Rob Rottapel - Publications

Medical Biophysics University of Toronto, Toronto, ON, Canada 
Immunology, General Biophysics

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Communal L, Medrano M, Sircoulomb F, Paterson J, Köbel M, Rahimi K, Hoskins P, Tu D, Lheureux S, Oza A, Ailles L, Provencher D, Rottapel R, Mes-Masson AM. Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 32514162 DOI: 10.1038/S41379-020-0586-0  1
2020 Fritz JL, Collins O, Saxena P, Buensuceso A, Ramos Valdes Y, Francis KE, Brown KR, Larsen B, Colwill K, Gingras AC, Rottapel R, Shepherd TG. A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids. Cancers. 12. PMID 32429240 DOI: 10.3390/Cancers12051250  1
2020 Wagner MJ, Hsiung MS, Gish GD, Bagshaw RD, Doodnauth SA, Soliman MA, Jørgensen C, Tucholska M, Rottapel R. The Shb scaffold binds the Nck adaptor protein, p120 RasGAP and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2. The Journal of Biological Chemistry. PMID 32060095 DOI: 10.1074/Jbc.Ra119.009276  1
2019 Yeung T, Fung O, Bashkurov M, Khandani A, Subedar O, Wudwud A, Shaw P, Clarke B, Bartlett J, Rottapel R, Kapus A. Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models. Oncotarget. 10: 6691-6712. PMID 31803363 DOI: 10.18632/Oncotarget.27330  1
2019 Kittaka M, Yoshimoto T, Schlosser C, Rottapel R, Kajiya M, Kurihara H, Reichenberger EJ, Ueki Y. Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31613396 DOI: 10.1002/Jbmr.3882  1
2019 Chui MH, Doodnauth SA, Erdmann N, Tiedemann RE, Sircoulomb F, Drapkin R, Shaw P, Rottapel R. Chromosomal instability and mTORC1 activation through PTEN loss contribute to proteotoxic stress in ovarian carcinoma. Cancer Research. PMID 31530568 DOI: 10.1158/0008-5472.Can-18-3029  1
2019 Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandí MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G. Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways. The Journal of Cell Biology. PMID 31420453 DOI: 10.1083/Jcb.201812073  1
2019 Jiang DM, Fyles A, Nguyen LT, Neel BG, Sacher A, Rottapel R, Wang BX, Ohashi PS, Sridhar SS. Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer. Oncotarget. 10: 2947-2958. PMID 31105877 DOI: 10.18632/Oncotarget.26893  1
2019 Krzyzanowski PM, Sircoulomb F, Yousif F, Normand J, La Rose J, E Francis K, Suarez F, Beck T, McPherson JD, Stein LD, Rottapel RK. Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer. Scientific Reports. 9: 3590. PMID 30837567 DOI: 10.1038/s41598-019-39878-9  1
2019 Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, ... ... Rottapel RK, et al. Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. PMID 30835824 DOI: 10.1002/Cncr.32004  1
2018 Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R. Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8 T Cell Expansion and Differentiation. Cell Reports. 24: 1123-1135. PMID 30067970 DOI: 10.1016/J.Celrep.2018.06.075  1
2018 Gebregiworgis T, Marshall CB, Nishikawa T, Radulovich N, Sandi MJ, Fang Z, Rottapel R, Tsao MS, Ikura M. Multiplexed real-time NMR GTPase assay for simultaneous monitoring of multiple GEF activities from human cancer cells and organoids. Journal of the American Chemical Society. PMID 29543440 DOI: 10.1021/Jacs.7B13703  1
2017 Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, ... Rottapel R, et al. MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity. Science Signaling. 10. PMID 29089450 DOI: 10.1126/Scisignal.Aan3286  1
2017 Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, Changoor A, Zhang L, Stajkowski M, Grynpas MD, Bergmann C, ... Rottapel R, et al. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. The Journal of Clinical Investigation. PMID 28581440 DOI: 10.1172/Jci92233  1
2017 Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, ... ... Rottapel R, et al. Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Oncotarget. 27380-27392. PMID 28423708 DOI: 10.18632/Oncotarget.16068  1
