| Year |
Citation |
Score |
| 2023 |
Wang X, McKillop WM, Dlugi TA, Faber ML, Alvarez-Argote J, Chambers CB, Wilber A, Medin JA. A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice. The Journal of Gene Medicine. e3567. PMID 37455676 DOI: 10.1002/jgm.3567 |
0.307 |
|
| 2022 |
Nagree MS, Felizardo TC, Faber ML, Rybova J, Rupar CA, Foley SR, Fuller M, Fowler DH, Medin JA. Autologous, lentivirus-modified, T-rapa cell "micropharmacies" for lysosomal storage disorders. Embo Molecular Medicine. e14297. PMID 35298086 DOI: 10.15252/emmm.202114297 |
0.317 |
|
| 2021 |
Domm JM, Wootton SK, Medin JA, West ML. Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing. Molecular Genetics and Metabolism. PMID 34340879 DOI: 10.1016/j.ymgme.2021.07.006 |
0.313 |
|
| 2020 |
Oldham RAA, Faber ML, Keppel TR, Buchberger AR, Waas M, Hari P, Gundry RL, Medin JA. Discovery and validation of surface -glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets. Journal For Immunotherapy of Cancer. 8. PMID 32771993 DOI: 10.1136/Jitc-2020-000915 |
0.344 |
|
| 2019 |
Li Y, Xu Y, Benitez BA, Nagree MS, Dearborn JT, Jiang X, Guzman MA, Woloszynek JC, Giaramita A, Yip BK, Elsbernd J, Babcock MC, Lo M, Fowler SC, Wozniak DF, ... ... Medin JA, et al. Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. PMID 31527255 DOI: 10.1073/Pnas.1912108116 |
0.384 |
|
| 2019 |
Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA. Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 31186526 DOI: 10.1038/S41374-019-0271-4 |
0.337 |
|
| 2019 |
Nagree MS, Scalia S, McKillop WM, Medin JA. An update on gene therapy for lysosomal storage disorders. Expert Opinion On Biological Therapy. 1-16. PMID 31056978 DOI: 10.1080/14712598.2019.1607837 |
0.427 |
|
| 2019 |
Liu M, Juvet SC, Medin JA, Martinu T, Oishi H, Keshavjee S. Lentiviral interleukin-10 gene therapy: Safety and questions. The Journal of Thoracic and Cardiovascular Surgery. 157: 818-819. PMID 30669243 DOI: 10.1016/J.Jtcvs.2018.10.082 |
0.355 |
|
| 2019 |
Neschadim A, Medin JA. Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells. Methods in Molecular Biology (Clifton, N.J.). 1895: 149-163. PMID 30539536 DOI: 10.1007/978-1-4939-8922-5_12 |
0.773 |
|
| 2019 |
Nagree MS, Felizardo TC, Huang J, Fowler DH, Medin JA. Lentiviral-modified T Rapa cells as 'micropharmacies' for lysosomal diseases Molecular Genetics and Metabolism. 126: S105. DOI: 10.1016/J.Ymgme.2018.12.264 |
0.442 |
|
| 2019 |
Medin JA, Khan A, Huang J, Barber D, Anthony Rupar C, Auray-Blais C, Fraser G, Fowler DH, Keating A, West ML, Foley R. FACTs Fabry gene therapy clinical trial: Two-year data Molecular Genetics and Metabolism. 126: S99. DOI: 10.1016/J.Ymgme.2018.12.248 |
0.451 |
|
| 2018 |
Filomeno PA, Kim KP, Yoon N, Rashedi I, Dayan V, Kandel RA, Wang XH, Felizardo TC, Berinstein E, Jelveh S, Filomeno A, Medin JA, Ferguson PC, Keating A. Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery. Cytotherapy. PMID 30076069 DOI: 10.1016/J.Jcyt.2018.05.011 |
0.305 |
|
| 2018 |
Yu FPS, Amintas S, Levade T, Medin JA. Acid ceramidase deficiency: Farber disease and SMA-PME. Orphanet Journal of Rare Diseases. 13: 121. PMID 30029679 DOI: 10.1186/S13023-018-0845-Z |
0.342 |
|
| 2018 |
Oishi H, Juvet SC, Martinu T, Sato M, Medin JA, Liu M, Keshavjee S. A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice. The Journal of Thoracic and Cardiovascular Surgery. PMID 29937159 DOI: 10.1016/J.Jtcvs.2018.05.003 |
0.315 |
|
| 2018 |
Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S. Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. Journal of Visualized Experiments : Jove. PMID 29364266 DOI: 10.3791/55063 |
0.46 |
|
| 2018 |
Oldham RAA, Felizardo T, Zhu N, Fowler DH, Medin JA. CAR-Modified Th1/Tc1-Polarized T-Rapa Cells Dissociate Inflammatory Cytokine Secretion from Anti-Tumor Cytotoxicity Blood. 132: 2046-2046. DOI: 10.1182/Blood-2018-99-113642 |
0.411 |
|
| 2018 |
Nagree MS, Faber ML, Tate E, Schroeder MA, DiPersio JF, Medin JA. In vivo enrichment of transduced cells to enhance gene therapy for Fabry disease Molecular Genetics and Metabolism. 123: S102-S103. DOI: 10.1016/J.Ymgme.2017.12.271 |
0.456 |
|
| 2018 |
Molino S, Yu FP, Sikora J, Rasmussen S, Geurts AM, Turner PV, Medin JA. Hepatocellular dysfunction and gene expression changes in the acid ceramidase deficient mouse Molecular Genetics and Metabolism. 123: S98. DOI: 10.1016/J.Ymgme.2017.12.256 |
0.315 |
|
| 2017 |
Broglie L, Margolis D, Medin JA. Yin and Yang of mesenchymal stem cells and aplastic anemia. World Journal of Stem Cells. 9: 219-226. PMID 29321823 DOI: 10.4252/Wjsc.V9.I12.219 |
0.366 |
|
| 2017 |
Molino S, Tate E, McKillop WM, Medin JA. Sphingolipid pathway enzymes modulate cell fate and immune responses. Immunotherapy. 9: 1185-1198. PMID 29067886 DOI: 10.2217/Imt-2017-0089 |
