Philip A. Marsden - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology, Cell Biology, Oncology

158 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Turgeon PJ, Chan GC, Chen L, Jamal AN, Yan MS, Ho JJD, Yuan L, Ibeh N, Ku KH, Cybulsky MI, Aird WC, Marsden PA. Epigenetic Heterogeneity and Mitotic Heritability Prime Endothelial Cell Gene Induction. Journal of Immunology (Baltimore, Md. : 1950). PMID 31996458 DOI: 10.4049/jimmunol.1900744  1
2018 Man HSJ, Sukumar AN, Ku KH, Dubinsky MK, Subramaniam N, Marsden PA. Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers. Journal of Visualized Experiments : Jove. PMID 30394398 DOI: 10.3791/58478  0.32
2018 Man HSJ, Sukumar AN, Lam GC, Turgeon PJ, Yan MS, Ku KH, Dubinsky MK, Ho JJD, Wang JJ, Das S, Mitchell N, Oettgen P, Sefton MV, Marsden PA. Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 29467285 DOI: 10.1073/pnas.1715182115  1
2018 Yan MS, Turgeon PJ, Man HSJ, Dubinsky MK, Ho JJD, El-Rass S, Wang YD, Wen XY, Marsden PA. Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. The Journal of Biological Chemistry. PMID 29414790 DOI: 10.1074/jbc.RA117.001383  1
2016 Man HJ, Yan MS, Lee JJ, Marsden PA. Epigenetic determinants of cardiovascular gene expression: vascular endothelium. Epigenomics. PMID 27381277 DOI: 10.2217/epi-2016-0012  1
2016 Yuan L, Chan GC, Beeler D, Janes L, Spokes KC, Dharaneeswaran H, Mojiri A, Adams WJ, Sciuto T, Garcia-Cardeña G, Molema G, Kang PM, Jahroudi N, Marsden PA, Dvorak A, et al. A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. Nature Communications. 7: 10160. PMID 26744078 DOI: 10.1038/ncomms10160  0.36
2015 Yan MS, Marsden PA. Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 2297-306. PMID 26404488 DOI: 10.1161/ATVBAHA.115.305043  0.4
2015 Ho JJ, Marsden PA. Posttranscriptional adaptations of the vascular endothelium to hypoxia. Current Opinion in Hematology. 22: 243-51. PMID 25767954 DOI: 10.1097/MOH.0000000000000139  1
2014 Turgeon PJ, Sukumar AN, Marsden PA. Epigenetics of Cardiovascular Disease - A New "Beat" in Coronary Artery Disease. Medical Epigenetics. 2: 37-52. PMID 25408699 DOI: 10.1159/000360766  0.32
2014 Jeffrey Man HS, Tsui AK, Marsden PA. Nitric oxide and hypoxia signaling. Vitamins and Hormones. 96: 161-92. PMID 25189387 DOI: 10.1016/B978-0-12-800254-4.00007-6  1
2014 Cybulsky MI, Marsden PA. Effect of disturbed blood flow on endothelial cell gene expression: a role for changes in RNA processing. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1806-8. PMID 25142881 DOI: 10.1161/ATVBAHA.114.304099  1
2014 Tsui AK, Marsden PA, Mazer CD, Sled JG, Lee KM, Henkelman RM, Cahill LS, Zhou YQ, Chan N, Liu E, Hare GM. Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R13-25. PMID 24760996 DOI: 10.1152/ajpregu.00411.2013  1
2014 Chen LH, Advani SL, Thai K, Kabir MG, Sood MM, Gibson IW, Yuen DA, Connelly KA, Marsden PA, Kelly DJ, Gilbert RE, Advani A. SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease. Plos One. 9: e92227. PMID 24637920 DOI: 10.1371/journal.pone.0092227  1
2014 Ho JJ, Marsden PA. Competition and collaboration between RNA-binding proteins and microRNAs. Wiley Interdisciplinary Reviews. Rna. 5: 69-86. PMID 24124109 DOI: 10.1002/wrna.1197  1
2013 Das S, Marsden PA. Angiogenesis in glioblastoma. The New England Journal of Medicine. 369: 1561-3. PMID 24131182 DOI: 10.1056/NEJMcibr1309402  1
2013 Ingelfinger JR, Marsden PA. Estimated GFR and risk of death--is cystatin C useful? The New England Journal of Medicine. 369: 974-5. PMID 24004125 DOI: 10.1056/NEJMe1308505  1
2013 Petruzziello-Pellegrini TN, Moslemi-Naeini M, Marsden PA. New insights into Shiga toxin-mediated endothelial dysfunction in hemolytic uremic syndrome. Virulence. 4: 556-63. PMID 23955166 DOI: 10.4161/viru.26143  1
2013 Yuen DA, Connelly KA, Zhang Y, Advani SL, Thai K, Kabir G, Kepecs D, Spring C, Smith C, Batruch I, Kosanam H, Advani A, Diamandis E, Marsden PA, Gilbert RE. Early outgrowth cells release soluble endocrine antifibrotic factors that reduce progressive organ fibrosis. Stem Cells (Dayton, Ohio). 31: 2408-19. PMID 23922321 DOI: 10.1002/stem.1502  1
2013 Page AV, Tarr PI, Watkins SL, Rajwans N, Petruzziello-Pellegrini TN, Marsden PA, Kain KC, Liles WC. Dysregulation of angiopoietin 1 and 2 in Escherichia coli O157:H7 infection and the hemolytic-uremic syndrome. The Journal of Infectious Diseases. 208: 929-33. PMID 23801605 DOI: 10.1093/infdis/jit268  1
