Pamela Ohashi - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Immunology, Medical Biophysics

241 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, ... ... Ohashi PS, et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection. Science (New York, N.Y.). 363: 639-644. PMID 30733420 DOI: 10.1126/science.aau9072  0.32
2019 Benveniste PM, Nakatsugawa M, Nguyen L, Ohashi PS, Hirano N, Zúñiga-Pflücker JC. In vitro-generated MART-1-specific CD8 T cells display a broader T cell receptor repertoire than naïve ex vivo and tumor infiltrating lymphocytes. Immunology and Cell Biology. PMID 30633397 DOI: 10.1111/imcb.12231  0.32
2018 Saibil SD, St Paul M, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, Grimshaw N, Robert-Tissot C, Roy DG, Jones RG, Nguyen LT, Ohashi PS. Activation of peroxisome proliferator-activated receptors α and δ synergizes with inflammatory signals to enhance adoptive cell therapy. Cancer Research. PMID 30573521 DOI: 10.1158/0008-5472.CAN-17-3053  0.48
2018 Benveniste PM, Roy S, Nakatsugawa M, Chen ELY, Nguyen L, Millar DG, Ohashi PS, Hirano N, Adams EJ, Zúñiga-Pflücker JC. Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells. Science Immunology. 3. PMID 30552102 DOI: 10.1126/sciimmunol.aav4036  0.32
2017 Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, ... ... Ohashi PS, et al. Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29109121 DOI: 10.4049/jimmunol.1600396  0.32
2017 Shen Q, Cohen B, Zheng W, Rahbar R, Martin B, Murakami K, Lamorte S, Thompson P, Berman H, Zúñiga-Pflücker JC, Ohashi PS, Reedijk M. Notch Shapes the Innate Immunophenotype in Breast Cancer. Cancer Discovery. PMID 28790030 DOI: 10.1158/2159-8290.CD-17-0037  0.32
2017 Hao Z, Sheng Y, Duncan GS, Li WY, Dominguez C, Sylvester J, Su YW, Lin GH, Snow BE, Brenner D, You-Ten A, Haight J, Inoue S, Wakeham A, Elford A, ... ... Ohashi PS, et al. K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Nature Communications. 8: 14003. PMID 28084302 DOI: 10.1038/ncomms14003  0.32
2016 Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, ... ... Ohashi PS, et al. RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 39: 1271-1280. PMID 27606466 DOI: 10.1159/000447832  0.32
2016 Rahbar R, Ohashi PS. B7-H4 is a positive regulator of antitumor immunity. Oncoimmunology. 5: e1050575. PMID 26942059 DOI: 10.1080/2162402X.2015.1050575  0.48
2016 Millar DG, Ohashi PS. Central tolerance: what you see is what you don't get! Nature Immunology. 17: 115-6. PMID 26784256 DOI: 10.1038/ni.3373  0.48
2015 Ng D, Maître B, Cummings D, Lin A, Ward LA, Rahbar R, Mossman KL, Ohashi PS, Gommerman JL. A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology. Journal of Immunology (Baltimore, Md. : 1950). 195: 4650-9. PMID 26459352 DOI: 10.4049/jimmunol.1501053  0.48
2015 Lind EF, Millar DG, Dissanayake D, Savage JC, Grimshaw NK, Kerr WG, Ohashi PS. miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1. Journal of Immunology (Baltimore, Md. : 1950). 195: 4632-40. PMID 26447227 DOI: 10.4049/jimmunol.1302941  0.48
2015 Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, ... ... Ohashi PS, et al. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death and Differentiation. PMID 25882048 DOI: 10.1038/cdd.2015.38  0.48
2015 Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, Rush JS, Smith PA, Bigaud M, Junker-Walker U, Burkhart C, Dawson J, Niwa S, Katopodis A, Nuesslein-Hildesheim B, ... ... Ohashi PS, et al. Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation. Journal of Immunology (Baltimore, Md. : 1950). 194: 3723-34. PMID 25762782 DOI: 10.4049/jimmunol.1402254  0.48
2015 Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, et al. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. Journal of Virology. 89: 4748-59. PMID 25673724 DOI: 10.1128/JVI.02976-14  0.48
2015 Nguyen LT, Ohashi PS. Clinical blockade of PD1 and LAG3--potential mechanisms of action. Nature Reviews. Immunology. 15: 45-56. PMID 25534622 DOI: 10.1038/nri3790  0.48
2015 Rahbar R, Lin A, Ghazarian M, Yau HL, Paramathas S, Lang PA, Schildknecht A, Elford AR, Garcia-Batres C, Martin B, Berman HK, Leong WL, McCready DR, Reedijk M, Done SJ, ... ... Ohashi PS, et al. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity. Cancer Immunology Research. 3: 184-95. PMID 25527357 DOI: 10.1158/2326-6066.CIR-14-0113  0.48
2015 Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, ... ... Ohashi PS, et al. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death and Differentiation. 22: 164-73. PMID 25257173 DOI: 10.1038/cdd.2014.138  0.48
2014 Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. The Journal of Clinical Investigation. 124: 3455-68. PMID 25003188 DOI: 10.1172/JCI66108  0.48
2014 Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, ... ... Ohashi PS, et al. Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. Immunity. 40: 949-60. PMID 24909887 DOI: 10.1016/j.immuni.2014.05.004  0.48
2014 Dissanayake D, Murakami K, Tran MD, Elford AR, Millar DG, Ohashi PS. Peptide-pulsed dendritic cells have superior ability to induce immune-mediated tissue destruction compared to peptide with adjuvant. Plos One. 9: e92380. PMID 24647761 DOI: 10.1371/journal.pone.0092380  0.48
2014 Lind EF, Ohashi PS. Mir-155, a central modulator of T-cell responses. European Journal of Immunology. 44: 11-5. PMID 24571026 DOI: 10.1002/eji.201343962  0.48
2014 Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, ... ... Ohashi PS, et al. IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. Cell Death and Differentiation. 21: 1050-60. PMID 24531538 DOI: 10.1038/cdd.2014.19  0.48
2014 Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, et al. Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 1060-5. PMID 24398517 DOI: 10.1073/pnas.1323166111  0.48
2014 Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, Lugli A, Zlobec I, Hartmann A, Bifulco C, Nagtegaal ID, Palmqvist R, Masucci GV, Botti G, Tatangelo F, ... ... Ohashi PS, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. The Journal of Pathology. 232: 199-209. PMID 24122236 DOI: 10.1002/path.4287  0.48
2013 Robert-Tissot C, Nguyen LT, Ohashi PS, Speiser DE. Mobilizing and evaluating anticancer T cells: pitfalls and solutions. Expert Review of Vaccines. 12: 1325-40. PMID 24127850 DOI: 10.1586/14760584.2013.843456  0.48
2013 Dervovic DD, Liang HC, Cannons JL, Elford AR, Mohtashami M, Ohashi PS, Schwartzberg PL, Zúñiga-Pflücker JC. Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch. Journal of Immunology (Baltimore, Md. : 1950). 191: 1704-15. PMID 23851691 DOI: 10.4049/jimmunol.1300417  0.48
2013 Johnson DJ, Pao LI, Dhanji S, Murakami K, Ohashi PS, Neel BG. Shp1 regulates T cell homeostasis by limiting IL-4 signals. The Journal of Experimental Medicine. 210: 1419-31. PMID 23797092 DOI: 10.1084/jem.20122239  0.48
