| Year |
Citation |
Score |
| 2023 |
Shahbazi Nia S, Hossain MA, Ji G, Jonnalagadda SK, Obeng S, Rahman MA, Sifat AE, Nozohouri S, Blackwell C, Patel D, Thompson J, Runyon S, Hiranita T, McCurdy CR, McMahon L, et al. Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands. European Journal of Medicinal Chemistry. 254: 115309. PMID 37054561 DOI: 10.1016/j.ejmech.2023.115309 |
0.315 |
|
| 2022 |
Obeng S, León F, Patel A, Zuarth Gonzalez JD, Da Silva LC, Restrepo LF, Gamez-Jimenez LR, Ho NP, Guerrero Calvache MP, Pallares VL, Helmes JA, Shiomitsu SK, Soto PL, McCurdy CR, McMahon LR, et al. Interactive Effects of µ-Opioid and Adrenergic-α Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine. The Journal of Pharmacology and Experimental Therapeutics. PMID 36153006 DOI: 10.1124/jpet.122.001192 |
0.338 |
|
| 2021 |
Hiranita T, Obeng S, Sharma A, Wilkerson JL, McCurdy CR, McMahon LR. In vitro and in vivo pharmacology of kratom. Advances in Pharmacology (San Diego, Calif.). 93: 35-76. PMID 35341571 DOI: 10.1016/bs.apha.2021.10.001 |
0.32 |
|
| 2021 |
León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, ... ... McCurdy CR, et al. Activity of ("Kratom") Alkaloids at Serotonin Receptors. Journal of Medicinal Chemistry. PMID 34467758 DOI: 10.1021/acs.jmedchem.1c00726 |
0.34 |
|
| 2021 |
Liu CZ, Mottinelli M, Nicholson HE, McVeigh BM, Wong NK, McCurdy CR, Bowen WD. Identification and characterization of MAM03055A: a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity. European Journal of Pharmacology. 174263. PMID 34144027 DOI: 10.1016/j.ejphar.2021.174263 |
0.334 |
|
| 2021 |
Chear NJ, León F, Sharma A, Kanumuri SRR, Zwolinski G, Abboud KA, Singh D, Restrepo LF, Patel A, Hiranita T, Ramanathan S, Hampson AJ, McMahon LR, McCurdy CR. Exploring the Chemistry of Alkaloids from Malaysian (Kratom) and the Role of Oxindoles on Human Opioid Receptors. Journal of Natural Products. PMID 33635670 DOI: 10.1021/acs.jnatprod.0c01055 |
0.321 |
|
| 2020 |
Popa R, Kamble SH, Kanumuri RS, King TI, Berthold EC, Intagliata S, Sharma A, McCurdy CR. Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand. Journal of Pharmaceutical and Biomedical Analysis. 191: 113610. PMID 32971495 DOI: 10.1016/J.Jpba.2020.113610 |
0.358 |
|
| 2020 |
Behnood-Rod A, Chellian R, Wilson R, Hiranita T, Sharma A, Leon F, McCurdy CR, McMahon LR, Bruijnzeel AW. Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats. Drug and Alcohol Dependence. 215: 108235. PMID 32889450 DOI: 10.1016/J.Drugalcdep.2020.108235 |
0.386 |
|
| 2020 |
Maxwell EA, King TI, Kamble SH, Raju KSR, Berthold EC, León F, Avery BA, McMahon LR, McCurdy CR, Sharma A. Pharmacokinetics and Safety of Mitragynine in Beagle Dogs. Planta Medica. PMID 32693425 DOI: 10.1055/A-1212-5475 |
0.323 |
|
| 2020 |
Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/S12248-020-00472-X |
0.442 |
|
| 2020 |
McVeigh BM, Oakes AK, Liu CZ, Mesangeau C, Alsharif WF, McCurdy CR, Bowen WD. Abstract 2559: Pharmacological characterization of sigma-2 receptor ligand-induced metabolic stimulation in human SK-N-SH neuroblastoma cells Cancer Research. 80: 2559-2559. DOI: 10.1158/1538-7445.Am2020-2559 |
0.389 |
|
| 2020 |
