Thomas L. Ciardelli - Publications

Dartmouth College, Hanover, NH, United States 
Biochemistry, Pharmacology, General Biophysics

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2003 Rao BM, Girvin AT, Ciardelli T, Lauffenburger DA, Wittrup KD. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Engineering. 16: 1081-7. PMID 14983090 DOI: 10.1093/protein/gzg111  0.6
2002 Liparoto SF, Myszka DG, Wu Z, Goldstein B, Laue TM, Ciardelli TL. Analysis of the role of the interleukin-2 receptor gamma chain in ligand binding. Biochemistry. 41: 2543-51. PMID 11851401 DOI: 10.1021/bi011692m  0.6
2000 Fallon EM, Liparoto SF, Lee KJ, Ciardelli TL, Lauffenburger DA. Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog. The Journal of Biological Chemistry. 275: 6790-7. PMID 10702236 DOI: 10.1074/jbc.275.10.6790  0.6
1999 Liparoto SF, Ciardelli TL. Biosensor analysis of the interleukin-2 receptor complex. Journal of Molecular Recognition : Jmr. 12: 316-21. PMID 10556880 DOI: 10.1002/(SICI)1099-1352(199909/10)12:5<316::AID-JMR468>3.0.CO;2-1  0.6
1999 Wu Z, Goldstein B, Laue TM, Liparoto SF, Nemeth MJ, Ciardelli TL. Solution assembly of the pseudo-high affinity and intermediate affinity interleukin-2 receptor complexes. Protein Science : a Publication of the Protein Society. 8: 482-9. PMID 10091650 DOI: 10.1110/ps.8.3.482  0.6
1997 Wang R, Ciardelli TL, Russell JH. Partial signaling by cytokines: cytokine regulation of cell cycle and Fas-dependent, activation-induced death in CD4+ subsets. Cellular Immunology. 182: 152-60. PMID 9514696 DOI: 10.1006/cimm.1997.1220  0.6
1997 Ruben GC, Ciardelli TL, Grundke-Iqbal I, Iqbal K. Alzheimer disease hyperphosphorylated tau aggregates hydrophobically. Synapse (New York, N.Y.). 27: 208-29. PMID 9329157 DOI: 10.1002/(SICI)1098-2396(199711)27:3<208::AID-SYN7>3.0.CO;2-H  0.6
1997 Lee BL, Ciardelli TL. Structural modifications of interleukin-2 at positions 47 and 65. Biochemical and Biophysical Research Communications. 233: 309-15. PMID 9144530 DOI: 10.1006/bbrc.1997.6453  0.6
1997 Buchli PJ, Wu Z, Ciardelli TL. The functional display of interleukin-2 on filamentous phage. Archives of Biochemistry and Biophysics. 339: 79-84. PMID 9056236 DOI: 10.1006/abbi.1996.9853  0.6
1996 Ciardelli TL. Reengineering growth factors "through the looking glass". Nature Biotechnology. 14: 1652. PMID 9634842 DOI: 10.1038/nbt1296-1652  0.6
1996 Myszka DG, Arulanantham PR, Sana T, Wu Z, Morton TA, Ciardelli TL. Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surface. Protein Science : a Publication of the Protein Society. 5: 2468-78. PMID 8976555 DOI: 10.1002/pro.5560051209  0.6
1996 Cardi G, Ciardelli TL, Ernstoff MS. Therapeutic applications of cytokines for immunostimulation and immunosuppression: an update. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 47: 211-50. PMID 8961768  0.6
1996 Chang DZ, Wu Z, Ciardelli TL. A point mutation in interleukin-2 that alters ligand internalization. The Journal of Biological Chemistry. 271: 13349-55. PMID 8662876 DOI: 10.1074/jbc.271.23.13349  0.6
1996 vanderSpek JC, Sutherland JA, Ratnarathorn M, Howland K, Ciardelli TL, Murphy JR. DAB389 interleukin-2 receptor binding domain mutations. Cytotoxic probes for studies of ligand-receptor interactions. The Journal of Biological Chemistry. 271: 12145-9. PMID 8647806 DOI: 10.1074/jbc.271.21.12145  0.6
1996 Wu Z, Johnson KW, Goldstein B, Laue TM, Ciardelli TL. Solution assembly of cytokine receptor ectodomain complexes Techniques in Protein Chemistry. 7: 45-56. DOI: 10.1016/S1080-8914(96)80008-1  0.6
1995 Chang DZ, Tasayco ML, Ciardelli TL. Structural analogs of interleukin-2: a point mutation that facilitates biological response. Molecular Pharmacology. 47: 206-11. PMID 7838130  0.6
1995 Wu Z, Johnson KW, Choi Y, Ciardelli TL. Ligand binding analysis of soluble interleukin-2 receptor complexes by surface plasmon resonance. The Journal of Biological Chemistry. 270: 16045-51. PMID 7608166 DOI: 10.1074/jbc.270.27.16045  0.6
1995 Wu Z, Johnson KW, Goldstein B, Choi Y, Eaton SF, Laue TM, Ciardelli TL. Solution assembly of a soluble, heteromeric, high affinity interleukin-2 receptor complex. The Journal of Biological Chemistry. 270: 16039-44. PMID 7608165 DOI: 10.1074/jbc.270.27.16039  0.6
1995 Wu Z, Johnson KW, Ciardelli TL. Ligand binding analysis of interleukin-2 receptor complexes using surface plasmon resonance. Journal of Immunological Methods. 183: 127-30. PMID 7602130  0.6
1994 Berndt WG, Chang DZ, Smith KA, Ciardelli TL. Mutagenic analysis of a receptor contact site on interleukin-2: preparation of an IL-2 analog with increased potency. Biochemistry. 33: 6571-7. PMID 8204593 DOI: 10.1021/bi00187a026  0.6
