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Qing-Yu Zhang - Publications

Affiliations: 
Environmental Health Sciences State University of New York, Albany, Albany, NY, United States 
Area:
Toxicology, Pharmacology, Public Health, Biochemistry
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kovalchuk N, Zhang QY, Van Winkle L, Ding X. Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32974682 DOI: 10.1093/Toxsci/Kfaa114  0.336
2020 Fan X, Ding X, Zhang QY. Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model. Acta Pharmaceutica Sinica. B. 10: 123-135. PMID 31993311 DOI: 10.1016/J.Apsb.2019.12.002  0.328
2019 Kovalchuk N, Zhang QY, Kelty J, Van Winkle LS, Ding X. Toxicokinetic interaction between hepatic disposition and pulmonary bioactivation of inhaled naphthalene studied using Cyp2abfgs-null and CYP2A13/2F1-humanized mice with deficient hepatic cytochrome P450 activity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31594800 DOI: 10.1124/Dmd.119.088930  0.393
2019 Fan X, Li H, Ding X, Zhang QY. Contributions of Hepatic and Intestinal Metabolism to the Disposition of Niclosamide, A Repurposed Drug with Poor Bioavailability. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31040114 DOI: 10.1124/Dmd.119.086678  0.426
2019 Jia K, Zhang D, Jia Q, Zhang QY. Regulation of Fgf15 expression in the intestine by glucocorticoid receptor. Molecular Medicine Reports. PMID 30720089 DOI: 10.3892/Mmr.2019.9915  0.313
2018 Bissig KD, Han W, Barzi M, Kovalchuk N, Ding L, Fan X, Pankowicz F, Zhang QY, Ding X. CYP-humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30093418 DOI: 10.1124/Dmd.118.083303  0.331
2018 Li L, Zhang QY, Ding X. A CYP2B6-humanized mouse model and its potential applications. Drug Metabolism and Pharmacokinetics. PMID 29402634 DOI: 10.1016/J.Dmpk.2018.01.001  0.397
2016 Xie F, Ding X, Zhang QY. An update on the role of intestinal cytochrome P450 enzymes in drug disposition. Acta Pharmaceutica Sinica. B. 6: 374-383. PMID 27709006 DOI: 10.1016/J.Apsb.2016.07.012  0.377
2015 Turesky RJ, Konorev D, Fan X, Tang Y, Yao L, Ding X, Xie F, Zhu Y, Zhang QY. The Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-Pyrido[2,3-b]Indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice. Chemical Research in Toxicology. PMID 26583703 DOI: 10.1021/Acs.Chemrestox.5B00405  0.31
2015 Zhu Y, Xie F, Ding L, Fan X, Ding X, Zhang QY. Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis. The Journal of Pharmacology and Experimental Therapeutics. 354: 10-7. PMID 25926522 DOI: 10.1124/Jpet.115.223263  0.397
2015 Liu Z, Li L, Wu H, Hu J, Ma J, Zhang QY, Ding X. Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 208-16. PMID 25409894 DOI: 10.1124/Dmd.114.061812  0.423
2014 Ahlawat S, Xie F, Zhu Y, D'Hondt R, Ding X, Zhang QY, Mantis NJ. Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage. Scientific Reports. 4: 5551. PMID 24989705 DOI: 10.1038/Srep05551  0.413
2014 Jia K, Li L, Liu Z, Hartog M, Kluetzman K, Zhang QY, Ding X. Generation and characterization of a novel CYP2A13--transgenic mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1341-8. PMID 24907355 DOI: 10.1124/Dmd.114.059188  0.384
2014 Megaraj V, Ding X, Fang C, Kovalchuk N, Zhu Y, Zhang QY. Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice. Chemical Research in Toxicology. 27: 656-62. PMID 24552495 DOI: 10.1021/Tx4004769  0.42
2014 Zhu Y, Ding X, Fang C, Zhang QY. Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure. Molecular Pharmacology. 85: 139-47. PMID 24184963 DOI: 10.1124/Mol.113.088914  0.359
2013 Zhang P, Jia K, Fang C, Zhou X, Ding X, Zhang QY. Dietary regulation of mouse intestinal P450 expression and drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 529-35. PMID 23160819 DOI: 10.1124/Dmd.112.049403  0.435
2013 Riddick DS, Ding X, Wolf CR, Porter TD, Pandey AV, Zhang QY, Gu J, Finn RD, Ronseaux S, McLaughlin LA, Henderson CJ, Zou L, Flück CE. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 12-23. PMID 23086197 DOI: 10.1124/Dmd.112.048991  0.402
2013 Wei Y, Li L, Zhou X, Zhang QY, Dunbar A, Liu F, Kluetzman K, Yang W, Ding X. Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 132-40. PMID 23073733 DOI: 10.1124/Dmd.112.048736  0.439