Patel A, Obeng S, Burns M, Intagliata S, Mottinelli M, Reeves ME, Behnke M, Restrepo LF, Taylor VA, Pennington AE, Gamez Jimenez LR, Williamson MR, McCurdy CR, McMahon LR, Hiranita T. The Sigma
1
Receptor Antagonist CM304 Enhances the Antinociceptive Effects of the Cannabinoid Receptor Agonists, but not Mu‐Opioid Receptor Full Agonists in Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05719 |
0.415 |
|
| 2020 |
Obeng S, Patel A, Burns M, Intagliata S, Mottinelli M, Reeves ME, Behnke M, Restrepo LF, Ho NP, Gamez Jimenez LR, Williamson MR, McCurdy CR, McMahon LR, Hiranita T. The Sigma
1
Receptor Antagonist CM304 Potentiates the Antinociceptive but not the Discriminative Stimulus Effects of the Cannabinoid Receptor Agonist THC in Rats The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05381 |
0.405 |
|
| 2020 |
Intagliata S, Agha H, Kopajtic TA, Katz JL, Kamble SH, Sharma A, Avery BA, McCurdy CR. Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands Medicinal Chemistry Research. 29: 1697-1706. DOI: 10.1007/S00044-020-02597-2 |
0.319 |
|
| 2019 |
Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear N, Ramanathan S, Sharma A, Leon F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Investigation of the Adrenergic and Opioid Binding affinities, Metabolic Stability, Plasma Protein Binding Properties and Functional Effects of Selected Indole-based Kratom Alkaloids. Journal of Medicinal Chemistry. PMID 31834797 DOI: 10.1021/Acs.Jmedchem.9B01465 |
0.421 |
|
| 2019 |
Singh D, Yeou Chear NJ, Narayanan S, Leon F, Sharma A, McCurdy CR, Avery BA, Balasingam V. Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users. Journal of Ethnopharmacology. 112462. PMID 31816368 DOI: 10.1016/J.Jep.2019.112462 |
0.326 |
|
| 2019 |
King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, Kamble SH, McCurdy CR, Avery BA. Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1134: 121875. PMID 31790916 DOI: 10.1016/J.Jchromb.2019.121875 |
0.33 |
|
| 2019 |
Cirino TJ, Eans SO, Medina JM, Wilson LL, Mottinelli M, Intagliata S, McCurdy CR, McLaughlin JP. Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain. Frontiers in Pharmacology. 10: 678. PMID 31258480 DOI: 10.3389/Fphar.2019.00678 |
0.378 |
|
| 2019 |
Prozialeck WC, Avery BA, Boyer EW, Grundmann O, Henningfield JE, Kruegel AC, McMahon LR, McCurdy CR, Swogger MT, Veltri CA, Singh D. Kratom policy: The challenge of balancing therapeutic potential with public safety. The International Journal On Drug Policy. 70: 70-77. PMID 31103778 DOI: 10.1016/J.Drugpo.2019.05.003 |
0.329 |
|
| 2019 |
Hiranita T, Leon F, Felix JS, Restrepo LF, Reeves ME, Pennington AE, Obeng S, Avery BA, McCurdy CR, McMahon LR, Wilkerson JL. The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats. Psychopharmacology. PMID 31098655 DOI: 10.1007/S00213-019-05247-7 |
0.402 |
|
| 2019 |
Intagliata S, Alsharif WF, Mesangeau C, Fazio N, Seminerio M, Xu YT, Matsumoto RR, McCurdy CR. Benzimidazolone-based selective σ receptor ligands: Synthesis and pharmacological evaluation. European Journal of Medicinal Chemistry. 165: 250-257. PMID 30685525 DOI: 10.1016/J.Ejmech.2019.01.019 |
0.439 |
|
| 2019 |
