| Year |
Citation |
Score |
| 2023 |
Tsai CN, Massicotte MA, MacNair CR, Perry JN, Brown ED, Coombes BK. Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal (iNTS). Rsc Chemical Biology. 4: 600-612. PMID 37547457 DOI: 10.1039/d3cb00014a |
0.329 |
|
| 2022 |
Popov G, Fiebig-Comyn A, Syriste L, Little DJ, Skarina T, Stogios PJ, Birstonas S, Coombes BK, Savchenko A. Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice. Infection and Immunity. e0050522. PMID 36511702 DOI: 10.1128/iai.00505-22 |
0.312 |
|
| 2021 |
Elhenawy W, Hordienko S, Gould S, Oberc AM, Tsai CN, Hubbard TP, Waldor MK, Coombes BK. High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli. Nature Communications. 12: 2032. PMID 33795670 DOI: 10.1038/s41467-021-22306-w |
0.328 |
|
| 2020 |
Chau NYE, Pérez-Morales D, Elhenawy W, Bustamante VH, Zhang YE, Coombes BK. (p)ppGpp-dependent regulation of the nucleotide hydrolase PpnN confers complement resistance in serovar Typhimurium. Infection and Immunity. PMID 33139383 DOI: 10.1128/IAI.00639-20 |
0.329 |
|
| 2020 |
Weber BS, De Jong AM, Guo ABY, Dharavath S, French S, Fiebig-Comyn AA, Coombes BK, Magolan J, Brown ED. Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae. Cell Reports. 32: 107927. PMID 32698013 DOI: 10.1016/J.Celrep.2020.107927 |
0.344 |
|
| 2020 |
Tsai CN, MacNair CR, Cao MPT, Perry JN, Magolan J, Brown ED, Coombes BK. Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence. Cell Chemical Biology. PMID 32413287 DOI: 10.1016/J.Chembiol.2020.04.005 |
0.44 |
|
| 2020 |
Culp EJ, Waglechner N, Wang W, Fiebig-Comyn AA, Hsu YP, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV, Wright GD. Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature. PMID 32051588 DOI: 10.1038/S41586-020-1990-9 |
0.372 |
|
| 2019 |
Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED. Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Nature Microbiology. PMID 31659298 DOI: 10.1038/S41564-019-0595-2 |
0.405 |
|
| 2019 |
Shaler CR, Elhenawy W, Coombes BK. The Unique Lifestyle of Crohn's Disease-Associated Adherent Invasive Escherichia coli. Journal of Molecular Biology. PMID 31029703 DOI: 10.1016/J.Jmb.2019.04.023 |
0.41 |
|
| 2019 |
Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, et al. Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Nature Communications. 10: 1198. PMID 30867416 DOI: 10.1038/S41467-019-09037-9 |
0.393 |
|
| 2019 |
Ladinsky MS, Araujo LP, Zhang X, Veltri J, Galan-Diez M, Soualhi S, Lee C, Irie K, Pinker EY, Narushima S, Bandyopadhyay S, Nagayama M, Elhenawy W, Coombes BK, Ferraris RP, et al. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science (New York, N.Y.). 363. PMID 30846568 DOI: 10.1126/Science.Aat4042 |
0.385 |
|
| 2019 |
Tsai CN, Coombes BK. The Role of the Host in Driving Phenotypic Heterogeneity in Salmonella. Trends in Microbiology. PMID 30755344 DOI: 10.1016/J.Tim.2019.01.004 |
0.475 |
|
| 2019 |
Elhenawy W, Tsai CN, Coombes BK. Host-Specific Adaptive Diversification of Crohn's Disease-Associated Adherent-Invasive Escherichia coli. Cell Host & Microbe. PMID 30683582 DOI: 10.1016/J.Chom.2018.12.010 |
0.39 |
|
| 2019 |
Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK, Brown ED. A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium. Nature Communications. 10: 197. PMID 30643129 DOI: 10.1038/S41467-018-08190-X |
0.399 |
|
| 2018 |
