Jeffrey A. Medin - Publications

Medical Biophysics University of Toronto, Toronto, ON, Canada 
Molecular Biology, Immunology

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Neschadim A, Medin JA. Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells. Methods in Molecular Biology (Clifton, N.J.). 1895: 149-163. PMID 30539536 DOI: 10.1007/978-1-4939-8922-5_12  1
2017 Nomura R, Sato T, Sato Y, Medin JA, Kushimoto S, Yanagisawa T. Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. Redox Biology. 13: 407-417. PMID 28683400 DOI: 10.1016/j.redox.2017.06.011  0.4
2016 Al-Hujaily EM, Oldham RA, Hari P, Medin JA. Development of Novel Immunotherapies for Multiple Myeloma. International Journal of Molecular Sciences. 17. PMID 27618026 DOI: 10.3390/ijms17091506  0.72
2016 Provençal P, Boutin M, Dworski S, Au B, Medin JA, Auray-Blais C. Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry. Bioanalysis. 8: 1793-807. PMID 27523577 DOI: 10.4155/bio-2016-0116  0.72
2016 Resetca D, Neschadim A, Medin JA. Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 27488725 DOI: 10.1097/CJI.0000000000000134  0.72
2015 Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA. Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis. Methods in Molecular Biology (Clifton, N.J.). 1317: 55-67. PMID 26072401 DOI: 10.1007/978-1-4939-2727-2_4  0.72
2015 Oldham RA, Berinstein EM, Medin JA. Lentiviral vectors in cancer immunotherapy. Immunotherapy. 7: 271-84. PMID 25804479 DOI: 10.2217/imt.14.108  0.72
2015 Dworski S, Berger A, Furlonger C, Moreau JM, Yoshimitsu M, Trentadue J, Au BC, Paige CJ, Medin JA. Markedly perturbed hematopoiesis in acid ceramidase deficient mice. Haematologica. 100: e162-5. PMID 25682603 DOI: 10.3324/haematol.2014.108530  0.72
2015 Ellen Jones E, Dworski S, Kamani M, Canals D, Wada M, Liu X, Hannun YA, Norris J, Medin JA, Drake RR. Detection and distribution of sphingolipids in tissue by FTICR MALDI-imaging mass spectrometry Bioactive Sphingolipids in Cancer Biology and Therapy. 339-358. DOI: 10.1007/978-3-319-20750-6_15  0.72
2014 Nelles ME, Moreau JM, Furlonger CL, Berger A, Medin JA, Paige CJ. Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity. Cancer Immunology Research. 2: 1113-24. PMID 25154710 DOI: 10.1158/2326-6066.CIR-13-0208  0.72
2014 Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Analytical Chemistry. 86: 8303-11. PMID 25072097 DOI: 10.1021/ac501937d  0.72
2013 Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ. Localized interleukin-12 delivery for immunotherapy of solid tumours. Journal of Cellular and Molecular Medicine. 17: 1465-74. PMID 24251770 DOI: 10.1111/jcmm.12121  0.72
2013 Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA. The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer. Plos One. 8: e78711. PMID 24194950 DOI: 10.1371/journal.pone.0078711  0.72
2013 Wang JC, Felizardo TC, Au BC, Fowler DH, Dekaban GA, Medin JA. Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways. Virology Journal. 10: 240. PMID 23870437 DOI: 10.1186/1743-422X-10-240  0.72
2013 Felizardo TC, Foley J, Steed K, Dropulic B, Amarnath S, Medin JA, Fowler DH. Harnessing autophagy for cell fate control gene therapy. Autophagy. 9: 1069-79. PMID 23633667 DOI: 10.4161/auto.24639  0.72
2013 Hirayama S, Sato M, Loisel-Meyer S, Matsuda Y, Oishi H, Guan Z, Saito T, Yeung J, Cypel M, Hwang DM, Medin JA, Liu M, Keshavjee S. Lentivirus IL-10 gene therapy down-regulates IL-17 and attenuates mouse orthotopic lung allograft rejection American Journal of Transplantation. 13: 1586-1593. PMID 23601206 DOI: 10.1111/ajt.12230  0.72
2013 Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC. Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity. Brain, Behavior, and Immunity. 30: 103-14. PMID 23369732 DOI: 10.1016/j.bbi.2013.01.079  0.72