2013 Ho JJ, Robb GB, Tai SC, Turgeon PJ, Mawji IA, Man HS, Marsden PA. Active stabilization of human endothelial nitric oxide synthase mRNA by hnRNP E1 protects against antisense RNA and microRNAs. Molecular and Cellular Biology. 33: 2029-46. PMID 23478261 DOI: 10.1128/MCB.01257-12  1
2013 Shirodkar AV, St Bernard R, Gavryushova A, Kop A, Knight BJ, Yan MS, Man HS, Sud M, Hebbel RP, Oettgen P, Aird WC, Marsden PA. A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood. 121: 3531-40. PMID 23449636 DOI: 10.1182/blood-2013-01-479170  1
2013 Webster AL, Yan MS, Marsden PA. Epigenetics and cardiovascular disease. The Canadian Journal of Cardiology. 29: 46-57. PMID 23261320 DOI: 10.1016/j.cjca.2012.10.023  1
2012 Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta N, Steer BM, Ingram AJ, Gupta M, Al-Omran M, Teoh H, Marsden PA, Verma S. MicroRNA-145 targeted therapy reduces atherosclerosis. Circulation. 126: S81-90. PMID 22965997 DOI: 10.1161/CIRCULATIONAHA.111.084186  1
2012 Ho JJ, Metcalf JL, Yan MS, Turgeon PJ, Wang JJ, Chalsev M, Petruzziello-Pellegrini TN, Tsui AK, He JZ, Dhamko H, Man HS, Robb GB, Teh BT, Ohh M, Marsden PA. Functional importance of Dicer protein in the adaptive cellular response to hypoxia. The Journal of Biological Chemistry. 287: 29003-20. PMID 22745131 DOI: 10.1074/jbc.M112.373365  1
2012 Petruzziello-Pellegrini TN, Marsden PA. Shiga toxin-associated hemolytic uremic syndrome: advances in pathogenesis and therapeutics. Current Opinion in Nephrology and Hypertension. 21: 433-40. PMID 22660553 DOI: 10.1097/MNH.0b013e328354a62e  1
2012 Yuen DA, Gilbert RE, Marsden PA. Bone marrow cell therapies for endothelial repair and their relevance to kidney disease. Seminars in Nephrology. 32: 215-23. PMID 22617771 DOI: 10.1016/j.semnephrol.2012.02.008  1
2012 Jamal A, Man HS, Marsden PA. Gene regulation in the vascular endothelium: why epigenetics is important for the kidney. Seminars in Nephrology. 32: 176-84. PMID 22617766 DOI: 10.1016/j.semnephrol.2012.02.009  1
2012 Marsden PA. The vascular endothelium: a wonderful network: introduction. Seminars in Nephrology. 32: 143-4. PMID 22617762 DOI: 10.1016/j.semnephrol.2012.03.001  1
2012 Ho JJ, Man HS, Marsden PA. Nitric oxide signaling in hypoxia. Journal of Molecular Medicine (Berlin, Germany). 90: 217-31. PMID 22349396 DOI: 10.1007/s00109-012-0880-5  1
2012 Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, ... ... Marsden PA, et al. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice. The Journal of Clinical Investigation. 122: 759-76. PMID 22232208 DOI: 10.1172/JCI57313  1
2011 Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proceedings of the National Academy of Sciences of the United States of America. 108: 17544-9. PMID 21976486 DOI: 10.1073/pnas.1114026108  1
2011 Man HSJ, Marsden PA. Pulse oximetry [8] New England Journal of Medicine. 365: 184-185. PMID 21751929 DOI: 10.1056/NEJMc1105847  1
2011 Advani A, Huang Q, Thai K, Advani SL, White KE, Kelly DJ, Yuen DA, Connelly KA, Marsden PA, Gilbert RE. Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. The American Journal of Pathology. 178: 2205-14. PMID 21514434 DOI: 10.1016/j.ajpath.2011.01.044  1
2011 Melnyk MC, Shalev I, Zhang J, Bartczak A, Gorczynski RM, Selzner N, Inman R, Marsden PA, Phillips MJ, Clark DA, Levy GA. The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis. Scandinavian Journal of Rheumatology. 40: 269-78. PMID 21469939 DOI: 10.3109/03009742.2010.536163  1
2011 Shirodkar AV, Marsden PA. Epigenetics in cardiovascular disease. Current Opinion in Cardiology. 26: 209-15. PMID 21415727 DOI: 10.1097/HCO.0b013e328345986e  1
2011 Sabri M, Ai J, Marsden PA, Macdonald RL. Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage. Plos One. 6: e17062. PMID 21373645 DOI: 10.1371/journal.pone.0017062  1
2011 Sabri M, Ai J, Knight B, Tariq A, Jeon H, Shang X, Marsden PA, Loch Macdonald R. Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 190-9. PMID 20517322 DOI: 10.1038/jcbfm.2010.76  1
2010 Tsui AK, Dattani ND, Marsden PA, El-Beheiry MH, Grocott HP, Liu E, Biro GP, Mazer CD, Hare GM. Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 57: 779-91. PMID 20512540 DOI: 10.1007/s12630-010-9329-x  1
2010 Yan MS, Matouk CC, Marsden PA. Epigenetics of the vascular endothelium. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 916-26. PMID 20413423 DOI: 10.1152/japplphysiol.00131.2010  1
