David Spaner - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Medical Biophysics, Cell Biology, Biochemistry, Oncology, Immunology

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Spaner DE, McCaw L, Wang G, Tsui H, Shi Y. Persistent janus kinase-signaling in chronic lymphocytic leukemia patients on ibrutinib: Results of a phase I trial. Cancer Medicine. PMID 30843659 DOI: 10.1002/cam4.2042  0.44
2019 Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, Yang J, Li YJ, Chen J, Filmus J, Spaner DE, Zacksenhaus E, Hao X, Ben-David Y. Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Cell Death & Disease. 10: 117. PMID 30741932 DOI: 10.1038/s41419-019-1363-1  0.32
2019 Shi Y, Wang G, Muhowski EM, McCaw L, Wang C, Bjarnason G, Woyach JA, Spaner DE. Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells. Leukemia. PMID 30696950 DOI: 10.1038/s41375-019-0381-4  0.44
2018 Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, Gajendran B, Xu D, Li YJ, Wang C, Liu W, Wen M, Spaner D, Filmus J, Zacksenhaus E, et al. Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia. The Febs Journal. PMID 30387554 DOI: 10.1111/febs.14690  0.32
2018 Spaner DE, Venema R, Huang J, Norris P, Lazarus A, Wang G, Shi Y. Association of blood IgG with tumor necrosis factor-alpha and clinical course of chronic lymphocytic leukemia. Ebiomedicine. PMID 30174282 DOI: 10.1016/j.ebiom.2018.08.045  0.44
2018 Zhu F, McCaw L, Spaner DE, Gorczynski RM. Targeting the IL-17/IL-6 axis can alter growth of Chronic Lymphocytic Leukemia in vivo/in vitro. Leukemia Research. 66: 28-38. PMID 29353760 DOI: 10.1016/j.leukres.2018.01.006  0.32
2016 McCaw L, Shi Y, Wang G, Li YJ, Spaner DE. Low Density Lipoproteins Amplify Cytokine-signaling in Chronic Lymphocytic Leukemia Cells. Ebiomedicine. PMID 27932296 DOI: 10.1016/j.ebiom.2016.11.033  0.44
2016 Oppermann S, Lam AJ, Tung S, Shi Y, McCaw L, Wang G, Ylanko J, Leber B, Andrews D, Spaner DE. Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells. Oncotarget. PMID 27579615 DOI: 10.18632/oncotarget.11618  0.44
2016 Oppermann S, Ylanko J, Shi Y, Hariharan S, Oakes CC, Brauer PM, Zúñiga-Pflücker JC, Leber B, Spaner DE, Andrews DW. Identification of kinase inhibitors that overcome venetoclax resistance in activated CLL cells by high-content screening. Blood. PMID 27297795 DOI: 10.1182/blood-2015-12-687814  0.44
2016 Duran CL, Lee DW, Jung JU, Ravi S, Pogue CB, Toussaint LG, Bayless KJ, Sitcheran R. NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway. Oncogenesis. 5: e231. PMID 27270613 DOI: 10.1038/oncsis.2016.39  0.64
2016 Wong KK, Zhu F, Khatri I, Huo Q, Spaner DE, Gorczynski RM. Characterization of CD200 Ectodomain Shedding. Plos One. 11: e0152073. PMID 27111430 DOI: 10.1371/journal.pone.0152073  0.64
2016 Spaner DE, Wang G, McCaw L, Li Y, Disperati P, Cussen MA, Shi Y. Activity of the janus kinase inhibitor Ruxolitinib in chronic lymphocytic leukemia: results of a phase II trial. Haematologica. PMID 26819050 DOI: 10.3324/haematol.2015.135418  0.64
2016 Chow S, Buckstein R, Spaner DE. A link between hypercholesterolemia and chronic lymphocytic leukemia. Leukemia & Lymphoma. 57: 797-802. PMID 26325342 DOI: 10.3109/10428194.2015.1088651  0.64