Liu CZ, McVeigh BM, Mottinelli M, Nicholson HE, McCurdy CR, Bowen WD. Abstract 1294: Differential sigma-2 receptor-mediated metabolic stimulative and apoptotic effects of monovalent CM571 and its homo-bivalent counterpart, MAM03055A Cancer Research. 79: 1294-1294. DOI: 10.1158/1538-7445.Am2019-1294 |
0.425 |
|
| 2018 |
Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD. Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-activity Relationships of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives. The Journal of Pharmacology and Experimental Therapeutics. PMID 30530624 DOI: 10.1124/jpet.118.253484 |
0.331 |
|
| 2018 |
Cipriano PW, Lee SW, Yoon D, Shen B, Tawfik VL, Curtin CM, Dragoo JL, James ML, McCurdy CR, Chin FT, Biswal S. Successful treatment of chronic knee pain following localization by a sigma-1 receptor radioligand and PET/MRI: a case report. Journal of Pain Research. 11: 2353-2357. PMID 30349360 DOI: 10.2147/Jpr.S167839 |
0.302 |
|
| 2018 |
Pandey P, Roy KK, Liu H, Ma G, Pettaway S, Alsharif WF, Gadepalli RS, Rimoldi JM, McCurdy CR, Cutler SJ, Doerksen RJ. Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists. Molecules (Basel, Switzerland). 23. PMID 30322136 DOI: 10.3390/Molecules23102630 |
0.409 |
|
| 2018 |
Hemby SE, McIntosh S, Leon F, Cutler SJ, McCurdy CR. Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine. Addiction Biology. PMID 29949228 DOI: 10.1111/Adb.12639 |
0.353 |
|
| 2017 |
Liu X, Fu Y, Yang H, Mavlyutov T, Li J, McCurdy CR, Guo LW, Pattnaik BR. Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel. Oncotarget. 8: 59345-59358. PMID 28938641 DOI: 10.18632/Oncotarget.19581 |
0.346 |
|
| 2017 |
Townsend EA, Naylor JE, Negus SS, Edwards SR, Qureshi HN, McLendon HW, McCurdy CR, Kapanda CN, do Carmo JM, da Silva FS, Hall JE, Sufka KJ, Freeman KB. Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats. Psychopharmacology. PMID 28567699 DOI: 10.1007/S00213-017-4652-3 |
0.362 |
|
| 2017 |
Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL. The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. The Journal of Biological Chemistry. PMID 28495886 DOI: 10.1074/Jbc.M116.774075 |
0.356 |
|
| 2017 |
Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR. A Role for Sigma Receptors in Stimulant Self-Administration and Addiction. Handbook of Experimental Pharmacology. PMID 28110353 DOI: 10.1007/164_2016_94 |
0.341 |
|
| 2016 |
Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR. Blockade of Cocaine or Sigma Receptor Agonist Self-Administration by Subtype- Selective Sigma Receptor Antagonists. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189970 DOI: 10.1124/Jpet.116.232728 |
0.603 |
|
| 2016 |
Nicholson HE, Alsharif W, McCurdy CR, Bowen WD. Abstract 3804: Structural changes to SN79 result in ligands that stimulate a metabolic function of sigma-2 receptors Cancer Research. 76: 3804-3804. DOI: 10.1158/1538-7445.Am2016-3804 |
0.387 |
|
| 2015 |
Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Ebiomedicine. 2: 1806-13. PMID 26870805 DOI: 10.1016/J.Ebiom.2015.10.017 |
0.384 |
|
| 2015 |
Nicholson H, Mesangeau C, McCurdy CR, Bowen WD. Sigma-2 receptors play a role in cellular metabolism: Stimulation of glycolytic hallmarks by CM764 in human SK-N-SH neuroblastoma. The Journal of Pharmacology and Experimental Therapeutics. PMID 26574517 DOI: 10.1124/Jpet.115.228387 |
0.377 |
