Thurl E. Harris, Ph.D. - Publications

Affiliations: 
Pharmacology University of Virginia, Charlottesville, VA 

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ware TB, Franks CE, Granade ME, Zhang M, Kim KB, Park KS, Gahlmann A, Harris TE, Hsu KL. Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering. Nature Chemical Biology. PMID 31932721 DOI: 10.1038/S41589-019-0445-9  0.352
2019 Krüger N, Biwer LA, Good ME, Ruddiman CA, Wolpe AG, DeLalio LJ, Murphy S, Macal EH, Ragolia L, Serbulea V, Best AK, Leitinger N, Harris TE, Sonkusare SK, Gödecke A, et al. Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. Circulation Research. PMID 31801409 DOI: 10.1161/Circresaha.119.315531  0.314
2019 Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM. Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein. The Journal of Biological Chemistry. PMID 30617183 DOI: 10.1074/Jbc.Ra118.007246  0.371
2018 Granade ME, Harris TE. Purification of Lipin and Measurement of Phosphatidic Acid Phosphatase Activity from Liposomes. Methods in Enzymology. 607: 373-388. PMID 30149866 DOI: 10.1016/Bs.Mie.2018.04.028  0.331
2018 Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN. Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800361R. PMID 30028636 DOI: 10.1096/Fj.201800361R  0.346
2018 Cantwell MT, Farrar JS, Lownik JC, Meier JA, Hyun M, Raje V, Waters MR, Celi FS, Conrad DH, Harris TE, Larner AC. STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis. Cytokine. PMID 29934048 DOI: 10.1016/J.Cyto.2018.05.023  0.33
2018 Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK. Klf4 has an unexpected protective role in perivascular cells within the microvasculature. American Journal of Physiology. Heart and Circulatory Physiology. PMID 29631369 DOI: 10.1152/Ajpheart.00084.2018  0.331
2018 Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z. Modulation of GSK3β autoinhibition by Thr-7 and Thr-8. Febs Letters. PMID 29377106 DOI: 10.1002/1873-3468.12990  0.439
2018 Meher AK, Serbulea V, Upchurch CM, Osinski V, Sahu S, Hargett S, Hoehn KL, Harris TE, Klibanov AL, McNamara CA, Leitinger N. Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.428  0.32
2018 Ahern K, Mullins G, Raje V, Granade M, Harris T. Oxidized neutral lipid lipolysis regulates insulin signaling during acute stress Free Radical Biology and Medicine. 128. DOI: 10.1016/J.Freeradbiomed.2018.10.174  0.409
2017 McCloud RL, Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL. Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics. Biochemistry. PMID 29155586 DOI: 10.1021/Acs.Biochem.7B00962  0.402
2017 Boroda S, Takkellapati S, Lawrence RT, Entwisle SW, Pearson JM, Granade ME, Mullins GR, Eaton JM, Villén J, Harris TE. The Phosphatidic Acid-Binding, Polybasic Domain is Responsible for the Differences in the Phosphoregulation of Lipins 1 and 3. The Journal of Biological Chemistry. PMID 28982975 DOI: 10.1074/Jbc.M117.786574  0.389
2017 Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF, Wotton D, Paschal BM. The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. The Prostate. PMID 28875501 DOI: 10.1002/Pros.23400  0.347
2017 Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL. The Ligand Binding Landscape of Diacylglycerol Kinases. Cell Chemical Biology. PMID 28712745 DOI: 10.1016/J.Chembiol.2017.06.007  0.383
2017 He J, Zhang F, Tay LW, Boroda S, Nian W, Levental KR, Levental I, Harris TE, Chang JT, Du G. Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28347999 DOI: 10.1096/Fj.201601353R  0.321
2017 Taddeo EP, Hargett SR, Lahiri S, Nelson ME, Liao JA, Li C, Slack-Davis JK, Tomsig JL, Lynch KR, Yan Z, Harris TE, Hoehn KL. Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3. Scientific Reports. 7: 127. PMID 28273928 DOI: 10.1038/S41598-017-00210-Y  0.377
2017 Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM. Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight. The Journal of Clinical Investigation. PMID 28218622 DOI: 10.1172/Jci81335  0.3
2016 Boroda S, Niccum M, Raje V, Purow BW, Harris TE. Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists. Biochemical Pharmacology. PMID 27974147 DOI: 10.1016/J.Bcp.2016.10.011  0.315
2016 Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, ... Harris TE, et al. SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports. 17: 1546-1559. PMID 27806294 DOI: 10.1016/J.Celrep.2016.10.037  0.391
2016 Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler JD, Strobl B, Gamero A, Harris TE, Larner AC. Kinase inactive Tyrosine kinase (Tyk2) Supports Differentiation of Brown fat Cells. Endocrinology. en20152048. PMID 27802075 DOI: 10.1210/En.2015-2048  0.411
