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Klaus P. Hoeflich, Ph.D. - Publications

Affiliations: 
2001 University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Dogan T, Gnad F, Chan J, Phu L, Young A, Chen MJ, Doll S, Stokes MP, Belvin M, Friedman LS, Kirkpatrick DS, Hoeflich KP, Hatzivassiliou G. Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling to the cell cycle. The Journal of Biological Chemistry. PMID 28655764 DOI: 10.1074/Jbc.M117.792754  0.354
2013 Kirkpatrick DS, Bustos DJ, Dogan T, Chan J, Phu L, Young A, Friedman LS, Belvin M, Song Q, Bakalarski CE, Hoeflich KP. Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition. Proceedings of the National Academy of Sciences of the United States of America. 110: 19426-31. PMID 24218548 DOI: 10.1073/Pnas.1309473110  0.342
2011 Ong CC, Jubb AM, Zhou W, Haverty PM, Harris AL, Belvin M, Friedman LS, Koeppen H, Hoeflich KP. p21-activated kinase 1: PAK'ed with potential. Oncotarget. 2: 491-6. PMID 21653999 DOI: 10.18632/Oncotarget.271  0.3
2011 Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP. Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 7177-82. PMID 21482786 DOI: 10.1073/Pnas.1103350108  0.329
2010 Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 464: 431-5. PMID 20130576 DOI: 10.1038/nature08833  0.334
2010 Hoeflich K, Ong C, Jubb A, Haverty P, Truong T, Harris A, Belvin M, Friedman L, Blackwood E, Koeppen H. 343 Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells European Journal of Cancer Supplements. 8: 109. DOI: 10.1016/S1359-6349(10)72050-4  0.32
2009 Hoeflich KP, Herter S, Tien J, Wong L, Berry L, Chan J, O'Brien C, Modrusan Z, Seshagiri S, Lackner M, Stern H, Choo E, Murray L, Friedman LS, Belvin M. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Research. 69: 3042-51. PMID 19276360 DOI: 10.1158/0008-5472.CAN-08-3563  0.358
2008 Degtyarev M, De Mazière A, Orr C, Lin J, Lee BB, Tien JY, Prior WW, van Dijk S, Wu H, Gray DC, Davis DP, Stern HM, Murray LJ, Hoeflich KP, Klumperman J, et al. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. The Journal of Cell Biology. 183: 101-16. PMID 18838554 DOI: 10.1083/Jcb.200801099  0.312
2006 Hoeflich KP, Eby MT, Forrest WF, Gray DC, Tien JY, Stern HM, Murray LJ, Davis DP, Modrusan Z, Seshagiri S. Regulation of ERK3/MAPK6 expression by BRAF. International Journal of Oncology. 29: 839-49. PMID 16964379 DOI: 10.3892/Ijo.29.4.839  0.359
2004 Hoeflich KP, Ikura M. Radixin: cytoskeletal adopter and signaling protein. The International Journal of Biochemistry & Cell Biology. 36: 2131-6. PMID 15313460 DOI: 10.1016/J.Biocel.2003.11.018  0.338
2003 Zhang Y, Zhang J, Hoeflich KP, Ikura M, Qing G, Inouye M. MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Molecular Cell. 12: 913-23. PMID 14580342 DOI: 10.1016/S1097-2765(03)00402-7  0.308
2003 Hoeflich KP, Tsukita S, Hicks L, Kay CM, Tsukita S, Ikura M. Insights into a single rod-like helix in activated radixin required for membrane-cytoskeletal cross-linking. Biochemistry. 42: 11634-41. PMID 14529273 DOI: 10.1021/Bi0350497  0.331
2001 Ali A, Hoeflich KP, Woodgett JR. Glycogen synthase kinase-3: properties, functions, and regulation. Chemical Reviews. 101: 2527-40. PMID 11749387 DOI: 10.1021/Cr000110O  0.45
2001 Hoeflich KP, Woodgett JR. Chapter 13 Mitogen-activated protein kinases and stress Cell and Molecular Response to Stress. 2: 175-193. DOI: 10.1016/S1568-1254(01)80015-2  0.463
2000 Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature. 406: 86-90. PMID 10894547 DOI: 10.1038/35017574  0.48
1999 Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. 18: 5814-20. PMID 10523862 DOI: 10.1038/Sj.Onc.1202975  0.551
1999 Cannons JL, Hoeflich KP, Woodgett JR, Watts TH. Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB. Journal of Immunology (Baltimore, Md. : 1950). 163: 2990-8. PMID 10477561  0.463
1999 Lee ST, Hoeflich KP, Wasfy GW, Woodgett JR, Leber B, Andrews DW, Hedley DW, Penn LZ. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts. Oncogene. 18: 3520-8. PMID 10376530 DOI: 10.1038/Sj.Onc.1202716  0.454
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