David M. Virshup - Publications

University of Utah, Salt Lake City, UT 
Biochemistry, Molecular Physics, Molecular Biology

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kaur A, Lim JYS, Sepramaniam S, Patnaik S, Harmston N, Lee MA, Petretto E, Virshup DM, Madan B. WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. Embo Molecular Medicine. e13349. PMID 33660437 DOI: 10.15252/emmm.202013349  0.36
2021 Zacarías-Fluck MF, Jauset T, Martínez-Martín S, Kaur J, Casacuberta-Serra S, Massó-Vallés D, Serrano Del Pozo E, Martín-Fernández G, González-Larreategui Í, López-Estévez S, Brown-Swigart L, Beaulieu ME, Whitfield JR, Madan B, Virshup DM, et al. The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. Life Science Alliance. 4. PMID 33653688 DOI: 10.26508/lsa.201900490  0.36
2020 Nygaard R, Yu J, Kim J, Ross DR, Parisi G, Clarke OB, Virshup DM, Mancia F. Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. Cell. PMID 33357447 DOI: 10.1016/j.cell.2020.11.038  0.36
2020 Harmston N, Lim JYS, Arqués O, Palmer HG, Petretto E, Virshup DM, Madan B. Widespread repression of gene expression in cancer by a Wnt/β-catenin/MAPK pathway. Cancer Research. PMID 33203702 DOI: 10.1158/0008-5472.CAN-20-2129  0.36
2020 Liu S, Harmston N, Glaser TL, Wong Y, Zhong Z, Madan B, Virshup DM, Petretto E. Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. Genome Medicine. 12: 89. PMID 33092630 DOI: 10.1186/s13073-020-00788-5  0.48
2020 Yu J, Mohamed Yuso PAB, Woutersen DTJ, Goh P, Harmston N, Smits R, Epstein D, Virshup DM, Madan B. The functional landscape of patient-derived RNF43 mutations predicts sensitivity to Wnt inhibiton. Cancer Research. PMID 33067269 DOI: 10.1158/0008-5472.CAN-20-0957  0.36
2020 Zhong Z, Yu J, Virshup DM, Madan B. Wnts and the hallmarks of cancer. Cancer Metastasis Reviews. PMID 32385713 DOI: 10.1007/s10555-020-09887-6  0.48
2019 Zhong Z, Virshup DM. Wnt signaling and drug resistance in cancer. Molecular Pharmacology. PMID 31787618 DOI: 10.1124/mol.119.117978  0.36
2019 Lu X, Rudemiller NP, Ren J, Wen Y, Yang B, Griffiths R, Privratsky JR, Madan B, Virshup DM, Crowley SD. Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis. Kidney International. PMID 31585741 DOI: 10.1016/j.kint.2019.06.020  0.36
2019 Idris M, Harmston N, Petretto EG, Madan B, Virshup DM. Broad regulation of gene isoform expression by Wnt signaling in cancer. Rna (New York, N.Y.). PMID 31506381 DOI: 10.1261/rna.071506.119  0.36
2019 Zhong Z, Sepramaniam S, Chew XH, Wood K, Lee MA, Madan B, Virshup DM. PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. Oncogene. PMID 31391551 DOI: 10.1038/s41388-019-0908-1  0.48
2019 Moti N, Yu J, Boncompain G, Perez F, Virshup DM. Wnt traffic from endoplasmic reticulum to filopodia. Plos One. 14: e0212711. PMID 30794657 DOI: 10.1371/journal.pone.0212711  0.36
2018 Tan D, Ng M, Subbiah V, Messersmith W, Teneggi V, Diermayr V, Ethirajulu K, Yeo P, Gan BH, Lee LH, Blanchard S, Nellore R, Yasin M, Umrani D, Lee MA, ... ... Virshup D, et al. Phase I extension study of ETC-159 an oral PORCN inhibitor administered with bone protective treatment, in patients with advanced solid tumours. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 29: ix23-ix24. PMID 32177962 DOI: 10.1093/annonc/mdy430.002  0.36
2018 Madan B, Harmston N, Nallan G, Montoya A, Faull P, Petretto E, Virshup DM. Temporal dynamics of Wnt-dependent transcriptome reveals an oncogenic Wnt/MYC/ribosome axis. The Journal of Clinical Investigation. PMID 30300142 DOI: 10.1172/JCI122383  0.36
