605  0.88
2016 Behunin SM, Lopez-Pier MA, Mayfield RM, Danilo CA, Lipovka Y, Birch C, Lehman S, Tardiff JC, Gregorio CC, Konhilas JP. Liver Kinase B 1 Complex Acts as a Novel Modifier of Myofilament Function and Localizes to the Z-Disk in Cardiac Myocytes. Archives of Biochemistry and Biophysics. PMID 26971467 DOI: 10.1016/j.abb.2016.03.012  0.88
2016 Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. Atomic resolution probe for allostery in the regulatory thin filament. Proceedings of the National Academy of Sciences of the United States of America. PMID 26957598 DOI: 10.1073/pnas.1519541113  0.88
2015 Gollapudi SK, Tardiff JC, Chandra M. The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms. American Journal of Physiology. Heart and Circulatory Physiology. 308: H884-93. PMID 25681424 DOI: 10.1152/ajpheart.00528.2014  0.88
2015 Tardiff JC, Carrier L, Bers DM, Poggesi C, Ferrantini C, Coppini R, Maier LS, Ashrafian H, Huke S, van der Velden J. Targets for therapy in sarcomeric cardiomyopathies. Cardiovascular Research. 105: 457-70. PMID 25634554 DOI: 10.1093/cvr/cvv023  0.88
2015 van der Velden J, Ho CY, Tardiff JC, Olivotto I, Knollmann BC, Carrier L. Research priorities in sarcomeric cardiomyopathies. Cardiovascular Research. 105: 449-56. PMID 25631582 DOI: 10.1093/cvr/cvv019  0.88
2015 Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L. Animal and in silico models for the study of sarcomeric cardiomyopathies. Cardiovascular Research. 105: 439-48. PMID 25600962 DOI: 10.1093/cvr/cvv006  0.88
2015 Hill MG, Sekhon MK, Reed KL, Anderson CF, Borjon ND, Tardiff JC, Barber BJ. Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation Pediatric Cardiology. DOI: 10.1007/s00246-015-1250-1  0.88
2014 Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, ... ... Tardiff JC, et al. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling. 7: ra27. PMID 24643800 DOI: 10.1126/scisignal.2005046  0.88
2014 Moore RK, Abdullah S, Tardiff JC. Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: a novel pathogenic mechanism for hypertrophic cardiomyopathy. Archives of Biochemistry and Biophysics. 552: 21-8. PMID 24480310 DOI: 10.1016/j.abb.2014.01.016  0.88
2013 Moore RK, Grinspan LT, Jimenez J, Guinto PJ, Ertz-Berger B, Tardiff JC. HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice. Journal of Molecular and Cellular Cardiology. 58: 188-98. PMID 23434821 DOI: 10.1016/j.yjmcc.2013.02.004  0.88
2012 Tardiff JC. It's never too early to look: subclinical disease in sarcomeric dilated cardiomyopathy. Circulation. Cardiovascular Genetics. 5: 483-6. PMID 23074334 DOI: 10.1161/CIRCGENETICS.112.964817  0.88
2012 He H, Hoyer K, Tao H, Rice R, Jimenez J, Tardiff JC, Ingwall JS. Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific. The Journal of Physiology. 590: 5371-88. PMID 22907055 DOI: 10.1113/jphysiol.2012.234252  0.88
2012 Ford SJ, Mamidi R, Jimenez J, Tardiff JC, Chandra M. Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoform. Journal of Molecular and Cellular Cardiology. 53: 542-51. PMID 22884844 DOI: 10.1016/j.yjmcc.2012.07.018  0.88
2012 Leinwand LA, Tardiff JC, Gregorio CC. Mutations in the sensitive giant titin result in a broken heart. Circulation Research. 111: 158-61. PMID 22773424 DOI: 10.1161/RES.0b013e3182635ca2  0.88
2012 Manning EP, Tardiff JC, Schwartz SD. Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT. Journal of Molecular Biology. 421: 54-66. PMID 22579624 DOI: 10.1016/j.jmb.2012.05.008  0.88
2012 Manning EP, Guinto PJ, Tardiff JC. Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach. The Journal of Biological Chemistry. 287: 14515-23. PMID 22334656 DOI: 10.1074/jbc.M111.257436  0.88
2011 Manning EP, Tardiff JC, Schwartz SD. A model of calcium activation of the cardiac thin filament. Biochemistry. 50: 7405-13. PMID 21797264 DOI: 10.1021/bi200506k  0.88
2011 Tardiff JC. Thin filament mutations: developing an integrative approach to a complex disorder. Circulation Research. 108: 765-82. PMID 21415410 DOI: 10.1161/CIRCRESAHA.110.224170  0.88
