Anjana Rao - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Molecular Biology, Biochemistry
Website:
http://www.lji.org/faculty-staff/anjana-rao/

286 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 López-Moyado IF, Ko M, Hogan PG, Rao A. TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer. Annual Review of Immunology. PMID 38360546 DOI: 10.1146/annurev-immunol-080223-044610  0.334
2022 Georges RO, Sepulveda H, Angel JC, Johnson E, Palomino S, Nowak RB, Desai A, López-Moyado IF, Rao A. Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3. Nature Communications. 13: 6230. PMID 36266342 DOI: 10.1038/s41467-022-33742-7  0.314
2021 Nguyen NT, Huang K, Zeng H, Jing J, Wang R, Fang S, Chen J, Liu X, Huang Z, You MJ, Rao A, Huang Y, Han G, Zhou Y. Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nature Nanotechnology. PMID 34697491 DOI: 10.1038/s41565-021-00982-5  0.8
2021 Yue X, Samaniego-Castruita D, González-Avalos E, Li X, Barwick BG, Rao A. Whole-genome analysis of TET dioxygenase function in regulatory T cells. Embo Reports. e52716. PMID 34288360 DOI: 10.15252/embr.202152716  0.392
2021 Seo H, González-Avalos E, Zhang W, Ramchandani P, Yang C, Lio CJ, Rao A, Hogan PG. BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. Nature Immunology. PMID 34282330 DOI: 10.1038/s41590-021-00964-8  0.317
2020 Reilly BM, Luger T, Park S, Lio CJ, Gonzalez-Avalos E, Wheeler EC, Lee M, Williamson L, Tanaka T, Diep D, Zhang K, Huang Y, Rao A, Bejar R. 5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells. Molecular Cancer Research : McR. PMID 33172974 DOI: 10.1158/1541-7786.MCR-20-0453  0.471
2020 Yue X, Rao A. TET-family dioxygenases and the TET activator Vitamin C in immune responses and cancer. Blood. PMID 32730592 DOI: 10.1182/Blood.2019004158  0.333
2020 Conley JM, Gallagher MP, Rao A, Berg LJ. Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength. Journal of Immunology (Baltimore, Md. : 1950). PMID 32493815 DOI: 10.4049/Jimmunol.1900853  0.399
2020 Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL. Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 32253314 DOI: 10.1073/Pnas.1913788117  0.312
2020 Lio CJ, Yue X, Lopez-Moyado IF, Tahiliani M, Aravind L, Rao A. TET methylcytosine oxidases: new insights from a decade of research. Journal of Biosciences. 45. PMID 31965999 DOI: 10.1007/S12038-019-9973-4  0.781
2020 Bajaj J, Hamilton M, Shima Y, Chambers K, Spinler K, Van Nostrand EL, Yee BA, Blue SM, Chen M, Rizzeri D, Chuah C, Oehler VG, Broome HE, Sasik R, Scott-Browne J, ... Rao A, et al. An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia Nature Cancer. 1: 410-422. DOI: 10.1038/S43018-020-0054-2  0.324
2019 Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, et al. Defining 'T cell exhaustion'. Nature Reviews. Immunology. PMID 31570879 DOI: 10.1038/S41577-019-0221-9  0.421
2019 Lio CJ, Yuita H, Rao A. Dysregulation of the TET family of epigenetic regulators in hematopoietic malignancies. Blood. PMID 31467060 DOI: 10.1182/Blood.2019791475  0.397
2019 López-Moyado IF, Tsagaratou A, Yuita H, Seo H, Delatte B, Heinz S, Benner C, Rao A. Paradoxical association of TET loss of function with genome-wide DNA hypomethylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31371502 DOI: 10.1073/Pnas.1903059116  0.389
2019 Seo H, Chen J, González-Avalos E, Samaniego-Castruita D, Das A, Wang YH, López-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8 T cell exhaustion. Proceedings of the National Academy of Sciences of the United States of America. PMID 31152140 DOI: 10.1073/Pnas.1905675116  0.425
2019 Yue X, Lio CJ, Samaniego-Castruita D, Li X, Rao A. Loss of TET2 and TET3 in regulatory T cells unleashes effector function. Nature Communications. 10: 2011. PMID 31043609 DOI: 10.1038/S41467-019-09541-Y  0.427
2019 Lio CJ, Shukla V, Samaniego-Castruita D, González-Avalos E, Chakraborty A, Yue X, Schatz DG, Ay F, Rao A. TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the superenhancer. Science Immunology. 4. PMID 31028100 DOI: 10.1126/Sciimmunol.Aau7523  0.42
2019 Mognol GP, González-Avalos E, Ghosh S, Spreafico R, Gudlur A, Rao A, Damoiseaux R, Hogan PG. Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31019078 DOI: 10.1073/Pnas.1820604116  0.406
2019 Chen J, López-Moyado IF, Seo H, Lio CJ, Hempleman LJ, Sekiya T, Yoshimura A, Scott-Browne JP, Rao A. NR4A transcription factors limit CAR T cell function in solid tumours. Nature. PMID 30814732 DOI: 10.1038/S41586-019-0985-X  0.46
2019 Chen J, Scott-Browne JP, Lopez-Moyado IF, Hempleman LJ, Seo H, Sekiya T, Yoshimura A, Rao A. Abstract A178: Nr4a transcription factors limit CAR T-cell function in solid tumors Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A178  0.441
2019 Seo H, Chen J, Das A, Bhandoola A, Rao A. Abstract 938: Disruption of TOX overcomes CAR T-cell dysfunction function in solid tumor Cancer Research. 79: 938-938. DOI: 10.1158/1538-7445.Am2019-938  0.398
2019 Chen J, Lopez-Moyado IF, Seo H, Lio CJ, Hempleman LJ, Sekiya T, Yoshimura A, Scott-Browne JP, Rao A. Abstract 937: Nr4a transcription factors limit CAR T-cell function in solid tumors Cancer Research. 79: 937-937. DOI: 10.1158/1538-7445.Am2019-937  0.415
2018 Schmiedel BJ, Singh D, Madrigal A, Valdovino-Gonzalez AG, White BM, Zapardiel-Gonzalo J, Ha B, Altay G, Greenbaum JA, McVicker G, Seumois G, Rao A, Kronenberg M, Peters B, Vijayanand P. Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression. Cell. PMID 30449622 DOI: 10.1016/J.Cell.2018.10.022  0.368
2018 Shepherd MS, Li J, Wilson NK, Oedekoven CA, Li J, Belmonte M, Fink J, Prick JCM, Pask DC, Hamilton TL, Löffler D, Rao A, Schroeder T, Göttgens B, Green AR, et al. Single cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal. Blood. PMID 29991556 DOI: 10.1182/Blood-2017-12-821066  0.373
2018 Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, et al. TCR signal strength controls thymic differentiation of iNKT cell subsets. Nature Communications. 9: 2650. PMID 29985393 DOI: 10.1038/S41467-018-05026-6  0.426
2018 Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. PMID 29887596 DOI: 10.1038/S41388-018-0301-5  0.426
2017 Märklin M, Heitmann JS, Fuchs AR, Truckenmüller FM, Gutknecht M, Bugl S, Saur SJ, Lazarus J, Kohlhofer U, Quintanilla-Martinez L, Rammensee HG, Salih HR, Kopp HG, Haap M, Kirschniak A, ... ... Rao A, et al. NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia. Nature Communications. 8: 755. PMID 28970470 DOI: 10.1038/S41467-017-00830-Y  0.37
2017 Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW. Erratum: The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nature Immunology. 18: 1173. PMID 28926530 DOI: 10.1038/ni1017-1173d  0.483
2017 Scott-Browne JP, Lio CJ, Rao A. TET proteins in natural and induced differentiation. Current Opinion in Genetics & Development. 46: 202-208. PMID 28888139 DOI: 10.1016/J.Gde.2017.07.011  0.39
2017 Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Yang Y, Zhou Y, Rao A, You MJ, Sun D, Huang Y. Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis. The Journal of Clinical Investigation. PMID 28691928 DOI: 10.1172/Jci92026  0.677
2017 Pereira RM, Hogan PG, Rao A, Martinez GJ. Transcriptional and epigenetic regulation of T cell hyporesponsiveness. Journal of Leukocyte Biology. PMID 28606939 DOI: 10.1189/Jlb.2Ri0317-097R  0.424
2017 Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW. The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nature Immunology. PMID 28530712 DOI: 10.1038/Ni.3755  0.597
