| Year |
Citation |
Score |
| 2020 |
Kent OA, Saha M, Coyaud E, Burston HE, Law N, Dadson K, Chen S, Laurent EM, St-Germain J, Sun RX, Matsumoto Y, Cowen J, Montgomery-Song A, Brown KR, Ishak C, ... Rottapel R, et al. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Nature Communications. 11: 4673. PMID 32938917 DOI: 10.1038/S41467-020-18483-9 |
0.776 |
|
| 2020 |
Preuss F, Chatterjee D, Mathea S, Shrestha S, St-Germain J, Saha M, Kannan N, Raught B, Rottapel R, Knapp S. Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4. Structure (London, England : 1993). PMID 32814032 DOI: 10.1016/J.Str.2020.07.016 |
0.58 |
|
| 2020 |
Douanne T, Chapelier S, Rottapel R, Gavard J, Bidère N. The LUBAC participates in lysophosphatidic acid-induced NF-κB activation. Cellular Immunology. 353: 104133. PMID 32450431 DOI: 10.1016/J.Cellimm.2020.104133 |
0.361 |
|
| 2020 |
Fritz JL, Collins O, Saxena P, Buensuceso A, Ramos Valdes Y, Francis KE, Brown KR, Larsen B, Colwill K, Gingras AC, Rottapel R, Shepherd TG. A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids. Cancers. 12. PMID 32429240 DOI: 10.3390/Cancers12051250 |
0.392 |
|
| 2020 |
Wagner MJ, Hsiung MS, Gish GD, Bagshaw RD, Doodnauth SA, Soliman MA, Jørgensen C, Tucholska M, Rottapel R. The Shb scaffold binds the Nck adaptor protein, p120 RasGAP and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2. The Journal of Biological Chemistry. PMID 32060095 DOI: 10.1074/Jbc.Ra119.009276 |
0.399 |
|
| 2020 |
Matsumoto Y, Rottapel R. Bone dynamics and inflammation: lessons from rare diseases. Immunological Medicine. 1-4. PMID 31999934 DOI: 10.1080/25785826.2020.1720104 |
0.651 |
|
| 2019 |
Yeung T, Fung O, Bashkurov M, Khandani A, Subedar O, Wudwud A, Shaw P, Clarke B, Bartlett J, Rottapel R, Kapus A. Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models. Oncotarget. 10: 6691-6712. PMID 31803363 DOI: 10.18632/Oncotarget.27330 |
0.303 |
|
| 2019 |
Kittaka M, Yoshimoto T, Schlosser C, Rottapel R, Kajiya M, Kurihara H, Reichenberger EJ, Ueki Y. Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31613396 DOI: 10.1002/Jbmr.3882 |
0.323 |
|
| 2019 |
Chui MH, Doodnauth SA, Erdmann N, Tiedemann RE, Sircoulomb F, Drapkin R, Shaw P, Rottapel R. Chromosomal instability and mTORC1 activation through PTEN loss contribute to proteotoxic stress in ovarian carcinoma. Cancer Research. PMID 31530568 DOI: 10.1158/0008-5472.Can-18-3029 |
0.326 |
|
| 2019 |
Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandí MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G. Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways. The Journal of Cell Biology. PMID 31420453 DOI: 10.1083/Jcb.201812073 |
0.315 |
|
| 2019 |
Krzyzanowski PM, Sircoulomb F, Yousif F, Normand J, La Rose J, E Francis K, Suarez F, Beck T, McPherson JD, Stein LD, Rottapel RK. Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer. Scientific Reports. 9: 3590. PMID 30837567 DOI: 10.1038/s41598-019-39878-9 |
0.72 |
|
| 2018 |
Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R. Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8 T Cell Expansion and Differentiation. Cell Reports. 24: 1123-1135. PMID 30067970 DOI: 10.1016/J.Celrep.2018.06.075 |
0.391 |
|
| 2018 |
Gebregiworgis T, Marshall CB, Nishikawa T, Radulovich N, Sandi MJ, Fang Z, Rottapel R, Tsao MS, Ikura M. Multiplexed real-time NMR GTPase assay for simultaneous monitoring of multiple GEF activities from human cancer cells and organoids. Journal of the American Chemical Society. PMID 29543440 DOI: 10.1021/Jacs.7B13703 |
0.365 |
|
| 2018 |
Francis K, Burston H, Mokady D, Wagner M, Medrano M, Rottapel R. Abstract IA27: Functional genetic architecture of serous ovarian cancer Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Ovca17-Ia27 |
0.313 |
|
| 2017 |