2018 Chee YC, Pahnke J, Bunte R, Adsool VA, Madan B, Virshup DM. Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. Developmental Cell. PMID 30146480 DOI: 10.1016/j.devcel.2018.07.023  0.48
2018 Kabiri Z, Greicius G, Zaribafzadeh H, Hemmerich A, Counter CM, Virshup DM. Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. The Journal of Clinical Investigation. PMID 30059017 DOI: 10.1172/JCI99325  0.48
2018 Madan B, McDonald MJ, Foxa GE, Diegel CR, Williams BO, Virshup DM. Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy. Bone Research. 6: 17. PMID 29844946 DOI: 10.1038/s41413-018-0017-8  0.48
2018 Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM. CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. Proceedings of the National Academy of Sciences of the United States of America. PMID 29784789 DOI: 10.1073/pnas.1721076115  0.64
2018 Greicius G, Kabiri Z, Sigmundsson K, Liang C, Bunte R, Singh MK, Virshup DM. pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 29559533 DOI: 10.1073/pnas.1713510115  0.48
2017 Zhang F, Virshup DM, Cheong JK. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. PMID 28945225 DOI: 10.1038/onc.2017.334  0.32
2017 Ho SY, Alam J, Jeyaraj DA, Wang W, Lin GR, Ang SH, Tan ESW, Lee MA, Ke Z, Madan B, Virshup DM, Ding LJ, Manoharan V, Chew YS, Low CB, et al. Scaffold hopping and Optimization of Maleimide based Porcupine Inhibitors. Journal of Medicinal Chemistry. PMID 28671458 DOI: 10.1021/acs.jmedchem.7b00662  0.36
2017 Alok A, Lei Z, Jagannathan NS, Kaur S, Rozen SG, Tucker-Kellogg L, Virshup DM. Wnts synergize to activate β-catenin signaling. Journal of Cell Science. PMID 28289266 DOI: 10.1242/jcs.198093  0.32
2016 Cheong JK, Virshup DM. CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers? Annals of Translational Medicine. 4: 433. PMID 27942524 DOI: 10.21037/atm.2016.11.07  0.32
2016 Wang J, Wang Z, Yu T, Yang H, Virshup DM, Kops GJ, Lee SH, Zhou W, Li X, Xu W, Rao Z. Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization. Protein & Cell. PMID 27350047 DOI: 10.1007/s13238-016-0283-4  1
2016 Cheong JK, Virshup DM. Keeping autophagy in cheCK1. Molecular & Cellular Oncology. 3: e1045117. PMID 27314070 DOI: 10.1080/23723556.2015.1045117  0.32
2016 Liu CC, Ma DL, Yan TD, Fan X, Poon Z, Poon LF, Goh SA, Rozen SG, Ying Khee Hwang W, Tergaonkar V, Tan P, Ghosh S, Virshup DM, Goh EL, Li S. Distinct Responses of stem Cells to Telomere Uncapping - a Potential Strategy to Improve the Safety Of Cell Therapy. Stem Cells (Dayton, Ohio). PMID 27299710 DOI: 10.1002/stem.2431  1
2016 Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, ... Virshup DM, et al. USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162353 DOI: 10.1073/pnas.1605691113  1
2016 Madan B, Patel MB, Zhang J, Bunte RM, Rudemiller NP, Griffiths R, Virshup DM, Crowley SD. Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. Kidney International. 89: 1062-74. PMID 27083283 DOI: 10.1016/j.kint.2016.01.017  1
2016 Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, Rozen S, Virshup DM. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. Oncotarget. PMID 26848981 DOI: 10.18632/oncotarget.7157  1
2015 Zhou M, Kim JK, Eng GW, Forger DB, Virshup DM. A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. Molecular Cell. 60: 77-88. PMID 26431025 DOI: 10.1016/j.molcel.2015.08.022  1