2017 Khoueiry R, Sohni A, Thienpont B, Luo X, Velde JV, Bartoccetti M, Boeckx B, Zwijsen A, Rao A, Lambrechts D, Koh KP. Lineage-specific functions of TET1 in the postimplantation mouse embryo. Nature Genetics. PMID 28504700 DOI: 10.1038/Ng.3868  0.398
2017 An J, Rao A, Ko M. TET family dioxygenases and DNA demethylation in stem cells and cancers. Experimental & Molecular Medicine. 49: e323. PMID 28450733 DOI: 10.1038/Emm.2017.5  0.383
2017 Tsagaratou A, Lio CJ, Yue X, Rao A. TET Methylcytosine Oxidases in T Cell and B Cell Development and Function. Frontiers in Immunology. 8: 220. PMID 28408905 DOI: 10.3389/Fimmu.2017.00220  0.446
2017 Mognol GP, Spreafico R, Wong V, Scott-Browne JP, Togher S, Hoffmann A, Hogan PG, Rao A, Trifari S. Exhaustion-associated regulatory regions in CD8(+) tumor-infiltrating T cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28283662 DOI: 10.1073/Pnas.1620498114  0.4
2017 Tsagaratou A, González-Avalos E, Rautio S, Scott-Browne JP, Togher S, Pastor WA, Rothenberg EV, Chavez L, Lähdesmäki H, Rao A. TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells. Nature Immunology. 18: 45-53. PMID 27869820 DOI: 10.1038/Ni.3630  0.747
2016 Scott-Browne JP, López-Moyado IF, Trifari S, Wong V, Chavez L, Rao A, Pereira RM. Dynamic Changes in Chromatin Accessibility Occur in CD8(+) T Cells Responding to Viral Infection. Immunity. PMID 27939672 DOI: 10.1016/J.Immuni.2016.10.028  0.419
2016 Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans SM, Rao A. Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 27930333 DOI: 10.1073/Pnas.1617802113  0.703
2016 Lio CJ, Zhang J, González-Avalos E, Hogan PG, Chang X, Rao A. Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility. Elife. 5. PMID 27869616 DOI: 10.7554/Elife.18290  0.422
2016 Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MA. DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nature Genetics. PMID 27428748 DOI: 10.1038/Ng.3610  0.532
2016 Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S. TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Reports. PMID 27160912 DOI: 10.1016/J.Celrep.2016.04.044  0.427
2016 Äijö T, Huang Y, Mannerström H, Chavez L, Tsagaratou A, Rao A, Lähdesmäki H. A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways. Genome Biology. 17: 49. PMID 26975309 DOI: 10.1186/S13059-016-0911-6  0.501
2016 Yue X, Trifari S, Äijö T, Tsagaratou A, Pastor WA, Zepeda-Martínez JA, Lio CJ, Li X, Huang Y, Vijayanand P, Lähdesmäki H, Rao A. Control of Foxp3 stability through modulation of TET activity. The Journal of Experimental Medicine. PMID 26903244 DOI: 10.1084/Jem.20151438  0.766
2016 Martinez GJ, Hu JK, Pereira RM, Crampton JS, Togher S, Bild N, Crotty S, Rao A. Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 26851216 DOI: 10.4049/Jimmunol.1501841  0.463
2016 Lio C, Zhang J, González-Avalos E, Hogan PG, Chang X, Rao A. Author response: Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility Elife. DOI: 10.7554/Elife.18290.030  0.359
2016 Heitmann JS, Märklin M, Anastasia P, Fuchs AR, Truckenmüller FM, Kopp H, Kanz L, Rao A, Wirths S, Mueller MR. Knock-Down of the NFAT2 Long and Intermediate Isoforms Leads to CLL Acceleration Blood. 128: 4371-4371. DOI: 10.1182/Blood.V128.22.4371.4371  0.401
2015 Quintana A, Rajanikanth V, Farber-Katz S, Gudlur A, Zhang C, Jing J, Zhou Y, Rao A, Hogan PG. TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644574 DOI: 10.1073/Pnas.1521924112  0.734
2015 An J, González-Avalos E, Chawla A, Jeong M, López-Moyado IF, Li W, Goodell MA, Chavez L, Ko M, Rao A. Acute loss of TET function results in aggressive myeloid cancer in mice. Nature Communications. 6: 10071. PMID 26607761 DOI: 10.1038/Ncomms10071  0.383
2015 Ko M, An J, Rao A. DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Current Opinion in Cell Biology. 37: 91-101. PMID 26595486 DOI: 10.1016/J.Ceb.2015.10.009  0.34
2015 Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, Rao A. Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: E4236-45. PMID 26199412 DOI: 10.1073/Pnas.1510510112  0.71
2015 Balasubramani A, Larjo A, Bassein JA, Chang X, Hastie RB, Togher SM, Lähdesmäki H, Rao A. Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nature Communications. 6: 7307. PMID 26095772 DOI: 10.1038/Ncomms8307  0.328
2015 Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, ... ... Rao A, et al. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nature Cell Biology. 17: 545-57. PMID 25915124 DOI: 10.1038/Ncb3147  0.521
2015 Chang X, Li B, Rao A. RNA-binding protein hnRNPLL regulates mRNA splicing and stability during B-cell to plasma-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 112: E1888-97. PMID 25825742 DOI: 10.1073/Pnas.1422490112  0.383
2015 Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, ... Rao A, et al. The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. Immunity. 42: 265-78. PMID 25680272 DOI: 10.1016/J.Immuni.2015.01.006  0.442
2015 Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon LI, ... ... Rao A, et al. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Molecular and Cellular Biology. 35: 789-804. PMID 25512612 DOI: 10.1128/Mcb.00971-14  0.357
2015 Ko M, An J, Pastor WA, Koralov SB, Rajewsky K, Rao A. TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunological Reviews. 263: 6-21. PMID 25510268 DOI: 10.1111/Imr.12239  0.706
2015 Maerklin M, Heitmann JS, Truckenmueller F, Ganser M, Kopp H, Wirths S, Kanz L, Rao A, Mueller MR. NFAT2 to regulate anergy induction in CLL through Lck. Journal of Clinical Oncology. 33: 7019-7019. DOI: 10.1200/Jco.2015.33.15_Suppl.7019  0.367
2015 Märklin M, Heitmann J, Truckenmüller F, Kanz L, Saur SJ, Ganser M, Stefanie B, Kopp H, Haap M, Rao A, Wirths S, Mueller MR. Genetic Loss of NFAT2 Leads to CLL Transformation Blood. 126: 364-364. DOI: 10.1182/Blood.V126.23.364.364  0.386
2014 Chavez L, Huang Y, Luong K, Agarwal S, Iyer LM, Pastor WA, Hench VK, Frazier-Bowers SA, Korol E, Liu S, Tahiliani M, Wang Y, Clark TA, Korlach J, Pukkila PJ, ... ... Rao A, et al. Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea. Proceedings of the National Academy of Sciences of the United States of America. 111: E5149-58. PMID 25406324 DOI: 10.1073/Pnas.1419513111  0.783
2014 Chen R, Bélanger S, Frederick MA, Li B, Johnston RJ, Xiao N, Liu YC, Sharma S, Peters B, Rao A, Crotty S, Pipkin ME. In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation. Immunity. 41: 325-38. PMID 25148027 DOI: 10.1016/J.Immuni.2014.08.002  0.418
2014 Huang Y, Rao A. Connections between TET proteins and aberrant DNA modification in cancer. Trends in Genetics : Tig. 30: 464-74. PMID 25132561 DOI: 10.1016/J.Tig.2014.07.005  0.485
2014 Pereira RM, Martinez GJ, Engel I, Cruz-Guilloty F, Barboza BA, Tsagaratou A, Lio CW, Berg LJ, Lee Y, Kronenberg M, Bandukwala HS, Rao A. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nature Communications. 5: 4540. PMID 25105474 DOI: 10.1038/Ncomms5540  0.807
2014 Tsagaratou A, Äijö T, Lio CW, Yue X, Huang Y, Jacobsen SE, Lähdesmäki H, Rao A. Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: E3306-15. PMID 25071199 DOI: 10.1073/Pnas.1412327111  0.582
2014 Seumois G, Chavez L, Gerasimova A, Lienhard M, Omran N, Kalinke L, Vedanayagam M, Ganesan AP, Chawla A, Djukanović R, Ansel KM, Peters B, Rao A, Vijayanand P. Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nature Immunology. 15: 777-88. PMID 24997565 DOI: 10.1038/Ni.2937  0.423
