| Year |
Citation |
Score |
| 2020 |
Bhat SA, Sarwar Z, Gillani Q, Un Nisa M, Reshi I, Nabi N, Xie S, Fazili KM, Roberts TM, Andrabi S. Polyoma Small T antigen Induces Apoptosis In Mammalian Cells Through UNC5B Pathway In A PP2A Dependent Manner. Journal of Virology. PMID 32404521 DOI: 10.1128/Jvi.02187-19 |
0.337 |
|
| 2019 |
Sun B, Mason S, Wilson RC, Hazard SE, Wang Y, Fang R, Wang Q, Yeh ES, Yang M, Roberts TM, Zhao JJ, Wang Q. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. PMID 31462705 DOI: 10.1038/S41388-019-0953-9 |
0.318 |
|
| 2018 |
Wang Y, Li BB, Li J, Roberts TM, Zhao JJ. A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells. Iscience. 9: 149-160. PMID 30391850 DOI: 10.1016/J.Isci.2018.10.015 |
0.33 |
|
| 2018 |
Sun B, Wang G, Liu H, Liu P, Twal WO, Cheung H, Carroll SL, Ethier SP, Mevers EE, Clardy J, Roberts T, Chen C, Li Q, Wang L, Yang M, et al. Oridonin inhibits aberrant AKT activation in breast cancer. Oncotarget. 9: 23878-23889. PMID 29844859 DOI: 10.18632/Oncotarget.24378 |
0.341 |
|
| 2018 |
Hemmati S, Sinclair T, Tong M, Bartholdy B, Okabe R, Ames K, Ostrodka L, Haque T, Kaur I, Agarwal A, Zhao J, Roberts T, Gritsman K. PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress Blood. 132: 329-329. DOI: 10.1182/Blood-2018-99-114891 |
0.312 |
|
| 2017 |
Bian X, Gao J, Luo F, Rui C, Zheng T, Wang D, Wang Y, Roberts TM, Liu P, Zhao JJ, Cheng H. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. PMID 28945226 DOI: 10.1038/Onc.2017.326 |
0.307 |
|
| 2017 |
Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, ... ... Roberts TM, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. PMID 28813415 DOI: 10.1038/Nature23465 |
0.323 |
|
| 2017 |
Zhang J, Gao X, Schmit F, Adelmant G, Eck MJ, Marto JA, Zhao JJ, Roberts TM. CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. Cell Reports. 20: 549-557. PMID 28723560 DOI: 10.1016/J.Celrep.2017.06.054 |
0.388 |
|
| 2017 |
Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, et al. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. PMID 28607489 DOI: 10.1038/Nature22797 |
0.323 |
|
| 2017 |
Spangle JM, Roberts TM, Zhao JJ. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochimica Et Biophysica Acta. PMID 28315368 DOI: 10.1016/J.Bbcan.2017.03.002 |
0.307 |
|
| 2016 |
Cizmecioglu O, Ni J, Xie S, Zhao JJ, Roberts TM. Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss. Elife. 5. PMID 27700986 DOI: 10.7554/Elife.17635 |
0.389 |
|
| 2016 |
Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discovery. 2: 16030. PMID 27672444 DOI: 10.1038/Celldisc.2016.30 |
0.356 |
|
| 2016 |
Spangle JM, Dreijerink KM, Groner AC, Cheng H, Ohlson CE, Reyes J, Lin CY, Bradner J, Zhao JJ, Roberts TM, Brown M. PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. Cell Reports. PMID 27292631 DOI: 10.1016/J.Celrep.2016.05.046 |
0.309 |
|
| 2016 |
Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. Transformation by Polyomavirus Middle T Antigen Involves A Unique Bimodal Interaction with the Hippo Effector YAP. Journal of Virology. PMID 27194756 DOI: 10.1128/Jvi.00417-16 |
0.332 |
|
| 2016 |
Cizmecioglu O, Ni J, Xie S, Zhao JJ, Roberts TM. Author response: Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss Elife. DOI: 10.7554/Elife.17635.017 |
0.305 |
|
| 2015 |
Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM. Correction for hwang et Al., polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 89: 6971. PMID 26041839 DOI: 10.1128/Jvi.00952-15 |
0.306 |
|
| 2015 |
Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM. Polyoma small T antigen triggers cell death via mitotic catastrophe. Oncogene. 34: 2483-92. PMID 24998850 DOI: 10.1038/Onc.2014.192 |
0.358 |
|
| 2014 |
Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Current Biology : Cb. 24: 2274-80. PMID 25220053 DOI: 10.1016/J.Cub.2014.08.007 |
0.301 |
|
| 2014 |
Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 88: 12055-64. PMID 25122798 DOI: 10.1128/Jvi.01399-14 |
0.386 |
|
| 2014 |
Utermark T, Schmit F, Lee SH, Gao X, Schaffhausen BS, Roberts TM. The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type. Journal of Virology. 88: 10673-9. PMID 24991009 DOI: 10.1128/Jvi.01409-14 |
0.307 |
|
| 2014 |
Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158: 171-84. PMID 24954536 DOI: 10.1016/J.Cell.2014.06.004 |
0.314 |
|
| 2014 |
Schmit F, Utermark T, Zhang S, Wang Q, Von T, Roberts TM, Zhao JJ. PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proceedings of the National Academy of Sciences of the United States of America. 111: 6395-400. PMID 24737887 DOI: 10.1073/Pnas.1323004111 |
0.307 |
|
| 2012 |
Utermark T, Rao T, Cheng H, Wang Q, Lee SH, Wang ZC, Iglehart JD, Roberts TM, Muller WJ, Zhao JJ. The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes & Development. 26: 1573-86. PMID 22802530 DOI: 10.1101/Gad.191973.112 |
0.32 |
|
| 2012 |
Roberts TM, Stewart M. Role of major sperm protein (MSP) in the protrusion and retraction of Ascaris sperm. International Review of Cell and Molecular Biology. 297: 265-93. PMID 22608562 DOI: 10.1016/B978-0-12-394308-8.00007-8 |
0.417 |
|
| 2012 |
Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discovery. 2: 425-33. PMID 22588880 DOI: 10.1158/2159-8290.Cd-12-0003 |
0.325 |
|
| 2012 |
Gritsman K, Clayton L, Gilliland DG, Roberts TM, Zhao J. The p110alpha and p110delta Isoforms of PI3 Kinase Are Dispensable for Hematopoietic Stem Cell Self-Renewal but Have Redundant Roles in B Cell Differentiation. Blood. 120: 2322-2322. DOI: 10.1182/Blood.V120.21.2322.2322 |
0.317 |
|
| 2012 |
Malowney AJ, Stewart M, Roberts TM. Electron Tomography of MSP Filaments Derived from the Amoeboid Sperm of Ascaris Suum Biophysical Journal. 102: 696a. DOI: 10.1016/J.Bpj.2011.11.3777 |