2010 Yuen DA, Connelly KA, Advani A, Liao C, Kuliszewski MA, Trogadis J, Thai K, Advani SL, Zhang Y, Kelly DJ, Leong-Poi H, Keating A, Marsden PA, Stewart DJ, Gilbert RE. Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism. Plos One. 5: e9543. PMID 20209052 DOI: 10.1371/journal.pone.0009543  1
2010 He JZ, Ho JJ, Gingerich S, Courtman DW, Marsden PA, Ward ME. Enhanced translation of heme oxygenase-2 preserves human endothelial cell viability during hypoxia. The Journal of Biological Chemistry. 285: 9452-61. PMID 20118244 DOI: 10.1074/jbc.M109.077230  1
2010 Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. The Journal of Biological Chemistry. 285: 810-26. PMID 19880524 DOI: 10.1074/jbc.M109.067868  0.4
2010 Fish JE, Yan MS, Matouk CC, St. Bernard R, Ho JJD, Gavryushova A, Srivastava D, Marsden PA. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones (Journal of Biological Chemistry(2010), 285 (810-826)) Journal of Biological Chemistry. 285: 11754. DOI: 10.1074/jbc.A109.067868  1
2009 Marsden PA. Treatment of anemia in chronic kidney disease--strategies based on evidence. The New England Journal of Medicine. 361: 2089-90. PMID 19880845 DOI: 10.1056/NEJMe0909664  1
2009 Chen Z, Marsden PA, Gorczynski RM. Role of a distal enhancer in the transcriptional responsiveness of the human CD200 gene to interferon-gamma and tumor necrosis factor-alpha. Molecular Immunology. 46: 1951-63. PMID 19386363 DOI: 10.1016/j.molimm.2009.03.015  1
2009 North ML, Khanna N, Marsden PA, Grasemann H, Scott JA. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. 296: L911-20. PMID 19286931 DOI: 10.1152/ajplung.00025.2009  1
2009 Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, ... Marsden PA, et al. Regulation of endocytosis via the oxygen-sensing pathway. Nature Medicine. 15: 319-24. PMID 19252501 DOI: 10.1038/nm.1922  1
2009 Petruzziello TN, Mawji IA, Khan M, Marsden PA. Verotoxin biology: molecular events in vascular endothelial injury. Kidney International. Supplement. S17-9. PMID 19180125 DOI: 10.1038/ki.2008.612  1
2008 Ho JJ, Marsden PA. Dicer cuts the kidney. Journal of the American Society of Nephrology : Jasn. 19: 2043-6. PMID 18923053 DOI: 10.1681/ASN.2008090986  1
2008 Teichert AM, Scott JA, Robb GB, Zhou YQ, Zhu SN, Lem M, Keightley A, Steer BM, Schuh AC, Adamson SL, Cybulsky MI, Marsden PA. Endothelial nitric oxide synthase gene expression during murine embryogenesis: commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system. Circulation Research. 103: 24-33. PMID 18556578 DOI: 10.1161/CIRCRESAHA.107.168567  1
2008 Matouk CC, Marsden PA. Epigenetic regulation of vascular endothelial gene expression. Circulation Research. 102: 873-87. PMID 18436802 DOI: 10.1161/CIRCRESAHA.107.171025  1
2008 Gilbert RE, Marsden PA. Activated protein C and diabetic nephropathy. The New England Journal of Medicine. 358: 1628-30. PMID 18403772 DOI: 10.1056/NEJMcibr0801042  1
2008 Farhat N, Matouk CC, Mamarbachi AM, Marsden PA, Allen BG, Thorin E. Activation of ET B receptors regulates the abundance of ET-1 mRNA in vascular endothelial cells British Journal of Pharmacology. 153: 1420-1431. PMID 18278064 DOI: 10.1038/bjp.2008.25  1
2008 Matouk CC, Marsden PA. Molecular insights into the thrombotic microangiopathies Molecular and Genetic Basis of Renal Disease. 453-480. DOI: 10.1016/B978-1-4160-0252-9.50030-6  1
2007 Won D, Zhu SN, Chen M, Teichert AM, Fish JE, Matouk CC, Bonert M, Ojha M, Marsden PA, Cybulsky MI. Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow. The American Journal of Pathology. 171: 1691-704. PMID 17982133 DOI: 10.2353/ajpath.2007.060860  1
2007 Marsden PA. Low-molecular-weight S-nitrosothiols and blood vessel injury. The Journal of Clinical Investigation. 117: 2377-80. PMID 17786231 DOI: 10.1172/JCI33136  1
2007 Advani A, Kelly DJ, Advani SL, Cox AJ, Thai K, Zhang Y, White KE, Gow RM, Marshall SM, Steer BM, Marsden PA, Rakoczy PE, Gilbert RE. Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions. Proceedings of the National Academy of Sciences of the United States of America. 104: 14448-53. PMID 17726104 DOI: 10.1073/pnas.0703577104  1
2007 Fish JE, Matouk CC, Yeboah E, Bevan SC, Khan M, Patil K, Ohh M, Marsden PA. Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 282: 15652-66. PMID 17403686 DOI: 10.1074/jbc.M608318200  1
2007 Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, Sufan RI, Roberts AM, Wilson LA, Betten M, Vandewalle C, ... ... Marsden PA, et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Molecular and Cellular Biology. 27: 157-69. PMID 17060462 DOI: 10.1128/MCB.00892-06  1