2013 Johnson DJ, Ohashi PS. Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance. Annals of the New York Academy of Sciences. 1284: 46-51. PMID 23651192 DOI: 10.1111/nyas.12114  0.48
2013 Crome SQ, Lang PA, Lang KS, Ohashi PS. Natural killer cells regulate diverse T cell responses. Trends in Immunology. 34: 342-9. PMID 23601842 DOI: 10.1016/j.it.2013.03.002  0.48
2013 Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, ... ... Ohashi PS, et al. Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proceedings of the National Academy of Sciences of the United States of America. 110: 2593-8. PMID 23359703 DOI: 10.1073/pnas.1222264110  0.48
2013 Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, ... Ohashi PS, et al. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death and Differentiation. 20: 649-58. PMID 23328631 DOI: 10.1038/cdd.2012.167  0.48
2013 Lind EF, Elford AR, Ohashi PS. Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges. Journal of Immunology (Baltimore, Md. : 1950). 190: 1210-6. PMID 23275599 DOI: 10.4049/jimmunol.1202700  0.48
2013 Mulligan AM, Raitman I, Feeley L, Pinnaduwage D, Nguyen LT, O'Malley FP, Ohashi PS, Andrulis IL. Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 336-46. PMID 23213058 DOI: 10.1158/1078-0432.CCR-11-3314  0.48
2013 Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, ... ... Ohashi PS, et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328. PMID 23202731 DOI: 10.1172/JCI64180  0.48
2013 Lin AE, Ebert G, Ow Y, Preston SP, Toe JG, Cooney JP, Scott HW, Sasaki M, Saibil SD, Dissanayake D, Kim RH, Wakeham A, You-Ten A, Shahinian A, Duncan G, ... ... Ohashi PS, et al. ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nature Immunology. 14: 27-33. PMID 23179078 DOI: 10.1038/ni.2478  0.48
2013 Lang PA, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, et al. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. The Journal of Allergy and Clinical Immunology. 131: 815-24. PMID 23141740 DOI: 10.1016/j.jaci.2012.08.050  0.48
2013 Hamilton SR, Crome SQ, Ohashi PS. Immunological Tolerance-T Cells The Autoimmune Diseases: Fifth Edition. 87-102. DOI: 10.1016/B978-0-12-384929-8.00007-1  0.48
2012 Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW. The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. The Journal of Clinical Investigation. 122: 4698-709. PMID 23114599 DOI: 10.1172/JCI63528  0.48
2012 Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, ... ... Ohashi PS, et al. Cancer classification using the Immunoscore: a worldwide task force. Journal of Translational Medicine. 10: 205. PMID 23034130 DOI: 10.1186/1479-5876-10-205  0.48
2012 Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R. The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. Journal of Immunology (Baltimore, Md. : 1950). 189: 2138-50. PMID 22815290 DOI: 10.4049/jimmunol.1103184  0.48
2012 Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, ... ... Ohashi PS, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 488: 656-9. PMID 22763442 DOI: 10.1038/nature11323  0.48
2012 Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. Plos One. 7: e34343. PMID 22529912 DOI: 10.1371/journal.pone.0034343  0.48
2012 Rintoul JL, Lemay CG, Tai LH, Stanford MM, Falls TJ, De Souza CT, Bridle BW, Daneshmand M, Ohashi PS, Wan Y, Lichty BD, Mercer AA, Auer RC, Atkins HL, Bell JC. ORFV: A novel oncolytic and immune stimulating parapoxvirus therapeutic Molecular Therapy. 20: 1148-1157. PMID 22273579 DOI: 10.1038/mt.2011.301  0.48
2012 McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, ... Ohashi PS, et al. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (New York, N.Y.). 335: 229-32. PMID 22246778 DOI: 10.1126/science.1214448  0.48
2012 Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CG. Dysregulation of immune homeostasis in autoimmune diseases. Nature Medicine. 18: 42-7. PMID 22227671 DOI: 10.1038/nm.2621  0.48
2012 Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, ... ... Ohashi PS, et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. The Journal of Experimental Medicine. 209: 173-86. PMID 22213803 DOI: 10.1084/jem.20111363  0.48
2012 Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, ... ... Ohashi PS, et al. Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. The Journal of Experimental Medicine. 209: 77-91. PMID 22184633 DOI: 10.1084/jem.20110675  0.48
2012 Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, ... ... Ohashi PS, et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proceedings of the National Academy of Sciences of the United States of America. 109: 1210-5. PMID 22167808 DOI: 10.1073/pnas.1118834109  0.48
2011 Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto PA, Atkins MB, Bartunkova J, Bergmann L, Berinstein N, Bonorino CC, Borden E, Bramson JL, Britten CM, Cao X, ... ... Ohashi PS, et al. Defining the critical hurdles in cancer immunotherapy. Journal of Translational Medicine. 9: 214. PMID 22168571 DOI: 10.1186/1479-5876-9-214  0.48
2011 Dissanayake D, Hall H, Berg-Brown N, Elford AR, Hamilton SR, Murakami K, Deluca LS, Gommerman JL, Ohashi PS. Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells. Nature Medicine. 17: 1663-7. PMID 22081022 DOI: 10.1038/nm.2556  0.48
2011 Lin AC, Dissanayake D, Dhanji S, Elford AR, Ohashi PS. Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. Plos One. 6: e23940. PMID 21931625 DOI: 10.1371/journal.pone.0023940  0.48
2011 Dissanayake D, Gronski MA, Lin A, Elford AR, Ohashi PS. Immunological perspective of self versus tumor antigens: insights from the RIP-gp model. Immunological Reviews. 241: 164-79. PMID 21488897 DOI: 10.1111/j.1600-065X.2011.01014.x  0.48
2011 Ramanathan S, Dubois S, Chen XL, Leblanc C, Ohashi PS, Ilangumaran S. Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes. Journal of Immunology (Baltimore, Md. : 1950). 186: 5131-41. PMID 21430227 DOI: 10.4049/jimmunol.1001221  0.48
2011 Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, ... ... Ohashi PS, et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 144: 601-13. PMID 21295337 DOI: 10.1016/j.cell.2011.01.011  0.48
2011 Liontos LM, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, McGlade CJ. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. Journal of Immunology (Baltimore, Md. : 1950). 186: 1923-33. PMID 21220694 DOI: 10.4049/jimmunol.0903292  0.48
2011 Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Hermeking H, Vogelstein B, Ohashi P, Mak TW. 14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1. Proceedings of the National Academy of Sciences of the United States of America. 108: 1555-60. PMID 21205887 DOI: 10.1073/pnas.1017729108  0.48