2015 Xiang W, Cheong JK, Ang SH, Teo B, Xu P, Asari K, Sun WT, Than H, Bunte RM, Virshup DM, Chuah C. Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration. Oncotarget. PMID 26378050  0.36
2015 Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, ... Virshup DM, et al. Discovery and Optimization of a Porcupine Inhibitor. Journal of Medicinal Chemistry. PMID 26110200 DOI: 10.1021/acs.jmedchem.5b00507  1
2015 Kabiri Z, Numata A, Kawasaki A, Edison, Tenen DG, Virshup DM. Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. Blood. 126: 1086-94. PMID 26089398 DOI: 10.1182/blood-2014-09-598540  1
2015 Madan B, Virshup DM. Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs. Molecular Cancer Therapeutics. 14: 1087-94. PMID 25901018 DOI: 10.1158/1535-7163.MCT-14-1038  1
2015 Cheong JK, Zhang F, Chua PJ, Bay BH, Thorburn A, Virshup DM. Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. The Journal of Clinical Investigation. 125: 1401-18. PMID 25798617 DOI: 10.1172/JCI78018  1
2015 Ribi S, Baumhoer D, Lee K, Edison, Teo AS, Madan B, Zhang K, Kohlmann WK, Yao F, Lee WH, Hoi Q, Cai S, Woo XY, Tan P, Jundt G, ... ... Virshup DM, et al. TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome. Oncotarget. 6: 7727-40. PMID 25762628  0.48
2015 Virshup DM. Moving upstream in the war on WNTs. The Journal of Clinical Investigation. 125: 975-7. PMID 25689251 DOI: 10.1172/JCI80819  1
2015 Stewart J, James J, McCluggage GW, McQuaid S, Arthur K, Boyle D, Mullan P, McArt D, Yan B, Irwin G, Harkin DP, Zhengdeng L, Ong CW, Yu J, Virshup DM, et al. Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 28: 428-36. PMID 25258105 DOI: 10.1038/modpathol.2014.114  1
2015 Yim DG, Ghosh S, Guy GR, Virshup DM. Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene. 34: 474-84. PMID 24469046 DOI: 10.1038/onc.2013.564  1
2015 Xiang W, Cheong JK, Ang SH, Teo B, Xu P, Asari K, Sun WT, Than H, Bunte RM, Virshup DM, Chuah C. Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration Oncotarget. 6: 33769-33780. DOI: 10.18632/oncotarget.5615  1
2015 Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EHQ, Sangthongpitag K, Hill J, Petretto E, ... ... Virshup DM, et al. Wnt addiction of genetically defined cancers reversed by PORCN inhibition Oncogene. DOI: 10.1038/onc.2015.280  1
2015 Ribi S, Baumhoer D, Lee K, Edison, Teo ASM, Madan B, Zhang K, Kohlmann WK, Yao F, Lee WH, Hoi Q, Cai S, Woo XY, Tan P, Jundt G, ... ... Virshup DM, et al. TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome Oncotarget. 6: 7727-7740.  1
2014 Yu J, Virshup DM. Updating the Wnt pathways. Bioscience Reports. 34. PMID 25208913 DOI: 10.1042/BSR20140119  1
2014 Xu P, Virshup DM, Lee SH. B56-PP2A regulates motor dynamics for mitotic chromosome alignment. Journal of Cell Science. 127: 4567-73. PMID 25179604 DOI: 10.1242/jcs.154609  1
2014 Low ICC, Loh T, Huang Y, Virshup DM, Pervaiz S. Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 δ stabilizes its antiapoptotic activity Blood. 124: 2223-2234. PMID 25082878 DOI: 10.1182/blood-2014-03-563296  1
2014 Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. The Journal of Clinical Investigation. 124: 3263-73. PMID 24911145 DOI: 10.1172/JCI73015  1
2014 MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X. Disulfide bond requirements for active Wnt ligands. The Journal of Biological Chemistry. 289: 18122-36. PMID 24841207 DOI: 10.1074/jbc.M114.575027  1