Fine N, Dimitriou ID, Rottapel R. Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils. Small Gtpases. 11: 23-31. PMID 29188751 DOI: 10.1080/21541248.2017.1332505 |
0.595 |
|
| 2017 |
Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R, et al. MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity. Science Signaling. 10. PMID 29089450 DOI: 10.1126/Scisignal.Aan3286 |
0.793 |
|
| 2017 |
Kent OA, Sandi MJ, Rottapel R. Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition. Small Gtpases. 10: 441-448. PMID 28656876 DOI: 10.1080/21541248.2017.1337545 |
0.74 |
|
| 2017 |
Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, Changoor A, Zhang L, Stajkowski M, Grynpas MD, Bergmann C, Rottapel R, et al. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. The Journal of Clinical Investigation. PMID 28581440 DOI: 10.1172/Jci92233 |
0.782 |
|
| 2017 |
Matsumoto Y, Larose J, Kent OA, Lim M, Changoor A, Zhang L, Storozhuk Y, Mao X, Grynpas MD, Cong F, Rottapel R. RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. The Journal of Clinical Investigation. PMID 28287403 DOI: 10.1172/Jci90527 |
0.791 |
|
| 2017 |
Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, ... Rottapel R, et al. Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer. Cell Reports. 18: 2343-2358. PMID 28273451 DOI: 10.1016/J.Celrep.2017.02.028 |
0.626 |
|
| 2017 |
Azoitei ML, Noh J, Sandi MJ, Roudot P, Rottapel R, Danuser G, Hahn KM. Novel Biosensor Design Reveals the Role and Regulation of GEF-H1 in Cell Migration Biophysical Journal. 112: 461a. DOI: 10.1016/J.Bpj.2016.11.2471 |
0.321 |
|
| 2016 |
Kent OA, Sandí MJ, Burston HE, Brown KR, Rottapel R. An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer. Oncotarget. PMID 27835861 DOI: 10.18632/Oncotarget.13152 |
0.734 |
|
| 2016 |
Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, ... Rottapel R, et al. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. The Journal of Clinical Investigation. PMID 27797343 DOI: 10.1172/Jci87802 |
0.772 |
|
| 2016 |
Fine N, Dimitriou ID, Rullo J, Sandí MJ, Petri B, Haitsma J, Ibrahim H, La Rose J, Glogauer M, Kubes P, Cybulsky M, Rottapel R. GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation. The Journal of Cell Biology. 215: 107-119. PMID 27738004 DOI: 10.1083/Jcb.201603109 |
0.753 |
|
| 2016 |
Kent OA, Mendell JT, Rottapel R. Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1. Molecular Cancer Research : McR. 14: 267-77. PMID 26747707 DOI: 10.1158/1541-7786.Mcr-15-0456 |
0.7 |
|
| 2015 |
Prod'Homme V, Boyer L, Dubois N, Mallavialle A, Munro P, Mouska X, Coste I, Rottapel R, Tartare-Deckert S, Deckert M. Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages. The Journal of Clinical Investigation. 125: 1396-400. PMID 25705883 DOI: 10.1172/Jci71081 |
0.367 |
|
| 2015 |
Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). 67: 656-67. PMID 25470448 DOI: 10.1002/Art.38975 |
0.355 |
|
| 2014 |
Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M, Rottapel R. Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1. Nature Communications. 5: 4857. PMID 25209408 DOI: 10.1038/Ncomms5857 |
0.316 |
|
| 2014 |
Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger EJ, Ueki Y. SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 2618-35. PMID 24916406 DOI: 10.1002/Jbmr.2295 |
0.346 |
|
| 2014 |
Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D, Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel BG, ... Rottapel R, et al. The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. Cancer Cell. 25: 181-95. PMID 24525234 DOI: 10.1016/J.Ccr.2014.01.025 |
0.785 |
|
| 2014 |
Cullis J, Meiri D, Jose-Sandi M, Kent O, Medrano M, Mokady D, Tsao M, Gingras A, Rottapel R. Abstract B31: The RhoGEF GEF-H1 is required for RAS oncogene-driven pancreatic cancer Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B31 |
