Gordon Keller - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Human Development, Molecular Biology, General Biophysics

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, et al. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 545: 432-438. PMID 28514439 DOI: 10.1038/nature22370  0.36
2016 Ditadi A, Sturgeon CM, Keller G. A view of human haematopoietic development from the Petri dish. Nature Reviews. Molecular Cell Biology. PMID 27876786 DOI: 10.1038/nrm.2016.127  0.36
2015 Fernandes S, Chong JJ, Paige SL, Iwata M, Torok-Storb B, Keller G, Reinecke H, Murry CE. Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Stem Cell Reports. PMID 26607951 DOI: 10.1016/j.stemcr.2015.09.011  0.36
2015 Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, ... ... Keller G, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nature Medicine. PMID 26501191 DOI: 10.1038/nm.3973  0.36
2015 Holtzinger A, Streeter PR, Sarangi F, Hillborn S, Niapour M, Ogawa S, Keller G. New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells. Development (Cambridge, England). PMID 26493401 DOI: 10.1242/dev.121020  0.36
2015 Li LB, Ma C, Awong G, Kennedy M, Gornalusse G, Keller G, Kaufman DS, Russell DW. Silent IL2RG Gene Editing in Human Pluripotent Stem Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26444081 DOI: 10.1038/mt.2015.190  0.36
2015 Clarke RL, Robitaille AM, Moon RT, Keller G. A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17. Stem Cell Reports. 5: 291-304. PMID 26267830 DOI: 10.1016/j.stemcr.2015.07.008  0.36
2015 Craft AM, Rockel JS, Nartiss Y, Kandel RA, Alman BA, Keller GM. Generation of articular chondrocytes from human pluripotent stem cells. Nature Biotechnology. 33: 638-45. PMID 25961409 DOI: 10.1038/nbt.3210  0.36
2015 Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nature Cell Biology. 17: 580-91. PMID 25915127 DOI: 10.1038/ncb3161  0.36
2015 Amer LD, Holtzinger A, Keller G, Mahoney MJ, Bryant SJ. Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates. Acta Biomaterialia. 22: 103-10. PMID 25913222 DOI: 10.1016/j.actbio.2015.04.013  0.36
2015 Ruan JL, Tulloch NL, Saiget M, Paige SL, Razumova MV, Regnier M, Tung KC, Keller G, Pabon L, Reinecke H, Murry CE. Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors. Stem Cells (Dayton, Ohio). 33: 2148-57. PMID 25865043 DOI: 10.1002/stem.2036  0.36
2015 Nostro MC, Sarangi F, Yang C, Holland A, Elefanty AG, Stanley EG, Greiner DL, Keller G. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 4: 591-604. PMID 25843049 DOI: 10.1016/j.stemcr.2015.02.017  0.36
2014 Prowse AB, Timmins NE, Yau TM, Li RK, Weisel RD, Keller G, Zandstra PW. Transforming the promise of pluripotent stem cell-derived cardiomyocytes to a therapy: challenges and solutions for clinical trials. The Canadian Journal of Cardiology. 30: 1335-49. PMID 25442434 DOI: 10.1016/j.cjca.2014.08.005  0.36
2014 Witty AD, Mihic A, Tam RY, Fisher SA, Mikryukov A, Shoichet MS, Li RK, Kattman SJ, Keller G. Generation of the epicardial lineage from human pluripotent stem cells. Nature Biotechnology. 32: 1026-35. PMID 25240927 DOI: 10.1038/nbt.3002  0.36
2014 Sturgeon CM, Ditadi A, Awong G, Kennedy M, Keller G. Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. Nature Biotechnology. 32: 554-61. PMID 24837661 DOI: 10.1038/nbt.2915  0.36
2014 Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons C, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab On a Chip. 14: 869-82. PMID 24352498 DOI: 10.1039/c3lc51123e  0.36