0.409 |
|
| 2017 |
Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, ... ... Medin JA, et al. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease. Molecular Therapy. Methods & Clinical Development. 5: 241-258. PMID 28603745 DOI: 10.1016/J.Omtm.2017.05.003 |
0.44 |
|
| 2017 |
Oldham RAA, Medin JA. Practical Considerations for Chimeric Antigen Receptor Design and Delivery. Expert Opinion On Biological Therapy. PMID 28586264 DOI: 10.1080/14712598.2017.1339687 |
0.376 |
|
| 2017 |
Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan IC, Casas J, Fabrias G, Hampson DR, Levade T, ... ... Medin JA, et al. Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. The American Journal of Pathology. 187: 864-883. PMID 28342444 DOI: 10.1016/J.Ajpath.2016.12.005 |
0.333 |
|
| 2017 |
He X, Dworski S, Zhu C, DeAngelis V, Solyom A, Medin JA, Simonaro CM, Schuchman EH. Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice. Bba Clinical. 7: 85-96. PMID 28275553 DOI: 10.1016/J.Bbacli.2017.02.001 |
0.368 |
|
| 2016 |
Au BC, Lee CJ, Lopez-Perez O, Foltz W, Felizardo TC, Wang JCM, Huang J, Fan X, Madden M, Goldstein A, Jaffray DA, Moloo B, McCart JA, Medin JA. Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques. Biomedicines. 4. PMID 28536373 DOI: 10.3390/Biomedicines4010006 |
0.335 |
|
| 2016 |
Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML. Molecular Therapy. Methods & Clinical Development. 3: 16074. PMID 27933304 DOI: 10.1038/Mtm.2016.74 |
0.346 |
|
| 2016 |
Al-Hujaily EM, Oldham RA, Hari P, Medin JA. Development of Novel Immunotherapies for Multiple Myeloma. International Journal of Molecular Sciences. 17. PMID 27618026 DOI: 10.3390/Ijms17091506 |
0.351 |
|
| 2016 |
Resetca D, Neschadim A, Medin JA. Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 27488725 DOI: 10.1097/Cji.0000000000000134 |
0.757 |
|
| 2016 |
Piovan C, Giuliani E, Corna S, Scavullo C, Bossi S, Pema M, Medin JA, McKillop M, Au B, Bordignon C, Rizzardi GP, Bovolenta C. 703. Development of RD-MolPack-trLNGFR/dCK.DM.S74E Stable Packaging Cells Molecular Therapy. 24: S278. DOI: 10.1016/S1525-0016(16)33511-0 |
0.513 |
|
| 2016 |
Oldham RA, Berinstein EM, Medin JA. 407. A Novel Rabbit Antibody-Derived, Anti-CD123 LV/CAR Construct for AML Immunotherapy Molecular Therapy. 24: S161. DOI: 10.1016/S1525-0016(16)33216-6 |
0.374 |
|
| 2015 |
Nagree MS, López-Vásquez L, Medin JA. Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy. World Journal of Stem Cells. 7: 1233-50. PMID 26730268 DOI: 10.4252/Wjsc.V7.I11.1233 |
0.465 |
|
| 2015 |
Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA. Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis. Methods in Molecular Biology (Clifton, N.J.). 1317: 55-67. PMID 26072401 DOI: 10.1007/978-1-4939-2727-2_4 |
0.772 |
|
| 2015 |
Oldham RA, Berinstein EM, Medin JA. Lentiviral vectors in cancer immunotherapy. Immunotherapy. 7: 271-84. PMID 25804479 DOI: 10.2217/Imt.14.108 |
0.453 |
|
| 2015 |
McKillop WM, Au BC, Moncada C, Andreev N, Keever-Taylor CA, Drobyski WR, Minden MD, Paige CJ, Medin JA. 539. Clinical LV Design Incorporating Human-Derived Cell-Fate Control (Suicide) Elements Molecular Therapy. 23: S216-S217. DOI: 10.1016/S1525-0016(16)34148-X |
0.49 |
|
| 2015 |
Au BC, Liu Y, Huang J, Nelles M, Arruda A, Rothe M, Paul G, Schambach A, Barber DL, Minden MD, Paige CJ, Medin JA. 413. Pre-Clinical Preparation and Validation of Tumor Cell-Based IL-12 Immunotherapy for Acute Myeloid Leukemia Molecular Therapy. 23: S163. DOI: 10.1016/S1525-0016(16)34022-9 |
0.424 |
|
| 2015 |
Dworski S, Jones EE, Sikora J, Micsenyi M, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Kamani M, Dunn CK, Xuan I, Hampson DR, Carpentier S, Casas J, Fabrias G, ... ... Medin JA, et al. Spatial distribution of brain ceramides in an acid ceramidase deficient murine model: Subsequent histological manifestations and functional deficits Molecular Genetics and Metabolism. 114: S38-S39. DOI: 10.1016/J.Ymgme.2014.12.070 |
0.325 |
|
| 2014 |
Ricci MJ, Medin JA, Foley RS. Advances in haplo-identical stem cell transplantation in adults with high-risk hematological malignancies. World Journal of Stem Cells. 6: 380-90. PMID 25258660 DOI: 10.4252/Wjsc.V6.I4.380 |
0.324 |
|
| 2014 |
Nelles ME, Moreau JM, Furlonger CL, Berger A, Medin JA, Paige CJ. Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity. Cancer Immunology Research. 2: 1113-24. PMID 25154710 DOI: 10.1158/2326-6066.Cir-13-0208 |
0.408 |
|
| 2014 |
Rupar T, Khan A, Au BC, Tailor C, Rothe M, Bischof D, Sirrs S, Auray-Blais C, Prokopishyn N, O'Hoski P, Huang J, Paul G, Benabid R, Viswanathan S, Morel C, ... ... Medin JA, et al. Towards a clinical trial of lentivirus-mediated gene therapy for Fabry disease: In vitro patient cell mobilization and transduction outcomes Clinical Biochemistry. 47: 151. DOI: 10.1016/J.Clinbiochem.2014.07.079 |