2017 Matsumoto Y, Larose J, Kent OA, Lim M, Changoor A, Zhang L, Storozhuk Y, Mao X, Grynpas MD, Cong F, Rottapel R. RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. The Journal of Clinical Investigation. PMID 28287403 DOI: 10.1172/Jci90527  1
2017 Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, ... ... Rottapel R, et al. Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer. Cell Reports. 18: 2343-2358. PMID 28273451 DOI: 10.1016/J.Celrep.2017.02.028  1
2016 Kent OA, Sandí MJ, Burston HE, Brown KR, Rottapel R. An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer. Oncotarget. PMID 27835861 DOI: 10.18632/Oncotarget.13152  1
2016 Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, ... ... Rottapel R, et al. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. The Journal of Clinical Investigation. PMID 27797343 DOI: 10.1172/Jci87802  1
2016 Fine N, Dimitriou ID, Rullo J, Sandí MJ, Petri B, Haitsma J, Ibrahim H, La Rose J, Glogauer M, Kubes P, Cybulsky M, Rottapel R. GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation. The Journal of Cell Biology. 215: 107-119. PMID 27738004 DOI: 10.1083/Jcb.201603109  1
2016 Kent OA, Mendell JT, Rottapel R. Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1. Molecular Cancer Research : McR. 14: 267-77. PMID 26747707 DOI: 10.1158/1541-7786.Mcr-15-0456  1
2015 Prod'Homme V, Boyer L, Dubois N, Mallavialle A, Munro P, Mouska X, Coste I, Rottapel R, Tartare-Deckert S, Deckert M. Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages. The Journal of Clinical Investigation. 125: 1396-400. PMID 25705883 DOI: 10.1172/Jci71081  1
2015 Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). 67: 656-67. PMID 25470448 DOI: 10.1002/Art.38975  1
2014 Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallographica. Section D, Biological Crystallography. 70: 2740-53. PMID 25286857 DOI: 10.1107/S1399004714017660  1
2014 Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M, Rottapel R. Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1. Nature Communications. 5: 4857. PMID 25209408 DOI: 10.1038/Ncomms5857  1
2014 Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, Pereira K, Lobo N, Stewart J, Go C, Ho J, Medrano M, Hyatt E, Yuan J, Lauriault S, ... ... Rottapel R, et al. Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity. Plos One. 9: e105602. PMID 25170899 DOI: 10.1371/Journal.Pone.0105602  1
2014 Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J. Measuring error rates in genomic perturbation screens: gold standards for human functional genomics. Molecular Systems Biology. 10: 733. PMID 24987113 DOI: 10.15252/Msb.20145216  1
2014 Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger EJ, Ueki Y. SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 2618-35. PMID 24916406 DOI: 10.1002/Jbmr.2295  1
2014 Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D, Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel BG, ... ... Rottapel R, et al. The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. Cancer Cell. 25: 181-95. PMID 24525234 DOI: 10.1016/J.Ccr.2014.01.025  1
2014 Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Research. 74: 2119-30. PMID 24487029 DOI: 10.1158/0008-5472.Can-13-2138  1
2013 Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, ... ... Rottapel R, et al. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Molecular Systems Biology. 9: 696. PMID 24104479 DOI: 10.1038/Msb.2013.54  1
2012 Borozan I, Wilson S, Blanchette P, Laflamme P, Watt SN, Krzyzanowski PM, Sircoulomb F, Rottapel R, Branton PE, Ferretti V. CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes. Bmc Bioinformatics. 13: 206. PMID 22901030 DOI: 10.1186/1471-2105-13-206  1
2012 Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R. The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. Journal of Immunology (Baltimore, Md. : 1950). 189: 2138-50. PMID 22815290 DOI: 10.4049/Jimmunol.1103184  1
2012 Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M. Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts. Methods (San Diego, Calif.). 57: 473-85. PMID 22750304 DOI: 10.1016/J.Ymeth.2012.06.014  1