2013 Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proceedings of the National Academy of Sciences of the United States of America. 110: E4698-707. PMID 24255110 DOI: 10.1073/pnas.1311120110  0.36
2013 Chanda B, Ditadi A, Iscove NN, Keller G. Retinoic acid signaling is essential for embryonic hematopoietic stem cell development. Cell. 155: 215-27. PMID 24074870 DOI: 10.1016/j.cell.2013.08.055  0.36
2013 Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori KS, Wang S, Tamblyn L, Guillemette C, Hoffmann E, Zhao B, Strom S, Laposa RR, Tyndale RF, Grant DM, ... Keller G, et al. Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development (Cambridge, England). 140: 3285-96. PMID 23861064 DOI: 10.1242/dev.090266  0.36
2013 Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Massé S, Gagliardi M, Hsieh A, Thavandiran N, Laflamme MA, Nanthakumar K, Gross GJ, Backx PH, ... Keller G, et al. Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nature Methods. 10: 781-7. PMID 23793239 DOI: 10.1038/nmeth.2524  0.36
2013 Craft AM, Ahmed N, Rockel JS, Baht GS, Alman BA, Kandel RA, Grigoriadis AE, Keller GM. Specification of chondrocytes and cartilage tissues from embryonic stem cells. Development (Cambridge, England). 140: 2597-610. PMID 23715552 DOI: 10.1242/dev.087890  0.36
2013 Sturgeon CM, Ditadi A, Clarke RL, Keller G. Defining the path to hematopoietic stem cells. Nature Biotechnology. 31: 416-8. PMID 23657396 DOI: 10.1038/nbt.2571  0.36
2013 Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. The expression of Sox17 identifies and regulates haemogenic endothelium. Nature Cell Biology. 15: 502-10. PMID 23604320 DOI: 10.1038/ncb2724  0.36
2013 Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, ... ... Keller G, et al. Parthenogenetic stem cells for tissue-engineered heart repair. The Journal of Clinical Investigation. 123: 1285-98. PMID 23434590 DOI: 10.1172/JCI66854  0.36
2013 Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW, Li RA. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circulation. Arrhythmia and Electrophysiology. 6: 191-201. PMID 23392582 DOI: 10.1161/CIRCEP.111.973420  0.36
2013 Terrenoire C, Wang K, Tung KW, Chung WK, Pass RH, Lu JT, Jean JC, Omari A, Sampson KJ, Kotton DN, Keller G, Kass RS. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. The Journal of General Physiology. 141: 61-72. PMID 23277474 DOI: 10.1085/jgp.201210899  0.36
2012 Kennedy M, Awong G, Sturgeon CM, Ditadi A, LaMotte-Mohs R, Zúñiga-Pflücker JC, Keller G. T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Reports. 2: 1722-35. PMID 23219550 DOI: 10.1016/j.celrep.2012.11.003  0.36
2012 Paige SL, Thomas S, Stoick-Cooper CL, Wang H, Maves L, Sandstrom R, Pabon L, Reinecke H, Pratt G, Keller G, Moon RT, Stamatoyannopoulos J, Murry CE. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell. 151: 221-32. PMID 22981225 DOI: 10.1016/j.cell.2012.08.027  0.36
2012 Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell. 11: 23-35. PMID 22770240 DOI: 10.1016/j.stem.2012.03.016  0.36
2012 Sturgeon CM, Chicha L, Ditadi A, Zhou Q, McGrath KE, Palis J, Hammond SM, Wang S, Olson EN, Keller G. Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells. Developmental Cell. 23: 45-57. PMID 22749417 DOI: 10.1016/j.devcel.2012.05.021  0.36
2012 Ungrin MD, Clarke G, Yin T, Niebrugge S, Nostro MC, Sarangi F, Wood G, Keller G, Zandstra PW. Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics. Biotechnology and Bioengineering. 109: 853-66. PMID 22139975 DOI: 10.1002/bit.24375  0.36