0.397 |
|
| 2013 |
Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ. Localized interleukin-12 delivery for immunotherapy of solid tumours. Journal of Cellular and Molecular Medicine. 17: 1465-74. PMID 24251770 DOI: 10.1111/Jcmm.12121 |
0.353 |
|
| 2013 |
Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA. The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer. Plos One. 8: e78711. PMID 24194950 DOI: 10.1371/Journal.Pone.0078711 |
0.776 |
|
| 2013 |
Wang JC, Felizardo TC, Au BC, Fowler DH, Dekaban GA, Medin JA. Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways. Virology Journal. 10: 240. PMID 23870437 DOI: 10.1186/1743-422X-10-240 |
0.362 |
|
| 2013 |
Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, ... ... Medin JA, et al. Systemic ceramide accumulation leads to severe and varied pathological consequences. Embo Molecular Medicine. 5: 827-42. PMID 23681708 DOI: 10.1002/Emmm.201202301 |
0.399 |
|
| 2013 |
Felizardo TC, Foley J, Steed K, Dropulic B, Amarnath S, Medin JA, Fowler DH. Harnessing autophagy for cell fate control gene therapy. Autophagy. 9: 1069-79. PMID 23633667 DOI: 10.4161/Auto.24639 |
0.481 |
|
| 2013 |
Hirayama S, Sato M, Loisel-Meyer S, Matsuda Y, Oishi H, Guan Z, Saito T, Yeung J, Cypel M, Hwang DM, Medin JA, Liu M, Keshavjee S. Lentivirus IL-10 gene therapy down-regulates IL-17 and attenuates mouse orthotopic lung allograft rejection American Journal of Transplantation. 13: 1586-1593. PMID 23601206 DOI: 10.1111/Ajt.12230 |
0.326 |
|
| 2013 |
Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC. Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity. Brain, Behavior, and Immunity. 30: 103-14. PMID 23369732 DOI: 10.1016/J.Bbi.2013.01.079 |
0.378 |
|
| 2013 |
Yannarelli G, Pacienza N, Cuniberti L, Medin J, Davies J, Keating A. Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells. Stem Cells (Dayton, Ohio). 31: 215-20. PMID 23097343 DOI: 10.1002/Stem.1262 |
0.391 |
|
| 2013 |
Yannarelli G, Dayan V, Pacienza N, Lee CJ, Medin J, Keating A. Human umbilical cord perivascular cells exhibit enhanced cardiomyocyte reprogramming and cardiac function after experimental acute myocardial infarction. Cell Transplantation. 22: 1651-66. PMID 23043977 DOI: 10.3727/096368912X657675 |
0.388 |
|
| 2013 |
Scaife M, Pacienza N, Au BC, Wang JC, Devine S, Scheid E, Lee CJ, Lopez-Perez O, Neschadim A, Fowler DH, Foley R, Medin JA. Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes. Gene Therapy. 20: 24-34. PMID 22241175 DOI: 10.1038/Gt.2011.210 |
0.785 |
|
| 2013 |
Dworski S, Berger A, Furlonger C, Paige CJ, Medin JA. BMT Doubles The Lifespan Of A Mouse Model Of Farber Disease and Corrects Hematopoietic Defects Blood. 122: 1997-1997. DOI: 10.1182/Blood.V122.21.1997.1997 |
0.371 |
|
| 2012 |
Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA. Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia. Human Gene Therapy. 23: 1280-9. PMID 22998370 DOI: 10.1089/Hum.2012.063 |
0.344 |
|
| 2012 |
Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA. Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1454-61. PMID 22472949 DOI: 10.1038/Mt.2012.64 |
0.398 |
|
| 2012 |
Neschadim A, Wang JC, Lavie A, Medin JA. Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer. Cancer Gene Therapy. 19: 320-7. PMID 22388453 DOI: 10.1038/Cgt.2012.4 |
0.759 |
|
| 2012 |
Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA. Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1002-13. PMID 22273576 DOI: 10.1038/Mt.2011.298 |
0.784 |
|
| 2012 |
Swift BE, Williams BA, Kosaka Y, Wang XH, Medin JA, Viswanathan S, Martinez-Lopez J, Keating A. Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model. Haematologica. 97: 1020-8. PMID 22271890 DOI: 10.3324/Haematol.2011.054254 |
0.45 |
|
| 2012 |
Berthod F, Symes J, Tremblay N, Medin JA, Auger FA. Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. Journal of Cellular Physiology. 227: 2130-7. PMID 21769871 DOI: 10.1002/Jcp.22943 |
0.342 |
|
| 2012 |
Dworski S, Berger A, Yoshimitsu M, Alayoubi A, Au B, Exertier M, Forster J, Furlonger C, Wang JC, Takenaka T, Paige CJ, Medin JA. Systemic Ceramide Accumulation Causes Dysregulated Hematopoiesis Blood. 120: 3461-3461. DOI: 10.1182/Blood.V120.21.3461.3461 |
0.386 |
|
| 2012 |
Dworski S, Mejia-Guerrero S, Pacienza N, Au B, Medin J. Gene Expression Profiling of a Mouse Model of Fabry Disease Molecular Genetics and Metabolism. 105: S27. DOI: 10.1016/J.Ymgme.2011.11.050 |
0.341 |
|
| 2011 |
Amarnath S, Mangus CW, Wang JC, Wei F, He A, Kapoor V, Foley JE, Massey PR, Felizardo TC, Riley JL, Levine BL, June CH, Medin JA, Fowler DH. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Science Translational Medicine. 3: 111ra120. PMID 22133721 DOI: 10.1126/Scitranslmed.3003130 |