2011 Jimenez J, Tardiff JC. Abnormal heart rate regulation in murine hearts with familial hypertrophic cardiomyopathy-related cardiac troponin T mutations. American Journal of Physiology. Heart and Circulatory Physiology. 300: H627-35. PMID 21131475 DOI: 10.1152/ajpheart.00247.2010  0.88
2010 Tardiff JC. Tropomyosin and dilated cardiomyopathy: revenge of the actinomyosin "gatekeeper". Journal of the American College of Cardiology. 55: 330-2. PMID 20117438 DOI: 10.1016/j.jacc.2009.11.018  0.88
2010 Rice R, Guinto P, Dowell-Martino C, He H, Hoyer K, Krenz M, Robbins J, Ingwall JS, Tardiff JC. Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts. Journal of Molecular and Cellular Cardiology. 48: 979-88. PMID 20004663 DOI: 10.1016/j.yjmcc.2009.11.018  0.88
2009 Guinto PJ, Haim TE, Dowell-Martino CC, Sibinga N, Tardiff JC. Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models. American Journal of Physiology. Heart and Circulatory Physiology. 297: H614-26. PMID 19502551 DOI: 10.1152/ajpheart.01143.2008  0.88
2007 Guinto PJ, Manning EP, Schwartz SD, Tardiff JC. Computational Characterization of Mutations in Cardiac Troponin T Known to Cause Familial Hypertrophic Cardiomyopathy. Journal of Theoretical & Computational Chemistry. 6: 413. PMID 26500385 DOI: 10.1142/S0219633607003271  0.88
2007 He H, Javadpour MM, Latif F, Tardiff JC, Ingwall JS. R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts. Biophysical Journal. 93: 1834-44. PMID 17526570 DOI: 10.1529/biophysj.107.107557  0.88
2007 Haim TE, Dowell C, Diamanti T, Scheuer J, Tardiff JC. Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics. Journal of Molecular and Cellular Cardiology. 42: 1098-110. PMID 17490679 DOI: 10.1016/j.yjmcc.2007.03.906  0.88
2006 Tardiff JC. Cardiac hypertrophy: stressing out the heart. The Journal of Clinical Investigation. 116: 1467-70. PMID 16741569 DOI: 10.1172/JCI28884  0.88
2005 Tardiff JC. Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Failure Reviews. 10: 237-48. PMID 16416046 DOI: 10.1007/s10741-005-5253-5  0.88
2005 Ertz-Berger BR, He H, Dowell C, Factor SM, Haim TE, Nunez S, Schwartz SD, Ingwall JS, Tardiff JC. Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 18219-24. PMID 16326803 DOI: 10.1073/pnas.0509181102  0.88
2005 Chandra M, Tschirgi ML, Tardiff JC. Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2112-9. PMID 15994854 DOI: 10.1152/ajpheart.00571.2005  0.88
2004 Tardiff JC. Myosin at the heart of the problem. The New England Journal of Medicine. 351: 424-6. PMID 15282349 DOI: 10.1056/NEJMp048142  0.88
2003 Javadpour MM, Tardiff JC, Pinz I, Ingwall JS. Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T. The Journal of Clinical Investigation. 112: 768-75. PMID 12952925 DOI: 10.1172/JCI15967  0.88
2001 Montgomery DE, Tardiff JC, Chandra M. Cardiac troponin T mutations: Correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice Journal of Physiology. 536: 583-592. PMID 11600691 DOI: 10.1111/j.1469-7793.2001.0583c.xd  0.88
2001 Chandra M, Rundell VLM, Tardiff JC, Leinwand LA, De Tombe PP, Solaro RJ. Ca2+ activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin t American Journal of Physiology - Heart and Circulatory Physiology. 280: H705-H713. PMID 11158969  0.88
2000 Tardiff JC, Hewett TE, Factor SM, Vikstrom KL, Robbins J, Leinwand LA. Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects American Journal of Physiology - Heart and Circulatory Physiology. 278. PMID 10666070  0.88
1999 Tardiff JC, Hewett TE, Palmer BM, Olsson C, Factor SM, Moore RL, Robbins J, Leinwand LA. Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 104: 469-81. PMID 10449439 DOI: 10.1172/JCI6067  0.88
1998 Tardiff JC, Factor SM, Tompkins BD, Hewett TE, Palmer BM, Moore RL, Schwartz S, Robbins J, Leinwand LA. A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 101: 2800-11. PMID 9637714 DOI: 10.1172/JCI2389  0.88
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