2014 Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, Edison, Aliyev J, Wu Y, Bunte R, Williams BO, Rossant J, Virshup DM. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (Cambridge, England). 141: 2206-15. PMID 24821987 DOI: 10.1242/dev.104976  1
2014 Yu J, Chia J, Canning CA, Jones CM, Bard FA, Virshup DM. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Developmental Cell. 29: 277-91. PMID 24768165 DOI: 10.1016/j.devcel.2014.03.016  1
2013 Xu P, Raetz EA, Kitagawa M, Virshup DM, Lee SH. BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression. Biology Open. 2: 479-86. PMID 23789096 DOI: 10.1242/bio.20134051  1
2013 Yim DG, Virshup DM. Unwinding the Wnt action of casein kinase 1. Cell Research. 23: 737-8. PMID 23567556 DOI: 10.1038/cr.2013.51  1
2013 Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, Hannoush RN, Virshup DM. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Research. 73: 502-7. PMID 23188502 DOI: 10.1158/0008-5472.CAN-12-2258  1
2012 Proffitt KD, Virshup DM. Precise regulation of porcupine activity is required for physiological Wnt signaling. The Journal of Biological Chemistry. 287: 34167-78. PMID 22888000 DOI: 10.1074/jbc.M112.381970  1
2012 Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation; Research in Biological Diversity. 84: 203-13. PMID 22784633 DOI: 10.1016/j.diff.2012.06.004  1
2012 Covey TM, Kaur S, Tan Ong T, Proffitt KD, Wu Y, Tan P, Virshup DM. PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. Plos One. 7: e34532. PMID 22509316 DOI: 10.1371/journal.pone.0034532  1
2012 Coombs GS, Schmitt AA, Canning CA, Alok A, Low IC, Banerjee N, Kaur S, Utomo V, Jones CM, Pervaiz S, Toone EJ, Virshup DM. Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. Oncogene. 31: 213-25. PMID 21666721 DOI: 10.1038/onc.2011.228  1
2011 Ooi CH, Oh HK, Wang HZA, Tan ALK, Wu J, Lee M, Rha SY, Chung HC, Virshup DM, Tan P. A densely interconnected genome-wide network of micrornas and oncogenic pathways revealed using gene expression signatures Plos Genetics. 7. PMID 22194702 DOI: 10.1371/journal.pgen.1002415  1
2011 Cheong JK, Nguyen TH, Wang H, Tan P, Voorhoeve PM, Lee SH, Virshup DM. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/É› and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 30: 2558-69. PMID 21258417 DOI: 10.1038/onc.2010.627  1
2011 Cheong JK, Virshup DM. Casein kinase 1: Complexity in the family. The International Journal of Biochemistry & Cell Biology. 43: 465-9. PMID 21145983 DOI: 10.1016/j.biocel.2010.12.004  1
2010 Virshup DM, Kaldis P. Cell biology. Enforcing the Greatwall in mitosis. Science (New York, N.Y.). 330: 1638-9. PMID 21164006 DOI: 10.1126/science.1199898  1
2010 Covey TM, Edes K, Coombs GS, Virshup DM, Fitzpatrick FA. Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. Plos One. 5: e13545. PMID 20975834 DOI: 10.1371/journal.pone.0013545  1
2010 Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, ... ... Virshup DM, et al. WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. Journal of Cell Science. 123: 3357-67. PMID 20826466 DOI: 10.1242/jcs.072132  1
2009 McCulloch MW, Bugni TS, Concepcion GP, Coombs GS, Harper MK, Kaur S, Mangalindan GC, Mutizwa MM, Veltri CA, Virshup DM, Ireland CM. Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. Journal of Natural Products. 72: 1651-6. PMID 19778090 DOI: 10.1021/np900336f  1
2009 Virshup DM, Forger DB. Keeping the beat in the rising heat. Cell. 137: 602-4. PMID 19450508 DOI: 10.1016/j.cell.2009.04.051  1