Oberc AM, Fiebig-Comyn AA, Tsai CN, Elhenawy W, Coombes BK. Antibiotics Potentiate Adherent-Invasive E. coli Infection and Expansion. Inflammatory Bowel Diseases. PMID 30496418 DOI: 10.1093/Ibd/Izy361 |
0.39 |
|
| 2018 |
Ilyas B, Mulder DT, Little DJ, Elhenawy W, Banda MM, Pérez-Morales D, Tsai CN, Chau NYE, Bustamante VH, Coombes BK. Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium. Cell Reports. 25: 825-832.e5. PMID 30355489 DOI: 10.1016/J.Celrep.2018.09.078 |
0.459 |
|
| 2018 |
Valleau D, Little DJ, Borek D, Skarina T, Quaile AT, Di Leo R, Houliston S, Lemak A, Arrowsmith CH, Coombes BK, Savchenko A. Functional diversification of the NleG effector family in enterohemorrhagic . Proceedings of the National Academy of Sciences of the United States of America. PMID 30217892 DOI: 10.1073/Pnas.1718350115 |
0.419 |
|
| 2018 |
Little DJ, Coombes BK. Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli. Plos Pathogens. 14: e1007224. PMID 30118511 DOI: 10.1371/Journal.Ppat.1007224 |
0.322 |
|
| 2018 |
MacNair CR, Stokes JM, Carfrae LA, Fiebig-Comyn AA, Coombes BK, Mulvey MR, Brown ED. Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nature Communications. 9: 458. PMID 29386620 DOI: 10.1038/S41467-018-02875-Z |
0.376 |
|
| 2017 |
Ilyas B, Tsai CN, Coombes BK. Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome. Frontiers in Cellular and Infection Microbiology. 7: 428. PMID 29034217 DOI: 10.3389/Fcimb.2017.00428 |
0.468 |
|
| 2017 |
Elhenawy W, Oberc A, Coombes BK. A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli. Gut Microbes. 0. PMID 28914579 DOI: 10.1080/19490976.2017.1378291 |
0.36 |
|
| 2017 |
Pérez-Morales D, Banda MM, Chau NYE, Salgado H, Martínez-Flores I, Ibarra JA, Ilyas B, Coombes BK, Bustamante VH. The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella. Plos Pathogens. 13: e1006497. PMID 28704543 DOI: 10.1371/Journal.Ppat.1006497 |
0.459 |
|
| 2017 |
Stokes JM, MacNair CR, Ilyas B, French S, Côté JP, Bouwman C, Farha MA, Sieron AO, Whitfield C, Coombes BK, Brown ED. Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nature Microbiology. 2: 17028. PMID 28263303 DOI: 10.1038/Nmicrobiol.2017.28 |
0.399 |
|
| 2016 |
Coombes BK. Bacterial evolution: Making a host-adapted bacterium. Nature Microbiology. 1: 16010. PMID 27572171 DOI: 10.1038/Nmicrobiol.2016.10 |
0.443 |
|
| 2015 |
Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED. Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. Acs Infectious Diseases. 1: 533-543. PMID 27623408 DOI: 10.1021/Acsinfecdis.5B00033 |
0.335 |
|
| 2015 |
Oberc A, Coombes BK. Convergence of External Crohn's Disease Risk Factors on Intestinal Bacteria. Frontiers in Immunology. 6: 558. PMID 26579131 DOI: 10.3389/Fimmu.2015.00558 |
0.33 |
|
| 2015 |
Ferreira RB, Valdez Y, Coombes BK, Sad S, Gouw JW, Brown EM, Li Y, Grassl GA, Antunes LC, Gill N, Truong M, Scholz R, Reynolds LA, Krishnan L, Zafer AA, et al. A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections. Mbio. 6. PMID 26396246 DOI: 10.1128/Mbio.01421-15 |
0.356 |
|
| 2015 |
Reid-Yu SA, Tuinema BR, Small CN, Xing L, Coombes BK. CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling. Plos Pathogens. 11: e1004648. PMID 25643352 DOI: 10.1371/Journal.Ppat.1004648 |
0.475 |
|
| 2015 |
Mulder DT, McPhee JB, Reid-Yu SA, Stogios PJ, Savchenko A, Coombes BK. Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification. Molecular Microbiology. 95: 678-91. PMID 25442048 DOI: 10.1111/Mmi.12895 |
0.33 |
|
| 2014 |