2007 He JZ, Quan A, Xu Y, Teoh H, Wang G, Fish JE, Steer BM, Itohara S, Marsden PA, Davidge ST, Ward ME. Induction of matrix metalloproteinase-2 enhances systemic arterial contraction after hypoxia. American Journal of Physiology. Heart and Circulatory Physiology. 292: H684-93. PMID 16980344 DOI: 10.1152/ajpheart.00538.2006  1
2007 McLaren AT, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui AK, Li X, Yucel Y, Robb M, Boyd SR, Liu E, Yu J, Hare GM. Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R403-14. PMID 16973934 DOI: 10.1152/ajpregu.00403.2006  1
2006 Marsden PA. Inflammation and coagulation in the cardiovascular system: the contribution of influenza. Circulation Research. 99: 1152-3. PMID 17122443 DOI: 10.1161/01.RES.0000251962.44753.7f  1
2006 Marsden PA. RNA interference as potential therapy--not so fast. The New England Journal of Medicine. 355: 953-4. PMID 16943409 DOI: 10.1056/NEJMcibr063864  1
2006 Ding M, Cui S, Li C, Jothy S, Haase V, Steer BM, Marsden PA, Pippin J, Shankland S, Rastaldi MP, Cohen CD, Kretzler M, Quaggin SE. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nature Medicine. 12: 1081-7. PMID 16906157 DOI: 10.1038/nm1460  1
2006 Mawji IA, Marsden PA. RNA transfection is a versatile tool to investigate endothelin-1 posttranscriptional regulation. Experimental Biology and Medicine (Maywood, N.J.). 231: 704-8. PMID 16740984  1
2006 Degousee N, Angoulvant D, Fazel S, Stefanski E, Saha S, Iliescu K, Lindsay TF, Fish JE, Marsden PA, Li RK, Audoly LP, Jakobsson PJ, Rubin BB. c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes. The Journal of Biological Chemistry. 281: 16443-52. PMID 16627484 DOI: 10.1074/jbc.M602815200  1
2006 Fish JE, Marsden PA. Endothelial nitric oxide synthase: Insight into cell-specific gene regulation in the vascular endothelium Cellular and Molecular Life Sciences. 63: 144-162. PMID 16416260 DOI: 10.1007/s00018-005-5421-8  1
2006 Chen Z, Marsden PA, Gorczynski RM. Cloning and characterization of the human CD200 promoter region. Molecular Immunology. 43: 579-87. PMID 15955564 DOI: 10.1016/j.molimm.2005.04.014  1
2005 Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, ... Marsden PA, et al. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. The Journal of Experimental Medicine. 202: 1587-97. PMID 16330817 DOI: 10.1084/jem.20051108  1
2005 Ward ME, Toporsian M, Scott JA, Teoh H, Govindaraju V, Quan A, Wener AD, Wang G, Bevan SC, Newton DC, Marsden PA. Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. The Journal of Clinical Investigation. 115: 3128-39. PMID 16276418 DOI: 10.1172/JCI20806  1
2005 Chan GC, Fish JE, Mawji IA, Leung DD, Rachlis AC, Marsden PA. Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 3846-61. PMID 16148131  1
2005 Verma S, Marsden PA. Nitric oxide-eluting polyurethanes--vascular grafts of the future? The New England Journal of Medicine. 353: 730-1. PMID 16107627 DOI: 10.1056/NEJMcibr052030  1
2005 Singh S, Bevan SC, Patil K, Newton DC, Marsden PA. Extensive variation in the 5'-UTR of Dicer mRNAs influences translational efficiency. Biochemical and Biophysical Research Communications. 335: 643-50. PMID 16095561 DOI: 10.1016/j.bbrc.2005.07.138  1
2005 Fish JE, Matouk CC, Rachlis A, Lin S, Tai SC, D'Abreo C, Marsden PA. The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. The Journal of Biological Chemistry. 280: 24824-38. PMID 15870070 DOI: 10.1074/jbc.M502115200  1
2005 Szászi K, Jones JJ, Nathens AB, Lo AY, Marsden PA, Kapus A, Rotstein OD. Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis. Free Radical Biology & Medicine. 38: 1333-43. PMID 15855051 DOI: 10.1016/j.freeradbiomed.2005.01.013  1
2004 Robb GB, Carson AR, Tai SC, Fish JE, Singh S, Yamada T, Scherer SW, Nakabayashi K, Marsden PA. Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript. The Journal of Biological Chemistry. 279: 37982-96. PMID 15234981 DOI: 10.1074/jbc.M400271200  1
2004 Gorczynski R, Chen Z, Kai Y, Lee L, Wong S, Marsden PA. CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. Journal of Immunology (Baltimore, Md. : 1950). 172: 7744-9. PMID 15187158  1
2004 Chan Y, Fish JE, D'Abreo C, Lin S, Robb GB, Teichert AM, Karantzoulis-Fegaras F, Keightley A, Steer BM, Marsden PA. The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation. The Journal of Biological Chemistry. 279: 35087-100. PMID 15180995 DOI: 10.1074/jbc.M405063200  1
