Cheryl Arrowsmith - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
General Biophysics, Biochemistry

231 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kaustov L, Lemak A, Wu H, Faini M, Fan L, Fang X, Zeng H, Duan S, Allali-Hassani A, Li F, Wei Y, Vedadi M, Aebersold R, Wang Y, Houliston S, ... Arrowsmith CH, et al. The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions. Nucleic Acids Research. PMID 31400120 DOI: 10.1093/nar/gkz697  0.32
2019 Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless VB, Liew SK, Houliston SR, De Freitas RF, Smil D, Sena CCD, Kennedy S, Diaz DB, Wu H, Dombrovski L, ... ... Arrowsmith CH, et al. Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Bioorganic & Medicinal Chemistry. PMID 31327677 DOI: 10.1016/j.bmc.2019.07.020  0.4
2019 Halabelian L, Ravichandran M, Li Y, Zeng H, Rao A, Aravind L, Arrowsmith CH. Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Nature Structural & Molecular Biology. PMID 31235913 DOI: 10.1038/s41594-019-0246-6  0.32
2019 Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, ... Arrowsmith CH, et al. A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Communications. 10: 1915. PMID 31015424 DOI: 10.1038/s41467-019-09672-2  0.32
2019 Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, ... ... Arrowsmith CH, et al. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nature Communications. 10: 1436. PMID 30926792 DOI: 10.1038/s41467-019-09309-4  0.32
2019 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, ... ... Arrowsmith CH, et al. Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 30842648 DOI: 10.1038/s41589-019-0242-5  0.4
2018 Ivanochko D, Halabelian L, Henderson E, Savitsky P, Jain H, Marcon E, Duan S, Hutchinson A, Seitova A, Barsyte-Lovejoy D, Filippakopoulos P, Greenblatt J, Lima-Fernandes E, Arrowsmith CH. Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Research. PMID 30462309 DOI: 10.1093/nar/gky1192  0.32
2018 Ferreira de Freitas R, Harding RJ, Franzoni I, Ravichandran M, Mann MK, Ouyang H, Lautens M, Santhakumar V, Arrowsmith CH, Schapira M. Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. Journal of Medicinal Chemistry. PMID 29741882 DOI: 10.1021/acs.jmedchem.8b00258  0.32
2017 Houliston RS, Lemak A, Iqbal A, Ivanochko D, Duan S, Kaustov L, Ong MS, Fan L, Senisterra G, Brown PJ, Wang YX, Arrowsmith CH. Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability. The Journal of Biological Chemistry. PMID 29074623 DOI: 10.1074/jbc.M117.799700  0.32
2017 Harding RJ, Ferreira de Freitas R, Collins PM, Franzoni I, Ravichandran M, Ouyang H, Juarez-Ornelas KA, Lautens M, Schapira M, von Delft F, Santhakumar V, Arrowsmith CH. Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin. Journal of Medicinal Chemistry. PMID 29019676 DOI: 10.1021/acs.jmedchem.7b00933  0.32
2017 Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE. The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage. Elife. 6. PMID 28406400 DOI: 10.7554/eLife.23872  0.32
2016 Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin J. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. Journal of Medicinal Chemistry. PMID 27804297 DOI: 10.1021/acs.jmedchem.6b01244  0.32
2016 Shen Y, Szewczyk MM, Eram MS, Smil D, Kaniskan HÜ, de Freitas RF, Senisterra G, Li F, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J. Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry. PMID 27584694 DOI: 10.1021/acs.jmedchem.6b01033  1
2016 Kagoya Y, Nakatsugawa M, Yamashita Y, Ochi T, Guo T, Anczurowski M, Saso K, Butler MO, Arrowsmith CH, Hirano N. BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models. The Journal of Clinical Investigation. PMID 27548527 DOI: 10.1172/JCI86437  1
2016 Yang X, Li F, Konze KD, Meslamani J, Ma A, Brown PJ, Zhou MM, Arrowsmith CH, Kaniskan HÜ, Vedadi M, Jin J. Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors. Journal of Medicinal Chemistry. PMID 27468126 DOI: 10.1021/acs.jmedchem.6b00855  1
2016 Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of Medicinal Chemistry. PMID 27390919 DOI: 10.1021/acs.jmedchem.6b00668  1
2016 Schapira M, Arrowsmith CH. Methyltransferase inhibitors for modulation of the epigenome and beyond. Current Opinion in Chemical Biology. 33: 81-87. PMID 27318562 DOI: 10.1016/j.cbpa.2016.05.030  1
2016 Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, ... ... Arrowsmith CH, et al. Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nature Structural & Molecular Biology. PMID 27294782 DOI: 10.1038/nsmb.3249  1
2016 Ahmed H, Duan S, Arrowsmith CH, Barsyte-Lovejoy D, Schapira M. An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates. Journal of Proteome Research. PMID 27163177 DOI: 10.1021/acs.jproteome.6b00220  1
2016 Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M. PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase. The Journal of Biological Chemistry. PMID 27129774 DOI: 10.1074/jbc.M116.721472  1
2016 Oudhoff MJ, Braam MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, et al. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling. Developmental Cell. 37: 47-57. PMID 27046831 DOI: 10.1016/j.devcel.2016.03.002  1
2016 Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut P, Kaznowska EB, Arrowsmith CH, Khatri P, Stresemann C, Gozani O, Sage J. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes & Development. PMID 26988419 DOI: 10.1101/gad.275529.115  1
2016 Getlik M, Smil D, Zepeda-Velázquez C, Bolshan Y, Poda G, Wu H, Dong A, Kuznetsova E, Marcellus R, Senisterra G, Dombrovski L, Hajian T, Kiyota T, Schapira M, Arrowsmith CH, et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry. PMID 26958703 DOI: 10.1021/acs.jmedchem.5b01630  1
2016 Ferreira de Freitas R, Eram MS, Szewczyk MM, Steuber H, Smil D, Wu H, Li F, Senisterra G, Dong A, Brown PJ, Hitchcock M, Moosmayer D, Stegmann CM, Egner U, Arrowsmith C, et al. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of Medicinal Chemistry. PMID 26824386 DOI: 10.1021/acs.jmedchem.5b01772  1
2016 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, ... ... Arrowsmith CH, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 26807715 DOI: 10.1038/nchembio.2007  1
2015 Li F, Kennedy S, Hajian T, Gibson E, Seitova A, Xu C, Arrowsmith CH, Vedadi M. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Journal of Biomolecular Screening. PMID 26701100 DOI: 10.1177/1087057115623264  1
2015 Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, ... ... Arrowsmith CH, et al. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. Cancer Cell. PMID 26626085 DOI: 10.1016/j.ccell.2015.10.005  1