2011 Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Hermeking H, Vogelstein B, Ohashi P, Mak TW. 14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1 (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 4, (1555-1560) DOI: 10.1073/pnas.1017729108) Proceedings of the National Academy of Sciences of the United States of America. 108: 6689. DOI: 10.1073/pnas.1104407108  0.48
2010 Murakami K, Liadis N, Sarmiento J, Elford AR, Woo M, Nguyen LT, Mak TW, Ohashi PS. Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death. European Journal of Immunology. 40: 3372-7. PMID 21110320 DOI: 10.1002/eji.201040475  0.48
2010 Nguyen LT, Yen PH, Nie J, Liadis N, Ghazarian D, Al-Habeeb A, Easson A, Leong W, Lipa J, McCready D, Reedijk M, Hogg D, Joshua AM, Quirt I, Messner H, ... ... Ohashi PS, et al. Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs). Plos One. 5: e13940. PMID 21085676 DOI: 10.1371/journal.pone.0013940  0.48
2010 Lang PA, Merkler D, Funkner P, Shaabani N, Meryk A, Krings C, Barthuber C, Recher M, Brück W, Häussinger D, Ohashi PS, Lang KS. Oxidized ATP inhibits T-cell-mediated autoimmunity. European Journal of Immunology. 40: 2401-8. PMID 20683833 DOI: 10.1002/eji.200939838  0.48
2010 Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Van Rooijen N, Kalinke U, Ludewig B, Hengartner H, Harris N, ... ... Ohashi PS, et al. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology (Baltimore, Md.). 52: 25-32. PMID 20578253 DOI: 10.1002/hep.23640  0.48
2010 Pellegrini M, Mak TW, Ohashi PS. Fighting cancers from within: augmenting tumor immunity with cytokine therapy. Trends in Pharmacological Sciences. 31: 356-63. PMID 20561689 DOI: 10.1016/j.tips.2010.05.003  0.48
2010 Lin GH, Liu Y, Ambagala T, Kwon BS, Ohashi PS, Watts TH. Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice. Plos One. 5: e11003. PMID 20543982 DOI: 10.1371/journal.pone.0011003  0.48
2010 Doulatov S, Notta F, Eppert K, Nguyen LT, Ohashi PS, Dick JE. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nature Immunology. 11: 585-93. PMID 20543838 DOI: 10.1038/ni.1889  0.48
2010 Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S. Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. Journal of Immunology (Baltimore, Md. : 1950). 185: 357-66. PMID 20519645 DOI: 10.4049/jimmunol.1000066  0.48
2010 Quintela-Fandino M, Arpaia E, Brenner D, Goh T, Yeung FA, Blaser H, Alexandrova R, Lind EF, Tusche MW, Wakeham A, Ohashi PS, Mak TW. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proceedings of the National Academy of Sciences of the United States of America. 107: 2622-7. PMID 20133759 DOI: 10.1073/pnas.0914492107  0.32
2010 Deenick EK, Elford AR, Pellegrini M, Hall H, Mak TW, Ohashi PS. c-Rel but not NF-kappaB1 is important for T regulatory cell development. European Journal of Immunology. 40: 677-81. PMID 20082358 DOI: 10.1002/eji.201040298  0.48
2010 Lin A, Schildknecht A, Nguyen LT, Ohashi PS. Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth. Immunology Letters. 127: 77-84. PMID 19778555 DOI: 10.1016/j.imlet.2009.09.003  0.48
2009 Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G, Akashi K, Lind EF, Haight JP, Ohashi PS, Look AT, Mak TW. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. The Journal of Experimental Medicine. 206: 2977-86. PMID 19995955 DOI: 10.1084/jem.20092176  0.48
2009 Alam MU, Harken JA, Knorn AM, Elford AR, Wigmore K, Ohashi PS, Millar DG. Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage. Journal of Immunology (Baltimore, Md. : 1950). 183: 5728-37. PMID 19812207 DOI: 10.4049/jimmunol.0901288  0.48
2009 Schildknecht A, Probst HC, McCoy KD, Miescher I, Brenner C, Leone DP, Suter U, Ohashi PS, van den Broek M. Antigens expressed by myelinating glia cells induce peripheral cross-tolerance of endogenous CD8+ T cells. European Journal of Immunology. 39: 1505-15. PMID 19462379 DOI: 10.1002/eji.200839019  0.48
2009 Lu YC, Kim I, Lye E, Shen F, Suzuki N, Suzuki S, Gerondakis S, Akira S, Gaffen SL, Yeh WC, Ohashi PS. Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. Journal of Immunology (Baltimore, Md. : 1950). 182: 7212-21. PMID 19454718 DOI: 10.4049/jimmunol.0802971  0.48
2009 Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nature Medicine. 15: 528-36. PMID 19396174 DOI: 10.1038/nm.1953  0.48
2009 Lang PA, Cervantes-Barragan L, Verschoor A, Navarini AA, Recher M, Pellegrini M, Flatz L, Bergthaler A, Honda K, Ludewig B, Ohashi PS, Lang KS. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood. 113: 1045-52. PMID 18971424 DOI: 10.1182/blood-2007-10-117861  0.48
2008 Lang PA, Contaldo C, Georgiev P, El-Badry AM, Recher M, Kurrer M, Cervantes-Barragan L, Ludewig B, Calzascia T, Bolinger B, Merkler D, Odermatt B, Bader M, Graf R, Clavien PA, ... ... Ohashi PS, et al. Aggravation of viral hepatitis by platelet-derived serotonin. Nature Medicine. 14: 756-61. PMID 18516052 DOI: 10.1038/nm1780  0.48
2008 Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine. 42: 145-51. PMID 18304834 DOI: 10.1016/j.cyto.2008.01.006  0.48
2008 Calzascia T, Pellegrini M, Lin A, Garza KM, Elford AR, Shahinian A, Ohashi PS, Mak TW. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 105: 2999-3004. PMID 18287017 DOI: 10.1073/pnas.0712135105  0.48
2008 Lye E, Dhanji S, Calzascia T, Elford AR, Ohashi PS. IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. European Journal of Immunology. 38: 870-6. PMID 18286567 DOI: 10.1002/eji.200737429  0.48
2008 Tsui H, Chan Y, Tang L, Winer S, Cheung RK, Paltser G, Selvanantham T, Elford AR, Ellis JR, Becker DJ, Ohashi PS, Dosch HM. Targeting of pancreatic glia in type 1 diabetes. Diabetes. 57: 918-28. PMID 18198358 DOI: 10.2337/db07-0226  0.48
2008 Dufner A, Duncan GS, Wakeham A, Elford AR, Hall HT, Ohashi PS, Mak TW. CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. Molecular and Cellular Biology. 28: 1541-52. PMID 18160713 DOI: 10.1128/MCB.01359-07  0.48
2008 Hall HT, Wilhelm MT, Saibil SD, Mak TW, Flavell RA, Ohashi PS. RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses. European Journal of Immunology. 38: 64-72. PMID 18085666 DOI: 10.1002/eji.200737393  0.48
2007 Marshak-Rothstein A, Ohashi PS. Intricate connections between innate and adaptive autoimmunity. Current Opinion in Immunology. 19: 603-5. PMID 18083508 DOI: 10.1016/j.coi.2007.10.001  0.48
2007 Calzascia T, Pellegrini M, Hall H, Sabbagh L, Ono N, Elford AR, Mak TW, Ohashi PS. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. The Journal of Clinical Investigation. 117: 3833-45. PMID 17992258 DOI: 10.1172/JCI32567  0.48
2007 Saibil SD, Deenick EK, Ohashi PS. The sound of silence: modulating anergy in T lymphocytes. Current Opinion in Immunology. 19: 658-64. PMID 17949964 DOI: 10.1016/j.coi.2007.08.005  0.48
2007 Ford MS, Chen W, Wong S, Li C, Vanama R, Elford AR, Asa SL, Ohashi PS, Zhang L. Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development. European Journal of Immunology. 37: 2234-41. PMID 17578845 DOI: 10.1002/eji.200636991  0.48
