| Year |
Citation |
Score |
| 2023 |
Alt TB, Hoag MR, Moran GR. Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form. Archives of Biochemistry and Biophysics. 748: 109772. PMID 37820757 DOI: 10.1016/j.abb.2023.109772 |
0.396 |
|
| 2023 |
Smith MM, Moran GR. The unusual chemical sequences of mammalian dihydropyrimidine dehydrogenase revealed by transient-state analysis. Methods in Enzymology. 685: 373-403. PMID 37245908 DOI: 10.1016/bs.mie.2023.03.007 |
0.409 |
|
| 2023 |
Smith MM, Alt TB, Williams DL, Moran GR. Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from . Biochemistry. 62: 1497-1508. PMID 37071546 DOI: 10.1021/acs.biochem.3c00051 |
0.316 |
|
| 2023 |
Smith MM, Forouzesh DC, Kaley NE, Liu D, Moran GR. Mammalian dihydropyrimidine dehydrogenase: Added mechanistic details from transient-state analysis of charge transfer complexes. Archives of Biochemistry and Biophysics. 736: 109517. PMID 36681231 DOI: 10.1016/j.abb.2023.109517 |
0.358 |
|
| 2022 |
Kenjić N, Meneely KM, Wherritt DJ, Denler MC, Jackson TA, Moran GR, Lamb AL. Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. Journal of the American Chemical Society. PMID 35802469 DOI: 10.1021/jacs.2c03376 |
0.319 |
|
| 2021 |
Forouzesh DC, Moran GR. Mammalian dihydropyrimidine dehydrogenase. Archives of Biochemistry and Biophysics. 714: 109066. PMID 34717904 DOI: 10.1016/j.abb.2021.109066 |
0.329 |
|
| 2021 |
Smith MM, Beaupre BA, Fourozesh DC, Meneely KM, Lamb AL, Moran GR. Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of GTP Cyclohydrolase II. Biochemistry. 60: 3027-3039. PMID 34569786 DOI: 10.1021/acs.biochem.1c00511 |
0.374 |
|
| 2021 |
Beaupre BA, Forouzesh DC, Butrin A, Liu D, Moran GR. Perturbing the Movement of Hydrogens to Delineate and Assign Events in the Reductive Activation and Turnover of Porcine Dihydropyrimidine Dehydrogenase. Biochemistry. 60: 1764-1775. PMID 34032117 DOI: 10.1021/acs.biochem.1c00243 |
0.308 |
|
| 2021 |
Forouzesh DC, Beaupre BA, Butrin A, Wawrzak Z, Liu D, Moran GR. The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. Biochemistry. PMID 33755421 DOI: 10.1021/acs.biochem.1c00096 |
0.341 |
|
| 2020 |
O'Neill AG, Beaupre BA, Zheng Y, Liu D, Moran GR. NfoR, Chromate Reductase or FMN reductase? Applied and Environmental Microbiology. PMID 32887719 DOI: 10.1128/AEM.01758-20 |
0.379 |
|
| 2020 |
Beaupre BA, Reabe KR, Roman JV, Moran GR. Hydrogen movements in the oxidative half-reaction of kynurenine 3-monooxygenase from Pseudomonas fluorescens reveal the mechanism of hydroxylation. Archives of Biochemistry and Biophysics. 690: 108474. PMID 32687799 DOI: 10.1016/j.abb.2020.108474 |
0.336 |
|
| 2020 |
Beaupre BA, Forouzesh DC, Moran GR. Transient State Analysis of Porcine Dihydropyrimidine Dehydrogenase Reveals Reductive Activation by NADPH. Biochemistry. PMID 32516529 DOI: 10.1021/acs.biochem.0c00223 |
0.376 |
|
| 2019 |
Roman JV, Melkonian TR, Silvaggi N, Moran GR. Transient State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States. Biochemistry. PMID 31478653 DOI: 10.1021/Acs.Biochem.9B00518 |
0.347 |
|
| 2017 |