0.362 |
|
| 2011 |
Hirayama S, Sato M, Liu M, Loisel-Meyer S, Yeung JC, Wagnetz D, Cypel M, Zehong G, Medin JA, Keshavjee S. Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways. Human Gene Therapy. 22: 1453-60. PMID 21568692 DOI: 10.1089/Hum.2010.225 |
0.337 |
|
| 2011 |
Felizardo TC, Wang JCM, McGray RAJ, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA. Differential immune responses mediated by adenovirus-and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model Gene Therapy. 18: 986-995. PMID 21490686 DOI: 10.1038/Gt.2011.53 |
0.34 |
|
| 2011 |
Siegers GM, Dhamko H, Wang XH, Mathieson AM, Kosaka Y, Felizardo TC, Medin JA, Tohda S, Schueler J, Fisch P, Keating A. Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells. Cytotherapy. 13: 753-64. PMID 21314241 DOI: 10.3109/14653249.2011.553595 |
0.383 |
|
| 2011 |
Siegers GM, Felizardo TC, Mathieson AM, Kosaka Y, Wang XH, Medin JA, Keating A. Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model. Plos One. 6: e16700. PMID 21304898 DOI: 10.1371/Journal.Pone.0016700 |
0.417 |
|
| 2011 |
Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA. Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. Human Gene Therapy. 22: 679-87. PMID 21280983 DOI: 10.1089/Hum.2010.195 |
0.768 |
|
| 2011 |
Wang AY, Crome SQ, Jenkins KM, Medin JA, Bramson JL, Levings MK. Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production. Cancer Immunology, Immunotherapy : Cii. 60: 381-8. PMID 21153637 DOI: 10.1007/S00262-010-0948-4 |
0.332 |
|
| 2011 |
Lee CJ, Fan X, Guo X, Medin JA. Promoter-specific lentivectors for long-term, cardiac-directed therapy of Fabry disease. Journal of Cardiology. 57: 115-22. PMID 20846825 DOI: 10.1016/J.Jjcc.2010.08.003 |
0.333 |
|
| 2011 |
Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T. Sequencing and characterization of the porcine α-galactosidase A gene: towards the generation of a porcine model for Fabry disease. Molecular Biology Reports. 38: 3145-52. PMID 20131008 DOI: 10.1007/S11033-010-9985-5 |
0.329 |
|
| 2011 |
Pacienza N, Mizue N, Scaife M, Medin J. MGMT-based Selection of Lentivector Transduced Cells: Application to Fabry Disease Molecular Genetics and Metabolism. 102: S32-S33. DOI: 10.1016/J.Ymgme.2010.11.110 |
0.333 |
|
| 2011 |
Medin J, Pacienza N, Mizue N, Fan X, Scaife M. Enhanced Gb3 reduction mediated by Lentivector Transduction of human CD34+ bone marrow-derived cells in a Novel Fabry/NOD/SCID Xenograft model Molecular Genetics and Metabolism. 102: S29. DOI: 10.1016/J.Ymgme.2010.11.097 |
0.342 |
|
| 2010 |
Romieu-Mourez R, François M, Abate A, Boivin MN, Birman E, Bailey D, Bramson JL, Forner K, Young YK, Medin JA, Galipeau J. Mesenchymal stromal cells expressing ErbB-2/neu elicit protective antibreast tumor immunity in vivo, which is paradoxically suppressed by IFN-gamma and tumor necrosis factor-alpha priming. Cancer Research. 70: 7742-7. PMID 20924101 DOI: 10.1158/0008-5472.Can-10-0296 |
0.358 |
|
| 2010 |
Likar Y, Zurita J, Dobrenkov K, Shenker L, Cai S, Neschadim A, Medin JA, Sadelain M, Hricak H, Ponomarev V. A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 1395-403. PMID 20810757 DOI: 10.2967/Jnumed.109.074344 |
0.728 |
|
| 2010 |
Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenaka T, Medin JA. Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice. Molecular Medicine (Cambridge, Mass.). 16: 216-21. PMID 20454522 DOI: 10.2119/Molmed.2009.00163 |
0.371 |
|
| 2010 |
Fan X, Lang H, Zhou X, Zhang L, Yin R, Maciejko J, Giannitsos V, Motyka B, Medin JA, Platt JL, West LJ. Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction. Human Gene Therapy. 21: 877-890. PMID 20163247 DOI: 10.1089/Hum.2008.089 |
0.394 |
|
| 2010 |
Elschenbroich S, Kim Y, Medin JA, Kislinger T. Isolation of cell surface proteins for mass spectrometry-based proteomics. Expert Review of Proteomics. 7: 141-54. PMID 20121483 DOI: 10.1586/Epr.09.97 |
0.329 |
|
| 2010 |
Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. Regulatory Peptides. 159: 44-53. PMID 19778557 DOI: 10.1016/J.Regpep.2009.09.007 |
0.709 |
|
| 2010 |
Hirayama S, Sato M, Liu M, Zehong G, Loisel-Meyer S, Wagnetz D, Yeung JC, Cypel M, Medin JA, Keshavjee S. REPEATED-DOSE, LENTIVIRAL-MEDIATED IL-10 AIRWAY GENE DELIVERY TARGETING CHRONIC TRANSPLANTED AIRWAY ALLOGRAFT OBLITERATION Transplantation Journal. 90: 94. DOI: 10.1097/00007890-201007272-00181 |
0.308 |
|
| 2009 |
Cypel M, Liu M, Rubacha M, Yeung JC, Hirayama S, Anraku M, Sato M, Medin J, Davidson BL, de Perrot M, Waddell TK, Slutsky AS, Keshavjee S. Functional repair of human donor lungs by IL-10 gene therapy. Science Translational Medicine. 1: 4ra9. PMID 20368171 DOI: 10.1126/Scitranslmed.3000266 |
0.319 |
|
| 2009 |
Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA. Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection. Journal of Cardiology. 54: 245-54. PMID 19782262 DOI: 10.1016/J.Jjcc.2009.05.010 |
0.332 |
|
| 2009 |
Scaife MD, Neschadim A, Fowler DH, Medin JA. Novel application of lentiviral vectors towards treatment of graft-versus-host disease. Expert Opinion On Biological Therapy. 9: 749-61. PMID 19456209 DOI: 10.1517/14712590903002021 |
0.751 |
|
| 2009 |
Loisel-Meyer S, Felizardo T, Mariotti J, Mossoba ME, Foley JE, Kammerer R, Mizue N, Keefe R, McCart JA, Zimmermann W, Dropulic B, Fowler DH, Medin JA. Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection. Molecular Cancer Therapeutics. 8: 692-702. PMID 19276164 DOI: 10.1158/1535-7163.Mct-08-0769 |
0.397 |
|
| 2009 |
Symes JC, Siatskas C, Fowler DH, Medin JA. Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells Cancer Gene Therapy. 16: 439-452. PMID 19096446 DOI: 10.1038/Cgt.2008.96 |
0.431 |
|
| 2009 |
Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA. Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 262-8. PMID 19002160 DOI: 10.1038/Mt.2008.244 |
0.336 |
|
| 2009 |
Surzyn M, Symes J, Medin JA, Sefton MV. IL-10 secretion increases signal persistence of HEMA-MMA-microencapsulated luciferase-modified CHO fibroblasts in mice. Tissue Engineering. Part A. 15: 127-36. PMID 18710337 DOI: 10.1089/Ten.Tea.2008.0028 |
0.428 |
|
| 2009 |
Rodriguez-Sosa JR, Silvertown JD, Foster RA, Medin JA, Hahnel A. Transduction and transplantation of spermatogonia into the testis of ram lambs through the extra-testicular rete Reproduction in Domestic Animals. 44: 612-620. PMID 18694428 DOI: 10.1111/J.1439-0531.2007.01030.X |
0.355 |
|
| 2009 |
Labbe A, Nelles M, Walia J, Jia L, Furlonger C, Nonaka T, Medin JA, Paige CJ. IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy. Journal of Cellular and Molecular Medicine. 13: 1962-76. PMID 18624776 DOI: 10.1111/J.1582-4934.2008.00412.X |
0.339 |
|
| 2009 |
Pacienza NA, Mizue N, Scaife M, Foley R, Medin JA. Use of MGMT Resistance to Enrich for Transduced Hematopoietic Cells in Gene Therapy for Fabry Disease. Blood. 114: 3584-3584. DOI: 10.1182/Blood.V114.22.3584.3584 |
0.47 |
|
| 2009 |
Amarnath S, Wang JC, Massey PR, Riley JL, Levine B, June CH, Medin JA, Fowler D. PD-L1 Immuno-Gene Therapy Under Cell Fate Control: Persistence of Cellular Delivery Vehicle and Transgene Expression. Blood. 114: 3580-3580. DOI: 10.1182/Blood.V114.22.3580.3580 |
0.422 |
|
| 2009 |
Pacienza NA, Mizue N, Yoshimitsu M, Scaife M, Foley R, Medin JA. Generation and Implementation of a Novel Murine Xenograft Model for Evaluating Human Hematopoietic Cell-Targeted Gene Therapies for Fabry Disease. Blood. 114: 3576-3576. DOI: 10.1182/Blood.V114.22.3576.3576 |
0.373 |
|
| 2009 |
Medin J, Walia J, Neschadim A, Fan X, Madden M, Cheung F, Jaffray D, Levade T, Brady R, McCart JA. 87. Outcomes of testing Lentivector-mediated Gene Therapy for Farber Disease in Non-Human Primates Molecular Genetics and Metabolism. 96: S31. DOI: 10.1016/J.Ymgme.2008.11.088 |
0.718 |
|
| 2008 |
Francia G, Emmenegger U, Lee CR, Shaked Y, Folkins C, Mossoba M, Medin JA, Man S, Zhu Z, Witte L, Kerbel RS. Long-term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-human choriogonadotropin secreting tumor cell lines. Molecular Cancer Therapeutics. 7: 3452-9. PMID 18852148 DOI: 10.1158/1535-7163.Mct-08-0200 |
0.33 |
|
| 2008 |
Ramsubir S, Nonaka T, Girbés CB, Carpentier S, Levade T, Medin JA. In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. Molecular Genetics and Metabolism. 95: 133-41. PMID 18805722 DOI: 10.1016/J.Ymgme.2008.08.003 |
0.476 |
|
| 2008 |
Symes JC, Kurin M, Fleshner NE, Medin JA. Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel. Molecular Cancer Therapeutics. 7: 3018-28. PMID 18790782 DOI: 10.1158/1535-7163.Mct-08-0335 |
0.362 |
|
| 2008 |
Loisel-Meyer S, Foley R, Medin JA. Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials. Frontiers in Bioscience : a Journal and Virtual Library. 13: 3202-14. PMID 18508428 DOI: 10.2741/2921 |
0.357 |
|
| 2008 |
Mossoba ME, Walia JS, Rasaiah VI, Buxhoeveden N, Head R, Ying C, Foley JE, Bramson JL, Fowler DH, Medin JA. Tumor protection following vaccination with low doses of lentivirally transduced DCs expressing the self-antigen erbB2 Molecular Therapy. 16: 607-617. PMID 18180774 DOI: 10.1038/Sj.Mt.6300390 |
0.378 |
|
| 2008 |
Formigli L, Perna AM, Meacci E, Cinci L, Margheri M, Nistri S, Tani A, Silvertown J, Orlandini G, Porciani C, Zecchi-Orlandini S, Medin J, Bani D. Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling. Journal of Cellular and Molecular Medicine. 11: 1087-100. PMID 17979884 DOI: 10.1111/J.1582-4934.2007.00111.X |
0.333 |
|
| 2008 |