2015 Zhang MA, Ahn JJ, Zhao FL, Selvanantham T, Mallevaey T, Stock N, Correa L, Clark R, Spaner D, Dunn SE. Antagonizing Peroxisome Proliferator-Activated Receptor α Activity Selectively Enhances Th1 Immunity in Male Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 26491197 DOI: 10.4049/jimmunol.1500449  0.64
2015 Messmer D, Jacintho J, Lorrain K, Stebbins K, Bravo Y, Stock N, Cabrera G, Correa L, Chen A, Chiorazzi N, Yan XJ, Spaner D, Prasit P, Lorrain D. A selective novel Peroxisome-proliferator-activated receptor alpha (PPARα) antagonist induces apoptosis and inhibits proliferation of CLL cells in vitro and in vivo. Molecular Medicine (Cambridge, Mass.). PMID 26070013 DOI: 10.2119/molmed.2015.00139  0.64
2015 Li Y, Shi Y, McCaw L, Li YJ, Zhu F, Gorczynski R, Duncan GS, Yang B, Ben-David Y, Spaner DE. Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. Blood. PMID 26041742 DOI: 10.1182/blood-2014-12-618678  0.64
2015 Du WW, Liu F, Shan SW, Ma XC, Gupta S, Jin T, Spaner D, Krylov SN, Zhang Y, Ling W, Yang BB. Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1222-33. PMID 25896250 DOI: 10.1038/mt.2015.64  0.64
2015 Kochenderfer JN, Dudley ME, Kassim SH, Somerville RP, Carpenter RO, Stetler-Stevenson M, Yang JC, Phan GQ, Hughes MS, Sherry RM, Raffeld M, Feldman S, Lu L, Li YF, Ngo LT, ... ... Spaner DE, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 540-9. PMID 25154820 DOI: 10.1200/JCO.2014.56.2025  0.64
2014 Guirguis HR, Cheung MC, Piliotis E, Spaner D, Berinstein NL, Imrie K, Zhang L, Buckstein R. Survival of patients with transformed lymphoma in the rituximab era. Annals of Hematology. 93: 1007-14. PMID 24414374 DOI: 10.1007/s00277-013-1991-y  0.64
2014 Masoodi M, Lee E, Eiden M, Bahlo A, Shi Y, Ceddia RB, Baccei C, Prasit P, Spaner DE. A role for oleoylethanolamide in chronic lymphocytic leukemia Leukemia. 28: 1381-1387. PMID 24413323 DOI: 10.1038/leu.2014.10  0.64
2013 Tung S, Shi Y, Wong K, Zhu F, Gorczynski R, Laister RC, Minden M, Blechert AK, Genzel Y, Reichl U, Spaner DE. PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia. Blood. 122: 969-80. PMID 23814018 DOI: 10.1182/blood-2013-03-489468  0.44
2013 Haeri M, Li Y, Li Y, Li Q, Spaner DE, Ben-David Y. Insertional activation of myb by F-MuLV in SCID mice induces myeloid leukemia. International Journal of Oncology. 43: 169-76. PMID 23677281 DOI: 10.3892/ijo.2013.1943  0.64
2013 Twito T, Chen Z, Khatri I, Wong K, Spaner D, Gorczynski R. Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression. Leukemia Research. 37: 816-21. PMID 23643150 DOI: 10.1016/j.leukres.2013.04.014  0.64
2013 Tomic J, McCaw L, Li Y, Hough MR, Ben-David Y, Moffat J, Spaner DE. Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins. Experimental Hematology. 41: 675-86. PMID 23597602 DOI: 10.1016/j.exphem.2013.04.004  0.64
2013 Zhang L, Bridle BW, Chen L, Pol J, Spaner D, Boudreau JE, Rosen A, Bassett JD, Lichty BD, Bramson JL, Wan Y. Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses. Blood. 121: 2432-9. PMID 23325836 DOI: 10.1182/blood-2012-06-438481  0.64
2012 Li Y, Spaner DE. Micromanaging a large tumor suppressor. Cell Cycle (Georgetown, Tex.). 11: 4497. PMID 23222067 DOI: 10.4161/cc.22935  0.64
2012 Wong KK, Brenneman F, Chesney A, Spaner DE, Gorczynski RM. Soluble CD200 is critical to engraft chronic lymphocytic leukemia cells in immunocompromised mice. Cancer Research. 72: 4931-43. PMID 22875025 DOI: 10.1158/0008-5472.CAN-12-1390  0.64