Moran GR, Hoag MR. The enzyme: Renalase. Archives of Biochemistry and Biophysics. PMID 28558965 DOI: 10.1016/J.Abb.2017.05.015 |
0.47 |
|
| 2016 |
Beaupre BA, Roman JV, Hoag MR, Meneely KM, Silvaggi NR, Lamb AL, Moran GR. Ligand binding phenomena that pertain to the metabolic function of renalase. Archives of Biochemistry and Biophysics. PMID 27769837 DOI: 10.1016/J.Abb.2016.10.011 |
0.449 |
|
| 2016 |
Peek J, Roman J, Moran GR, Christendat D. Structurally diverse dehydroshikimate dehydratase variants participate in microbial quinate catabolism. Molecular Microbiology. PMID 27706847 DOI: 10.1111/Mmi.13542 |
0.383 |
|
| 2016 |
Meneely KM, Sundlov JA, Gulick AM, Moran GR, Lamb AL. An Open and Shut Case: The Interaction of Magnesium with MST Enzymes. Journal of the American Chemical Society. PMID 27373320 DOI: 10.1021/Jacs.6B05134 |
0.495 |
|
| 2015 |
Han L, Schwabacher AW, Moran GR, Silvaggi NR. Streptomyces wadayamensis MppP is a PLP-Dependent L-Arginine α-deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway. Biochemistry. PMID 26551990 DOI: 10.1021/Acs.Biochem.5B01016 |
0.443 |
|
| 2015 |
Beaupre BA, Hoag MR, Moran GR. Renalase does not catalyze the oxidation of catecholamines. Archives of Biochemistry and Biophysics. 579: 62-6. PMID 26049000 DOI: 10.1016/J.Abb.2015.05.016 |
0.449 |
|
| 2015 |
Hoag MR, Roman J, Beaupre BA, Silvaggi NR, Moran GR. Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6-Dihydro-β-NAD(P) Oxidase Activity from Pseudomonas phaseolicola. Biochemistry. 54: 3791-802. PMID 26016690 DOI: 10.1021/Acs.Biochem.5B00451 |
0.479 |
|
| 2015 |
Moran GR. The catalytic function of renalase: A decade of phantoms. Biochimica Et Biophysica Acta. PMID 25900362 DOI: 10.1016/J.Bbapap.2015.04.010 |
0.411 |
|
| 2015 |
Beaupre BA, Hoag MR, Roman J, Försterling FH, Moran GR. Metabolic function for human renalase: oxidation of isomeric forms of β-NAD(P)H that are inhibitory to primary metabolism. Biochemistry. 54: 795-806. PMID 25531177 DOI: 10.1021/Bi5013436 |
0.348 |
|
| 2015 |
Shah DD, Moran GR. 4-hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase: 2-oxo acid-dependent oxygenases of importance to agriculture and medicine Rsc Metallobiology. 2015: 438-457. DOI: 10.1039/9781782621959-00438 |
0.63 |
|
| 2014 |
Wójcik A, Broclawik E, Siegbahn PE, Lundberg M, Moran G, Borowski T. Role of substrate positioning in the catalytic reaction of 4-hydroxyphenylpyruvate dioxygenase-A QM/MM Study. Journal of the American Chemical Society. 136: 14472-85. PMID 25157877 DOI: 10.1021/Ja506378U |
0.368 |
|
| 2014 |
Youngblut M, Pauly DJ, Stein N, Walters D, Conrad JA, Moran GR, Bennett B, Pacheco AA. Shewanella oneidensis cytochrome c nitrite reductase (ccNiR) does not disproportionate hydroxylamine to ammonia and nitrite, despite a strongly favorable driving force. Biochemistry. 53: 2136-44. PMID 24645742 DOI: 10.1021/Bi401705D |
0.435 |
|
| 2014 |
Moran GR. 4-Hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase: exemplars of the α-keto acid dependent oxygenases. Archives of Biochemistry and Biophysics. 544: 58-68. PMID 24211436 DOI: 10.1016/J.Abb.2013.10.022 |
0.412 |
|
| 2013 |