Siegers GM, Al-Beirouti BM, Mathieson AM, Felizardo TC, Helke S, Medin JA, Keating A. Gamma Delta T Cells (GDTCs) to Eliminate Minimal Residual Disease (MRD) in Chronic Myeloid Leukemia (CML) : A Pre-Clinical Model Blood. 112: 574-574. DOI: 10.1182/Blood.V112.11.574.574 |
0.368 |
|
| 2007 |
Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L. Lentivirally Transduced Recipient-derived Dendritic Cells Serve to Ex Vivo Expand Functional FcRγ-sufficient Double-negative Regulatory T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 818-824. PMID 28192704 DOI: 10.1038/Sj.Mt.6300082 |
0.413 |
|
| 2007 |
Neschadim A, McCart JA, Keating A, Medin JA. A roadmap to safe, efficient, and stable lentivirus-mediated gene therapy with hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 13: 1407-16. PMID 18022569 DOI: 10.1016/J.Bbmt.2007.09.014 |
0.764 |
|
| 2007 |
Bastianutto C, Mian A, Symes J, Mocanu J, Alajez N, Sleep G, Shi W, Keating A, Crump M, Gospodarowicz M, Medin J, Minden M, Liu FF. Local radiotherapy induces homing of hematopoietic stem cells to the irradiated bone marrow. Cancer Research. 67: 10112-6. PMID 17974951 DOI: 10.1158/0008-5472.Can-07-2192 |
0.304 |
|
| 2007 |
Ramsubir S, Yoshimitsu M, Medin JA. Anti-CD25 targeted killing of bicistronically transduced cells: a novel safety mechanism against retroviral genotoxicity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1174-81. PMID 17387334 DOI: 10.1038/Sj.Mt.6300147 |
0.456 |
|
| 2007 |
Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA. Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 962-70. PMID 17375075 DOI: 10.1038/Mt.Sj.6300122 |
0.785 |
|
| 2007 |
Liang SB, Yoshimitsu M, Poeppl A, Rasaiah VI, Cai J, Fowler DH, Medin JA. Multiple reduced-intensity conditioning regimens facilitate correction of Fabry mice after transplantation of transduced cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 618-27. PMID 17228315 DOI: 10.1038/Sj.Mt.6300075 |
0.458 |
|
| 2007 |
Silvertown JD, Symes JC, Neschadim A, Nonaka T, Kao JC, Summerlee AJ, Medin JA. Analog of H2 relaxin exhibits antagonistic properties and impairs prostate tumor growth. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 754-65. PMID 17197386 DOI: 10.1096/Fj.06-6847Com |
0.713 |
|
| 2007 |
Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka T, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA. Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells. Gene Therapy. 14: 256-65. PMID 16929352 DOI: 10.1038/Sj.Gt.3302839 |
0.412 |
|
| 2007 |
Ayach BB, Higuchi K, Dawood F, Chen M, Tata N, Galipeau J, Stewart DJ, Stanford WL, Medin JA, Liu PP. CXCR4 Synergistically Activates FLT3 Receptor and Regulates Mobilization of Innate Immune and Stem Progenitor Cells Post-Myocardial Infarction Journal of Cardiac Failure. 13: S107. DOI: 10.1016/J.Cardfail.2007.06.420 |
0.312 |
|
| 2006 |
Mossoba ME, Medin JA. Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials. Expert Review of Vaccines. 5: 717-32. PMID 17181444 DOI: 10.1586/14760584.5.5.717 |
0.395 |
|
| 2006 |
Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA. Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A. Circulation Journal : Official Journal of the Japanese Circulation Society. 70: 1503-8. PMID 17062978 DOI: 10.1253/Circj.70.1503 |
0.356 |
|
| 2006 |
Mattocks M, Bagovich M, De Rosa M, Bond S, Binnington B, Rasaiah VI, Medin J, Lingwood C. Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1. Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model. The Febs Journal. 273: 2064-75. PMID 16724420 DOI: 10.1111/J.1742-4658.2006.05223.X |
0.349 |
|
| 2006 |
Silvertown JD, Walia JS, Summerlee AJ, Medin JA. Functional expression of mouse relaxin and mouse relaxin-3 in the lung from an Ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery. Endocrinology. 147: 3797-808. PMID 16709614 DOI: 10.1210/En.2006-0028 |
0.322 |
|
| 2006 |
Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M, Higuchi K, Siatskas C, Lee P, Lim H, Zhang J, Cukerman E, Stanford WL, Medin JA, Liu PP. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 103: 2304-9. PMID 16467148 DOI: 10.1073/Pnas.0510997103 |
0.332 |
|
| 2006 |
Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA. H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. International Journal of Cancer. 118: 62-73. PMID 16049981 DOI: 10.1002/Ijc.21288 |
0.337 |
|
| 2006 |
Mossoba ME, Walia JS, Rasaiah VI, Fowler DH, Medin JA. Overcoming Self-Tolerance: Long-Term Protection Against Specific erbB2-Expressing Prostate Tumors Using Low Doses of Lentivirus-Transduced DCs. Blood. 108: 3696-3696. DOI: 10.1182/Blood.V108.11.3696.3696 |
0.382 |
|
| 2006 |
Neschadim A, Sato T, Fowler DH, Lavie A, Medin JA. Development of Improved Lentiviral ‘Suicide’ Gene Therapy for the Management of GvHD and GvL/GvT Responses in Allogeneic BMT. Blood. 108: 3256-3256. DOI: 10.1182/Blood.V108.11.3256.3256 |
