Olga Gursky, PhD - Publications

Affiliations: 
Physiology and Biophysics Boston University, Boston, MA, United States 
Area:
General Biophysics

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jayaraman S, Chavez OR, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 158712. PMID 32289504 DOI: 10.1016/j.bbalip.2020.158712  0.68
2020 Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A. Journal of Molecular Biology. PMID 32035904 DOI: 10.1016/j.jmb.2020.01.029  0.48
2019 Jayaraman S, Fändrich M, Gursky O. Synergy between serum amyloid A and secretory phospholipase A suggests a vital role for an ancient protein in lipid clearance. Elife. 8. PMID 31111824 DOI: 10.7554/eLife.46630  0.68
2019 Jayaraman S, Baveghems C, Chavez OR, Rivas-Urbina A, Sánchez-Quesada JL, Gursky O. Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30844432 DOI: 10.1016/j.bbalip.2019.03.001  0.68
2018 Morgado I, Panahi A, Burwash AG, Das M, Straub JE, Gursky O. Molecular insights into human hereditary apoA-I amyloidosis caused by Glu34Lys mutation. Biochemistry. PMID 30184436 DOI: 10.1021/acs.biochem.8b00817  1
2018 Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR. Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry. PMID 30004693 DOI: 10.1021/acs.biochem.8b00538  1
2018 Jayaraman S, Gantz DL, Haupt C, Fändrich M, Gursky O. Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner. Chemical Communications (Cambridge, England). PMID 29565436 DOI: 10.1039/C8CC01424H  0.68
2017 Jayaraman S, Gantz DL, Haupt C, Gursky O. Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28743750 DOI: 10.1073/pnas.1707120114  0.68
2017 Frame NM, Jayaraman S, Gantz DL, Gursky O. Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response. Journal of Structural Biology. PMID 28645735 DOI: 10.1016/j.jsb.2017.06.007  0.68
2016 Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-2. PMID 28042708 DOI: 10.1080/13506129.2016.1269737  1
2016 Jayaraman S, Sánchez-Quesada JL, Gursky O. Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases. Biochimica Et Biophysica Acta. PMID 27768903 DOI: 10.1016/j.bbadis.2016.10.010  0.68
2016 Jayaraman S, Haupt C, Gursky O. Paradoxical Effects of Serum Amyloid A on the Lipoprotein Oxidation Suggest a New Antioxidant Function of SAA. Journal of Lipid Research. PMID 27744369 DOI: 10.1194/jlr.M071191  0.68
2016 Rull A, Jayaraman S, Gantz DL, Rivas-Urbina A, Pérez-Cuellar M, Ordóñez-Llanos J, Sánchez-Quesada JL, Gursky O. Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation. Biochimica Et Biophysica Acta. PMID 27233433 DOI: 10.1016/j.bbalip.2016.05.008  1
2016 Frame NM, Gursky O. Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. Febs Letters. 590: 866-79. PMID 26918388 DOI: 10.1002/1873-3468.12116  1
2015 Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? Journal of Molecular Biology. PMID 26562506 DOI: 10.1016/j.jmb.2015.10.029  1
2015 Das M, Gursky O. Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights. Advances in Experimental Medicine and Biology. 855: 175-211. PMID 26149931 DOI: 10.1007/978-3-319-17344-3_8  1
2015 Jayaraman S, Haupt C, Gursky O. Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL. Journal of Lipid Research. 56: 1531-42. PMID 26022803 DOI: 10.1194/jlr.M059162  1
2015 Gursky O. Structural stability and functional remodeling of high-density lipoproteins. Febs Letters. 589: 2627-39. PMID 25749369 DOI: 10.1016/j.febslet.2015.02.028  1
2014 Das M, Mei X, Jayaraman S, Atkinson D, Gursky O. Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. The Febs Journal. 281: 2525-42. PMID 24702826 DOI: 10.1111/febs.12809  1
2014 Gursky O. Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men. Febs Letters. 588: 845-50. PMID 24561203 DOI: 10.1016/j.febslet.2014.01.066  1
2013 Lu M, Gursky O. Aggregation and fusion of low-density lipoproteins in vivo and in vitro. Biomolecular Concepts. 4: 501-18. PMID 25197325 DOI: 10.1515/bmc-2013-0016  1
2013 Gursky O, Jones MK, Mei X, Segrest JP, Atkinson D. Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I. Journal of Lipid Research. 54: 3244-57. PMID 24038317 DOI: 10.1194/jlr.R037911  1