0.409 |
|
| 2011 |
Shimabukuro K, Noda N, Stewart M, Roberts TM. Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction. Current Biology : Cb. 21: 1727-31. PMID 22000106 DOI: 10.1016/J.Cub.2011.08.047 |
0.409 |
|
| 2011 |
Ilic N, Utermark T, Widlund HR, Roberts TM. PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proceedings of the National Academy of Sciences of the United States of America. 108: E699-708. PMID 21876152 DOI: 10.1073/Pnas.1108237108 |
0.316 |
|
| 2011 |
Andrabi S, Hwang JH, Choe JK, Roberts TM, Schaffhausen BS. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. Journal of Virology. 85: 10649-58. PMID 21835797 DOI: 10.1128/Jvi.05034-11 |
0.343 |
|
| 2011 |
Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM. Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. Journal of Virology. 85: 5581-92. PMID 21411524 DOI: 10.1128/Jvi.02609-10 |
0.33 |
|
| 2011 |
Malowney AJ, Stewart M, Roberts TM. Cryo-Electron Microscopy, Tomography, and Single-Particle Analysis of MSP Filaments Derived from the Amoeboid Sperm of Ascaris Suum Biophysical Journal. 100: 448a. DOI: 10.1016/J.Bpj.2010.12.2641 |
0.398 |
|
| 2010 |
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, ... ... Roberts TM, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 468: 968-72. PMID 21107320 DOI: 10.1038/Nature09627 |
0.323 |
|
| 2010 |
Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, ... Roberts TM, et al. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 466: 503-7. PMID 20622853 DOI: 10.1038/Nature09261 |
0.322 |
|
| 2010 |
Ilić N, Roberts TM. Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer. Current Topics in Microbiology and Immunology. 347: 55-77. PMID 20517719 DOI: 10.1007/82_2010_63 |
0.317 |
|
| 2009 |
Yi K, Wang X, Emmett MR, Marshall AG, Stewart M, Roberts TM. Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. Molecular Biology of the Cell. 20: 3200-8. PMID 19458186 DOI: 10.1091/Mbc.E09-03-0240 |
0.448 |
|
| 2009 |
Jia S, Roberts TM, Zhao JJ. Should individual PI3 kinase isoforms be targeted in cancer? Current Opinion in Cell Biology. 21: 199-208. PMID 19200708 DOI: 10.1016/J.Ceb.2008.12.007 |
0.347 |
|
| 2009 |
Schaffhausen BS, Roberts TM. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 384: 304-16. PMID 19022468 DOI: 10.1016/J.Virol.2008.09.042 |
0.386 |
|
| 2009 |
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. Journal of Virology. 83: 117-27. PMID 18922873 DOI: 10.1128/Jvi.01515-08 |
0.307 |
|
| 2009 |
Gritsman K, Khandan T, Okabe R, Gozo M, Paktinat M, Gilliland DG, Roberts TM, Zhao JJ. The p110α Catalytic Isoform of PI3 Kinase Is Important for Erythropoiesis, but Has a Minimal Role in Hematopoietic Stem Cell Self-Renewal. Blood. 114: 3620-3620. DOI: 10.1182/Blood.V114.22.3620.3620 |
0.313 |
|
| 2009 |
Shimabukuro K, Stewart M, Roberts TM. Mechanism of MSP-based Cell Body Retraction in the Amoeboid Sperm of Nematodes Biophysical Journal. 96: 520a. DOI: 10.1016/J.Bpj.2008.12.2679 |
0.335 |
|
| 2008 |
Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. Plos One. 3: e3364. PMID 18846223 DOI: 10.1371/Journal.Pone.0003364 |
0.345 |
|
| 2008 |
Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 454: 776-9. PMID 18594509 DOI: 10.1038/Nature07091 |
0.361 |
|
| 2008 |
Miao L, Vanderlinde O, Liu J, Grant RP, Wouterse A, Shimabukuro K, Philipse A, Stewart M, Roberts TM. The role of filament-packing dynamics in powering amoeboid cell motility Proceedings of the National Academy of Sciences of the United States of America. 105: 5390-5395. PMID 18385381 DOI: 10.1073/Pnas.0708416105 |
0.401 |
|
| 2007 |
Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B. Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 104: 19011-6. PMID 18006659 DOI: 10.1073/Pnas.0706696104 |
0.359 |
|
| 2007 |
Williams GL, Roberts TM, Gjoerup OV. Bub1: escapades in a cellular world. Cell Cycle (Georgetown, Tex.). 6: 1699-704. PMID 17643075 DOI: 10.4161/Cc.6.14.4493 |
0.392 |
|
| 2007 |
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, ... ... Roberts TM, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 129: 1065-79. PMID 17574021 DOI: 10.1016/J.Cell.2007.03.052 |
0.311 |
|
| 2007 |
Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM. Surveillance mechanism linking Bub1 loss to the p53 pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 8334-9. PMID 17488820 DOI: 10.1073/Pnas.0703164104 |
0.307 |
|
| 2007 |
Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ. The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. Journal of Virology. 81: 7069-76. PMID 17442716 DOI: 10.1128/Jvi.00115-07 |
0.362 |
|
| 2007 |
Yi K, Buttery SM, Stewart M, Roberts TM. A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Molecular Biology of the Cell. 18: 1816-25. PMID 17344482 DOI: 10.1091/Mbc.E06-08-0741 |
0.819 |
|
| 2007 |
Miao L, Yi K, Mackey JM, Roberts TM. Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. Cell Motility and the Cytoskeleton. 64: 235-47. PMID 17183548 DOI: 10.1002/Cm.20177 |
0.455 |
|
| 2006 |
Zhao JJ, Roberts TM. PI3 kinases in cancer: from oncogene artifact to leading cancer target. Science's Stke : Signal Transduction Knowledge Environment. 2006: pe52. PMID 17164467 DOI: 10.1126/Stke.3652006Pe52 |
0.343 |
|
| 2006 |
Zhao JJ, Cheng H, Jia S, Wang L, Gjoerup OV, Mikami A, Roberts TM. The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proceedings of the National Academy of Sciences of the United States of America. 103: 16296-300. PMID 17060635 DOI: 10.1073/Pnas.0607899103 |
0.313 |
|
| 2006 |
Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum Journal of Biological Chemistry. 281: 23003-23012. PMID 16717086 DOI: 10.1074/Jbc.M602648200 |