2007 Saibil SD, Jones RG, Deenick EK, Liadis N, Elford AR, Vainberg MG, Baerg H, Woodgett JA, Gerondakis S, Ohashi PS. CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Cθ c-Rel, and protein kinase B Journal of Immunology. 178: 2932-2939. PMID 17312138  0.48
2007 Lemmers B, Salmena L, Bidère N, Su H, Matysiak-Zablocki E, Murakami K, Ohashi PS, Jurisicova A, Lenardo M, Hakem R, Hakem A. Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. The Journal of Biological Chemistry. 282: 7416-23. PMID 17213198 DOI: 10.1074/jbc.M606721200  0.48
2006 Ohashi PS, Yeh WC. Supressing the supressors. Nature Medicine. 12: 1000-2. PMID 16960572 DOI: 10.1038/nm0906-1000  0.48
2006 Suh WK, Wang S, Duncan GS, Miyazaki Y, Cates E, Walker T, Gajewska BU, Deenick E, Dawicki W, Okada H, Wakeham A, Itie A, Watts TH, Ohashi PS, Jordana M, et al. Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Molecular and Cellular Biology. 26: 6403-11. PMID 16914726 DOI: 10.1128/MCB.00755-06  0.48
2006 Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, Yamasaki S, Yokosuka T, Chen NJ, Elford AR, Suzuki J, Takeuchi A, Mirtsos C, Bouchard D, Ohashi PS, et al. A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science (New York, N.Y.). 311: 1927-32. PMID 16574867 DOI: 10.1126/science.1124256  0.32
2006 Gronski MA, Ohashi PS. Tolerance and Autoimmunity: T cells The Autoimmune Diseases. 103-118. DOI: 10.1016/B978-012595961-2/50011-1  0.48
2005 Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons ME, Krawczyk CM, Gerondakis S, Yeh WC, Woodgett JM, Boothby MR, Ohashi PS. NF-κB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo Journal of Immunology. 175: 3790-3799. PMID 16148125  0.48
2005 Ohashi PS, Woodgett JR. Modulating autoimmunity: pick your PI3 kinase. Nature Medicine. 11: 924-5. PMID 16145571 DOI: 10.1038/nm0905-924  0.48
2005 Woodgett JR, Ohashi PS. GSK3: an in-Toll-erant protein kinase? Nature Immunology. 6: 751-2. PMID 16034428 DOI: 10.1038/ni0805-751  0.48
2005 Hao Z, Duncan GS, Chang CC, Elia A, Fang M, Wakeham A, Okada H, Calzascia T, Jang Y, You-Ten A, Yeh WC, Ohashi P, Wang X, Mak TW. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell. 121: 579-91. PMID 15907471 DOI: 10.1016/j.cell.2005.03.016  0.48
2005 Cheung H, Chen NJ, Cao Z, Ono N, Ohashi PS, Yeh WC. Accessory protein-like is essential for IL-18-mediated signaling. Journal of Immunology (Baltimore, Md. : 1950). 174: 5351-7. PMID 15843532  0.48
2005 Liadis N, Murakami K, Eweida M, Elford AR, Sheu L, Gaisano HY, Hakem R, Ohashi PS, Woo M. Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Molecular and Cellular Biology. 25: 3620-9. PMID 15831467 DOI: 10.1128/MCB.25.9.3620-3629.2005  0.48
2005 Kwon H, Jun HS, Yang Y, Mora C, Mariathasan S, Ohashi PS, Flavell RA, Yoon JW. Development of autoreactive diabetogenic T cells in the thymus of NOD mice. Journal of Autoimmunity. 24: 11-23. PMID 15725572 DOI: 10.1016/j.jaut.2004.10.002  0.48
2005 Krawczyk CM, Jones RG, Atfteld A, Bachmaier K, Arya S, Odermatt B, Ohashi PS, Penninger JM. Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b Journal of Immunology. 174: 1472-1478. PMID 15661906  0.48
2004 Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS. TCR affinity and negative regulation limit autoimmunity. Nature Medicine. 10: 1234-9. PMID 15467726 DOI: 10.1038/nm1114  0.48
2004 Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones R, Gronski M, Ohashi P, Wada T, et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction Immunity. 21: 167-177. PMID 15308098 DOI: 10.1016/j.immuni.2004.07.013  0.48
2004 Suh WK, Tafuri A, Berg-Brown NN, Shahinian A, Plyte S, Duncan GS, Okada H, Wakeham A, Odermatt B, Ohashi PS, Mak TW. The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28 Journal of Immunology. 172: 5917-5923. PMID 15128772  0.48
2004 Schmitt TM, de Pooter RF, Gronski MA, Cho SK, Ohashi PS, Zúñiga-Pflücker JC. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nature Immunology. 5: 410-7. PMID 15034575 DOI: 10.1038/ni1055  0.48
2004 Berg-Brown NN, Gronski MA, Jones RG, Elford AR, Deenick EK, Odermatt B, Littman DR, Ohashi PS. PKCθ Signals Activation versus Tolerance In Vivo Journal of Experimental Medicine. 199: 743-752. PMID 15024044 DOI: 10.1084/jem.20031022  0.48
2003 Ohashi PS. Negative selection and autoimmunity. Current Opinion in Immunology. 15: 668-76. PMID 14630201 DOI: 10.1016/j.coi.2003.09.013  0.48
2003 Sarvetnick N, Ohashi PS. Autoimmunity. Current Opinion in Immunology. 15: 647-50. PMID 14630198 DOI: 10.1016/j.coi.2003.09.019  0.48
2003 Millar DG, Garza KM, Odermatt B, Elford AR, Ono N, Li Z, Ohashi PS. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo Nature Medicine. 9: 1469-1476. PMID 14625545 DOI: 10.1038/nm962  0.48
2003 Holmberg K, Mariathasan S, Ohteki T, Ohashi PS, Gascoigne NR. TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. Journal of Immunology (Baltimore, Md. : 1950). 171: 2427-34. PMID 12928390  0.48
2003 Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, ... ... Ohashi PS, et al. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nature Immunology. 4: 899-906. PMID 12925852 DOI: 10.1038/ni967  0.48
2003 Pitcher LA, Ohashi PS, van Oers NS. T cell antagonism is functionally uncoupled from the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits. Journal of Immunology (Baltimore, Md. : 1950). 171: 845-52. PMID 12847253  0.48
2003 Mak TW, Shahinian A, Yoshinaga SK, Wakeham A, Boucher LM, Pintilie M, Duncan G, Gajewska BU, Gronski M, Eriksson U, Odermatt B, Ho A, Bouchard D, Whorisky JS, Jordana M, ... Ohashi PS, et al. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nature Immunology. 4: 765-72. PMID 12833154 DOI: 10.1038/ni947  0.48
2003 Suzuki N, Chen NJ, Millar DG, Suzuki S, Horacek T, Hara H, Bouchard D, Nakanishi K, Penninger JM, Ohashi PS, Yeh WC. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. Journal of Immunology (Baltimore, Md. : 1950). 170: 4031-5. PMID 12682231  0.48
2003 Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, Berry DM, Tamblyn L, Shehabeldin A, Migon E, Wakeham A, Bouchard D, Yeh WC, McGlade JC, Ohashi PS, et al. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes & Development. 17: 883-95. PMID 12654726 DOI: 10.1101/gad.1063703  0.48
2003 Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P, Penninger J, Barber B, Hunt DF, Ohashi PS. Weak agonist self-peptides promote selection and tuning of virus-specific T cells. European Journal of Immunology. 33: 685-96. PMID 12616489 DOI: 10.1002/eji.200323143  0.48
2003 Winer S, Tsui H, Lau A, Song A, Li X, Cheung RK, Sampson A, Afifiyan F, Elford A, Jackowski G, Becker DJ, Santamaria P, Ohashi P, Dosch HM. Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive. Nature Medicine. 9: 198-205. PMID 12539039 DOI: 10.1038/nm818  0.48
2002 Ohashi PS. Immunology. Exposing thy self. Science (New York, N.Y.). 298: 1348-9. PMID 12434042 DOI: 10.1126/science.1079323  0.48
