Cheryl Arrowsmith - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
General Biophysics, Biochemistry

498 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Guegueniat J, Halabelian L, Zeng H, Dong A, Li Y, Wu H, Arrowsmith CH, Kothe U. The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface. Nucleic Acids Research. PMID 34718722 DOI: 10.1093/nar/gkab934  1
2021 Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sánchez-Osuna M, Coulombe-Huntington J, Huard C, Mohammed M, Lima-Fernandes E, Thériault B, Halabelian L, Chan M, Joshi D, Drecun L, ... ... Arrowsmith C, et al. Chemical genetics screen identifies COPB2 tool compounds that alters ER stress response and induces RTK dysregulation in lung cancer cells. Journal of Molecular Biology. 167294. PMID 34662547 DOI: 10.1016/j.jmb.2021.167294  1
2021 Mann MK, Zepeda-Velázquez CA, González-Álvarez H, Dong A, Kiyota T, Aman AM, Loppnau P, Li Y, Wilson B, Arrowsmith CH, Al-Awar R, Harding RJ, Schapira M. Structure-Activity Relationship of USP5 Inhibitors. Journal of Medicinal Chemistry. PMID 34648286 DOI: 10.1021/acs.jmedchem.1c00889  1
2021 Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, Arrowsmith CH, Raught B, Penn LZ. MYC protein interactors in gene transcription and cancer. Nature Reviews. Cancer. PMID 34188192 DOI: 10.1038/s41568-021-00367-9  1
2021 Gradl S, Steuber H, Weiske J, Szewczyk MM, Schmees N, Siegel S, Stoeckigt D, Christ CD, Li F, Organ S, Abbey M, Kennedy S, Chau I, Trush V, Barsyte-Lovejoy D, ... ... Arrowsmith C, et al. Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. Slas Discovery : Advancing Life Sciences R & D. 24725552211019409. PMID 34154424 DOI: 10.1177/24725552211019409  1
2021 Resetca D, MacDonald AS, Kenney TMG, Wei Y, Arrowsmith CH, Raught B, Penn LZ. Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies. Methods in Molecular Biology (Clifton, N.J.). 2318: 45-67. PMID 34019286 DOI: 10.1007/978-1-0716-1476-1_4  1
2021 Dölle A, Adhikari B, Krämer A, Weckesser J, Berner N, Berger LM, Diebold M, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Gebel J, Löhr F, Dötsch V, Eilers M, Heinzlmeir S, et al. Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry. PMID 33980013 DOI: 10.1021/acs.jmedchem.1c00146  1
2021 Wu Q, Schapira M, Arrowsmith CH, Barsyte-Lovejoy D. Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nature Reviews. Drug Discovery. PMID 33742187 DOI: 10.1038/s41573-021-00159-8  1
2021 Shen Y, Li F, Szewczyk MM, Halabelian L, Chau I, Eram MS, Dela Seña C, Park KS, Meng F, Chen H, Zeng H, McLeod D, Zepeda-Velázquez CA, Campbell RM, Mader MM, ... ... Arrowsmith CH, et al. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry. PMID 33591753 DOI: 10.1021/acs.jmedchem.0c02160  1
2021 Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, ... ... Arrowsmith CH, et al. PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature Communications. 12: 979. PMID 33579912 DOI: 10.1038/s41467-021-21204-5  1
2021 Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, ... ... Arrowsmith CH, et al. RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. The Journal of Clinical Investigation. 131. PMID 33529165 DOI: 10.1172/JCI140105  1
2021 Ferreira de Freitas R, Liu Y, Szewczyk MM, Mehta N, Li F, McLeod D, Zepeda-Velázquez C, Dilworth D, Hanley RP, Gibson E, Brown PJ, Al-Awar R, James LI, Arrowsmith CH, Barsyte-Lovejoy D, et al. Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of Medicinal Chemistry. PMID 33522809 DOI: 10.1021/acs.jmedchem.0c01768  1
2021 Santhakumar V, Sutherland M, Li A, Kaghad A, Panagopoulos D, Li F, Szewczyk M, Smil D, Scholten C, Bouché L, Stellfeld T, Arrowsmith CH, Barsyte D, Vedadi M, Hartung IV, et al. Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics. Chemmedchem. PMID 33513288 DOI: 10.1002/cmdc.202100018  1
2020 Ostrop J, Zwiggelaar RT, Terndrup Pedersen M, Gerbe F, Bösl K, Lindholm HT, Díez-Sánchez A, Parmar N, Radetzki S, von Kries JP, Jay P, Jensen KB, Arrowsmith C, Oudhoff MJ. A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation. Frontiers in Cell and Developmental Biology. 8: 618552. PMID 33575256 DOI: 10.3389/fcell.2020.618552  0.01
2020 Zhu Z, Han Z, Halabelian L, Yang X, Ding J, Zhang N, Ngo L, Song J, Zeng H, He M, Zhao Y, Arrowsmith CH, Luo M, Bartlett MG, Zheng YG. Identification of lysine isobutyrylation as a new histone modification mark. Nucleic Acids Research. PMID 33313896 DOI: 10.1093/nar/gkaa1176  1
2020 Conway SJ, Arimondo P, Arrowsmith C, Jin J, Luo C, Meanwell N, Young W, Georg G, Wang S. Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers. Journal of Medicinal Chemistry. PMID 33090784 DOI: 10.1021/acs.jmedchem.0c01748  0.04
2020 Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, ... ... Arrowsmith CH, et al. Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife. 9. PMID 33054974 DOI: 10.7554/eLife.63994  1
2020 Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, ... Arrowsmith C, et al. LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium. Science Advances. 6. PMID 32917713 DOI: 10.1126/Sciadv.Abc0367  1
2020 Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, Haight J, Tonekaboni SAM, Fortier AM, Kuasne H, McKee TD, Mahmoud H, Kushida M, Cameron S, Dogan-Artun N, ... ... Arrowsmith CH, et al. GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer. Nature Communications. 11: 4205. PMID 32826891 DOI: 10.1038/S41467-020-18020-8  1
2020 Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, Haight J, Tonekaboni SAM, Fortier AM, Kuasne H, McKee TD, Mahmoud H, Kushida M, Cameron S, Dogan-Artun N, ... ... Arrowsmith CH, et al. GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer. Nature Communications. 11: 4205. PMID 32826891 DOI: 10.1038/S41467-020-18020-8  1
2020 Tauber M, Kreuz S, Lemak A, Mandal P, Yerkesh Z, Veluchamy A, Al-Gashgari B, Aljahani A, Cortés-Medina LV, Azhibek D, Fan L, Ong MS, Duan S, Houliston S, Arrowsmith CH, et al. Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1. Nucleic Acids Research. PMID 32609811 DOI: 10.1093/nar/gkaa520  1
2020 Deblois G, Madani Tonekaboni SA, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, ... ... Arrowsmith CH, et al. Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer. Cancer Discovery. PMID 32546577 DOI: 10.1158/2159-8290.Cd-19-1493  1
2020 Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, ... ... Arrowsmith CH, et al. Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature Communications. 11: 2683. PMID 32457299 DOI: 10.1038/S41467-020-16613-X  1
2020 Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, ... ... Arrowsmith CH, et al. Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell. PMID 32445698 DOI: 10.1016/J.Cell.2020.04.047  1
2020 Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, ... ... Arrowsmith CH, et al. Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nature Communications. 11: 2396. PMID 32409666 DOI: 10.1038/S41467-020-16271-Z  1
2020 Shen Y, Li F, Szewczyk MM, Halabelian L, Park KS, Chau I, Dong A, Zeng H, Chen H, Meng F, Barsyte-Lovejoy D, Arrowsmith CH, Brown P, Liu J, Vedadi M, et al. Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. Journal of Medicinal Chemistry. PMID 32367723 DOI: 10.1021/Acs.Jmedchem.0C00406  1
2020 Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L. Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment. Elife. 9. PMID 32297856 DOI: 10.7554/Elife.47333  1
2020 Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind L. HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Molecular Cell. 77: 1154. PMID 32142687 DOI: 10.1016/j.molcel.2020.02.008  1
2019 Allali-Hassani A, Szewczyk MM, Ivanochko D, Organ SL, Bok J, Ho JSY, Gay FPH, Li F, Blazer L, Eram MS, Halabelian L, Dilworth D, Luciani GM, Lima-Fernandes E, Wu Q, ... ... Arrowsmith CH, et al. Discovery of a chemical probe for PRDM9. Nature Communications. 10: 5759. PMID 31848333 DOI: 10.1038/s41467-019-13652-x  1
2019 Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind L. HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Molecular Cell. PMID 31806351 DOI: 10.1016/J.Molcel.2019.10.031  1
2019 Mann MK, Franzoni I, de Freitas RF, Tempel W, Houliston S, Smith L, Vedadi M, Arrowsmith CH, Harding RJ, Schapira M. Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. Journal of Medicinal Chemistry. PMID 31663737 DOI: 10.1021/acs.jmedchem.9b00988  1
2019 Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, ... ... Arrowsmith CH, et al. A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife. 8. PMID 31657716 DOI: 10.7554/Elife.47110  1
2019 Arrowsmith CH, Schapira M. Targeting non-bromodomain chromatin readers. Nature Structural & Molecular Biology. 26: 863-869. PMID 31582844 DOI: 10.1038/s41594-019-0290-2  1
2019 Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford JE, Nibhani R, Philpott M, Malzahn J, Wells G, Farham R, Cribbs A, Halidi N, Li F, Chau I, Greschik H, ... ... Arrowsmith CH, et al. A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. Journal of Medicinal Chemistry. PMID 31550156 DOI: 10.1021/Acs.Jmedchem.9B00562  1
2019 Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, ... ... Arrowsmith C, et al. Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Cancer Cell. 36: 338-339. PMID 31526762 DOI: 10.1016/j.ccell.2019.08.012  1
2019 Taylor AP, Szewczyk MM, Kennedy S, Trush VV, Wu H, Zeng H, Dong A, de Freitas RF, Tatlock JH, Kumpf RA, Wythes M, Casimiro-Garcia A, Denny RA, Parikh MD, Li F, ... ... Arrowsmith CH, et al. Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase. Journal of Medicinal Chemistry. PMID 31415173 DOI: 10.1021/acs.jmedchem.9b00112  1
2019 Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, ... ... Arrowsmith CH, et al. Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer Cell. 36: 194-209.e9. PMID 31408619 DOI: 10.1016/J.Ccell.2019.07.003  1
2019 Kaustov L, Lemak A, Wu H, Faini M, Fan L, Fang X, Zeng H, Duan S, Allali-Hassani A, Li F, Wei Y, Vedadi M, Aebersold R, Wang Y, Houliston S, ... Arrowsmith CH, et al. The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions. Nucleic Acids Research. PMID 31400120 DOI: 10.1093/Nar/Gkz697  1
2019 Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless VB, Liew SK, Houliston SR, De Freitas RF, Smil D, Sena CCD, Kennedy S, Diaz DB, Wu H, Dombrovski L, ... ... Arrowsmith CH, et al. Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Bioorganic & Medicinal Chemistry. PMID 31327677 DOI: 10.1016/J.Bmc.2019.07.020  1
2019 Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, ... ... Arrowsmith CH, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature Chemical Biology. PMID 31285596 DOI: 10.1038/S41589-019-0310-X  1
2019 Carter AJ, Kraemer O, Zwick M, Mueller-Fahrnow A, Arrowsmith CH, Edwards AM. Target 2035: probing the human proteome. Drug Discovery Today. PMID 31278990 DOI: 10.1016/j.drudis.2019.06.020  1
2019 Xiong Y, Greschik H, Johansson C, Seifert L, Bacher J, Park KS, Babault N, Martini ML, Fagan V, Li F, Chau I, Christott T, Dilworth D, Barsyte-Lovejoy D, Vedadi M, ... Arrowsmith CH, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). Journal of Medicinal Chemistry. PMID 31260300 DOI: 10.1021/Acs.Jmedchem.9B00522  1
2019 Halabelian L, Ravichandran M, Li Y, Zeng H, Rao A, Aravind L, Arrowsmith CH. Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition. Nature Structural & Molecular Biology. PMID 31235913 DOI: 10.1038/s41594-019-0246-6  1
2019 Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, ... ... Arrowsmith C, et al. Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Cancer Cell. 35: 782-797.e8. PMID 31085178 DOI: 10.1016/J.Ccell.2019.04.004  1
2019 Suh JL, Barnash KD, Abramyan TM, Li F, The J, Engelberg IA, Vedadi M, Brown PJ, Kireev DB, Arrowsmith CH, James LI, Frye SV. Discovery of selective activators of PRC2 mutant EED-I363M. Scientific Reports. 9: 6524. PMID 31024026 DOI: 10.1038/S41598-019-43005-Z  1
2019 Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, ... Arrowsmith CH, et al. A chemical toolbox for the study of bromodomains and epigenetic signaling. Nature Communications. 10: 1915. PMID 31015424 DOI: 10.1038/S41467-019-09672-2  1
2019 Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, ... ... Arrowsmith CH, et al. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nature Communications. 10: 1436. PMID 30926792 DOI: 10.1038/S41467-019-09309-4  1
2019 Wang Z, Kang L, Zhang H, Huang Y, Fang L, Li M, Brown PJ, Arrowsmith CH, Li J, Wong J. AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation. Oncogene. PMID 30894683 DOI: 10.1038/s41388-019-0790-x  1
2019 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, ... ... Arrowsmith CH, et al. Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 30842648 DOI: 10.1038/s41589-019-0242-5  1
2019 Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HÜ, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, ... ... Arrowsmith CH, et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nature Communications. 10: 19. PMID 30604761 DOI: 10.1038/S41467-018-07905-4  1
2018 Dilworth D, Arrowsmith CH. Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling. Structure (London, England : 1993). 26: 1567-1570. PMID 30517884 DOI: 10.1016/j.str.2018.11.010  0.01
2018 Ivanochko D, Halabelian L, Henderson E, Savitsky P, Jain H, Marcon E, Duan S, Hutchinson A, Seitova A, Barsyte-Lovejoy D, Filippakopoulos P, Greenblatt J, Lima-Fernandes E, Arrowsmith CH. Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Research. PMID 30462309 DOI: 10.1093/Nar/Gky1192  1
2018 Luciani GM, Xie L, Dilworth D, Tierens A, Moskovitz Y, Murison A, Szewczyk MM, Mitchell A, Lupien M, Shlush L, Dick JE, Arrowsmith CH, Barsyte-Lovejoy D, Minden MD. Characterization of inv(3) cell line OCI-AML-20 with stroma dependent CD34 expression. Experimental Hematology. PMID 30352278 DOI: 10.1016/J.Exphem.2018.10.006  1
2018 Kagoya Y, Saijo H, Matsunaga Y, Guo T, Saso K, Anczurowski M, Wang CH, Sugata K, Murata K, Butler MO, Arrowsmith CH, Hirano N. Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells. Journal of Autoimmunity. PMID 30318155 DOI: 10.1016/j.jaut.2018.09.011  1
2018 Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, et al. MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. Cancer Cell. 34: 579-595.e8. PMID 30300580 DOI: 10.1016/J.Ccell.2018.09.001  1
2018 Valleau D, Little DJ, Borek D, Skarina T, Quaile AT, Di Leo R, Houliston S, Lemak A, Arrowsmith CH, Coombes BK, Savchenko A. Functional diversification of the NleG effector family in enterohemorrhagic . Proceedings of the National Academy of Sciences of the United States of America. PMID 30217892 DOI: 10.1073/Pnas.1718350115  1
2018 Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ. The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nature Communications. 9: 3411. PMID 30143613 DOI: 10.1038/s41467-018-05646-y  1