2014 Carlson TJ, Pellerin A, Djuretic IM, Trivigno C, Koralov SB, Rao A, Sundrud MS. Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation. Journal of Immunology (Baltimore, Md. : 1950). 192: 2167-76. PMID 24489094 DOI: 10.4049/Jimmunol.1302316  0.791
2014 Huang Y, Chavez L, Chang X, Wang X, Pastor WA, Kang J, Zepeda-Martínez JA, Pape UJ, Jacobsen SE, Peters B, Rao A. Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 1361-6. PMID 24474761 DOI: 10.1073/Pnas.1322921111  0.758
2014 Iyer LM, Zhang D, de Souza RF, Pukkila PJ, Rao A, Aravind L. Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes. Proceedings of the National Academy of Sciences of the United States of America. 111: 1676-83. PMID 24398522 DOI: 10.1073/Pnas.1321818111  0.385
2014 Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, ... ... Rao A, et al. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nature Genetics. 46: 17-23. PMID 24270360 DOI: 10.1038/Ng.2836  0.538
2014 Märklin M, Heitmann JS, Poljak A, Bugl S, Kopp H, Haap M, Kanz L, Rao A, Wirths S, Müller MR. NFAT2 Regulates Anergy Induction in CLL through Lck Blood. 124: 720-720. DOI: 10.1182/Blood.V124.21.720.720  0.411
2014 Zhang X, Jeong M, Su J, Ko MG, Huang Y, Park HJ, Rao A, Li W, Goodell MA. Dnmt3a and Tet2 interact to Repress differentiation lineage-specific transcriptional factors in Hematopoietic Stem Cells By the Regulation of Epigenome Blood. 124: 242-242. DOI: 10.1182/Blood.V124.21.242.242  0.539
2014 Gudlur A, Quintana A, Zhou Y, Rao A, Hogan PG. Mechanism of Activation of Calcium Channel Orai1 by its Regulatory Partner Stim1 Biophysical Journal. 106: 315a. DOI: 10.1016/J.Bpj.2013.11.1821  0.521
2013 Vandenberghe M, Raphaël M, Lehen'kyi V, Gordienko D, Hastie R, Oddos T, Rao A, Hogan PG, Skryma R, Prevarskaya N. ORAI1 calcium channel orchestrates skin homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 110: E4839-48. PMID 24277812 DOI: 10.1073/Pnas.1310394110  0.305
2013 Trifari S, Pipkin ME, Bandukwala HS, Äijö T, Bassein J, Chen R, Martinez GJ, Rao A. MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 18608-13. PMID 24163352 DOI: 10.1073/Pnas.1317191110  0.35
2013 Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, et al. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. Journal of Immunology (Baltimore, Md. : 1950). 191: 3100-11. PMID 23966625 DOI: 10.4049/Jimmunol.1301360  0.337
2013 Zhou Y, Srinivasan P, Razavi S, Seymour S, Meraner P, Gudlur A, Stathopulos PB, Ikura M, Rao A, Hogan PG. Initial activation of STIM1, the regulator of store-operated calcium entry. Nature Structural & Molecular Biology. 20: 973-81. PMID 23851458 DOI: 10.1038/Nsmb.2625  0.531
2013 Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, ... Rao A, et al. Global epigenomic reconfiguration during mammalian brain development. Science (New York, N.Y.). 341: 1237905. PMID 23828890 DOI: 10.1126/Science.1237905  0.463
2013 Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 500: 222-6. PMID 23812591 DOI: 10.1038/Nature12362  0.372
2013 Pastor WA, Aravind L, Rao A. TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nature Reviews. Molecular Cell Biology. 14: 341-56. PMID 23698584 DOI: 10.1038/Nrm3589  0.696
2013 Ko M, An J, Bandukwala HS, Chavez L, Aijö T, Pastor WA, Segal MF, Li H, Koh KP, Lähdesmäki H, Hogan PG, Aravind L, Rao A. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. 497: 122-6. PMID 23563267 DOI: 10.1038/Nature12052  0.708
2013 Oh-Hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, Rao A, Takayanagi H. Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. Immunity. 38: 881-95. PMID 23499491 DOI: 10.1016/J.Immuni.2013.02.008  0.666
2013 Koh KP, Rao A. DNA methylation and methylcytosine oxidation in cell fate decisions. Current Opinion in Cell Biology. 25: 152-61. PMID 23498662 DOI: 10.1016/J.Ceb.2013.02.014  0.401
2013 Bandukwala HS, Rao A. 'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression. Nature Immunology. 14: 201-3. PMID 23416671 DOI: 10.1038/Ni.2546  0.404
2013 Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell. 12: 470-8. PMID 23415914 DOI: 10.1016/J.Stem.2013.01.016  0.522
2013 Yigit E, Zhang Q, Xi L, Grilley D, Widom J, Wang JP, Rao A, Pipkin ME. High-resolution nucleosome mapping of targeted regions using BAC-based enrichment. Nucleic Acids Research. 41: e87. PMID 23413004 DOI: 10.1093/Nar/Gkt081  0.367
2013 Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. The Journal of Experimental Medicine. 210: 417-32. PMID 23382546 DOI: 10.1084/Jem.20111717  0.376
2013 Märklin M, Heitmann JS, BS, Worbs D, Poljak A, Evouna C, Kopp H, Kanz L, Rao A, Wirths S, Müller MR. NFAT2 Is a Critical Regulator Of Anergy Induction In CLL Blood. 122: 869-869. DOI: 10.1182/Blood.V122.21.869.869  0.368
2013 Märklin M, Heitmann JS, Worbs D, Poljak A, Evouna C, Kopp H, Kanz L, Rao A, Wirths S, Müller MR. Transcriptional Mistargeting Of NFAT2 In CLL Blood. 122: 4122-4122. DOI: 10.1182/Blood.V122.21.4122.4122  0.408
2013 Jeong M, Sun D, Luo M, Huang Y, Ko M, Chavez L, Challen GA, Rodriguez B, Zhang X, Yang L, Wang H, Chen R, Hannah R, Kim S, Lee J, ... ... Rao A, et al. Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a Blood. 122: 2406-2406. DOI: 10.1182/Blood.V122.21.2406.2406  0.536
2013 Zhou Y, Seymour S, Razavi S, Meraner P, Rao A, Hogan PG. Conformational Switching Mechanisms Underlying the Activation of Stromal Interaction Molecule 1 (STIM1) Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.257  0.306
2012 Martinez GJ, Rao A. Immunology. Cooperative transcription factor complexes in control. Science (New York, N.Y.). 338: 891-2. PMID 23161983 DOI: 10.1126/Science.1231310  0.398
2012 Huang Y, Rao A. New functions for DNA modifications by TET-JBP. Nature Structural & Molecular Biology. 19: 1061-4. PMID 23132381 DOI: 10.1038/Nsmb.2437  0.494
2012 Pastor WA, Huang Y, Henderson HR, Agarwal S, Rao A. The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols. 7: 1909-17. PMID 23018194 DOI: 10.1038/nprot.2012.104  0.758
2012 Huang Y, Pastor WA, Zepeda-Martínez JA, Rao A. The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols. 7: 1897-908. PMID 23018193 DOI: 10.1038/Nprot.2012.103  0.698
2012 Benson MJ, Aijö T, Chang X, Gagnon J, Pape UJ, Anantharaman V, Aravind L, Pursiheimo JP, Oberdoerffer S, Liu XS, Lahesmaa R, Lähdesmäki H, Rao A. Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 16252-7. PMID 22991471 DOI: 10.1073/Pnas.1214414109  0.39
2012 Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, ... ... Rao A, et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes & Development. 26: 2038-49. PMID 22925884 DOI: 10.1101/Gad.198200.112  0.331
2012 Bandukwala HS, Gagnon J, Togher S, Greenbaum JA, Lamperti ED, Parr NJ, Molesworth AM, Smithers N, Lee K, Witherington J, Tough DF, Prinjha RK, Peters B, Rao A. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 109: 14532-7. PMID 22912406 DOI: 10.1073/Pnas.1212264109  0.476
2012 Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nature Chemical Biology. 8: 311-7. PMID 22327401 DOI: 10.1038/Nchembio.790  0.305
2012 Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 36: 175-87. PMID 22326582 DOI: 10.1016/J.Immuni.2011.12.014  0.793
2012 Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R. RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Stem Cells (Dayton, Ohio). 30: 452-60. PMID 22162396 DOI: 10.1002/Stem.1013  0.357