2015 Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, et al. A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases. Acs Chemical Biology. PMID 26598975 DOI: 10.1021/acschembio.5b00839  1
2015 Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nature Medicine. PMID 26501191 DOI: 10.1038/nm.3973  1
2015 Sun Y, Bell JL, Carter DR, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, ... ... Arrowsmith CH, et al. WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma. Cancer Research. PMID 26471359 DOI: 10.1158/0008-5472.CAN-15-0423  1
2015 Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, ... ... Arrowsmith CH, et al. Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. Plos One. 10: e0139695. PMID 26437229 DOI: 10.1371/journal.pone.0139695  1
2015 Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 525: 206-11. PMID 26331536 DOI: 10.1038/nature15251  1
2015 Everett J, Tejero R, Murthy SB, Acton TB, Aramini JM, Baran MC, Benach J, Cort JR, Eletsky A, Forouhar F, Guan R, Kuzin AP, Lee HW, Liu G, Mani R, ... ... Arrowsmith CH, et al. A Community Resource of Experimental Data for NMR - X-ray Crystal Structure Pairs. Protein Science : a Publication of the Protein Society. PMID 26293815 DOI: 10.1002/pro.2774  1
2015 Pozhidaeva AK, Mohni KN, Dhe-Paganon S, Arrowsmith CH, Weller SK, Korzhnev DM, Bezsonova I. Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1. The Journal of Biological Chemistry. 290: 22907-18. PMID 26224631 DOI: 10.1074/jbc.M115.664805  1
2015 Huston A, Arrowsmith CH, Knapp S, Schapira M. Probing the epigenome. Nature Chemical Biology. 11: 542-5. PMID 26196765 DOI: 10.1038/nchembio.1871  1
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/nchembio.1867  1
2015 Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, ... ... Arrowsmith CH, et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology. 11: 571-8. PMID 26167872 DOI: 10.1038/nchembio.1859  1
2015 Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, ... ... Arrowsmith CH, et al. Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods. PMID 26121405 DOI: 10.1038/nmeth.3472  1
2015 Sweis RF, Wang Z, Algire M, Arrowsmith CH, Brown PJ, Chiang GG, Guo J, Jakob CG, Kennedy S, Li F, Maag D, Shaw B, Soni NB, Vedadi M, Pappano WN. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. Acs Medicinal Chemistry Letters. 6: 695-700. PMID 26101576 DOI: 10.1021/acsmedchemlett.5b00124  1
2015 Rosato A, Vranken W, Fogh RH, Ragan TJ, Tejero R, Pederson K, Lee HW, Prestegard JH, Yee A, Wu B, Lemak A, Houliston S, Arrowsmith CH, Kennedy M, Acton TB, et al. The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013. Journal of Biomolecular Nmr. PMID 26071966 DOI: 10.1007/s10858-015-9953-4  1
2015 Eram MS, Kuznetsova E, Li F, Lima-Fernandes E, Kennedy S, Chau I, Arrowsmith CH, Schapira M, Vedadi M. Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2. Biochimica Et Biophysica Acta. 1850: 1842-8. PMID 26002201 DOI: 10.1016/j.bbagen.2015.05.013  1
2015 Buchko GW, Yee A, Semesi A, Myler PJ, Arrowsmith CH, Hui R. Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum. Acta Crystallographica. Section F, Structural Biology Communications. 71: 514-21. PMID 25945703 DOI: 10.1107/S2053230X1402799X  1
2015 Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Dual PRMT5-PRMT7 Inhibitor. Acs Medicinal Chemistry Letters. 6: 408-12. PMID 25893041 DOI: 10.1021/ml500467h  1
2015 Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen LH, Curtis C, Emtage S, Fan L, Gheyi T, Li F, Liu S, Martin JR, Mendel D, Olsen JB, Pelletier L, ... ... Arrowsmith CH, et al. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. The Journal of Biological Chemistry. 290: 13641-53. PMID 25825497 DOI: 10.1074/jbc.M114.626861  1
2015 Tardat M, Albert M, Kunzmann R, Liu Z, Kaustov L, Thierry R, Duan S, Brykczynska U, Arrowsmith CH, Peters AH. Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner. Molecular Cell. 58: 157-71. PMID 25801166 DOI: 10.1016/j.molcel.2015.02.013  1
2015 Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, ... ... Arrowsmith CH, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International Ed. in English). 54: 5166-70. PMID 25728001 DOI: 10.1002/anie.201412154  1
2015 Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M. Preclinical target validation using patient-derived cells. Nature Reviews. Drug Discovery. 14: 149-50. PMID 25722227 DOI: 10.1038/nrd4565  1
2015 Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. Acs Chemical Biology. 10: 1072-81. PMID 25590533 DOI: 10.1021/cb500956g  1
2015 Hong JH, Kaustov L, Coyaud E, Srikumar T, Wan J, Arrowsmith C, Raught B. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. Molecular & Cellular Proteomics : McP. 14: 674-85. PMID 25582440 DOI: 10.1074/mcp.M114.042168  1
2014 Dong C, Zhang H, Xu C, Arrowsmith CH, Min J. Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation. Iucrj. 1: 540-9. PMID 25485134 DOI: 10.1107/S2052252514020922  1
2014 Lemak A, Wu B, Yee A, Houliston S, Lee HW, Gutmanas A, Fang X, Garcia M, Semesi A, Wang YX, Prestegard JH, Arrowsmith CH. Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data. Structure (London, England : 1993). 22: 1862-74. PMID 25456817 DOI: 10.1016/j.str.2014.09.013  1
2014 Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, ... ... Arrowsmith CH, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 12853-8. PMID 25136132 DOI: 10.1073/pnas.1407358111  1
2014 Ma A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin J. Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Journal of Medicinal Chemistry. 57: 6822-33. PMID 25032507 DOI: 10.1021/jm500871s  1
2014 Eletsky A, Michalska K, Houliston S, Zhang Q, Daily MD, Xu X, Cui H, Yee A, Lemak A, Wu B, Garcia M, Burnet MC, Meyer KM, Aryal UK, Sanchez O, ... ... Arrowsmith CH, et al. Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO. Plos One. 9: e101787. PMID 25010333 DOI: 10.1371/journal.pone.0101787  1
2014 Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, ... ... Arrowsmith CH, et al. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nature Structural & Molecular Biology. 21: 686-95. PMID 24997600 DOI: 10.1038/nsmb.2853  1
2014 Gelato KA, Tauber M, Ong MS, Winter S, Hiragami-Hamada K, Sindlinger J, Lemak A, Bultsma Y, Houliston S, Schwarzer D, Divecha N, Arrowsmith CH, Fischle W. Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. Molecular Cell. 54: 905-19. PMID 24813945 DOI: 10.1016/j.molcel.2014.04.004  1