0.309 |
|
| 2006 |
Liu Z, Roberts TM. Human tumor mutants in the p110alpha subunit of PI3K. Cell Cycle (Georgetown, Tex.). 5: 675-7. PMID 16627990 DOI: 10.4161/Cc.5.7.2605 |
0.332 |
|
| 2005 |
Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 18443-8. PMID 16339315 DOI: 10.1073/Pnas.0508988102 |
0.339 |
|
| 2005 |
Stewart M, Roberts TM. Cytoskeleton dynamics powers nematode sperm motility. Advances in Protein Chemistry. 71: 383-99. PMID 16230117 DOI: 10.1016/S0065-3233(04)71010-4 |
0.414 |
|
| 2005 |
Qa'dan M, Christensen KA, Zhang L, Roberts TM, Collier RJ. Membrane insertion by anthrax protective antigen in cultured cells. Molecular and Cellular Biology. 25: 5492-8. PMID 15964805 DOI: 10.1128/Mcb.25.13.5492-5498.2005 |
0.301 |
|
| 2005 |
Grant RP, Buttery SM, Ekman GC, Roberts TM, Stewart M. Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. Journal of Molecular Biology. 347: 583-95. PMID 15755452 DOI: 10.1016/J.Jmb.2005.01.054 |
0.807 |
|
| 2005 |
Roberts TM. Major sperm protein. Current Biology : Cb. 15: R153. PMID 15753021 DOI: 10.1016/J.Cub.2005.02.036 |
0.49 |
|
| 2005 |
Rodriguez MA, LeClaire LL, Roberts TM. Preparing to move: assembly of the MSP amoeboid motility apparatus during spermiogenesis in Ascaris. Cell Motility and the Cytoskeleton. 60: 191-9. PMID 15751099 DOI: 10.1002/Cm.20058 |
0.798 |
|
| 2005 |
Wolgemuth CW, Miao L, Vanderlinde O, Roberts T, Oster G. MSP dynamics drives nematode sperm locomotion. Biophysical Journal. 88: 2462-71. PMID 15665134 DOI: 10.1529/Biophysj.104.054270 |
0.34 |
|
| 2004 |
Zhang L, Gjoerup O, Roberts TM. The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 101: 10296-301. PMID 15240878 DOI: 10.1073/Pnas.0403175101 |
0.343 |
|
| 2004 |
Cotsiki M, Lock RL, Cheng Y, Williams GL, Zhao J, Perera D, Freire R, Entwistle A, Golemis EA, Roberts TM, Jat PS, Gjoerup OV. Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proceedings of the National Academy of Sciences of the United States of America. 101: 947-52. PMID 14732683 DOI: 10.1073/Pnas.0308006100 |
0.322 |
|
| 2003 |
Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 4: 463-76. PMID 14706338 DOI: 10.1016/S1535-6108(03)00303-9 |
0.314 |
|
| 2003 |
Miao L, Vanderlinde O, Stewart M, Roberts TM. Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science (New York, N.Y.). 302: 1405-7. PMID 14631043 DOI: 10.1126/Science.1089129 |
0.403 |
|
| 2003 |
Buttery SM, Ekman GC, Seavy M, Stewart M, Roberts TM. Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion. Molecular Biology of the Cell. 14: 5082-8. PMID 14565983 DOI: 10.1091/Mbc.E03-04-0246 |
0.8 |
|
| 2003 |
Hong YK, Mikami A, Schaffhausen B, Jun T, Roberts TM. A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proceedings of the National Academy of Sciences of the United States of America. 100: 9434-9. PMID 12881485 DOI: 10.1073/Pnas.1432964100 |
0.32 |
|
| 2003 |
Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell. 3: 483-95. PMID 12781366 DOI: 10.1016/S1535-6108(03)00088-6 |
0.314 |
|
| 2003 |
LeClaire LL, Stewart M, Roberts TM. A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm. Journal of Cell Science. 116: 2655-63. PMID 12746486 DOI: 10.1242/Jcs.00469 |
0.809 |
|
| 2002 |
Baker AM, Roberts TM, Stewart M. 2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. Journal of Molecular Biology. 319: 491-9. PMID 12051923 DOI: 10.1016/S0022-2836(02)00294-2 |
0.378 |
|
| 2002 |
Luo H, Rose PE, Roberts TM, Dearolf CR. The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila. Molecular Genetics and Genomics : Mgg. 267: 57-63. PMID 11919715 DOI: 10.1007/S00438-001-0632-7 |
0.341 |
|
| 2002 |
Furman C, Short SM, Subramanian RR, Zetter BR, Roberts TM. DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. The Journal of Biological Chemistry. 277: 7962-9. PMID 11773070 DOI: 10.1074/Jbc.M109149200 |
0.428 |
|
| 2001 |
Gjoerup O, Zaveri D, Roberts TM. Induction of p53-independent apoptosis by simian virus 40 small t antigen. Journal of Virology. 75: 9142-55. PMID 11533178 DOI: 10.1128/Jvi.75.19.9142-9155.2001 |
0.342 |
|
| 2001 |
Chen J, Fujii K, Zhang L, Roberts T, Fu H. Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 98: 7783-7788. PMID 11427728 DOI: 10.1073/Pnas.141224398 |
0.382 |
|
| 2001 |
Chan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C, Fishman MC, Roberts TM. Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling. Developmental Biology. 234: 470-82. PMID 11397014 DOI: 10.1006/Dbio.2001.0281 |
0.31 |
|
| 2001 |
Grammatikakis N, Jaronczyk K, Siganou A, Vultur A, Brownell HL, Benzaquen M, Rausch C, Lapointe R, Gjoerup O, Roberts TM, Raptis L. Simian virus 40 large tumor antigen modulates the Raf signaling pathway. The Journal of Biological Chemistry. 276: 27840-5. PMID 11382757 DOI: 10.1074/Jbc.M101987200 |
0.333 |
|
| 2001 |
Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1110-6. PMID 11160381 DOI: 10.1523/Jneurosci.21-04-01110.2001 |
0.361 |
|
| 2001 |
Italiano JE, Stewart M, Roberts TM. How the assembly dynamics of the nematode major sperm protein generate amoeboid cell motility. International Review of Cytology. 202: 1-34. PMID 11061562 DOI: 10.1016/S0074-7696(01)02002-2 |
0.426 |
|
| 2000 |
Laham LE, Mukhopadhyay N, Roberts TM. The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity. Oncogene. 19: 3961-70. PMID 10962552 DOI: 10.1038/Sj.Onc.1203738 |
0.324 |
|
| 2000 |
Auger KR, Wang J, Narsimhan RP, Holcombe T, Roberts TM. Constitutive cellular expression of PI 3-kinase is distinct from transient expression. Biochemical and Biophysical Research Communications. 272: 822-9. PMID 10860837 DOI: 10.1006/Bbrc.2000.2806 |
0.364 |
|
| 2000 |