0.784 |
|
| 2005 |
Lund N, Branch DR, Sakac D, Lingwood CA, Siatskas C, Robinson CJ, Brady RO, Medin JA. Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus. Aids (London, England). 19: 1543-6. PMID 16135910 DOI: 10.1097/01.Aids.0000183521.90878.79 |
0.304 |
|
| 2005 |
Siatskas C, Underwood J, Ramezani A, Hawley RG, Medin JA. Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1752-4. PMID 16076962 DOI: 10.1096/Fj.05-4006Fje |
0.413 |
|
| 2005 |
Silvertown JD, Walia JS, Medin JA. Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA. Developmental and Comparative Immunology. 29: 989-1002. PMID 15935473 DOI: 10.1016/J.Dci.2005.02.007 |
0.388 |
|
| 2005 |
Medin JA, Liang SB, Hou JW, Kelley LS, Peace DJ, Fowler DH. Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo. Cancer Gene Therapy. 12: 540-51. PMID 15678150 DOI: 10.1038/Sj.Cgt.7700810 |
0.43 |
|
| 2005 |
Walia JS, Yoshimitsu M, Silvertown JD, Poeppl A, Rasaiah VI, Donahue RE, Andrews RG, McCart JA, Medin JA. Initiation of a Pre-Clinical Gene Therapy Study in Non-Human Primates Using Lentivectors Targeting Hematopoietic Cells for Correction of Fabry Disease. Blood. 106: 5542-5542. DOI: 10.1182/Blood.V106.11.5542.5542 |
0.487 |
|
| 2005 |
Sato T, Neschadim A, Rasaiah VI, Konrad M, Fowler DH, Lavie A, Medin JA. A Novel Suicide Gene Therapy Approach for Reduction of GvHD Using Lentiviral Delivery of a Modified Human Thymidylate Monophosphate Kinase. Blood. 106: 5252-5252. DOI: 10.1182/Blood.V106.11.5252.5252 |
0.787 |
|
| 2005 |
Sato T, Neschadim A, Rasaiah VI, Konrad M, Fowler DH, Lavie A, Medin JA. Improved Suicide Gene Therapy: Lentiviral Gene Transfer of Equine Herpes Virus Type 4 Thymidine Kinase into Target Cells. Blood. 106: 5251-5251. DOI: 10.1182/Blood.V106.11.5251.5251 |
0.785 |
|
| 2005 |
Medin JA, Liang S, Poeppl A, Yoshimitsu M, Walia JS, Cai J, Rasaiah VI, Fowler DH. Functional Engraftment of Retrovirally Transduced and Pre-Selected Hematopoietic Cells into Partially Ablated Recipient Fabry Mice. Blood. 106: 3023-3023. DOI: 10.1182/Blood.V106.11.3023.3023 |
0.472 |
|
| 2005 |
Yoshimitsu M, Siatskas C, Liang S, Rasaiah VI, Higuchi K, Murray GJ, Takenaka T, Tei C, Brady RO, Medin JA. Long-Term and Sustained Correction of the α-Galactosidase A Deficiency in Fabry Mice and Patient Cells Receiving Lentivirally Transduced Hematopoietic Stem/Progenitor Cells. Blood. 106: 1285-1285. DOI: 10.1182/Blood.V106.11.1285.1285 |
0.47 |
|
| 2004 |
Yoshimitsu M, Sato T, Tao K, Walia JS, Rasaiah VI, Sleep GT, Murray GJ, Poeppl AG, Underwood J, West L, Brady RO, Medin JA. Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 101: 16909-14. PMID 15550536 DOI: 10.1073/Pnas.0407572101 |
0.37 |
|
| 2004 |
Smith SL, Kiss J, Siatskas C, Medin JA, Moldwin RL. Enhanced effect of vascular endothelial growth factor, thrombopoietin peptide agonist, SCF, and Flt3-L on LTC-IC and reporter gene transduction from umbilical cord blood CD34+ cells. Transfusion. 44: 438-49. PMID 14996204 DOI: 10.1111/J.1537-2995.2003.00661.X |
0.309 |
|
| 2004 |
Bielawski JC, Fowler DH, Medin JA. 950. FasL- Over-Expressing T Lymphocytes as Effector Cells in Anti-Prostate Cancer Gene Therapy Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.893 |
0.435 |
|
| 2004 |
Ramsubir SM, Tardy C, Carpentier S, Levade T, Medin JA. 868. Enhancement of Gene Therapy Approaches for the Correction of Farber Disease Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.775 |
0.49 |
|
| 2004 |
Yoshimitsu M, Tao K, Fan X, West L, Medin JA. 861. Neonatal Gene Therapy with a Lentiviral Vector Results in Therapeutic Levels of |[alpha]|-Galactosidase A Correction in Fabry Mice Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.768 |
0.46 |
|
| 2003 |
Li JH, Shi W, Chia M, Sanchez-Sweatman O, Siatskas C, Huang D, Busson P, Klamut H, Yeh WC, Richardson C, O'Sullivan B, Gullane P, Neligan P, Medin J, Liu FF. Efficacy of targeted FasL in nasopharyngeal carcinoma. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 964-73. PMID 14664799 DOI: 10.1016/J.Ymthe.2003.08.018 |
0.452 |
|
| 2003 |
Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T. The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1144-6. PMID 12692077 DOI: 10.1096/Fj.02-1053Fje |
0.381 |
|
| 2002 |
Medin JA, Fowler DH. Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: beyond efficiency issues. Journal of Cellular Biochemistry. Supplement. 38: 46-54. PMID 12046849 DOI: 10.1002/Jcb.10052 |
0.404 |
|
| 2002 |
Medin JA, Fowler DH. Obstacles to human hematopoietic stem cell transduction by recombinant adeno-associated virus 2 vectors Journal of Cellular Biochemistry. 85: 39-45. DOI: 10.1002/jcb.10053 |
0.357 |
|
| 2001 |
