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Robert A. Fecik - Publications

Affiliations: 
Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Organic Chemistry, Biochemistry
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Fiers WD, Dodge GJ, Li Y, Smith JL, Fecik RA, Aldrich CC. Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates. Chemical Science (Royal Society of Chemistry : 2010). 6: 5027-5033. PMID 26366283 DOI: 10.1039/C5Sc01505G  0.335
2015 Li Y, Dodge GJ, Fiers WD, Fecik RA, Smith JL, Aldrich CC. Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase. Journal of the American Chemical Society. 137: 7003-6. PMID 26027428 DOI: 10.1021/Jacs.5B02325  0.394
2015 Murray BC, Peterson MT, Fecik RA. Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers. Natural Product Reports. 32: 654-62. PMID 25677951 DOI: 10.1039/C4Np00036F  0.377
2014 Li Y, Fiers WD, Bernard SM, Smith JL, Aldrich CC, Fecik RA. Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains. Acs Chemical Biology. 9: 2914-22. PMID 25299319 DOI: 10.1021/Cb5006883  0.361
2010 Leggans EK, Akey DL, Smith JL, Fecik RA. A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins. Bioorganic & Medicinal Chemistry Letters. 20: 5939-42. PMID 20801036 DOI: 10.1016/J.Bmcl.2010.05.089  0.367
2009 Balasubramanian R, Raghavan B, Begaye A, Sackett DL, Fecik RA. Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues. Journal of Medicinal Chemistry. 52: 238-40. PMID 19102699 DOI: 10.1021/Jm8013579  0.523
2008 Gupta S, Lakshmanan V, Kim BS, Fecik R, Reynolds KA. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1609-16. PMID 18512859 DOI: 10.1002/Cbic.200700635  0.373
2008 Balasubramanian R, Raghavan B, Steele JC, Sackett DL, Fecik RA. Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2996-9. PMID 18411048 DOI: 10.1016/J.Bmcl.2008.03.046  0.497
2008 Raghavan B, Balasubramanian R, Steele JC, Sackett DL, Fecik RA. Cytotoxic simplified tubulysin analogues. Journal of Medicinal Chemistry. 51: 1530-3. PMID 18314944 DOI: 10.1021/Jm701321P  0.523
2007 Fecik RA. Natural product biosynthesis moves in vitro. Nature Chemical Biology. 3: 531-2. PMID 17710095 DOI: 10.1038/Nchembio0907-531  0.353
2006 Venkatraman L, Salomon CE, Sherman DH, Fecik RA. Total synthesis of narbonolide and biotransformation to pikromycin. The Journal of Organic Chemistry. 71: 9853-6. PMID 17168607 DOI: 10.1021/Jo062047U  0.375
2006 Giraldes JW, Akey DL, Kittendorf JD, Sherman DH, Smith JL, Fecik RA. Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2: 531-6. PMID 16969373 DOI: 10.1038/Nchembio822  0.442
2006 Akey DL, Kittendorf JD, Giraldes JW, Fecik RA, Sherman DH, Smith JL. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2: 537-42. PMID 16969372 DOI: 10.1038/Nchembio824  0.409
2005 Venkatraman L, Aldrich CC, Sherman DH, Fecik RA. Formal total synthesis of the polyketide macrolactone narbonolide. The Journal of Organic Chemistry. 70: 7267-72. PMID 16122247 DOI: 10.1021/Jo050924A  0.409
2005 Aldrich CC, Venkatraman L, Sherman DH, Fecik RA. Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. Journal of the American Chemical Society. 127: 8910-1. PMID 15969542 DOI: 10.1021/Ja0504340  0.459
2005 Aldrich CC, Beck BJ, Fecik RA, Sherman DH. Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. Journal of the American Chemical Society. 127: 8441-52. PMID 15941278 DOI: 10.1021/Ja042592H  0.405
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society. 125: 12551-7. PMID 14531700 DOI: 10.1021/Ja034841S  0.407
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society. 125: 4682-3. PMID 12696866 DOI: 10.1021/Ja029974C  0.421
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