Beaupre BA, Hoag MR, Carmichael BR, Moran GR. Kinetics and equilibria of the reductive and oxidative half-reactions of human renalase with α-NADPH. Biochemistry. 52: 8929-37. PMID 24266457 DOI: 10.1021/Bi401185M |
0.402 |
|
| 2013 |
Beaupre BA, Carmichael BR, Hoag MR, Shah DD, Moran GR. Renalase is an α-NAD(P)H oxidase/anomerase. Journal of the American Chemical Society. 135: 13980-7. PMID 23964689 DOI: 10.1021/Ja407384H |
0.701 |
|
| 2013 |
Shah DD, Conrad JA, Moran GR. Intermediate partitioning kinetic isotope effects for the NIH shift of 4-hydroxyphenylpyruvate dioxygenase and the hydroxylation reaction of hydroxymandelate synthase reveal mechanistic complexity. Biochemistry. 52: 6097-107. PMID 23941465 DOI: 10.1021/Bi400534Q |
0.738 |
|
| 2012 |
Crozier-Reabe K, Moran GR. Form follows function: structural and catalytic variation in the class a flavoprotein monooxygenases. International Journal of Molecular Sciences. 13: 15601-39. PMID 23443084 DOI: 10.3390/Ijms131215601 |
0.743 |
|
| 2011 |
Diebold AR, Brown-Marshall CD, Neidig ML, Brownlee JM, Moran GR, Solomon EI. Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation. Journal of the American Chemical Society. 133: 18148-60. PMID 21981763 DOI: 10.1021/Ja202549Q |
0.392 |
|
| 2011 |
He P, Moran GR. Structural and mechanistic comparisons of the metal-binding members of the vicinal oxygen chelate (VOC) superfamily. Journal of Inorganic Biochemistry. 105: 1259-72. PMID 21820381 DOI: 10.1016/J.Jinorgbio.2011.06.006 |
0.599 |
|
| 2011 |
Shah DD, Conrad JA, Heinz B, Brownlee JM, Moran GR. Evidence for the mechanism of hydroxylation by 4-hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase from intermediate partitioning in active site variants. Biochemistry. 50: 7694-704. PMID 21815644 DOI: 10.1021/Bi2009344 |
0.741 |
|
| 2010 |
Diebold AR, Neidig ML, Moran GR, Straganz GD, Solomon EI. The three-his triad in Dke1: comparisons to the classical facial triad. Biochemistry. 49: 6945-52. PMID 20695531 DOI: 10.1021/Bi100892W |
0.425 |
|
| 2010 |
Brownlee JM, Heinz B, Bates J, Moran GR. Product analysis and inhibition studies of a causative Asn to Ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria. Biochemistry. 49: 7218-26. PMID 20677779 DOI: 10.1021/Bi1008112 |
0.643 |
|
| 2010 |
He P, Conrad JA, Moran GR. The rate-limiting catalytic steps of hydroxymandelate synthase from Amycolatopsis orientalis. Biochemistry. 49: 1998-2007. PMID 20112984 DOI: 10.1021/Bi901674Q |
0.624 |
|
| 2009 |
He P, Moran GR. We two alone will sing: the two-substrate alpha-keto acid-dependent oxygenases. Current Opinion in Chemical Biology. 13: 443-50. PMID 19625206 DOI: 10.1016/J.Cbpa.2009.06.012 |
0.619 |
|
| 2008 |
Crozier-Reabe KR, Phillips RS, Moran GR. Kynurenine 3-monooxygenase from Pseudomonas fluorescens: substrate-like inhibitors both stimulate flavin reduction and stabilize the flavin-peroxo intermediate yet result in the production of hydrogen peroxide. Biochemistry. 47: 12420-33. PMID 18954092 DOI: 10.1021/Bi8010434 |
0.74 |
|
| 2008 |
Conrad JA, Moran GR. The Interaction of Hydroxymandelate Synthase with the 4-Hydroxyphenylpyruvate Dioxygenase Inhibitor: NTBC. Inorganica Chimica Acta. 361: 1197-1201. PMID 18496607 DOI: 10.1016/J.Ica.2007.07.036 |