1994 Nakarai T, Robertson MJ, Streuli M, Wu Z, Ciardelli TL, Smith KA, Ritz J. Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells. The Journal of Experimental Medicine. 180: 241-51. PMID 8006584 DOI: 10.1084/jem.180.1.241  0.6
1994 Wu Z, Eaton SF, Laue TM, Johnson KW, Sana TR, Ciardelli TL. Coiled-coil molecular recognition: directed solution assembly of receptor ectodomains. Protein Engineering. 7: 1137-44. PMID 7831285 DOI: 10.1093/protein/7.9.1137  0.6
1994 Johnson K, Granzow R, Creasey A, Ciardelli T. Ligand Binding Analyses and Functional Activity of Interleukin-2 Receptor Ectodomains Methods. 6: 199-205. DOI: 10.1006/meth.1994.1022  0.6
1993 Lee BL, Ciardelli TL. Conformation studies of interleukin-2 mutants: Generation of partial agonists Protein Engineering, Design and Selection. 6: 115. DOI: 10.1093/protein/6.Supplement.115-b  0.6
1992 Landgraf BE, Goldstein B, Williams DP, Murphy JR, Sana TR, Smith KA, Ciardelli TL. Recombinant interleukin-2 analogs. Dynamic probes for receptor structure. The Journal of Biological Chemistry. 267: 18511-9. PMID 1526987  0.6
1992 Lee B, Ciardelli TL. Clinical applications of cytokines for immunostimulation and immunosuppression. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 39: 167-96. PMID 1475362  0.6
1991 Ackland CE, Berndt WG, Frezza JE, Landgraf BE, Pritchard KW, Ciardelli TL. Monitoring of protein conformation by high-performance size-exclusion liquid chromatography and scanning diode array second-derivative UV absorption spectroscopy. Journal of Chromatography. 540: 187-98. PMID 2071687 DOI: 10.1016/S0021-9673(01)88808-7  0.6
1991 Landgraf BE, Williams DP, Murphy JR, Smith KA, Ciardelli TL. Conformational perturbation of interleukin-2: a strategy for the design of cytokine analogs. Proteins. 9: 207-16. PMID 2006138 DOI: 10.1002/prot.340090306  0.6
1991 Ruben GC, Iqbal K, Grundke-Iqbal I, Wisniewski HM, Ciardelli TL, Johnson JE. The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer. The Journal of Biological Chemistry. 266: 22019-27. PMID 1939223  0.6
1991 Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA. Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone. The Journal of Biological Chemistry. 266: 1997-2004. PMID 1846369  0.6
1991 Gonsalves SF, Landgraf BE, Ciardelli TL, Borison HL. Early toxicity of recombinant interleukin-2 in cats. Archives Internationales De Pharmacodynamie Et De théRapie. 310: 175-85. PMID 1772328  0.6
1990 Recny MA, Neidhardt EA, Sayre PH, Ciardelli TL, Reinherz EL. Structural and functional characterization of the CD2 immunoadhesion domain. Evidence for inclusion of CD2 in an alpha-beta protein folding class. The Journal of Biological Chemistry. 265: 8542-9. PMID 1971273  0.6
1990 Davies A, Ciardelli TL, Lienhard GE, Boyle JM, Whetton AD, Baldwin SA. Site-specific antibodies as probes of the topology and function of the human erythrocyte glucose transporter. The Biochemical Journal. 266: 799-808. PMID 1691633  0.6
1990 Jon Kull F, Reed MF, Elgren TE, Ciardelli TL, Wilcox DE. Solid-phase peptide synthesis of the α and ab domains of human liver metallothionein 2 and the metallothionein of Neurospora crassa Journal of the American Chemical Society. 112: 2291-2298.  0.6
1989 Landgraf B, Cohen FE, Smith KA, Gadski R, Ciardelli TL. Structural significance of the C-terminal amphiphilic helix of interleukin-2. The Journal of Biological Chemistry. 264: 816-22. PMID 2783421  0.6
1989 Sayre PH, Hussey RE, Chang HC, Ciardelli TL, Reinherz EL. Structural and binding analysis of a two domain extracellular CD2 molecule. The Journal of Experimental Medicine. 169: 995-1009. PMID 2466941  0.6
1988 Smith LI, Bodwell JE, Mendel DB, Ciardelli T, North WG, Munck A. Identification of cysteine-644 as the covalent site of attachment of dexamethasone 21-mesylate to murine glucocorticoid receptors in WEHI-7 cells. Biochemistry. 27: 3747-53. PMID 3408724 DOI: 10.1021/bi00410a034  0.6
1988 Ciardelli TL, Landgraf B, Gadski R, Strnad J, Cohen FE, Smith KA. A design approach to the structural analysis of interleukin-2. Journal of Molecular Recognition : Jmr. 1: 42-7. PMID 3273651 DOI: 10.1002/jmr.300010108  0.6
1986 Cohen FE, Kosen PA, Kuntz ID, Epstein LB, Ciardelli TL, Smith KA. Structure-activity studies of interleukin-2 Science. 234: 349-352. PMID 3489989 DOI: 10.1126/science.3489989  0.6
1982 Ciardelli TL, Incefy GS, Birr C. Activity of synthetic thymosin alpha 1 C-terminal peptides in the azathioprine E-rosette inhibition assay. Biochemistry. 21: 4233-7. PMID 6982069  0.6
1981 Thorpe C, Ciardelli TL, Stewart CJ, Wieland T. Interaction of long-chain acyl-CoA analogs with pig kidney general acyl-CoA dehydrogenase. European Journal of Biochemistry / Febs. 118: 279-82. PMID 7285923 DOI: 10.1111/j.1432-1033.1981.tb06397.x  0.6
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