2009 Virshup DM, Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Molecular Cell. 33: 537-45. PMID 19285938 DOI: 10.1016/j.molcel.2009.02.015  1
2009 McCulloch MW, Coombs GS, Banerjee N, Bugni TS, Cannon KM, Harper MK, Veltri CA, Virshup DM, Ireland CM. Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorganic & Medicinal Chemistry. 17: 2189-98. PMID 19022675 DOI: 10.1016/j.bmc.2008.10.077  1
2008 Coombs GS, Covey TM, Virshup DM. Wnt signaling in development, disease and translational medicine. Current Drug Targets. 9: 513-31. PMID 18673238 DOI: 10.2174/138945008784911796  1
2008 Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NR, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, et al. Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron. 58: 78-88. PMID 18400165 DOI: 10.1016/j.neuron.2008.01.019  1
2007 Virshup DM, Eide EJ, Forger DB, Gallego M, Harnish EV. Reversible protein phosphorylation regulates circadian rhythms. Cold Spring Harbor Symposia On Quantitative Biology. 72: 413-20. PMID 18419299 DOI: 10.1101/sqb.2007.72.048  1
2007 Forester CM, Maddox J, Louis JV, Goris J, Virshup DM. Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proceedings of the National Academy of Sciences of the United States of America. 104: 19867-72. PMID 18056802 DOI: 10.1073/pnas.0709879104  1
2007 Virshup DM, Forger DB. After hours keeps clock researchers CRYing Overtime. Cell. 129: 857-9. PMID 17540165 DOI: 10.1016/j.cell.2007.05.015  1
2007 Tsai IC, Amack JD, Gao ZH, Band V, Yost HJ, Virshup DM. A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Developmental Cell. 12: 335-47. PMID 17336901 DOI: 10.1016/j.devcel.2007.02.009  1
2007 Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM. Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. The Embo Journal. 26: 1511-21. PMID 17318175 DOI: 10.1038/sj.emboj.7601607  1
2007 Gallego M, Virshup DM. Post-translational modifications regulate the ticking of the circadian clock. Nature Reviews. Molecular Cell Biology. 8: 139-48. PMID 17245414 DOI: 10.1038/nrm2106  1
2007 Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM. Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. International Journal of Cancer. Journal International Du Cancer. 120: 1005-12. PMID 17131344 DOI: 10.1002/ijc.22368  1
2007 Saraf A, Virshup DM, Strack S. Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. The Journal of Biological Chemistry. 282: 573-80. PMID 17085438 DOI: 10.1074/jbc.M607407200  1
2006 Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, ... ... Virshup DM, et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 127: 759-73. PMID 17110335 DOI: 10.1016/j.cell.2006.10.035  1
2006 Klimowski LK, Garcia BA, Shabanowitz J, Hunt DF, Virshup DM. Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. The Febs Journal. 273: 4594-602. PMID 16965538 DOI: 10.1111/j.1742-4658.2006.05462.x  1
2006 Gallego M, Eide EJ, Woolf MF, Virshup DM, Forger DB. An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proceedings of the National Academy of Sciences of the United States of America. 103: 10618-23. PMID 16818876 DOI: 10.1073/pnas.0604511103  1
2006 Gallego M, Kang H, Virshup DM. Protein phosphatase 1 regulates the stability of the circadian protein PER2. The Biochemical Journal. 399: 169-75. PMID 16813562 DOI: 10.1042/BJ20060678  1
2006 Swiatek W, Kang H, Garcia BA, Shabanowitz J, Coombs GS, Hunt DF, Virshup DM. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. The Journal of Biological Chemistry. 281: 12233-41. PMID 16513652 DOI: 10.1074/jbc.M510580200  1