2012 Märklin M, Bugl S, Heitmann JS, Poljak A, S B, Kopp H, Kanz L, Rao A, Wirths S, Müller MR. Genetic Loss of NFAT2 Induces Profound Acceleration of CLL in the TCL1 Mouse Model Blood. 120: 862-862. DOI: 10.1182/Blood.V120.21.862.862  0.362
2012 Quintana A, Sharma S, Findlay GM, Baust B, Jain M, Nilsson R, Mettlen M, Hogan P, Rao A. Novel Modulators of STIM-ORAI Calcium Entry Pathway Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1730  0.305
2011 Ko M, Bandukwala HS, An J, Lamperti ED, Thompson EC, Hastie R, Tsangaratou A, Rajewsky K, Koralov SB, Rao A. Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 14566-71. PMID 21873190 DOI: 10.1073/Pnas.1112317108  0.399
2011 Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood. 118: 3932-41. PMID 21828135 DOI: 10.1182/Blood-2010-10-311019  0.424
2011 Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 11381-6. PMID 21709260 DOI: 10.1073/Pnas.1019711108  0.425
2011 Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu XS, Ecker JR, Milos PM, ... ... Rao A, et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 473: 394-7. PMID 21552279 DOI: 10.1038/Nature10102  0.808
2011 Bandukwala HS, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity. 34: 479-91. PMID 21458306 DOI: 10.1016/J.Immuni.2011.02.017  0.379
2011 Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 8: 200-13. PMID 21295276 DOI: 10.1016/J.Stem.2011.01.008  0.801
2011 Li H, Rao A, Hogan PG. Interaction of calcineurin with substrates and targeting proteins. Trends in Cell Biology. 21: 91-103. PMID 21115349 DOI: 10.1016/J.Tcb.2010.09.011  0.368
2011 Rao A, Ko M, Pastor W, Huang Y. TET2: Mechanism and Functional Consequences of Hydroxymethylation Blood. 118: SCI-32-SCI-32. DOI: 10.1182/Blood.V118.21.Sci-32.Sci-32  0.718
2011 Jankowska AM, Huang Y, Ko M, Pape UJ, Makishima H, Szpurka H, Traina F, Visconte V, Tiu RV, Sekeres MA, Rao A, Maciejewski JP. Mechanisms of Defective Hydroxylation of 5-Methylcytosine in MDS Include Pathways Other Than TET2 and IDH1/2 Blood. 118: 462-462. DOI: 10.1182/Blood.V118.21.462.462  0.466
2011 Ko M, Bandukwala HS, An J, Lamperti ED, Thompson EC, Hastie R, Tsangaratou A, Rajewsky K, Koralov SB, Rao A. Tet2 Negatively Regulates Homeostasis and Differentiation of Hematopoietic Stem Cells in Mice Blood. 118: 2354-2354. DOI: 10.1182/Blood.V118.21.2354.2354  0.418
2011 Märklin M, Bugl S, Bechtel M, Poljak A, Kopp H, Kanz L, Rao A, Wirths S, Müller MR. Ca2+/NFAT Signaling Regulates the Expression CD38 and ZAP70 in Murine B Cells and Controls B1a Cell Homeostasis Blood. 118: 183-183. DOI: 10.1182/Blood.V118.21.183.183  0.38
2010 Pai BS, Agarwal S, Srinivasan G, Rao L, Rao AC. Metaplastic carcinoma breast (carcinosarcoma variant). The Indian Journal of Surgery. 72: 357-8. PMID 23133299 DOI: 10.1007/s12262-010-0104-6  0.41
2010 Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R, Liu XS, Aravind L, Agarwal S, Maciejewski JP, Rao A. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 468: 839-43. PMID 21057493 DOI: 10.1038/Nature09586  0.782
2010 Müller MR, Rao A. NFAT, immunity and cancer: a transcription factor comes of age. Nature Reviews. Immunology. 10: 645-56. PMID 20725108 DOI: 10.1038/Nri2818  0.423
2010 Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Müller MR. Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America. 107: 15169-15174. PMID 20696888 DOI: 10.1073/Pnas.1009193107  0.458
2010 Pipkin ME, Rao A, Lichtenheld MG. The transcriptional control of the perforin locus. Immunological Reviews. 235: 55-72. PMID 20536555 DOI: 10.1111/J.0105-2896.2010.00905.X  0.453
2010 Zhou Y, Ramachandran S, Oh-Hora M, Rao A, Hogan PG. Pore architecture of the ORAI1 store-operated calcium channel. Proceedings of the National Academy of Sciences of the United States of America. 107: 4896-901. PMID 20194792 DOI: 10.1073/Pnas.1001169107  0.524
2010 Huang Y, Pastor WA, Shen Y, Tahiliani M, Liu DR, Rao A. The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. Plos One. 5: e8888. PMID 20126651 DOI: 10.1371/Journal.Pone.0008888  0.781
2010 Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity. 32: 79-90. PMID 20096607 DOI: 10.1016/J.Immuni.2009.11.012  0.789
2010 Zhou Y, Meraner P, Kwon HT, Machnes D, Oh-hora M, Zimmer J, Huang Y, Stura A, Rao A, Hogan PG. STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nature Structural & Molecular Biology. 17: 112-6. PMID 20037597 DOI: 10.1038/Nsmb.1724  0.606
2010 Fehr T, Lucas CL, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A, Sykes M. A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Blood. 115: 1280-7. PMID 20007805 DOI: 10.1182/Blood-2009-07-230680  0.312
2010 Jankowska A, Makishima H, Tiu RV, Szpurka H, Huang Y, Sugimoto Y, Prince C, O'Keefe CL, Hsi E, List AF, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP. Mutational Spectrum In Chronic Myelomonocytic Leukemia Includes Genes Associated with Epigenetic Regulation Such as UTX and EZH2 Blood. 116: 611-611. DOI: 10.1182/Blood.V116.21.611.611  0.421
2010 Jankowska A, Ko M, Huang (equal contribution) Y, Pape UJ, Szpurka H, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Liu XS, Aravind L, Agarwal S, Rao A, Maciejewski JP. Impaired Hydroxylation of 5-Methylcytosine In TET2 mutated Patients with Myeloid Malignancies Blood. 116: 1-1. DOI: 10.1182/Blood.V116.21.1.1  0.796
2010 Hozumi K, Hirano K, Nakano Y, Sakai A, Habu S, Chen H, Wong N, Bunting S, Chen DJ, Chen BPC, Nussenzweig A, Sakaguchi S, Hombauer M, Bilic I, Naoe Y, ... ... Rao A, et al. T cell development (WS-058) Chairpersons: Katsuto Hozumi, Georg Holländer International Immunology. 22. DOI: 10.1093/Intimm/Dxq406  0.381
2010 Zhou Y, Meraner P, Kwon HT, Machnes D, Oh-hora M, Zimmer J, Huang Y, Stura A, Rao A, Hogan PG. Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in Vitro Biophysical Journal. 98: 97a. DOI: 10.1016/J.Bpj.2009.12.546  0.605
2009 Djuretic IM, Cruz-Guilloty F, Rao A. Regulation of gene expression in peripheral T cells by Runx transcription factors. Advances in Immunology. 104: 1-23. PMID 20457114 DOI: 10.1016/S0065-2776(08)04001-7  0.808
2009 John G, Peter JV, Chacko B, Pichamuthu K, Rao A, Subbalakshmi K, George KE, Agarwal SK, Anouncia SM, Sunderraj E, Siromoney A. A computer-assisted recording, diagnosis and management of the medically ill system for use in the intensive care unit: a preliminary report. Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine. 13: 136-42. PMID 20040810 DOI: 10.4103/0972-5229.58538  0.408
2009 McCarl CA, Picard C, Khalil S, Kawasaki T, Röther J, Papolos A, Kutok J, Hivroz C, Ledeist F, Plogmann K, Ehl S, Notheis G, Albert MH, Belohradsky BH, Kirschner J, ... Rao A, et al. ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. The Journal of Allergy and Clinical Immunology. 124: 1311-1318.e7. PMID 20004786 DOI: 10.1016/J.Jaci.2009.10.007  0.613
2009 Koh KP, Sundrud MS, Rao A. Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3. Plos One. 4: e8109. PMID 19956618 DOI: 10.1371/Journal.Pone.0008109  0.38
2009 Pipkin ME, Rao A. SnapShot: effector and memory T cell differentiation. Cell. 138: 606.e1-2. PMID 19665979 DOI: 10.1016/J.Cell.2009.07.020  0.416
2009 Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (New York, N.Y.). 324: 1334-8. PMID 19498172 DOI: 10.1126/Science.1172638  0.365
2009 Picard C, McCarl CA, Papolos A, Khalil S, Lüthy K, Hivroz C, LeDeist F, Rieux-Laucat F, Rechavi G, Rao A, Fischer A, Feske S. STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. The New England Journal of Medicine. 360: 1971-80. PMID 19420366 DOI: 10.1056/Nejmoa0900082  0.589