2002 Bertram EM, Tafuri A, Shahinian A, Chan VS, Hunziker L, Recher M, Ohashi PS, Mak TW, Watts TH. Role of ICOS versus CD28 in antiviral immunity. European Journal of Immunology. 32: 3376-85. PMID 12432568 DOI: 10.1002/1521-4141(200212)32:12<3376::AID-IMMU3376>3.0.CO;2-Y  0.48
2002 Ohashi PS, DeFranco AL. Making and breaking tolerance. Current Opinion in Immunology. 14: 744-59. PMID 12413525 DOI: 10.1016/S0952-7915(02)00406-5  0.48
2002 Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. The Journal of Experimental Medicine. 196: 335-48. PMID 12163562 DOI: 10.1084/jem.20020307  0.48
2002 Ford MS, Young KJ, Zhang Z, Ohashi PS, Zhang L. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. The Journal of Experimental Medicine. 196: 261-7. PMID 12119351 DOI: 10.1084/jem.20020029  0.48
2002 Ohashi PS. T-cell signalling and autoimmunity: molecular mechanisms of disease. Nature Reviews. Immunology. 2: 427-38. PMID 12093009 DOI: 10.1038/nri822  0.48
2002 Kawamura KS, Su RC, Nguyen LT, Elford AR, Ohashi PS, Gariépy J. In vivo generation of cytotoxic T cells from epitopes displayed on peptide-based delivery vehicles Journal of Immunology. 168: 5709-5715. PMID 12023370  0.48
2002 Nguyen LT, Bachmann MF, Ohashi PS. Contribution of LCMV transgenic models to understanding T lymphocyte development, activation, tolerance, and autoimmunity Current Topics in Microbiology and Immunology. 263: 119-143. PMID 11987812  0.48
2002 Chan VS, Wong C, Ohashi PS. Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not in immature T cells. European Journal of Immunology. 32: 1223-9. PMID 11981809 DOI: 10.1002/1521-4141(200205)32:5<1223::AID-IMMU1223>3.0.CO;2-5  0.48
2002 Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416: 750-6. PMID 11923871 DOI: 10.1038/nature736  0.48
2002 Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16: 331-43. PMID 11911819 DOI: 10.1016/S1074-7613(02)00291-1  0.48
2002 Garza KM, McKall-Faienza KJ, Otheki T, Zakarian A, Odermatt B, Ohashi PS. Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity European Journal of Immunology. 32: 885-894. PMID 11870633 DOI: 10.1002/1521-4141(200203)32:3<885::AID-IMMU885>3.0.CO;2-E  0.48
2002 Nguyen LT, Elford AR, Murakami K, Garza KM, Schoenberger SP, Odermatt B, Speiser DE, Ohashi PS. Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance Journal of Experimental Medicine. 195: 423-435. PMID 11854356 DOI: 10.1084/jem.20010032  0.48
2001 Mak TW, Penninger JM, Ohashi PS. Knockout mice: A paradigm shift in modern immunology Nature Reviews Immunology. 1: 11-19. PMID 11905810  0.48
2001 Mariathasan S, Zakarian A, Bouchard D, Michie AM, Zúñiga-Pflücker JC, Ohashi PS. Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection. Journal of Immunology (Baltimore, Md. : 1950). 167: 4966-73. PMID 11673503  0.48
2001 Garza KM, Nguyen LT, Jones RG, Ohashi PS. Factors contributing to autoimmune disease Advances in Experimental Medicine and Biology. 490: 7-19. PMID 11505977  0.48
2001 Parsons MJ, Jones RG, Tsao MS, Odermatt B, Ohashi PS, Woodgett JR. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation. Journal of Immunology (Baltimore, Md. : 1950). 167: 42-8. PMID 11418630  0.48
2001 Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi PS, Rottapel R. A point mutation in CD28 distinguishes proliferative signals from survival signals Nature Immunology. 2: 325-332. PMID 11276203 DOI: 10.1038/86327  0.48
2001 Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 104: 33-42. PMID 11163238 DOI: 10.1016/S0092-8674(01)00189-1  0.48
2000 Garza KM, Chan VS, Ohashi PS. T cell tolerance and autoimmunity. Reviews in Immunogenetics. 2: 2-17. PMID 11324690  0.48
2000 Watanabe N, Arase H, Onodera M, Ohashi PS, Saito T. The quantity of TCR signal determines positive selection and lineage commitment of T cells Journal of Immunology. 165: 6252-6261. PMID 11086060  0.48
2000 Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13: 463-73. PMID 11070165  0.48
2000 Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, Penninger JM. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proceedings of the National Academy of Sciences of the United States of America. 97: 12272-7. PMID 11027316 DOI: 10.1073/pnas.220414397  0.48
2000 Ohteki T, Parsons M, Zakarian A, Jones RG, Nguyen LT, Woodgett JR, Ohashi PS. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. The Journal of Experimental Medicine. 192: 99-104. PMID 10880530 DOI: 10.1084/jem.192.1.99  0.48
2000 Garza KM, Chan SM, Suri R, Nguyen LT, Odermatt B, Schoenberger SP, Ohashi PS. Role of antigen-presenting cells in mediating tolerance and autoimmunity Journal of Experimental Medicine. 191: 2021-2027. PMID 10839816 DOI: 10.1084/jem.191.11.2021  0.48
2000 Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR, Ohashi PS. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. The Journal of Experimental Medicine. 191: 1721-34. PMID 10811865 DOI: 10.1084/jem.191.10.1721  0.48
2000 Mariathasan S, Ho SS, Zakarian A, Ohashi PS. Degree of ERK activation influences both positive and negative thymocyte selection. European Journal of Immunology. 30: 1060-8. PMID 10760794 DOI: 10.1002/(SICI)1521-4141(200004)30:4<1060::AID-IMMU1060>3.0.CO;2-2  0.48
2000 Nguyen LT, McKall-Faienza K, Zakarian A, Speiser DE, Mak TW, Ohashi PS. TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions. European Journal of Immunology. 30: 683-8. PMID 10671227 DOI: 10.1002/1521-4141(200002)30:2<683::AID-IMMU683>3.0.CO;2-5  0.48
2000 Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403: 211-6. PMID 10646608 DOI: 10.1038/35003228  0.48
2000 Nishimura H, Yajima T, Naiki Y, Tsunobuchi H, Umemura M, Itano K, Matsuguchi T, Suzuki M, Ohashi PS, Yoshikai Y. Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo. The Journal of Experimental Medicine. 191: 157-70. PMID 10620614 DOI: 10.1084/jem.191.1.157  0.48
1999 Bachmann MF, Ohashi PS. The role of T-cell receptor dimerization in T-cell activation Immunology Today. 20: 568-575. PMID 10562708 DOI: 10.1016/S0167-5699(99)01543-1  0.48
1999 DeBenedette MA, Wen T, Bachmann MF, Ohashi PS, Barber BH, Stocking KL, Peschon JJ, Watts TH. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus Journal of Immunology. 163: 4833-4841. PMID 10528184  0.48
1999 Nguyen LT, Duncan GS, Mirtsos C, Ng M, Speiser DE, Shahinian A, Marino MW, Mak TW, Ohashi PS, Yeh WC. TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. Immunity. 11: 379-89. PMID 10514016 DOI: 10.1016/S1074-7613(00)80113-2  0.48
1999 Ohteki T, Hessel A, Bachmann MF, Zakarian A, Sebzda E, Tsao MS, McKall-Faienza K, Odermatt B, Ohashi PS. Identification of a cross-reactive self ligand in virus-mediated autoimmunity. European Journal of Immunology. 29: 2886-96. PMID 10508263 DOI: 10.1002/(SICI)1521-4141(199909)29:09<2886::AID-IMMU2886>3.0.CO;2-A  0.48