2016 Adamson SE, Griffiths R, Moravec R, Senthivinayagam S, Montgomery G, Chen W, Han J, Sharma PR, Mullins GR, Gorski SA, Cooper JA, Kadl A, Enfield K, Braciale TJ, Harris TE, et al. Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation. The Journal of Clinical Investigation. PMID 26927671 DOI: 10.1172/Jci79590  0.338
2015 Sisler JD, Morgan M, Raje V, Grande RC, Derecka M, Meier J, Cantwell M, Szczepanek K, Korzun WJ, Lesnefsky EJ, Harris TE, Croniger CM, Larner AC. The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes. Plos One. 10: e0144444. PMID 26689548 DOI: 10.1371/Journal.Pone.0144444  0.389
2015 Adamson SE, Meher AK, Chiu YH, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, Peirce-Cottler SM, Isakson BE, McNamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N. Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. Molecular Metabolism. 4: 610-8. PMID 26413467 DOI: 10.1016/J.Molmet.2015.06.009  0.37
2015 Chao H, Li H, Grande R, Lira V, Yan Z, Harris TE, Li C. Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells. Molecular Endocrinology (Baltimore, Md.). 29: 831-41. PMID 25875045 DOI: 10.1210/Me.2014-1245  0.393
2015 Zhang C, Hwarng G, Cooper DE, Grevengoed TJ, Eaton JM, Natarajan V, Harris TE, Coleman RA. Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol. The Journal of Biological Chemistry. 290: 3519-28. PMID 25512376 DOI: 10.1074/Jbc.M114.602789  0.43
2014 Mullins GR, Wang L, Raje V, Sherwood SG, Grande RC, Boroda S, Eaton JM, Blancquaert S, Roger PP, Leitinger N, Harris TE. Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes. Proceedings of the National Academy of Sciences of the United States of America. 111: 17450-5. PMID 25422441 DOI: 10.1073/Pnas.1410530111  0.386
2014 Zhang C, Cooper DE, Grevengoed TJ, Li LO, Klett EL, Eaton JM, Harris TE, Coleman RA. Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor. American Journal of Physiology. Endocrinology and Metabolism. 307: E305-15. PMID 24939733 DOI: 10.1152/Ajpendo.00034.2014  0.413
2014 Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE. Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation. The Journal of Biological Chemistry. 289: 18055-66. PMID 24811178 DOI: 10.1074/Jbc.M114.547604  0.438
2014 Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular Metabolism. 3: 124-34. PMID 24634818 DOI: 10.1016/J.Molmet.2013.11.003  0.354
2014 Kok BP, Skene-Arnold TD, Ling J, Benesch MG, Dewald J, Harris TE, Holmes CF, Brindley DN. Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity. The Journal of Biological Chemistry. 289: 10876-86. PMID 24558042 DOI: 10.1074/Jbc.M114.552612  0.339
2014 Floyd D, Comeau L, Boroda S, Hayes N, Roller D, Xiao A, Friedman A, Boyd L, Gioeli D, Harris T, Harris T, Purow B. PM-02 * DIACYLGLYCEROL KINASE ALPHA INHIBITION PROLONGS SURVIVAL OF MICE WITH PRIMARY AND METASTATIC BRAIN TUMORS Neuro-Oncology. 16: v169-v169. DOI: 10.1093/Neuonc/Nou268.2  0.31
2013 Dominguez CL, Floyd DH, Xiao A, Mullins GR, Kefas BA, Xin W, Yacur MN, Abounader R, Lee JK, Wilson GM, Harris TE, Purow BW. Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers. Cancer Discovery. 3: 782-97. PMID 23558954 DOI: 10.1158/2159-8290.Cd-12-0215  0.336
2013 Kok BP, Dyck JR, Harris TE, Brindley DN. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver. Journal of Lipid Research. 54: 1662-77. PMID 23505321 DOI: 10.1194/Jlr.M036624  0.304
2013 Eaton JM, Mullins GR, Brindley DN, Harris TE. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association. The Journal of Biological Chemistry. 288: 9933-45. PMID 23426360 DOI: 10.1074/Jbc.M112.441493  0.37
2013 Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN. Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Proceedings of the National Academy of Sciences of the United States of America. 110: 642-7. PMID 23267081 DOI: 10.1073/Pnas.1213493110  0.463
2012 Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, ... Harris TE, et al. Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metabolism. 16: 814-24. PMID 23217260 DOI: 10.1016/J.Cmet.2012.11.005  0.374
2012 Wu D, Chapman JR, Wang L, Harris TE, Shabanowitz J, Hunt DF, Fu Z. Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908. The Journal of Biological Chemistry. 287: 12510-9. PMID 22356909 DOI: 10.1074/Jbc.M111.302117  0.446
2012 Zhang C, Wendel AA, Keogh MR, Harris TE, Chen J, Coleman RA. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: 1667-72. PMID 22307628 DOI: 10.1073/Pnas.1110730109  0.458
2012 Glidden EJ, Gray LG, Vemuru S, Li D, Harris TE, Mayo MW. Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein. The Journal of Biological Chemistry. 287: 581-8. PMID 22084251 DOI: 10.1074/Jbc.M111.304337  0.442
2012 González IM, Martin PM, Burdsal C, Sloan JL, Mager S, Harris T, Sutherland AE. Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo. Developmental Biology. 361: 286-300. PMID 22056783 DOI: 10.1016/J.Ydbio.2011.10.021  0.344