2012 Li Y, Vecchiarelli-Federico LM, Li YJ, Egan SE, Spaner D, Hough MR, Ben-David Y. The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice. Blood. 119: 4486-98. PMID 22451425 DOI: 10.1182/blood-2011-09-378687  0.64
2012 Tung S, Spaner DE. A role for Danazol in chronic lymphocytic leukemia Leukemia. 26: 1684-1686. PMID 22289992 DOI: 10.1038/leu.2011.386  0.64
2012 Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, Maric I, Stetler-Stevenson M, Phan GQ, Hughes MS, Sherry RM, Yang JC, Kammula US, Devillier L, Carpenter R, Nathan DA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 119: 2709-20. PMID 22160384 DOI: 10.1182/blood-2011-10-384388  0.64
2012 Spaner DE. Oral high-dose glucocorticoids and Ofatumumab in fludarabine-resistant Chronic Lymphocytic Leukemia Leukemia. 26: 1144-1145. PMID 22064354 DOI: 10.1038/leu.2011.329  0.64
2011 Felizardo TC, Wang JCM, McGray RAJ, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA. Differential immune responses mediated by adenovirus-and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model Gene Therapy. 18: 986-995. PMID 21490686 DOI: 10.1038/gt.2011.53  0.64
2011 Tomic J, Lichty B, Spaner DE. Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia. Blood. 117: 2668-80. PMID 21205928 DOI: 10.1182/blood-2010-05-285999  0.64
2011 Chen CI, Bergsagel PL, Paul H, Xu W, Lau A, Dave N, Kukreti V, Wei E, Leung-Hagesteijn C, Li ZH, Brandwein J, Pantoja M, Johnston J, Gibson S, Hernandez T, ... Spaner D, et al. Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 1175-81. PMID 21189385 DOI: 10.1200/JCO.2010.29.8133  0.64
2011 Spaner D, Bahlo A. B lymphocytes in cancer immunology Experimental and Applied Immunotherapy. 37-57. DOI: 10.1007/978-1-60761-980-2_2  0.64
2010 Masoodi M, Eiden M, Koulman A, Spaner D, Volmer DA. Comprehensive lipidomics analysis of bioactive lipids in complex regulatory networks. Analytical Chemistry. 82: 8176-85. PMID 20828216 DOI: 10.1021/ac1015563  0.64
2010 Shi Y, Tomic J, Wen F, Shaha S, Bahlo A, Harrison R, Dennis JW, Williams R, Gross BJ, Walker S, Zuccolo J, Deans JP, Hart GW, Spaner DE. Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia. Leukemia. 24: 1588-98. PMID 20668475 DOI: 10.1038/leu.2010.152  0.64
2010 Lakhanpal GK, Vecchiarelli-Federico LM, Li YJ, Cui JW, Bailey ML, Spaner DE, Dumont DJ, Barber DL, Ben-David Y. The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis. Blood. 116: 428-36. PMID 20445019 DOI: 10.1182/blood-2009-10-250217  0.64
2010 Wong KK, Khatri I, Shaha S, Spaner DE, Gorczynski RM. The role of CD200 in immunity to B cell lymphoma. Journal of Leukocyte Biology. 88: 361-72. PMID 20442224 DOI: 10.1189/jlb.1009686  0.64
2010 Spaner DE, Shi Y, White D, Shaha S, He L, Masellis A, Wong K, Gorczynski R. A phase I/II trial of TLR-7 agonist immunotherapy in chronic lymphocytic leukemia Leukemia. 24: 222-226. PMID 19759558 DOI: 10.1038/leu.2009.195  0.64
2009 Shaha SP, Tomic J, Shi Y, Pham T, Mero P, White D, He L, Baryza JL, Wender PA, Booth JW, Spaner DE. Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells. Clinical and Experimental Immunology. 158: 186-98. PMID 19737143 DOI: 10.1111/j.1365-2249.2009.04003.x  0.64