2014 Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, ... Arrowsmith CH, et al. Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. The Journal of Clinical Investigation. 124: 1945-55. PMID 24667637 DOI: 10.1172/JCI69592  1
2014 Helander S, Montecchio M, Lemak A, Farès C, Almlöf J, Li Y, Yee A, Arrowsmith CH, Dhe-Paganon S, Sunnerhagen M. Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1. Biochemical and Biophysical Research Communications. 447: 26-31. PMID 24667607 DOI: 10.1016/j.bbrc.2014.03.068  1
2014 Eram MS, Bustos SP, Lima-Fernandes E, Siarheyeva A, Senisterra G, Hajian T, Chau I, Duan S, Wu H, Dombrovski L, Schapira M, Arrowsmith CH, Vedadi M. Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. The Journal of Biological Chemistry. 289: 12177-88. PMID 24634223 DOI: 10.1074/jbc.M113.523183  1
2014 Yee AA, Semesi A, Garcia M, Arrowsmith CH. Screening proteins for NMR suitability. Methods in Molecular Biology (Clifton, N.J.). 1140: 169-78. PMID 24590717 DOI: 10.1007/978-1-4939-0354-2_13  1
2014 Grondin JM, Chitayat S, Ficko-Blean E, Houliston S, Arrowsmith CH, Boraston AB, Smith SP. An unusual mode of galactose recognition by a family 32 carbohydrate-binding module. Journal of Molecular Biology. 426: 869-80. PMID 24326248 DOI: 10.1016/j.jmb.2013.11.029  1
2014 Kreso A, van Galen P, Pedley NM, Lima-Fernandes E, Frelin C, Davis T, Cao L, Baiazitov R, Du W, Sydorenko N, Moon YC, Gibson L, Wang Y, Leung C, Iscove NN, ... Arrowsmith CH, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nature Medicine. 20: 29-36. PMID 24292392 DOI: 10.1038/nm.3418  1
2014 Watson M, Chow S, Barsyte D, Arrowsmith C, Shankey TV, Minden M, Hedley D. The study of epigenetic mechanisms based on the analysis of histone modification patterns by flow cytometry. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 85: 78-87. PMID 24038859 DOI: 10.1002/cyto.a.22344  1
2013 Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface. Medchemcomm. 4: 1501-1507. PMID 24466405 DOI: 10.1039/C3MD00197K  1
2013 Wu H, Zeng H, Dong A, Li F, He H, Senisterra G, Seitova A, Duan S, Brown PJ, Vedadi M, Arrowsmith CH, Schapira M. Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One. 8: e83737. PMID 24367611 DOI: 10.1371/journal.pone.0083737  1
2013 Lemak A, Yee A, Wu H, Yap D, Zeng H, Dombrovski L, Houliston S, Aparicio S, Arrowsmith CH. Solution NMR structure and histone binding of the PHD domain of human MLL5. Plos One. 8: e77020. PMID 24130829 DOI: 10.1371/journal.pone.0077020  1
2013 Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of Medicinal Chemistry. 56: 8931-42. PMID 24102134 DOI: 10.1021/jm401480r  1
2013 James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. Journal of Medicinal Chemistry. 56: 7358-71. PMID 24040942 DOI: 10.1021/jm400919p  1
2013 Pocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G. The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. Plos One. 8: e72446. PMID 24039764 DOI: 10.1371/journal.pone.0072446  1
2013 Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, et al. Control of the hippo pathway by Set7-dependent methylation of Yap. Developmental Cell. 26: 188-94. PMID 23850191 DOI: 10.1016/j.devcel.2013.05.025  1
2013 Rothbart SB, Dickson BM, Ong MS, Krajewski K, Houliston S, Kireev DB, Arrowsmith CH, Strahl BD. Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes & Development. 27: 1288-98. PMID 23752590 DOI: 10.1101/gad.220467.113  1
2013 Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, ... ... Arrowsmith CH, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34. PMID 23614352 DOI: 10.1021/cb400133j  1
2013 Sarkari F, Wheaton K, La Delfa A, Mohamed M, Shaikh F, Khatun R, Arrowsmith CH, Frappier L, Saridakis V, Sheng Y. Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1. The Journal of Biological Chemistry. 288: 16975-85. PMID 23603909 DOI: 10.1074/jbc.M113.469262  1
2013 Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Journal of Medicinal Chemistry. 56: 2110-24. PMID 23445220 DOI: 10.1021/jm3018332  1
2013 Yu W, Smil D, Li F, Tempel W, Fedorov O, Nguyen KT, Bolshan Y, Al-Awar R, Knapp S, Arrowsmith CH, Vedadi M, Brown PJ, Schapira M. Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorganic & Medicinal Chemistry. 21: 1787-94. PMID 23433670 DOI: 10.1016/j.bmc.2013.01.049  1
2013 Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Molecular Endocrinology (Baltimore, Md.). 27: 315-24. PMID 23322723 DOI: 10.1210/me.2012-1287  1
2013 James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, ... ... Arrowsmith CH, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature Chemical Biology. 9: 184-91. PMID 23292653 DOI: 10.1038/nchembio.1157  1
2013 Williams DE, Dalisay DS, Li F, Amphlett J, Maneerat W, Chavez MA, Wang YA, Matainaho T, Yu W, Brown PJ, Arrowsmith CH, Vedadi M, Andersen RJ. Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Organic Letters. 15: 414-7. PMID 23272941 DOI: 10.1021/ol303416k  1
2013 Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Dong A, Nguyen KT, Smil D, Bolshan Y, Hajian T, He H, Seitova A, Chau I, Li F, ... ... Arrowsmith CH, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. The Biochemical Journal. 449: 151-9. PMID 22989411 DOI: 10.1042/BJ20121280  1
2012 Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, ... ... Arrowsmith CH, et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nature Communications. 3: 1288. PMID 23250418 DOI: 10.1038/ncomms2304  1
2012 Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature Structural & Molecular Biology. 19: 1155-60. PMID 23022729 DOI: 10.1038/nsmb.2391  1
2012 Nady N, Krichevsky L, Zhong N, Duan S, Tempel W, Amaya MF, Ravichandran M, Arrowsmith CH. Histone recognition by human malignant brain tumor domains. Journal of Molecular Biology. 423: 702-18. PMID 22954662 DOI: 10.1016/j.jmb.2012.08.022  1
2012 Yang Y, Ramelot TA, Cort JR, Garcia M, Yee A, Arrowsmith CH, Kennedy MA. Solution NMR structure of hypothetical protein CV_2116 encoded by a viral prophage element in Chromobacterium violaceum. International Journal of Molecular Sciences. 13: 7354-64. PMID 22837698 DOI: 10.3390/ijms13067354  1
2012 Popovic A, Wu B, Arrowsmith CH, Edwards AM, Davidson AR, Maxwell KL. Structural and biochemical characterization of phage λ FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity. The Journal of Biological Chemistry. 287: 32085-95. PMID 22801427 DOI: 10.1074/jbc.M112.378349  1