2009 Iyer LM, Tahiliani M, Rao A, Aravind L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (Georgetown, Tex.). 8: 1698-710. PMID 19411852 DOI: 10.4161/Cc.8.11.8580  0.769
2009 Drews-Elger K, Ortells MC, Rao A, López-Rodriguez C, Aramburu J. The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. Plos One. 4: e5245. PMID 19381288 DOI: 10.1371/Journal.Pone.0005245  0.42
2009 Oh-hora M, Rao A. The calcium/NFAT pathway: role in development and function of regulatory T cells. Microbes and Infection / Institut Pasteur. 11: 612-9. PMID 19375514 DOI: 10.1016/J.Micinf.2009.04.008  0.375
2009 Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (New York, N.Y.). 324: 930-5. PMID 19372391 DOI: 10.1126/Science.1170116  0.802
2009 Müller MR, Sasaki Y, Stevanovic I, Lamperti ED, Ghosh S, Sharma S, Gelinas C, Rossi DJ, Pipkin ME, Rajewsky K, Hogan PG, Rao A. Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 106: 7034-9. PMID 19351896 DOI: 10.1073/Pnas.0813296106  0.429
2009 Soto-Nieves N, Puga I, Abe BT, Bandyopadhyay S, Baine I, Rao A, Macian F. Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. The Journal of Experimental Medicine. 206: 867-76. PMID 19307325 DOI: 10.1084/Jem.20082731  0.46
2009 Cruz-Guilloty F, Pipkin ME, Djuretic IM, Levanon D, Lotem J, Lichtenheld MG, Groner Y, Rao A. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. The Journal of Experimental Medicine. 206: 51-9. PMID 19139168 DOI: 10.1084/Jem.20081242  0.813
2009 Mayoral RJ, Pipkin ME, Pachkov M, van Nimwegen E, Rao A, Monticelli S. MicroRNA-221-222 regulate the cell cycle in mast cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 433-45. PMID 19109175 DOI: 10.4049/Jimmunol.182.1.433  0.333
2009 Rao A. Signaling to gene expression: calcium, calcineurin and NFAT. Nature Immunology. 10: 3-5. PMID 19088731 DOI: 10.1038/Ni0109-3  0.336
2009 Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Mueller MR. Hyperactivable NFAT1 Ameliorates Autoimmune Encephalitis In Vivo. Blood. 114: 711-711. DOI: 10.1182/Blood.V114.22.711.711  0.423
2008 Puga I, Rao A, Macian F. Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity. 29: 193-204. PMID 18701083 DOI: 10.1016/J.Immuni.2008.06.010  0.42
2008 Bandukwala H, Sundrud MS, Rao A. Orphans against autoimmunity. Immunity. 29: 167-8. PMID 18701076 DOI: 10.1016/J.Immuni.2008.07.008  0.341
2008 Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (New York, N.Y.). 321: 686-91. PMID 18669861 DOI: 10.1126/Science.1157610  0.418
2008 Horng T, Oberdoerffer S, Rao A. Gene regulation and signal transduction in the immune system. Genome Biology. 9: 315. PMID 18644102 DOI: 10.1186/Gb-2008-9-7-315  0.309
2008 Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Molecular and Cellular Biology. 28: 5209-22. PMID 18591248 DOI: 10.1128/Mcb.00360-08  0.626
2008 Oh-hora M, Rao A. Calcium signaling in lymphocytes. Current Opinion in Immunology. 20: 250-8. PMID 18515054 DOI: 10.1016/J.Coi.2008.04.004  0.356
2008 Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Molecular Biology of the Cell. 19: 2802-17. PMID 18448669 DOI: 10.1091/Mbc.E08-02-0146  0.4
2008 Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nature Structural & Molecular Biology. 15: 523-30. PMID 18438418 DOI: 10.1038/Nsmb.1417  0.775
2008 Oh-Hora M, Yamashita M, Hogan PG, Sharma S, Lamperti E, Chung W, Prakriya M, Feske S, Rao A. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nature Immunology. 9: 432-43. PMID 18327260 DOI: 10.1038/Ni1574  0.647
2008 Sundrud MS, Rao A. Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore. Immunity. 28: 5-7. PMID 18199410 DOI: 10.1016/J.Immuni.2007.12.006  0.402
2008 Mueller MR, Robbs BK, Cruz AL, Sasaki Y, Stevanovic I, Rajewsky K, Viola JP, Rao A. Evidence for NFAT1 as a Tumor Suppressor in T-ALL Blood. 112: 3804-3804. DOI: 10.1182/Blood.V112.11.3804.3804  0.454
2008 Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Erratum: Corrigendum: Gene regulation mediated by calcium signals in T lymphocytes Nature Immunology. 9: 328-329. DOI: 10.1038/Ni0308-328  0.593
2007 Carvalho LD, Teixeira LK, Carrossini N, Caldeira AT, Ansel KM, Rao A, Viola JP. The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle (Georgetown, Tex.). 6: 1789-95. PMID 17637565 DOI: 10.4161/Cc.6.14.4473  0.383
2007 Hu H, Djuretic I, Sundrud MS, Rao A. Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT. Trends in Immunology. 28: 329-32. PMID 17618833 DOI: 10.1016/J.It.2007.06.006  0.809
2007 Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 42: 145-56. PMID 17572487 DOI: 10.1016/J.Ceca.2007.03.007  0.651
2007 Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A, Shi Y. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature. 447: 601-5. PMID 17468742 DOI: 10.1038/Nature05823  0.776
2007 Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science (New York, N.Y.). 316: 604-8. PMID 17463289 DOI: 10.1126/Science.1141229  0.344
2007 Sundrud MS, Rao A. New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT. Current Opinion in Immunology. 19: 287-93. PMID 17433870 DOI: 10.1016/J.Coi.2007.04.014  0.428
2007 Sundrud MS, Rao A. Regulatory T-cell gene expression: ChIP'ing away at Foxp3. Immunology and Cell Biology. 85: 177-8. PMID 17353928 DOI: 10.1038/Sj.Icb.7100051  0.425
2007 Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins. The Journal of Biological Chemistry. 282: 16232-43. PMID 17293345 DOI: 10.1074/Jbc.M609630200  0.798
2007 Pipkin ME, Ljutic B, Cruz-Guilloty F, Nouzova M, Rao A, Zúñiga-Pflücker JC, Lichtenheld MG. Chromosome transfer activates and delineates a locus control region for perforin. Immunity. 26: 29-41. PMID 17222571 DOI: 10.1016/J.Immuni.2006.11.009  0.784
2007 Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nature Immunology. 8: 145-53. PMID 17195845 DOI: 10.1038/Ni1424  0.807
2007 Mueller MR, Sasaki Y, Sharma S, Ghosh S, Gelinas C, Lamperti EL, Rajewsky K, Rao A. Expression of Hyperactivable NFAT1 from the ROSA26 Locus Leads to Detrimental Effects during Embryonic Development. Blood. 110: 2296-2296. DOI: 10.1182/Blood.V110.11.2296.2296  0.414
2007 Feske S, Rao A, Hogan PG. The Ca2+–calcineurin–NFAT signalling pathway New Comprehensive Biochemistry. 41: 365-401. DOI: 10.1016/S0167-7306(06)41014-0  0.621
2006 Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature. 443: 230-3. PMID 16921383 DOI: 10.1038/Nature05122  0.593
2006 Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 126: 375-87. PMID 16873067 DOI: 10.1016/J.Cell.2006.05.042  0.752
2006 Barrington RA, Borde M, Rao A, Carroll MC. Involvement of NFAT1 in B cell self-tolerance. Journal of Immunology (Baltimore, Md. : 1950). 177: 1510-5. PMID 16849457 DOI: 10.4049/Jimmunol.177.3.1510  0.673
2006 Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, Tucker PW, Rao A. Foxp1 is an essential transcriptional regulator of B cell development. Nature Immunology. 7: 819-26. PMID 16819554 DOI: 10.1038/Ni1358  0.708
2006 Borde M, Barrington RA, Heissmeyer V, Carroll MC, Rao A. Transcriptional basis of lymphocyte tolerance. Immunological Reviews. 210: 105-19. PMID 16623767 DOI: 10.1111/J.0105-2896.2006.00370.X  0.725
2006 Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 441: 179-85. PMID 16582901 DOI: 10.1038/Nature04702  0.624
2006 Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annual Review of Immunology. 24: 607-56. PMID 16551261 DOI: 10.1146/Annurev.Immunol.23.021704.115821  0.805