2004 Clark DA, Foerster K, Fung L, He W, Lee L, Mendicino M, Markert UR, Gorczynski RM, Marsden PA, Levy GA. The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction. Molecular Human Reproduction. 10: 99-108. PMID 14742694 DOI: 10.1093/molehr/gah013  1
2004 Mawji IA, Robb GB, Tai SC, Marsden PA. Role of the 3'-untranslated region of human endothelin-1 in vascular endothelial cells. Contribution to transcript lability and the cellular heat shock response. The Journal of Biological Chemistry. 279: 8655-67. PMID 14660616 DOI: 10.1074/jbc.M312190200  1
2004 Tai SC, Robb GB, Marsden PA. Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 405-12. PMID 14656742 DOI: 10.1161/01.ATV.0000109171.50229.33  1
2003 Phillips MJ, Azuma T, Meredith SL, Squire JA, Ackerley CA, Pluthero FG, Roberts EA, Superina RA, Levy GA, Marsden PA. Abnormalities in villin gene expression and canalicular microvillus structure in progressive cholestatic liver disease of childhood. Lancet (London, England). 362: 1112-9. PMID 14550699 DOI: 10.1016/S0140-6736(03)14467-4  1
2003 Marsden PA. Predicting outcomes after renal transplantation--new tools and old tools. The New England Journal of Medicine. 349: 182-4. PMID 12853592 DOI: 10.1056/NEJMe030096  1
2003 Marsden PA, Ning Q, Fung LS, Luo X, Chen Y, Mendicino M, Ghanekar A, Scott JA, Miller T, Chan CW, Chan MW, He W, Gorczynski RM, Grant DR, Clark DA, et al. The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. The Journal of Clinical Investigation. 112: 58-66. PMID 12840059 DOI: 10.1172/JCI18114  1
2003 Liu M, Leibowitz JL, Clark DA, Mendicino M, Ning Q, Ding JW, D'Abreo C, Fung L, Marsden PA, Levy GA. Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3. European Journal of Biochemistry / Febs. 270: 2274-86. PMID 12752447 DOI: 10.1046/j.1432-1033.2003.03595.x  1
2003 Degousee N, Martindale J, Stefanski E, Cieslak M, Lindsay TF, Fish JE, Marsden PA, Thuerauf DJ, Glembotski CC, Rubin BB. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Circulation Research. 92: 757-64. PMID 12649265 DOI: 10.1161/01.RES.0000067929.01404.03  1
2003 Marsden PA. Increased body lead burden--cause or consequence of chronic renal insufficiency? The New England Journal of Medicine. 348: 345-7. PMID 12540649 DOI: 10.1056/NEJMe020164  1
2003 Mawji IA, Marsden PA. Perturbations in paracrine control of the circulation: role of the endothelial-derived vasomediators, endothelin-1 and nitric oxide. Microscopy Research and Technique. 60: 46-58. PMID 12500260 DOI: 10.1002/jemt.10242  1
2003 Newton DC, Bevan SC, Choi S, Robb GB, Millar A, Wang Y, Marsden PA. Translational regulation of human neuronal nitric-oxide synthase by an alternatively spliced 5'-untranslated region leader exon. The Journal of Biological Chemistry. 278: 636-44. PMID 12403769 DOI: 10.1074/jbc.M209988200  1
2002 Scott JA, Marsden PA, Slutsky AS. What lessons can we learn from NOS knockout mice in acute pulmonary disease? Critical Care Medicine. 30: 2143-5. PMID 12352056 DOI: 10.1097/01.CCM.0000027863.16345.79  1
2002 Levy GA, Marsden PA. Cigarette smoking--association with hepatic artery thrombosis. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. 8: 588-90. PMID 12089710 DOI: 10.1053/jlts.2002.34151  1
2002 Fan J, Kapus A, Marsden PA, Li YH, Oreopoulos G, Marshall JC, Frantz S, Kelly RA, Medzhitov R, Rotstein OD. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. Journal of Immunology (Baltimore, Md. : 1950). 168: 5252-9. PMID 11994482  1
2002 Chan CW, Chan MW, Liu M, Fung L, Cole EH, Leibowitz JL, Marsden PA, Clark DA, Levy GA. Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 5170-7. PMID 11994472  1
2002 Wang Y, Newton DC, Miller TL, Teichert AM, Phillips MJ, Davidoff MS, Marsden PA. An alternative promoter of the human neuronal nitric oxide synthase gene is expressed specifically in Leydig cells. The American Journal of Pathology. 160: 369-80. PMID 11786430 DOI: 10.1016/S0002-9440(10)64380-5  1
2001 Lorenzo MN, Khan RY, Wang Y, Tai SC, Chan GC, Cheung AH, Marsden PA. Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. Biochimica Et Biophysica Acta. 1522: 46-52. PMID 11718899 DOI: 10.1016/S0167-4781(01)00283-4  1
2001 Yuwaraj S, Ding J, Liu M, Marsden PA, Levy GA. Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: A novel human procoagulant Genomics. 71: 330-338. PMID 11170750 DOI: 10.1006/geno.2000.6444  1