2012 Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, ... ... Arrowsmith CH, et al. An allosteric inhibitor of protein arginine methyltransferase 3. Structure (London, England : 1993). 20: 1425-35. PMID 22795084 DOI: 10.1016/j.str.2012.06.001  1
2012 Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D. Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Molecular Cell. 47: 383-95. PMID 22742833 DOI: 10.1016/j.molcel.2012.05.045  1
2012 Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, et al. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Science Signaling. 5: ra39. PMID 22649097 DOI: 10.1126/scisignal.2002979  1
2012 Brázda V, Coufal J, Liao JC, Arrowsmith CH. Preferential binding of IFI16 protein to cruciform structure and superhelical DNA. Biochemical and Biophysical Research Communications. 422: 716-20. PMID 22618232 DOI: 10.1016/j.bbrc.2012.05.065  1
2012 Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M. Epigenetic protein families: A new frontier for drug discovery Nature Reviews Drug Discovery. 11: 384-400. PMID 22498752 DOI: 10.1038/nrd3674  1
2012 Sheng Y, Hong JH, Doherty R, Srikumar T, Shloush J, Avvakumov GV, Walker JR, Xue S, Neculai D, Wan JW, Kim SK, Arrowsmith CH, Raught B, Dhe-Paganon S. A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Molecular & Cellular Proteomics : McP. 11: 329-41. PMID 22496338 DOI: 10.1074/mcp.O111.013706  1
2012 Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 149: 214-31. PMID 22464331 DOI: 10.1016/j.cell.2012.02.013  1
2012 Andresen C, Helander S, Lemak A, Farès C, Csizmok V, Carlsson J, Penn LZ, Forman-Kay JD, Arrowsmith CH, Lundström P, Sunnerhagen M. Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Research. 40: 6353-66. PMID 22457068 DOI: 10.1093/nar/gks263  1
2012 Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P, Gutmanas A, Güntert P, He Y, Herrmann T, Huang YJ, et al. Blind testing of routine, fully automated determination of protein structures from NMR data. Structure (London, England : 1993). 20: 227-36. PMID 22325772 DOI: 10.1016/j.str.2012.01.002  1
2012 Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG. Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. The Journal of Biological Chemistry. 287: 2317-27. PMID 22069321 DOI: 10.1074/jbc.M111.273730  1
2012 Allali-Hassani A, Wasney GA, Siarheyeva A, Hajian T, Arrowsmith CH, Vedadi M. Fluorescence-based methods for screening writers and readers of histone methyl marks. Journal of Biomolecular Screening. 17: 71-84. PMID 21972038 DOI: 10.1177/1087057111422256  1
2012 Cossar JD, Arrowsmith CH. Efficient strategies for production of egbraryotic proteins Comprehensive Biophysics. 1: 4-33. DOI: 10.1016/B978-0-12-374920-8.00104-1  1
2011 Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, ... ... Arrowsmith C, et al. Role of Pirh2 in mediating the regulation of p53 and c-Myc. Plos Genetics. 7: e1002360. PMID 22125490 DOI: 10.1371/journal.pgen.1002360  1
2011 Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH. Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A. Journal of Biomolecular Nmr. 51: 185-90. PMID 21947926 DOI: 10.1007/s10858-011-9552-y  1
2011 Brázda V, Laister RC, Jagelská EB, Arrowsmith C. Cruciform structures are a common DNA feature important for regulating biological processes. Bmc Molecular Biology. 12: 33. PMID 21816114 DOI: 10.1186/1471-2199-12-33  1
2011 Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 54: 6139-50. PMID 21780790 DOI: 10.1021/jm200903z  1
2011 Yoo J, Ko S, Kim H, Sampson H, Yun JH, Choe KM, Chang I, Arrowsmith CH, Krause HM, Cho HS, Lee W. Crystal structure of Fushi tarazu factor 1 ligand binding domain/Fushi tarazu peptide complex identifies new class of nuclear receptors. The Journal of Biological Chemistry. 286: 31225-31. PMID 21775434 DOI: 10.1074/jbc.M111.252916  1
2011 Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, ... ... Arrowsmith CH, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature Chemical Biology. 7: 566-74. PMID 21743462 DOI: 10.1038/nchembio.599  1
2011 Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chédin F, Arrowsmith CH, Dhe-Paganon S. Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. The Journal of Biological Chemistry. 286: 24300-11. PMID 21489993 DOI: 10.1074/jbc.M111.234104  1
2011 Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, et al. Small-molecule ligands of methyl-lysine binding proteins. Journal of Medicinal Chemistry. 54: 2504-11. PMID 21417280 DOI: 10.1021/jm200045v  1
2011 Liao JC, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, Xiao T, Tempel W, Zuo X, Wang YX, Chirgadze NY, Arrowsmith CH. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure (London, England : 1993). 19: 418-29. PMID 21397192 DOI: 10.1016/j.str.2010.12.015  1
2011 Ko S, Kim H, Yun J, Yee A, Arrowsmith CH, Cheong C, Lee W. Solution structure of MTH1821, a putative structure homologue to RNA polymerase α subunit from Methanobacterium thermoautotrophicum. Proteins. 79: 1347-51. PMID 21387412 DOI: 10.1002/prot.22956  1
2011 Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 117: 2451-9. PMID 21190999 DOI: 10.1182/blood-2010-11-321208  1
2011 Lemak A, Gutmanas A, Chitayat S, Karra M, Farès C, Sunnerhagen M, Arrowsmith CH. A novel strategy for NMR resonance assignment and protein structure determination. Journal of Biomolecular Nmr. 49: 27-38. PMID 21161328 DOI: 10.1007/s10858-010-9458-0  1
2011 Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH. Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. The Journal of Biological Chemistry. 286: 4796-808. PMID 21084285 DOI: 10.1074/jbc.M110.157669  1
2011 Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH. Recognition and specificity determinants of the human cbx chromodomains. The Journal of Biological Chemistry. 286: 521-9. PMID 21047797 DOI: 10.1074/jbc.M110.191411  1
2010 Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, et al. Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity. The Journal of Biological Chemistry. 285: 36070-80. PMID 20826778 DOI: 10.1074/jbc.M110.145219  1
2010 Sarkari F, La Delfa A, Arrowsmith CH, Frappier L, Sheng Y, Saridakis V. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. Journal of Molecular Biology. 402: 825-37. PMID 20713061 DOI: 10.1016/j.jmb.2010.08.017  1
2010 Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, ... Arrowsmith CH, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 53: 5844-57. PMID 20614940 DOI: 10.1021/jm100478y  1
2010 Wu B, Skarina T, Yee A, Jobin MC, Dileo R, Semesi A, Fares C, Lemak A, Coombes BK, Arrowsmith CH, Singer AU, Savchenko A. NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. Plos Pathogens. 6: e1000960. PMID 20585566 DOI: 10.1371/journal.ppat.1000960  1