1999 Marmor MD, Bachmann MF, Ohashi PS, Malek TR, Julius M. Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function International Immunology. 11: 1381-1393. PMID 10464159 DOI: 10.1093/intimm/11.9.1381  0.48
1999 Mariathasan S, Jones RG, Ohashi PS. Signals involved in thymocyte positive and negative selection Seminars in Immunology. 11: 263-272. PMID 10441212 DOI: 10.1006/smim.1999.0182  0.48
1999 Bachmann MF, Speiser DE, Mak TW, Ohashi PS. Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo European Journal of Immunology. 29: 2156-2166. PMID 10427978 DOI: 10.1002/(SICI)1521-4141(199907)29:07<2156::AID-IMMU2156>3.0.CO;2-P  0.48
1999 Bachmann MF, Nitschke L, Krawczyk C, Tedford K, Ohashi PS, Fischer KD, Penninger JM. The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. Journal of Immunology (Baltimore, Md. : 1950). 163: 137-42. PMID 10384109  0.48
1999 Penninger JM, Fischer KD, Sasaki T, Kozieradzki I, Le J, Tedford K, Bachmaier K, Ohashi PS, Bachmann MF. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. European Journal of Immunology. 29: 1709-18. PMID 10359126 DOI: 10.1002/(SICI)1521-4141(199905)29:05<1709::AID-IMMU1709>3.0.CO;2-O  0.48
1999 Sebzda E, Mariathasan S, Ohteki T, Jones R, Bachmann MF, Ohashi PS. Selection of the T cell repertoire Annual Review of Immunology. 17: 829-874. PMID 10358775 DOI: 10.1146/annurev.immunol.17.1.829  0.48
1999 Kägi D, Ho A, Odermatt B, Zakarian A, Ohashi PS, Mak TW. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. Journal of Immunology (Baltimore, Md. : 1950). 162: 4598-605. PMID 10201999  0.48
1999 Ohteki T, Maki C, Koyasu S, Mak TW, Ohashi PS. Cutting edge: LFA-1 is required for liver NK1.1+TCRαβ+ cell development evidence that liver NK1.1+TCRαβ+ cells originate from multiple pathways Journal of Immunology. 162: 3753-3756. PMID 10201888  0.48
1998 Kong YY, Fischer KD, Bachmann MF, Mariathasan S, Kozieradzki I, Nghiem MP, Bouchard D, Bernstein A, Ohashi PS, Penninger JM. Vav regulates peptide-specific apoptosis in thymocytes. The Journal of Experimental Medicine. 188: 2099-111. PMID 9841924 DOI: 10.1084/jem.188.11.2099  0.48
1998 Mariathasan S, Bachmann MF, Bouchard D, Ohteki T, Ohashi PS. Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. Journal of Immunology (Baltimore, Md. : 1950). 161: 6030-7. PMID 9834085  0.48
1998 Bachmann MF, Speiser DE, Zakarian A, Ohashi PS. Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism. European Journal of Immunology. 28: 3110-9. PMID 9808179 DOI: 10.1002/(SICI)1521-4141(199810)28:10<3110::AID-IMMU3110>3.0.CO;2-5  0.48
1998 Griffiths E, Ong H, Soloski MJ, Bachmann MF, Ohashi PS, Speiser DE. Tumor defense by murine cytotoxic T cells specific for peptide bound to nonclassical MHC class I Cancer Research. 58: 4682-4687. PMID 9788622  0.48
1998 Liu Q, Oliveira-Dos-Santos AJ, Mariathasan S, Bouchard D, Jones J, Sarao R, Kozieradzki I, Ohashi PS, Penninger JM, Dumont DJ. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. The Journal of Experimental Medicine. 188: 1333-42. PMID 9763612 DOI: 10.1084/jem.188.7.1333  0.48
1998 Speiser DE, Bachmann MF, Soloski MJ, Forman J, Ohashi PS. Alloreactive cytotoxic T cells recognize minor transplantation antigens presented by major histocompatibility complex class Ib molecules Transplantation. 66: 646-650. PMID 9753347 DOI: 10.1097/00007890-199809150-00017  0.48
1998 Bachmann MF, Salzmann M, Oxenius A, Ohashi PS. Formation of TCR dimers/trimers as a crucial step for T cell activation European Journal of Immunology. 28: 2571-2579. PMID 9710234 DOI: 10.1002/(SICI)1521-4141(199808)28:08<2571::AID-IMMU2571>3.0.CO;2-T  0.48
1998 McKall-Faienza KJ, Kawai K, Kündig TM, Odermatt B, Bachmann MF, Zakarian A, Mak TW, Ohashi PS. Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration. International Immunology. 10: 405-12. PMID 9620596 DOI: 10.1093/intimm/10.4.405  0.48
1998 Kawai K, Suzuki H, Tomiyama K, Minagawa M, Mak TW, Ohashi PS. Requirement of the IL-2 receptor beta chain for the development of Vgamma3 dendritic epidermal T cells. The Journal of Investigative Dermatology. 110: 961-5. PMID 9620306 DOI: 10.1046/j.1523-1747.1998.00214.x  0.48
1998 Speiser DE, Ohashi PS. Activation of cytotoxic T cells by solid tumours? Cellular and Molecular Life Sciences. 54: 263-271. PMID 9575338 DOI: 10.1007/s000180050148  0.48
1998 Bachmann MF, Waterhouse P, Speiser DE, McKall-Faienza K, Mak TW, Ohashi PS. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells Journal of Immunology. 160: 95-100. PMID 9551960  0.48
1998 Ohteki T, Yoshida H, Matsuyama T, Duncan GS, Mak TW, Ohashi PS. The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. The Journal of Experimental Medicine. 187: 967-72. PMID 9500799 DOI: 10.1084/jem.187.6.967  0.48
1997 Ohteki T, Ho S, Suzuki H, Mak TW, Ohashi PS. Role for IL-15/IL-15 Receptor β-Chain in Natural Killer 1.1+ T Cell Receptor-αβ+ Cell Development Journal of Immunology. 159: 5931-5935. PMID 9550390  0.48
1997 Ohashi PS, Sarvetnick N. Autoimmunity. A bias from tolerance to immunity Current Opinion in Immunology. 9: 815-817. PMID 9492983 DOI: 10.1016/S0952-7915(97)80183-5  0.48
1997 Bachmann MF, Mariathasan S, Bouchard D, Speiser DE, Ohashi PS. Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists. European Journal of Immunology. 27: 3414-9. PMID 9464830 DOI: 10.1002/eji.1830271241  0.48
1997 Yeh WC, Shahinian A, Speiser D, Kraunus J, Billia F, Wakeham A, De La Pompa JL, Ferrick D, Hum B, Iscove N, Ohashi P, Rothe M, Goeddel DV, Mak TW. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice Immunity. 7: 715-725. PMID 9390694 DOI: 10.1016/S1074-7613(00)80391-X  0.48
1997 Bachmann MF, Ohteki T, Faienza KM, Zakarian A, Kägi D, Speiser DE, Ohashi PS. Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis. Journal of Immunology (Baltimore, Md. : 1950). 159: 4165-70. PMID 9379009  0.48
1997 Bachmann MF, McKall-Faienza K, Schmits R, Bouchard D, Beach J, Speiser DE, Mak TW, Ohashi PS. Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation Immunity. 7: 549-557. PMID 9354475  0.48
1997 Bachmann MF, Oxenius A, Speiser DE, Mariathasan S, Hengartner H, Zinkernagel RM, Ohashi PS. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation. European Journal of Immunology. 27: 2195-203. PMID 9341759 DOI: 10.1002/eji.1830270912  0.48
1997 Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice European Journal of Immunology. 27: 1887-1892. PMID 9295023 DOI: 10.1002/eji.1830270811  0.48
1997 Speiser DE, Miranda R, Zakarian A, Bachmann MF, McKall-Faienza K, Odermatt B, Hanahan D, Zinkernagel RM, Ohashi PS. Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. The Journal of Experimental Medicine. 186: 645-53. PMID 9271580 DOI: 10.1084/jem.186.5.645  0.48
1997 Bachmann MF, Speiser DE, Ohashi PS. Functional maturation of an antiviral cytotoxic T-cell response Journal of Virology. 71: 5764-5768. PMID 9223463  0.48