2018 Bonday ZQ, Cortez GS, Grogan MJ, Antonysamy S, Weichert K, Bocchinfuso WP, Li F, Kennedy S, Li B, Mader MM, Arrowsmith CH, Brown PJ, Eram MS, Szewczyk MM, Barsyte-Lovejoy D, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. Acs Medicinal Chemistry Letters. 9: 612-617. PMID 30034588 DOI: 10.1021/acsmedchemlett.8b00014  1
2018 Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T. Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9. The Journal of Biological Chemistry. PMID 29959229 DOI: 10.1074/Jbc.Ra118.002890  0.01
2018 Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, ... ... Arrowsmith C, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. The Journal of Cell Biology. PMID 29921600 DOI: 10.1083/Jcb.201804042  1
2018 Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang CH, Butler MO, Arrowsmith CH, Hirano N. DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models. Nature Communications. 9: 1915. PMID 29765028 DOI: 10.1038/s41467-018-04262-0  1
2018 Ferreira de Freitas R, Harding RJ, Franzoni I, Ravichandran M, Mann MK, Ouyang H, Lautens M, Santhakumar V, Arrowsmith CH, Schapira M. Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. Journal of Medicinal Chemistry. PMID 29741882 DOI: 10.1021/Acs.Jmedchem.8B00258  1
2018 Nakayama K, Szewczyk MM, Dela Sena C, Wu H, Dong A, Zeng H, Li F, de Freitas RF, Eram MS, Schapira M, Baba Y, Kunitomo M, Cary DR, Tawada M, Ohashi A, ... ... Arrowsmith CH, et al. TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget. 9: 18480-18493. PMID 29719619 DOI: 10.18632/oncotarget.24883  1
2018 Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, et al. Donated chemical probes for open science. Elife. 7. PMID 29676732 DOI: 10.7554/Elife.34311  1
2018 Valleau D, Quaile AT, Cui H, Xu X, Evdokimova E, Chang C, Cuff ME, Urbanus ML, Houliston S, Arrowsmith CH, Ensminger AW, Savchenko A. Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila. Cell Reports. 23: 568-583. PMID 29642013 DOI: 10.1016/J.Celrep.2018.03.060  1
2018 Senisterra G, Zhu HY, Luo X, Zhang H, Xun G, Lu C, Xiao W, Hajian T, Loppnau P, Chau I, Li F, Allali-Hassani A, Atadja P, Oyang C, Li E, ... ... Arrowsmith CH, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. Slas Discovery : Advancing Life Sciences R & D. 2472555218766278. PMID 29562800 DOI: 10.1177/2472555218766278  1
2017 Kaniskan HÜ, Eram MS, Zhao K, Szewczyk MM, Yang X, Schmidt K, Luo X, Xiao S, Dai M, He F, Zang I, Lin Y, Li F, Dobrovetsky E, Smil D, ... ... Arrowsmith CH, et al. Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of Medicinal Chemistry. PMID 29244490 DOI: 10.1021/Acs.Jmedchem.7B01674  1
2017 Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N, Meier JL, Arrowsmith CH, Brown PJ, Baell JB, Walters MA. Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nature Communications. 8: 1527. PMID 29142305 DOI: 10.1038/S41467-017-01657-3  1
2017 Houliston RS, Lemak A, Iqbal A, Ivanochko D, Duan S, Kaustov L, Ong MS, Fan L, Senisterra G, Brown PJ, Wang YX, Arrowsmith CH. Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability. The Journal of Biological Chemistry. PMID 29074623 DOI: 10.1074/jbc.M117.799700  1
2017 Schapira M, Tyers M, Torrent M, Arrowsmith CH. WD40 repeat domain proteins: a novel target class? Nature Reviews. Drug Discovery. PMID 29026209 DOI: 10.1038/Nrd.2017.179  1
2017 Harding RJ, Ferreira de Freitas R, Collins PM, Franzoni I, Ravichandran M, Ouyang H, Juarez-Ornelas KA, Lautens M, Schapira M, von Delft F, Santhakumar V, Arrowsmith CH. Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin. Journal of Medicinal Chemistry. PMID 29019676 DOI: 10.1021/Acs.Jmedchem.7B00933  1
2017 Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, et al. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Cancer Cell. 32: 460-473.e6. PMID 29017057 DOI: 10.1016/J.Ccell.2017.09.007  0.01
2017 Liang Y, Ahmed M, Guo H, Soares F, Hua JT, Gao S, Lu C, Poon C, Han W, Langstein J, Ekram MB, Li B, Davicioni E, Takhar M, Erho N, ... ... Arrowsmith CH, et al. LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression. Cancer Research. PMID 28916652 DOI: 10.1158/0008-5472.Can-17-0496  0.01
2017 Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, ... ... Arrowsmith CH, et al. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell. 21: 411. PMID 28886368 DOI: 10.1016/j.stem.2017.08.008  1
2017 Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, ... ... Arrowsmith CH, et al. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature. PMID 28854171 DOI: 10.1038/Nature23666  1
2017 He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, ... ... Arrowsmith CH, et al. Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature Chemical Biology. 13: 922. PMID 28853738 DOI: 10.1038/nchembio0817-922b  1
2017 Xu Z, Stogios PJ, Quaile A, Forsberg K, Patel S, Skarina T, Houliston S, Arrowsmith C, Dantas G, Savchenko A. Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Novel Functionality of Resistance Enzymes. Acs Infectious Diseases. PMID 28756664 DOI: 10.1021/Acsinfecdis.7B00068  1
2017 Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, ... ... Arrowsmith CH, et al. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell. PMID 28712938 DOI: 10.1016/J.Stem.2017.06.004  1
2017 Rocklin GJ, Chidyausiku TM, Goreshnik I, Ford A, Houliston S, Lemak A, Carter L, Ravichandran R, Mulligan VK, Chevalier A, Arrowsmith CH, Baker D. Global analysis of protein folding using massively parallel design, synthesis, and testing. Science (New York, N.Y.). 357: 168-175. PMID 28706065 DOI: 10.1126/Science.Aan0693  1
2017 Xiong Y, Li F, Babault N, Wu H, Dong A, Zeng H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorganic & Medicinal Chemistry. PMID 28662962 DOI: 10.1016/J.Bmc.2017.06.021  1
2017 Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE. The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage. Elife. 6. PMID 28406400 DOI: 10.7554/Elife.23872  1
2017 Wyatt HD, Laister RC, Martin SR, Arrowsmith CH, West SC. The SMX DNA Repair Tri-nuclease. Molecular Cell. 65: 848-860.e11. PMID 28257701 DOI: 10.1016/J.Molcel.2017.01.031  1
2017 Barnash KD, The J, Norris-Drouin JL, Cholensky SH, Worley BM, Li F, Stuckey JI, Brown PJ, Vedadi M, Arrowsmith CH, Frye SV, James LI. Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. Acs Combinatorial Science. PMID 28165227 DOI: 10.1021/acscombsci.6b00174  1
2017 Vedadi M, Blazer L, Eram MS, Barsyte-Lovejoy D, Arrowsmith CH, Hajian T. Targeting human SET1/MLL family of proteins. Protein Science : a Publication of the Protein Society. PMID 28160335 DOI: 10.1002/pro.3129  1
2017 Grondin JM, Duan D, Kirlin AC, Abe KT, Chitayat S, Spencer HL, Spencer C, Campigotto A, Houliston S, Arrowsmith CH, Allingham JS, Boraston AB, Smith SP. Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens. Plos One. 12: e0171606. PMID 28158290 DOI: 10.1371/Journal.Pone.0171606  1
2017 He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, ... ... Arrowsmith CH, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nature Chemical Biology. PMID 28135237 DOI: 10.1038/Nchembio.2306  1
2017 Xiong Y, Li F, Babault N, Dong A, Zeng H, Wu H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J. Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. Journal of Medicinal Chemistry. PMID 28135087 DOI: 10.1021/Acs.Jmedchem.6B01645  1
2017 Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, ... ... Arrowsmith CH, et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nature Chemical Biology. PMID 28114273 DOI: 10.1038/Nchembio.2282  1
2017 Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, et al. Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma. Cancer Cell. 31: 50-63. PMID 28073004 DOI: 10.1016/J.Ccell.2016.12.002  1
2017 Valleau D, Houliston S, Lemak A, Anderson WF, Arrowsmith C, Savchenko A. Solution structure of the N-terminal domain of the effector NleG5-1 from Escherichia coli O157:H7 str. Sakai Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6B3N/Pdb  1
2017 Hartung IV, Arrowsmith C, Badock V, Barak N, Berger M, Brown PJ, Christ CD, Eggert E, Egner U, Fedorov O, Fernandez-Montalvan AE, Gorjanacz M, Haegebarth A, Haendler B, Hillig RC, et al. Abstract 5239: Probing the cancer epigenome: empowering target validation by open innovation Cancer Research. 77: 5239-5239. DOI: 10.1158/1538-7445.Am2017-5239  1
2016 Scheer S, Medina TS, Murison A, Taves MD, Antignano F, Chenery A, Soma KK, Perona-Wright G, Lupien M, Arrowsmith CH, De Carvalho DD, Zaph C. Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation. Journal of Leukocyte Biology. PMID 28034915 DOI: 10.1189/Jlb.3Ma0716-334Rr  1
2016 Torchia J, Golbourn B, Feng S, Ho KC, Sin-Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong-Quang DA, ... ... Arrowsmith CH, et al. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell. 30: 891-908. PMID 27960086 DOI: 10.1016/J.Ccell.2016.11.003  1
2016 Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin J. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. Journal of Medicinal Chemistry. PMID 27804297 DOI: 10.1021/Acs.Jmedchem.6B01244  1
2016 Korzhnev DM, Neculai D, Dhe-Paganon S, Arrowsmith CH, Bezsonova I. Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins. Journal of Biomolecular Nmr. PMID 27771863 DOI: 10.1007/s10858-016-0070-9  1
2016 Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, et al. Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1. Elife. 5. PMID 27595565 DOI: 10.7554/Elife.17101  1
2016 Shen Y, Szewczyk MM, Eram MS, Smil D, Kaniskan HÜ, de Freitas RF, Senisterra G, Li F, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J. Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry. PMID 27584694 DOI: 10.1021/Acs.Jmedchem.6B01033  1
2016 Blazer LL, Li F, Kennedy S, Zheng YG, Arrowsmith CH, Vedadi M. A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D. Journal of Biomolecular Screening. PMID 27581605 DOI: 10.1177/1087057116666276  1
2016 Kagoya Y, Nakatsugawa M, Yamashita Y, Ochi T, Guo T, Anczurowski M, Saso K, Butler MO, Arrowsmith CH, Hirano N. BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models. The Journal of Clinical Investigation. PMID 27548527 DOI: 10.1172/JCI86437  1
2016 Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Correction to Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of Medicinal Chemistry. PMID 27486787 DOI: 10.1021/Acs.Jmedchem.6B01095  1
2016 Yang X, Li F, Konze KD, Meslamani J, Ma A, Brown PJ, Zhou MM, Arrowsmith CH, Kaniskan HÜ, Vedadi M, Jin J. Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors. Journal of Medicinal Chemistry. PMID 27468126 DOI: 10.1021/Acs.Jmedchem.6B00855  1
2016 Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of Medicinal Chemistry. PMID 27390919 DOI: 10.1021/Acs.Jmedchem.6B00668  1
2016 Schapira M, Arrowsmith CH. Methyltransferase inhibitors for modulation of the epigenome and beyond. Current Opinion in Chemical Biology. 33: 81-87. PMID 27318562 DOI: 10.1016/j.cbpa.2016.05.030  1
2016 Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, ... ... Arrowsmith CH, et al. Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nature Structural & Molecular Biology. PMID 27294782 DOI: 10.1038/Nsmb.3249  1
2016 Ahmed H, Duan S, Arrowsmith CH, Barsyte-Lovejoy D, Schapira M. An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates. Journal of Proteome Research. PMID 27163177 DOI: 10.1021/acs.jproteome.6b00220  1
2016 Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M. PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase. The Journal of Biological Chemistry. PMID 27129774 DOI: 10.1074/jbc.M116.721472  1
2016 Eggert E, Hillig RC, Köhr S, Stöckigt D, Weiske J, Barak N, Mowat J, Brumby T, Christ CD, Ter Laak A, Lang T, Fernández-Montalván AE, Badock V, Weinmann H, Hartung IV, ... ... Arrowsmith CH, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. Journal of Medicinal Chemistry. PMID 27075367 DOI: 10.1021/acs.jmedchem.5b01890  1
2016 Oudhoff MJ, Braam MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, et al. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling. Developmental Cell. 37: 47-57. PMID 27046831 DOI: 10.1016/j.devcel.2016.03.002  1
2016 Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut P, Kaznowska EB, Arrowsmith CH, Khatri P, Stresemann C, Gozani O, Sage J. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes & Development. PMID 26988419 DOI: 10.1101/Gad.275529.115  1
2016 Getlik M, Smil D, Zepeda-Velázquez C, Bolshan Y, Poda G, Wu H, Dong A, Kuznetsova E, Marcellus R, Senisterra G, Dombrovski L, Hajian T, Kiyota T, Schapira M, Arrowsmith CH, et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry. PMID 26958703 DOI: 10.1021/Acs.Jmedchem.5B01630  1
2016 Ferreira de Freitas R, Eram MS, Szewczyk MM, Steuber H, Smil D, Wu H, Li F, Senisterra G, Dong A, Brown PJ, Hitchcock M, Moosmayer D, Stegmann CM, Egner U, Arrowsmith C, et al. Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of Medicinal Chemistry. PMID 26824386 DOI: 10.1021/Acs.Jmedchem.5B01772  1
2016 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, ... ... Arrowsmith CH, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 26807715 DOI: 10.1038/Nchembio.2007  1
2016 Huang L, Holtzinger A, Jagan I, Nostro C, Wang R, Muthuswamy L, Arrowsmith C, Cleary S, Schaeffer D, Roehrl M, Ming-Sound T, Gallinger S, Keller G, Muthuswamy S. Abstract B45: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B45  1
2016 Kaniskan H, Eram MS, Liu J, Smil D, Martini ML, Shen Y, Santhakumar V, Brown PJ, Arrowsmith CH, Vedadi M, Jin J. Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1) Medchemcomm. 7: 1793-1796. DOI: 10.1039/c6md00342g  1
2016 Pourali SH, Arrowsmith C, Chrisman N, Matkan AA, Mitchell D. Topography Wetness Index Application in Flood-Risk-Based Land Use Planning Applied Spatial Analysis and Policy. 9: 39-54. DOI: 10.1007/s12061-014-9130-2  1
2015 Li F, Kennedy S, Hajian T, Gibson E, Seitova A, Xu C, Arrowsmith CH, Vedadi M. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Journal of Biomolecular Screening. PMID 26701100 DOI: 10.1177/1087057115623264  1
2015 Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, ... ... Arrowsmith CH, et al. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. Cancer Cell. PMID 26626085 DOI: 10.1016/J.Ccell.2015.10.005  1
2015 Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, et al. A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases. Acs Chemical Biology. PMID 26598975 DOI: 10.1021/Acschembio.5B00839  1
2015 Luan Y, Blazer LL, Hu H, Hajian T, Zhang J, Wu H, Houliston S, Arrowsmith CH, Vedadi M, Zheng YG. Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1. Organic & Biomolecular Chemistry. PMID 26541578 DOI: 10.1039/c5ob01794g  1