2010 Vedadi M, Arrowsmith CH, Allali-Hassani A, Senisterra G, Wasney GA. Biophysical characterization of recombinant proteins: a key to higher structural genomics success. Journal of Structural Biology. 172: 107-19. PMID 20466062 DOI: 10.1016/j.jsb.2010.05.005  1
2010 Chitayat S, Arrowsmith CH. Four p(53)s in a pod. Nature Structural & Molecular Biology. 17: 390-1. PMID 20368720 DOI: 10.1038/nsmb0410-390  1
2010 Koulov AV, LaPointe P, Lu B, Razvi A, Coppinger J, Dong MQ, Matteson J, Laister R, Arrowsmith C, Yates JR, Balch WE. Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. Molecular Biology of the Cell. 21: 871-84. PMID 20089831 DOI: 10.1091/mbc.E09-12-1017  1
2009 Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH. Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins Biochemistry. 48: 10542-10548. PMID 19791798 DOI: 10.1021/bi901131u  1
2009 Brázda V, Jagelska EB, Liao JC, Arrowsmith CH. The central region of BRCA1 binds preferentially to supercoiled DNA. Journal of Biomolecular Structure & Dynamics. 27: 97-104. PMID 19492866 DOI: 10.1080/07391102.2009.10507299  1
2009 Montelione GT, Arrowsmith C, Girvin ME, Kennedy MA, Markley JL, Powers R, Prestegard JH, Szyperski T. Unique opportunities for NMR methods in structural genomics. Journal of Structural and Functional Genomics. 10: 101-6. PMID 19288278 DOI: 10.1007/s10969-009-9064-0  1
2009 Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Research. 37: 2204-10. PMID 19233876 DOI: 10.1093/nar/gkp086  1
2008 Nady N, Min J, Kareta MS, Chédin F, Arrowsmith CH. A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research. Trends in Biochemical Sciences. 33: 305-13. PMID 18538573 DOI: 10.1016/j.tibs.2008.04.014  1
2008 Lemak A, Steren CA, Arrowsmith CH, Llinás M. Sequence specific resonance assignment via Multicanonical Monte Carlo search using an ABACUS approach. Journal of Biomolecular Nmr. 41: 29-41. PMID 18458824 DOI: 10.1007/s10858-008-9238-2  1
2008 Ai X, Semesi A, Yee A, Arrowsmith CH, Choy WY, Li SS. The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin-like fold. Protein Science : a Publication of the Protein Society. 17: 154-8. PMID 18042676 DOI: 10.1110/ps.073167408  1
2007 Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. L3MBTL1 recognition of mono- and dimethylated histones. Nature Structural & Molecular Biology. 14: 1229-30. PMID 18026117 DOI: 10.1038/nsmb1340  1
2007 Wang X, Srisailam S, Yee AA, Lemak A, Arrowsmith C, Prestegard JH, Tian F. Domain-domain motions in proteins from time-modulated pseudocontact shifts. Journal of Biomolecular Nmr. 39: 53-61. PMID 17657568 DOI: 10.1007/s10858-007-9174-6  1
2007 Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY. Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold. Journal of Biomolecular Nmr. 38: 353-8. PMID 17610131 DOI: 10.1007/s10858-007-9172-8  1
2007 Monleón D, Yee A, Arrowsmith C, Celda B. NMR structure of hypothetical protein TA0938 from Thermoplasma acidophilum. Proteins. 67: 1185-8. PMID 17377985 DOI: 10.1002/prot.21143  1
2007 Ai X, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY. Backbone and side chain 1H, 13C, and 15N resonance assignments of AF2241 from Archaeoglobus fulgidus. Journal of Biomolecular Nmr. 38: 183. PMID 17206469 DOI: 10.1007/s10858-006-9114-x  1
2007 Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA. NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Proteins. 66: 266-71. PMID 17096419 DOI: 10.1002/prot.21199  1
2006 Jung J, Yeo IY, Hong E, Yee A, Arrowsmith CH, Lee W. Solution structure of TA0895, a MoaD homologue from Thermoplasma acidophilum. Proteins. 65: 1055-7. PMID 17019685 DOI: 10.1002/prot.21171  1
2006 Yee A, Gutmanas A, Arrowsmith CH. Solution NMR in structural genomics. Current Opinion in Structural Biology. 16: 611-7. PMID 16942869 DOI: 10.1016/j.sbi.2006.08.002  1
2006 Revington M, Semesi A, Yee A, Arrowsmith CH, Shaw GS. The solution structure of the protein ydhA from Escherichia coli. Journal of Biomolecular Nmr. 35: 295-300. PMID 16937244 DOI: 10.1007/s10858-006-9032-y  1
2006 Julien O, Gignac I, Hutton A, Yee A, Arrowsmith CH, Gagné SM. MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats. Journal of Biomolecular Nmr. 35: 149-54. PMID 16819590 DOI: 10.1007/s10858-006-0029-3  1
2006 Jeon BY, Jung J, Kim DW, Yee A, Arrowsmith CH, Lee W. Solution structure of TA1092, a ribosomal protein S24e from Thermoplasma acidophilum. Proteins. 64: 1095-7. PMID 16786596 DOI: 10.1002/prot.21045  1
2006 Srisailam S, Lukin JA, Yee A, Semesi A, Arrowsmith CH. Solution structure of acyl carrier protein from Nitrosomonas europaea. Proteins. 64: 800-3. PMID 16741959 DOI: 10.1002/prot.21016  1
2006 Srisailam S, Lukin JA, Lemak A, Yee A, Arrowsmith CH. Sequence specific resonance assignment of a hypothetical protein PA0128 from Pseudomonas aeruginosa. Journal of Biomolecular Nmr. 36: 27. PMID 16703420 DOI: 10.1007/s10858-006-0011-0  1
2006 Monleón D, Nunes S, Esteve V, Yee A, Arrowsmith C, Celda B. Resonance assignments for the hypothetical protein TA0938 from Thermoplasma acidophilum. Journal of Biomolecular Nmr. 36: 36. PMID 16703419 DOI: 10.1007/s10858-006-5968-1  1
2006 Kaustov L, Yi GS, Ayed A, Bochkareva E, Bochkarev A, Arrowsmith CH. p53 transcriptional activation domain: A molecular chameleon? Cell Cycle. 5: 489-494. PMID 16481746  1
2006 Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature Structural & Molecular Biology. 13: 285-91. PMID 16474402 DOI: 10.1038/nsmb1067  1
2006 Kim B, Jung J, Hong E, Yee A, Arrowsmith CH, Lee W. NMR structure of the conserved novel-fold protein TA0743 from Thermoplasma acidophilum. Proteins. 62: 819-21. PMID 16374782 DOI: 10.1002/prot.20832  1
2005 Bochkareva E, Kaustov L, Ayed A, Yi GS, Lu Y, Pineda-Lucena A, Liao JC, Okorokov AL, Milner J, Arrowsmith CH, Bochkarev A. Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A. Proceedings of the National Academy of Sciences of the United States of America. 102: 15412-7. PMID 16234232 DOI: 10.1073/pnas.0504614102  0.44
2005 Amegbey G, Stothard P, Kuznetsova E, Yee A, Arrowsmith CH, Wishart DS. Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum. Journal of Biomolecular Nmr. 33: 51-6. PMID 16222557 DOI: 10.1007/s10858-005-1275-5  1
2005 Luan T, Jaravine V, Yee A, Arrowsmith CH, Orekhov VY. Optimization of resolution and sensitivity of 4D NOESY using multi-dimensional decomposition. Journal of Biomolecular Nmr. 33: 1-14. PMID 16222553 DOI: 10.1007/s10858-005-1363-6  1