2009 Romieu-Mourez R, François M, Boivin MN, Bouchentouf M, Spaner DE, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. Journal of Immunology (Baltimore, Md. : 1950). 182: 7963-73. PMID 19494321 DOI: 10.4049/jimmunol.0803864  0.64
2009 Hammond CM, Shi Y, White D, Cervi D, Tomic J, Spaner DE. The B-cell calcium sensor predicts progression of chronic lymphocytic leukemia. Leukemia. 23: 426-9. PMID 19078991 DOI: 10.1038/leu.2008.351  0.64
2009 Hicks LK, Woods A, Buckstein R, Mangel J, Pennell N, Zhang L, Imrie K, Spaner D, Cheung MC, Boudreau A, Reis M, Crump M, Berinstein NL. Rituximab purging and maintenance combined with auto-SCT: long-term molecular remissions and prolonged hypogammaglobulinemia in relapsed follicular lymphoma. Bone Marrow Transplantation. 43: 701-8. PMID 19029963 DOI: 10.1038/bmt.2008.382  0.64
2008 Spaner DE, Foley R, Galipeau J, Bramson J. Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies Oncogene. 27: 208-217. PMID 18176602 DOI: 10.1038/sj.onc.1210905  0.64
2007 Hammond CM, White D, Tomic J, Shi Y, Spaner DE. Extracellular calcium sensing promotes human B-cell activation and function. Blood. 110: 3985-95. PMID 17724142 DOI: 10.1182/blood-2007-05-088468  0.64
2007 Shi Y, White D, He L, Miller RL, Spaner DE. Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents. Cancer Research. 67: 1823-31. PMID 17308125 DOI: 10.1158/0008-5472.CAN-06-2381  0.64
2007 Spaner DE, Masellis A. Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia Leukemia. 21: 53-60. PMID 17066089 DOI: 10.1038/sj.leu.2404456  0.64
2006 Chanan-Khan A, Miller KC, Musial L, Lawrence D, Padmanabhan S, Takeshita K, Porter CW, Goodrich DW, Bernstein ZP, Wallace P, Spaner D, Mohr A, Byrne C, Hernandez-Ilizaliturri F, Chrystal C, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study Journal of Clinical Oncology. 24: 5343-5349. PMID 17088571 DOI: 10.1200/JCO.2005.05.0401  0.64
2006 Tomic J, White D, Shi Y, Mena J, Hammond C, He L, Miller RL, Spaner DE. Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity. Journal of Immunology (Baltimore, Md. : 1950). 176: 3830-9. PMID 16517754  0.64
2006 Pennell N, Woods A, Reis M, Buckstein R, Spaner D, Imrie K, Hewitt K, Boudreau A, Seth A, Berinstein NL. Association of clinical status of follicular lymphoma patients after autologous stem cell transplant and quantitative assessment of lymphoma in blood and bone marrow as measured by SYBR Green I polymerase chain reaction. The Journal of Molecular Diagnostics : Jmd. 8: 40-50. PMID 16436633 DOI: 10.2353/jmoldx.2006.050050  0.64
2006 Spaner DE, Shi Y, White D, Mena J, Hammond C, Tomic J, He L, Tomai MA, Miller RL, Booth J, Radvanyi L. Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells. Leukemia. 20: 286-95. PMID 16341037 DOI: 10.1038/sj.leu.2404061  0.64
2005 Spaner DE, Miller RL, Mena J, Grossman L, Sorrenti V, Shi Y. Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod. Leukemia & Lymphoma. 46: 935-9. PMID 16019542 DOI: 10.1080/10428190500054426  0.64
2005 Spaner DE, Hammond C, Mena J, Foden C, Deabreu A. A phase I/II trial of oxidized autologous tumor vaccines during the "watch and wait" phase of chronic lymphocytic leukemia. Cancer Immunology, Immunotherapy : Cii. 54: 635-46. PMID 15918075 DOI: 10.1007/s00262-004-0626-5  0.64