2005 Eide EJ, Kang H, Crapo S, Gallego M, Virshup DM. Casein kinase I in the mammalian circadian clock. Methods in Enzymology. 393: 408-18. PMID 15817302 DOI: 10.1016/S0076-6879(05)93019-X  1
2005 Gallego M, Virshup DM. Protein serine/threonine phosphatases: life, death, and sleeping. Current Opinion in Cell Biology. 17: 197-202. PMID 15780597 DOI: 10.1016/j.ceb.2005.01.002  1
2005 Eide EJ, Woolf MF, Kang H, Woolf P, Hurst W, Camacho F, Vielhaber EL, Giovanni A, Virshup DM. Control of mammalian circadian rhythm by CKIε-regulated proteasome-mediated PER2 degradation Molecular and Cellular Biology. 25: 2795-2807. PMID 15767683 DOI: 10.1128/MCB.25.7.2795-2807.2005  1
2005 Firulli BA, Krawchuk D, Centonze VE, Vargesson N, Virshup DM, Conway SJ, Cserjesi P, Laufer E, Firulli AB. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nature Genetics. 37: 373-81. PMID 15735646 DOI: 10.1038/ng1525  1
2004 Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A. A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Molecular and Cellular Biology. 24: 4184-95. PMID 15121840 DOI: 10.1128/MCB.24.10.4184-4195.2004  1
2004 Firulli BA, Virshup DM, Firulli AB. Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines. Biological Procedures Online. 6: 16-22. PMID 15103396 DOI: 10.1251/bpo69  1
2004 Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM. Regulation of casein kinase I epsilon activity by Wnt signaling. The Journal of Biological Chemistry. 279: 13011-7. PMID 14722104 DOI: 10.1074/jbc.M304682200  1
2003 Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Molecular Cell. 12: 1225-37. PMID 14636580 DOI: 10.1016/S1097-2765(03)00425-8  1
2002 Liu Y, Virshup DM, White RL, Hsu LC. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Research. 62: 6357-61. PMID 12438214  1
2002 Liu F, Virshup DM, Nairn AC, Greengard P. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. The Journal of Biological Chemistry. 277: 45393-9. PMID 12223474 DOI: 10.1074/jbc.M204499200  1
2002 Raetz EA, Perkins SL, Carlson MA, Schooler KP, Carroll WL, Virshup DM. The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas American Journal of Pathology. 161: 875-883. PMID 12213716  1
2002 Li X, Scuderi A, Letsou A, Virshup DM. B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Molecular and Cellular Biology. 22: 3674-84. PMID 11997504 DOI: 10.1128/MCB.22.11.3674-3684.2002  1
2002 Eide EJ, Vielhaber EL, Hinz WA, Virshup DM. The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. The Journal of Biological Chemistry. 277: 17248-54. PMID 11875063 DOI: 10.1074/jbc.M111466200  1
2002 Li X, Virshup DM. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. European Journal of Biochemistry / Febs. 269: 546-52. PMID 11856313 DOI: 10.1046/j.0014-2956.2001.02680.x  1
2002 Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proceedings of the National Academy of Sciences of the United States of America. 99: 1182-7. PMID 11818547 DOI: 10.1073/pnas.032468199  1
2001 Vielhaber EL, Duricka D, Ullman KS, Virshup DM. Nuclear Export of Mammalian PERIOD Proteins Journal of Biological Chemistry. 276: 45921-45927. PMID 11591712 DOI: 10.1074/jbc.M107726200  1
2001 Li X, Yost HJ, Virshup DM, Seeling JM. Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. The Embo Journal. 20: 4122-31. PMID 11483515 DOI: 10.1093/emboj/20.15.4122  1