2005 Jung JW, Yee A, Wu B, Arrowsmith CH, Lee W. Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae. Journal of Biochemistry and Molecular Biology. 38: 550-4. PMID 16202234  1
2005 Grishaev A, Steren CA, Wu B, Pineda-Lucena A, Arrowsmith C, Llinás M. ABACUS, a direct method for protein NMR structure computation via assembly of fragments. Proteins. 61: 36-43. PMID 16080153 DOI: 10.1002/prot.20457  1
2005 Huang YJ, Moseley HN, Baran MC, Arrowsmith C, Powers R, Tejero R, Szyperski T, Montelione GT. An integrated platform for automated analysis of protein NMR structures. Methods in Enzymology. 394: 111-41. PMID 15808219 DOI: 10.1016/S0076-6879(05)94005-6  1
2005 Mark WY, Liao JC, Lu Y, Ayed A, Laister R, Szymczyna B, Chakrabartty A, Arrowsmith CH. Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions? Journal of Molecular Biology. 345: 275-87. PMID 15571721 DOI: 10.1016/j.jmb.2004.10.045  1
2004 Amegbey G, Chang Z, Stothard P, Yee A, Arrowsmith C, Wishart DS. Complete 1H, 13C and 15N NMR assignments of MTH0776 from Methanobacterium thermoautotrophicum. Journal of Biomolecular Nmr. 30: 459-60. PMID 15630567 DOI: 10.1007/s10858-004-4341-5  1
2004 Yakunin AF, Proudfoot M, Kuznetsova E, Savchenko A, Brown G, Arrowsmith CH, Edwards AM. The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2′,3′-cyclic phosphodiesterase, 2′-nucleotidase, and phosphatase activities Journal of Biological Chemistry. 279: 36819-36827. PMID 15210699 DOI: 10.1074/jbc.M405120200  1
2004 Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W. Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum. Protein Science : a Publication of the Protein Society. 13: 1148-54. PMID 15044740 DOI: 10.1110/ps.03472104  1
2004 Yakunin AF, Yee AA, Savchenko A, Edwards AM, Arrowsmith CH. Structural proteomics: a tool for genome annotation. Current Opinion in Chemical Biology. 8: 42-8. PMID 15036155 DOI: 10.1016/j.cbpa.2003.12.003  1
2004 Gutiérrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K. Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation. Protein Science : a Publication of the Protein Society. 13: 659-67. PMID 14978306 DOI: 10.1110/ps.03506604  1
2004 Bhattacharya S, Arunkumar AI, Sullivan SL, Botuyan MV, Arrowsmith CH, Chazin WJ. 1H, 13C and 15N assignments of single-stranded DNA binding domains from the 70 kDa subunit of human replication protein A. Journal of Biomolecular Nmr. 28: 195-6. PMID 14755166 DOI: 10.1023/B:JNMR.0000013818.02364.3a  1
2004 Monleón D, Yee A, Liu CS, Arrowsmith C, Celda B. Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum. Journal of Biomolecular Nmr. 28: 81-4. PMID 14739641 DOI: 10.1023/B:JNMR.0000012862.33577.74  1
2003 Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L. Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. The Journal of Biological Chemistry. 278: 47753-61. PMID 14506283 DOI: 10.1074/jbc.M307200200  1
2003 Xia Y, Yee A, Arrowsmith CH, Gao X. 1H(C) and 1H(N) total NOE correlations in a single 3D NMR experiment. 15N and 13C time-sharing in t1 and t2 dimensions for simultaneous data acquisition. Journal of Biomolecular Nmr. 27: 193-203. PMID 12975580 DOI: 10.1023/A:1025407905478  1
2003 Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA. Solution structure of the yeast ubiquitin-like modifier protein Hub1. Journal of Structural and Functional Genomics. 4: 25-30. PMID 12943364 DOI: 10.1023/A:1024674220425  1
2003 Maxwell KL, Bona D, Liu C, Arrowsmith CH, Edwards AM. Refolding out of guanidine hydrochloride is an effective approach for high-throughput structural studies of small proteins. Protein Science : a Publication of the Protein Society. 12: 2073-80. PMID 12931005 DOI: 10.1110/ps.0393503  1
2003 Daughdrill GW, Buchko GW, Botuyan MV, Arrowsmith C, Wold MS, Kennedy MA, Lowry DF. Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A. Nucleic Acids Research. 31: 4176-83. PMID 12853635 DOI: 10.1093/nar/gkg451  1
2003 Pineda-Lucena A, Liao JC, Cort JR, Yee A, Kennedy MA, Edwards AM, Arrowsmith CH. A novel member of the split betaalphabeta fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae. Protein Science : a Publication of the Protein Society. 12: 1136-40. PMID 12717036 DOI: 10.1110/ps.0240903  0.32
2003 Yee A, Pardee K, Christendat D, Savchenko A, Edwards AM, Arrowsmith CH. Structural proteomics: toward high-throughput structural biology as a tool in functional genomics. Accounts of Chemical Research. 36: 183-9. PMID 12641475 DOI: 10.1021/ar010126g  1
2003 Gerstein M, Edwards A, Arrowsmith CH, Montelione GT. Structural genomics: Current progress [3] Science. 299: 1663. PMID 12637721  1
2003 Szymczyna BR, Bowman J, McCracken S, Pineda-Lucena A, Lu Y, Cox B, Lambermon M, Graveley BR, Arrowsmith CH, Blencowe BJ. Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. Genes & Development. 17: 461-75. PMID 12600940 DOI: 10.1101/gad.1060403  1
2003 Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L. Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. The Journal of Biological Chemistry. 278: 8804-8. PMID 12496312 DOI: 10.1074/jbc.M211892200  1
2002 Kennedy MA, Montelione GT, Arrowsmith CH, Markley JL. Role for NMR in structural genomics. Journal of Structural and Functional Genomics. 2: 155-69. PMID 12836706 DOI: 10.1023/A:1021261026670  1
2002 Xia Y, Arrowsmith CH, Szyperski T. Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment. Journal of Biomolecular Nmr. 24: 41-50. PMID 12449417 DOI: 10.1023/A:1020605618150  1
2002 Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA. NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins. Proteins. 49: 289-93. PMID 12211008 DOI: 10.1002/prot.10214  1
2002 Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L. Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase. Proteins. 49: 285-8. PMID 12211007 DOI: 10.1002/prot.10209  1
2002 Kim Y, Skarina T, Beasley S, Laskowski R, Arrowsmith C, Joachimiak A, Edwards A, Savchenko A. Crystal structure of Escherichia coli EC1530, a glyoxylate induced protein YgbM. Proteins. 48: 427-30. PMID 12112708 DOI: 10.1002/prot.10160  1
2002 Maxwell KL, Yee AA, Arrowsmith CH, Gold M, Davidson AR. The solution structure of the bacteriophage lambda head-tail joining protein, gpFII. Journal of Molecular Biology. 318: 1395-404. PMID 12083526 DOI: 10.1016/S0022-2836(02)00276-0  1
2002 Gutiérrez P, Coillet-Matillon S, Arrowsmith C, Gehring K. Zinc is required for structural stability of the C-terminus of archaeal translation initiation factor aIF2β Febs Letters. 517: 155-158. PMID 12062427 DOI: 10.1016/S0014-5793(02)02610-8  1