Roberts TM, Stewart M. Acting like actin. The dynamics of the nematode major sperm protein (msp) cytoskeleton indicate a push-pull mechanism for amoeboid cell motility. The Journal of Cell Biology. 149: 7-12. PMID 10747081 DOI: 10.1083/Jcb.149.1.7 |
0.398 |
|
| 2000 |
Gjoerup O, Chao H, DeCaprio JA, Roberts TM. pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. Journal of Virology. 74: 864-74. PMID 10623749 DOI: 10.1128/Jvi.74.2.864-874.2000 |
0.308 |
|
| 1999 |
Jun T, Gjoerup O, Roberts TM. Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. Science's Stke : Signal Transduction Knowledge Environment. 1999: PE1. PMID 11865188 DOI: 10.1126/Stke.1999.13.Pe1 |
0.341 |
|
| 1999 |
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. The Journal of Biological Chemistry. 274: 32274-8. PMID 10542266 DOI: 10.1074/Jbc.274.45.32274 |
0.344 |
|
| 1999 |
Alberta JA, Auger KR, Batt D, Iannarelli P, Hwang G, Elliott HL, Duke R, Roberts TM, Stiles CD. Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. The Journal of Biological Chemistry. 274: 31062-7. PMID 10521506 DOI: 10.1074/Jbc.274.43.31062 |
0.36 |
|
| 1999 |
Fabbro D, Batt D, Rose P, Schacher B, Roberts TM, Ferrari S. Homogeneous purification of human recombinant GST-Akt/PKB from Sf9 cells. Protein Expression and Purification. 17: 83-8. PMID 10497072 DOI: 10.1006/Prep.1999.1102 |
0.408 |
|
| 1999 |
Italiano JE, Stewart M, Roberts TM. Localized depolymerization of the major sperm protein cytoskeleton correlates with the forward movement of the cell body in the amoeboid movement of nematode sperm. The Journal of Cell Biology. 146: 1087-96. PMID 10477761 DOI: 10.1083/Jcb.146.5.1087 |
0.382 |
|
| 1999 |
Aksoy IA, Ramsey MJ, Fruman DA, Aksoy S, Cantley LC, Tucker JD, Roberts TM. Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Biochemical and Biophysical Research Communications. 262: 438-42. PMID 10462494 DOI: 10.1006/Bbrc.1999.1150 |
0.311 |
|
| 1999 |
Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM. Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. Molecular and Cellular Biology. 19: 4819-24. PMID 10373531 DOI: 10.1128/Mcb.19.7.4819 |
0.368 |
|
| 1999 |
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/akt pathway Proceedings of the National Academy of Sciences of the United States of America. 96: 2110-2115. PMID 10051603 DOI: 10.1073/Pnas.96.5.2110 |
0.392 |
|
| 1999 |
King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Molecular and Cellular Biology. 19: 2330-7. PMID 10022919 DOI: 10.1128/Mcb.19.3.2330 |
0.337 |
|
| 1998 |
Haaf A, LeClaire L, Roberts G, Kent HM, Roberts TM, Stewart M, Neuhaus D. Solution structure of the motile major sperm protein (MSP) of Ascaris suum - evidence for two manganese binding sites and the possible role of divalent cations in filament formation. Journal of Molecular Biology. 284: 1611-24. PMID 9878374 DOI: 10.1006/Jmbi.1998.2291 |
0.785 |
|
| 1998 |
Stewart M, Roberts TM, Italiano JE, King KL, Hammel R, Parathasathy G, Bullock TL, McCoy AJ, Kent H, Haaf A, Neuhaus D. Amoeboid motility without actin: insights into the molecular mechanism of locomotion using the major sperm protein (MSP) of nematodes. The Biological Bulletin. 194: 342-3; discussion 34. PMID 9664658 DOI: 10.2307/1543107 |
0.705 |
|
| 1998 |
Oliveira ML, Roberts TM, Druker BJ, Armelin MC. Mapping of polyomavirus middle T domain that is responsible for AP-1 activation. Oncogene. 16: 2975-82. PMID 9662329 DOI: 10.1038/Sj.Onc.1201841 |
0.356 |
|
| 1998 |
Johnstone RW, Wang J, Tommerup N, Vissing H, Roberts T, Shi Y. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. Journal of Biological Chemistry. 273: 10880-10887. PMID 9556563 DOI: 10.1074/Jbc.273.18.10880 |
0.361 |
|
| 1998 |
Brownell HL, Lydon NB, Schaefer E, Roberts TM, Raptis L. Inhibition of epidermal growth factor-mediated ERK1/2 activation by in situ electroporation of nonpermeant [(alkylamino)methyl]acrylophenone derivatives. Dna and Cell Biology. 17: 265-74. PMID 9539106 DOI: 10.1089/Dna.1998.17.265 |
0.308 |
|
| 1998 |
Bullock TL, McCoy AJ, Kent HM, Roberts TM, Stewart M. Structural basis for amoeboid motility in nematode sperm. Nature Structural Biology. 5: 184-9. PMID 9501910 DOI: 10.1038/Nsb0398-184 |
0.38 |
|
| 1998 |
Batt DB, Roberts TM. Cell density modulates protein-tyrosine phosphorylation Journal of Biological Chemistry. 273: 3408-3414. PMID 9452462 DOI: 10.1074/Jbc.273.6.3408 |
0.377 |
|
| 1998 |
Roberts TM, Salmon ED, Stewart M. Hydrostatic pressure shows that lamellipodial motility in Ascaris sperm requires membrane-associated major sperm protein filament nucleation and elongation. The Journal of Cell Biology. 140: 367-75. PMID 9442112 DOI: 10.1083/Jcb.140.2.367 |
0.363 |
|
| 1998 |
Culleré X, Rose P, Thathamangalam U, Chatterjee A, Mullane KP, Pallas DC, Benjamin TL, Roberts TM, Schaffhausen BS. Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins. Journal of Virology. 72: 558-63. PMID 9420259 DOI: 10.1128/Jvi.72.1.558-563.1998 |
0.393 |
|
| 1997 |
Roberts TM, Stewart M. Nematode sperm: amoeboid movement without actin. Trends in Cell Biology. 7: 368-73. PMID 17708982 DOI: 10.1016/S0962-8924(97)01113-6 |
0.395 |
|
| 1997 |
Sheng Q, Denis D, Ratnofsky M, Roberts TM, Decaprio JA, Schaffhausen B. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function Journal of Virology. 71: 9410-9416. PMID 9371601 DOI: 10.1128/Jvi.71.12.9410-9416.1997 |
0.303 |
|
| 1997 |
Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase Science. 276: 1848-1850. PMID 9188528 DOI: 10.1126/Science.276.5320.1848 |
0.318 |
|
| 1997 |
Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, D'Andrea AD, Dearolf CR. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Molecular and Cellular Biology. 17: 1562-71. PMID 9032284 DOI: 10.1128/Mcb.17.3.1562 |