2001 Eide EJ, Virshup DM. Casein kinase I: another cog in the circadian clockworks. Chronobiology International. 18: 389-98. PMID 11475410 DOI: 10.1081/CBI-100103963  1
2001 Vielhaber E, Virshup DM. Casein kinase I: From obscurity to center stage Iubmb Life. 51: 73-78. PMID 11463166  1
2001 Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptácek LJ, Fu YH. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (New York, N.Y.). 291: 1040-3. PMID 11232563 DOI: 10.1126/science.1057499  1
2001 Camacho F, Cilio M, Guo Y, Virshup DM, Patel K, Khorkova O, Styren S, Morse B, Yao Z, Keesler GA. Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2 Febs Letters. 489: 159-165. PMID 11165242 DOI: 10.1016/S0014-5793(00)02434-0  1
2000 Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM. Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε Molecular and Cellular Biology. 20: 4888-4899. PMID 10848614 DOI: 10.1128/MCB.20.13.4888-4899.2000  1
2000 Virshup DM. Protein phosphatase 2A: A panoply of enzymes Current Opinion in Cell Biology. 12: 180-185. PMID 10712915 DOI: 10.1016/S0955-0674(99)00074-5  1
2000 Gao ZH, Metherall J, Virshup DM. Identification of casein kinase I substrates by in vitro expression cloning screening Biochemical and Biophysical Research Communications. 268: 562-566. PMID 10679243 DOI: 10.1006/bbrc.2000.2168  1
1999 Gietzen KF, Virshup DM. Identification of inhibitory autophosphorylation sites in casein kinase I ε Journal of Biological Chemistry. 274: 32063-32070. PMID 10542239 DOI: 10.1074/jbc.274.45.32063  1
1999 Goldsby RE, Perkins SL, Virshup DM, Brothman AR, Bruggers CS. Lymphoblastic lymphoma and excessive toxicity from chemotherapy: An unusual presentation for fanconi anemia Journal of Pediatric Hematology/Oncology. 21: 240-243. PMID 10363859 DOI: 10.1097/00043426-199905000-00014  1
1999 Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM. Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A Science. 283: 2089-2091. PMID 10092233 DOI: 10.1126/science.283.5410.2089  1
1998 McCright B, Virshup DM. Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method Methods in Molecular Biology (Clifton, N.J.). 93: 263-277. PMID 9664544  1
1998 Rivers A, Gietzen KF, Vielhaber E, Virshup DM. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. The Journal of Biological Chemistry. 273: 15980-4. PMID 9632646 DOI: 10.1074/jbc.273.26.15980  1
1998 Cegielska A, Gietzen KF, Rivers A, Virshup DM. Autoinhibition of casein kinase I ε (CKIε) is relieved by protein phosphatases and limited proteolysis Journal of Biological Chemistry. 273: 1357-1364. PMID 9430669 DOI: 10.1074/jbc.273.3.1357  1
1997 Gietzen KJ, Virshup DM. Determinants of casein kinase i epsilon (ckir) autoinhibition Faseb Journal. 11.  1
1996 McCright B, Brothman AR, Virshup DM. Assignment of human protein phosphatase 2A regulatory subunit genes B56α, B56β, B56γ, B56δ, and B56ε (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 → p12 Genomics. 36: 168-170. PMID 8812429 DOI: 10.1006/geno.1996.0438  1
1996 McCright B, Rivers AM, Audlin S, Virshup DM. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm Journal of Biological Chemistry. 271: 22081-22089. PMID 8703017 DOI: 10.1074/jbc.271.36.22081  1
1995 Sivak LE, Virshup DM. Occurrence of Henoch-Schonlein purpura in a child with Wilms' tumor Medical and Pediatric Oncology. 24: 213-214. PMID 7838045 DOI: 10.1002/mpo.2950240314  1
1995 Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM. Isolation and characterization of human casein kinase I∈ (CKI), a novel member of the CKI gene family Journal of Biological Chemistry. 270: 14875-14883. PMID 7797465  1