2012 Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, ... ... Rottapel R, et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discovery. 2: 172-89. PMID 22585861 DOI: 10.1158/2159-8290.Cd-11-0224  1
2012 Guerra FM, Gommerman JL, Corfe SA, Paige CJ, Rottapel R. Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. Plos One. 7: e35533. PMID 22545114 DOI: 10.1371/Journal.Pone.0035533  1
2012 Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C, Larose J, Fine N, Ikura M, Rottapel R. Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Molecular Cell. 45: 642-55. PMID 22405273 DOI: 10.1016/J.Molcel.2012.01.027  1
2012 Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C, LaRose J, Fine N, Ikura M, Rottapel R. Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition Molecular Cell. 45: 844. DOI: 10.1016/j.molcel.2012.03.008  1
2011 Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 147: 1340-54. PMID 22153077 DOI: 10.1016/J.Cell.2011.10.046  1
2011 Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La Rose J, Rottapel R. Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell. 147: 1324-39. PMID 22153076 DOI: 10.1016/J.Cell.2011.10.045  1
2011 Corfe SA, Rottapel R, Paige CJ. Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 3499-510. PMID 21873521 DOI: 10.4049/Jimmunol.1100424  1
2011 Levaot N, Simoncic PD, Dimitriou ID, Scotter A, La Rose J, Ng AH, Willett TL, Wang CJ, Janmohamed S, Grynpas M, Reichenberger E, Rottapel R. 3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions. The Journal of Clinical Investigation. 121: 3244-57. PMID 21765218 DOI: 10.1016/J.Bone.2011.03.080  1
2010 Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S. Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. Journal of Immunology (Baltimore, Md. : 1950). 185: 357-66. PMID 20519645 DOI: 10.4049/Jimmunol.1000066  1
2010 Jain P, Coisne C, Enzmann G, Rottapel R, Engelhardt B. Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 184: 7196-206. PMID 20483748 DOI: 10.4049/Jimmunol.0901404  1
2010 GuezGuez A, Prod'homme V, Mouska X, Baudot A, Blin-Wakkach C, Rottapel R, Deckert M. 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. The Journal of Biological Chemistry. 285: 20952-63. PMID 20439986 DOI: 10.1074/Jbc.M109.091124  1
2010 Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 115: 4824-33. PMID 20348394 DOI: 10.1182/Blood-2009-09-243055  1
2010 Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, et al. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle (Georgetown, Tex.). 9: 1143-55. PMID 20237422 DOI: 10.4161/Cc.9.6.11018  1
2010 Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M. Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. The Journal of Biological Chemistry. 285: 5132-6. PMID 20018863 DOI: 10.1074/Jbc.C109.064766  1
2010 Medrano MA, Saiz FS, Rottapel R. High-throughput RNAi screening platforms: A new outlook in target discovery for cancer therapy Bio Tech International. 22: 6-8.  1
2009 Meiri D, Greeve MA, Brunet A, Finan D, Wells CD, LaRose J, Rottapel R. Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. Molecular and Cellular Biology. 29: 5963-73. PMID 19667072 DOI: 10.1128/Mcb.01268-08  1
2009 Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nature Neuroscience. 12: 735-44. PMID 19448628 DOI: 10.1038/Nn.2339  1
2008 Dehlin M, Bokarewa M, Rottapel R, Foster SJ, Magnusson M, Dahlberg LE, Tarkowski A. Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis. Plos One. 3: e3633. PMID 18982072 DOI: 10.1371/Journal.Pone.0003633  1
2008 Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunological Reviews. 224: 265-83. PMID 18759933 DOI: 10.1111/J.1600-065X.2008.00659.X  1
2008 Garçon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K. CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 111: 1464-71. PMID 18006698 DOI: 10.1182/Blood-2007-08-108050  1
2007 Chen G, Dimitriou ID, La Rose J, Ilangumaran S, Yeh WC, Doody G, Turner M, Gommerman J, Rottapel R. The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Molecular and Cellular Biology. 27: 3109-22. PMID 17283041 DOI: 10.1128/Mcb.01014-06  1