1997 Iwasaki A, Torres CA, Ohashi PS, Robinson HL, Barber BH. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. Journal of Immunology (Baltimore, Md. : 1950). 159: 11-4. PMID 9200432  0.48
1997 Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS. Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner Immunity. 6: 643-653. PMID 9175842 DOI: 10.1016/S1074-7613(00)80352-0  0.48
1997 Speiser DE, Bachmann MF, Frick TW, McKall-Faienza K, Griffiths E, Pfeffer K, Mak TW, Ohashi PS. TNF receptor p55 controls early acute graft-versus-host disease1 Journal of Immunology. 158: 5185-5190. PMID 9164935  0.48
1997 Speiser DE, Lee SY, Wong B, Arron J, Santana A, Kong YY, Ohashi PS, Choi Y. A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. The Journal of Experimental Medicine. 185: 1777-83. PMID 9151703 DOI: 10.1084/jem.185.10.1777  0.48
1997 Wallace VA, Penninger JM, Kishihara K, Timms E, Shahinian A, Pircher H, Kündig TM, Ohashi PS, Mak TW. Alterations in the level of CD45 surface expression affect the outcome of thymic selection. Journal of Immunology (Baltimore, Md. : 1950). 158: 3205-14. PMID 9120275  0.48
1997 Kozieradzki I, Kündig T, Kishihara K, Ong CJ, Chiu D, Wallace VA, Kawai K, Timms E, Ionescu J, Ohashi P, Marth JD, Mak TW, Penninger JM. T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45. Journal of Immunology (Baltimore, Md. : 1950). 158: 3130-9. PMID 9120266  0.48
1997 Speiser DE, Bachmann MF, Shahinian A, Mak TW, Ohashi PS. Acute graft-versus-host disease without costimulation via CD28 Transplantation. 63: 1042-1044. PMID 9112366 DOI: 10.1097/00007890-199704150-00028  0.48
1997 Bachmann MF, Kündig TM, Speiser DE, McKall-Faienza K, Kishara K, Mak TW, Ohashi PS. T-cell-independent antiviral B cell responses in CD45-deficient mice Cellular Immunology. 175: 12-15. PMID 9015183 DOI: 10.1006/cimm.1996.1041  0.48
1997 Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function Science. 275: 540-543. PMID 8999800 DOI: 10.1126/science.275.5299.540  0.48
1996 Ohashi PS. T cell selection and autoimmunity: Flexibility and tuning Current Opinion in Immunology. 8: 808-814. PMID 8994860 DOI: 10.1016/S0952-7915(96)80009-4  0.48
1996 Speiser DE, Sebzda E, Ohteki T, Bachmann MF, Pfeffer K, Mak TW, Ohashi PS. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo European Journal of Immunology. 26: 3055-3060. PMID 8977304  0.48
1996 Bachmann MF, Sebzda E, Kündig TM, Shahinian A, Speiser DE, Mak TW, Ohashi PS. T cell responses are governed by avidity and co-stimulatory thresholds European Journal of Immunology. 26: 2017-2022. PMID 8814240  0.48
1996 Kündig TM, Bachmann MF, Oehen S, Hoffmann UW, Simard JJ, Kalberer CP, Pircher H, Ohashi PS, Hengartner H, Zinkernagel RM. On the role of antigen in maintaining cytotoxic T-cell memory. Proceedings of the National Academy of Sciences of the United States of America. 93: 9716-23. PMID 8790397 DOI: 10.1073/pnas.93.18.9716  0.48
1996 Kündig TM, Bachmann MF, Ohashi PS, Pircher H, Hengartner H, Zinkernagel RM. On T cell memory: arguments for antigen dependence. Immunological Reviews. 150: 63-90. PMID 8782702  0.48
1996 Kündig TM, Shahinian A, Kawai K, Mittrücker HW, Sebzda E, Bachmann MF, Mak TW, Ohashi PS. Duration of TCR stimulation determines costimulatory requirement of T cells Immunity. 5: 41-52. PMID 8758893 DOI: 10.1016/S1074-7613(00)80308-8  0.48
1996 Yeung RSM, Penninger JM, Kündig T, Khoo W, Ohashi PS, Kroemer G, Mak TW. Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: Supersensitivity to superantigen-induced septic shock European Journal of Immunology. 26: 1074-1082. PMID 8647170  0.48
1996 Kägi D, Odermatt B, Ohashi PS, Zinkernagel RM, Hengartner H. Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity. The Journal of Experimental Medicine. 183: 2143-52. PMID 8642324 DOI: 10.1084/jem.183.5.2143  0.48
1996 Sebzda E, Kündig TM, Thomson CT, Aoki K, Mak SY, Mayer JP, Zamborelli T, Nathenson SG, Ohashi PS. Mature T cell reactivity altered by peptide agonist that induces positive selection Journal of Experimental Medicine. 183: 1093-1104. PMID 8642251 DOI: 10.1084/jem.183.3.1093  0.48
1996 Kawai K, Shahinian A, Mak TW, Ohashi PS. Skin allograft rejection in CD28-deficient mice Transplantation. 61: 352-355. PMID 8610339 DOI: 10.1097/00007890-199602150-00003  0.48
1996 Speiser DE, Sebzda E, Ohteki T, Bachmann MF, Mak TW, Ohashi PS. TNF receptor p55 mediates peripheral cytotoxic T cell deletion Faseb Journal. 10.  0.48
1996 Bachmann MF, Sehzda E, Kuendig TM, Shahinian A, Speiser D, Mak TW, Ohashi PS. T cell responses are governed by avidity and costimulatory thresholds Faseb Journal. 10.  0.48
1995 Kawai K, Ohashi PS. Immunological function of a defined T-cell population tolerized to low-affinity self antigens Nature. 374: 68-69. PMID 7870174  0.48
1995 Kawai K, Kishihara K, Molina TJ, Wallace VA, Mak TW, Ohashi PS. Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. The Journal of Experimental Medicine. 181: 345-9. PMID 7807014  0.48
1995 Wallace VA, Kawai K, Levelt CN, Kishihara K, Molina T, Timms E, Pircher H, Penninger J, Ohashi PS, Eichmann K. T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. European Journal of Immunology. 25: 1312-8. PMID 7774634 DOI: 10.1002/eji.1830250527  0.48
1995 Ally BA, Hawley TS, McKall-Faienza KJ, Kündig TM, Oehen SU, Pircher H, Hawley RG, Ohashi PS. Prevention of autoimmune disease by retroviral-mediated gene therapy. Journal of Immunology (Baltimore, Md. : 1950). 155: 5404-8. PMID 7594557  0.48
1994 Aichele P, Kyburz D, Ohashi PS, Odermatt B, Zinkernagel RM, Hengartner H, Pircher H. Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proceedings of the National Academy of Sciences of the United States of America. 91: 444-8. PMID 8290546  0.48
1994 Sebzda E, Wallace VA, Mayer J, Yeung RS, Mak TW, Ohashi PS. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (New York, N.Y.). 263: 1615-8. PMID 8128249  0.48
1994 Fung-Leung WP, Kündig TM, Ngo K, Panakos J, De Sousa-Hitzler J, Wang E, Ohashi PS, Mak TW, Lau CY. Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice. The Journal of Experimental Medicine. 180: 959-67. PMID 8064243 DOI: 10.1084/jem.180.3.959  0.48
1994 Oehen SU, Ohashi PS, Bürki K, Hengartner H, Zinkernagel RM, Aichele P. Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels. Cellular Immunology. 158: 342-52. PMID 7923387 DOI: 10.1006/cimm.1994.1281  0.48
1994 Rahemtulla A, Kündig TM, Narendran A, Bachmann MF, Julius M, Paige CJ, Ohashi PS, Zinkernagel RM, Mak TW. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. European Journal of Immunology. 24: 2213-8. PMID 7916297 DOI: 10.1002/eji.1830240942  0.48
1994 Pircher H, Ohashi PS, Boyd RL, Hengartner H, Brduscha K. Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules. European Journal of Immunology. 24: 1982-7. PMID 7916293 DOI: 10.1002/eji.1830240907  0.48