2000 Levy GA, Liu M, Ding J, Yuwaraj S, Leibowitz J, Marsden PA, Ning Q, Kovalinka A, Phillips JM. Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis American Journal of Pathology. 156: 1217-1225. PMID 10751347  1
2000 Teichert AM, Miller TL, Tai SC, Wang Y, Bei X, Robb GB, Phillips MJ, Marsden PA. In vivo expression profile of an endothelial nitric oxide synthase promoter-reporter transgene. American Journal of Physiology. Heart and Circulatory Physiology. 278: H1352-61. PMID 10749733  1
1999 Wang Y, Newton DC, Robb GB, Kau CL, Miller TL, Cheung AH, Hall AV, VanDamme S, Wilcox JN, Marsden PA. RNA diversity has profound effects on the translation of neuronal nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 96: 12150-5. PMID 10518591 DOI: 10.1073/pnas.96.21.12150  1
1999 Marsden PA. Germline polymorphisms in cardiovascular medicine. Is that the whole story? Canadian Journal of Cardiology. 15. PMID 10350676  1
1999 Wang Y, Newton DC, Marsden PA. Neuronal NOS: gene structure, mRNA diversity, and functional relevance. Critical Reviews in Neurobiology. 13: 21-43. PMID 10223522  1
1999 Ning Q, Liu M, Kongkham P, Lai MMC, Marsden PA, Tseng J, Pereira B, Belyavskyi M, Leibowitz J, Phillips MJ, Levy G. The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene Journal of Biological Chemistry. 274: 9930-9936. PMID 10187767 DOI: 10.1074/jbc.274.15.9930  1
1999 Karantzoulis-Fegaras F, Antoniou H, Lai SL, Kulkarni G, D'Abreo C, Wong GK, Miller TL, Chan Y, Atkins J, Wang Y, Marsden PA. Characterization of the human endothelial nitric-oxide synthase promoter. The Journal of Biological Chemistry. 274: 3076-93. PMID 9915847 DOI: 10.1074/jbc.274.5.3076  1
1998 Teichert AM, Karantzoulis-Fegaras F, Wang Y, Mawji IA, Bei X, Gnanapandithen K, Marsden PA. Characterization of the murine endothelial nitric oxide synthase promoter. Biochimica Et Biophysica Acta. 1443: 352-7. PMID 9878824 DOI: 10.1016/S0167-4781(98)00236-X  1
1998 Verkoczy LK, Marsden PA, Berinstein NL. hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). European Journal of Immunology. 28: 2839-53. PMID 9754571 DOI: 10.1002/(SICI)1521-4141(199809)28:09<2839::AID-IMMU2839>3.0.CO;2-6  1
1998 Pope M, Marsden PA, Cole E, Sloan S, Fung LS, Ning Q, Ding JW, Leibowitz JL, Phillips MJ, Levy GA. Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide. Journal of Virology. 72: 7084-90. PMID 9696801  1
1998 Cheung AH, Stewart RJ, Marsden PA. Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): Regional localization of the human genes to 8q22.3-q23 and 8p23 Genomics. 48: 389-391. PMID 9545648 DOI: 10.1006/geno.1997.5207  1
1998 Bitzan MM, Wang Y, Lin J, Marsden PA. Verotoxin and ricin have novel effects on preproendothelin-1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium Journal of Clinical Investigation. 101: 372-382. PMID 9435309  1
1997 Wilcox JN, Subramanian RR, Sundell CL, Ross Tracey W, Pollock JS, Harrison DG, Marsden PA. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2479-2488. PMID 9409218  1
1997 Ding JW, Ning Q, Liu MF, Lai A, Leibowitz J, Peltekian KM, Cole EH, Fung LS, Holloway C, Marsden PA, Yeger H, Phillips MJ, Levy GA. Fulminant hepatic failure in murine hepatitis virus strain 3 infection: Tissue-specific expression of a novel fgl2 prothrombinase Journal of Virology. 71: 9223-9230. PMID 9371581  1
1997 Wang Y, Goligorsky MS, Lin M, Wilcox JN, Marsden PA. A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase Journal of Biological Chemistry. 272: 11392-11401. PMID 9111048 DOI: 10.1074/jbc.272.17.11392  1
1997 Zarrin AA, Fong I, Malkin L, Marsden PA, Berinstein NL. Cloning and Characterization of the Human Recombination Activating Gene 1 (RAG1) and RAG2 Promoter Regions Journal of Immunology. 159: 4382-4394.  1
1996 Marsden PA, Kurokawa K. Ions, lipids and peptides: Newer concepts challenge classic paradigms Current Opinion in Nephrology and Hypertension. 5: 1-3. PMID 8834154 DOI: 10.1097/00041552-199601000-00001  1
1996 Gnanapandithen K, Chen Z, Kau CL, Gorczynski RM, Marsden PA. Cloning and characterization of murine endothelial constitutive nitric oxide synthase Biochimica Et Biophysica Acta - Gene Structure and Expression. 1308: 103-106. PMID 8764825 DOI: 10.1016/0167-4781(96)00098-X  1
1996 Chen J, Myllärniemi M, Akyürek LM, Häyry P, Marsden PA, Paul LC. Identification of differentially expressed genes in rat aortic allograft vasculopathy American Journal of Pathology. 149: 597-611. PMID 8701998  1