2007 Lam QL, Lo CK, Zheng BJ, Ko KH, Osmond DG, Wu GE, Rottapel R, Lu L. Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice. International Immunology. 19: 267-76. PMID 17229817 DOI: 10.1093/Intimm/Dxl143  1
2006 Deckert M, Rottapel R. The adapter 3BP2: how it plugs into leukocyte signaling. Advances in Experimental Medicine and Biology. 584: 107-14. PMID 16802602 DOI: 10.1007/0-387-34132-3_8  1
2006 Ramanathan S, Gagnon J, Leblanc C, Rottapel R, Ilangumaran S. Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 176: 4029-41. PMID 16547238 DOI: 10.4049/Jimmunol.176.7.4029  1
2005 Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Research. 65: 6685-91. PMID 16061649 DOI: 10.1158/0008-5472.Can-04-4223  1
2005 Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, ... ... Rottapel R, et al. Problems with co-funding in Canada. Science (New York, N.Y.). 308: 1867. PMID 15976286 DOI: 10.1126/Science.308.5730.1867B  1
2005 Bakal CJ, Finan D, LaRose J, Wells CD, Gish G, Kulkarni S, DeSepulveda P, Wilde A, Rottapel R. The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 9529-34. PMID 15976019 DOI: 10.1073/Pnas.0504190102  1
2005 Wu LX, La Rose J, Chen L, Neale C, Mak T, Okkenhaug K, Wange R, Rottapel R. CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway. Journal of Immunology (Baltimore, Md. : 1950). 174: 180-94. PMID 15611240 DOI: 10.4049/Jimmunol.174.1.180  1
2005 Ilangumaran S, Rottapel R. Regulation of IFNγ-induced MHC class-II expression by suppressor of cytokine signaling 1 (SOCS1) Modern Aspects of Immunobiology. 16: 35-39.  1
2004 Ilangumaran S, Ramanathan S, Rottapel R. Regulation of the immune system by SOCS family adaptor proteins. Seminars in Immunology. 16: 351-65. PMID 15541651 DOI: 10.1016/J.Smim.2004.08.015  1
2004 Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. The Journal of Experimental Medicine. 200: 1167-77. PMID 15520247 DOI: 10.1084/Jem.20032246  1
2004 Utting O, Sedgmen BJ, Watts TH, Shi X, Rottapel R, Iulianella A, Lohnes D, Veillette A. Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Molecular and Cellular Biology. 24: 6067-75. PMID 15199160 DOI: 10.1128/Mcb.24.13.6067-6075.2004  1
2004 Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. The Journal of Experimental Medicine. 199: 399-410. PMID 14757745 DOI: 10.1084/Jem.20032092  1
2004 Minoo P, Zadeh MM, Rottapel R, Lebrun JJ, Ali S. A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. Blood. 103: 1398-407. PMID 14551136 DOI: 10.1182/Blood-2003-07-2617  1
2003 Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Molecular Cell. 12: 1413-26. PMID 14690596 DOI: 10.1016/S1097-2765(03)00490-8  1
2003 Ilangumaran S, Finan D, Rottapel R. Flow cytometric analysis of cytokine receptor signal transduction. Journal of Immunological Methods. 278: 221-34. PMID 12957410 DOI: 10.1016/S0022-1759(03)00177-7  1
2003 Ilangumaran S, Ramanathan S, La Rose J, Poussier P, Rottapel R. Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 171: 2435-45. PMID 12928391 DOI: 10.4049/Jimmunol.171.5.2435  1
2003 Ilangumaran S, Finan D, Raine J, Rottapel R. Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease. The Journal of Biological Chemistry. 278: 41871-80. PMID 12917417 DOI: 10.1074/Jbc.M308382200  1
2003 Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P, Rottapel R. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood. 102: 4115-22. PMID 12907450 DOI: 10.1182/Blood-2003-01-0175  1
2003 Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. The Journal of Biological Chemistry. 278: 38495-504. PMID 12881521 DOI: 10.1074/Jbc.M305656200  1
2003 Casteran N, De Sepulveda P, Beslu N, Aoubala M, Letard S, Lecocq E, Rottapel R, Dubreuil P. Signal transduction by several KIT juxtamembrane domain mutations. Oncogene. 22: 4710-22. PMID 12879016 DOI: 10.1038/Sj.Onc.1206587  1
2003 Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18: 763-75. PMID 12818158 DOI: 10.1016/S1074-7613(03)00148-1  1