|
| 2015 |
Kumarihamy M, León F, Pettaway S, Wilson L, Lambert JA, Wang M, Hill C, McCurdy CR, ElSohly MA, Cutler SJ, Muhammad I. In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower. Journal of Ethnopharmacology. JEPD1501341. PMID 26260436 DOI: 10.1016/J.Jep.2015.08.006 |
0.341 |
|
| 2015 |
Nicholson H, Comeau A, Mesangeau C, McCurdy CR, Bowen WD. Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. The Journal of Pharmacology and Experimental Therapeutics. 354: 203-12. PMID 26034081 DOI: 10.1124/Jpet.115.224105 |
0.383 |
|
| 2015 |
Abdelazeem AH, Khan SI, White SW, Sufka KJ, McCurdy CR. Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents. Bioorganic & Medicinal Chemistry. 23: 3248-59. PMID 25975638 DOI: 10.1016/J.Bmc.2015.04.057 |
0.308 |
|
| 2015 |
Nicholson HE, Alsharif W, McCurdy CR, Bowen WD. Abstract 2440: Evaluation of structural changes in SN79-derived sigma-2 receptor modulators: effect on apoptotic efficacy in SK-N-SH neuroblastoma Cancer Research. 75: 2440-2440. DOI: 10.1158/1538-7445.Am2015-2440 |
0.447 |
|
| 2015 |
Kumarihamy M, Leon F, Pettaway S, Lambert J, Hill C, Wang M, Wilson L, McCurdy C, ElSohly M, Cutler S, Muhammad I. In vitro opioid receptor displacement affinity and in vitro behavioral studies by tetrad assay of Nelumbo nucifera flower Planta Medica. 81. DOI: 10.1055/S-0035-1556526 |
0.415 |
|
| 2014 |
Husni AS, McCurdy CR, Radwan MM, Ahmed SA, Slade D, Ross SA, ElSohly MA, Cutler SJ. Evaluation of Phytocannabinoids from High Potency Cannabis sativa using In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 23: 4295-4300. PMID 25419092 DOI: 10.1007/S00044-014-0972-6 |
0.449 |
|
| 2014 |
Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR. Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. Journal of Medicinal Chemistry. 57: 8903-27. PMID 25268943 DOI: 10.1021/Jm500989N |
0.36 |
|
| 2014 |
Abdelazeem AH, Abdelatef SA, El-Saadi MT, Omar HA, Khan SI, McCurdy CR, El-Moghazy SM. Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 62: 197-211. PMID 24907682 DOI: 10.1016/J.Ejps.2014.05.025 |
0.305 |
|
| 2014 |
Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR. SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation. Experimental Neurology. 254: 180-9. PMID 24508558 DOI: 10.1016/J.Expneurol.2014.01.020 |
0.391 |
|
| 2014 |
Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR. Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro. European Journal of Pharmacology. 724: 193-203. PMID 24380829 DOI: 10.1016/J.Ejphar.2013.12.039 |
0.347 |
|
| 2014 |
Nicholson HE, Chia PL, Comeau A, Mesangeau C, McCurdy C, Bowen WD. Abstract 3237: Characterization of CM-572 and CM-769: Novel irreversible modulators of sigma-2 receptor function Cancer Research. 74: 3237-3237. DOI: 10.1158/1538-7445.Am2014-3237 |
0.383 |
|
| 2013 |
Bhat R, Fishback JA, Matsumoto RR, Poupaert JH, McCurdy CR. Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands. Bioorganic & Medicinal Chemistry Letters. 23: 5011-3. PMID 23867168 DOI: 10.1016/J.Bmcl.2013.06.032 |
0.67 |
|
| 2013 |
Robson MJ, Seminerio MJ, McCurdy CR, Coop A, Matsumoto RR. σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation. Pharmacological Reports : Pr. 65: 343-9. PMID 23744418 DOI: 10.1016/S1734-1140(13)71009-0 |