2013 Scaife M, Pacienza N, Au BC, Wang JC, Devine S, Scheid E, Lee CJ, Lopez-Perez O, Neschadim A, Fowler DH, Foley R, Medin JA. Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes. Gene Therapy. 20: 24-34. PMID 22241175 DOI: 10.1038/gt.2011.210  0.72
2012 Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA. Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia. Human Gene Therapy. 23: 1280-9. PMID 22998370 DOI: 10.1089/hum.2012.063  0.72
2012 Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T. Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. Molecular & Cellular Proteomics : McP. 11: 1870-84. PMID 22986220 DOI: 10.1074/mcp.M112.017889  0.72
2012 Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA. Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1454-61. PMID 22472949 DOI: 10.1038/mt.2012.64  0.72
2012 Neschadim A, Wang JC, Lavie A, Medin JA. Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer. Cancer Gene Therapy. 19: 320-7. PMID 22388453 DOI: 10.1038/cgt.2012.4  0.72
2012 Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA. Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine. Journal of Proteome Research. 11: 2386-96. PMID 22339264 DOI: 10.1021/pr2011236  0.72
2012 Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA. Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1002-13. PMID 22273576 DOI: 10.1038/mt.2011.298  0.72
2012 Swift BE, Williams BA, Kosaka Y, Wang XH, Medin JA, Viswanathan S, Martinez-Lopez J, Keating A. Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model. Haematologica. 97: 1020-8. PMID 22271890 DOI: 10.3324/haematol.2011.054254  0.72
2012 Berthod F, Symes J, Tremblay N, Medin JA, Auger FA. Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. Journal of Cellular Physiology. 227: 2130-7. PMID 21769871 DOI: 10.1002/jcp.22943  0.72
2011 Amarnath S, Mangus CW, Wang JC, Wei F, He A, Kapoor V, Foley JE, Massey PR, Felizardo TC, Riley JL, Levine BL, June CH, Medin JA, Fowler DH. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Science Translational Medicine. 3: 111ra120. PMID 22133721 DOI: 10.1126/scitranslmed.3003130  0.72
2011 Hirayama S, Sato M, Liu M, Loisel-Meyer S, Yeung JC, Wagnetz D, Cypel M, Zehong G, Medin JA, Keshavjee S. Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways. Human Gene Therapy. 22: 1453-60. PMID 21568692 DOI: 10.1089/hum.2010.225  0.72
2011 Felizardo TC, Wang JCM, McGray RAJ, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA. Differential immune responses mediated by adenovirus-and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model Gene Therapy. 18: 986-995. PMID 21490686 DOI: 10.1038/gt.2011.53  0.72
2011 Tsunooka N, Hirayama S, Medin JA, Liles WC, Keshavjee S, Waddell TK. A novel tissue-engineered approach to problems of the postpneumonectomy space. The Annals of Thoracic Surgery. 91: 880-6. PMID 21353020 DOI: 10.1016/j.athoracsur.2010.11.039  0.72
2011 Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T. Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: pitfalls of mutation analyses in patients with low α-galactosidase A activity. Journal of Cardiology. 57: 345-53. PMID 21333496 DOI: 10.1016/j.jjcc.2010.12.004  0.72
2011 Siegers GM, Dhamko H, Wang XH, Mathieson AM, Kosaka Y, Felizardo TC, Medin JA, Tohda S, Schueler J, Fisch P, Keating A. Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells. Cytotherapy. 13: 753-64. PMID 21314241 DOI: 10.3109/14653249.2011.553595  0.72
2011 Siegers GM, Felizardo TC, Mathieson AM, Kosaka Y, Wang XH, Medin JA, Keating A. Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model. Plos One. 6: e16700. PMID 21304898 DOI: 10.1371/journal.pone.0016700  0.72
2011 Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA. Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. Human Gene Therapy. 22: 679-87. PMID 21280983 DOI: 10.1089/hum.2010.195  0.72