2006 Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 441: 646-50. PMID 16511445 DOI: 10.1038/Nature04631  0.618
2006 Mueller MR, Sasaki Y, Sharma S, Rajewsky K, Rao A. The Role of the Transcription Factor NFAT in the Pathogenesis of Non-Hodgkin’s Lymphomas. Blood. 108: 2371-2371. DOI: 10.1182/Blood.V108.11.2371.2371  0.4
2005 Monticelli S, Ansel KM, Lee DU, Rao A. Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes. Novartis Foundation Symposium. 271: 179-87; discussion 1. PMID 16605135 DOI: 10.1002/9780470033449.Ch14  0.412
2005 Kumar L, Feske S, Rao A, Geha RS. A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Proceedings of the National Academy of Sciences of the United States of America. 102: 19063-8. PMID 16354835 DOI: 10.1073/Pnas.0509176102  0.661
2005 Monticelli S, Lee DU, Nardone J, Bolton DL, Rao A. Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells. International Immunology. 17: 1513-24. PMID 16199489 DOI: 10.1093/Intimm/Dxh329  0.404
2005 Feske S, Prakriya M, Rao A, Lewis RS. A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. The Journal of Experimental Medicine. 202: 651-62. PMID 16147976 DOI: 10.1084/Jem.20050687  0.612
2005 Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. MicroRNA profiling of the murine hematopoietic system. Genome Biology. 6: R71. PMID 16086853 DOI: 10.1186/Gb-2005-6-8-R71  0.32
2005 Esensten JH, Tsytsykova AV, Lopez-Rodriguez C, Ligeiro FA, Rao A, Goldfeld AE. NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone. Nucleic Acids Research. 33: 3845-54. PMID 16027109 DOI: 10.1093/Nar/Gki701  0.398
2005 Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K. Aberrant T cell differentiation in the absence of Dicer. The Journal of Experimental Medicine. 202: 261-9. PMID 16009718 DOI: 10.1084/Jem.20050678  0.442
2005 Heissmeyer V, Macián F, Varma R, Im SH, García-Cozar F, Horton HF, Byrne MC, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A. A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling. Novartis Foundation Symposium. 267: 165-74; discussion 1. PMID 15999806  0.626
2005 Bix M, Kim S, Rao A. Immunology. Opposites attract in differentiating T cells. Science (New York, N.Y.). 308: 1563-5. PMID 15947163 DOI: 10.1126/Science.1114167  0.39
2005 Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages Molecular and Cellular Biology. 25: 3896-3905. PMID 15870264 DOI: 10.1128/Mcb.25.10.3896-3905.2005  0.336
2005 Heissmeyer V, Macián F, Varma R, Im SH, García-Cozar F, Horton HF, Byrne MC, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A. A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling. Novartis Foundation Symposium. 267: 165-174. DOI: 10.1002/047002139X.Ch11  0.661
2004 Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nature Immunology. 5: 1251-9. PMID 15516924 DOI: 10.1038/Ni1135  0.814
2004 Li H, Rao A, Hogan PG. Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions. Journal of Molecular Biology. 342: 1659-74. PMID 15364589 DOI: 10.1016/J.Jmb.2004.07.068  0.323
2004 Im SH, Hueber A, Monticelli S, Kang KH, Rao A. Chromatin-level regulation of the IL10 gene in T cells. The Journal of Biological Chemistry. 279: 46818-25. PMID 15319439 DOI: 10.1074/Jbc.M401722200  0.441
2004 Nardone J, Lee DU, Ansel KM, Rao A. Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nature Immunology. 5: 768-74. PMID 15282556 DOI: 10.1038/Ni0804-768  0.31
2004 Heissmeyer V, Rao A. E3 ligases in T cell anergy--turning immune responses into tolerance. Science Signaling. 2004. PMID 15252218 DOI: 10.1126/Stke.2412004Pe29  0.435
2004 Monticelli S, Solymar DC, Rao A. Role of NFAT proteins in IL13 gene transcription in mast cells. The Journal of Biological Chemistry. 279: 36210-8. PMID 15229217 DOI: 10.1074/Jbc.M406354200  0.804
2004 Roehrl MH, Kang S, Aramburu J, Wagner G, Rao A, Hogan PG. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proceedings of the National Academy of Sciences of the United States of America. 101: 7554-9. PMID 15131267 DOI: 10.1073/Pnas.0401835101  0.308
2004 Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A. A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Molecular and Cellular Biology. 24: 4184-95. PMID 15121840 DOI: 10.1128/Mcb.24.10.4184-4195.2004  0.348
2004 Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Molecular and Cellular Biology. 24: 3860-73. PMID 15082780 DOI: 10.1128/Mcb.24.9.3860-3873.2004  0.412
2004 Macián F, Im SH, García-Cózar FJ, Rao A. T-cell anergy. Current Opinion in Immunology. 16: 209-16. PMID 15023415 DOI: 10.1016/J.Coi.2004.01.013  0.41
2004 López-Rodríguez C, Antos CL, Shelton JM, Richardson JA, Lin F, Novobrantseva TI, Bronson RT, Igarashi P, Rao A, Olson EN. Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proceedings of the National Academy of Sciences of the United States of America. 101: 2392-7. PMID 14983020 DOI: 10.1073/Pnas.0308703100  0.388
2004 Heissmeyer V, Macián F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nature Immunology. 5: 255-65. PMID 14973438 DOI: 10.1038/Ni1047  0.671
2004 Lee DU, Avni O, Chen L, Rao A. A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison Journal of Biological Chemistry. 279: 4802-4810. PMID 14607827 DOI: 10.1074/Jbc.M307904200  0.449
2003 Feske S, Okamura H, Hogan PG, Rao A. Ca2+/calcineurin signalling in cells of the immune system. Biochemical and Biophysical Research Communications. 311: 1117-32. PMID 14623298 DOI: 10.1016/J.Bbrc.2003.09.174  0.601
2003 Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes & Development. 17: 2205-32. PMID 12975316 DOI: 10.1101/Gad.1102703  0.356
2003 Jin L, Sliz P, Chen L, Macián F, Rao A, Hogan PG, Harrison SC. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nature Structural Biology. 10: 807-11. PMID 12949491 DOI: 10.1038/Nsb975  0.301
2003 Syken J, Macian F, Agarwal S, Rao A, Münger K. TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells. Oncogene. 22: 4636-41. PMID 12879007 DOI: 10.1038/Sj.Onc.1206569  0.609
2003 Ansel KM, Lee DU, Rao A. An epigenetic view of helper T cell differentiation. Nature Immunology. 4: 616-23. PMID 12830136 DOI: 10.1038/Ni0703-616  0.469
2002 Monticelli S, Rao A. NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription. European Journal of Immunology. 32: 2971-2978. PMID 12355451 DOI: 10.1002/1521-4141(2002010)32:10<2971::Aid-Immu2971>3.0.Co;2-G  0.467
2002 Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 17: 41-50. PMID 12150890 DOI: 10.1016/S1074-7613(02)00334-5  0.803
2002 Macián F, García-Cózar F, Im SH, Horton HF, Byrne MC, Rao A. Transcriptional mechanisms underlying lymphocyte tolerance. Cell. 109: 719-31. PMID 12086671 DOI: 10.1016/S0092-8674(02)00767-5  0.42
2002 Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nature Cell Biology. 4: 540-4. PMID 12080349 DOI: 10.1038/Ncb816  0.308
2002 Avni O, Lee D, Macian F, Szabo SJ, Glimcher LH, Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nature Immunology. 3: 643-51. PMID 12055628 DOI: 10.1038/Ni808  0.465
2002 Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity. 16: 649-60. PMID 12049717 DOI: 10.1016/S1074-7613(02)00314-X  0.642
2002 Stroud JC, Lopez-Rodriguez C, Rao A, Chen L. Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor. Nature Structural Biology. 9: 90-4. PMID 11780147 DOI: 10.1038/Nsb749  0.38
2001 Agarwal A, Shen H, Agarwal S, Rao AV. Lycopene Content of Tomato Products: Its Stability, Bioavailability and In Vivo Antioxidant Properties. Journal of Medicinal Food. 4: 9-15. PMID 12639283 DOI: 10.1089/10966200152053668  0.445