2011 Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146: 408-20. PMID 21816276 DOI: 10.1016/J.Cell.2011.06.034  0.416
2011 Harris TE, Finck BN. Dual function lipin proteins and glycerolipid metabolism. Trends in Endocrinology and Metabolism: Tem. 22: 226-33. PMID 21470873 DOI: 10.1016/J.Tem.2011.02.006  0.34
2011 Kumar A, Keller SR, Kim JK, Magnuson MA, Harris TE. Response to Comment on: Kumar et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 2010;59:1397-1406 Diabetes. 60: e15. DOI: 10.2337/Db11-0135  0.375
2010 Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE. Lipin proteins form homo- and hetero-oligomers. The Biochemical Journal. 432: 65-76. PMID 20735359 DOI: 10.1042/Bj20100584  0.315
2010 Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP. cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Molecular Endocrinology (Baltimore, Md.). 24: 1453-68. PMID 20484410 DOI: 10.1210/Me.2010-0087  0.445
2010 Kim HB, Kumar A, Wang L, Liu GH, Keller SR, Lawrence JC, Finck BN, Harris TE. Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Molecular and Cellular Biology. 30: 3126-39. PMID 20385772 DOI: 10.1128/Mcb.01671-09  0.397
2010 Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes. 59: 1397-406. PMID 20332342 DOI: 10.2337/Db09-1061  0.453
2010 Péterfy M, Harris TE, Fujita N, Reue K. Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. The Journal of Biological Chemistry. 285: 3857-64. PMID 19955570 DOI: 10.1074/Jbc.M109.072488  0.406
2009 Wang L, Lawrence JC, Sturgill TW, Harris TE. Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. The Journal of Biological Chemistry. 284: 14693-7. PMID 19346248 DOI: 10.1074/Jbc.C109.002907  0.466
2009 Zhang F, Beharry ZM, Harris TE, Lilly MB, Smith CD, Mahajan S, Kraft AS. PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells. Cancer Biology & Therapy. 8: 846-53. PMID 19276681 DOI: 10.4161/Cbt.8.9.8210  0.418
2009 Gropler MC, Harris TE, Hall AM, Wolins NE, Gross RW, Han X, Chen Z, Finck BN. Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. The Journal of Biological Chemistry. 284: 6763-72. PMID 19136718 DOI: 10.1074/Jbc.M807882200  0.356
2008 Chen Z, Gropler MC, Norris J, Lawrence JC, Harris TE, Finck BN. Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1738-44. PMID 18669885 DOI: 10.1161/Atvbaha.108.171538  0.405
2008 Wang L, Harris TE, Lawrence JC. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. The Journal of Biological Chemistry. 283: 15619-27. PMID 18372248 DOI: 10.1074/Jbc.M800723200  0.4
2008 Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Molecular and Cellular Biology. 28: 61-70. PMID 17967879 DOI: 10.1128/Mcb.01405-07  0.438
2007 Wang L, Harris TE, Roth RA, Lawrence JC. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. The Journal of Biological Chemistry. 282: 20036-44. PMID 17510057 DOI: 10.1074/Jbc.M702376200  0.449
2007 Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC, Dixon JE. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 6596-601. PMID 17420445 DOI: 10.1073/Pnas.0702099104  0.334
2007 Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence JC. Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. The Journal of Biological Chemistry. 282: 277-86. PMID 17105729 DOI: 10.1074/Jbc.M609537200  0.457
2006 Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, Kelly DP. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metabolism. 4: 199-210. PMID 16950137 DOI: 10.1016/J.Cmet.2006.08.005  0.327
2006 Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC. mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin. The Embo Journal. 25: 1659-68. PMID 16541103 DOI: 10.1038/Sj.Emboj.7601047  0.415
2005 Reynolds TH, Pak Y, Harris TE, Manchester J, Barrett EJ, Lawrence JC. Effects of insulin and transgenic overexpression of UDP-glucose pyrophosphorylase on UDP-glucose and glycogen accumulation in skeletal muscle fibers. The Journal of Biological Chemistry. 280: 5510-5. PMID 15596435 DOI: 10.1074/Jbc.M413614200  0.323
1999 Persaud SJ, Harris TE, Burns CJ, Jones PM. Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets. Journal of Molecular Endocrinology. 22: 19-28. PMID 9924176 DOI: 10.1677/jme.0.0220019  0.318
1999 Jones PM, Persaud SJ, Harris TE. Signal Transduction. Protein Phosphorylation and the Regulation of Insulin Secretion Advances in Molecular and Cell Biology. 29: 303-334. DOI: 10.1016/S1569-2558(08)60098-3  0.306
1997 Harris TE, Persaud SJ, Jones PM. Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: effects on cyclic AMP-dependent and glucose-dependent insulin secretion. Biochemical and Biophysical Research Communications. 232: 648-51. PMID 9126329 DOI: 10.1006/bbrc.1997.6344  0.304
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