0.409 |
|
| 2013 |
Robson MJ, Turner RC, Naser ZJ, McCurdy CR, Huber JD, Matsumoto RR. SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation. Experimental Neurology. 247: 134-42. PMID 23631864 DOI: 10.1016/J.Expneurol.2013.04.009 |
0.361 |
|
| 2013 |
Giacometti RD, Duchek J, Werner L, Husni AS, McCurdy CR, Cutler SJ, Cox DP, Hudlicky T. Heteroatom analogues of hydrocodone: synthesis and biological activity. The Journal of Organic Chemistry. 78: 2914-25. PMID 23397939 DOI: 10.1021/Jo3026753 |
0.35 |
|
| 2013 |
Seminerio MJ, Hansen R, Kaushal N, Zhang HT, McCurdy CR, Matsumoto RR. The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1033-44. PMID 22932447 DOI: 10.1017/S1461145712000831 |
0.37 |
|
| 2013 |
Kaushal N, Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR. Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 960-71. PMID 22921523 DOI: 10.1016/J.Euroneuro.2012.08.005 |
0.447 |
|
| 2013 |
Nicholson H, Comeau A, Mesangeau C, McCurdy CR, Bowen WD. Abstract 2242: Development of selective irreversible antagonists for sigma-2 receptors. Cancer Research. 73: 2242-2242. DOI: 10.1158/1538-7445.Am2013-2242 |
0.427 |
|
| 2012 |
Fishback JA, Rosen A, Bhat R, McCurdy CR, Matsumoto RR. A 96-well filtration method for radioligand binding analysis of σ receptor ligands. Journal of Pharmaceutical and Biomedical Analysis. 71: 157-61. PMID 22910107 DOI: 10.1016/J.Jpba.2012.07.023 |
0.659 |
|
| 2012 |
Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR. Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus. European Journal of Pharmacology. 691: 103-9. PMID 22820108 DOI: 10.1016/J.Ejphar.2012.07.029 |
0.325 |
|
| 2012 |
Mankus JV, McCurdy CR. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Medicinal Chemistry. 4: 1085-92. PMID 22709252 DOI: 10.4155/Fmc.12.67 |
0.718 |
|
| 2012 |
Nieto MJ, Pierini AB, Singh N, McCurdy CR, Manzo RH, Mazzieri MR. SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 8: 349-60. PMID 22530906 DOI: 10.2174/157340612800786633 |
0.509 |
|
| 2012 |
Xu YT, Robson MJ, Szeszel-Fedorowicz W, Patel D, Rooney R, McCurdy CR, Matsumoto RR. CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain. Pharmacology, Biochemistry, and Behavior. 101: 174-80. PMID 22234290 DOI: 10.1016/J.Pbb.2011.12.016 |
0.34 |
|
| 2012 |
Seminerio MJ, Robson MJ, Abdelazeem AH, Mesangeau C, Jamalapuram S, Avery BA, McCurdy CR, Matsumoto RR. Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine. The Aaps Journal. 14: 43-51. PMID 22183188 DOI: 10.1208/S12248-011-9311-8 |
0.424 |
|
| 2012 |
Dale O, Ma G, Gemelli C, Husni A, McCurdy C, Avery B, Leon J, Furr E, Manly S, Cutler S. Effects of Mitragynine and its Derivatives on Human Opioid Receptors (Delta, Kappa, and Mu) Planta Medica. 78. DOI: 10.1055/S-0032-1307599 |
0.402 |
|
| 2011 |
Ward J, Rosenbaum C, Hernon C, McCurdy CR, Boyer EW. Herbal medicines for the management of opioid addiction: safe and effective alternatives to conventional pharmacotherapy? Cns Drugs. 25: 999-1007. PMID 22133323 DOI: 10.2165/11596830-000000000-00000 |
0.315 |
|
| 2011 |
Mésangeau C, Amata E, Alsharif W, Seminerio MJ, Robson MJ, Matsumoto RR, Poupaert JH, McCurdy CR. Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. European Journal of Medicinal Chemistry. 46: 5154-61. PMID 21899931 DOI: 10.1016/J.Ejmech.2011.08.031 |