2011 Wang AY, Crome SQ, Jenkins KM, Medin JA, Bramson JL, Levings MK. Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production. Cancer Immunology, Immunotherapy : Cii. 60: 381-8. PMID 21153637 DOI: 10.1007/s00262-010-0948-4  0.72
2011 Lee CJ, Fan X, Guo X, Medin JA. Promoter-specific lentivectors for long-term, cardiac-directed therapy of Fabry disease. Journal of Cardiology. 57: 115-22. PMID 20846825 DOI: 10.1016/j.jjcc.2010.08.003  0.72
2011 Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T. Sequencing and characterization of the porcine α-galactosidase A gene: towards the generation of a porcine model for Fabry disease. Molecular Biology Reports. 38: 3145-52. PMID 20131008 DOI: 10.1007/s11033-010-9985-5  0.72
2011 Moretti A, Jaffray DA, Medin JA. Radiation therapy and cancer treatment: From the basics to combination therapies that ignite immunity Experimental and Applied Immunotherapy. 357-388. DOI: 10.1007/978-1-60761-980-2_17  0.72
2010 Romieu-Mourez R, François M, Abate A, Boivin MN, Birman E, Bailey D, Bramson JL, Forner K, Young YK, Medin JA, Galipeau J. Mesenchymal stromal cells expressing ErbB-2/neu elicit protective antibreast tumor immunity in vivo, which is paradoxically suppressed by IFN-gamma and tumor necrosis factor-alpha priming. Cancer Research. 70: 7742-7. PMID 20924101 DOI: 10.1158/0008-5472.CAN-10-0296  0.72
2010 Likar Y, Zurita J, Dobrenkov K, Shenker L, Cai S, Neschadim A, Medin JA, Sadelain M, Hricak H, Ponomarev V. A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 1395-403. PMID 20810757 DOI: 10.2967/jnumed.109.074344  0.72
2010 Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenaka T, Medin JA. Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice. Molecular Medicine (Cambridge, Mass.). 16: 216-21. PMID 20454522 DOI: 10.2119/molmed.2009.00163  0.72
2010 Drake RR, Elschenbroich S, Lopez-Perez O, Kim Y, Ignatchenko V, Ignatchenko A, Nyalwidhe JO, Basu G, Wilkins CE, Gjurich B, Lance RS, Semmes OJ, Medin JA, Kislinger T. In-depth proteomic analyses of direct expressed prostatic secretions. Journal of Proteome Research. 9: 2109-16. PMID 20334419 DOI: 10.1021/pr1001498  0.72
2010 Fan X, Lang H, Zhou X, Zhang L, Yin R, Maciejko J, Giannitsos V, Motyka B, Medin JA, Platt JL, West LJ. Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction. Human Gene Therapy. 21: 877-890. PMID 20163247  0.72
2010 Elschenbroich S, Kim Y, Medin JA, Kislinger T. Isolation of cell surface proteins for mass spectrometry-based proteomics. Expert Review of Proteomics. 7: 141-54. PMID 20121483 DOI: 10.1586/epr.09.97  0.72
2010 Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. Regulatory Peptides. 159: 44-53. PMID 19778557 DOI: 10.1016/j.regpep.2009.09.007  0.72
2010 Medin JA. Molecular Therapeutics in Hematology: Gene Therapy Molecular Hematology: Third Edition. 318-335. DOI: 10.1002/9781444318531.ch25  0.72
2009 Symes J, Evangelou A, Ignatchenko A, Fleshner N, Kislinger T, Medin JA. Multidimensional protein identification technology analysis highlights mitoxantrone-induced expression modulations in the primary prostate cancer cell proteome. Proteomics. Clinical Applications. 3: 347-58. PMID 26238752 DOI: 10.1002/prca.200800102  0.72
2009 Francia G, Man S, Lee CJ, Lee CR, Xu P, Mossoba ME, Emmenegger U, Medin JA, Kerbel RS. Comparative impact of trastuzumab and cyclophosphamide on HER-2-positive human breast cancer xenografts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6358-66. PMID 19825954 DOI: 10.1158/1078-0432.CCR-09-0931  0.72
2009 Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA. Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection. Journal of Cardiology. 54: 245-54. PMID 19782262 DOI: 10.1016/j.jjcc.2009.05.010  0.72
2009 Maekawa Y, Mizue N, Chan A, Shi Y, Liu Y, Dawood S, Chen M, Dawood F, de Couto G, Li GH, Suzuki N, Yeh WC, Gramolini A, Medin JA, Liu PP. Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells. Circulation. 120: 1401-14. PMID 19770394 DOI: 10.1161/CIRCULATIONAHA.109.865956  0.72