2002 Saridakis V, Christendat D, Thygesen A, Arrowsmith CH, Edwards AM, Pai EF. Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold. Proteins. 48: 141-3. PMID 12012346 DOI: 10.1002/prot.10147  1
2002 Szymczyna BR, Pineda-Lucena A, Mills JL, Szyperski T, Arrowsmith CH. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. Journal of Biomolecular Nmr. 22: 299-300. PMID 11991360 DOI: 10.1023/A:1014904502424  1
2002 Bhattacharyya S, Habibi-Nazhad B, Amegbey G, Slupsky CM, Yee A, Arrowsmith C, Wishart DS. Identification of a novel archaebacterial thioredoxin: Determination of function through structure Biochemistry. 41: 4760-4770. PMID 11939770 DOI: 10.1021/bi0115176  1
2002 Zhang RG, Kim Y, Skarina T, Beasley S, Laskowski R, Arrowsmith C, Edwards A, Joachimiak A, Savchenko A. Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family. The Journal of Biological Chemistry. 277: 19183-90. PMID 11877432 DOI: 10.1074/jbc.M112171200  1
2002 Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, Joachimiak A, Pegg AE, Savchenko A. The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nature Structural Biology. 9: 27-31. PMID 11731804 DOI: 10.1038/nsb737  1
2001 Das K, Xiao R, Wahlberg E, Hsu F, Arrowsmith CH, Montelione GT, Arnold E. X-ray crystal structure of MTH938 from methanobacterium thermoautotrophicum at 2.2 Å resolution reveals a novel tertiary protein fold Proteins: Structure, Function and Genetics. 45: 486-488. PMID 11746696 DOI: 10.1002/prot.1162  1
2001 Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP. NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum [1] Journal of Biomolecular Nmr. 21: 63-66. PMID 11693569 DOI: 10.1023/A:1011928105928  1
2001 Ayed A, Mulder FAA, Yi GS, Lu Y, Kay LE, Arrowsmith CH. Latent and active p53 are identical in conformation Nature Structural Biology. 8: 756-760. PMID 11524676 DOI: 10.1038/nsb0901-756  1
2001 Daughdrill GW, Ackerman J, Isern NG, Botuyan MV, Arrowsmith C, Wold MS, Lowry DF. The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding. Nucleic Acids Research. 29: 3270-6. PMID 11470885  1
2001 Elston DA, Moss R, Boulinier T, Arrowsmith C, Lambin X. Analysis of aggregation, a worked example: Numbers of ticks on red grouse chicks Parasitology. 122: 563-569. PMID 11393830 DOI: 10.1017/S0031182001007740  1
2001 Maxwell KL, Yee AA, Booth V, Arrowsmith CH, Gold M, Davidson AR. The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold. Journal of Molecular Biology. 308: 9-14. PMID 11302702 DOI: 10.1006/jmbi.2001.4582  1
2001 Pineda-Lucena A, Arrowsmith CH. 1H, 13C and 15N resonance assignments and secondary structure of the c-Myc binding domain (MBD) and the SH3 domain of the tumor suppressor Bin1 [3] Journal of Biomolecular Nmr. 19: 191-192. PMID 11256816 DOI: 10.1023/A:1008387817677  1
2001 Davison TS, Nie X, Ma W, Lin Y, Kay C, Benchimol S, Arrowsmith CH. Structure and functionality of a designed p53 dimer. Journal of Molecular Biology. 307: 605-17. PMID 11254385 DOI: 10.1006/jmbi.2001.4450  1
2000 Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA. NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum. Journal of Structural and Functional Genomics. 1: 15-25. PMID 12836677  1
2000 Mulder FAA, Ayed A, Yang D, Arrowsmith CH, Kay LE. Assignment of 1H(N), 15N, 13C(α), 13CO and 13C(β) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy Journal of Biomolecular Nmr. 18: 173-176. PMID 11101222 DOI: 10.1023/A:1008317825976  1
2000 Christendat D, Yee A, Dharamsi A, Kluger Y, Gerstein M, Arrowsmith CH, Edwards AM. Structural proteomics: Prospects for high throughput sample preparation Progress in Biophysics and Molecular Biology. 73: 339-345. PMID 11063779 DOI: 10.1016/S0079-6107(00)00010-9  1
2000 Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA. Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum Journal of Molecular Biology. 302: 189-203. PMID 10964569 DOI: 10.1006/jmbi.2000.4052  1
2000 Noolandi J, Davison TS, Volkel AR, Nie X, Kay C, Arrowsmith CH. A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53. Proceedings of the National Academy of Sciences of the United States of America. 97: 9955-60. PMID 10944184 DOI: 10.1073/pnas.160075697  1
2000 Szymczyna BR, Arrowsmith CH. DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition. The Journal of Biological Chemistry. 275: 28363-70. PMID 10867009 DOI: 10.1074/jbc.M004294200  1
2000 Mackereth CD, Arrowsmith CH, Edwards AM, McIntosh LP. Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum. Proceedings of the National Academy of Sciences of the United States of America. 97: 6316-21. PMID 10841539 DOI: 10.1073/pnas.97.12.6316  1
2000 Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH. Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum Proceedings of the National Academy of Sciences of the United States of America. 97: 6311-6315. PMID 10841538 DOI: 10.1073/pnas.97.12.6311  1
2000 Christendat D, Saridakis V, Dharamsi A, Bochkarev A, Pai EF, Arrowsmith CH, Edwards AM. Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP Journal of Biological Chemistry. 275: 24608-24612. PMID 10827167 DOI: 10.1074/jbc.C000238200  1
2000 Booth V, Koth CM, Edwards AM, Arrowsmith CH. Structure of a conserved domain common to the transcription factors TFIIS, Elongin A, and CRSP70 Journal of Biological Chemistry. 275: 31266-31268. PMID 10811649  1
2000 Li PX, Wong J, Ayed A, Ngo D, Brade AM, Arrowsmith C, Austin RC, Klamut HJ. Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. The Journal of Biological Chemistry. 275: 20127-35. PMID 10777512 DOI: 10.1074/jbc.M909580199  1
2000 Edwards AM, Arrowsmith CH, Des Pallieres BD. Proteomics: New tools for a new era - Bridging the gap between genomics and drug discovery Modern Drug Discovery. 3: 35-44.  1
1999 Arrowsmith CH. Structure and function in the p53 family Cell Death and Differentiation. 6: 1169-1173. PMID 10637432  1
1999 Chi SW, Ayed A, Arrowsmith CH. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. The Embo Journal. 18: 4438-45. PMID 10449409 DOI: 10.1093/emboj/18.16.4438  1
1999 Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. The Journal of Biological Chemistry. 274: 18709-14. PMID 10373484 DOI: 10.1074/jbc.274.26.18709  1
1998 Bagby S, Arrowsmith CH, Ikura M. New perceptions of transcription factor properties from NMR Biochemistry and Cell Biology. 76: 368-378. PMID 9923706  1
1998 Davison TS, Yin P, Nie E, Kay C, Arrowsmith CH. Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome. Oncogene. 17: 651-6. PMID 9704931 DOI: 10.1038/sj.onc.1202062  1