0.342 |
|
| 2014 |
Vargas MJS, Kent OA, Normand J, Rottapel R. Abstract A20: ARHGEF2 inhibition impairs cell growth and viability in KRAS-dependent cancer cells Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-A20 |
0.312 |
|
| 2012 |
Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R. The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. Journal of Immunology (Baltimore, Md. : 1950). 189: 2138-50. PMID 22815290 DOI: 10.4049/Jimmunol.1103184 |
0.654 |
|
| 2012 |
Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M. Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts. Methods (San Diego, Calif.). 57: 473-85. PMID 22750304 DOI: 10.1016/J.Ymeth.2012.06.014 |
0.339 |
|
| 2012 |
Guerra FM, Gommerman JL, Corfe SA, Paige CJ, Rottapel R. Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. Plos One. 7: e35533. PMID 22545114 DOI: 10.1371/Journal.Pone.0035533 |
0.783 |
|
| 2012 |
Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C, Larose J, Fine N, Ikura M, Rottapel R. Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Molecular Cell. 45: 642-55. PMID 22405273 DOI: 10.1016/J.Molcel.2012.01.027 |
0.726 |
|
| 2011 |
Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La Rose J, Rottapel R. Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell. 147: 1324-39. PMID 22153076 DOI: 10.1016/J.Cell.2011.10.045 |
0.752 |
|
| 2011 |
Corfe SA, Rottapel R, Paige CJ. Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 3499-510. PMID 21873521 DOI: 10.4049/Jimmunol.1100424 |
0.353 |
|
| 2011 |
Levaot N, Simoncic PD, Dimitriou ID, Scotter A, La Rose J, Ng AH, Willett TL, Wang CJ, Janmohamed S, Grynpas M, Reichenberger E, Rottapel R. 3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions. The Journal of Clinical Investigation. 121: 3244-57. PMID 21765218 DOI: 10.1016/J.Bone.2011.03.080 |
0.751 |
|
| 2010 |
Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S. Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. Journal of Immunology (Baltimore, Md. : 1950). 185: 357-66. PMID 20519645 DOI: 10.4049/Jimmunol.1000066 |
0.687 |
|
| 2010 |
GuezGuez A, Prod'homme V, Mouska X, Baudot A, Blin-Wakkach C, Rottapel R, Deckert M. 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. The Journal of Biological Chemistry. 285: 20952-63. PMID 20439986 DOI: 10.1074/Jbc.M109.091124 |
0.46 |
|
| 2010 |
Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 115: 4824-33. PMID 20348394 DOI: 10.1182/Blood-2009-09-243055 |
0.608 |
|
| 2010 |
Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, et al. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle (Georgetown, Tex.). 9: 1143-55. PMID 20237422 DOI: 10.4161/Cc.9.6.11018 |
0.375 |
|
| 2010 |
Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M. Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. The Journal of Biological Chemistry. 285: 5132-6. PMID 20018863 DOI: 10.1074/Jbc.C109.064766 |
0.3 |
|
| 2009 |
Meiri D, Greeve MA, Brunet A, Finan D, Wells CD, LaRose J, Rottapel R. Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. Molecular and Cellular Biology. 29: 5963-73. PMID 19667072 DOI: 10.1128/Mcb.01268-08 |
0.37 |
|
| 2009 |
Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nature Neuroscience. 12: 735-44. PMID 19448628 DOI: 10.1038/Nn.2339 |
0.318 |
|
| 2008 |
Dehlin M, Bokarewa M, Rottapel R, Foster SJ, Magnusson M, Dahlberg LE, Tarkowski A. Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis. Plos One. 3: e3633. PMID 18982072 DOI: 10.1371/Journal.Pone.0003633 |
0.342 |
|
| 2008 |
Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunological Reviews. 224: 265-83. PMID 18759933 DOI: 10.1111/J.1600-065X.2008.00659.X |
0.606 |
|
| 2008 |
Garçon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K. CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 111: 1464-71. PMID 18006698 DOI: 10.1182/Blood-2007-08-108050 |