2005 Hammond C, Shi Y, Mena J, Tomic J, Cervi D, He L, Millar AE, Debenedette M, Schuh AC, Baryza JL, Wender PA, Radvanyi L, Spaner DE. Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 28: 28-39. PMID 15614042  0.64
2004 Spaner DE, Hammond C, Mena J, Shi Y. Effect of IL-2R beta-binding cytokines on costimulatory properties of chronic lymphocytic leukaemia cells: implications for immunotherapy. British Journal of Haematology. 127: 531-42. PMID 15566356 DOI: 10.1111/j.1365-2141.2004.05240.x  0.64
2004 Spaner DE. Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells. Journal of Leukocyte Biology. 76: 338-51. PMID 15277580 DOI: 10.1189/jlb.0104016  0.64
2004 Kiss TL, Chang H, Daly A, Messner HA, Jamal N, Spaner D, Rubin S, Lipton JH. Bone marrow aspirates as part of routine donor assessment for allogeneic blood and marrow transplantation can reveal presence of occult hematological malignancies in otherwise asymptomatic individuals. Bone Marrow Transplantation. 33: 855-8. PMID 14990983 DOI: 10.1038/sj.bmt.1704430  0.64
2004 Mangel J, Leitch HA, Connors JM, Buckstein R, Imrie K, Spaner D, Crump M, Pennell N, Boudreau A, Berinstein NL. Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 15: 283-90. PMID 14760123 DOI: 10.1093/annonc/mdh069  0.64
2003 Mandelcorn-Monson RL, Shear NH, Yau E, Sambhara S, Barber BH, Spaner D, DeBenedette MA. Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients. The Journal of Investigative Dermatology. 121: 550-6. PMID 12925214 DOI: 10.1046/j.1523-1747.2003.12413.x  0.64
2003 Gitelson E, Hammond C, Mena J, Lorenzo M, Buckstein R, Berinstein NL, Imrie K, Spaner DE. Chronic lymphocytic leukemia-reactive T cells during disease progression and after autologous tumor cell vaccines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 1656-65. PMID 12738718  0.64
2003 Mangel J, Buckstein R, Imrie K, Spaner D, Franssen E, Pavlin P, Boudreau A, Pennell N, Combs D, Berinstein NL. Pharmacokinetic study of patients with follicular or mantle cell lymphoma treated with rituximab as 'in vivo purge' and consolidative immunotherapy following autologous stem cell transplantation. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 14: 758-65. PMID 12702531 DOI: 10.1093/annonc/mdg201  0.64
2003 Kiss TL, Spaner D, Daly AS, Hasegawa WS, Lipton JH, Messner HA, Chang H. Complete remission of tumour with interleukin 2 therapy in a patient with non-Hodgkin's lymphoma post allogeneic bone marrow transplant associated with polyclonal T-cell bone marrow lymphocytosis. British Journal of Haematology. 120: 523-5. PMID 12580972 DOI: 10.1046/j.1365-2141.2003.04082.x  0.64
2003 Murray CA, DeKoven J, Spaner DE. Foreign body granuloma: a new manifestation of immune restoration syndrome. Journal of Cutaneous Medicine and Surgery. 7: 38-42. PMID 12362265 DOI: 10.1007/s10227-002-2102-1  0.64
2002 Spaner D, Sheng-Tanner X, Schuh AC. Aberrant regulation of superantigen responses during T-cell reconstitution and graft-versus-host disease in immunodeficient mice. Blood. 100: 2216-24. PMID 12200388  0.64
2002 Mangel J, Buckstein R, Imrie K, Spaner D, Crump M, Tompkins K, Reis M, Perez-Ordonez B, Deodhare S, Romans R, Pennell N, Robinson JB, Hewitt K, Richardson P, Lima A, et al. Immunotherapy with rituximab following high-dose therapy and autologous stem-cell transplantation for mantle cell lymphoma. Seminars in Oncology. 29: 56-69. PMID 11842390  0.64