Tuinema BR, Reid-Yu SA, Coombes BK. Salmonella evades D-amino acid oxidase to promote infection in neutrophils. Mbio. 5: e01886. PMID 25425233 DOI: 10.1128/Mbio.01886-14 |
0.415 |
|
| 2014 |
Allison SE, Tuinema BR, Everson ES, Sugiman-Marangos S, Zhang K, Junop MS, Coombes BK. Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo. The Journal of Biological Chemistry. 289: 23734-44. PMID 25035427 DOI: 10.1074/Jbc.M114.578476 |
0.366 |
|
| 2014 |
King AM, Reid-Yu SA, Wang W, King DT, De Pascale G, Strynadka NC, Walsh TR, Coombes BK, Wright GD. Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 510: 503-6. PMID 24965651 DOI: 10.1038/Nature13445 |
0.377 |
|
| 2014 |
McPhee JB, Small CL, Reid-Yu SA, Brannon JR, Le Moual H, Coombes BK. Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli. Infection and Immunity. 82: 3383-93. PMID 24866805 DOI: 10.1128/Iai.01888-14 |
0.437 |
|
| 2013 |
Cooper CA, Mulder DT, Allison SE, Pilar AV, Coombes BK. The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. Bmc Microbiology. 13: 221. PMID 24090070 DOI: 10.1186/1471-2180-13-221 |
0.461 |
|
| 2013 |
Nguyen T, Robinson N, Allison SE, Coombes BK, Sad S, Krishnan L. IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium. Placenta. 34: 765-74. PMID 23834952 DOI: 10.1016/J.Placenta.2013.06.003 |
0.416 |
|
| 2013 |
Reid-Yu SA, Small CL, Coombes BK. CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen. European Journal of Immunology. 43: 2638-49. PMID 23775576 DOI: 10.1002/Eji.201343435 |
0.465 |
|
| 2013 |
Coombes BK. Regulatory evolution at the host-pathogen interface. Canadian Journal of Microbiology. 59: 365-7. PMID 23750949 DOI: 10.1139/Cjm-2013-0300 |
0.417 |
|
| 2013 |
Small CL, Reid-Yu SA, McPhee JB, Coombes BK. Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis. Nature Communications. 4: 1957. PMID 23748852 DOI: 10.1038/Ncomms2957 |
0.425 |
|
| 2013 |
Tomljenovic-Berube AM, Henriksbo B, Porwollik S, Cooper CA, Tuinema BR, McClelland M, Coombes BK. Mapping and regulation of genes within Salmonella pathogenicity island 12 that contribute to in vivo fitness of Salmonella enterica Serovar Typhimurium. Infection and Immunity. 81: 2394-404. PMID 23630960 DOI: 10.1128/Iai.00067-13 |
0.442 |
|
| 2013 |
Mulder DT, Coombes BK. Infection biology: Cheats never prosper. Nature. 494: 321-2. PMID 23426321 DOI: 10.1038/494321A |
0.485 |
|
| 2013 |
Pilar AV, Reid-Yu SA, Cooper CA, Mulder DT, Coombes BK. Active modification of host inflammation by Salmonella. Gut Microbes. 4: 140-5. PMID 23333857 DOI: 10.4161/Gmic.23361 |
0.447 |
|
| 2012 |
Allison SE, Silphaduang U, Mascarenhas M, Konczy P, Quan Q, Karmali M, Coombes BK. Novel repressor of Escherichia coli O157:H7 motility encoded in the putative fimbrial cluster OI-1. Journal of Bacteriology. 194: 5343-52. PMID 22843849 DOI: 10.1128/Jb.01025-12 |
0.34 |
|
| 2012 |
Pilar AV, Reid-Yu SA, Cooper CA, Mulder DT, Coombes BK. GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1. Plos Pathogens. 8: e1002773. PMID 22761574 DOI: 10.1371/Journal.Ppat.1002773 |
0.474 |
|
| 2012 |
Mulder DT, Cooper CA, Coombes BK. Type VI secretion system-associated gene clusters contribute to pathogenesis of Salmonella enterica serovar Typhimurium. Infection and Immunity. 80: 1996-2007. PMID 22493086 DOI: 10.1128/Iai.06205-11 |
0.469 |
|
| 2012 |