2001 Rao A. New functions for DNA binding domains Science"S Stke [Electronic Resource] : Signal Transduction Knowledge Environment. 2001. PMID 11752650 DOI: 10.1126/Stke.2001.81.Pe1  0.347
2001 Kiani A, Garcia-Cozar FJ, Habermann I, Laforsch S, Aebischer T, Ehninger G, Rao A. Regulation of interferon-gamma gene expression by nuclear factor of activated T cells. Blood. 98: 1480-1488. PMID 11520798 DOI: 10.1182/Blood.V98.5.1480  0.473
2001 López-Rodríguez C, Aramburu J, Jin L, Rakeman AS, Michino M, Rao A. Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity. 15: 47-58. PMID 11485737 DOI: 10.1016/S1074-7613(01)00165-0  0.406
2001 Macián F, López-Rodríguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene. 20: 2476-2489. PMID 11402342 DOI: 10.1038/Sj.Onc.1204386  0.39
2001 Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Gene regulation mediated by calcium signals in T lymphocytes Nature Immunology. 2: 316-324. PMID 11276202 DOI: 10.1038/86318  0.681
2001 Okamura H, Rao A. Transcriptional regulation in lymphocytes. Current Opinion in Cell Biology. 13: 239-243. PMID 11248559 DOI: 10.1016/S0955-0674(00)00203-9  0.429
2001 Feske S, Draeger R, Peter HH, Rao A. Impaired NFAT regulation and its role in a severe combined immunodeficiency. Immunobiology. 202: 134-50. PMID 10993288 DOI: 10.1016/S0171-2985(00)80060-1  0.691
2000 Rao AV, Shen H, Agarwal A, Yatcilla MT, Agarwal S. Bioabsorption and in vivo antioxidant properties of grape extract biovin((r)): a human intervention study. Journal of Medicinal Food. 3: 15-22. PMID 19281340 DOI: 10.1089/jmf.2000.3.15  0.456
2000 Agarwal S, Rao AV. Carotenoids and chronic diseases. Drug Metabolism and Drug Interactions. 17: 189-210. PMID 11201295  0.428
2000 Avni O, Rao A. T cell differentiation: A mechanistic view Current Opinion in Immunology. 12: 654-659. PMID 11102768 DOI: 10.1016/S0952-7915(00)00158-8  0.472
2000 Jenkins DJ, Kendall CW, Vidgen E, Vuksan V, Jackson CJ, Augustin LS, Lee B, Garsetti M, Agarwal S, Rao AV, Cagampang GB, Fulgoni V. Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein. Metabolism: Clinical and Experimental. 49: 1496-500. PMID 11092518 DOI: 10.1053/meta.2000.17703  0.443
2000 Okamura H, Aramburu J, García-Rodríguez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Molecular Cell. 6: 539-50. PMID 11030334 DOI: 10.1016/S1097-2765(00)00053-8  0.774
2000 Rao AV, Agarwal S. Role of antioxidant lycopene in cancer and heart disease. Journal of the American College of Nutrition. 19: 563-9. PMID 11022869  0.458
2000 Agarwal S, Rao AV. Tomato lycopene and its role in human health and chronic diseases. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 163: 739-44. PMID 11022591  0.449
2000 Macián F, García-Rodríguez C, Rao A. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. The Embo Journal. 19: 4783-95. PMID 10970869 DOI: 10.1093/Emboj/19.17.4783  0.443
2000 García-Rodríguez C, Rao A. Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1. European Journal of Immunology. 30: 2432-2436. PMID 10940935 DOI: 10.1002/1521-4141(2000)30:8<2432::Aid-Immu2432>3.0.Co;2-F  0.34
2000 Agarwal S, Avni O, Rao A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity. 12: 643-52. PMID 10894164 DOI: 10.1016/S1074-7613(00)80215-0  0.637
2000 Feske S, Draeger R, Peter HH, Eichmann K, Rao A. The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 297-305. PMID 10861065 DOI: 10.4049/Jimmunol.165.1.297  0.692
2000 Aramburu J, Rao A, Klee CB. Calcineurin: from structure to function. Current Topics in Cellular Regulation. 36: 237-95. PMID 10842755 DOI: 10.1016/S0070-2137(01)80011-X  0.409
2000 Jenkins DJ, Kendall CW, Garsetti M, Rosenberg-Zand RS, Jackson CJ, Agarwal S, Rao AV, Diamandis EP, Parker T, Faulkner D, Vuksan V, Vidgen E. Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity--a controlled crossover trial. Metabolism: Clinical and Experimental. 49: 537-43. PMID 10778882 DOI: 10.1016/S0026-0495(00)80022-0  0.454
2000 Jenkins DJ, Kendall CW, Vidgen E, Mehling CC, Parker T, Seyler H, Faulkner D, Garsetti M, Griffin LC, Agarwal S, Rao AV, Cunnane SC, Ryan MA, Connelly PW, Leiter LA, et al. The effect on serum lipids and oxidized low-density lipoprotein of supplementing self-selected low-fat diets with soluble-fiber, soy, and vegetable protein foods. Metabolism: Clinical and Experimental. 49: 67-72. PMID 10647066 DOI: 10.1016/S0026-0495(00)90738-8  0.437
1999 Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (New York, N.Y.). 285: 2129-33. PMID 10497131 DOI: 10.1126/Science.285.5436.2129  0.49
1999 Jenkins DJ, Kendall CW, Mehling CC, Parker T, Rao AV, Agarwal S, Novokmet R, Jones PJ, Raeini M, Story JA, Furumoto E, Vidgen E, Griffin LC, Cunnane SC, Ryan MA, et al. Combined effect of vegetable protein (soy) and soluble fiber added to a standard cholesterol-lowering diet. Metabolism: Clinical and Experimental. 48: 809-16. PMID 10381159 DOI: 10.1016/S0026-0495(99)90184-1  0.436
1999 Lopez-Rodríguez C, Aramburu J, Rakeman AS, Rao A. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proceedings of the National Academy of Sciences of the United States of America. 96: 7214-9. PMID 10377394 DOI: 10.1073/Pnas.96.13.7214  0.396
1999 Hecht SS, Kenney PM, Wang M, Trushin N, Agarwal S, Rao AV, Upadhyaya P. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Letters. 137: 123-30. PMID 10374832 DOI: 10.1016/S0304-3835(98)00326-7  0.436
1999 Rao AV, Fleshner N, Agarwal S. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study. Nutrition and Cancer. 33: 159-64. PMID 10368811 DOI: 10.1207/S15327914NC330207  0.441
1999 Agarwal S, Viola JP, Rao A. Chromatin-based regulatory mechanisms governing cytokine gene transcription. The Journal of Allergy and Clinical Immunology. 103: 990-9. PMID 10359875 DOI: 10.1016/S0091-6749(99)70168-5  0.671
1999 Viola JPB, Rao A. Molecular regulation of cytokine gene expression during the immune response Journal of Clinical Immunology. 19: 98-108. PMID 10226884 DOI: 10.1023/A:1020502516196  0.404
1999 Macián F, Rao A. Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1. Molecular and Cellular Biology. 19: 3645-53. PMID 10207088 DOI: 10.1128/Mcb.19.5.3645  0.33
1999 Hogan PG, Rao A. Transcriptional regulation. Modification by nuclear export Nature. 398: 200-201. PMID 10094042 DOI: 10.1038/18327  0.337
1999 Jenkins DJ, Kendall CW, Vidgen E, Agarwal S, Rao AV, Rosenberg RS, Diamandis EP, Novokmet R, Mehling CC, Perera T, Griffin LC, Cunnane SC. Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial. The American Journal of Clinical Nutrition. 69: 395-402. PMID 10075322 DOI: 10.1093/Ajcn/69.3.395  0.438
1998 Agarwal S, Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity. 9: 765-75. PMID 9881967 DOI: 10.1016/S1074-7613(00)80642-1  0.65
1998 Agarwal S, Rao AV. Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Lipids. 33: 981-4. PMID 9832077  0.441
1998 Rao AV, Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutrition and Cancer. 31: 199-203. PMID 9795972 DOI: 10.1080/01635589809514703  0.486
1998 Garcia-Cozar FJ, Okamura H, Aramburu JF, Shaw KTY, Pelletier L, Showalter R, Villafranca E, Rao A. Two-site Interaction of Nuclear Factor of Activated T Cells with Activated Calcineurin Journal of Biological Chemistry. 273: 23877-23883. PMID 9727000 DOI: 10.1074/Jbc.273.37.23877  0.353
1998 Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Molecular Cell. 1: 627-37. PMID 9660947 DOI: 10.1016/S1097-2765(00)80063-5  0.332