0.384 |
|
| 2007 |
Chen G, Dimitriou ID, La Rose J, Ilangumaran S, Yeh WC, Doody G, Turner M, Gommerman J, Rottapel R. The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Molecular and Cellular Biology. 27: 3109-22. PMID 17283041 DOI: 10.1128/Mcb.01014-06 |
0.788 |
|
| 2007 |
Lam QL, Lo CK, Zheng BJ, Ko KH, Osmond DG, Wu GE, Rottapel R, Lu L. Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice. International Immunology. 19: 267-76. PMID 17229817 DOI: 10.1093/Intimm/Dxl143 |
0.328 |
|
| 2006 |
Deckert M, Rottapel R. The adapter 3BP2: how it plugs into leukocyte signaling. Advances in Experimental Medicine and Biology. 584: 107-14. PMID 16802602 DOI: 10.1007/0-387-34132-3_8 |
0.417 |
|
| 2006 |
Ramanathan S, Gagnon J, Leblanc C, Rottapel R, Ilangumaran S. Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 176: 4029-41. PMID 16547238 DOI: 10.4049/Jimmunol.176.7.4029 |
0.662 |
|
| 2005 |
Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Research. 65: 6685-91. PMID 16061649 DOI: 10.1158/0008-5472.Can-04-4223 |
0.646 |
|
| 2005 |
Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, ... ... Rottapel R, et al. Problems with co-funding in Canada. Science (New York, N.Y.). 308: 1867. PMID 15976286 DOI: 10.1126/Science.308.5730.1867B |
0.498 |
|
| 2005 |
Bakal CJ, Finan D, LaRose J, Wells CD, Gish G, Kulkarni S, DeSepulveda P, Wilde A, Rottapel R. The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 9529-34. PMID 15976019 DOI: 10.1073/Pnas.0504190102 |
0.662 |
|
| 2005 |
Wu LX, La Rose J, Chen L, Neale C, Mak T, Okkenhaug K, Wange R, Rottapel R. CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway. Journal of Immunology (Baltimore, Md. : 1950). 174: 180-94. PMID 15611240 DOI: 10.4049/Jimmunol.174.1.180 |
0.755 |
|
| 2004 |
Ilangumaran S, Ramanathan S, Rottapel R. Regulation of the immune system by SOCS family adaptor proteins. Seminars in Immunology. 16: 351-65. PMID 15541651 DOI: 10.1016/J.Smim.2004.08.015 |
0.695 |
|
| 2004 |
Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. The Journal of Experimental Medicine. 200: 1167-77. PMID 15520247 DOI: 10.1084/Jem.20032246 |
0.67 |
|
| 2004 |
Utting O, Sedgmen BJ, Watts TH, Shi X, Rottapel R, Iulianella A, Lohnes D, Veillette A. Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Molecular and Cellular Biology. 24: 6067-75. PMID 15199160 DOI: 10.1128/Mcb.24.13.6067-6075.2004 |
0.4 |
|
| 2004 |
Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. The Journal of Experimental Medicine. 199: 399-410. PMID 14757745 DOI: 10.1084/Jem.20032092 |
0.68 |
|
| 2004 |
Minoo P, Zadeh MM, Rottapel R, Lebrun JJ, Ali S. A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. Blood. 103: 1398-407. PMID 14551136 DOI: 10.1182/Blood-2003-07-2617 |
0.435 |
|
| 2003 |
Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Molecular Cell. 12: 1413-26. PMID 14690596 DOI: 10.1016/S1097-2765(03)00490-8 |
0.363 |
|
| 2003 |
Ilangumaran S, Finan D, Rottapel R. Flow cytometric analysis of cytokine receptor signal transduction. Journal of Immunological Methods. 278: 221-34. PMID 12957410 DOI: 10.1016/S0022-1759(03)00177-7 |
0.697 |
|
| 2003 |
Ilangumaran S, Ramanathan S, La Rose J, Poussier P, Rottapel R. Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 171: 2435-45. PMID 12928391 DOI: 10.4049/Jimmunol.171.5.2435 |
0.8 |
|
| 2003 |
Ilangumaran S, Finan D, Raine J, Rottapel R. Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease. The Journal of Biological Chemistry. 278: 41871-80. PMID 12917417 DOI: 10.1074/Jbc.M308382200 |
0.708 |
|
| 2003 |
Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P, Rottapel R. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood. 102: 4115-22. PMID 12907450 DOI: 10.1182/Blood-2003-01-0175 |