0.342 |
|
| 1996 |
Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, Haber DA, Licht JD, Sugrue SP, Roberts T, Rangnekar VM, Shi Y. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Molecular and Cellular Biology. 16: 6945-56. PMID 8943350 DOI: 10.1128/Mcb.16.12.6945 |
0.315 |
|
| 1996 |
Bullock TL, Roberts TM, Stewart M. 2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum. Journal of Molecular Biology. 263: 284-96. PMID 8913307 DOI: 10.1006/Jmbi.1996.0575 |
0.358 |
|
| 1996 |
Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM. The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 93: 11681-6. PMID 8876196 DOI: 10.1073/Pnas.93.21.11681 |
0.365 |
|
| 1996 |
Bullock TL, Parthasarathy G, King KL, Kent HM, Roberts TM, Stewart M. New crystal forms of the motile major sperm protein (MSP) of Ascaris suum. Journal of Structural Biology. 116: 432-7. PMID 8813002 DOI: 10.1006/Jsbi.1996.0061 |
0.637 |
|
| 1996 |
Nam HJ, Haser WG, Roberts TM, Frederick CA. Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism. Structure (London, England : 1993). 4: 1105-14. PMID 8805596 DOI: 10.1016/S0969-2126(96)00116-5 |
0.306 |
|
| 1996 |
Auger KR, Songyang Z, Lo SH, Roberts TM, Chen LB. Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes. The Journal of Biological Chemistry. 271: 23452-7. PMID 8798552 DOI: 10.1074/Jbc.271.38.23452 |
0.369 |
|
| 1996 |
Haaf A, Butler PJ, Kent HM, Fearnley IM, Roberts TM, Neuhaus D, Stewart M. The motile major sperm protein (MSP) from Ascaris suum is a symmetric dimer in solution. Journal of Molecular Biology. 260: 251-60. PMID 8764404 DOI: 10.1006/Jmbi.1996.0396 |
0.418 |
|
| 1996 |
Corbley MJ, Cherington V, Traxler PM, Lydon NB, Roberts TM. A strategy for screening anti-tumor drugs utilizing oncogenes encoded in retroviral vectors. International Journal of Cancer. 66: 753-9. PMID 8647645 DOI: 10.1002/(Sici)1097-0215(19960611)66:6<753::Aid-Ijc8>3.0.Co;2-Z |
0.326 |
|
| 1996 |
Italiano JE, Roberts TM, Stewart M, Fontana CA. Reconstitution in vitro of the motile apparatus from the amoeboid sperm of Ascaris shows that filament assembly and bundling move membranes. Cell. 84: 105-14. PMID 8548814 DOI: 10.1016/S0092-8674(00)80997-6 |
0.401 |
|
| 1996 |
Jung JU, Lang SM, Jun T, Roberts TM, Veillette A, Desrosiers RC. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. Journal of Virology. 69: 7814-22. PMID 7494293 DOI: 10.1128/Jvi.69.12.7814-7822.1995 |
0.381 |
|
| 1995 |
L'Hernault SW, Roberts TM. Cell biology of nematode sperm Methods in Cell Biology. 48: 273-301. PMID 8531729 DOI: 10.1016/S0091-679X(08)61392-8 |
0.346 |
|
| 1995 |
Wang J, Auger KR, Jarvis L, Shi Y, Roberts TM. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 270: 12774-80. PMID 7759531 DOI: 10.1074/Jbc.270.21.12774 |
0.36 |
|
| 1995 |
Su W, Liu W, Schaffhausen BS, Roberts TM. Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. The Journal of Biological Chemistry. 270: 12331-4. PMID 7759472 DOI: 10.1074/Jbc.270.21.12331 |
0.385 |
|
| 1995 |
Roberts TM, Stewart M. Nematode sperm locomotion Current Opinion in Cell Biology. 7: 13-17. PMID 7755984 DOI: 10.1016/0955-0674(95)80039-5 |
0.397 |
|
| 1995 |
Holliday LS, Roberts TM. Isolation and characterization of 30-nm protein particles present in pseudopods of the amoeboid sperm of Ascaris suum. Biochemical and Biophysical Research Communications. 208: 1073-9. PMID 7702606 DOI: 10.1006/Bbrc.1995.1444 |
0.625 |
|
| 1995 |
Royal D, Royal M, Italiano J, Roberts T, Soll DR. In Ascaris sperm pseudopods, MSP fibers move proximally at a constant rate regardless of the forward rate of cellular translocation. Cell Motility and the Cytoskeleton. 31: 241-53. PMID 7585993 DOI: 10.1002/Cm.970310307 |
0.323 |
|
| 1995 |
Jung JU, Lang SM, Friedrich U, Jun T, Roberts TM, Desrosiers RC, Biesinger B. Identification of Lck-binding elements in tip of herpesvirus saimiri. The Journal of Biological Chemistry. 270: 20660-7. PMID 7544793 DOI: 10.1074/Jbc.270.35.20660 |
0.39 |
|
| 1995 |
Campbell KS, Auger KR, Hemmings BA, Roberts TM, Pallas DC. Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A Journal of Virology. 69: 3721-3728. PMID 7538174 DOI: 10.1128/Jvi.69.6.3721-3728.1995 |
0.362 |
|
| 1995 |
Carrera AC, Paradis H, Borlado LR, Roberts TM, Martinez AC. Lck unique domain influences Lck specificity and biological function Journal of Biological Chemistry. 270: 3385-3391. PMID 7531706 DOI: 10.1074/Jbc.270.7.3385 |
0.315 |
|
| 1995 |
Carrera AC, Borlado LR, Roberts TM, Martinez C. Tyrosine kinase specific motif at subdomain VIII does not confer specificity for tyrosine. Biochemical and Biophysical Research Communications. 205: 1114-20. PMID 7528498 DOI: 10.1006/Bbrc.1994.2781 |
0.328 |
|
| 1994 |
Williams NG, Roberts TM. Signal transduction pathways involving the raf proto-oncogene Cancer and Metastasis Reviews. 13: 105-116. PMID 8143342 DOI: 10.1007/Bf00690421 |
0.374 |
|
| 1994 |
Pallas DC, Fu H, Haehnel LC, Weller W, Collier RJ, Roberts TM. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science (New York, N.Y.). 265: 535-7. PMID 8036498 DOI: 10.1126/Science.8036498 |
0.405 |
|
| 1994 |
Campbell KS, Ogris E, Burke B, Su W, Auger KR, Druker BJ, Schaffhausen BS, Roberts TM, Pallas DC. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen Proceedings of the National Academy of Sciences of the United States of America. 91: 6344-6348. PMID 8022784 DOI: 10.1073/Pnas.91.14.6344 |
0.421 |
|
| 1994 |
King KL, Essig J, Roberts TM, Moerland TS. Regulation of the Ascaris major sperm protein (MSP) cytoskeleton by intracellular pH. Cell Motility and the Cytoskeleton. 27: 193-205. PMID 8020106 DOI: 10.1002/Cm.970270302 |