0.432 |
|
| 2008 |
Brownlee J, He P, Moran GR, Harrison DH. Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate. Biochemistry. 47: 2002-13. PMID 18215022 DOI: 10.1021/Bi701438R |
0.653 |
|
| 2007 |
Keith KE, Killip L, He P, Moran GR, Valvano MA. Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate. Journal of Bacteriology. 189: 9057-65. PMID 17933889 DOI: 10.1128/Jb.00436-07 |
0.571 |
|
| 2007 |
Purpero V, Moran GR. The diverse and pervasive chemistries of the alpha-keto acid dependent enzymes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 12: 587-601. PMID 17431691 DOI: 10.1007/S00775-007-0231-0 |
0.806 |
|
| 2007 |
Crozier KR, Moran GR. Heterologous expression and purification of kynurenine-3-monooxygenase from Pseudomonas fluorescens strain 17400. Protein Expression and Purification. 51: 324-33. PMID 16973376 DOI: 10.1016/J.Pep.2006.07.024 |
0.43 |
|
| 2006 |
Neidig ML, Brown CD, Kavana M, Choroba OW, Spencer JB, Moran GR, Solomon EI. Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases. Journal of Inorganic Biochemistry. 100: 2108-16. PMID 17070917 DOI: 10.1016/J.Jinorgbio.2006.08.021 |
0.489 |
|
| 2006 |
Neidig ML, Decker A, Choroba OW, Huang F, Kavana M, Moran GR, Spencer JB, Solomon EI. Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12966-73. PMID 16920789 DOI: 10.1073/Pnas.0605067103 |
0.469 |
|
| 2006 |
Purpero VM, Moran GR. Catalytic, noncatalytic, and inhibitory phenomena: kinetic analysis of (4-hydroxyphenyl)pyruvate dioxygenase from Arabidopsis thaliana. Biochemistry. 45: 6044-55. PMID 16681377 DOI: 10.1021/Bi052409C |
0.809 |
|
| 2005 |
Neidig ML, Decker A, Kavana M, Moran GR, Solomon EI. Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: active site contributions to drug inhibition. Biochemical and Biophysical Research Communications. 338: 206-14. PMID 16197918 DOI: 10.1016/J.Bbrc.2005.08.242 |
0.385 |
|
| 2005 |
Johnson-Winters K, Purpero VM, Kavana M, Moran GR. Accumulation of multiple intermediates in the catalytic cycle of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis. Biochemistry. 44: 7189-99. PMID 15882057 DOI: 10.1021/Bi047625K |
0.785 |
|
| 2005 |
Moran GR. 4-Hydroxyphenylpyruvate dioxygenase. Archives of Biochemistry and Biophysics. 433: 117-28. PMID 15581571 DOI: 10.1016/J.Abb.2004.08.015 |
0.521 |
|
| 2004 |
Brownlee JM, Johnson-Winters K, Harrison DH, Moran GR. Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC. Biochemistry. 43: 6370-7. PMID 15157070 DOI: 10.1021/Bi049317S |
0.754 |
|
| 2004 |
Neidig ML, Kavana M, Moran GR, Solomon EI. CD and MCD studies of the non-heme ferrous active site in (4-hydroxyphenyl)pyruvate dioxygenase: correlation between oxygen activation in the extradiol and alpha-KG-dependent dioxygenases. Journal of the American Chemical Society. 126: 4486-7. PMID 15070344 DOI: 10.1021/Ja0316521 |
0.41 |
|
| 2004 |
Amaya AA, Brzezinski KT, Farrington N, Moran GR. Kinetic analysis of human homogentisate 1,2-dioxygenase. Archives of Biochemistry and Biophysics. 421: 135-42. PMID 14678794 DOI: 10.1016/J.Abb.2003.10.014 |
0.473 |
|
| 2003 |