0.444 |
|
| 2011 |
Kaushal N, Seminerio MJ, Shaikh J, Medina MA, Mesangeau C, Wilson LL, McCurdy CR, Matsumoto RR. CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice. Neuropharmacology. 61: 992-1000. PMID 21762711 DOI: 10.1016/J.Neuropharm.2011.06.028 |
0.4 |
|
| 2011 |
Kaushal N, Robson MJ, Vinnakota H, Narayanan S, Avery BA, McCurdy CR, Matsumoto RR. Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents. The Aaps Journal. 13: 336-46. PMID 21494909 DOI: 10.1208/S12248-011-9274-9 |
0.6 |
|
| 2011 |
Narayanan S, Bhat R, Mesangeau C, Poupaert JH, McCurdy CR. Early development of sigma-receptor ligands. Future Medicinal Chemistry. 3: 79-94. PMID 21428827 DOI: 10.4155/Fmc.10.279 |
0.742 |
|
| 2011 |
Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS. N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers. Proceedings of the National Academy of Sciences of the United States of America. 108: 5098-103. PMID 21385944 DOI: 10.1073/Pnas.1016277108 |
0.348 |
|
| 2011 |
Fishback JA, Mesangeau C, Poupaert JH, McCurdy CR, Matsumoto RR. Synthesis and characterization of [³H]-SN56, a novel radioligand for the σ₁ receptor. European Journal of Pharmacology. 653: 1-7. PMID 21130085 DOI: 10.1016/J.Ejphar.2010.10.099 |
0.387 |
|
| 2011 |
Narayanan S, Mesangeau C, Poupaert JH, McCurdy CR. Sigma receptors and cocaine abuse. Current Topics in Medicinal Chemistry. 11: 1128-50. PMID 21050176 DOI: 10.2174/156802611795371323 |
0.612 |
|
| 2011 |
Adkins JE, Boyer EW, McCurdy CR. Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. Current Topics in Medicinal Chemistry. 11: 1165-75. PMID 21050173 DOI: 10.2174/156802611795371305 |
0.714 |
|
| 2011 |
Garcés-RamÃrez L, Green JL, Hiranita T, Kopajtic TA, Mereu M, Thomas AM, Mesangeau C, Narayanan S, McCurdy CR, Katz JL, Tanda G. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biological Psychiatry. 69: 208-17. PMID 20950794 DOI: 10.1016/J.Biopsych.2010.07.026 |
0.637 |
|
| 2010 |
Xu YT, Kaushal N, Shaikh J, Wilson LL, Mésangeau C, McCurdy CR, Matsumoto RR. A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice. The Journal of Pharmacology and Experimental Therapeutics. 333: 491-500. PMID 20100904 DOI: 10.1124/Jpet.109.161398 |
0.381 |
|
| 2010 |
James ML, Shen B, Zavaleta C, Berganos RA, Mesangeau C, Shaikh J, Gambhir SS, Matsumoto RR, McCurdy CR, Chin FT. [18F]FTC-146: A novel and highly selective PET ligand for visualizing sigma-1 receptors in living subjects Neuroimage. 52: S123-S124. DOI: 10.1016/J.Neuroimage.2010.04.101 |
0.31 |
|
| 2009 |
Nolan T, Singh N, McCurdy CR. Ligand macromolecule interactions: theoretical principles of molecular recognition. Methods in Molecular Biology (Clifton, N.J.). 572: 13-29. PMID 20694683 DOI: 10.1007/978-1-60761-244-5_2 |
0.5 |
|
| 2009 |
León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ. Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A. Natural Product Communications. 4: 907-10. PMID 19731590 |
0.678 |
|
| 2009 |
Dayan FE, Singh N, McCurdy CR, Godfrey CA, Larsen L, Weavers RT, Van Klink JW, Perry NB. Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions. Journal of Agricultural and Food Chemistry. 57: 5194-200. PMID 19435355 DOI: 10.1021/Jf9005593 |