1996 Wong GKT, Marsden PA. Nitric oxide synthases: Regulation in disease Nephrology Dialysis Transplantation. 11: 215-220. PMID 8649643  1
1996 Chung E, Curtis D, Chen G, Marsden PA, Twells R, Xu W, Gardiner M. Genetic evidence for the neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosis American Journal of Human Genetics. 58: 363-370. PMID 8571963  1
1996 Stewart RJ, Kashour TS, Marsden PA. Vascular endothelial platelet endothelial cell adhesion molecule-1 (PECAM-1) expression is decreased by TNF-α and IFN-γ: Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells Journal of Immunology. 156: 1221-1228. PMID 8558001  1
1996 Cheung AH, Marsden PA. [16] Structural characterization of human neuronal nitric oxide synthase gene: Methodologic approach to a complex transcription unit Methods in Neurosciences. 31: 184-196. DOI: 10.1016/S1043-9471(96)80019-X  1
1995 Flowers MA, Wang Y, Stewart RJ, Patel B, Marsden PA. Reciprocal regulation of endothelin-1 and endothelial constitutive NOS in proliferating endothelial cells American Journal of Physiology - Heart and Circulatory Physiology. 269. PMID 8594908  1
1995 Wang Y, Marsden PA. Nitric oxide synthases: gene structure and regulation Advances in Pharmacology (San Diego, Calif.). 34: 71-90. PMID 8562454  1
1995 Stewart RJ, Marsden PA. Biologic control of the tumor necrosis factor and interleukin-1 signaling cascade American Journal of Kidney Diseases. 25: 954-966. PMID 7771496 DOI: 10.1016/0272-6386(95)90582-0  1
1995 Wang Y, Marsden PA. Nitric oxide synthases: Biochemical and molecular regulation Current Opinion in Nephrology and Hypertension. 4: 12-22. PMID 7538022 DOI: 10.1097/00041552-199501000-00003  1
1995 Nakane M, Pollock JS, Klinghofer V, Basha F, Marsden PA, Hokari A, Ogura T, Esumi H, Carter GW. Functional expression of three isoforms of human nitric oxide synthase in baculovirus-infected insect cells. Biochemical and Biophysical Research Communications. 206: 511-7. PMID 7530001 DOI: 10.1006/bbrc.1995.1073  1
1995 Kurokawa K, Marsden PA. Milieu interieur and the kidney Current Opinion in Nephrology and Hypertension. 4: 9-11. DOI: 10.1097/00041552-199501000-00002  1
1994 Stewart RJ, Marsden PA. Vascular endothelial cell activation in models of vascular and glomerular injury Kidney International, Supplement. 45. PMID 8158895  1
1994 Flowers MA, Marsden PA. Expression of endothelin-1 and nitric oxide is coupled to endothelial phenotype, especially growth state Experimental Nephrology. 2: 115-126. PMID 8082003  1
1994 Kester M, Nowinski RJ, Holthöfer H, Marsden PA, Dunn MJ. Characterization of platelet-activating factor synthesis in glomerular endothelial cell lines Kidney International. 46: 1404-1412. PMID 7853801  1
1994 Hall AV, Antoniou H, Wang Y, Cheung AH, Arbus AM, Olson SL, Lu WC, Kau CL, Marsden PA. Structural organization of the human neuronal nitric oxide synthase gene (NOS1). The Journal of Biological Chemistry. 269: 33082-90. PMID 7528745  1
1994 McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms American Journal of Physiology - Heart and Circulatory Physiology. 267. PMID 7526714  1
1994 Marsden PA, Heng HHQ, Duff CL, Shi XM, Tsui LC, Hall AV. Localization of the Human Gene for Inducible Nitric Oxide Synthase (NOS2) to Chromosome 17q11.2-q12 Genomics. 19: 183-185. PMID 7514565 DOI: 10.1006/geno.1994.1039  1
1994 Brady HR, Lamas S, Papayianni A, Takata S, Matsubara M, Marsden PA. Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction American Journal of Physiology - Renal Physiology. 268.  1
1993 Balligand JL, Kelly RA, Marsden PA, Smith TW, Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system Proceedings of the National Academy of Sciences of the United States of America. 90: 347-351. PMID 7678347  1
1992 Marsden PA, Brenner BM. Transcriptional regulation of the endothelin-1 gene by TNF-α American Journal of Physiology - Cell Physiology. 262. PMID 1566813  1
1992 Kasinath BS, Fried TA, Davalath S, Marsden PA. Glomerular epithelial cells synthesize endothelin peptides American Journal of Pathology. 141: 279-283. PMID 1497086  1
1992 Brady HR, Spertini O, Jimenez W, Brenner BM, Marsden PA, Tedder TF. Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro Journal of Immunology. 149: 2437-2444. PMID 1382103  1
1992 Lamas S, Michel T, Collins T, Brenner BM, Marsden PA. Effects of interferon-γ on nitric oxide synthase activity and endothelin- 1 production by vascular endothelial cells Journal of Clinical Investigation. 90: 879-887. PMID 1381725  1