2013 Meyers NL, Wang L, Gursky O, Small DM. Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces. Journal of Lipid Research. 54: 1927-38. PMID 23670531 DOI: 10.1194/jlr.M037531  1
2013 Gursky O. Crystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil. Journal of Molecular Biology. 425: 1-16. PMID 23041415 DOI: 10.1016/j.jmb.2012.09.027  1
2012 Lu M, Gantz DL, Herscovitz H, Gursky O. Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis. Journal of Lipid Research. 53: 2175-85. PMID 22855737 DOI: 10.1194/jlr.M029629  1
2012 Gao X, Yuan S, Jayaraman S, Gursky O. Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL. Biochemistry. 51: 4633-41. PMID 22631438 DOI: 10.1021/bi300555d  1
2012 Gursky O, Mei X, Atkinson D. The crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment. Biochemistry. 51: 10-8. PMID 22229410 DOI: 10.1021/bi2017014  1
2012 Jayaraman S, Cavigiolio G, Gursky O. Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis. The Biochemical Journal. 442: 703-12. PMID 22150513 DOI: 10.1042/BJ20111831  1
2011 Guha M, Gursky O. Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH. Journal of Lipids. 2011: 493720. PMID 21773050 DOI: 10.1155/2011/493720  1
2011 Jayaraman S, Jasuja R, Zakharov MN, Gursky O. Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface. Biochemistry. 50: 3919-27. PMID 21452855 DOI: 10.1021/bi200090y  1
2011 Jayaraman S, Gantz DL, Gursky O. Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets. Journal of Lipid Research. 52: 549-57. PMID 21220788 DOI: 10.1194/jlr.M012567  1
2011 Gao X, Jayaraman S, Wally J, Guha M, Lu M, Atkinson D, Gursky O. Application of circular dichroism to lipoproteins: Structure, stability and remodeling of good and bad cholesterol Circular Dichroism: Theory and Spectroscopy. 175-215.  1
2010 Klimtchuk ES, Gursky O, Patel RS, Laporte KL, Connors LH, Skinner M, Seldin DC. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain. Biochemistry. 49: 9848-57. PMID 20936823 DOI: 10.1021/bi101351c  1
2010 Guha M, Gursky O. Effects of oxidation on structural stability and remodeling of human very low density lipoprotein. Biochemistry. 49: 9584-93. PMID 20919745 DOI: 10.1021/bi101391z  1
2010 Benjwal S, Gursky O. Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins. Proteins. 78: 1175-85. PMID 19927327 DOI: 10.1002/prot.22637  1
2010 Jayaraman S, Benjwal S, Gantz DL, Gursky O. Effects of cholesterol on thermal stability of discoidal high density lipoproteins. Journal of Lipid Research. 51: 324-33. PMID 19700415 DOI: 10.1194/jlr.M000117  1
2009 Gao X, Yuan S, Jayaraman S, Gursky O. Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition. Journal of Molecular Biology. 387: 628-38. PMID 19236880 DOI: 10.1016/j.jmb.2009.02.036  1
2008 Guha M, Gao X, Jayaraman S, Gursky O. Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered. Biochemistry. 47: 11393-7. PMID 18839964 DOI: 10.1021/bi8014746  1
2008 Guha M, Gantz DL, Gursky O. Effects of acyl chain length, unsaturation, and pH on thermal stability of model discoidal HDLs. Journal of Lipid Research. 49: 1752-61. PMID 18456639 DOI: 10.1194/jlr.M800106-JLR200  1
2008 Jayaraman S, Gantz DL, Gursky O. Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins. Biochemistry. 47: 3875-82. PMID 18302337 DOI: 10.1021/bi7023783  1
2008 Gao X, Jayaraman S, Gursky O. Mild oxidation promotes and advanced oxidation impairs remodeling of human high-density lipoprotein in vitro. Journal of Molecular Biology. 376: 997-1007. PMID 18190928 DOI: 10.1016/j.jmb.2007.12.030  1
2007 Guha M, England C, Herscovitz H, Gursky O. Thermal transitions in human very-low-density lipoprotein: fusion, rupture, and dissociation of HDL-like particles. Biochemistry. 46: 6043-9. PMID 17469851 DOI: 10.1021/bi7001532  1
2007 Jayaraman S, Gantz DL, Gursky O. Effects of oxidation on the structure and stability of human low-density lipoprotein. Biochemistry. 46: 5790-7. PMID 17444660 DOI: 10.1021/bi700225a  1
2007 Benjwal S, Jayaraman S, Gursky O. Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes. Biochemistry. 46: 4184-94. PMID 17341095 DOI: 10.1021/bi062175c  1