1995 McCright B, Virshup DM. Identification of a new family of protein phosphatase 2A regulatory subunits Journal of Biological Chemistry. 270: 26123-26128. PMID 7592815 DOI: 10.1074/jbc.270.44.26123  1
1994 Cegielska A, Moarefi I, Fanning E, Virshup DM. T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123 Journal of Virology. 68: 269-275. PMID 8254738  1
1994 Cegielska A, Shaffer S, Derua R, Goris J, Virshup DM. Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication Molecular and Cellular Biology. 14: 4616-4623. PMID 8007966  1
1993 Cegielska A, Virshup DM. Control of Simian Virus 40 DNA Replication by the HeLa Cell Nuclear Kinase Casein Kinase I Molecular and Cellular Biology. 13: 1202-1211. PMID 8380893  1
1992 Virshup DM, Russo AA, Kelly TJ. Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. Molecular and Cellular Biology. 12: 4883-95. PMID 1328866  1
1991 Modlin JF, Dagan R, Berlin LE, Virshup DM, Yolken RH, Menegus M. Focal encephalitis with enterovirus infections. Pediatrics. 88: 841-5. PMID 1896296  1
1991 Scheidtmann KH, Virshup DM, Kelly TJ. Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity. Journal of Virology. 65: 2098-101. PMID 1848320  1
1990 Weinberg DH, Collins KL, Simancek P, Russo A, Wold MS, Virshup DM, Kelly TJ. Reconstitution of simian virus 40 DNA replication with purified proteins. Proceedings of the National Academy of Sciences of the United States of America. 87: 8692-6. PMID 2174160 DOI: 10.1073/pnas.87.22.8692  1
1990 Virshup DM. DNA replication Current Opinion in Cell Biology. 2: 453-460. PMID 2165792 DOI: 10.1016/0955-0674(90)90127-Z  1
1989 Moo-Penn WF, Swan DC, Hine TK, Baine RM, Jue DL, Benson JM, Johnson MH, Virshup DM, Zinkham WH. Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? The Journal of Biological Chemistry. 264: 21454-7. PMID 2574721  1
1989 Virshup DM, Kauffman MG, Kelly TJ. Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. The Embo Journal. 8: 3891-8. PMID 2555176  1
1989 Virshup DM, Kelly TJ. Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro. Proceedings of the National Academy of Sciences of the United States of America. 86: 3584-8. PMID 2542940  1
1989 Wold MS, Weinberg DH, Virshup DM, Li JJ, Kelly TJ. Identification of cellular proteins required for simian virus 40 DNA replication. The Journal of Biological Chemistry. 264: 2801-9. PMID 2536723  1
1988 Virshup DM, Bennett V. Clathrin-coated vesicle assembly polypeptides: Physical properties and reconstitution studies with brain membranes Journal of Cell Biology. 106: 39-50. PMID 2892842 DOI: 10.1083/jcb.106.1.39  1
1987 Jerdan MS, Shapiro RS, Smith NB, Virshup DM, Hood AF. Cutaneous manifestations of Corynebacterium group JK sepsis Journal of the American Academy of Dermatology. 16: 444-447. PMID 3469229 DOI: 10.1016/S0190-9622(87)70058-9  1
1983 Virshup DM, Zinkham WH, Sirota RL, Caughey WS. Unique sensitivity of Hb Zurich to oxidative injury by phenazopyridine: Reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro American Journal of Hematology. 14: 315-324. PMID 6859031  1
1982 Virshup DM, Zinkham Wm. H, Sirota RL, Caughey WS. Unique sensitivity of HB Zurich to oxidative injury by phenazopyridine: Reversal of the effect by elevating carboxyhemoglobin levels in vivo and in vitro Pediatric Research. 16: No. 830.  1
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