2015 Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nature Medicine. PMID 26501191 DOI: 10.1038/Nm.3973  1
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. Corrigendum: The promise and peril of chemical probes. Nature Chemical Biology. 11: 887. PMID 26485080 DOI: 10.1038/Nchembio1115-887C  1
2015 Sun Y, Bell JL, Carter DR, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, ... ... Arrowsmith CH, et al. WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma. Cancer Research. PMID 26471359 DOI: 10.1158/0008-5472.Can-15-0423  1
2015 Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, ... ... Arrowsmith CH, et al. Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. Plos One. 10: e0139695. PMID 26437229 DOI: 10.1371/Journal.Pone.0139695  1
2015 Frye SV, Arkin MR, Arrowsmith CH, Conn PJ, Glicksman MA, Hull-Ryde EA, Slusher BS. Tackling reproducibility in academic preclinical drug discovery. Nature Reviews. Drug Discovery. 14: 733-4. PMID 26388229 DOI: 10.1038/Nrd4737  1
2015 Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, ... ... Arrowsmith CH, et al. Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology. 11: 815. PMID 26379026 DOI: 10.1038/nchembio1015-815b  1
2015 Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 525: 206-11. PMID 26331536 DOI: 10.1038/Nature15251  1
2015 Everett J, Tejero R, Murthy SB, Acton TB, Aramini JM, Baran MC, Benach J, Cort JR, Eletsky A, Forouhar F, Guan R, Kuzin AP, Lee HW, Liu G, Mani R, ... ... Arrowsmith CH, et al. A Community Resource of Experimental Data for NMR - X-ray Crystal Structure Pairs. Protein Science : a Publication of the Protein Society. PMID 26293815 DOI: 10.1002/Pro.2774  1
2015 Pozhidaeva AK, Mohni KN, Dhe-Paganon S, Arrowsmith CH, Weller SK, Korzhnev DM, Bezsonova I. Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1. The Journal of Biological Chemistry. 290: 22907-18. PMID 26224631 DOI: 10.1074/Jbc.M115.664805  1
2015 Huston A, Arrowsmith CH, Knapp S, Schapira M. Probing the epigenome. Nature Chemical Biology. 11: 542-5. PMID 26196765 DOI: 10.1038/nchembio.1871  1
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/Nchembio.1867  1
2015 Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, ... ... Arrowsmith CH, et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology. 11: 571-8. PMID 26167872 DOI: 10.1038/Nchembio.1859  1
2015 Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, ... ... Arrowsmith CH, et al. Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods. PMID 26121405 DOI: 10.1038/Nmeth.3472  1
2015 Sweis RF, Wang Z, Algire M, Arrowsmith CH, Brown PJ, Chiang GG, Guo J, Jakob CG, Kennedy S, Li F, Maag D, Shaw B, Soni NB, Vedadi M, Pappano WN. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. Acs Medicinal Chemistry Letters. 6: 695-700. PMID 26101576 DOI: 10.1021/acsmedchemlett.5b00124  1
2015 Rosato A, Vranken W, Fogh RH, Ragan TJ, Tejero R, Pederson K, Lee HW, Prestegard JH, Yee A, Wu B, Lemak A, Houliston S, Arrowsmith CH, Kennedy M, Acton TB, et al. The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013. Journal of Biomolecular Nmr. PMID 26071966 DOI: 10.1007/S10858-015-9953-4  1
2015 Eram MS, Kuznetsova E, Li F, Lima-Fernandes E, Kennedy S, Chau I, Arrowsmith CH, Schapira M, Vedadi M. Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2. Biochimica Et Biophysica Acta. 1850: 1842-8. PMID 26002201 DOI: 10.1016/j.bbagen.2015.05.013  1
2015 Buchko GW, Yee A, Semesi A, Myler PJ, Arrowsmith CH, Hui R. Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum. Acta Crystallographica. Section F, Structural Biology Communications. 71: 514-21. PMID 25945703 DOI: 10.1107/S2053230X1402799X  1
2015 Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Dual PRMT5-PRMT7 Inhibitor. Acs Medicinal Chemistry Letters. 6: 408-12. PMID 25893041 DOI: 10.1021/Ml500467H  1
2015 Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen LH, Curtis C, Emtage S, Fan L, Gheyi T, Li F, Liu S, Martin JR, Mendel D, Olsen JB, Pelletier L, ... ... Arrowsmith CH, et al. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. The Journal of Biological Chemistry. 290: 13641-53. PMID 25825497 DOI: 10.1074/Jbc.M114.626861  1
2015 Tardat M, Albert M, Kunzmann R, Liu Z, Kaustov L, Thierry R, Duan S, Brykczynska U, Arrowsmith CH, Peters AH. Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner. Molecular Cell. 58: 157-71. PMID 25801166 DOI: 10.1016/j.molcel.2015.02.013  1
2015 Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, ... ... Arrowsmith CH, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International Ed. in English). 54: 5166-70. PMID 25728001 DOI: 10.1002/Anie.201412154  1
2015 Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M. Preclinical target validation using patient-derived cells. Nature Reviews. Drug Discovery. 14: 149-50. PMID 25722227 DOI: 10.1038/nrd4565  1
2015 Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. Acs Chemical Biology. 10: 1072-81. PMID 25590533 DOI: 10.1021/Cb500956G  1
2015 Hong JH, Kaustov L, Coyaud E, Srikumar T, Wan J, Arrowsmith C, Raught B. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. Molecular & Cellular Proteomics : McP. 14: 674-85. PMID 25582440 DOI: 10.1074/Mcp.M114.042168  1
2015 Kwan M, Arrowsmith C, Cartwright W. Developing a method for visualizing population movements Geo-Intelligence and Visualization Through Big Data Trends. 205-221. DOI: 10.4018/978-1-4666-8465-2.ch008  1
2015 Holden LD, Silcock DM, Arrowsmith CA, Al Hassani M. Laser scanning for the documentation and management of heritage sites within the Emirate of Fujairah, United Arab Emirates Arabian Archaeology and Epigraphy. 26: 55-67. DOI: 10.1111/aae.12050  1
2015 Tyler JJ, Jones M, Arrowsmith C, Allott T, Leng MJ. Spatial patterns in the oxygen isotope composition of daily rainfall in the British Isles Climate Dynamics. 1-17. DOI: 10.1007/s00382-015-2945-y  1
2015 Poodat F, Arrowsmith C, Fraser D, Gordon A. Prioritizing Urban Habitats for Connectivity Conservation: Integrating Centrality and Ecological Metrics Environmental Management. 56: 664-674. DOI: 10.1007/s00267-015-0520-2  1
2014 Dong C, Zhang H, Xu C, Arrowsmith CH, Min J. Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation. Iucrj. 1: 540-9. PMID 25485134 DOI: 10.1107/S2052252514020922  1
2014 Shah MA, Denton EL, Arrowsmith CH, Lupien M, Schapira M. A global assessment of cancer genomic alterations in epigenetic mechanisms. Epigenetics & Chromatin. 7: 29. PMID 25484917 DOI: 10.1186/1756-8935-7-29  1
2014 Lemak A, Wu B, Yee A, Houliston S, Lee HW, Gutmanas A, Fang X, Garcia M, Semesi A, Wang YX, Prestegard JH, Arrowsmith CH. Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data. Structure (London, England : 1993). 22: 1862-74. PMID 25456817 DOI: 10.1016/j.str.2014.09.013  1
2014 Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, ... ... Arrowsmith CH, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 12853-8. PMID 25136132 DOI: 10.1073/Pnas.1407358111  1
2014 Ma A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin J. Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Journal of Medicinal Chemistry. 57: 6822-33. PMID 25032507 DOI: 10.1021/Jm500871S  1
2014 Eletsky A, Michalska K, Houliston S, Zhang Q, Daily MD, Xu X, Cui H, Yee A, Lemak A, Wu B, Garcia M, Burnet MC, Meyer KM, Aryal UK, Sanchez O, ... ... Arrowsmith CH, et al. Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO. Plos One. 9: e101787. PMID 25010333 DOI: 10.1371/Journal.Pone.0101787  1
2014 Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, ... ... Arrowsmith CH, et al. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nature Structural & Molecular Biology. 21: 686-95. PMID 24997600 DOI: 10.1038/Nsmb.2853  1
2014 Gelato KA, Tauber M, Ong MS, Winter S, Hiragami-Hamada K, Sindlinger J, Lemak A, Bultsma Y, Houliston S, Schwarzer D, Divecha N, Arrowsmith CH, Fischle W. Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. Molecular Cell. 54: 905-19. PMID 24813945 DOI: 10.1016/J.Molcel.2014.04.004  1
2014 Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, ... Arrowsmith CH, et al. Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. The Journal of Clinical Investigation. 124: 1945-55. PMID 24667637 DOI: 10.1172/Jci69592  1
2014 Helander S, Montecchio M, Lemak A, Farès C, Almlöf J, Li Y, Yee A, Arrowsmith CH, Dhe-Paganon S, Sunnerhagen M. Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1. Biochemical and Biophysical Research Communications. 447: 26-31. PMID 24667607 DOI: 10.1016/j.bbrc.2014.03.068  1
2014 Eram MS, Bustos SP, Lima-Fernandes E, Siarheyeva A, Senisterra G, Hajian T, Chau I, Duan S, Wu H, Dombrovski L, Schapira M, Arrowsmith CH, Vedadi M. Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. The Journal of Biological Chemistry. 289: 12177-88. PMID 24634223 DOI: 10.1074/jbc.M113.523183  1
2014 Allali-Hassani A, Kuznetsova E, Hajian T, Wu H, Dombrovski L, Li Y, Gräslund S, Arrowsmith CH, Schapira M, Vedadi M. A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro. Journal of Biomolecular Screening. 19: 928-35. PMID 24595546 DOI: 10.1177/1087057114525854  1
2014 Yee AA, Semesi A, Garcia M, Arrowsmith CH. Screening proteins for NMR suitability. Methods in Molecular Biology (Clifton, N.J.). 1140: 169-78. PMID 24590717 DOI: 10.1007/978-1-4939-0354-2_13  1
2014 Grondin JM, Chitayat S, Ficko-Blean E, Houliston S, Arrowsmith CH, Boraston AB, Smith SP. An unusual mode of galactose recognition by a family 32 carbohydrate-binding module. Journal of Molecular Biology. 426: 869-80. PMID 24326248 DOI: 10.1016/J.Jmb.2013.11.029  1
2014 Kreso A, van Galen P, Pedley NM, Lima-Fernandes E, Frelin C, Davis T, Cao L, Baiazitov R, Du W, Sydorenko N, Moon YC, Gibson L, Wang Y, Leung C, Iscove NN, ... Arrowsmith CH, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nature Medicine. 20: 29-36. PMID 24292392 DOI: 10.1038/Nm.3418  1
2014 Watson M, Chow S, Barsyte D, Arrowsmith C, Shankey TV, Minden M, Hedley D. The study of epigenetic mechanisms based on the analysis of histone modification patterns by flow cytometry. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 85: 78-87. PMID 24038859 DOI: 10.1002/Cyto.A.22344  1
2014 Arrowsmith CSL, Zhu Y. Comparison between 2D and 3D Hydraulic modelling approaches for simulation of vertical slot fishways Ishs 2014 - Hydraulic Structures and Society - Engineering Challenges and Extremes: Proceedings of the 5th Iahr International Symposium On Hydraulic Structures. DOI: 10.14264/uql.2014.49  1
2014 Arrowsmith C, Verhoeven D, Davidson A. Exhibiting the exhibitors: Spatial visualization for heterogeneous cinema venue data Cartographic Journal. 51: 301-312. DOI: 10.1179/1743277414Y.0000000096  1
2014 Pourali H, Arrowsmith C. Assisting local flood management by using conceptual spatial distributed hydrological model Proceedings - 2013 5th International Conference On Geo-Information Technologies For Natural Disaster Management, Git4ndm 2013. 62-72. DOI: 10.1109/GIT4NDM.2013.10  1
2014 Johnson A, Arrowsmith C. Techniques for analysing the relationship between population density and geographical features of interest Ceur Workshop Proceedings. 1307.  1
2014 Arrowsmith C, Bellman C, Cartwright B, Shortis M. Geospatial Science Research 3 (GSR-3) Ceur Workshop Proceedings. 1307.  1
2014 Taylor S, Arrowsmith C, Cook N. A band on every corner: Using historical GIS to describe changes in the Sydney and Melbourne live music scenes Ceur Workshop Proceedings. 1307.  1
2014 Arrowsmith CL, Race G. Spatial assessment of estuary shoreline erosion susceptiblity Hydrology and Water Resources Symposium 2014, Hwrs 2014 - Conference Proceedings. 621-628.  1
2014 Arrowsmith C, Verhoeven D, Davidson A, Coate B. Kinomatics: A global study into cinema data Ceur Workshop Proceedings. 1307.  1
2014 Kiran KC, Chhetri P, Arrowsmith C, Corcoran J. Modelling the spatial pattern of housing-renovation employment in Melbourne, Australia: An application of geographically weighted regression Applied Gis. 10: 1-20.  1
2014 Pourali S, Arrowsmith C, Chrisman N, Matkan A. Vertical accuracy assessment of LiDAR ground points using minimum distance approach Ceur Workshop Proceedings. 1142: 86-96.  1
2013 Bolshan Y, Getlik M, Kuznetsova E, Wasney GA, Hajian T, Poda G, Nguyen KT, Wu H, Dombrovski L, Dong A, Senisterra G, Schapira M, Arrowsmith CH, Brown PJ, Al-Awar R, et al. Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. Acs Medicinal Chemistry Letters. 4: 353-7. PMID 24900672 DOI: 10.1021/Ml300467N  1
2013 Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface. Medchemcomm. 4: 1501-1507. PMID 24466405 DOI: 10.1039/C3Md00197K  1
2013 Wu H, Zeng H, Dong A, Li F, He H, Senisterra G, Seitova A, Duan S, Brown PJ, Vedadi M, Arrowsmith CH, Schapira M. Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One. 8: e83737. PMID 24367611 DOI: 10.1371/journal.pone.0083737  1
2013 Lemak A, Yee A, Wu H, Yap D, Zeng H, Dombrovski L, Houliston S, Aparicio S, Arrowsmith CH. Solution NMR structure and histone binding of the PHD domain of human MLL5. Plos One. 8: e77020. PMID 24130829 DOI: 10.1371/journal.pone.0077020  1
2013 Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of Medicinal Chemistry. 56: 8931-42. PMID 24102134 DOI: 10.1021/Jm401480R  1
2013 James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. Journal of Medicinal Chemistry. 56: 7358-71. PMID 24040942 DOI: 10.1021/jm400919p  1
2013 Pocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G. The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. Plos One. 8: e72446. PMID 24039764 DOI: 10.1371/Journal.Pone.0072446  1
2013 Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, et al. Control of the hippo pathway by Set7-dependent methylation of Yap. Developmental Cell. 26: 188-94. PMID 23850191 DOI: 10.1016/J.Devcel.2013.05.025  1
2013 Rothbart SB, Dickson BM, Ong MS, Krajewski K, Houliston S, Kireev DB, Arrowsmith CH, Strahl BD. Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes & Development. 27: 1288-98. PMID 23752590 DOI: 10.1101/Gad.220467.113  1
2013 Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, ... ... Arrowsmith CH, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34. PMID 23614352 DOI: 10.1021/Cb400133J  1
2013 Sarkari F, Wheaton K, La Delfa A, Mohamed M, Shaikh F, Khatun R, Arrowsmith CH, Frappier L, Saridakis V, Sheng Y. Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1. The Journal of Biological Chemistry. 288: 16975-85. PMID 23603909 DOI: 10.1074/Jbc.M113.469262  1
2013 Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Journal of Medicinal Chemistry. 56: 2110-24. PMID 23445220 DOI: 10.1021/Jm3018332  1