Osborne SE, Tuinema BR, Mok MC, Lau PS, Bui NK, Tomljenovic-Berube AM, Vollmer W, Zhang K, Junop M, Coombes BK. Characterization of DalS, an ATP-binding cassette transporter for D-alanine, and its role in pathogenesis in Salmonella enterica. The Journal of Biological Chemistry. 287: 15242-50. PMID 22418438 DOI: 10.1074/Jbc.M112.348227 |
0.463 |
|
| 2011 |
Bos KI, Schuenemann VJ, Golding GB, Burbano HA, Waglechner N, Coombes BK, McPhee JB, DeWitte SN, Meyer M, Schmedes S, Wood J, Earn DJ, Herring DA, Bauer P, Poinar HN, et al. A draft genome of Yersinia pestis from victims of the Black Death. Nature. 478: 506-10. PMID 21993626 DOI: 10.1038/Nature10549 |
0.38 |
|
| 2011 |
Schuenemann VJ, Bos K, DeWitte S, Schmedes S, Jamieson J, Mittnik A, Forrest S, Coombes BK, Wood JW, Earn DJ, White W, Krause J, Poinar HN. Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death. Proceedings of the National Academy of Sciences of the United States of America. 108: E746-52. PMID 21876176 DOI: 10.1073/Pnas.1105107108 |
0.359 |
|
| 2011 |
Pilar AV, Coombes BK. A Fresh Look at the Type III Secretion System: Two-Step Model of Effector Translocation in Pathogenic Bacteria. Frontiers in Microbiology. 2: 113. PMID 21833340 DOI: 10.3389/Fmicb.2011.00113 |
0.484 |
|
| 2011 |
Coombes BK, Gilmour MW, Goodman CD. The evolution of virulence in non-o157 shiga toxin-producing Escherichia coli. Frontiers in Microbiology. 2: 90. PMID 21833329 DOI: 10.3389/Fmicb.2011.00090 |
0.323 |
|
| 2011 |
Osborne SE, Coombes BK. Transcriptional priming of Salmonella Pathogenicity Island-2 precedes cellular invasion. Plos One. 6: e21648. PMID 21738750 DOI: 10.1371/Journal.Pone.0021648 |
0.479 |
|
| 2011 |
Wallar LE, Bysice AM, Coombes BK. The non-motile phenotype of Salmonella hha ydgT mutants is mediated through PefI-SrgD. Bmc Microbiology. 11: 141. PMID 21689395 DOI: 10.1186/1471-2180-11-141 |
0.433 |
|
| 2011 |
Sepehri S, Khafipour E, Bernstein CN, Coombes BK, Pilar AV, Karmali M, Ziebell K, Krause DO. Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 17: 1451-63. PMID 21674703 DOI: 10.1002/Ibd.21509 |
0.307 |
|
| 2011 |
Mian MF, Pek EA, Chenoweth MJ, Coombes BK, Ashkar AA. Humanized mice for Salmonella typhi infection: new tools for an old problem. Virulence. 2: 248-52. PMID 21623167 DOI: 10.4161/Viru.2.3.16133 |
0.388 |
|
| 2011 |
Auweter SD, Bhavsar AP, de Hoog CL, Li Y, Chan YA, van der Heijden J, Lowden MJ, Coombes BK, Rogers LD, Stoynov N, Foster LJ, Finlay BB. Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners. The Journal of Biological Chemistry. 286: 24023-35. PMID 21566117 DOI: 10.1074/Jbc.M111.224600 |
0.492 |
|
| 2011 |
Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nature Chemical Biology. 7: 348-50. PMID 21516114 DOI: 10.1038/Nchembio.559 |
0.305 |
|
| 2011 |
Brown NF, Coombes BK, Bishop JL, Wickham ME, Lowden MJ, Gal-Mor O, Goode DL, Boyle EC, Sanderson KL, Finlay BB. Salmonella phage ST64B encodes a member of the SseK/NleB effector family. Plos One. 6: e17824. PMID 21445262 DOI: 10.1371/Journal.Pone.0017824 |
0.473 |
|
| 2011 |
Osborne SE, Coombes BK. Expression and secretion hierarchy in the nonflagellar type III secretion system. Future Microbiology. 6: 193-202. PMID 21366419 DOI: 10.2217/Fmb.10.172 |
0.425 |
|
| 2010 |
Nash JH, Villegas A, Kropinski AM, Aguilar-Valenzuela R, Konczy P, Mascarenhas M, Ziebell K, Torres AG, Karmali MA, Coombes BK. Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes. Bmc Genomics. 11: 667. PMID 21108814 DOI: 10.1186/1471-2164-11-667 |
0.375 |
|
| 2010 |