0.522 |
|
| 2009 |
León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ. Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A. Natural Product Communications. 4: 907-910. DOI: 10.1177/1934578X0900400705 |
0.695 |
|
| 2008 |
Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction (Abingdon, England). 103: 1048-50. PMID 18482427 DOI: 10.1111/J.1360-0443.2008.02209.X |
0.698 |
|
| 2008 |
Singh N, Nolan TL, McCurdy CR. Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists. Journal of Molecular Graphics & Modelling. 27: 131-9. PMID 18456526 DOI: 10.1016/J.Jmgm.2008.03.007 |
0.585 |
|
| 2008 |
Kane BE, McCurdy CR, Ferguson DM. Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. Journal of Medicinal Chemistry. 51: 1824-30. PMID 18293909 DOI: 10.1021/Jm701040V |
0.407 |
|
| 2008 |
Mésangeau C, Narayanan S, Green AM, Shaikh J, Kaushal N, Viard E, Xu YT, Fishback JA, Poupaert JH, Matsumoto RR, McCurdy CR. Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. Journal of Medicinal Chemistry. 51: 1482-6. PMID 18278854 DOI: 10.1021/Jm701357M |
0.65 |
|
| 2008 |
Babu KM, McCurdy CR, Boyer EW. Opioid receptors and legal highs: Salvia divinorum and Kratom. Clinical Toxicology (Philadelphia, Pa.). 46: 146-52. PMID 18259963 DOI: 10.1080/15563650701241795 |
0.418 |
|
| 2008 |
Fishback jA, Mesangeau C, Narayanan S, McCurdy CR, Matsumoto RR. Novel Radioligands for Sigma‐1 Receptor Binding Studies The Faseb Journal. 22: 628-628. DOI: 10.1096/Fasebj.22.2_Supplement.628 |
0.618 |
|
| 2007 |
Singh N, Avery MA, McCurdy CR. Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations. Journal of Computer-Aided Molecular Design. 21: 511-22. PMID 17874041 DOI: 10.1007/S10822-007-9132-0 |
0.496 |
|
| 2007 |
Willmore-Fordham CB, Krall DM, McCurdy CR, Kinder DH. The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats. Neuropharmacology. 53: 481-6. PMID 17681558 DOI: 10.1016/J.Neuropharm.2007.06.008 |
0.408 |
|
| 2007 |
Singh N, Chevé G, Avery MA, McCurdy CR. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme. Current Pharmaceutical Design. 13: 1161-77. PMID 17430177 DOI: 10.2174/138161207780618939 |
0.474 |
|
| 2007 |
Dayan FE, Duke SO, Sauldubois A, Singh N, McCurdy C, Cantrell C. p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium. Phytochemistry. 68: 2004-14. PMID 17368492 DOI: 10.1016/J.Phytochem.2007.01.026 |
0.49 |
|
| 2007 |
Philip AE, Poupaert JH, Chevé G, Muccioli G, Lambert D, McCurdy CR. Structure-activity relationship of phenytoinergic antiepileptic drugs related to ameltolide Medicinal Chemistry Research. 16: 130-135. DOI: 10.1007/S00044-007-9016-9 |
0.609 |
|
| 2006 |
Singh N, Chevé G, Ferguson DM, McCurdy CR. A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist. Journal of Computer-Aided Molecular Design. 20: 471-93. PMID 17009091 DOI: 10.1007/S10822-006-9067-X |
0.579 |
|
| 2006 |
Singh N, Chevé G, Avery MA, McCurdy CR. Comparative protein modeling of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme from Plasmodium falciparum: a potential target for antimalarial drug discovery. Journal of Chemical Information and Modeling. 46: 1360-70. PMID 16711755 DOI: 10.1021/Ci050523W |
0.409 |
|