2009 Scaife MD, Neschadim A, Fowler DH, Medin JA. Novel application of lentiviral vectors towards treatment of graft-versus-host disease. Expert Opinion On Biological Therapy. 9: 749-61. PMID 19456209 DOI: 10.1517/14712590903002021  0.72
2009 Loisel-Meyer S, Felizardo T, Mariotti J, Mossoba ME, Foley JE, Kammerer R, Mizue N, Keefe R, McCart JA, Zimmermann W, Dropulic B, Fowler DH, Medin JA. Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection. Molecular Cancer Therapeutics. 8: 692-702. PMID 19276164 DOI: 10.1158/1535-7163.MCT-08-0769  0.72
2009 Symes JC, Siatskas C, Fowler DH, Medin JA. Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells Cancer Gene Therapy. 16: 439-452. PMID 19096446 DOI: 10.1038/cgt.2008.96  0.72
2009 Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA. Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 262-8. PMID 19002160 DOI: 10.1038/mt.2008.244  0.72
2009 Surzyn M, Symes J, Medin JA, Sefton MV. IL-10 secretion increases signal persistence of HEMA-MMA-microencapsulated luciferase-modified CHO fibroblasts in mice. Tissue Engineering. Part A. 15: 127-36. PMID 18710337 DOI: 10.1089/ten.tea.2008.0028  0.72
2009 Rodriguez-Sosa JR, Silvertown JD, Foster RA, Medin JA, Hahnel A. Transduction and transplantation of spermatogonia into the testis of ram lambs through the extra-testicular rete Reproduction in Domestic Animals. 44: 612-620. PMID 18694428 DOI: 10.1111/j.1439-0531.2007.01030.x  0.72
2009 Labbe A, Nelles M, Walia J, Jia L, Furlonger C, Nonaka T, Medin JA, Paige CJ. IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy. Journal of Cellular and Molecular Medicine. 13: 1962-76. PMID 18624776 DOI: 10.1111/j.1582-4934.2008.00412.x  0.72
2008 Francia G, Emmenegger U, Lee CR, Shaked Y, Folkins C, Mossoba M, Medin JA, Man S, Zhu Z, Witte L, Kerbel RS. Long-term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-human choriogonadotropin secreting tumor cell lines. Molecular Cancer Therapeutics. 7: 3452-9. PMID 18852148 DOI: 10.1158/1535-7163.MCT-08-0200  0.72
2008 Ramsubir S, Nonaka T, Girbés CB, Carpentier S, Levade T, Medin JA. In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. Molecular Genetics and Metabolism. 95: 133-41. PMID 18805722 DOI: 10.1016/j.ymgme.2008.08.003  0.72
2008 Symes JC, Kurin M, Fleshner NE, Medin JA. Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel. Molecular Cancer Therapeutics. 7: 3018-28. PMID 18790782 DOI: 10.1158/1535-7163.MCT-08-0335  0.72
2008 Loisel-Meyer S, Foley R, Medin JA. Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials. Frontiers in Bioscience : a Journal and Virtual Library. 13: 3202-14. PMID 18508428 DOI: 10.2741/2921  0.72
2008 Mossoba ME, Walia JS, Rasaiah VI, Buxhoeveden N, Head R, Ying C, Foley JE, Bramson JL, Fowler DH, Medin JA. Tumor protection following vaccination with low doses of lentivirally transduced DCs expressing the self-antigen erbB2 Molecular Therapy. 16: 607-617. PMID 18180774 DOI: 10.1038/  0.72
2008 Rasaiah VI, Underwood JP, Oreopoulos DG, Medin JA. Implementation of high-throughput screening for Fabry disease in Toronto dialysis patients [5] Ndt Plus. 1: 129-130. DOI: 10.1093/ndtplus/sfn009  0.72
2007 Neschadim A, McCart JA, Keating A, Medin JA. A roadmap to safe, efficient, and stable lentivirus-mediated gene therapy with hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 13: 1407-16. PMID 18022569 DOI: 10.1016/j.bbmt.2007.09.014  0.72
2007 Ramsubir S, Yoshimitsu M, Medin JA. Anti-CD25 targeted killing of bicistronically transduced cells: a novel safety mechanism against retroviral genotoxicity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1174-81. PMID 17387334 DOI: 10.1038/  0.72
2007 Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA. Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 962-70. PMID 17375075 DOI: 10.1038/  0.72