0.69 |
|
| 1994 |
Fu H, Xia K, Pallas DC, Cui C, Conroy K, Narsimhan RP, Mamon H, Collier RJ, Roberts TM. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science (New York, N.Y.). 266: 126-9. PMID 7939632 DOI: 10.1126/Science.7939632 |
0.382 |
|
| 1994 |
Stewart M, King KL, Roberts TM. The motile major sperm protein (MSP) of Ascaris suum forms filaments constructed from two helical subfilaments. Journal of Molecular Biology. 243: 60-71. PMID 7932742 DOI: 10.1006/Jmbi.1994.1630 |
0.702 |
|
| 1994 |
King KL, Stewart M, Roberts TM. Supramolecular assemblies of the Ascaris suum major sperm protein (MSP) associated with amoeboid cell motility. Journal of Cell Science. 107: 2941-9. PMID 7876359 |
0.676 |
|
| 1993 |
Lu X, Chou TB, Williams NG, Roberts T, Perrimon N. Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes & Development. 7: 621-32. PMID 8458578 DOI: 10.1101/Gad.7.4.621 |
0.364 |
|
| 1993 |
Carrera AC, Alexandrov K, Roberts TM. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP Proceedings of the National Academy of Sciences of the United States of America. 90: 442-446. PMID 8421674 DOI: 10.1073/Pnas.90.2.442 |
0.35 |
|
| 1993 |
Williams NG, Paradis H, Agarwal S, Charest DL, Pelech SL, Roberts TM. Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase Proceedings of the National Academy of Sciences of the United States of America. 90: 5772-5776. PMID 8390681 DOI: 10.1073/Pnas.90.12.5772 |
0.309 |
|
| 1993 |
Wood KW, Qi H, D'Arcangelo G, Armstrong RC, Roberts TM, Halegoua S. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 90: 5016-20. PMID 8389463 DOI: 10.1073/Pnas.90.11.5016 |
0.338 |
|
| 1993 |
Wood KW, Roberts TM. Oncogenes and protein kinases in neuronal growth-factor action Bba - Reviews On Cancer. 1155: 133-150. PMID 8357824 DOI: 10.1016/0304-419X(93)90002-T |
0.308 |
|
| 1993 |
Stewart M, King KL, Roberts TM. Crystallization of the motile major sperm protein (MSP) of the nematode Ascaris suum. Journal of Molecular Biology. 232: 298-300. PMID 8331665 DOI: 10.1006/Jmbi.1993.1383 |
0.653 |
|
| 1992 |
King KL, Stewart M, Roberts TM, Seavy M. Structure and macromolecular assembly of two isoforms of the major sperm protein (MSP) from the amoeboid sperm of the nematode, Ascaris suum. Journal of Cell Science. 101: 847-57. PMID 1527183 |
0.666 |
|
| 1992 |
Williams NG, Roberts TM, Li P. Both p21ras and pp60v-sre are required, but neither alone is sufficient, to activate the Raf-1 kinase Proceedings of the National Academy of Sciences of the United States of America. 89: 2922-2926. PMID 1372995 DOI: 10.1073/Pnas.89.7.2922 |
0.398 |
|
| 1992 |
Ling LE, Druker BJ, Cantley LC, Roberts TM. Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. Journal of Virology. 66: 1702-8. PMID 1371171 DOI: 10.1128/Jvi.66.3.1702-1708.1992 |
0.37 |
|
| 1992 |
Pallas DC, Weller W, Jaspers S, Miller TB, Lane WS, Roberts TM. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens Journal of Virology. 66: 886-893. PMID 1370560 DOI: 10.1128/Jvi.66.2.886-893.1992 |
0.336 |
|
| 1992 |
Epstein RJ, Druker BJ, Roberts TM, Stiles CD. Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 10435-9. PMID 1359539 DOI: 10.1073/Pnas.89.21.10435 |
0.397 |
|
| 1992 |
Dent P, Haser W, Haystead TAJ, Vincent LA, Roberts TM, Sturgill TW. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro Science. 257: 1404-1407. PMID 1326789 DOI: 10.1126/Science.1326789 |
0.371 |
|
| 1992 |
Wood KW, Sarnecki C, Roberts TM, Blenis J. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell. 68: 1041-50. PMID 1312393 DOI: 10.1016/0092-8674(92)90076-O |
0.329 |
|
| 1992 |
Lydon NB, Gay B, Mett H, Murray B, Liebetanz J, Gutzwiller A, Piwnica-Worms H, Roberts TM, McGlynn E. Purification and biochemical characterization of non-myristoylated recombinant pp60(c-src) kinase Biochemical Journal. 287: 985-993. PMID 1280108 DOI: 10.1042/Bj2870985 |
0.305 |
|
| 1992 |
Druker B, Okuda K, Matulonis U, Salgia R, Roberts T, Griffin J. Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines Blood. 79: 2215-2220. DOI: 10.1182/Blood.V79.9.2215.2215 |
0.406 |
|
| 1991 |
Ramer SE, Winkler DG, Carrera A, Roberts TM, Walsh CT. Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. Proceedings of the National Academy of Sciences of the United States of America. 88: 6254-8. PMID 2068105 DOI: 10.1073/Pnas.88.14.6254 |
0.358 |
|
| 1991 |
Carrera AC, Li P, Roberts TM. Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck International Immunology. 3: 673-682. PMID 1911540 DOI: 10.1093/Intimm/3.7.673 |
0.394 |
|
| 1991 |
Li P, Wood K, Mamon H, Haser W, Roberts T. Raf-1: a kinase currently without a cause but not lacking in effects. Cell. 64: 479-482. PMID 1846778 DOI: 10.1016/0092-8674(91)90228-Q |
0.334 |
|
| 1991 |
Roberts TM, King KL. Centripetal flow and directed reassembly of the major sperm protein (MSP) cytoskeleton in the amoeboid sperm of the nematode, Ascaris suum. Cell Motility and the Cytoskeleton. 20: 228-41. PMID 1773449 DOI: 10.1002/Cm.970200306 |
0.678 |
|
| 1991 |
Longnecker R, Druker B, Roberts TM, Kieff E. An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase. Journal of Virology. 65: 3681-92. PMID 1710288 DOI: 10.1128/Jvi.65.7.3681-3692.1991 |
0.376 |
|
| 1991 |
Davis S, Lu ML, Lo SH, Lin S, Butler JA, Druker BJ, Roberts TM, An Q, Chen LB. Presence of an SH2 domain in the actin-binding protein tensin. Science (New York, N.Y.). 252: 712-5. PMID 1708917 DOI: 10.1126/Science.1708917 |
0.399 |
|
| 1991 |
Druker BJ, Roberts TM. Generation of a large library of point mutations in polymamiddle T antigen Nucleic Acids Research. 19: 6855-6861. PMID 1662365 DOI: 10.1093/Nar/19.24.6855 |
0.331 |
|
| 1991 |