0.719 |
|
| 2003 |
Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. The Journal of Biological Chemistry. 278: 38495-504. PMID 12881521 DOI: 10.1074/Jbc.M305656200 |
0.435 |
|
| 2003 |
Casteran N, De Sepulveda P, Beslu N, Aoubala M, Letard S, Lecocq E, Rottapel R, Dubreuil P. Signal transduction by several KIT juxtamembrane domain mutations. Oncogene. 22: 4710-22. PMID 12879016 DOI: 10.1038/Sj.Onc.1206587 |
0.615 |
|
| 2003 |
Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18: 763-75. PMID 12818158 DOI: 10.1016/S1074-7613(03)00148-1 |
0.66 |
|
| 2003 |
Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Molecular and Cellular Biology. 23: 3067-78. PMID 12697809 DOI: 10.1128/Mcb.23.9.3067-3078.2003 |
0.782 |
|
| 2003 |
Ilangumaran S, Rottapel R. Regulation of cytokine receptor signaling by SOCS1. Immunological Reviews. 192: 196-211. PMID 12670405 DOI: 10.1034/J.1600-065X.2003.00020.X |
0.702 |
|
| 2002 |
Ilangumaran S, Finan D, La Rose J, Raine J, Silverstein A, De Sepulveda P, Rottapel R. A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts. Journal of Immunology (Baltimore, Md. : 1950). 169: 5010-20. PMID 12391216 DOI: 10.4049/Jimmunol.169.9.5010 |
0.788 |
|
| 2002 |
Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. The Journal of Experimental Medicine. 196: 335-48. PMID 12163562 DOI: 10.1084/Jem.20020307 |
0.431 |
|
| 2002 |
Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P. The tumor suppressor activity of SOCS-1. Oncogene. 21: 4351-62. PMID 12080466 DOI: 10.1038/Sj.Onc.1205537 |
0.798 |
|
| 2001 |
Rottapel R. Putting the brakes on arthritis: Can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis? Journal of Clinical Investigation. 108: 1745-1747. PMID 11748257 DOI: 10.1172/Jci14661 |
0.437 |
|
| 2001 |
Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G. Suppressor of Cytokine Signaling 1 Interacts with the Macrophage Colony-stimulating Factor Receptor and Negatively Regulates Its Proliferation Signal Journal of Biological Chemistry. 276: 22133-22139. PMID 11297560 DOI: 10.1074/Jbc.M101878200 |
0.602 |
|
| 2001 |
Trop S, De Sepulveda P, Zúñiga-Pflücker JC, Rottapel R. Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes Blood. 97: 2269-2277. PMID 11290587 DOI: 10.1182/Blood.V97.8.2269 |
0.418 |
|
| 2001 |
Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi PS, Rottapel R. A point mutation in CD28 distinguishes proliferative signals from survival signals Nature Immunology. 2: 325-332. PMID 11276203 DOI: 10.1038/86327 |
0.404 |
|
| 2000 |
De Sepulveda P, Ilangumaran S, Rottapel R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation Journal of Biological Chemistry. 275: 14005-14008. PMID 10747851 DOI: 10.1074/Jbc.C000106200 |
0.403 |
|
| 1999 |
Tyers M, Rottapel R. VHL: A very hip ligase Proceedings of the National Academy of Sciences of the United States of America. 96: 12230-12232. PMID 10535903 DOI: 10.1073/Pnas.96.22.12230 |
0.309 |
|
| 1999 |
De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. The Embo Journal. 18: 904-15. PMID 10022833 DOI: 10.1093/Emboj/18.4.904 |
0.652 |
|
| 1998 |
Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation Immunity. 9: 595-605. PMID 9846481 DOI: 10.1016/S1074-7613(00)80657-3 |
0.44 |
|
| 1998 |
Okkenhaug K, Rottapel R. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction Journal of Biological Chemistry. 273: 21194-21202. PMID 9694876 DOI: 10.1074/Jbc.273.33.21194 |
0.378 |
|
| 1998 |
Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Molecular and Cellular Biology. 18: 2089-99. PMID 9528781 DOI: 10.1128/Mcb.18.4.2089 |
0.344 |
|
| 1997 |
Gommerman JL, Rottapel R, Berger SA. Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand- stimulated internalization of the c-Kit receptor Journal of Biological Chemistry. 272: 30519-30525. PMID 9374546 DOI: 10.1074/Jbc.272.48.30519 |