Kavana M, Moran GR. Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry. 42: 10238-45. PMID 12939152 DOI: 10.1021/Bi034658B |
0.371 |
|
| 2003 |
Johnson-Winters K, Purpero VM, Kavana M, Nelson T, Moran GR. (4-Hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis: the basis for ordered substrate addition. Biochemistry. 42: 2072-80. PMID 12590595 DOI: 10.1021/Bi026499M |
0.769 |
|
| 2003 |
Moran GR, Purpero VM, Johnson K, Kavana M. Alpha-keto acids and 4-hydroxyphenylpyruvate dioxygenase Journal of Inorganic Biochemistry. 96: 194. DOI: 10.1016/S0162-0134(03)80715-8 |
0.747 |
|
| 2003 |
Kavana M, Purpero VM, Moran GR. Studies of the interaction of streptomyces avermitilis (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor NTBC Journal of Inorganic Biochemistry. 96: 166. DOI: 10.1016/S0162-0134(03)80670-0 |
0.743 |
|
| 2002 |
Daubner SC, Moran GR, Fitzpatrick PF. Role of tryptophan hydroxylase phe313 in determining substrate specificity. Biochemical and Biophysical Research Communications. 292: 639-41. PMID 11922614 DOI: 10.1006/Bbrc.2002.6719 |
0.623 |
|
| 2000 |
Moran GR, Derecskei-Kovacs A, Hillas PJ, Fitzpatrick PF. On the catalytic mechanism of tryptophan hydroxylase Journal of the American Chemical Society. 122: 4535-4541. DOI: 10.1021/Ja994479A |
0.581 |
|
| 1999 |
Moran GR, Phillips RS, Fitzpatrick PF. Influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates. Biochemistry. 38: 16283-9. PMID 10587452 DOI: 10.1021/Bi991983J |
0.635 |
|
| 1999 |
Moran GR, Entsch B, Palfey BA, Ballou DP. Mechanistic insights into p-hydroxybenzoate hydroxylase from studies of the mutant Ser212Ala. Biochemistry. 38: 6292-9. PMID 10320359 DOI: 10.1021/Bi990021+ |
0.642 |
|
| 1999 |
Palfey BA, Moran GR, Entsch B, Ballou DP, Massey V. Substrate recognition by "password" in p-hydroxybenzoate hydroxylase. Biochemistry. 38: 1153-8. PMID 9930974 DOI: 10.1021/Bi9826613 |
0.7 |
|
| 1999 |
Moran GR, Fitzpatrick PF. A continuous fluorescence assay for tryptophan hydroxylase. Analytical Biochemistry. 266: 148-52. PMID 9887224 DOI: 10.1006/Abio.1998.2956 |
0.573 |
|
| 1999 |
Palfey BA, Moran GR, Entsch B, Ballou DP, Massey V. Substrate recognition by "password" in p-hydroxybenzoate hydroxylase Biochemistry. 38: x-1158. |
0.625 |
|
| 1998 |
Moran GR, Daubner SC, Fitzpatrick PF. Expression and characterization of the catalytic core of tryptophan hydroxylase. The Journal of Biological Chemistry. 273: 12259-66. PMID 9575176 DOI: 10.1074/Jbc.273.20.12259 |
0.57 |
|
| 1997 |
Moran GR, Entsch B, Palfey BA, Ballou DP. Electrostatic effects on substrate activation in para-hydroxybenzoate hydroxylase: studies of the mutant lysine 297 methionine. Biochemistry. 36: 7548-56. PMID 9200706 DOI: 10.1021/Bi9706327 |
0.666 |
|
| 1997 |
Moran GR. Purification of a stable active mutant of tryptophan hydroxylase Faseb Journal. 11. |
0.378 |
|
| 1996 |
Moran GR, Entsch B, Palfey BA, Ballou DP. Evidence for flavin movement in the function of p-hydroxybenzoate hydroxylase from studies of the mutant Arg220Lys. Biochemistry. 35: 9278-85. PMID 8703933 DOI: 10.1021/Bi960360S |
0.604 |
|
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