Anderson NG, Li P, Marsden LA, Williams N, Roberts TM, Sturgill TW. Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo Biochemical Journal. 277: 573-576. PMID 1650188 DOI: 10.1042/Bj2770573 |
0.342 |
|
| 1991 |
Kanakura Y, Druker B, Wood K, Mamon H, Okuda K, Roberts T, Griffin J. Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line Blood. 77: 243-248. DOI: 10.1182/Blood.V77.2.243.Bloodjournal772243 |
0.337 |
|
| 1990 |
Klaiber K, Williams N, Roberts TM, Papazian DM, Jan LY, Miller C. Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line. Neuron. 5: 221-6. PMID 2200450 DOI: 10.1016/0896-6273(90)90311-3 |
0.31 |
|
| 1990 |
Serunian LA, Auger KR, Roberts TM, Cantley LC. Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen. Journal of Virology. 64: 4718-25. PMID 2168961 DOI: 10.1128/Jvi.64.10.4718-4725.1990 |
0.337 |
|
| 1990 |
Druker BJ, Ling LE, Cohen B, Roberts TM, Schaffhausen BS. A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity. Journal of Virology. 64: 4454-61. PMID 2166824 DOI: 10.1128/Jvi.64.9.4454-4461.1990 |
0.341 |
|
| 1990 |
Cohen B, Liu YX, Druker B, Roberts TM, Schaffhausen BS. Characterization of pp85, a target of oncogenes and growth factor receptors. Molecular and Cellular Biology. 10: 2909-15. PMID 2160590 DOI: 10.1128/Mcb.10.6.2909 |
0.315 |
|
| 1990 |
Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A Cell. 60: 167-176. PMID 2153055 DOI: 10.1016/0092-8674(90)90726-U |
0.342 |
|
| 1990 |
Piwnica-Worms H, Williams NG, Cheng SH, Roberts TM. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells Journal of Virology. 64: 61-68. PMID 2152834 DOI: 10.1128/Jvi.64.1.61-68.1990 |
0.384 |
|
| 1990 |
Cohen B, Yoakim M, Piwnica-Worms H, Roberts TM, Schaffhausen BS. Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity Proceedings of the National Academy of Sciences of the United States of America. 87: 4458-4462. PMID 1693771 DOI: 10.1073/Pnas.87.12.4458 |
0.366 |
|
| 1989 |
Pallas DC, Morgan W, Roberts TM. The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cell include the major human 70-kilodalton heat shock proteins Journal of Virology. 63: 4533-4539. PMID 2795710 DOI: 10.1128/Jvi.63.11.4533-4539.1989 |
0.376 |
|
| 1989 |
Druker BJ, Mamon HJ, Roberts TM. Oncogenes, growth factors, and signal transduction. The New England Journal of Medicine. 321: 1383-91. PMID 2682241 DOI: 10.1056/Nejm198911163212007 |
0.308 |
|
| 1989 |
Pavalko FM, Roberts TM. Posttranslational insertion of a membrane protein on Caenorhabditis elegans sperm occurs without de novo protein synthesis. Journal of Cellular Biochemistry. 41: 57-70. PMID 2613747 DOI: 10.1002/Jcb.240410203 |
0.74 |
|
| 1989 |
Varticovski L, Druker B, Morrison D, Cantley L, Roberts T. The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase Nature. 342: 699-702. PMID 2556641 DOI: 10.1038/342699A0 |
0.328 |
|
| 1989 |
Cheng SH, Harvey R, Piwnica-Worms H, Espino PC, Roberts TM, Smith AE. Mechanism of activation of complexed pp60c-src by the middle T antigen of polyomavirus Current Topics in Microbiology and Immunology. 144: 109-120. PMID 2477197 DOI: 10.1007/978-3-642-74578-2_14 |
0.302 |
|
| 1989 |
Kaplan DR, Pallas DC, Morgan W, Schaffhausen B, Roberts TM. Mechanisms of transformation by polyoma virus middle T antigen Bba - Reviews On Cancer. 948: 345-364. PMID 2465782 DOI: 10.1016/0304-419X(89)90006-1 |
0.375 |
|
| 1988 |
Pavalko FM, Roberts TM, Holliday LS. Relationship between plasma membrane mobility and substrate attachment in the crawling movement of spermatozoa from Caenorhabditis elegans. Cell Motility and the Cytoskeleton. 11: 16-23. PMID 3208296 DOI: 10.1002/Cm.970110103 |
0.804 |
|
| 1988 |
Morrison DK, Kaplan DR, Rapp U, Roberts TM. Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 85: 8855-9. PMID 3057494 DOI: 10.1073/Pnas.85.23.8855 |
0.401 |
|
| 1988 |
Pallas DC, Cherington V, Morgan W, DeAnda J, Kaplan D, Schaffhausen B, Roberts TM. Cellular proteins that associate with the middle and small T antigens of polyomavirus Journal of Virology. 62: 3934-3940. PMID 2845116 DOI: 10.1128/Jvi.62.11.3934-3940.1988 |
0.384 |
|
| 1988 |
Morgan WC, Kaplan DR, Pallas DC, Roberts TM. Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: Separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro Journal of Virology. 62: 3407-3414. PMID 2841493 DOI: 10.1128/Jvi.62.9.3407-3414.1988 |
0.332 |
|
| 1988 |
Cherington V, Brown M, Paucha E, St Louis J, Spiegelman BM, Roberts TM. Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation. Molecular and Cellular Biology. 8: 1380-4. PMID 2835674 DOI: 10.1128/Mcb.8.3.1380 |
0.32 |
|
| 1988 |
Figge J, Wright C, Collins CJ, Roberts TM, Livingston DM. Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell. 52: 713-22. PMID 2830990 DOI: 10.1016/0092-8674(88)90409-6 |
0.332 |
|
| 1988 |
Whitman M, Kaplan D, Roberts T, Cantley L. Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. The Biochemical Journal. 247: 165-74. PMID 2825654 DOI: 10.1042/Bj2470165 |
0.36 |
|
| 1988 |
Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate Nature. 336: 738-744. PMID 2462672 DOI: 10.1038/336738A0 |
0.4 |
|
| 1988 |
Morrison DK, Browning PJ, White MF, Roberts TM. Tyrosine phosphorylations in vivo associated with v-fms transformation Molecular and Cellular Biology. 8: 176-185. PMID 2447483 DOI: 10.1128/Mcb.8.1.176 |
0.35 |
|
| 1987 |
Pavalko FM, Roberts TM. Caenorhabditis elegans spermatozoa assemble membrane proteins onto the surface at the tips of pseudopodial projections. Cell Motility and the Cytoskeleton. 7: 169-77. PMID 3555849 DOI: 10.1002/Cm.970070209 |
0.723 |
|
| 1987 |
Roberts TM. Fine (2-5-nm) filaments: new types of cytoskeletal structures Cell Motility and the Cytoskeleton. 8: 130-142. PMID 3319196 DOI: 10.1002/Cm.970080205 |