0.707 |
|
| 1996 |
Ray RJ, Paige CJ, Furlonger C, Lyman SD, Rottapel R. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7 European Journal of Immunology. 26: 1504-1510. PMID 8766553 DOI: 10.1002/Eji.1830260715 |
0.339 |
|
| 1996 |
Beslu N, LaRose J, Casteran N, Birnbaum D, Lecocq E, Dubreuil P, Rottapel R. Phosphatidylinositol-3′ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase Journal of Biological Chemistry. 271: 20075-20081. PMID 8702727 DOI: 10.1074/Jbc.271.33.20075 |
0.616 |
|
| 1996 |
Rosnet O, Bühring HJ, DeLapeyrière O, Beslu N, Lavagna C, Marchetto S, Rappold I, Drexler HG, Birg F, Rottapel R, Hannum C, Dubreuil P, Birnbaum D. Expression and signal transduction of the FLT3 tyrosine kinase receptor Acta Haematologica. 95: 218-223. PMID 8677746 DOI: 10.1007/978-1-4613-0391-6_44 |
0.621 |
|
| 1996 |
Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP. Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase Journal of Biological Chemistry. 271: 12956-12963. PMID 8662748 DOI: 10.1074/Jbc.271.22.12956 |
0.367 |
|
| 1996 |
Abraham NG, Champlin R, Giralt S, Gajewski J, Lemoli RM, Fortuna A, Fogli M, Bassan R, Lerede T, Rambaldi A, Barbui T, Gaidano G, Pastore C, Gloghini A, Volpe G, ... ... Rottapel R, et al. Subject Index Vol. 95, 1996 Acta Haematologica. 95: 277-278. DOI: 10.1159/000203898 |
0.479 |
|
| 1996 |
Abraham NG, Champlin R, Giralt S, Gajewski J, Lemoli RM, Fortuna A, Fogli M, Bassan R, Lerede T, Rambaldi A, Barbui T, Gaidano G, Pastore C, Gloghini A, Volpe G, ... ... Rottapel R, et al. Editors’/Publisher’s Disclaimer Acta Haematologica. 95: 274-274. DOI: 10.1159/000203896 |
0.539 |
|
| 1996 |
Abraham NG, Champlin R, Giralt S, Gajewski J, Lemoli RM, Fortuna A, Fogli M, Bassan R, Lerede T, Rambaldi A, Barbui T, Gaidano G, Pastore C, Gloghini A, Volpe G, ... ... Rottapel R, et al. Contents, Vol. 95, 1996 Acta Haematologica. 95. DOI: 10.1159/000203866 |
0.473 |
|
| 1995 |
DeLapeyriere O, Naquet P, Planche J, Marchetto S, Rottapel R, Gambarelli D, Rosnet O, Birnbaum D. Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues Differentiation. 58: 351-359. PMID 7622010 DOI: 10.1046/J.1432-0436.1995.5850351.X |
0.31 |
|
| 1994 |
Pagès F, Ragueneau M, Rottapel R, Truneh A, Nunes J, Imbert J, Olive D. Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling Nature. 369: 327-329. PMID 8183372 DOI: 10.1038/369327A0 |
0.411 |
|
| 1992 |
Meininger CJ, Yano H, Rottapel R, Bernstein A, Zsebo KM, Zetter BR. The c-kit receptor ligand functions as a mast cell chemoattractant Blood. 79: 958-963. PMID 1371080 DOI: 10.1182/Blood.V79.4.958.958 |
0.549 |
|
| 1991 |
Dubreuil P, Forrester L, Rottapel R, Reedijk M, Fujita J, Bernstein A. The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice. Proceedings of the National Academy of Sciences of the United States of America. 88: 2341-5. PMID 1826051 DOI: 10.1073/Pnas.88.6.2341 |
0.672 |
|
| 1991 |
Rottapel R, Reedijk M, Williams DE, Lyman SD, Anderson DM, Pawson T, Bernstein A. The Steel/W Transduction Pathway: Kit Autophosphorylation and Its Association with a Unique Subset of Cytoplasmic Signaling Proteins Is Induced by the Steel Factor Molecular and Cellular Biology. 11: 3043-3051. PMID 1710023 DOI: 10.1128/Mcb.11.6.3043 |
0.569 |
|
| 1990 |
Dubreuil P, Rottapel R, Reith AD, Forrester L, Bernstein A. The mouse W/c-kit locus. A mammalian gene that controls the development of three distinct cell lineages. Annals of the New York Academy of Sciences. 599: 58-65. PMID 1699461 DOI: 10.1111/J.1749-6632.1990.Tb42364.X |
0.631 |
|
| 1990 |
Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes & Development. 4: 390-400. PMID 1692559 DOI: 10.1101/Gad.4.3.390 |
0.519 |
|
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