2003 Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Molecular and Cellular Biology. 23: 3067-78. PMID 12697809 DOI: 10.1128/Mcb.23.9.3067-3078.2003  1
2003 Ilangumaran S, Rottapel R. Regulation of cytokine receptor signaling by SOCS1. Immunological Reviews. 192: 196-211. PMID 12670405 DOI: 10.1034/J.1600-065X.2003.00020.X  1
2002 Ilangumaran S, Finan D, La Rose J, Raine J, Silverstein A, De Sepulveda P, Rottapel R. A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts. Journal of Immunology (Baltimore, Md. : 1950). 169: 5010-20. PMID 12391216 DOI: 10.4049/Jimmunol.169.9.5010  1
2002 Haq R, Brenton JD, Takahashi M, Finan D, Finkielsztein A, Damaraju S, Rottapel R, Zanke B. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Research. 62: 5076-82. PMID 12208764  1
2002 Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. The Journal of Experimental Medicine. 196: 335-48. PMID 12163562 DOI: 10.1084/Jem.20020307  1
2002 Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P. The tumor suppressor activity of SOCS-1. Oncogene. 21: 4351-62. PMID 12080466 DOI: 10.1038/Sj.Onc.1205537  1
2001 Rottapel R. Putting the brakes on arthritis: Can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis? Journal of Clinical Investigation. 108: 1745-1747. PMID 11748257 DOI: 10.1172/Jci14661  1
2001 Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G. Suppressor of Cytokine Signaling 1 Interacts with the Macrophage Colony-stimulating Factor Receptor and Negatively Regulates Its Proliferation Signal Journal of Biological Chemistry. 276: 22133-22139. PMID 11297560 DOI: 10.1074/Jbc.M101878200  1
2001 Trop S, De Sepulveda P, Zúñiga-Pflücker JC, Rottapel R. Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes Blood. 97: 2269-2277. PMID 11290587 DOI: 10.1182/Blood.V97.8.2269  1
2001 Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi PS, Rottapel R. A point mutation in CD28 distinguishes proliferative signals from survival signals Nature Immunology. 2: 325-332. PMID 11276203 DOI: 10.1038/86327  1
2000 De Sepulveda P, Ilangumaran S, Rottapel R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation Journal of Biological Chemistry. 275: 14005-14008. PMID 10747851 DOI: 10.1074/Jbc.C000106200  1
1999 Tyers M, Rottapel R. VHL: A very hip ligase Proceedings of the National Academy of Sciences of the United States of America. 96: 12230-12232. PMID 10535903 DOI: 10.1073/Pnas.96.22.12230  1
1999 Leung BL, Haughn L, Veillette A, Hawley RG, Rottapel R, Julius M. TCRαβ-independent CD28 signaling and costimulation require non-CD4- associated Lck Journal of Immunology. 163: 1334-1341. PMID 10415032  1
1999 De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. The Embo Journal. 18: 904-15. PMID 10022833 DOI: 10.1093/Emboj/18.4.904  1
1998 Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation Immunity. 9: 595-605. PMID 9846481 DOI: 10.1016/S1074-7613(00)80657-3  1
1998 Okkenhaug K, Rottapel R. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction Journal of Biological Chemistry. 273: 21194-21202. PMID 9694876 DOI: 10.1074/Jbc.273.33.21194  1
1998 Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Molecular and Cellular Biology. 18: 2089-99. PMID 9528781 DOI: 10.1128/Mcb.18.4.2089  1
1997 Gommerman JL, Rottapel R, Berger SA. Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand- stimulated internalization of the c-Kit receptor Journal of Biological Chemistry. 272: 30519-30525. PMID 9374546 DOI: 10.1074/Jbc.272.48.30519  1
1997 Marengère LEM, Okkenhaug K, Clavreul A, Couez D, Gibson S, Mills GB, Mak TW, Rottapel R. The SH3 Domain of Itk/Emt Binds to Proline-Rich Sequences in the Cytoplasmic Domain of the T Cell Costimulatory Receptor CD28 Journal of Immunology. 159: 3220-3229. PMID 9317120  1
1996 Ray RJ, Paige CJ, Furlonger C, Lyman SD, Rottapel R. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7 European Journal of Immunology. 26: 1504-1510. PMID 8766553 DOI: 10.1002/Eji.1830260715  1
1996 Beslu N, LaRose J, Casteran N, Birnbaum D, Lecocq E, Dubreuil P, Rottapel R. Phosphatidylinositol-3′ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase Journal of Biological Chemistry. 271: 20075-20081. PMID 8702727 DOI: 10.1074/Jbc.271.33.20075  1