1994 Ohashi PS. ″Ignorance is bliss″ [T cell tolerance] Immunologist. 2: 87-92.  0.48
1993 Ohashi PS, Oehen S, Aichele P, Pircher H, Odermatt B, Herrera P, Higuchi Y, Buerki K, Hengartner H, Zinkernagel RM. Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha. Journal of Immunology (Baltimore, Md. : 1950). 150: 5185-94. PMID 8496610  0.48
1993 Ohashi PS, Zinkernagel RM, Leuscher I, Hengartner H, Pircher H. Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection. International Immunology. 5: 131-8. PMID 8452813 DOI: 10.1093/intimm/5.2.131  0.48
1993 Pfeffer K, Matsuyama T, Kündig TM, Wakeham A, Kishihara K, Shahinian A, Wiegmann K, Ohashi PS, Krönke M, Mak TW. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection Cell. 73: 457-467. PMID 8387893 DOI: 10.1016/0092-8674(93)90134-C  0.48
1993 Fung-Leung WP, Louie MC, Limmer A, Ohashi PS, Ngo K, Chen L, Kawai K, Lacy E, Loh DY, Mak TW. The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes. European Journal of Immunology. 23: 2834-40. PMID 8223860 DOI: 10.1002/eji.1830231117  0.48
1993 Shahinian A, Pfeffer K, Lee KP, Kündig TM, Kishihara K, Wakeham A, Kawai K, Ohashi PS, Thompson CB, Mak TW. Differential T cell costimulatory requirements in CD28-deficient mice Science. 261: 609-612. PMID 7688139  0.48
1992 Crompton T, Macdonald HR, Ohashi P, Schneider SD, Pircher H. A cortisone sensitive cd3|0w subset of d4+cd8" thymocytes represents an intermediate stage in intrathymic repertoire selection International Immunology. 4: 153-161. PMID 1535784 DOI: 10.1093/intimm/4.2.153  0.48
1992 Speiser DE, Pircher H, Ohashi PS, Kyburz D, Hengartner H, Zinkernagel RM. Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny. The Journal of Experimental Medicine. 175: 1277-83. PMID 1533241  0.48
1992 Zinkernagel RM, Pircher H, Ohashi PS, Hengartner H. T cells causing immunological disease. Springer Seminars in Immunopathology. 14: 105-13. PMID 1475738 DOI: 10.1007/BF00195288  0.48
1992 Higuchi Y, Herrera P, Muniesa P, Huarte J, Belin D, Ohashi P, Aichele P, Orci L, Vassalli JD, Vassalli P. Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. The Journal of Experimental Medicine. 176: 1719-31. PMID 1460428 DOI: 10.1084/jem.176.6.1719  0.48
1992 Oehen S, Ohashi PS, Aichele P, Bürki K, Hengartner H, Zinkernagel RM. Vaccination or tolerance to prevent diabetes. European Journal of Immunology. 22: 3149-53. PMID 1446706 DOI: 10.1002/eji.1830221218  0.48
1991 Zinkernagel RM, Pircher HP, Ohashi P, Oehen S, Odermatt B, Mak T, Arnheiter H, Bürki K, Hengartner H. T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease. Immunological Reviews. 122: 133-71. PMID 1937540  0.48
1991 Ohashi PS, Oehen S, Buerki K, Pircher H, Ohashi CT, Odermatt B, Malissen B, Zinkernagel RM, Hengartner H. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 65: 305-17. PMID 1901764 DOI: 10.1016/0092-8674(91)90164-T  0.48
1990 Ohashi PS, Wallace VA, Broughton H, Ohashi CT, Ferrick DA, Jost V, Mak TW, Hengartner H, Pircher H. Specific deletion of the J-C delta locus in murine alpha/beta T cell clones and studies using transgenic mice. European Journal of Immunology. 20: 517-22. PMID 2318248 DOI: 10.1002/eji.1830200309  0.48
1990 Wallace VA, Ohashi PS, Hengartner H, Mak TW. Expression of CD4 can confer major histocompatibility complex class II-associated superantigen reactivity upon a T cell receptor derived from a CD8-dependent cytotoxic T lymphocyte clone. European Journal of Immunology. 20: 2471-7. PMID 2123792 DOI: 10.1002/eji.1830201117  0.48
1990 Ferrick DA, Ohashi PS, Wallace VA, Schilham M, Mak TW. Transgenic mice as an in vivo model for self-reactivity. Immunological Reviews. 118: 257-83. PMID 2079328  0.48
1990 Ohashi PS, Pircher H, Bürki K, Zinkernagel RM, Hengartner H. Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities. Nature. 346: 861-3. PMID 1975427 DOI: 10.1038/346861a0  0.48
1990 Pircher H, Ohashi P, Miescher G, Lang R, Zikopoulos A, Bürki K, Mak TW, MacDonald HR, Hengartner H. T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population. European Journal of Immunology. 20: 417-24. PMID 1968840 DOI: 10.1002/eji.1830200227  0.48
1989 Ohashi PS, Pircher H, Mak TW, Bürki K, Zinkernagel RM, Hengartner H. Ontogeny and selection of the T cell repertoire in transgenic mice. Seminars in Immunology. 1: 95-104. PMID 15630811  0.48
1989 Ferrick DA, Ohashi PS, Wallace V, Schilham M, Mak TW. Thymic ontogeny and selection of αβ and γδ T cells Immunology Today. 10: 403-407. PMID 2619879 DOI: 10.1016/0167-5699(89)90035-2  0.48
1988 Ballhausen WG, Reske-Kunz AB, Tourvieille B, Ohashi PS, Parnes JR, Mak TW. Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma Journal of Experimental Medicine. 167: 1493-1498. PMID 2965740  0.48
1987 Mak TW, Caccia N, Reis M, Ohashi P, Sangster R, Kimura N, Toyonaga B. Genes Encoding the α, β, and γ Chains of the Human T Cell Antigen Receptor Journal of Infectious Diseases. 155: 418-422. PMID 3543154 DOI: 10.1093/infdis/155.3.418  0.48
1987 Iwamoto A, Ohashi PS, Pircher H, Walker CL, Michalopoulos EE, Rupp F, Hengartner H, Mak TW. T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones. The Journal of Experimental Medicine. 165: 591-600. PMID 3493320 DOI: 10.1084/jem.165.3.591  0.48
1987 Pircher H, Michalopoulos EE, Iwamoto A, Ohashi PS, Baenziger J, Hengartner H, Zinkernagel RM, Mak TW. Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identification of a new V(α) family European Journal of Immunology. 17: 1843-1846. PMID 2961577  0.48
1986 Iwamoto A, Rupp F, Ohashi PS, Walker CL, Pircher H, Joho R, Hengartner H, Mak TW. T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. The Journal of Experimental Medicine. 163: 1203-12. PMID 3486244 DOI: 10.1084/jem.163.5.1203  0.48
1986 Mak TW, Caccia N, Kimura N, Spolski R, Iwamoto A, Ohashi P, Reis MD, Toyonaga B. Structures and evolution of the T-cell antigen receptor genes Cold Spring Harbor Symposia On Quantitative Biology. 51: 797-802. PMID 3472762  0.48
1986 Mak TW, Caccia N, Reis M, Ohashi P, Sangster R, Kimura N, Toyonaga B. Genes encoding the alpha, beta, and gamma chains of the human T-cell antigen receptor Aids Research. 2. PMID 2950867  0.48
1985 Ohashi PS, Mak TW, Van Den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, Terhorst C, Stobo JD, Weiss A. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer Nature. 316: 606-609. PMID 4033759 DOI: 10.1038/316606a0  0.48
1985 Weiss A, Ohashi P, Yanagi Y. T3/T cell antigen receptor (Ti) mutants: Characterization and reconstitution of expression by transfection of the Ti β-chain gene Federation Proceedings. 44.  0.48
1982 Brunk CF, Tsao SG, Diamond CH, Ohashi PS, Tsao NN, Pearlman RE. Reorganization of unique and repetitive sequences during nuclear development in Tetrahymena thermophila. Canadian Journal of Biochemistry. 60: 847-53. PMID 7172094  0.48
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