0.371 |
|
| 1987 |
Piwnica-Worms H, Saunders KB, Roberts TM, Smith AE, Cheng SH. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src Cell. 49: 75-82. PMID 3103926 DOI: 10.1016/0092-8674(87)90757-4 |
0.359 |
|
| 1987 |
Ballmer-Hofer K, Mandel G, Faller DV, Roberts TM, Benjamin TL. Expression of influenza hemagglutinin-polyoma T-antigen fusion proteins in a rat embryo fibroblast cell line. Virus Research. 6: 345-61. PMID 3031893 DOI: 10.1016/0168-1702(87)90066-9 |
0.39 |
|
| 1987 |
Kishimoto TK, O'Connor K, Lee A, Roberts TM, Springer TA. Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell. 48: 681-90. PMID 3028646 DOI: 10.1016/0092-8674(87)90246-7 |
0.322 |
|
| 1987 |
Feig LA, Corbley M, Pan BT, Roberts TM, Cooper GM. Structure/function analysis of ras using random mutagenesis coupled with functional screening assays Molecular Endocrinology (Baltimore, Md.). 1: 127-136. PMID 2842663 DOI: 10.1210/Mend-1-2-127 |
0.321 |
|
| 1987 |
Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity Cell. 50: 1021-1029. PMID 2441878 DOI: 10.1016/0092-8674(87)90168-1 |
0.375 |
|
| 1987 |
Cantley LC, Whitman M, Chahwala S, Fleischman L, Kaplan DR, Schaffhausen BS, Roberts TM. Oncogenes and phosphatidylinositol turnover. Annals of the New York Academy of Sciences. 488: 481-90. PMID 2437850 DOI: 10.1111/j.1749-6632.1986.tb46580.x |
0.32 |
|
| 1987 |
Schaffhausen BS, Bockus BJ, Berkner KL, Kaplan D, Roberts TM. Characterization of middle T antigen expressed by using an adenovirus expression system. Journal of Virology. 61: 1221-5. PMID 2434665 DOI: 10.1128/Jvi.61.4.1221-1225.1987 |
0.33 |
|
| 1986 |
Roberts TM, Pavalko FM, Ward S. Membrane and cytoplasmic proteins are transported in the same organelle complex during nematode spermatogenesis Journal of Cell Biology. 102: 1787-1796. PMID 3517007 DOI: 10.1083/Jcb.102.5.1787 |
0.764 |
|
| 1986 |
Piwnica-Worms H, Kaplan DR, Whitman M, Roberts TM. Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo Molecular and Cellular Biology. 6: 2033-2040. PMID 2431288 DOI: 10.1128/Mcb.6.6.2033 |
0.376 |
|
| 1986 |
Gee CE, Griffin J, Sastre L, Miller LJ, Springer TA, Piwnica-Worms H, Roberts TM. Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 5131-5. PMID 2425362 DOI: 10.1073/Pnas.83.14.5131 |
0.367 |
|
| 1986 |
Kaplan DR, Whitman M, Schaffhausen B, Raptis L, Garcea RL, Pallas D, Roberts TM, Cantley L. Phosphatidylinositol metabolism and polyoma-mediated transformation. Proceedings of the National Academy of Sciences of the United States of America. 83: 3624-8. PMID 2424008 DOI: 10.1073/Pnas.83.11.3624 |
0.349 |
|
| 1986 |
Ward S, Roberts TM, Strome S, Pavalko FM, Hogan E. Monoclonal antibodies that recognize a polypeptide antigenic determinant shared by multiple Caenorhabditis elegans sperm-specific proteins Journal of Cell Biology. 102: 1778-1786. PMID 2422180 DOI: 10.1083/Jcb.102.5.1778 |
0.727 |
|
| 1985 |
Kaplan DR, Bockus B, Roberts TM, Bolen J, Israel M, Schaffhausen BS. Large-scale production of polyoma middle T antigen by using genetically engineered tumors. Molecular and Cellular Biology. 5: 1795-9. PMID 2991752 DOI: 10.1128/Mcb.5.7.1795 |
0.307 |
|
| 1985 |
Schaffhausen B, Benjamin TL, Lodge J, Kaplan D, Roberts TM. Expression of polyoma early gene products in E. coli. Nucleic Acids Research. 13: 501-19. PMID 2987799 DOI: 10.1093/Nar/13.2.501 |
0.342 |
|
| 1985 |
Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature. 315: 239-42. PMID 2987699 DOI: 10.1038/315239A0 |
0.336 |
|
| 1984 |
Ellman M, Bikel I, Figge J, Roberts T, Schlossman R, Livingston DM. Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells Journal of Virology. 50: 623-628. PMID 6323762 DOI: 10.1128/Jvi.50.2.623-628.1984 |
0.314 |
|
| 1983 |
Bikel I, Roberts TM, Bladon MT, Green R, Amann E, Livingston DM. Purification of biologically active simian virus 40 small tumor antigen Proceedings of the National Academy of Sciences of the United States of America. 80: 906-910. PMID 6302673 DOI: 10.1073/Pnas.80.4.906 |
0.345 |
|
| 1983 |
Roberts TM. Crawling caenorhabditis elegans spermatozoa contact the substrate only by their pseudopods and contain 2‐nm filaments Cytoskeleton. 3: 333-347. DOI: 10.1002/Cm.970030405 |
0.407 |
|
| 1982 |
Ward S, Roberts TM, Nelson GA, Argon Y. The Development and Motility of Caenorhabditis elegans Spermatozoa. Journal of Nematology. 14: 259-66. PMID 19295707 |
0.644 |
|
| 1982 |
Nelson GA, Roberts TM, Ward S. Caenorhabditis elegans spermatozoan locomotion: Amoeboid movement with almost no actin Journal of Cell Biology. 92: 121-131. PMID 7199049 DOI: 10.1083/Jcb.92.1.121 |
0.491 |
|
| 1982 |
Roberts TM, Ward S. Centripetal flow of pseudopodial surface components could propel the amoeboid movement of Caenorhabditis elegans spermatozoa Journal of Cell Biology. 92: 132-138. PMID 7056796 |
0.457 |
|
| 1982 |
Roberts TM, Ward S. Membrane flow during nematode spermiogenesis Journal of Cell Biology. 92: 113-120. PMID 7056795 |
0.426 |
|
| 1982 |
Roberts TM, Ward S. Directed membrane flow on the pseudopods of Caenorhabditis elegans spermatozoa Cold Spring Harbor Symposia On Quantitative Biology. 46: 697-702. PMID 6955104 |
0.403 |
|
| 1979 |
Roberts TM, Ward S, Chernin E. Behavioral responses of Schistosoma mansoni miracidia in concentration gradients of snail-conditioned water Journal of Parasitology. 65: 41-49. PMID 448598 DOI: 10.2307/3280200 |
0.435 |
|
| 1978 |
Roberts TM, Stibbs HH, Chernin E, Ward S. A simple quantitative technique for testing behavioral responses of Schistosoma mansoni miracidia to chemicals Journal of Parasitology. 64: 277-282. PMID 25318 DOI: 10.2307/3279673 |
0.435 |
|
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