2013 Yu W, Smil D, Li F, Tempel W, Fedorov O, Nguyen KT, Bolshan Y, Al-Awar R, Knapp S, Arrowsmith CH, Vedadi M, Brown PJ, Schapira M. Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorganic & Medicinal Chemistry. 21: 1787-94. PMID 23433670 DOI: 10.1016/J.Bmc.2013.01.049  1
2013 Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Molecular Endocrinology (Baltimore, Md.). 27: 315-24. PMID 23322723 DOI: 10.1210/me.2012-1287  1
2013 James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, ... ... Arrowsmith CH, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature Chemical Biology. 9: 184-91. PMID 23292653 DOI: 10.1038/Nchembio.1157  1
2013 Williams DE, Dalisay DS, Li F, Amphlett J, Maneerat W, Chavez MA, Wang YA, Matainaho T, Yu W, Brown PJ, Arrowsmith CH, Vedadi M, Andersen RJ. Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Organic Letters. 15: 414-7. PMID 23272941 DOI: 10.1021/Ol303416K  1
2013 Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Dong A, Nguyen KT, Smil D, Bolshan Y, Hajian T, He H, Seitova A, Chau I, Li F, ... ... Arrowsmith CH, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. The Biochemical Journal. 449: 151-9. PMID 22989411 DOI: 10.1042/Bj20121280  1
2013 Chhetri A, Arrowsmith C, Chhetri P, Corcoran J. Mapping spatial tourism and hospitality employment clusters: An application of spatial autocorrelation Tourism Analysis. 18: 559-573. DOI: 10.3727/108354213X13782245307830  1
2013 Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, ... ... Arrowsmith CH, et al. Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors Nature Communications. 4. DOI: 10.1038/Ncomms2845  1
2013 Verhoeven D, Arrowsmith C. Mapping the ill-disciplined? Spatial analyses and historical change in the postwar film industry Locating the Moving Image: New Approaches to Film and Place. 106-129.  1
2012 Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, ... ... Arrowsmith CH, et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nature Communications. 3: 1288. PMID 23250418 DOI: 10.1038/Ncomms2304  1
2012 Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature Structural & Molecular Biology. 19: 1155-60. PMID 23022729 DOI: 10.1038/Nsmb.2391  1
2012 Nady N, Krichevsky L, Zhong N, Duan S, Tempel W, Amaya MF, Ravichandran M, Arrowsmith CH. Histone recognition by human malignant brain tumor domains. Journal of Molecular Biology. 423: 702-18. PMID 22954662 DOI: 10.1016/J.Jmb.2012.08.022  1
2012 Mulvaney R, Abram NJ, Hindmarsh RC, Arrowsmith C, Fleet L, Triest J, Sime LC, Alemany O, Foord S. Recent Antarctic Peninsula warming relative to Holocene climate and ice-shelf history. Nature. 489: 141-4. PMID 22914090 DOI: 10.1038/nature11391  1
2012 Yang Y, Ramelot TA, Cort JR, Garcia M, Yee A, Arrowsmith CH, Kennedy MA. Solution NMR structure of hypothetical protein CV_2116 encoded by a viral prophage element in Chromobacterium violaceum. International Journal of Molecular Sciences. 13: 7354-64. PMID 22837698 DOI: 10.3390/Ijms13067354  1
2012 Popovic A, Wu B, Arrowsmith CH, Edwards AM, Davidson AR, Maxwell KL. Structural and biochemical characterization of phage λ FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity. The Journal of Biological Chemistry. 287: 32085-95. PMID 22801427 DOI: 10.1074/jbc.M112.378349  1
2012 Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, ... ... Arrowsmith CH, et al. An allosteric inhibitor of protein arginine methyltransferase 3. Structure (London, England : 1993). 20: 1425-35. PMID 22795084 DOI: 10.1016/J.Str.2012.06.001  1
2012 Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D. Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Molecular Cell. 47: 383-95. PMID 22742833 DOI: 10.1016/J.Molcel.2012.05.045  1
2012 Paddan GS, Mansfield NJ, Arrowsmith CI, Rimell AN, King SK, Holmes SR. The influence of seat backrest angle on perceived discomfort during exposure to vertical whole-body vibration. Ergonomics. 55: 923-36. PMID 22651706 DOI: 10.1080/00140139.2012.684889  1
2012 Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, et al. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Science Signaling. 5: ra39. PMID 22649097 DOI: 10.1126/scisignal.2002979  1
2012 Brázda V, Coufal J, Liao JC, Arrowsmith CH. Preferential binding of IFI16 protein to cruciform structure and superhelical DNA. Biochemical and Biophysical Research Communications. 422: 716-20. PMID 22618232 DOI: 10.1016/j.bbrc.2012.05.065  1
2012 Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M. Epigenetic protein families: A new frontier for drug discovery Nature Reviews Drug Discovery. 11: 384-400. PMID 22498752 DOI: 10.1038/nrd3674  1
2012 Sheng Y, Hong JH, Doherty R, Srikumar T, Shloush J, Avvakumov GV, Walker JR, Xue S, Neculai D, Wan JW, Kim SK, Arrowsmith CH, Raught B, Dhe-Paganon S. A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Molecular & Cellular Proteomics : McP. 11: 329-41. PMID 22496338 DOI: 10.1074/Mcp.O111.013706  1
2012 Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 149: 214-31. PMID 22464331 DOI: 10.1016/J.Cell.2012.02.013  1
2012 Andresen C, Helander S, Lemak A, Farès C, Csizmok V, Carlsson J, Penn LZ, Forman-Kay JD, Arrowsmith CH, Lundström P, Sunnerhagen M. Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Research. 40: 6353-66. PMID 22457068 DOI: 10.1093/Nar/Gks263  1
2012 Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P, Gutmanas A, Güntert P, He Y, Herrmann T, Huang YJ, et al. Blind testing of routine, fully automated determination of protein structures from NMR data. Structure (London, England : 1993). 20: 227-36. PMID 22325772 DOI: 10.1016/J.Str.2012.01.002  1
2012 Singer AU, Wu B, Yee A, Houliston S, Xu X, Cui H, Skarina T, Garcia M, Semesi A, Arrowsmith CH, Savchenko A. Structural analysis of HopPmaL reveals the presence of a second adaptor domain common to the HopAB family of Pseudomonas syringae type III effectors. Biochemistry. 51: 1-3. PMID 22191472 DOI: 10.1021/bi2013883  1
2012 Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG. Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. The Journal of Biological Chemistry. 287: 2317-27. PMID 22069321 DOI: 10.1074/Jbc.M111.273730  1
2012 Allali-Hassani A, Wasney GA, Siarheyeva A, Hajian T, Arrowsmith CH, Vedadi M. Fluorescence-based methods for screening writers and readers of histone methyl marks. Journal of Biomolecular Screening. 17: 71-84. PMID 21972038 DOI: 10.1177/1087057111422256  1
2012 Lemak A, Yee A, Houliston S, Garcia M, Dhe-Paganon S, Montelione GT, Arrowsmith C. NMR solution structure of the N-terminal domain of human USP28. Northeast structural genomics consortium target HT8470A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lva/Pdb  1
2012 Bar-Yosef Mayer DE, Leng MJ, Aldridge DC, Arrowsmith C, Gümüş BA, Sloane HJ. Modern and early-middle Holocene shells of the freshwater mollusc Unio, from Çatalhöyük in the Konya Basin, Turkey: Preliminary palaeoclimatic implications from molluscan isotope data Journal of Archaeological Science. 39: 76-83. DOI: 10.1016/j.jas.2011.09.003  1
2012 Cossar JD, Arrowsmith CH. Efficient strategies for production of egbraryotic proteins Comprehensive Biophysics. 1: 4-33. DOI: 10.1016/B978-0-12-374920-8.00104-1  1
2012 Holden L, Silcock D, Arrowsmith C. Mapping cultural and archaeological features in the Fujairah emirate using a terrestrial laser scanner Ceur Workshop Proceedings. 1328.  1
2012 Roychowdhury K, Jones S, Reinke K, Arrowsmith C. Night-time lights and levels of development: A study using DMSP-OLS night time images at the sub-national level International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences - Isprs Archives. 39: 93-98.  1
2012 Elsley M, Cartwright W, Whelan J, Arrowsmith C. Park visitors and web 2.0 - Crowdsourcing in park management? Ceur Workshop Proceedings. 1328.  1
2012 Arrowsmith C, Bellman C, Cartwright B, Reinke K, Shortis M, Soto-Berelov M, Barranco LS. Geospatial science research 2 (GSR-2) Ceur Workshop Proceedings. 1328.  1
2011 Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, ... ... Arrowsmith C, et al. Role of Pirh2 in mediating the regulation of p53 and c-Myc. Plos Genetics. 7: e1002360. PMID 22125490 DOI: 10.1371/Journal.Pgen.1002360  1
2011 Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH. Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A. Journal of Biomolecular Nmr. 51: 185-90. PMID 21947926 DOI: 10.1007/s10858-011-9552-y  1
2011 Espinosa A, Hennig J, Ambrosi A, Anandapadmanaban M, Abelius MS, Sheng Y, Nyberg F, Arrowsmith CH, Sunnerhagen M, Wahren-Herlenius M. Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface. The Journal of Biological Chemistry. 286: 36478-91. PMID 21862588 DOI: 10.1074/Jbc.M111.241786  1
2011 Brázda V, Laister RC, Jagelská EB, Arrowsmith C. Cruciform structures are a common DNA feature important for regulating biological processes. Bmc Molecular Biology. 12: 33. PMID 21816114 DOI: 10.1186/1471-2199-12-33  1
2011 Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 54: 6139-50. PMID 21780790 DOI: 10.1021/jm200903z  1
2011 Yoo J, Ko S, Kim H, Sampson H, Yun JH, Choe KM, Chang I, Arrowsmith CH, Krause HM, Cho HS, Lee W. Crystal structure of Fushi tarazu factor 1 ligand binding domain/Fushi tarazu peptide complex identifies new class of nuclear receptors. The Journal of Biological Chemistry. 286: 31225-31. PMID 21775434 DOI: 10.1074/jbc.M111.252916  1
2011 Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, ... ... Arrowsmith CH, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature Chemical Biology. 7: 566-74. PMID 21743462 DOI: 10.1038/Nchembio.599  1
2011 Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chédin F, Arrowsmith CH, Dhe-Paganon S. Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. The Journal of Biological Chemistry. 286: 24300-11. PMID 21489993 DOI: 10.1074/Jbc.M111.234104  1
2011 Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, et al. Small-molecule ligands of methyl-lysine binding proteins. Journal of Medicinal Chemistry. 54: 2504-11. PMID 21417280 DOI: 10.1021/jm200045v  1
2011 Liao JC, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, Xiao T, Tempel W, Zuo X, Wang YX, Chirgadze NY, Arrowsmith CH. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure (London, England : 1993). 19: 418-29. PMID 21397192 DOI: 10.1016/j.str.2010.12.015  1
2011 Ko S, Kim H, Yun J, Yee A, Arrowsmith CH, Cheong C, Lee W. Solution structure of MTH1821, a putative structure homologue to RNA polymerase α subunit from Methanobacterium thermoautotrophicum. Proteins. 79: 1347-51. PMID 21387412 DOI: 10.1002/prot.22956  1
2011 Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 117: 2451-9. PMID 21190999 DOI: 10.1182/Blood-2010-11-321208  1
2011 Lemak A, Gutmanas A, Chitayat S, Karra M, Farès C, Sunnerhagen M, Arrowsmith CH. A novel strategy for NMR resonance assignment and protein structure determination. Journal of Biomolecular Nmr. 49: 27-38. PMID 21161328 DOI: 10.1007/s10858-010-9458-0  1
2011 Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH. Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. The Journal of Biological Chemistry. 286: 4796-808. PMID 21084285 DOI: 10.1074/Jbc.M110.157669  1
2011 Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH. Recognition and specificity determinants of the human cbx chromodomains. The Journal of Biological Chemistry. 286: 521-9. PMID 21047797 DOI: 10.1074/Jbc.M110.191411  1
2011 Lemak A, Srisailam S, Lukin J, Yee A, Montecchio M, Semesi A, Arrowsmith C. Solution NMR structure of holo acyl carrier protein NE2163 from nitrosomonas europaea. Northeast structural genomics consortium target NET1 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lki/Pdb  1
2011 Lemak A, Yee A, Houliston S, Garcia M, Chitayat S, Dhe-Paganon S, Montelione GT, Arrowsmith C. Solution NMR structure of N-terminal domain of human E3 ubiquitin-protein ligase HECW2. Northeast structural genomics consortium (NESG) target ht6306a Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lfe/Pdb  1
2011 Lemak A, Yee A, Houliston S, Garcia M, Daniels C, Savchenko A, Arrowsmith C, Montelione GT. Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lez/Pdb  1
2011 Roychowdhury K, Jones S, Arrowsmith C, Reinke K. Indian census using satellite images: Can DMSP-OLS data be used for small administrative regions? 2011 Joint Urban Remote Sensing Event, Jurse 2011 - Proceedings. 153-156. DOI: 10.1109/JURSE.2011.5764742  1
2011 Roychowdhury K, Jones SD, Arrowsmith C, Reinke K. A comparison of high and low gain DMSP/OLS satellite images for the study of socio-economic metrics Ieee Journal of Selected Topics in Applied Earth Observations and Remote Sensing. 4: 35-42. DOI: 10.1109/JSTARS.2010.2053022  1
2011 Dejbakhsh S, Arrowsmith C, Jackson M. Cultural influence on spatial behaviour Tourism Geographies. 13: 91-111. DOI: 10.1080/14616688.2010.516396  1
2011 Arrowsmith C, Bagoly-Simó P, Finchum A, Oda K, Pawson E. Student employability and its implications for geography curricula and learning practices Journal of Geography in Higher Education. 35: 365-377. DOI: 10.1080/03098265.2011.563379  1
2011 Abram NJ, Mulvaney R, Arrowsmith C. Environmental signals in a highly resolved ice core from James Ross Island, Antarctica Journal of Geophysical Research Atmospheres. 116. DOI: 10.1029/2011JD016147  1
2010 Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, et al. Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity. The Journal of Biological Chemistry. 285: 36070-80. PMID 20826778 DOI: 10.1074/Jbc.M110.145219  1
2010 Sarkari F, La Delfa A, Arrowsmith CH, Frappier L, Sheng Y, Saridakis V. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. Journal of Molecular Biology. 402: 825-37. PMID 20713061 DOI: 10.1016/J.Jmb.2010.08.017  1
2010 Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, ... Arrowsmith CH, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 53: 5844-57. PMID 20614940 DOI: 10.1021/Jm100478Y  1
2010 Wu B, Skarina T, Yee A, Jobin MC, Dileo R, Semesi A, Fares C, Lemak A, Coombes BK, Arrowsmith CH, Singer AU, Savchenko A. NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. Plos Pathogens. 6: e1000960. PMID 20585566 DOI: 10.1371/Journal.Ppat.1000960  1
2010 Vedadi M, Arrowsmith CH, Allali-Hassani A, Senisterra G, Wasney GA. Biophysical characterization of recombinant proteins: a key to higher structural genomics success. Journal of Structural Biology. 172: 107-19. PMID 20466062 DOI: 10.1016/j.jsb.2010.05.005  1
2010 Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD, Privé GG, et al. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 17: 400-11. PMID 20385364 DOI: 10.1016/J.Ccr.2009.12.050  1
2010 Chitayat S, Arrowsmith CH. Four p(53)s in a pod. Nature Structural & Molecular Biology. 17: 390-1. PMID 20368720 DOI: 10.1038/nsmb0410-390  1