| 2006 |
Kane BE, Nieto MJ, McCurdy CR, Ferguson DM. A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist. The Febs Journal. 273: 1966-74. PMID 16640560 DOI: 10.1111/J.1742-4658.2006.05212.X |
0.427 |
|
| 2006 |
Vyas N, Mollereau C, Chevé G, McCurdy CR. Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives. Peptides. 27: 990-6. PMID 16490282 DOI: 10.1016/J.Peptides.2005.07.024 |
0.393 |
|
| 2006 |
McCurdy CR, Sufka KJ, Smith GH, Warnick JE, Nieto MJ. Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist. Pharmacology, Biochemistry, and Behavior. 83: 109-13. PMID 16434091 DOI: 10.1016/J.Pbb.2005.12.011 |
0.38 |
|
| 2006 |
McCurdy CR. Development of Opioid Receptor Ligands Analogue-Based Drug Discovery. 259-276. DOI: 10.1002/3527608001.ch14 |
0.312 |
|
| 2005 |
McCurdy CR, Scully SS. Analgesic substances derived from natural products (natureceuticals). Life Sciences. 78: 476-84. PMID 16216276 DOI: 10.1016/J.Lfs.2005.09.006 |
0.325 |
|
| 2005 |
Geldenhuys WJ, Lockman PR, Philip AE, McAfee JH, Miller BL, McCurdy CR, Allen DD. Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier. Journal of Drug Targeting. 13: 259-66. PMID 16051538 DOI: 10.1080/10611860500139222 |
0.617 |
|
| 2005 |
Warnick JE, McCurdy CR, Sufka KJ. Opioid receptor function in social attachment in young domestic fowl. Behavioural Brain Research. 160: 277-85. PMID 15863224 DOI: 10.1016/J.Bbr.2004.12.009 |
0.406 |
|
| 2005 |
Philip AE, Poupaert JH, McCurdy CR. Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity. Current Topics in Medicinal Chemistry. 5: 325-40. PMID 15857315 DOI: 10.2174/1568026053544489 |
0.702 |
|
| 2005 |
Nieto MJ, Philip AE, Poupaert JH, McCurdy CR. Solution-phase parallel synthesis of spirohydantoins. Journal of Combinatorial Chemistry. 7: 258-63. PMID 15762754 DOI: 10.1021/Cc049870T |
0.574 |
|
| 2005 |
Yous S, Wallez V, Belloir M, Caignard DH, McCurdy CR, Poupaert JH. Novel 2(3H)-benzothiazolones as highly potent and selective sigma-1 receptor ligands Medicinal Chemistry Research. 14: 158-168. DOI: 10.1007/S00044-005-0131-1 |
0.368 |
|
| 2002 |
McCurdy CR, Le Bourdonnec B, Metzger TG, El Kouhen R, Zhang Y, Law PY, Portoghese PS. Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties. Journal of Medicinal Chemistry. 45: 2887-90. PMID 12086475 DOI: 10.1021/Jm015586U |
0.312 |
|
| 1999 |
McCurdy CR, Venkateshwaran TG, Beach JW, Stewart JT. Chiral separation of lobeline analogs using high performance capillary electrophoresis and derivatized cyclodextrins as chiral additives. Electrophoresis. 20: 212-8. PMID 10065979 DOI: 10.1002/(SICI)1522-2683(19990101)20:1<212::AID-ELPS212>3.0.CO;2-M |
0.598 |
|
| 1998 |
Metting TL, Burgio DE, Terry AV, Beach JW, McCurdy CR, Allen DD. Inhibition of brain choline uptake by isoarecolone and lobeline derivatives: Implications for potential vector-mediated brain drug delivery Neuroscience Letters. 258: 25-28. PMID 9876043 DOI: 10.1016/S0304-3940(98)00871-4 |
0.602 |
|
| 1998 |
Terry AV, Williamson R, Gattu M, Beach JW, McCurdy CR, Sparks JA, Pauly JR. Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine. Neuropharmacology. 37: 93-102. PMID 9680262 DOI: 10.1016/S0028-3908(97)00142-1 |
0.643 |
|
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