1996 Rosnet O, Bühring HJ, DeLapeyrière O, Beslu N, Lavagna C, Marchetto S, Rappold I, Drexler HG, Birg F, Rottapel R, Hannum C, Dubreuil P, Birnbaum D. Expression and signal transduction of the FLT3 tyrosine kinase receptor Acta Haematologica. 95: 218-223. PMID 8677746 DOI: 10.1007/978-1-4613-0391-6_44  1
1996 Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP. Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase Journal of Biological Chemistry. 271: 12956-12963. PMID 8662748 DOI: 10.1074/Jbc.271.22.12956  1
1996 Okkenhaug K, Rottapel R. SH3 mediated association between CD28 and GRB2 Faseb Journal. 10.  1
1996 Ray RJ, Furlonger C, Rottapel R, Paige CJ. FLT3 ligand supports the differentiation of early B cell progenitors in the presence of IL-11 and IL-7 Faseb Journal. 10.  1
1995 Borg JP, DeLapeyriere O, Noguchi T, Rottapel R, Dubreuil P, Birnbaum D. Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase Oncogene. 10: 973-984. PMID 7898938  1
1995 DeLapeyriere O, Naquet P, Planche J, Marchetto S, Rottapel R, Gambarelli D, Rosnet O, Birnbaum D. Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues Differentiation. 58: 351-359. PMID 7622010 DOI: 10.1046/J.1432-0436.1995.5850351.X  1
1994 Rottapel R, Turck CW, Casteran N, Liu X, Birnbaum D, Pawson T, Dubreuil P. Substrate specificities and identification of a putative binding site for P13K in the carboxy tail of the murine Flt3 receptor tyrosine kinase Oncogene. 9: 1755-1765. PMID 8183574  1
1994 Pagès F, Ragueneau M, Rottapel R, Truneh A, Nunes J, Imbert J, Olive D. Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling Nature. 369: 327-329. PMID 8183372 DOI: 10.1038/369327A0  1
1994 Casteran N, Rottapel R, Beslu N, Lecocq E, Birnbaum D, Dubreuil P. Analysis of the mitogenic pathway of the FLT3 receptor and characterization in its C terminal region of a specific binding site for the PI3' kinase Cellular and Molecular Biology. 40: 443-456. PMID 7920189  1
1993 Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D. The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor Oncogene. 8: 1233-1240. PMID 8386825  1
1993 Maroc N, Rottapel R, Rosnet O, Marchetto S, Lavezzi C, Mannoni P, Birnbaum D, Dubreuil P. Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase Oncogene. 8: 909-918. PMID 8384358  1
1992 Rottapel R. The fascinating story of a longstanding puzzle revealed or what we can learn from a mouse Journal of Rheumatology. 19: 1498-1501. PMID 1464858  1
1992 Meininger CJ, Yano H, Rottapel R, Bernstein A, Zsebo KM, Zetter BR. The c-kit receptor ligand functions as a mast cell chemoattractant Blood. 79: 958-963. PMID 1371080 DOI: 10.1182/Blood.V79.4.958.958  1
1991 Dubreuil P, Forrester L, Rottapel R, Reedijk M, Fujita J, Bernstein A. The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice. Proceedings of the National Academy of Sciences of the United States of America. 88: 2341-5. PMID 1826051 DOI: 10.1073/Pnas.88.6.2341  1
1991 Bernstein A, Forrester L, Reith AD, Dubreuil P, Rottapel R. The murine W/c-kit and Steel loci and the control of hematopoiesis. Seminars in Hematology. 28: 138-42. PMID 1715096  1
1991 Rottapel R, Reedijk M, Williams DE, Lyman SD, Anderson DM, Pawson T, Bernstein A. The Steel/W Transduction Pathway: Kit Autophosphorylation and Its Association with a Unique Subset of Cytoplasmic Signaling Proteins Is Induced by the Steel Factor Molecular and Cellular Biology. 11: 3043-3051. PMID 1710023 DOI: 10.1128/Mcb.11.6.3043  1
1990 Dubreuil P, Rottapel R, Reith AD, Forrester L, Bernstein A. The mouse W/c-kit locus. A mammalian gene that controls the development of three distinct cell lineages. Annals of the New York Academy of Sciences. 599: 58-65. PMID 1699461 DOI: 10.1111/J.1749-6632.1990.Tb42364.X  1
1990 Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes & Development. 4: 390-400. PMID 1692559 DOI: 10.1101/Gad.4.3.390  1
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