2007 Higuchi K, Medin JA. Lentiviral vectors for gene therapy of heart disease. Journal of Cardiology. 49: 1-11. PMID 17269208  0.72
2007 Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L. Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 818-24. PMID 17264854 DOI: 10.1038/  0.72
2007 Liang SB, Yoshimitsu M, Poeppl A, Rasaiah VI, Cai J, Fowler DH, Medin JA. Multiple reduced-intensity conditioning regimens facilitate correction of Fabry mice after transplantation of transduced cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 618-27. PMID 17228315 DOI: 10.1038/  0.72
2007 Silvertown JD, Symes JC, Neschadim A, Nonaka T, Kao JC, Summerlee AJ, Medin JA. Analog of H2 relaxin exhibits antagonistic properties and impairs prostate tumor growth. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 754-65. PMID 17197386 DOI: 10.1096/fj.06-6847com  0.72
2007 Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka T, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA. Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells. Gene Therapy. 14: 256-65. PMID 16929352 DOI: 10.1038/  0.72
2006 Mossoba ME, Medin JA. Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials. Expert Review of Vaccines. 5: 717-32. PMID 17181444 DOI: 10.1586/14760584.5.5.717  0.72
2006 Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA. Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A. Circulation Journal : Official Journal of the Japanese Circulation Society. 70: 1503-8. PMID 17062978 DOI: JST.JSTAGE/circj/70.1503  0.72
2006 Silvertown JD, Walia JS, Summerlee AJ, Medin JA. Functional expression of mouse relaxin and mouse relaxin-3 in the lung from an Ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery. Endocrinology. 147: 3797-808. PMID 16709614 DOI: 10.1210/en.2006-0028  0.72
2006 Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M, Higuchi K, Siatskas C, Lee P, Lim H, Zhang J, Cukerman E, Stanford WL, Medin JA, Liu PP. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 103: 2304-9. PMID 16467148 DOI: 10.1073/pnas.0510997103  0.72
2006 du Manoir JM, Francia G, Man S, Mossoba M, Medin JA, Viloria-Petit A, Hicklin DJ, Emmenegger U, Kerbel RS. Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 904-16. PMID 16467105 DOI: 10.1158/1078-0432.CCR-05-1109  0.72
2006 Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA. H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. International Journal of Cancer. 118: 62-73. PMID 16049981 DOI: 10.1002/ijc.21288  0.72
2005 Lund N, Branch DR, Sakac D, Lingwood CA, Siatskas C, Robinson CJ, Brady RO, Medin JA. Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus. Aids (London, England). 19: 1543-6. PMID 16135910  0.72
2005 Siatskas C, Underwood J, Ramezani A, Hawley RG, Medin JA. Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1752-4. PMID 16076962 DOI: 10.1096/fj.05-4006fje  0.72
2005 Silvertown JD, Walia JS, Medin JA. Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA. Developmental and Comparative Immunology. 29: 989-1002. PMID 15935473 DOI: 10.1016/j.dci.2005.02.007  0.72
2005 Medin JA, Liang SB, Hou JW, Kelley LS, Peace DJ, Fowler DH. Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo. Cancer Gene Therapy. 12: 540-51. PMID 15678150 DOI: 10.1038/sj.cgt.7700810  0.72
2005 Poeppl AG, Murray GJ, Medin JA. Enhanced filter paper enzyme assay for high-throughput population screening for Fabry disease. Analytical Biochemistry. 337: 161-3. PMID 15649390 DOI: 10.1016/j.ab.2004.10.007  0.72
2004 Yoshimitsu M, Sato T, Tao K, Walia JS, Rasaiah VI, Sleep GT, Murray GJ, Poeppl AG, Underwood J, West L, Brady RO, Medin JA. Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 101: 16909-14. PMID 15550536 DOI: 10.1073/pnas.0407572101  0.72