1992 Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S, Michel T. Molecular cloning and characterization of human endothelial nitric oxide synthase Febs Letters. 307: 287-293. PMID 1379542 DOI: 10.1016/0014-5793(92)80697-F  1
1992 Lamas S, Marsden PA, Li GK, Tempst P, Michel T. Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform Proceedings of the National Academy of Sciences of the United States of America. 89: 6348-6352. PMID 1378626  1
1992 Marsden PA, Sultan P, Cybulsky M, Gimbrone MA, Brenner BM, Collins T. Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells Bba - Gene Structure and Expression. 1129: 249-250. PMID 1339290 DOI: 10.1016/0167-4781(92)90499-P  1
1992 Brenner B, Marsden PA, Lamas S. Endothelium-derived regulators of the circulation Nefrologia. 12: 1-8.  1
1991 Marsden PA, Brenner BM. Nitric oxide and endothelins: Novel autocrine/paracrine regulators of the circulation Seminars in Nephrology. 11: 169-185. PMID 2034925  1
1991 Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. The Journal of Clinical Investigation. 88: 1054-7. PMID 1885767 DOI: 10.1172/JCI115367  1
1991 Marsden PA, Goligorsky MS, Brenner BM. Endothelial cell Biology in relation to current concepts of vessel wall structure and function Journal of the American Society of Nephrology. 1: 931-948. PMID 1883964  1
1991 Marsden PA, Dorfman DM, Collins T, Brenner BM, Orkin SH, Ballermann BJ. Regulated expression of endothelin 1 in glomerular capillary endothelial cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261. PMID 1858892  1
1991 Ballermann BJ, Marsden PA. Endothelium-derived vasoactive mediators and renal glomerular function Clinical and Investigative Medicine. 14: 508-517. PMID 1794204  1
1991 Denton MD, Marsden PA, Luscinskas FW, Brenner BM, Brady HR. Cytokine-induced phagocyte adhesion to human mesangial cells: Role of CD11/CD18 integrins and ICAM-1 American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261. PMID 1721495  1
1991 Lamas S, Michel T, Brenner BM, Marsden PA. Nitric oxidec synthesis in endothelial cells: Evidence for a pathway inducible by TNF-α American Journal of Physiology - Cell Physiology. 261. PMID 1656767  1
1990 Marsden PA, Brock TA, Ballermann BJ. Glomerular endothelial cells respond to calcium-mobilizing agonists with release of EDRF. The American Journal of Physiology. 258: F1295-303. PMID 2159719  1
1990 Marsden PA, Ballermann BJ. Tumor necrosis factor α activates soluble guanylate cyclase in bovine glomerular mesabgial cells via an L-arginine-dependent mechanism Journal of Experimental Medicine. 172: 1843-1852. PMID 1979590  1
1989 Martin ER, Marsden PA, Brenner BM, Ballermann BJ. Identification and characterization of endothelin binding sites in rat renal papillary and glomerular membranes Biochemical and Biophysical Research Communications. 162: 130-137. PMID 2546542 DOI: 10.1016/0006-291X(89)91972-4  1
1989 Marsden PA, Danthuluri NR, Brenner BM, Ballermann BJ, Brock TA. Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization. Biochemical and Biophysical Research Communications. 158: 86-93. PMID 2536280 DOI: 10.1016/S0006-291X(89)80180-9  1
1987 Zettle RM, West ML, Josse RG, Richardson RM, Marsden PA, Halperin ML. Renal potassium handling during states of low aldosterone bio-activity: a method to differentiate renal and non-renal causes. American Journal of Nephrology. 7: 360-6. PMID 2829626  1
1986 West ML, Marsden PA, Singer GG, Halperin ML. Quantitative analysis of glucose loss during acute therapy for hyperglycemic hyperosmolar syndrome Diabetes Care. 9: 465-471. PMID 3769716  1
1986 West ML, Marsden PA, Richardson RM, Zettle RM, Halperin ML. New clinical approach to evaluate disorders of potassium excretion. Mineral and Electrolyte Metabolism. 12: 234-8. PMID 3762510  1
1986 Goldstein MB, Bear R, Richardson RMA, Marsden PA, Halperin ML. The urine anion gap: A clinically useful index of ammonium excretion American Journal of the Medical Sciences. 292: 198-202. PMID 3752165  1
1985 Halperin ML, Marsden PA, Singer GG, West ML. Can marked hyperglycemia occur without ketosis Clinical and Investigative Medicine. 8: 253-256. PMID 4075614  1
1985 Marsden PA, Halperin ML. Pathophysiological approach to patients presenting with hypernatremia American Journal of Nephrology. 5: 229-235. PMID 4050884  1
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