2010 Koulov AV, LaPointe P, Lu B, Razvi A, Coppinger J, Dong MQ, Matteson J, Laister R, Arrowsmith C, Yates JR, Balch WE. Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. Molecular Biology of the Cell. 21: 871-84. PMID 20089831 DOI: 10.1091/Mbc.E09-12-1017  1
2010 Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M. Structural biology of human H3K9 methyltransferases. Plos One. 5: e8570. PMID 20084102 DOI: 10.1371/journal.pone.0008570  1
2010 Wigle TJ, Herold JM, Senisterra GA, Vedadi M, Kireev DB, Arrowsmith CH, Frye SV, Janzen WP. Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins. Journal of Biomolecular Screening. 15: 62-71. PMID 20008125 DOI: 10.1177/1087057109352902  1
2010 Chhetri P, Corcoran J, Arrowsmith C. Investigating the temporal dynamics of tourist movement: An application of circular statistics Tourism Analysis. 15: 71-88. DOI: 10.3727/108354210X12724734223676  1
2010 Bezsonova I, Neculai D, Korzhnev D, Weigelt J, Bountra C, Edwards A, Arrowsmith C, Dhe-Paganon S. NMR structure of the HLTF HIRAN domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2L1I/Pdb  1
2010 Kaustov L, Lemak A, Fares C, Gutmanas A, Quang H, Loppnau P, Min J, Edwards A, Arrowsmith C. Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2L11/Pdb  1
2010 Bezsonova I, Lemak A, Avvakumov G, Xue S, Dhe-Paganon S, Montelione GT, Arrowsmith C. Solution NMR structure of human ubiquitin specific protease Usp7 UBL domain (residues 537-664). NESG target hr4395c/ SGC-Toronto Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kvr/Pdb  1
2010 Gutmanas A, Fares C, Yee A, Lemak A, Semesi A, Arrowsmith C. Solution NMR structure of uncharacterized protein CV0863 from Chromobacterium violaceum. NESG target CvT3. OCSP target CV0863. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16790  1
2010 Laister R, Wu B, Lemak A, Arrowsmith C. Solution NMR structure of the Mus81 N-terminal HhH. Northeast Structural Genomics Consortium target MmT1A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16549  1
2010 Xia J(, Evans FH, Spilsbury K, Ciesielski V, Arrowsmith C, Wright G. Market segments based on the dominant movement patterns of tourists Tourism Management. 31: 464-469. DOI: 10.1016/j.tourman.2009.04.013  1
2009 Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, ... Arrowsmith CH, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. Journal of Medicinal Chemistry. 52: 7950-3. PMID 19891491 DOI: 10.1021/Jm901543M  1
2009 Das R, André I, Shen Y, Wu Y, Lemak A, Bansal S, Arrowsmith CH, Szyperski T, Baker D. Simultaneous prediction of protein folding and docking at high resolution. Proceedings of the National Academy of Sciences of the United States of America. 106: 18978-83. PMID 19864631 DOI: 10.1073/Pnas.0904407106  1
2009 Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH. Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins Biochemistry. 48: 10542-10548. PMID 19791798 DOI: 10.1021/bi901131u  1
2009 Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, Park HW, Schapira M, Vedadi M. A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity Biochemical Journal. 424: 15-26. PMID 19702579 DOI: 10.1042/Bj20090723  1
2009 Brázda V, Jagelska EB, Liao JC, Arrowsmith CH. The central region of BRCA1 binds preferentially to supercoiled DNA. Journal of Biomolecular Structure & Dynamics. 27: 97-104. PMID 19492866 DOI: 10.1080/07391102.2009.10507299  1
2009 Montelione GT, Arrowsmith C, Girvin ME, Kennedy MA, Markley JL, Powers R, Prestegard JH, Szyperski T. Unique opportunities for NMR methods in structural genomics. Journal of Structural and Functional Genomics. 10: 101-6. PMID 19288278 DOI: 10.1007/S10969-009-9064-0  1
2009 Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Research. 37: 2204-10. PMID 19233876 DOI: 10.1093/Nar/Gkp086  1
2009 Lemak A, Yee A, Lee H, Semesi A, Prestegard J, Montelione GT, Arrowsmith C. Solution structure of protein CV0426 from Chromobacterium violaceum, Northeast structural genomics consortium (NESG) target CVT2 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kp6/Pdb  1
2009 Lemak A, Yee A, Wu B, Karra M, Ramelot T, Fares C, Semesi A, Kennedy M, Montelione GT, Arrowsmith C. Solution NMR structure of protein AF2094 from Archaeoglobus fulgidus. Northeast Structural Genomics Consotium (NESG) target GT2 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kk4/Pdb  1
2009 Wu B, Yee A, Fares C, Lemak A, Semest A, Arrowsmith C. Solution structure of DnaK suppressor protein from Agrobacterium tumefaciens C58. Northeast Structural Genomics Consortium target AtT12/Ontario Center for Structural Proteomics Target atc0888 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16594  1
2009 Gutmanas A, Yee A, Lemak A, Fares C, Semesi A, Arrowsmith C. Solution structure of protein Atu0922 from A. tumefaciens. Northeast Structural Genomics Consortium target AtT13. Ontario Center for Structural Proteomics target ATC0905. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16476  1
2009 Wu B, Yee A, Fares C, Lemak A, Semest A, Claude M, Singer A, Edwards A, Savchenko A, Arrowsmith C. Solution Structure of C-terminal domain of oxidized NleG2-3 (residue 90-191) from Pathogenic E. coli O157:H7. Northeast Structural Genomics Consortium and Midwest Center for Structural Genomics target ET109A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16374  1
2009 Eletsky A, Wu Y, Yee A, Fares C, Lee H, Prestegard J, Arrowsmith C, Szyperski T. Solution NMR structure of tungsten formylmethanofuran dehydrogenase subunit D from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium target AtT7 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16267  1
2009 Gutmanas A, Yee A, Lemak A, Fares C, Guido V, Arrowsmith C. Zn finger protein YBIL from E.Coli; NESG target ET107; OCSP target EC0402 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16214  1
2009 Lemak A, Gutmanas A, Fares C, Quyang H, Dhe-Paganon S, Montelione G, Arrowsmith C. Solution NMR structure of protein HS00059 from Homo Sapiens. Northeast Structural Genomics Consortium (NESG) target HT98A. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16155  1
2009 Buchko G, Yee A, Semesi A, Hui R, Arrowsmith C. Solution structure of PFE0790c, a putative bolA-like protein from the protozoan parasite Plasmodium falciparum: A Structural Genomics Center for Infectious Disease (SSGCID) community request. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16118  1
2009 Wu B, Yee A, Lemak A, Cort J, Semest A, Kenney M, Arrowsmith C. Solution NMR Structure of protein hp1203 from Helicobacter pylori 26695 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15661  1
2009 Wu B, Yee A, Lemak A, Cort J, Bansal S, Semest A, Guido V, Kennedy M, Prestegard J, Arrowsmith C. A novel domain-swapped solution NMR structure of protein RPA2121 from Rhodopseudomonas palustris Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15324  1
2009 Ai X, Semesi A, Yee A, Arrowsmith C, Li S, Choy W. chemical shift assignments of PA4090 from Pseudomonas aeruginosa Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15246  1
2009 Cerchietti LC, Ghetu A, Zhu X, Silva GD, Zhong S, Matthews M, Polo J, Farès C, Arrowsmith C, Bunting K, Coop A, MacKerell A, Privè G, Melnick A. Abstract B236: A small molecule disrupts the BCL6 transcriptional repressor complex and kills lymphoma cells in vitro and in vivo Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B236  1
2009 Roychowdhury K, Jones S, Arrowsmith C. Assessing the utility of DMSP/OLS night-time images for characterizing Indian urbanization 2009 Joint Urban Remote Sensing Event. DOI: 10.1109/URS.2009.5137620  1
2009 Thomas ER, Wolff EW, Mulvaney R, Johnsen SJ, Steffensen JP, Arrowsmith C. Anatomy of a Dansgaard-Oeschger warming transition: High-resolution analysis of the North Greenland Ice Core Project ice core Journal of Geophysical Research Atmospheres. 114. DOI: 10.1029/2008JD011215  1
2009 Xia J(, Zeephongsekul P, Arrowsmith C. Modelling spatio-temporal movement of tourists using finite Markov chains Mathematics and Computers in Simulation. 79: 1544-1553. DOI: 10.1016/j.matcom.2008.06.007  1
2009 Jonsson CE, Leng MJ, Rosqvist GC, Seibert J, Arrowsmith C. Stable oxygen and hydrogen isotopes in sub-Arctic lake waters from northern Sweden Journal of Hydrology. 376: 143-151. DOI: 10.1016/j.jhydrol.2009.07.021  1
2009 Robinson ZP, Fairchild IJ, Arrowsmith C. Stable isotope tracers of shallow groundwater recharge dynamics and mixing within an Icelandic sandur, Skeiarársandur Iahs-Aish Publication. 119-125.  1
2008 Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH. Molecular basis of Pirh2-mediated p53 ubiquitylation. Nature Structural & Molecular Biology. 15: 1334-42. PMID 19043414 DOI: 10.1038/Nsmb.1521  1
2008 Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, et al. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Molecular Cell. 32: 259-75. PMID 18951093 DOI: 10.1016/J.Molcel.2008.10.002  1
2008 Avvakumov GV, Walker JR, Xue S, Li Y, Duan S, Bronner C, Arrowsmith CH, Dhe-Paganon S. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature. 455: 822-5. PMID 18772889 DOI: 10.1038/nature07273  1
2008 Proudfoot M, Kuznetsova E, Sanders SA, Gonzalez CF, Brown G, Edwards AM, Arrowsmith CH, Yakunin AF. High throughput screening of purified proteins for enzymatic activity. Methods in Molecular Biology (Clifton, N.J.). 426: 331-41. PMID 18542874 DOI: 10.1007/978-1-60327-058-8_21  1
2008 Nady N, Min J, Kareta MS, Chédin F, Arrowsmith CH. A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research. Trends in Biochemical Sciences. 33: 305-13. PMID 18538573 DOI: 10.1016/J.Tibs.2008.04.014  1
2008 Lemak A, Steren CA, Arrowsmith CH, Llinás M. Sequence specific resonance assignment via Multicanonical Monte Carlo search using an ABACUS approach. Journal of Biomolecular Nmr. 41: 29-41. PMID 18458824 DOI: 10.1007/S10858-008-9238-2  1
2008 Shen Y, Lange O, Delaglio F, Rossi P, Aramini JM, Liu G, Eletsky A, Wu Y, Singarapu KK, Lemak A, Ignatchenko A, Arrowsmith CH, Szyperski T, Montelione GT, Baker D, et al. Consistent blind protein structure generation from NMR chemical shift data. Proceedings of the National Academy of Sciences of the United States of America. 105: 4685-90. PMID 18326625 DOI: 10.1073/Pnas.0800256105  1
2008 Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. The Journal of Biological Chemistry. 283: 11355-63. PMID 18285338 DOI: 10.1074/Jbc.M707362200  1
2008 Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, et al. Protein production and purification. Nature Methods. 5: 135-46. PMID 18235434 DOI: 10.1038/Nmeth.F.202  1
2008 Wu B, Yee A, Huang YJ, Ramelot TA, Cort JR, Semesi A, Jung JW, Lee W, Montelione GT, Kennedy MA, Arrowsmith CH. The solution structure of ribosomal protein S17E from Methanobacterium thermoautotrophicum: a structural homolog of the FF domain. Protein Science : a Publication of the Protein Society. 17: 583-8. PMID 18218711 DOI: 10.1110/Ps.073272208  1
2008 Wu B, Lukin J, Yee A, Lemak A, Semesi A, Ramelot TA, Kennedy MA, Arrowsmith CH. Solution structure of ribosomal protein L40E, a unique C4 zinc finger protein encoded by archaeon Sulfolobus solfataricus. Protein Science : a Publication of the Protein Society. 17: 589-96. PMID 18218710 DOI: 10.1110/Ps.073273008  1
2008 Ai X, Semesi A, Yee A, Arrowsmith CH, Choy WY, Li SS. The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin-like fold. Protein Science : a Publication of the Protein Society. 17: 154-8. PMID 18042676 DOI: 10.1110/ps.073167408  1
2008 Proudfoot M, Sanders SA, Singer A, Zhang R, Brown G, Binkowski A, Xu L, Lukin JA, Murzin AG, Joachimiak A, Arrowsmith CH, Edwards AM, Savchenko AV, Yakunin AF. Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain. Journal of Molecular Biology. 375: 301-15. PMID 18021800 DOI: 10.1016/j.jmb.2007.10.060  1
2008 Lemak A, Srisailam S, Yee A, Bansal S, Semesi A, Prestegard J, Montelione GT, Arrowsmith C. Solution NMR structure of protein ATU0232 from AGROBACTERIUM TUMEFACIENS. Northeast Structural Genomics Consortium (NESG) target AtT3. Ontario Center for Structural Proteomics target ATC0223. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K7I/Pdb  1
2008 Wu Y, Singarapu K, Semesi A, Yee A, Bansal S, Prestegard J, Arrowsmith C, Szyperski T, Montelione GT. Solution structure of protein yiiF from Shigella flexneri serotype 5b (strain 8401) . Northeast Structural Genomics Consortium target sft1 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K5J/Pdb  1
2008 Wu Y, Singarapu K, Semesi A, Sukumaran D, Yee A, Garcia M, Arrowsmith C, Szyperski T, Montelione GT. Solution NMR structure of protein encoded by MTH693 from Methanobacterium thermoautotrophicum: Northeast Structural Genomics Consortium target tt824a Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K5H/Pdb  1
2008 Lemak A, Sheng Y, Karra M, Srisailam S, Laister R, Duan S, Arrowsmith C. solution struture of human C-terminal domain of pirh2/Northeast Structural Genomics Consortium (NESG) target HT2C Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15701  1
2008 Ramelot T, Cort J, Semesi A, Garcia M, Yee A, Arrowsmith C, Kennedy M. NMR solution structure of TnpE protein from Shigella flexneri.Northeast Structural Genomics Target SfR125. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr11017  1
2008 Chhetri P, Arrowsmith C. GIS-based modelling of recreational potential of nature-based tourist destinations Tourism Geographies. 10: 233-257. DOI: 10.1080/14616680802000089  1
2008 Arrowsmith C. Supporting the business strategy Reward Governance For Senior Executives. 132-153. DOI: 10.1017/CBO9780511494734.007  1
2008 Arrowsmith C, McNeil R. Reward governance for senior executives Reward Governance For Senior Executives. 1-247. DOI: 10.1017/CBO9780511494734  1
2008 Xia J(, Arrowsmith C, Jackson M, Cartwright W. The wayfinding process relationships between decision-making and landmark utility Tourism Management. 29: 445-457. DOI: 10.1016/j.tourman.2007.05.010  1
2007 Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. L3MBTL1 recognition of mono- and dimethylated histones. Nature Structural & Molecular Biology. 14: 1229-30. PMID 18026117 DOI: 10.1038/Nsmb1340  1
2007 Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, ... ... Arrowsmith C, et al. In situ proteolysis for protein crystallization and structure determination. Nature Methods. 4: 1019-21. PMID 17982461 DOI: 10.1038/Nmeth1118  1
2007 Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ. CUL7 is a novel antiapoptotic oncogene. Cancer Research. 67: 9616-22. PMID 17942889 DOI: 10.1158/0008-5472.Can-07-0644  1
2007 Wang X, Srisailam S, Yee AA, Lemak A, Arrowsmith C, Prestegard JH, Tian F. Domain-domain motions in proteins from time-modulated pseudocontact shifts. Journal of Biomolecular Nmr. 39: 53-61. PMID 17657568 DOI: 10.1007/S10858-007-9174-6  1