2002 Gitelson E, Spaner D, Buckstein R, Franssen E, Hewitt K, Lim MS, Pennell N, Schultze JL, Berinstein NL. T-cell analysis in identical twins reveals an impaired anti-follicular lymphoma immune response in the patient but not in the healthy twin. British Journal of Haematology. 116: 122-7. PMID 11841404 DOI: 10.1046/j.1365-2141.2002.03240.x  0.64
2002 Berinstein NL, Buckstein R, Imrie K, Spaner D, Mangel J, Tompkins K, Pennell N, Reis M, Pavlin P, Lima A, Couvadia A, Robinson J, Richardson P. Bcl-2 clearance: Optimising outcomes in follicular non-Hodgkin's lymphoma Bone Marrow Transplantation. 29. PMID 11840156 DOI: 10.1038/sj/bmt/1703297  0.64
2001 Raju K, Rabinovich BA, Radvanyi LG, Spaner D, Miller RG. A central role for IL-2 in fate determination of mature T cells - I: Role in determining the Th1/Th2 profile in primary T cell cultures International Immunology. 13: 1453-1459. PMID 11717186  0.64
2001 Gitelson E, Ghose A, Buckstein R, Imrie K, Lim MS, Reis M, Spaner D, Tartaglia J, Berinstein NL. ALVAC-mediated gene transfer is efficient in lymphoid malignancies of T-and early B-cell origin, but not in tumors arising from mature B-cells. Cancer Immunology, Immunotherapy : Cii. 50: 345-55. PMID 11676394 DOI: 10.1007/s002620100209  0.64
2001 Buckstein RJ, Rimrie K, Pennell N, Spaner D, Hewitt K, Berinstein NL. Prolonged molecular and clinical remission after treatment of a patient with follicular lymphoma with Rituximab Leukemia and Lymphoma. 41: 451-455. PMID 11378562  0.64
2000 Sheng-Tanner X, McKerlie C, Spaner D. Characterization of graft-versus-host disease in scid mice and prevention by physicochemical stressors Transplantation. 70: 1683-1693. PMID 11152097  0.64
2000 Ghose A, Iakhnina E, Spaner D, Tartaglia J, Berinstein NL. Immunogenicity of whole-cell tumor preparations infected with the ALVAC viral vector. Human Gene Therapy. 11: 1289-301. PMID 10890739 DOI: 10.1089/10430340050032393  0.64
2000 Cao L, Yao Y, Lee V, Kiani C, Spaner D, Lin Z, Zhang Y, Adams ME, Yang BB. Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion. Journal of Cellular Biochemistry. 77: 569-83. PMID 10771513 DOI: 10.1002/(SICI)1097-4644(20000615)77:4<569::AID-JCB5>3.0.CO;2-K  0.64
2000 Lakhnina E, Spaner D, Lorenzo MN, Buckstein R, Imrie K, Reis M, Berinstein NL. Tumor-reactive t-cell lines can be generated in the presence of large numbers of cll cells: Implications for vaccine development in CLL Blood. 96.  0.64
1999 Buckstein R, Imrie K, Spaner D, Potichnyj A, Robinson JB, Nanji S, Pennel N, Reis M, Pinkerton P, Dubé I, Hewitt K, Berinstein NL. Stem cell function and engraftment is not affected by "in vivo purging" with rituximab for autologous stem cell treatment for patients with low-grade non-Hodgkin's lymphoma. Seminars in Oncology. 26: 115-22. PMID 10561026  0.64
1999 Spaner D, Sheng-Tanner X, Raju K, Rabinovich B, Messner H, Miller RG. Long-term persistence of IL-2-unresponsive allogeneic T cells in sublethally irradiated SCID mice International Immunology. 11: 1601-1614. PMID 10508178 DOI: 10.1093/intimm/11.10.1601  0.64
1999 Abraham J, Spaner D, Benchimol S. Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells. Oncogene. 18: 1521-7. PMID 10102621 DOI: 10.1038/sj.onc.1202454  0.64