2004 Smith SL, Kiss J, Siatskas C, Medin JA, Moldwin RL. Enhanced effect of vascular endothelial growth factor, thrombopoietin peptide agonist, SCF, and Flt3-L on LTC-IC and reporter gene transduction from umbilical cord blood CD34+ cells. Transfusion. 44: 438-49. PMID 14996204 DOI: 10.1111/j.1537-2995.2003.00661.x  0.72
2003 Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T. The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1144-6. PMID 12692077 DOI: 10.1096/fj.02-1053fje  0.72
2003 Medin JA. Vector divergence to convergence? Gene Therapy. 10: 1407. DOI: 10.1038/  0.72
2002 Medin JA, Fowler DH. Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: beyond efficiency issues. Journal of Cellular Biochemistry. Supplement. 38: 46-54. PMID 12046849  0.72
2002 Medin JA, Fowler DH. Obstacles to human hematopoietic stem cell transduction by recombinant adeno-associated virus 2 vectors Journal of Cellular Biochemistry. 85: 39-45. DOI: 10.1002/jcb.10053  0.72
2001 Sitaskas C, Medin JA. Gene therapy for Fabry disease Journal of Inherited Metabolic Disease. 24: 25-41. PMID 11758676 DOI: 10.1023/A:1012455421014  0.72
2001 Veldman RJ, Maestre N, Aduib OM, Medin JA, Salvayre R, Levade T. A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: Potential implications in tumour necrosis factor signalling Biochemical Journal. 355: 859-868. PMID 11311151  0.72
2001 Qin G, Takenaka T, Telsch K, Kelley L, Howard T, Levade T, Deans R, Howard BH, Malech HL, Brady RO, Medin JA. Preselective gene therapy for Fabry disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 3428-33. PMID 11248095 DOI: 10.1073/pnas.061020598  0.72
2000 Medin JA, Buttrick PM. Gene Transfer in the Cardiovascular System Update 2000 Heart Disease. 2: 409-421. PMID 11728292  0.72
2000 Takenaka T, Murray GJ, Qin G, Quirk JM, Ohshima T, Qasba P, Clark K, Kulkarni AB, Brady RO, Medin JA. Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 7515-20. PMID 10840053 DOI: 10.1073/pnas.120177997  0.72
2000 Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T. Stress-induced apoptosis is not mediated by endolysosomal ceramide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 36-47. PMID 10627278  0.72
1999 Takenaka T, Qin G, Brady RO, Medin JA. Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease. Human Gene Therapy. 10: 1931-9. PMID 10466627 DOI: 10.1089/10430349950017293  0.72
1999 Takenaka T, Hendrickson CS, Tworek DM, Tudor M, Schiffmann R, Brady RO, Medin JA. Enzymatic and functional correction along with long-term enzyme secretion from transduced bone marrow hematopoietic stem/progenitor and stromal cells derived from patients with Fabry disease. Experimental Hematology. 27: 1149-59. PMID 10390190 DOI: 10.1016/S0301-472X(99)00050-8  0.72
1999 Medin JA, Brandt JE, Rozler E, Nelson M, Bartholomew A, Li C, Turian J, Chute J, Chung T, Hoffman R. Ex vivo expansion and genetic marking of primitive human and baboon hematopoietic cells Annals of the New York Academy of Sciences. 872: 233-242. PMID 10372126 DOI: 10.1111/j.1749-6632.1999.tb08468.x  0.72
1999 Medin JA, Takenaka T, Carpentier S, Garcia V, Basile JP, Segui B, Andrieu-Abadie N, Auge N, Salvayre R, Levade T. Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells Human Gene Therapy. 10: 1321-1329. PMID 10365663 DOI: 10.1089/10430349950018003  0.72
1998 Pemrick SM, Abarzúa P, Kratzeisen C, Marks MS, Medin JA, Ozato K, Grippo JF. Characterization of the chimeric retinoic acid receptor RARalpha/VDR. Leukemia. 12: 554-62. PMID 9557614 DOI: 10.1038/sj.leu.2400937  0.72
1997 Medin JA, Karlsson S. Viral vectors for gene therapy of hematopoietic cells Immunotechnology. 3: 3-19. PMID 9154464 DOI: 10.1016/S1380-2933(96)00059-0  0.72
1997 Nuñez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH. Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor Molecular and Cellular Endocrinology. 127: 27-40. PMID 9099898 DOI: 10.1016/S0303-7207(96)03980-9  0.72