1998 Shan X, Gardner KH, Muhandiram DR, Kay LE, Arrowsmith CH. Subunit-specific backbone NMR assignments of a 64 kDa trp repressor/DNA complex: a role for N-terminal residues in tandem binding. Journal of Biomolecular Nmr. 11: 307-18. PMID 9691278  1
1998 Petra G, Yee AA, Arrowsmith CH, Macgregor RB. Quantitative hydroxyl radical footprinting reveals cooperative interactions between DNA-binding subdomains of PU.1 and IRF4 Biochemistry. 37: 9802-9811. PMID 9657694 DOI: 10.1021/bi9731448  1
1998 Yee AA, Yin P, Siderovski DP, Mak TW, Litchfield DW, Arrowsmith CH. Cooperative interaction between the DNA-binding domains of PU.1 and IRF4 Journal of Molecular Biology. 279: 1075-1083. PMID 9642085 DOI: 10.1006/jmbi.1998.1838  1
1998 Gross P, Arrowsmith CH, Macgregor RB. Hydroxyl radical footprinting of DNA complexes of the ets domain of PU.1 and its comparison to the crystal structure Biochemistry. 37: 5129-5135. PMID 9548743 DOI: 10.1021/bi972591k  1
1997 Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. The Embo Journal. 16: 6018-33. PMID 9312059 DOI: 10.1093/emboj/16.19.6018  1
1997 Moseley HN, Lee W, Arrowsmith CH, Krishna NR. Quantitative determination of conformational, dynamic, and kinetic parameters of a ligand-protein/DNA complex from a complete relaxation and conformational exchange matrix analysis of intermolecular transferred NOESY. Biochemistry. 36: 5293-9. PMID 9154911 DOI: 10.1021/bi970242k  1
1996 Morin PE, Awrey DE, Edwards AM, Arrowsmith CH. Elongation factor TFIIS contains three structural domains: Solution structure of domain II Proceedings of the National Academy of Sciences of the United States of America. 93: 10604-10608. PMID 8855225 DOI: 10.1073/pnas.93.20.10604  1
1996 Arrowsmith CH, Morin P. New insights into p53 function from structural studies Oncogene. 12: 1379-1385. PMID 8622853  1
1996 Shan X, Gardner KH, Muhandiram DR, Rao NS, Arrowsmith CH, Kay LE. Assignment of 15N, 13C(α), 13C(β), and HN resonances in an 15N,13C,2H labeled 64 kDa trp repressor-operator complex using triple-resonance NMR spectroscopy and 2H-decoupling Journal of the American Chemical Society. 118: 6570-6579. DOI: 10.1021/ja960627a  1
1995 Yin Y, Zhang F, Ling V, Arrowsmith CH. Structural analysis and comparison of the C-terminal transport signal domains of hemolysin A and leukotoxin A. Febs Letters. 366: 1-5. PMID 7789505 DOI: 10.1016/0014-5793(95)00454-H  1
1995 Johnson CR, Morin PE, Arrowsmith CH, Freire E. Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor Biochemistry. 34: 5309-5316. PMID 7727392  1
1995 Arrowsmith CH, Lee W, Revington M, Yamazaki T, Kay LE. Toward the solution structure of large (>30 kDa) proteins and macromolecular complexes Techniques in Protein Chemistry. 6: 503-510. DOI: 10.1016/S1080-8914(06)80061-X  1
1994 Zhang H, Zhao D, Revington M, Lee W, Jia X, Arrowsmith C, Jardetzky O. The solution structures of the trp repressor-operator DNA complex. Journal of Molecular Biology. 238: 592-614. PMID 8176748 DOI: 10.1006/jmbi.1994.1317  1
1994 Lee W, Revington MJ, Arrowsmith C, Kay LE. A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes Febs Letters. 350: 87-90. PMID 8062930 DOI: 10.1016/0014-5793(94)00740-3  1
1994 Lee W, Harvey TS, Yin Y, Yau P, Litchfield D, Arrowsmith CH. Solution structure of the tetrameric minimum transforming domain of p53 Nature Structural Biology. 1: 877-890. PMID 7773777 DOI: 10.1038/nsb1294-877  1
1994 Arrowsmith CH, Guo HX, Kresge AJ. Hydrogen isotope fractionation factors for benzylamine and benzylammonium ion. Comparison of fractionation factors for neutral and positively-charged nitrogen-hydrogen bonds Journal of the American Chemical Society. 116: 8890-8894.  1
1994 Yamazaki T, Lee W, Arrowsmith CH, Muhandiram DR, Kay LE. A suite of triple resonance NMR experiments for the backbone assignment of 15N, 13C, 2H labeled proteins with high sensitivity Journal of the American Chemical Society. 116: 11655-11666.  1
1993 Zhao D, Arrowsmith CH, Jia X, Jardetzky O. Refined solution structures of the Escherichia coli trp holo- and aporepressor. Journal of Molecular Biology. 229: 735-46. PMID 8433368 DOI: 10.1006/jmbi.1993.1076  1
1992 Pachter R, Arrowsmith CH, Jardetzky O. The effect of selective deuteration on magnetization transfer in larger proteins. Journal of Biomolecular Nmr. 2: 183-94. PMID 1422151 DOI: 10.1007/BF01875529  1
1991 Arrowsmith C, Pachter R, Altman R, Jardetzky O. The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution. European Journal of Biochemistry / Febs. 202: 53-66. PMID 1935980  1
1991 Czaplicki J, Arrowsmith C, Jardetzky O. Segmental differences in the stability of the trp-repressor peptide backbone. Journal of Biomolecular Nmr. 1: 349-61. PMID 1841704 DOI: 10.1007/BF02192859  1
1991 Arrowsmith CH, Kresge AJ, Tang YC. The base-catalyzed decomposition of nitramide: Mechanism of the second reaction pathway Journal of the American Chemical Society. 113: 179-182.  1
1991 Arrowsmith CH, Czaplicki J, Iyer SB, Jardetzky O. Unusual dynamic features of the trp repressor from Escherichia coli Journal of the American Chemical Society. 113: 4020-4022.  1
1990 Arrowsmith CH, Pachter R, Altman RB, Iyer SB, Jardetzky O. Sequence-specific 1H NMR assignments and secondary structure in solution of Escherichia coli trp repressor. Biochemistry. 29: 6332-41. PMID 2207078  1
1990 Arrowsmith CH, Treat‐Clemons L, Szilágyi L, Pachter R, Jardetzky O. The use of selective deuteration for the sequence specific 1H NMR assignment of larger proteins Makromolekulare Chemie. Macromolecular Symposia. 34: 33-46. DOI: 10.1002/masy.19900340104  1
1989 Arrowsmith CH, Carey J, Treat-Clemons L, Jardetzky O. NMR assignments for the amino-terminal residues of trp repressor and their role in DNA binding. Biochemistry. 28: 3875-9. PMID 2665811  1
1987 Aroella T, Arrowsmith CH, Hojatti M, Kresge AJ, Powell MF, Tang YS, Wang WH. The ionization of terminal acetylenes: Pseudoacid behavior Journal of the American Chemical Society. 109: 7198-7199.  1
1986 Arrowsmith CH, Kresge AJ. A correlation between β-hydrogen isotope effects on carbon-13 NMR chemical shifts in unsaturated systems and the strength of hyperconjugative interactions Journal of the American Chemical Society. 108: 7918-7920.  1
1986 Arrowsmith CH, Baitzer L, Jerry Kresge A, Powell MF, Tang YS. Tritium isotope effects on carbon-13 NMR chemical shifts Journal of the American Chemical Society. 108: 1356-1357.  1
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