2007 Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY. Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold. Journal of Biomolecular Nmr. 38: 353-8. PMID 17610131 DOI: 10.1007/s10858-007-9172-8  1
2007 Monleón D, Yee A, Arrowsmith C, Celda B. NMR structure of hypothetical protein TA0938 from Thermoplasma acidophilum. Proteins. 67: 1185-8. PMID 17377985 DOI: 10.1002/Prot.21143  1
2007 Kaustov L, Lukin J, Lemak A, Duan S, Ho M, Doherty R, Penn LZ, Arrowsmith CH. The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. The Journal of Biological Chemistry. 282: 11300-7. PMID 17298945 DOI: 10.1074/Jbc.M611297200  1
2007 Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovsky L, Pan PW, Vedadi M, Plotnikov AN, Edwards A, Arrowsmith C, Thornton JM. Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family. Bioinformatics (Oxford, England). 23: e104-9. PMID 17237076 DOI: 10.1093/Bioinformatics/Btl292  1
2007 Ai X, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY. Backbone and side chain 1H, 13C, and 15N resonance assignments of AF2241 from Archaeoglobus fulgidus. Journal of Biomolecular Nmr. 38: 183. PMID 17206469 DOI: 10.1007/s10858-006-9114-x  1
2007 Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, ... ... Arrowsmith C, et al. Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Molecular and Biochemical Parasitology. 151: 100-10. PMID 17125854 DOI: 10.1016/J.Molbiopara.2006.10.011  1
2007 Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA. NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Proteins. 66: 266-71. PMID 17096419 DOI: 10.1002/Prot.21199  1
2007 Ignatchenko A, Gutmanas A, Lemak A, Yee A, Karra M, Srisailam S, Arrowsmith C. Solution Structure of protein RPA3401, Northeast Structural Genomics Consortium Target RpT7, Ontario Center for Structural Proteomics Target RP3384 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Jtv/Pdb  1
2007 Singarapu KK, Wu Y, Yee A, Semesi A, Arrowsmith C, Szyperski T. NMR Structure of 50S Ribosomal Protein L14e from Sulfolobus Solfataricus: Northeast Structural Genomics Consortium Target SSR105 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Joy/Pdb  1
2007 Ramelot T, Cort J, Yee A, Semesi A, Johnathan L, Arrowsmith C, Kennedy M. NMR structure of E.coli YfgJ protein modelled with two Zn+2 bound. Northeast Structural Genomics Consortium Target ER317. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Jne/Pdb  1
2007 Higman VA, Leidert M, Bray J, Elkins J, Soundararajan M, Doyle DA, Gileadi C, Phillips C, Schoch G, Yang X, Brockmann C, Schmieder P, Diehl A, Sundstrom M, Arrowsmith C, et al. Solution structure of the RGS domain of human RGS14 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Jm5/Pdb  1
2007 Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Structural and chemical profiling of the human cytosolic sulfotransferases Plos Biology. 5: 1063-1078. DOI: 10.1371/Journal.Pbio.0050097  1
2007 Fedorov O, Higman V, Leidert M, Elkins J, Soundararajan M, Doyle D, Schmieder P, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, Diehl A, Oschkinat H, Ball L. Backbone and Side Chains Assignments of RGS10 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr7272  1
2007 Doherty R, Dhe-Paganon S, Fares C, Lemak A, Butler C, Srisailam S, Karra M, Yee A, Edwards A, Weigelt J, Arrowsmith C. Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium Target hr5627. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15576  1
2007 Cort J, Yee A, Arrowsmith C, Kennedy M. Chemical Shift Assignments for protein NE0084 from Nitrosomonas europea: Northeast Structural Genomics Target NeT6 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15347  1
2007 Lemak A, Srisailam S, Yee A, Karra M, Lukin J, Arrowsmith C. Complete Assignment of a hypothetical portein RP4601 (NESG ID: RpT2)from Rhodopseudomonas palustris. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15085  1
2007 Tyler JJ, Leng MJ, Arrowsmith C. Seasonality and the isotope hydrology of Lochnagar, a Scottish mountain lake: Implications for palaeoclimate research Holocene. 17: 717-727. DOI: 10.1177/0959683607080513  1
2007 Black J, Arrowsmith C, Black M, Cartwright W. Comparison of techniques for visualising fire behaviour Transactions in Gis. 11: 621-635. DOI: 10.1111/j.1467-9671.2007.01063.x  1
2007 LIU Gj, FU Ej, WANG Yj, ZHANG Kf, HAN Bp, ARROWSMITH C. A Framework of Environmental Modelling and Information Sharing for Urban Air Pollution Control and Management Journal of China University of Mining and Technology. 17: 172-178. DOI: 10.1016/S1006-1266(07)60066-2  1
2007 Thomas ER, Wolff EW, Mulvaney R, Steffensen JP, Johnsen SJ, Arrowsmith C, White JWC, Vaughn B, Popp T. The 8.2 ka event from Greenland ice cores Quaternary Science Reviews. 26: 70-81. DOI: 10.1016/J.Quascirev.2006.07.017  1
2007 Mackie EAV, Lloyd JM, Leng MJ, Bentley MJ, Arrowsmith C. Assessment of δ13C and C/N ratios in bulk organic matter as palaeosalinity indicators in Holocene and Lateglacial isolation basin sediments, northwest Scotland Journal of Quaternary Science. 22: 579-591. DOI: 10.1002/jqs.1081  1
2007 Keatings K, Tassie GJ, Flower RJ, Hassan FA, Hamdan MAR, Hughes M, Arrowsmith C. An examination of groundwater within the Hawara Pyramid, Egypt Geoarchaeology. 22: 533-554. DOI: 10.1002/gea.20171  1
2006 Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, et al. Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proceedings of the National Academy of Sciences of the United States of America. 103: 15835-40. PMID 17035505 DOI: 10.1073/Pnas.0605224103  1
2006 Jung J, Yeo IY, Hong E, Yee A, Arrowsmith CH, Lee W. Solution structure of TA0895, a MoaD homologue from Thermoplasma acidophilum. Proteins. 65: 1055-7. PMID 17019685 DOI: 10.1002/prot.21171  1
2006 Kuznetsova E, Proudfoot M, Gonzalez CF, Brown G, Omelchenko MV, Borozan I, Carmel L, Wolf YI, Mori H, Savchenko AV, Arrowsmith CH, Koonin EV, Edwards AM, Yakunin AF. Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. The Journal of Biological Chemistry. 281: 36149-61. PMID 16990279 DOI: 10.1074/jbc.M605449200  1
2006 Yee A, Gutmanas A, Arrowsmith CH. Solution NMR in structural genomics. Current Opinion in Structural Biology. 16: 611-7. PMID 16942869 DOI: 10.1016/j.sbi.2006.08.002  1
2006 Revington M, Semesi A, Yee A, Arrowsmith CH, Shaw GS. The solution structure of the protein ydhA from Escherichia coli. Journal of Biomolecular Nmr. 35: 295-300. PMID 16937244 DOI: 10.1007/S10858-006-9032-Y  1
2006 Lin YC, Liu G, Shen Y, Bertonati C, Yee A, Honig B, Arrowsmith CH, Szyperski T. NMR structure of protein PA2021 from Pseudomonas aeruginosa. Proteins. 65: 767-70. PMID 16927296 DOI: 10.1002/Prot.21098  1
2006 Julien O, Gignac I, Hutton A, Yee A, Arrowsmith CH, Gagné SM. MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats. Journal of Biomolecular Nmr. 35: 149-54. PMID 16819590 DOI: 10.1007/s10858-006-0029-3  1
2006 Jeon BY, Jung J, Kim DW, Yee A, Arrowsmith CH, Lee W. Solution structure of TA1092, a ribosomal protein S24e from Thermoplasma acidophilum. Proteins. 64: 1095-7. PMID 16786596 DOI: 10.1002/prot.21045  1
2006 Srisailam S, Lukin JA, Yee A, Semesi A, Arrowsmith CH. Solution structure of acyl carrier protein from Nitrosomonas europaea. Proteins. 64: 800-3. PMID 16741959 DOI: 10.1002/prot.21016  1
2006 Srisailam S, Lukin JA, Lemak A, Yee A, Arrowsmith CH. Sequence specific resonance assignment of a hypothetical protein PA0128 from Pseudomonas aeruginosa. Journal of Biomolecular Nmr. 36: 27. PMID 16703420 DOI: 10.1007/s10858-006-0011-0  1
2006 Monleón D, Nunes S, Esteve V, Yee A, Arrowsmith C, Celda B. Resonance assignments for the hypothetical protein TA0938 from Thermoplasma acidophilum. Journal of Biomolecular Nmr. 36: 36. PMID 16703419 DOI: 10.1007/S10858-006-5968-1  1
2006 Kaustov L, Yi GS, Ayed A, Bochkareva E, Bochkarev A, Arrowsmith CH. p53 transcriptional activation domain: A molecular chameleon? Cell Cycle. 5: 489-494. PMID 16481746  1
2006 Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nature Structural & Molecular Biology. 13: 285-91. PMID 16474402 DOI: 10.1038/Nsmb1067  1
2006 Kim B, Jung J, Hong E, Yee A, Arrowsmith CH, Lee W. NMR structure of the conserved novel-fold protein TA0743 from Thermoplasma acidophilum. Proteins. 62: 819-21. PMID 16374782 DOI: 10.1002/prot.20832  1
2006 Eletsky A, Atreya H, Liu G, Sukumaran D, Garcia M, Yee A, Arrowsmith C, Szyperski T. 1H, 13C, and 15N Chemical Shift Assignments for Pseudomonas aeruginosa Hypothetical Protein RPA1041: Northeast Structural Genomics Consortium target Pat90 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr7191  1
2006 Higman V, Leidert M, Elkins J, Soundararajan M, Brockmann C, Schmieder P, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, Diehl A, Oschkinat H, Ball L. NMR Assignment of human RGS18 (regulator of G-protein signalling) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr7106  1
2005 Yee AA, Savchenko A, Ignachenko A, Lukin J, Xu X, Skarina T, Evdokimova E, Liu CS, Semesi A, Guido V, Edwards AM, Arrowsmith CH. NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins. Journal of the American Chemical Society. 127: 16512-7. PMID 16305238 DOI: 10.1021/ja053565+  1
2005 Bochkareva E, Kaustov L, Ayed A, Yi GS, Lu Y, Pineda-Lucena A, Liao JC, Okorokov AL, Milner J, Arrowsmith CH, Bochkarev A. Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A. Proceedings of the National Academy of Sciences of the United States of America. 102: 15412-7. PMID 16234232 DOI: 10.1073/pnas.0504614102  1
2005 Amegbey G, Stothard P, Kuznetsova E, Yee A, Arrowsmith CH, Wishart DS. Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum. Journal of Biomolecular Nmr. 33: 51-6. PMID 16222557 DOI: 10.1007/S10858-005-1275-5  1
2005 Luan T, Jaravine V, Yee A, Arrowsmith CH, Orekhov VY. Optimization of resolution and sensitivity of 4D NOESY using multi-dimensional decomposition. Journal of Biomolecular Nmr. 33: 1-14. PMID 16222553 DOI: 10.1007/s10858-005-1363-6  1
2005 Jung JW, Yee A, Wu B, Arrowsmith CH, Lee W. Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae. Journal of Biochemistry and Molecular Biology. 38: 550-4. PMID 16202234  1
2005 Grishaev A, Steren CA, Wu B, Pineda-Lucena A, Arrowsmith C, Llinás M. ABACUS, a direct method for protein NMR structure computation via assembly of fragments. Proteins. 61: 36-43. PMID 16080153 DOI: 10.1002/Prot.20457  1
2005 Liu G, Shen Y, Atreya HS, Parish D, Shao Y, Sukumaran DK, Xiao R, Yee A, Lemak A, Bhattacharya A, Acton TA, Arrowsmith CH, Montelione GT, Szyperski T. NMR data collection and analysis protocol for high-throughput protein structure determination. Proceedings of the National Academy of Sciences of the United States of America. 102: 10487-92. PMID 16027363 DOI: 10.1073/Pnas.0504338102  1
2005 Pineda-Lucena A, Ho CS, Mao DY, Sheng Y, Laister RC, Muhandiram R, Lu Y, Seet BT, Katz S, Szyperski T, Penn LZ, Arrowsmith CH. A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. Journal of Molecular Biology. 351: 182-94. PMID 15992821 DOI: 10.1016/J.Jmb.2005.05.046  1
2005 Penhoat CH, Li Z, Atreya HS, Kim S, Yee A, Xiao R, Murray D, Arrowsmith CH, Szyperski T. NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure. Journal of Structural and Functional Genomics. 6: 51-62. PMID 15965736 DOI: 10.1007/S10969-005-5277-Z  1
2005 Dobrovetsky E, Lu ML, Andorn-Broza R, Khutoreskaya G, Bray JE, Savchenko A, Arrowsmith CH, Edwards AM, Koth CM. High-throughput production of prokaryotic membrane proteins. Journal of Structural and Functional Genomics. 6: 33-50. PMID 15909233 DOI: 10.1007/S10969-005-1363-5  1
2005 Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T, Zhang RG, Liao J, Lee W, Edwards AM, Arrowsmith CH, Frappier L. Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Molecular Cell. 18: 25-36. PMID 15808506 DOI: 10.1016/J.Molcel.2005.02.029  1
2005 Huang YJ, Moseley HN, Baran MC, Arrowsmith C, Powers R, Tejero R, Szyperski T, Montelione GT. An integrated platform for automated analysis of protein NMR structures. Methods in Enzymology. 394: 111-41. PMID 15808219 DOI: 10.1016/S0076-6879(05)94005-6  1
2005 Savchenko A, Krogan N, Cort JR, Evdokimova E, Lew JM, Yee AA, Sánchez-Pulido L, Andrade MA, Bochkarev A, Watson JD, Kennedy MA, Greenblatt J, Hughes T, Arrowsmith CH, Rommens JM, et al. The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. The Journal of Biological Chemistry. 280: 19213-20. PMID 15701634 DOI: 10.1074/Jbc.M414421200  1
2005 Gaspar JA, Liu C, Vassall KA, Meglei G, Stephen R, Stathopulos PB, Pineda-Lucena A, Wu B, Yee A, Arrowsmith CH, Meiering EM. A novel member of the YchN-like fold: solution structure of the hypothetical protein Tm0979 from Thermotoga maritima. Protein Science : a Publication of the Protein Society. 14: 216-23. PMID 15608123 DOI: 10.1110/ps.041068605  1
2005 Mark WY, Liao JC, Lu Y, Ayed A, Laister R, Szymczyna B, Chakrabartty A, Arrowsmith CH. Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions? Journal of Molecular Biology. 345: 275-87. PMID 15571721 DOI: 10.1016/J.Jmb.2004.10.045  1
2005 Ramelot T, Yee A, Arrowsmith C, Kennedy M. 1H, 13C, and 15N Chemical Shift Assignments for Psuedomonas Aeruginosa protein PA4608 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr6514  1
2005 Amegbey G, Zhan C, Yee A, Arrowsmith C, Wishart D. Nmr Assignment Of Mth0776 From Methanobacterium Thermoautotrophicum Strain H Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr6272  1
2005 Ramelot T, Cort J, Yee A, Guido V, Lukin J, Arrowsmith C, Kennedy M. NMR structure of the E.coli protein NirD, Northeast Structural Genomics target ET100 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15139  1
2005 Stephenson MH, Leng MJ, Vane CH, Osterloff PL, Arrowsmith C. Investigating the record of Permian climate change from argillaceous sedimentary rocks, Oman Journal of the Geological Society. 162: 641-651. DOI: 10.1144/0016-764904-096  1
2005 Mackie EAV, Leng MJ, Lloyd JM, Arrowsmith C. Bulk organic δ13 C and C/N ratios as palaeosalinity indicators within a Scottish isolation basin Journal of Quaternary Science. 20: 303-312. DOI: 10.1002/jqs.919  1
2005 Xia J, Arrowsmith C. Managing scale issues in spatio-temporal movement of tourists modelling Modsim05 - International Congress On Modelling and Simulation: Advances and Applications For Management and Decision Making, Proceedings. 162-169.  1
2004 Amegbey G, Chang Z, Stothard P, Yee A, Arrowsmith C, Wishart DS. Complete 1H, 13C and 15N NMR assignments of MTH0776 from Methanobacterium thermoautotrophicum. Journal of Biomolecular Nmr. 30: 459-60. PMID 15630567 DOI: 10.1007/S10858-004-4341-5  1
2004 Yakunin AF, Proudfoot M, Kuznetsova E, Savchenko A, Brown G, Arrowsmith CH, Edwards AM. The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2′,3′-cyclic phosphodiesterase, 2′-nucleotidase, and phosphatase activities Journal of Biological Chemistry. 279: 36819-36827. PMID 15210699 DOI: 10.1074/jbc.M405120200  1