2011 Fu JD, Rushing SN, Lieu DK, Chan CW, Kong CW, Geng L, Wilson KD, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Hajjar RJ, Li RA. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. Plos One. 6: e27417. PMID 22110643 DOI: 10.1371/journal.pone.0027417  0.36
2011 Wang K, Terrenoire C, Sampson KJ, Iyer V, Osteen JD, Lu J, Keller G, Kotton DN, Kass RS. Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. The Journal of Physiology. 589: 6093-104. PMID 22025662 DOI: 10.1113/jphysiol.2011.220863  0.36
2011 Dubois NC, Craft AM, Sharma P, Elliott DA, Stanley EG, Elefanty AG, Gramolini A, Keller G. SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nature Biotechnology. 29: 1011-8. PMID 22020386 DOI: 10.1038/nbt.2005  0.36
2011 Zhang X, Yalcin S, Lee DF, Yeh TY, Lee SM, Su J, Mungamuri SK, Rimmelé P, Kennedy M, Sellers R, Landthaler M, Tuschl T, Chi NW, Lemischka I, Keller G, et al. FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nature Cell Biology. 13: 1092-9. PMID 21804543 DOI: 10.1038/ncb2293  0.36
2011 Han S, Dziedzic N, Gadue P, Keller GM, Gouon-Evans V. An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling. Stem Cells (Dayton, Ohio). 29: 217-28. PMID 21732480 DOI: 10.1002/stem.576  0.36
2011 Green MD, Chen A, Nostro MC, d'Souza SL, Schaniel C, Lemischka IR, Gouon-Evans V, Keller G, Snoeck HW. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nature Biotechnology. 29: 267-72. PMID 21358635 DOI: 10.1038/nbt.1788  0.36
2011 Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (Cambridge, England). 138: 861-71. PMID 21270052 DOI: 10.1242/dev.055236  0.36
2010 DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. Plos One. 5: e13039. PMID 20885963 DOI: 10.1371/journal.pone.0013039  0.36
2010 Irion S, Clarke RL, Luche H, Kim I, Morrison SJ, Fehling HJ, Keller GM. Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development (Cambridge, England). 137: 2829-39. PMID 20659975 DOI: 10.1242/dev.042119  0.36
2010 Grigoriadis AE, Kennedy M, Bozec A, Brunton F, Stenbeck G, Park IH, Wagner EF, Keller GM. Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood. 115: 2769-76. PMID 20065292 DOI: 10.1182/blood-2009-07-234690  0.36
2010 Song H, Yoon C, Kattman SJ, Dengler J, Massé S, Thavaratnam T, Gewarges M, Nanthakumar K, Rubart M, Keller GM, Radisic M, Zandstra PW. Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proceedings of the National Academy of Sciences of the United States of America. 107: 3329-34. PMID 19846783 DOI: 10.1073/pnas.0905729106  0.36
2009 Adler ED, Bystrup A, Briley-Saebo KC, Mani V, Young W, Giovanonne S, Altman P, Kattman SJ, Frank JA, Weinmann HJ, Keller GM, Fayad ZA. In vivo detection of embryonic stem cell-derived cardiovascular progenitor cells using Cy3-labeled Gadofluorine M in murine myocardium. Jacc. Cardiovascular Imaging. 2: 1114-22. PMID 19761992 DOI: 10.1016/j.jcmg.2009.04.015  0.36
2009 Gadue P, Gouon-Evans V, Cheng X, Wandzioch E, Zaret KS, Grompe M, Streeter PR, Keller GM. Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. Stem Cells (Dayton, Ohio). 27: 2103-13. PMID 19522011 DOI: 10.1002/stem.147  0.36
2009 Henckaerts E, Dutheil N, Zeltner N, Kattman S, Kohlbrenner E, Ward P, Clément N, Rebollo P, Kennedy M, Keller GM, Linden RM. Site-specific integration of adeno-associated virus involves partial duplication of the target locus. Proceedings of the National Academy of Sciences of the United States of America. 106: 7571-6. PMID 19372372 DOI: 10.1073/pnas.0806821106  0.36