2007 Gursky O. Does alpha-helix folding necessarily provide an energy source for the protein-lipid binding? Protein and Peptide Letters. 14: 171-4. PMID 17305604 DOI: 10.2174/092986607779816023  1
2006 Jayaraman S, Gantz DL, Gursky O. Effects of salt on the thermal stability of human plasma high-density lipoprotein. Biochemistry. 45: 4620-8. PMID 16584197 DOI: 10.1021/bi0524565  1
2006 Benjwal S, Verma S, Röhm KH, Gursky O. Monitoring protein aggregation during thermal unfolding in circular dichroism experiments. Protein Science : a Publication of the Protein Society. 15: 635-9. PMID 16452626 DOI: 10.1110/ps.051917406  1
2005 Benjwal S, Jayaraman S, Gursky O. Electrostatic effects on the stability of discoidal high-density lipoproteins. Biochemistry. 44: 10218-26. PMID 16042399 DOI: 10.1021/bi050781m  1
2005 Gursky O. Apolipoprotein structure and dynamics. Current Opinion in Lipidology. 16: 287-94. PMID 15891389  1
2005 Chung CM, Chiu JD, Connors LH, Gursky O, Lim A, Dykstra AB, Liepnieks J, Benson MD, Costello CE, Skinner M, Walsh MT. Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma. Biophysical Journal. 88: 4232-42. PMID 15792972 DOI: 10.1529/biophysj.105.061317  1
2005 Jayaraman S, Gantz D, Gursky O. Structural basis for thermal stability of human low-density lipoprotein. Biochemistry. 44: 3965-71. PMID 15751972 DOI: 10.1021/bi047493v  1
2005 Jayaraman S, Gantz DL, Gursky O. Kinetic stabilization and fusion of apolipoprotein A-2:DMPC disks: comparison with apoA-1 and apoC-1. Biophysical Journal. 88: 2907-18. PMID 15681655 DOI: 10.1529/biophysj.104.055921  1
2004 Jayaraman S, Gantz DL, Gursky O. Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins. Biochemistry. 43: 5520-31. PMID 15122918 DOI: 10.1021/bi036274r  1
2003 Fang Y, Gursky O, Atkinson D. Lipid-binding studies of human apolipoprotein A-I and its terminally truncated mutants. Biochemistry. 42: 13260-8. PMID 14609337 DOI: 10.1021/bi0354031  1
2003 Fang Y, Gursky O, Atkinson D. Structural studies of N- and C-terminally truncated human apolipoprotein A-I. Biochemistry. 42: 6881-90. PMID 12779343 DOI: 10.1021/bi034152t  1
2003 Mehta R, Gantz DL, Gursky O. Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins. Biochemistry. 42: 4751-8. PMID 12705839 DOI: 10.1021/bi0341253  1
2003 Mehta R, Gantz DL, Gursky O. Human plasma high-density lipoproteins are stabilized by kinetic factors. Journal of Molecular Biology. 328: 183-92. PMID 12684007 DOI: 10.1016/S0022-2836(03)00155-4  1
2002 Gursky O, Ranjana, Gantz DL. Complex of human apolipoprotein C-1 with phospholipid: thermodynamic or kinetic stability? Biochemistry. 41: 7373-84. PMID 12044170 DOI: 10.1021/bi025588w  1
2001 Gursky O. Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: Far- and near-UV CD study Biochemistry. 40: 12178-12185. PMID 11580293 DOI: 10.1021/bi0111505  1
2000 Gorshkova IN, Liadaki K, Gursky O, Atkinson D, Zannis VI. Probing the lipid-free structure and stability of apolipoprotein A-I by mutation Biochemistry. 39: 15910-15919. PMID 11123918 DOI: 10.1021/bi0014406  1
2000 Gursky O, Aleshkov S. Temperature-dependent β-sheet formation in β-amyloid Aβ1-40 peptide in water: Uncoupling β-structure folding from aggregation Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1476: 93-102. PMID 10606771 DOI: 10.1016/S0167-4838(99)00228-9  1
1999 Gursky O. Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide Protein Science. 8: 2055-2064. PMID 10548051  1
1998 Gursky O, Atkinson D. Thermodynamic analysis of human plasma apolipoprotein C-1: High temperature unfolding and low-temperature oligomer dissociation Biochemistry. 37: 1283-1291. PMID 9477954 DOI: 10.1021/bi971801q  1
1996 Gursky O, Atkinson D. High- and low-temperature unfolding of human high-density apolipoprotein A-2 Protein Science. 5: 1874-1882. PMID 8880911  1
1996 Gursky O, Atkinson D. Thermal unfolding of human high-density apolipoprotein A-1: Implications for a lipid-free molten globular state Proceedings of the National Academy of Sciences of the United States of America. 93: 2991-2995. PMID 8610156 DOI: 10.1073/pnas.93.7.2991  1
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