2004 Blanco FJ, Yee A, Campos-Olivas R, Ortiz AR, Devos D, Valencia A, Arrowsmith CH, Rico M. Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold. Protein Science : a Publication of the Protein Society. 13: 1458-65. PMID 15152082 DOI: 10.1110/Ps.04620504  1
2004 Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W. Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum. Protein Science : a Publication of the Protein Society. 13: 1148-54. PMID 15044740 DOI: 10.1110/ps.03472104  1
2004 Saridakis V, Yakunin A, Xu X, Anandakumar P, Pennycooke M, Gu J, Cheung F, Lew JM, Sanishvili R, Joachimiak A, Arrowsmith CH, Christendat D, Edwards AM. The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase. The Journal of Biological Chemistry. 279: 23646-53. PMID 15044458 DOI: 10.1074/Jbc.M401395200  1
2004 Yakunin AF, Yee AA, Savchenko A, Edwards AM, Arrowsmith CH. Structural proteomics: a tool for genome annotation. Current Opinion in Chemical Biology. 8: 42-8. PMID 15036155 DOI: 10.1016/j.cbpa.2003.12.003  1
2004 Gutiérrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K. Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation. Protein Science : a Publication of the Protein Society. 13: 659-67. PMID 14978306 DOI: 10.1110/Ps.03506604  1
2004 Bhattacharya S, Arunkumar AI, Sullivan SL, Botuyan MV, Arrowsmith CH, Chazin WJ. 1H, 13C and 15N assignments of single-stranded DNA binding domains from the 70 kDa subunit of human replication protein A. Journal of Biomolecular Nmr. 28: 195-6. PMID 14755166 DOI: 10.1023/B:Jnmr.0000013818.02364.3A  1
2004 Monleón D, Yee A, Liu CS, Arrowsmith C, Celda B. Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum. Journal of Biomolecular Nmr. 28: 81-4. PMID 14739641 DOI: 10.1023/B:Jnmr.0000012862.33577.74  1
2004 Savchenko A, Skarina T, Evdokimova E, Watson JD, Laskowski R, Arrowsmith CH, Edwards AM, Joachimiak A, Zhang RG. X-ray crystal structure of CutA from Thermotoga maritima at 1.4 A resolution. Proteins. 54: 162-5. PMID 14705033 DOI: 10.1002/Prot.10585  1
2004 Kim Y, Yakunin AF, Kuznetsova E, Xu X, Pennycooke M, Gu J, Cheung F, Proudfoot M, Arrowsmith CH, Joachimiak A, Edwards AM, Christendat D. Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum. The Journal of Biological Chemistry. 279: 517-26. PMID 14555659 DOI: 10.1074/Jbc.M306054200  1
2004 Wu B, Yee A, Ramelot T, Cort J, Kennedy M, Arrowsmith C. Northeast Structural Genomics Consortium Target TT802 Ontario Center for Structural Proteomics Target Mth0803 assignment of ribosomal protein S17E Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr6028  1
2004 Chhetri P, Arrowsmith C, Jackson M. Determining hiking experiences in nature-based tourist destinations Tourism Management. 25: 31-43. DOI: 10.1016/S0261-5177(03)00057-8  1
2003 Wu B, Yee A, Pineda-Lucena A, Semesi A, Ramelot TA, Cort JR, Jung JW, Edwards A, Lee W, Kennedy M, Arrowsmith CH. Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum. Protein Science : a Publication of the Protein Society. 12: 2831-7. PMID 14627743 DOI: 10.1110/Ps.03358203  1
2003 Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, McPherson P, Shehabeldin A, Laister R, Arrowsmith C, Kanaar R, et al. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. The Embo Journal. 22: 6137-47. PMID 14609959 DOI: 10.1093/Emboj/Cdg580  1
2003 Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L. Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. The Journal of Biological Chemistry. 278: 47753-61. PMID 14506283 DOI: 10.1074/Jbc.M307200200  1
2003 Xia Y, Yee A, Arrowsmith CH, Gao X. 1H(C) and 1H(N) total NOE correlations in a single 3D NMR experiment. 15N and 13C time-sharing in t1 and t2 dimensions for simultaneous data acquisition. Journal of Biomolecular Nmr. 27: 193-203. PMID 12975580 DOI: 10.1023/A:1025407905478  1
2003 Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA. Solution structure of the yeast ubiquitin-like modifier protein Hub1. Journal of Structural and Functional Genomics. 4: 25-30. PMID 12943364 DOI: 10.1023/A:1024674220425  1
2003 Maxwell KL, Bona D, Liu C, Arrowsmith CH, Edwards AM. Refolding out of guanidine hydrochloride is an effective approach for high-throughput structural studies of small proteins. Protein Science : a Publication of the Protein Society. 12: 2073-80. PMID 12931005 DOI: 10.1110/ps.0393503  1
2003 Tao X, Khayat R, Christendat D, Savchenko A, Xu X, Goldsmith-Fischman S, Honig B, Edwards A, Arrowsmith CH, Tong L. Crystal structures of MTH1187 and its yeast ortholog YBL001c. Proteins. 52: 478-80. PMID 12866058 DOI: 10.1002/Prot.10443  1
2003 Daughdrill GW, Buchko GW, Botuyan MV, Arrowsmith C, Wold MS, Kennedy MA, Lowry DF. Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A. Nucleic Acids Research. 31: 4176-83. PMID 12853635 DOI: 10.1093/Nar/Gkg451  1
2003 Kimber MS, Vallee F, Houston S, Necakov A, Skarina T, Evdokimova E, Beasley S, Christendat D, Savchenko A, Arrowsmith CH, Vedadi M, Gerstein M, Edwards AM. Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens. Proteins. 51: 562-8. PMID 12784215 DOI: 10.1002/Prot.10340  1
2003 Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM. Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. The Journal of Biological Chemistry. 278: 26039-45. PMID 12732651 DOI: 10.1074/Jbc.M303867200  1
2003 Pineda-Lucena A, Liao JC, Cort JR, Yee A, Kennedy MA, Edwards AM, Arrowsmith CH. A novel member of the split betaalphabeta fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae. Protein Science : a Publication of the Protein Society. 12: 1136-40. PMID 12717036 DOI: 10.1110/Ps.0240903  1
2003 Yee A, Pardee K, Christendat D, Savchenko A, Edwards AM, Arrowsmith CH. Structural proteomics: toward high-throughput structural biology as a tool in functional genomics. Accounts of Chemical Research. 36: 183-9. PMID 12641475 DOI: 10.1021/Ar010126G  1
2003 Gerstein M, Edwards A, Arrowsmith CH, Montelione GT. Structural genomics: Current progress [3] Science. 299: 1663. PMID 12637721 DOI: 10.1126/Science.299.5613.1663A  1
2003 Szymczyna BR, Bowman J, McCracken S, Pineda-Lucena A, Lu Y, Cox B, Lambermon M, Graveley BR, Arrowsmith CH, Blencowe BJ. Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. Genes & Development. 17: 461-75. PMID 12600940 DOI: 10.1101/Gad.1060403  1
2003 Zhang Rg, Andersson CE, Savchenko A, Skarina T, Evdokimova E, Beasley S, Arrowsmith CH, Edwards AM, Joachimiak A, Mowbray SL. Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle. Structure (London, England : 1993). 11: 31-42. PMID 12517338 DOI: 10.1016/S0969-2126(02)00933-4  1
2003 Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L. Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. The Journal of Biological Chemistry. 278: 8804-8. PMID 12496312 DOI: 10.1074/Jbc.M211892200  1
2003 Zarembinski TI, Kim Y, Peterson K, Christendat D, Dharamsi A, Arrowsmith CH, Edwards AM, Joachimiak A. Deep trefoil knot implicated in RNA binding found in an archaebacterial protein. Proteins. 50: 177-83. PMID 12486711 DOI: 10.1002/Prot.10311  1
2003 Blanco F, Campos-Olivas R, Yee A, Arrowsmith C, Rico M. 1H, 13C, and 15N assignment of mth677 protein from Methanobacterium Thermoautotrophicum Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5704  1
2003 Cort J, Yee A, Arrowsmith C, Kennedy M. Solution Structure of the Product of the S. Cerevisiae YHR087W Gene, Northeast Structural Genomics Consortium target YTYst425 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5695  1
2003 Watson D, Goudey R, Arrowsmith C. Mapping the spatial extent of environmental health: An approach using stream turbidity Advances in Ecological Sciences. 18: 39-48.  1
2002 Kennedy MA, Montelione GT, Arrowsmith CH, Markley JL. Role for NMR in structural genomics. Journal of Structural and Functional Genomics. 2: 155-69. PMID 12836706 DOI: 10.1023/A:1021261026670  1
2002 Xia Y, Arrowsmith CH, Szyperski T. Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment. Journal of Biomolecular Nmr. 24: 41-50. PMID 12449417 DOI: 10.1023/A:1020605618150  1
2002 Ramelot TA, Cort JR, Yee AA, Liu F, Goshe MB, Edwards AM, Smith RD, Arrowsmith CH, Dever TE, Kennedy MA. Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha. Journal of Molecular Biology. 322: 943-54. PMID 12367520 DOI: 10.1016/S0022-2836(02)00858-6  1
2002 Bhattacharya S, Botuyan MV, Hsu F, Shan X, Arunkumar AI, Arrowsmith CH, Edwards AM, Chazin WJ. Characterization of binding-induced changes in dynamics suggests a model for sequence-nonspecific binding of ssDNA by replication protein A. Protein Science : a Publication of the Protein Society. 11: 2316-25. PMID 12237454 DOI: 10.1110/Ps.0209202  1
2002 Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA. NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins. Proteins. 49: 289-93. PMID 12211008 DOI: 10.1002/Prot.10214  1
2002 Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L. Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase. Proteins. 49: 285-8. PMID 12211007 DOI: 10.1002/Prot.10209  1
2002 Kim Y, Skarina T, Beasley S, Laskowski R, Arrowsmith C, Joachimiak A, Edwards A, Savchenko A. Crystal structure of Escherichia coli EC1530, a glyoxylate induced protein YgbM. Proteins. 48: 427-30. PMID 12112708 DOI: 10.1002/Prot.10160  1
2002 Maxwell KL, Yee AA, Arrowsmith CH, Gold M, Davidson AR. The solution structure of the bacteriophage lambda head-tail joining protein, gpFII. Journal of Molecular Biology. 318: 1395-404. PMID 12083526 DOI: 10.1016/S0022-2836(02)00276-0  1
2002 Gutiérrez P, Coillet-Matillon S, Arrowsmith C, Gehring K. Zinc is required for structural stability of the C-terminus of archaeal translation initiation factor aIF2β Febs Letters. 517: 155-158. PMID 12062427 DOI: 10.1016/S0014-5793(02)02610-8  1
2002 Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM. The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum. Protein Science : a Publication of the Protein Society. 11: 1409-14. PMID 12021439 DOI: 10.1110/Ps.4720102  1
2002 Saridakis V, Christendat D, Thygesen A, Arrowsmith CH, Edwards AM, Pai EF. Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold. Proteins. 48: 141-3. PMID 12012346 DOI: 10.1002/Prot.10147  1
2002 Pineda-Lucena A, Liao J, Wu B, Yee A, Cort JR, Kennedy MA, Edwards AM, Arrowsmith CH. NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli. Proteins. 47: 572-4. PMID 12001238 DOI: 10.1002/Prot.10120  1
2002 Szymczyna BR, Pineda-Lucena A, Mills JL, Szyperski T, Arrowsmith CH. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. Journal of Biomolecular Nmr. 22: 299-300. PMID 11991360 DOI: 10.1023/A:1014904502424  1
2002 Bhattacharyya S, Habibi-Nazhad B, Amegbey G, Slupsky CM, Yee A, Arrowsmith C, Wishart DS. Identification of a novel archaebacterial thioredoxin: Determination of function through structure Biochemistry. 41: 4760-4770. PMID 11939770 DOI: 10.1021/Bi0115176  1
2002 Zhang RG, Kim Y, Skarina T, Beasley S, Laskowski R, Arrowsmith C, Edwards A, Joachimiak A, Savchenko A. Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family. The Journal of Biological Chemistry. 277: 19183-90. PMID 11877432 DOI: 10.1074/Jbc.M112171200  1
2002 Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, ... ... Arrowsmith CH, et al. An NMR approach to structural proteomics. Proceedings of the National Academy of Sciences of the United States of America. 99: 1825-30. PMID 11854485 DOI: 10.1073/Pnas.042684599  1
2002 Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, Joachimiak A, Pegg AE, Savchenko A. The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nature Structural Biology. 9: 27-31. PMID 11731804 DOI: 10.1038/Nsb737  1
2002 Wu B, Yee A, Arrowsmith C. Assignment for ribosomal protein S28E Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5620  1
2002 Ramelot T, Cort J, Yee A, Furong L, Goshe M, Edwards A, Smith R, Arrowsmith C, Dever T, Kennedy M. 1H, 15N, 13C NMR Assignments of M156R Protein from myxoma virus, NESG target OP2 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5077  1
2002 Noon PE, Leng MJ, Arrowsmith C, Edworthy MG, Strachan RJ. Seasonal observations of stable isotope variations in a valley catchment, Signy Island, South Orkney Islands Antarctic Science. 14: 333-342. DOI: 10.1017/S0954102002000159  1
2002 Arrowsmith C, Inbakaran R. Estimating environmental resiliency for the Grampians National Park, Victoria, Australia: A quantitative approach Tourism Management. 23: 295-309. DOI: 10.1016/S0261-5177(01)00088-7  1
2002 Arrowsmith C, Ntuwah W. Mapping potential for tourist segments Cartography. 31: 55-62.  1
2002 Chhetri P, Arrowsmith C. Developing a spatial model of probable hiking experiences through natural landscapes Cartography. 31: 87-102.  1
2002 Shaw D, Cartwright W, Arrowsmith C. Telematics: Identifying the new geographies of digital communication Cartography. 31: 73-86.  1
2002 Mulvaney R, Oerter H, Peel DA, Graf W, Arrowsmith C, Pasteur EC, Knight B, Littot GC, Miners WD. 1000 year ice-core records from Berkner Island, Antarctica Annals of Glaciology. 35: 45-51.  1
2001 Das K, Xiao R, Wahlberg E, Hsu F, Arrowsmith CH, Montelione GT, Arnold E. X-ray crystal structure of MTH938 from methanobacterium thermoautotrophicum at 2.2 Å resolution reveals a novel tertiary protein fold Proteins: Structure, Function and Genetics. 45: 486-488. PMID 11746696 DOI: 10.1002/Prot.1162  1
2001 Zhang RG, Skarina T, Katz JE, Beasley S, Khachatryan A, Vyas S, Arrowsmith CH, Clarke S, Edwards A, Joachimiak A, Savchenko A. Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. Structure (London, England : 1993). 9: 1095-106. PMID 11709173 DOI: 10.1016/S0969-2126(01)00675-X  1
2001 Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP. NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum [1] Journal of Biomolecular Nmr. 21: 63-66. PMID 11693569 DOI: 10.2210/Pdb1Iio/Pdb  1
2001 Botuyan MV, Mer G, Yi GS, Koth CM, Case DA, Edwards AM, Chazin WJ, Arrowsmith CH. Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide Journal of Molecular Biology. 312: 177-186. PMID 11545595 DOI: 10.1006/Jmbi.2001.4938  1
2001 Ayed A, Mulder FAA, Yi GS, Lu Y, Kay LE, Arrowsmith CH. Latent and active p53 are identical in conformation Nature Structural Biology. 8: 756-760. PMID 11524676 DOI: 10.1038/Nsb0901-756  1
2001 Daughdrill GW, Ackerman J, Isern NG, Botuyan MV, Arrowsmith C, Wold MS, Lowry DF. The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding. Nucleic Acids Research. 29: 3270-6. PMID 11470885 DOI: 10.1093/Nar/29.15.3270  1
2001 Bertone P, Kluger Y, Lan N, Zheng D, Christendat D, Yee A, Edwards AM, Arrowsmith CH, Montelione GT, Gerstein M. SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics. Nucleic Acids Research. 29: 2884-98. PMID 11433035 DOI: 10.1093/Nar/29.13.2884  1