1998 Agarwal S, Rao A. Long-range transcriptional regulation of cytokine gene expression. Current Opinion in Immunology. 10: 345-52. PMID 9638372 DOI: 10.1016/S0952-7915(98)80174-X  0.611
1998 García-Rodríguez C, Rao A. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). Journal of Experimental Medicine. 187: 2031-2036. PMID 9625762 DOI: 10.1084/Jem.187.12.2031  0.411
1998 Chen L, Glover JNM, Hogan PG, Rao A, Harrison SC. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA Nature. 392: 42-48. PMID 9510247 DOI: 10.1038/32100  0.37
1998 Viola JPB, Kiani A, Bozza PT, Rao A. Regulation of allergic inflammation and eosinophil recruitment in mice lacking the transcription factor NFAT1: role of interleukin-4 (IL-4) and IL-5. Blood. 91: 2223-2230. DOI: 10.1182/Blood.V91.7.2223.2223_2223_2230  0.405
1997 Viola JPB, Rao A. Role of the Cyclosporin-sensitive Transcription Factor NFAT1 in the Allergic Response Memorias Do Instituto Oswaldo Cruz. 92: 147-155. PMID 9698927 DOI: 10.1590/S0074-02761997000800020  0.413
1997 Kiani A, Viola JP, Lichtman AH, Rao A. Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity. 7: 849-60. PMID 9430230 DOI: 10.1016/S1074-7613(00)80403-3  0.466
1997 Rao A, Luo C, Hogan PG. TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function Annual Review of Immunology. 15: 707-747. PMID 9143705 DOI: 10.1146/Annurev.Immunol.15.1.707  0.427
1997 Luo C, Copeland NG, Jenkins NA, Edelhoff S, Disteche C, Hogan PG, Rao A. Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene. Gene. 180: 29-36. PMID 8973343 DOI: 10.1016/S0378-1119(96)00396-4  0.399
1996 Luo C, Shaw KT, Raghavan A, Aramburu J, Garcia-Cozar F, Perrino BA, Hogan PG, Rao A. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proceedings of the National Academy of Sciences of the United States of America. 93: 8907-12. PMID 8799126 DOI: 10.1073/Pnas.93.17.8907  0.376
1996 Luo C, Burgeon E, Rao A. Mechanisms of transactivation by nuclear factor of activated T cells-1. Journal of Experimental Medicine. 184: 141-147. PMID 8691127 DOI: 10.1084/Jem.184.1.141  0.427
1996 Loh C, Shaw KTY, Carew J, Viola JPB, Luo C, Perrino BA, Rao A. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity Journal of Biological Chemistry. 271: 10884-10891. PMID 8631904 DOI: 10.1074/Jbc.271.18.10884  0.408
1996 Xanthoudakis S, Viola JP, Shaw KT, Luo C, Wallace JD, Bozza PT, Luk DC, Curran T, Rao A. An enhanced immune response in mice lacking the transcription factor NFAT1. Science (New York, N.Y.). 272: 892-5. PMID 8629027 DOI: 10.1126/Science.272.5263.892  0.361
1996 Tsai EY, Jain J, Pesavento PA, Rao A, Goldfeld AE. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Molecular and Cellular Biology. 16: 459-67. PMID 8552071 DOI: 10.1128/Mcb.16.2.459  0.396
1995 Rao A. NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction Journal of Leukocyte Biology. 57: 536-542. PMID 7722411  0.313
1995 Park J, Yaseen NR, Hogan PG, Rao A, Sharma S. Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells Journal of Biological Chemistry. 270: 20653-20659. PMID 7657645 DOI: 10.1074/Jbc.270.35.20653  0.424
1995 Chen L, Oakley MG, Glover JN, Jain J, Dervan PB, Hogan PG, Rao A, Verdine GL. Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp. Current Biology : Cb. 5: 882-9. PMID 7583146 DOI: 10.1016/S0960-9822(95)00178-3  0.374
1995 Jain J, Loh C, Rao A. Transcriptional regulation of the IL-2 gene. Current Opinion in Immunology. 7: 333-342. PMID 7546397 DOI: 10.1016/0952-7915(95)80107-3  0.381
1995 Wang DZ, McCAFFREY PG, Rao A. The Cyclosporin‐sensitive Transcription Factor NFATp Is Expressed in Several Classes of Cells in the Immune Systema Annals of the New York Academy of Sciences. 766: 182-194. PMID 7486655 DOI: 10.1111/J.1749-6632.1995.Tb26661.X  0.358
1995 Shaw KT, Ho AM, Raghavan A, Kim J, Jain J, Park J, Sharma S, Rao A, Hogan PG. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 11205-9. PMID 7479966 DOI: 10.1073/Pnas.92.24.11205  0.455
1995 Jain J, Burgeon E, Badalian TM, Hogan PG, Rao A. A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region Journal of Biological Chemistry. 270: 4138-4145. DOI: 10.1074/Jbc.270.8.4138  0.347
1994 Jain J, Nalefski EA, McCaffrey PG, Johnson RS, Spiegelman BM, Papaioannou V, Rao A. Normal peripheral T-cell function in c-Fos-deficient mice. Molecular and Cellular Biology. 14: 1566-74. PMID 8114694 DOI: 10.1128/Mcb.14.3.1566  0.442
1994 Goldfeld AE, Tsai E, Kincaid R, Belshaw PJ, Schrieber SL, Strominger JL, Rao A. Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells. The Journal of Experimental Medicine. 180: 763-8. PMID 8046352 DOI: 10.1084/Jem.180.2.763  0.357
1994 McCaffrey PG, Kim PK, Valge-Archer VE, Sen R, Rao A. Cyclosporin A sensitivity of the NF-κB site of the IL2Rα promoter in untransformed murine T cells Nucleic Acids Research. 22: 2134-2142. PMID 8029023 DOI: 10.1093/Nar/22.11.2134  0.359
1993 Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature. 365: 352-5. PMID 8397339 DOI: 10.1038/365352A0  0.465
1993 Goldfeld AE, McCaffrey PG, Strominger JL, Rao A. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter. The Journal of Experimental Medicine. 178: 1365-79. PMID 8376940 DOI: 10.1084/Jem.178.4.1365  0.394
1992 Jain J, Valge-Archer VE, Sinskey AJ, Rao A. The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter. Journal of Experimental Medicine. 175: 853-862. PMID 1740667 DOI: 10.1084/Jem.175.3.853  0.415
1992 Nalefski EA, Kasibhatla S, Rao A. Functional analysis of the antigen binding site on the T cell receptor alpha chain. The Journal of Experimental Medicine. 175: 1553-63. PMID 1588281 DOI: 10.1084/Jem.175.6.1553  0.3
1992 Jain J, McCaffrey PG, Valge-Archer VE, Rao A. Nuclear factor of activated T cells contains Fos and Jun Nature. 356: 801-804. PMID 1533441 DOI: 10.1038/356801A0  0.388
1988 Valge VE, Wong JGP, Datlof BM, Sinskey AJ, Rao A. Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells Cell. 55: 101-112. PMID 3262423 DOI: 10.1016/0092-8674(88)90013-X  0.403
1988 Tan KN, Datlof BM, Gilmore JA, Kronman AC, Lee JH, Maxam AM, Rao A. The T cell receptor Vα3 gene segment is associated with reactivity to p-azobenzenearsonate Cell. 54: 247-261. PMID 3260539 DOI: 10.1016/0092-8674(88)90557-0  0.382
1985 Friedman S, Sillcocks D, Rao A, Faas S, Cantor H. A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion. The Journal of Experimental Medicine. 161: 785-804. PMID 2580039 DOI: 10.1084/Jem.161.4.785  0.614
1984 Rao A, Ko WW, Faas SJ, Cantor H. Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T-cell clones. Cell. 36: 879-88. PMID 6608410 DOI: 10.1016/0092-8674(84)90037-0  0.579
1984 Rao A, Faas SJ, Cantor H. Analogs that compete for antigen binding to an arsonate-reactive T-cell clone inhibit the functional response to arsonate Cell. 36: 889-895. PMID 6423288 DOI: 10.1016/0092-8674(84)90038-2  0.584
1984 Rao A, Faas SJ, Cantor H. Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies. The Journal of Experimental Medicine. 159: 479-94. PMID 6198431 DOI: 10.1084/Jem.159.2.479  0.599
1983 Rao A, Allard WJ, Hogan PG, Rosenson RS, Cantor H. Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products. Immunogenetics. 17: 147-65. PMID 6600709 DOI: 10.1007/Bf00364755  0.594
1983 Rao A, Faas SJ, Miller LJ, Riback PS, Cantor H. Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines. The Journal of Experimental Medicine. 158: 1243-58. PMID 6194244 DOI: 10.1084/Jem.158.4.1243  0.621
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