1999 Spaner D, Raju K, Rabinovich B, Miller RG. A role for perforin in activation-induced T cell death in vivo: Increased expansion of allogeneic perforin-deficient T cells in SCID mice Journal of Immunology. 162: 1192-1199. PMID 9916752  0.64
1998 Couban S, Dranitsaris G, Andreou P, Price S, Tinker L, Foley R, Walker IR, Jamal S, Jamal N, Spaner D, Lipton J, Meharchand J, Messner HA. Clinical and economic analysis of allogeneic peripheral blood progenitor cell transplants: a Canadian perspective. Bone Marrow Transplantation. 22: 1199-205. PMID 9894724 DOI: 10.1038/sj.bmt.1701504  0.64
1998 Spaner D, Lowsky R, Fyles G, Lipton JH, Banerjee D, Ng CM, Wade JA, Messner HA. Acute intestinal graft-versus-host disease in a syngeneic bone marrow transplant recipient. Transplantation. 66: 1251-3. PMID 9825825  0.64
1998 Spaner D. Geographical considerations regarding donor leukocyte infusions for the treatment of relapsed hematological malignancies Cancer and Metastasis Reviews. 17: 249-257. PMID 9770122 DOI: 10.1023/A:1006079108766  0.64
1998 Radvanyi LG, Raju K, Spaner D, Mills GB, Miller RG. Interleukin-2 reverses the defect in activation-induced apoptosis in T cells from autoimmune Ipr mice Cellular Immunology. 183: 1-12. PMID 9578714 DOI: 10.1006/cimm.1997.1233  0.64
1998 Spaner D, Raju K, Radvanyi L, Lin Y, Miller RG. A role for perforin in activation-induced cell death Journal of Immunology. 160: 2655-2664. PMID 9510164  0.64
1997 Al-Fiar FZ, Colwill R, Lipton JH, Fyles G, Spaner D, Messner H. Abnormal thyroid stimulating hormone (TSH) levels in adults following allogeneic bone marrow transplants Bone Marrow Transplantation. 19: 1019-1022. PMID 9169646  0.64
1996 Spaner D. Association of human lymphocyte antigens with obstructive airways disease after bone marrow transplantation Canadian Respiratory Journal. 3: 41-46.  0.64
1995 Spaner D, Cohen BL, Miller RG, Phillips RA. Antigen-presenting cells for naive transgenic gamma delta T cells. Potent activation by activated alpha beta T cells. Journal of Immunology (Baltimore, Md. : 1950). 155: 3866-76. PMID 7561093  0.64
1994 Spaner D. Use of rearranged B- and T-cell receptor transgenes to reconstitute the peripheral lymphoid compartment of SCID mice Research in Immunology. 145: 337-344. PMID 7701111 DOI: 10.1016/S0923-2494(94)80196-7  0.64
1993 Spaner D, Migita K, Ochi A, Shannon J, Miller RG, Pereira P, Tonegawa S, Phillips RA. Gamma delta T cells differentiate into a functional but nonproliferative state during a normal immune response. Proceedings of the National Academy of Sciences of the United States of America. 90: 8415-9. PMID 8378313  0.64
1991 Phillips RA, Spaner DE. The scid mouse: Mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development and graft-versus-host disease Immunological Reviews. 63-74. PMID 1804782  0.64
1989 Chan C, Spaner D, Hyland R. Bronchiolitis obliterans after bone marrow transplantation Blood. 73: 355-356. PMID 2642716  0.64
1989 Spaner D, Dolovich J, Tarlo S, Sussman G, Buttoo K. Hypersensitivity to natural latex The Journal of Allergy and Clinical Immunology. 83: 1135-1137. PMID 2525140 DOI: 10.1016/0091-6749(89)90457-0  0.64
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