Sitaskas C, Medin JA. Gene therapy for Fabry disease Journal of Inherited Metabolic Disease. 24: 25-41. PMID 11758676 DOI: 10.1023/A:1012455421014 |
0.461 |
|
| 2001 |
Qin G, Takenaka T, Telsch K, Kelley L, Howard T, Levade T, Deans R, Howard BH, Malech HL, Brady RO, Medin JA. Preselective gene therapy for Fabry disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 3428-33. PMID 11248095 DOI: 10.1073/Pnas.061020598 |
0.479 |
|
| 2000 |
Takenaka T, Murray GJ, Qin G, Quirk JM, Ohshima T, Qasba P, Clark K, Kulkarni AB, Brady RO, Medin JA. Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 7515-20. PMID 10840053 DOI: 10.1073/Pnas.120177997 |
0.38 |
|
| 2000 |
Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T. Stress-induced apoptosis is not mediated by endolysosomal ceramide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 36-47. PMID 10627278 DOI: 10.1096/Fasebj.14.1.36 |
0.341 |
|
| 1999 |
Takenaka T, Qin G, Brady RO, Medin JA. Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease. Human Gene Therapy. 10: 1931-9. PMID 10466627 DOI: 10.1089/10430349950017293 |
0.358 |
|
| 1999 |
Takenaka T, Hendrickson CS, Tworek DM, Tudor M, Schiffmann R, Brady RO, Medin JA. Enzymatic and functional correction along with long-term enzyme secretion from transduced bone marrow hematopoietic stem/progenitor and stromal cells derived from patients with Fabry disease. Experimental Hematology. 27: 1149-59. PMID 10390190 DOI: 10.1016/S0301-472X(99)00050-8 |
0.414 |
|
| 1999 |
Medin JA, Brandt JE, Rozler E, Nelson M, Bartholomew A, Li C, Turian J, Chute J, Chung T, Hoffman R. Ex vivo expansion and genetic marking of primitive human and baboon hematopoietic cells Annals of the New York Academy of Sciences. 872: 233-242. PMID 10372126 DOI: 10.1111/J.1749-6632.1999.Tb08468.X |
0.454 |
|
| 1999 |
Medin JA, Takenaka T, Carpentier S, Garcia V, Basile JP, Segui B, Andrieu-Abadie N, Auge N, Salvayre R, Levade T. Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells Human Gene Therapy. 10: 1321-1329. PMID 10365663 DOI: 10.1089/10430349950018003 |
0.411 |
|
| 1998 |
Pemrick SM, Abarzúa P, Kratzeisen C, Marks MS, Medin JA, Ozato K, Grippo JF. Characterization of the chimeric retinoic acid receptor RARalpha/VDR. Leukemia. 12: 554-62. PMID 9557614 DOI: 10.1038/Sj.Leu.2400937 |
0.308 |
|
| 1997 |
Medin JA, Karlsson S. Viral vectors for gene therapy of hematopoietic cells Immunotechnology. 3: 3-19. PMID 9154464 DOI: 10.1016/S1380-2933(96)00059-0 |
0.491 |
|
| 1997 |
Nuñez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH. Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor Molecular and Cellular Endocrinology. 127: 27-40. PMID 9099898 DOI: 10.1016/S0303-7207(96)03980-9 |
0.318 |
|
| 1997 |
Medin JA, Karlsson S. Selection of retrovirally transduced cells to enhance the efficiency of gene therapy Proceedings of the Association of American Physicians. 109: 111-119. PMID 9069579 |
0.322 |
|
| 1996 |
Medin JA, Tudor M, Simovitch R, Quirk JM, Jacobson S, Murray GJ, Brady RO. Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector. Proceedings of the National Academy of Sciences of the United States of America. 93: 7917-22. PMID 8755577 DOI: 10.1073/Pnas.93.15.7917 |
0.426 |
|
| 1996 |
Medin JA, Migita M, Pawliuk R, Jacobson S, Amiri M, Kluepfel-Stahl S, Brady RO, Humphries RK, Karlsson S. A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients. Blood. 87: 1754-62. PMID 8634421 DOI: 10.1182/Blood.V87.5.1754.Bloodjournal8751754 |
0.495 |
|
| 1995 |
Migita M, Medin JA, Pawliuk R, Jacobson S, Nagle JW, Anderson S, Amiri M, Humphries RK, Karlsson S. Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors Proceedings of the National Academy of Sciences of the United States of America. 92: 12075-12079. PMID 8618847 DOI: 10.1073/Pnas.92.26.12075 |
0.457 |
|
| 1995 |
Nunez SB, Medin JA, Wang HKK, Ozato K, Wahli W, Segars J. Retinoid X receptor β and peroxisome proliferator-activated receptor activate an estrogen response element Recent Progress in Hormone Research. 50: 409-415. PMID 7740175 DOI: 10.1016/B978-0-12-571150-0.50029-9 |
0.303 |
|
| 1995 |
Schiffmann R, Medin JA, Ward JM, Stahl S, Cottler-Fox M, Karlsson S. Transfer of the human glucocerebrosidase gene into hematopoietic stem cells of nonablated recipients: Successful engraftment and long-term expression of the transgene Blood. 86: 1218-1227. PMID 7620175 DOI: 10.1182/Blood.V86.3.1218.Bloodjournal8631218 |
0.432 |
|
| 1990 |
Medin JA, Hunt L, Gathy K, Evans RK, Coleman MS. Efficient, low-cost protein factories: expression of human adenosine deaminase in baculovirus-infected insect larvae. Proceedings of the National Academy of Sciences of the United States of America. 87: 2760-4. PMID 2181448 DOI: 10.1073/Pnas.87.7.2760 |
0.361 |
|
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