2012 Zhu Y, Zhang QY. Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine. The Journal of Pharmacology and Experimental Therapeutics. 343: 362-70. PMID 22892338 DOI: 10.1124/Jpet.112.198077  0.414
2012 D'Agostino J, Ding X, Zhang P, Jia K, Fang C, Zhu Y, Spink DC, Zhang QY. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. The Journal of Biological Chemistry. 287: 17777-88. PMID 22453923 DOI: 10.1074/Jbc.M112.354274  0.395
2012 Wei Y, Wu H, Li L, Liu Z, Zhou X, Zhang QY, Weng Y, D'Agostino J, Ling G, Zhang X, Kluetzman K, Yao Y, Ding X. Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1144-50. PMID 22397853 DOI: 10.1124/Dmd.112.044826  0.322
2011 Zhu Y, D'Agostino J, Zhang QY. Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 939-43. PMID 21349922 DOI: 10.1124/Dmd.110.037861  0.391
2010 Wei Y, Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X. Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. The Journal of Pharmacology and Experimental Therapeutics. 334: 69-77. PMID 20375200 DOI: 10.1124/Jpet.110.167411  0.409
2009 Zhang QY, Fang C, Zhang J, Dunbar D, Kaminsky L, Ding X. An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 651-7. PMID 19056912 DOI: 10.1124/Dmd.108.025429  0.448
2007 Zhang QY, Kaminsky LS, Dunbar D, Zhang J, Ding X. Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1617-23. PMID 17567730 DOI: 10.1124/Dmd.107.016543  0.439
2005 Zhang QY, Gu J, Su T, Cui H, Zhang X, D'Agostino J, Zhuo X, Yang W, Swiatek PJ, Ding X. Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. Biochemical and Biophysical Research Communications. 338: 318-24. PMID 16126166 DOI: 10.1016/J.Bbrc.2005.08.086  0.347
2005 Zhang X, Zhang QY, Liu D, Su T, Weng Y, Ling G, Chen Y, Gu J, Schilling B, Ding X. Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1423-8. PMID 16014766 DOI: 10.1124/Dmd.105.005769  0.379
2005 Gu J, Cui H, Behr M, Zhang L, Zhang QY, Yang W, Hinson JA, Ding X. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Molecular Pharmacology. 67: 623-30. PMID 15550675 DOI: 10.1124/Mol.104.007898  0.422
2005 Wu L, Gu J, Cui H, Zhang QY, Behr M, Fang C, Weng Y, Kluetzman K, Swiatek PJ, Yang W, Kaminsky L, Ding X. Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450. The Journal of Pharmacology and Experimental Therapeutics. 312: 35-43. PMID 15328377 DOI: 10.1124/Jpet.104.073353  0.437
2004 Zhuo X, Gu J, Behr MJ, Swiatek PJ, Cui H, Zhang QY, Xie Y, Collins DN, Ding X. Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression. The Journal of Pharmacology and Experimental Therapeutics. 308: 719-28. PMID 14610229 DOI: 10.1124/Jpet.103.060301  0.345
2003 Zhang QY, Dunbar D, Kaminsky LS. Characterization of mouse small intestinal cytochrome P450 expression. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1346-51. PMID 14570766 DOI: 10.1124/Dmd.31.11.1346  0.37
2003 Chen Y, Liu YQ, Su T, Ren X, Shi L, Liu D, Gu J, Zhang QY, Ding X. Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa. Biochemical Pharmacology. 66: 1245-51. PMID 14505803 DOI: 10.1016/S0006-2952(03)00476-3  0.326
2003 Wu L, Gu J, Weng Y, Kluetzman K, Swiatek P, Behr M, Zhang QY, Zhuo X, Xie Q, Ding X. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis (New York, N.Y. : 2000). 36: 177-81. PMID 12929087 DOI: 10.1002/Gene.10214  0.43
2003 Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, Ding X. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. The Journal of Biological Chemistry. 278: 25895-901. PMID 12697746 DOI: 10.1074/Jbc.M303125200  0.42
2002 Su T, Zhang QY, Zhang J, Swiatek P, Ding X. Expression of the rat CYP2A3 gene in transgenic mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 548-52. PMID 11950786 DOI: 10.1124/Dmd.30.5.548  0.382
2001 Liu N, Zhang QY, Vakharia D, Dunbar D, Kaminsky LS. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? Archives of Biochemistry and Biophysics. 389: 130-134. PMID 11370663 DOI: 10.1006/Abbi.2001.2323  0.361
1999 Gu J, Dudley C, Su T, Spink DC, Zhang QY, Moss RL, Ding X. Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa. Biochemical and Biophysical Research Communications. 266: 262-7. PMID 10581200 DOI: 10.1006/Bbrc.1999.1807  0.357
1997 Hua Z, Zhang QY, Su T, Lipinskas TW, Ding X. cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase. Archives of Biochemistry and Biophysics. 340: 208-14. PMID 9143323 DOI: 10.1006/Abbi.1997.9899  0.332
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