2001 Elston DA, Moss R, Boulinier T, Arrowsmith C, Lambin X. Analysis of aggregation, a worked example: Numbers of ticks on red grouse chicks Parasitology. 122: 563-569. PMID 11393830 DOI: 10.1017/S0031182001007740  1
2001 Maxwell KL, Yee AA, Booth V, Arrowsmith CH, Gold M, Davidson AR. The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold. Journal of Molecular Biology. 308: 9-14. PMID 11302702 DOI: 10.1006/Jmbi.2001.4582  1
2001 Pineda-Lucena A, Arrowsmith CH. 1H, 13C and 15N resonance assignments and secondary structure of the c-Myc binding domain (MBD) and the SH3 domain of the tumor suppressor Bin1 [3] Journal of Biomolecular Nmr. 19: 191-192. PMID 11256816 DOI: 10.1023/A:1008387817677  1
2001 Davison TS, Nie X, Ma W, Lin Y, Kay C, Benchimol S, Arrowsmith CH. Structure and functionality of a designed p53 dimer. Journal of Molecular Biology. 307: 605-17. PMID 11254385 DOI: 10.1006/Jmbi.2001.4450  1
2001 Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee G, Bhattacharyya S, Gutierrez P, Denisov A, Lee C, Cort J, Kozlov G, Liao J, ... ... Arrowsmith C, et al. Solution structure of hemolysin expression modulating protein Hha Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5166  1
2000 Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA. NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum. Journal of Structural and Functional Genomics. 1: 15-25. PMID 12836677 DOI: 10.1023/A:1011348803324  1
2000 Edwards AM, Arrowsmith CH, Christendat D, Dharamsi A, Friesen JD, Greenblatt JF, Vedadi M. Protein production: feeding the crystallographers and NMR spectroscopists. Nature Structural Biology. 7: 970-2. PMID 11104003 DOI: 10.1038/80751  1
2000 Mulder FAA, Ayed A, Yang D, Arrowsmith CH, Kay LE. Assignment of 1H(N), 15N, 13C(α), 13CO and 13C(β) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy Journal of Biomolecular Nmr. 18: 173-176. PMID 11101222 DOI: 10.1023/A:1008317825976  1
2000 Christendat D, Yee A, Dharamsi A, Kluger Y, Gerstein M, Arrowsmith CH, Edwards AM. Structural proteomics: Prospects for high throughput sample preparation Progress in Biophysics and Molecular Biology. 73: 339-345. PMID 11063779 DOI: 10.1016/S0079-6107(00)00010-9  1
2000 Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort JR, Booth V, Mackereth CD, Saridakis V, Ekiel I, Kozlov G, Maxwell KL, Wu N, McIntosh LP, Gehring K, ... ... Arrowsmith CH, et al. Structural proteomics of an archaeon. Nature Structural Biology. 7: 903-9. PMID 11017201 DOI: 10.1038/82823  1
2000 Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA. Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum Journal of Molecular Biology. 302: 189-203. PMID 10964569 DOI: 10.1006/Jmbi.2000.4052  1
2000 Noolandi J, Davison TS, Volkel AR, Nie X, Kay C, Arrowsmith CH. A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53. Proceedings of the National Academy of Sciences of the United States of America. 97: 9955-60. PMID 10944184 DOI: 10.1073/Pnas.160075697  1
2000 Szymczyna BR, Arrowsmith CH. DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition. The Journal of Biological Chemistry. 275: 28363-70. PMID 10867009 DOI: 10.1074/Jbc.M004294200  1
2000 Mackereth CD, Arrowsmith CH, Edwards AM, McIntosh LP. Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum. Proceedings of the National Academy of Sciences of the United States of America. 97: 6316-21. PMID 10841539 DOI: 10.1073/Pnas.97.12.6316  1
2000 Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH. Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum Proceedings of the National Academy of Sciences of the United States of America. 97: 6311-6315. PMID 10841538 DOI: 10.1073/Pnas.97.12.6311  1
2000 Christendat D, Saridakis V, Dharamsi A, Bochkarev A, Pai EF, Arrowsmith CH, Edwards AM. Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP Journal of Biological Chemistry. 275: 24608-24612. PMID 10827167 DOI: 10.1074/Jbc.C000238200  1
2000 Booth V, Koth CM, Edwards AM, Arrowsmith CH. Structure of a conserved domain common to the transcription factors TFIIS, Elongin A, and CRSP70 Journal of Biological Chemistry. 275: 31266-31268. PMID 10811649 DOI: 10.1074/Jbc.M002595200  1
2000 Li PX, Wong J, Ayed A, Ngo D, Brade AM, Arrowsmith C, Austin RC, Klamut HJ. Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. The Journal of Biological Chemistry. 275: 20127-35. PMID 10777512 DOI: 10.1074/Jbc.M909580199  1
2000 Koth CM, Botuyan MV, Moreland RJ, Jansma DB, Conaway JW, Conaway RC, Chazin WJ, Friesen JD, Arrowsmith CH, Edwards AM. Elongin from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 275: 11174-80. PMID 10753924 DOI: 10.1074/Jbc.275.15.11174  1
2000 Edwards AM, Arrowsmith CH, Des Pallieres BD. Proteomics: New tools for a new era - Bridging the gap between genomics and drug discovery Modern Drug Discovery. 3: 35-44.  1
1999 Arrowsmith CH. Structure and function in the p53 family Cell Death and Differentiation. 6: 1169-1173. PMID 10637432  1
1999 Chi SW, Ayed A, Arrowsmith CH. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. The Embo Journal. 18: 4438-45. PMID 10449409 DOI: 10.1093/emboj/18.16.4438  1
1999 Botuyan MV, Koth CM, Mer G, Chakrabartty A, Conaway JW, Conaway RC, Edwards AM, Arrowsmith CH, Chazin WJ. Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C Proceedings of the National Academy of Sciences of the United States of America. 96: 9033-9038. PMID 10430890 DOI: 10.1073/Pnas.96.16.9033  1
1999 Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. The Journal of Biological Chemistry. 274: 18709-14. PMID 10373484 DOI: 10.1074/Jbc.274.26.18709  1
1998 Bagby S, Arrowsmith CH, Ikura M. New perceptions of transcription factor properties from NMR Biochemistry and Cell Biology. 76: 368-378. PMID 9923706  1
1998 Awrey DE, Shimasaki N, Koth C, Weilbaecher R, Olmsted V, Kazanis S, Shan X, Arellano J, Arrowsmith CH, Kane CM, Edwards AM. Yeast transcript elongation factor (TFIIS), structure and function. II: RNA polymerase binding, transcript cleavage, and read-through. The Journal of Biological Chemistry. 273: 22595-605. PMID 9712888 DOI: 10.1074/Jbc.273.35.22595  1
1998 Olmsted VK, Awrey DE, Koth C, Shan X, Morin PE, Kazanis S, Edwards AM, Arrowsmith CH. Yeast transcript elongation factor (TFIIS), structure and function. I: NMR structural analysis of the minimal transcriptionally active region. The Journal of Biological Chemistry. 273: 22589-94. PMID 9712887 DOI: 10.1074/Jbc.273.35.22589  1
1998 Davison TS, Yin P, Nie E, Kay C, Arrowsmith CH. Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome. Oncogene. 17: 651-6. PMID 9704931 DOI: 10.1038/Sj.Onc.1202062  1
1998 Shan X, Gardner KH, Muhandiram DR, Kay LE, Arrowsmith CH. Subunit-specific backbone NMR assignments of a 64 kDa trp repressor/DNA complex: a role for N-terminal residues in tandem binding. Journal of Biomolecular Nmr. 11: 307-18. PMID 9691278 DOI: 10.1023/A:1008257803130  1
1998 Petra G, Yee AA, Arrowsmith CH, Macgregor RB. Quantitative hydroxyl radical footprinting reveals cooperative interactions between DNA-binding subdomains of PU.1 and IRF4 Biochemistry. 37: 9802-9811. PMID 9657694 DOI: 10.1021/Bi9731448  1
1998 Potier N, Donald LJ, Chernushevich I, Ayed A, Ens W, Arrowsmith CH, Standing KG, Duckworth HW. Study of a noncovalent trp repressor: DNA operator complex by electrospray ionization time-of-flight mass spectrometry. Protein Science : a Publication of the Protein Society. 7: 1388-95. PMID 9655343 DOI: 10.1002/Pro.5560070615  1
1998 Yee AA, Yin P, Siderovski DP, Mak TW, Litchfield DW, Arrowsmith CH. Cooperative interaction between the DNA-binding domains of PU.1 and IRF4 Journal of Molecular Biology. 279: 1075-1083. PMID 9642085 DOI: 10.1006/Jmbi.1998.1838  1
1998 Gross P, Arrowsmith CH, Macgregor RB. Hydroxyl radical footprinting of DNA complexes of the ets domain of PU.1 and its comparison to the crystal structure Biochemistry. 37: 5129-5135. PMID 9548743 DOI: 10.1021/Bi972591K  1
1998 Arrowsmith C, Wilson M. Telecom tectonics using geographic information systems Cartography. 27: 1-8.  1
1997 Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. The Embo Journal. 16: 6018-33. PMID 9312059 DOI: 10.1093/Emboj/16.19.6018  1
1997 Moseley HN, Lee W, Arrowsmith CH, Krishna NR. Quantitative determination of conformational, dynamic, and kinetic parameters of a ligand-protein/DNA complex from a complete relaxation and conformational exchange matrix analysis of intermolecular transferred NOESY. Biochemistry. 36: 5293-9. PMID 9154911 DOI: 10.1021/bi970242k  1
1996 Morin PE, Awrey DE, Edwards AM, Arrowsmith CH. Elongation factor TFIIS contains three structural domains: Solution structure of domain II Proceedings of the National Academy of Sciences of the United States of America. 93: 10604-10608. PMID 8855225 DOI: 10.1073/pnas.93.20.10604  1
1996 Arrowsmith CH, Morin P. New insights into p53 function from structural studies Oncogene. 12: 1379-1385. PMID 8622853  1
1996 Shan X, Gardner KH, Muhandiram DR, Rao NS, Arrowsmith CH, Kay LE. Assignment of 15N, 13C(α), 13C(β), and HN resonances in an 15N,13C,2H labeled 64 kDa trp repressor-operator complex using triple-resonance NMR spectroscopy and 2H-decoupling Journal of the American Chemical Society. 118: 6570-6579. DOI: 10.1021/Ja960627A  1
1995 Yin Y, Zhang F, Ling V, Arrowsmith CH. Structural analysis and comparison of the C-terminal transport signal domains of hemolysin A and leukotoxin A. Febs Letters. 366: 1-5. PMID 7789505 DOI: 10.1016/0014-5793(95)00454-H  1
1995 Johnson CR, Morin PE, Arrowsmith CH, Freire E. Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor Biochemistry. 34: 5309-5316. PMID 7727392 DOI: 10.1021/Bi00016A002  1
1995 Arrowsmith CH, Lee W, Revington M, Yamazaki T, Kay LE. Toward the solution structure of large (>30 kDa) proteins and macromolecular complexes Techniques in Protein Chemistry. 6: 503-510. DOI: 10.1016/S1080-8914(06)80061-X  1
1994 Zhang H, Zhao D, Revington M, Lee W, Jia X, Arrowsmith C, Jardetzky O. The solution structures of the trp repressor-operator DNA complex. Journal of Molecular Biology. 238: 592-614. PMID 8176748 DOI: 10.1006/Jmbi.1994.1317  1
1994 Lee W, Revington MJ, Arrowsmith C, Kay LE. A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes Febs Letters. 350: 87-90. PMID 8062930 DOI: 10.1016/0014-5793(94)00740-3  1
1994 Lee W, Harvey TS, Yin Y, Yau P, Litchfield D, Arrowsmith CH. Solution structure of the tetrameric minimum transforming domain of p53 Nature Structural Biology. 1: 877-890. PMID 7773777 DOI: 10.1038/Nsb1294-877  1
1994 Yamazaki T, Lee W, Revington M, Mattiello DL, Dahlquist FW, Arrowsmith CH, Kay LE. An HNCA pulse scheme for the backbone assignment of 15N,13C,2H-labeled proteins: Application to a 37-kDa Trp repressor-DNA complex Journal of the American Chemical Society. 116: 6464-6465. DOI: 10.1021/Ja00093A069  1
1994 Arrowsmith CH, Guo HX, Kresge AJ. Hydrogen isotope fractionation factors for benzylamine and benzylammonium ion. Comparison of fractionation factors for neutral and positively-charged nitrogen-hydrogen bonds Journal of the American Chemical Society. 116: 8890-8894.  1
1994 Yamazaki T, Lee W, Arrowsmith CH, Muhandiram DR, Kay LE. A suite of triple resonance NMR experiments for the backbone assignment of 15N, 13C, 2H labeled proteins with high sensitivity Journal of the American Chemical Society. 116: 11655-11666.  1
1993 Zhao D, Arrowsmith CH, Jia X, Jardetzky O. Refined solution structures of the Escherichia coli trp holo- and aporepressor. Journal of Molecular Biology. 229: 735-46. PMID 8433368 DOI: 10.1006/Jmbi.1993.1076  1
1992 Pachter R, Arrowsmith CH, Jardetzky O. The effect of selective deuteration on magnetization transfer in larger proteins. Journal of Biomolecular Nmr. 2: 183-94. PMID 1422151 DOI: 10.1007/Bf01875529  1
1991 Arrowsmith C, Pachter R, Altman R, Jardetzky O. The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution. European Journal of Biochemistry / Febs. 202: 53-66. PMID 1935980 DOI: 10.1111/J.1432-1033.1991.Tb16344.X  1
1991 Czaplicki J, Arrowsmith C, Jardetzky O. Segmental differences in the stability of the trp-repressor peptide backbone. Journal of Biomolecular Nmr. 1: 349-61. PMID 1841704 DOI: 10.1007/Bf02192859  1
1991 Arrowsmith CH, Czaplicki J, Iyer SB, Jardetzky O. Unusual dynamic features of the trp repressor from Escherichia coli Journal of the American Chemical Society. 113: 4020-4022. DOI: 10.1021/Ja00010A070  1
1991 Arrowsmith CH, Kresge AJ, Tang YC. The base-catalyzed decomposition of nitramide: Mechanism of the second reaction pathway Journal of the American Chemical Society. 113: 179-182.  1
1990 Arrowsmith CH, Pachter R, Altman RB, Iyer SB, Jardetzky O. Sequence-specific 1H NMR assignments and secondary structure in solution of Escherichia coli trp repressor. Biochemistry. 29: 6332-41. PMID 2207078 DOI: 10.1021/Bi00479A002  1
1990 Arrowsmith CA, Williamson IP. Land information systems in local government and the role of the private sector Australian Surveyor. 35: 29-39. DOI: 10.1080/00050326.1990.10438640  1
1990 Arrowsmith CH, Treat‐Clemons L, Szilágyi L, Pachter R, Jardetzky O. The use of selective deuteration for the sequence specific 1H NMR assignment of larger proteins Makromolekulare Chemie. Macromolecular Symposia. 34: 33-46. DOI: 10.1002/Masy.19900340104  1
1989 Hyde EI, Ramesh V, Roberts GC, Arrowsmith CH, Treat-Clemons L, Klaic B, Jardetzky O. NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances. European Journal of Biochemistry / Febs. 183: 545-53. PMID 2673778 DOI: 10.1111/J.1432-1033.1989.Tb21083.X  1
1989 Arrowsmith CH, Carey J, Treat-Clemons L, Jardetzky O. NMR assignments for the amino-terminal residues of trp repressor and their role in DNA binding. Biochemistry. 28: 3875-9. PMID 2665811 DOI: 10.1021/Bi00435A037  1
1987 Aroella T, Arrowsmith CH, Hojatti M, Kresge AJ, Powell MF, Tang YS, Wang WH. The ionization of terminal acetylenes: Pseudoacid behavior Journal of the American Chemical Society. 109: 7198-7199.  1
1986 Arrowsmith CH, Kresge AJ. A correlation between β-hydrogen isotope effects on carbon-13 NMR chemical shifts in unsaturated systems and the strength of hyperconjugative interactions Journal of the American Chemical Society. 108: 7918-7920.  1
1986 Arrowsmith CH, Baitzer L, Jerry Kresge A, Powell MF, Tang YS. Tritium isotope effects on carbon-13 NMR chemical shifts Journal of the American Chemical Society. 108: 1356-1357.  1
1946 Ross J, Bel AC, Arrowsmith CJ, Gebhart AI. The stability and constitution of monoglycerides Oil &Amp; Soap. 23: 257-259. DOI: 10.1007/BF02696132  1
1942 Percy JH, Arrowsmith CJ. Conductometric assay of inorganic salt in the presence of wetting agents Industrial and Engineering Chemistry. 14: 151-153.  1
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