1997 Medin JA, Karlsson S. Selection of retrovirally transduced cells to enhance the efficiency of gene therapy Proceedings of the Association of American Physicians. 109: 111-119. PMID 9069579  0.72
1997 Takcnaka T, Hendrickson CS, Tudor M, Schulmann R, Brady RO, Medin JA. Extending metabolic cooperativity in gene transfer for fabry disease: Transduction of patient bone marrow cells leads to intracellular enzymatic correction and secretion Faseb Journal. 11: A1089.  0.72
1996 Medin JA, Tudor M, Simovitch R, Quirk JM, Jacobson S, Murray GJ, Brady RO. Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector. Proceedings of the National Academy of Sciences of the United States of America. 93: 7917-22. PMID 8755577  0.72
1996 Medin JA, Migita M, Pawliuk R, Jacobson S, Amiri M, Kluepfel-Stahl S, Brady RO, Humphries RK, Karlsson S. A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients. Blood. 87: 1754-62. PMID 8634421  0.72
1996 Medin JA, Tudor M, Simovitch R, Quirk JM, Tacobson S, Murray GJ, Brady RO. Gene therapy for fabry disease: Expression, secretion and uptake of a-galactosidase a (α-gal A) driven by a high titer recombinant retroviral vector Faseb Journal. 10: A1152.  0.72
1995 Migita M, Medin JA, Pawliuk R, Jacobson S, Nagle JW, Anderson S, Amiri M, Humphries RK, Karlsson S. Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors Proceedings of the National Academy of Sciences of the United States of America. 92: 12075-12079. PMID 8618847 DOI: 10.1073/pnas.92.26.12075  0.72
1995 Nunez SB, Medin JA, Wang HKK, Ozato K, Wahli W, Segars J. Retinoid X receptor β and peroxisome proliferator-activated receptor activate an estrogen response element Recent Progress in Hormone Research. 50: 409-415. PMID 7740175  0.72
1995 Medin JA, Gathy K, Coleman MS. Expression of foreign proteins in Trichoplusia ni larvae. Methods in Molecular Biology (Clifton, N.J.). 39: 265-75. PMID 7620555 DOI: 10.1385/0-89603-272-8:265  0.72
1995 Schiffmann R, Medin JA, Ward JM, Stahl S, Cottler-Fox M, Karlsson S. Transfer of the human glucocerebrosidase gene into hematopoietic stem cells of nonablated recipients: Successful engraftment and long-term expression of the transgene Blood. 86: 1218-1227. PMID 7620175  0.72
1994 Bovolenta C, Driggers PH, Marks MS, Medin JA, Politis AD, Vogel SN, Levy DE, Sakaguchi K, Appella E, Coligan JE. Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proceedings of the National Academy of Sciences of the United States of America. 91: 5046-50. PMID 8197182 DOI: 10.1073/pnas.91.11.5046  0.72
1994 Lee IJ, Driggers PH, Medin JA, Nikodem VM, Ozato K. Recombinant thyroid hormone receptor and retinoid X receptor stimulate ligand-dependent transcription in vitro Proceedings of the National Academy of Sciences of the United States of America. 91: 1647-1651. PMID 8127860  0.72
1994 Medin JA, Minucci S, Driggers PH, Lee IJ, Ozato K. Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic acid induced activation of the retinoid X receptorβ homodimer Molecular and Cellular Endocrinology. 105: 27-35. PMID 7821715 DOI: 10.1016/0303-7207(94)90032-9  0.72
1993 Segars JH, Nagata T, Bours V, Medin JA, Franzoso G, Blanco JCG, Drew PD, Becker KG, An J, Tang T, Stephany DA, Neel B, Siebenlist U, Ozato K. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50-p65) and retinoic acid receptor β-retinoid X receptor β heterodimers Molecular and Cellular Biology. 13: 6157-6169. PMID 8413217  0.72
1992 Medin JA, Coleman MS. Lack of functional significance of Cys227 and Cys234 in terminal deoxynucleotidyltransferase. The Journal of Biological Chemistry. 267: 5199-201. PMID 1544903  0.72
1990 Medin JA, Hunt L, Gathy K, Evans RK, Coleman MS. Efficient, low-cost protein factories: expression of human adenosine deaminase in baculovirus-infected insect larvae. Proceedings of the National Academy of Sciences of the United States of America. 87: 2760-4. PMID 2181448  0.72
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