2009 Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 4: 198-9; author reply . PMID 19265656 DOI: 10.1016/j.stem.2009.02.010  0.36
2008 Chen VC, Stull R, Joo D, Cheng X, Keller G. Notch signaling respecifies the hemangioblast to a cardiac fate. Nature Biotechnology. 26: 1169-78. PMID 18820686 DOI: 10.1038/nbt.1497  0.36
2008 Cheng X, Huber TL, Chen VC, Gadue P, Keller GM. Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (Cambridge, England). 135: 3447-58. PMID 18799543 DOI: 10.1242/dev.025916  0.36
2008 Mani V, Adler E, Briley-Saebo KC, Bystrup A, Fuster V, Keller G, Fayad ZA. Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 60: 73-81. PMID 18581415 DOI: 10.1002/mrm.21642  0.36
2008 Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 453: 524-8. PMID 18432194 DOI: 10.1038/nature06894  0.36
2008 Nostro MC, Cheng X, Keller GM, Gadue P. Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell. 2: 60-71. PMID 18371422 DOI: 10.1016/j.stem.2007.10.011  0.36
2007 Kattman SJ, Adler ED, Keller GM. Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development. Trends in Cardiovascular Medicine. 17: 240-6. PMID 17936206 DOI: 10.1016/j.tcm.2007.08.004  0.36
2007 Kennedy M, D'Souza SL, Lynch-Kattman M, Schwantz S, Keller G. Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood. 109: 2679-87. PMID 17148580 DOI: 10.1182/blood-2006-09-047704  0.36
2007 Zafonte BT, Liu S, Lynch-Kattman M, Torregroza I, Benvenuto L, Kennedy M, Keller G, Evans T. Smad1 expands the hemangioblast population within a limited developmental window. Blood. 109: 516-23. PMID 16990609 DOI: 10.1182/blood-2006-02-004564  0.36
2006 Gadue P, Huber TL, Paddison PJ, Keller GM. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 16806-11. PMID 17077151 DOI: 10.1073/pnas.0603916103  0.36
2006 Germano IM, Uzzaman M, Benveniste RJ, Zaurova M, Keller G. Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand. Journal of Neurosurgery. 105: 88-95. PMID 16871882 DOI: 10.3171/jns.2006.105.1.88  0.36
2006 Willey S, Ayuso-Sacido A, Zhang H, Fraser ST, Sahr KE, Adlam MJ, Kyba M, Daley GQ, Keller G, Baron MH. Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor. Blood. 107: 3122-30. PMID 16403910 DOI: 10.1182/blood-2005-10-4120  0.36
2005 Uzzaman M, Benveniste RJ, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: a novel gene therapy vector for brain tumors. Neurosurgical Focus. 19: E6. PMID 16190605  0.36
2005 Gadue P, Huber TL, Nostro MC, Kattman S, Keller GM. Germ layer induction from embryonic stem cells. Experimental Hematology. 33: 955-64. PMID 16140142 DOI: 10.1016/j.exphem.2005.06.009  0.36
2005 Benveniste RJ, Keller G, Germano I. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: differentiation and transplantion into the mouse brain. Journal of Neurosurgery. 103: 115-23. PMID 16121982 DOI: 10.3171/jns.2005.103.1.0115  0.36
2005 D'Souza SL, Elefanty AG, Keller G. SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood. 105: 3862-70. PMID 15677567 DOI: 10.1182/blood-2004-09-3611  0.36
1995 Keller GM. In vitro differentiation of embryonic stem cells Current Opinion in Cell Biology. 7: 862-869. PMID 8608017 DOI: 10.1016/0955-0674(95)80071-9  0.36
1992 Keller G. Hematopoietic stem cells Current Opinion in Immunology. 4: 133-139. PMID 1605905 DOI: 10.1016/0952-7915(92)90002-V  0.36
1992 Keller G. Clonal analysis of hematopoietic stem cell development in vivo Current Topics in Microbiology and Immunology. 177: 41-57. PMID 1353433  0.36
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