Wu B, Skarina T, Yee A, Jobin MC, Dileo R, Semesi A, Fares C, Lemak A, Coombes BK, Arrowsmith CH, Singer AU, Savchenko A. NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. Plos Pathogens. 6: e1000960. PMID 20585566 DOI: 10.1371/Journal.Ppat.1000960 |
0.318 |
|
| 2010 |
Tomljenovic-Berube AM, Mulder DT, Whiteside MD, Brinkman FS, Coombes BK. Identification of the regulatory logic controlling Salmonella pathoadaptation by the SsrA-SsrB two-component system. Plos Genetics. 6: e1000875. PMID 20300643 DOI: 10.1371/Journal.Pgen.1000875 |
0.394 |
|
| 2010 |
Cooper CA, Zhang K, Andres SN, Fang Y, Kaniuk NA, Hannemann M, Brumell JH, Foster LJ, Junop MS, Coombes BK. Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host. Plos Pathogens. 6: e1000751. PMID 20140193 DOI: 10.1371/Journal.Ppat.1000751 |
0.491 |
|
| 2009 |
Johnson DL, Stone CB, Bulir DC, Coombes BK, Mahony JB. A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication. Bmc Microbiology. 9: 218. PMID 19828035 DOI: 10.1186/1471-2180-9-218 |
0.525 |
|
| 2009 |
Wong CE, Sad S, Coombes BK. Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction. Infection and Immunity. 77: 4750-60. PMID 19720755 DOI: 10.1128/Iai.00545-09 |
0.455 |
|
| 2009 |
Osborne SE, Coombes BK. RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in Salmonella enterica serovar Typhimurium. Bmc Microbiology. 9: 45. PMID 19245712 DOI: 10.1186/1471-2180-9-45 |
0.399 |
|
| 2009 |
Osborne SE, Walthers D, Tomljenovic AM, Mulder DT, Silphaduang U, Duong N, Lowden MJ, Wickham ME, Waller RF, Kenney LJ, Coombes BK. Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function. Proceedings of the National Academy of Sciences of the United States of America. 106: 3982-7. PMID 19234126 DOI: 10.1073/Pnas.0811669106 |
0.401 |
|
| 2009 |
Coombes BK. Type III secretion systems in symbiotic adaptation of pathogenic and non-pathogenic bacteria. Trends in Microbiology. 17: 89-94. PMID 19217298 DOI: 10.1016/J.Tim.2008.11.006 |
0.432 |
|
| 2009 |
Szeto J, Namolovan A, Osborne SE, Coombes BK, Brumell JH. Salmonella-containing vacuoles display centrifugal movement associated with cell-to-cell transfer in epithelial cells. Infection and Immunity. 77: 996-1007. PMID 19103768 DOI: 10.1128/Iai.01275-08 |
0.454 |
|
| 2009 |
Ashkar AA, Reid S, Verdu EF, Zhang K, Coombes BK. Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues. Infection and Immunity. 77: 214-22. PMID 19015253 DOI: 10.1128/Iai.01066-08 |
0.36 |
|
| 2009 |
Dong T, Coombes BK, Schellhorn HE. Role of RpoS in the virulence of Citrobacter rodentium. Infection and Immunity. 77: 501-7. PMID 18981255 DOI: 10.1128/Iai.00850-08 |
0.43 |
|
| 2008 |
Ashkar AA, Mossman KL, Coombes BK, Gyles CL, Mackenzie R. FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. Plos Pathogens. 4: e1000233. PMID 19057665 DOI: 10.1371/Journal.Ppat.1000233 |
0.344 |
|
| 2008 |
Weir EK, Martin LC, Poppe C, Coombes BK, Boerlin P. Subinhibitory concentrations of tetracycline affect virulence gene expression in a multi-resistant Salmonella enterica subsp. enterica serovar Typhimurium DT104. Microbes and Infection / Institut Pasteur. 10: 901-7. PMID 18656407 DOI: 10.1016/J.Micinf.2008.05.005 |
0.424 |
|
| 2008 |
Hu Q, Coburn B, Deng W, Li Y, Shi X, Lan Q, Wang B, Coombes BK, Finlay BB. Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1. Journal of Clinical Microbiology. 46: 1330-6. PMID 18272702 DOI: 10.1128/Jcm.01255-07 |
0.403 |
|
| 2008 |
Coombes BK, Wickham ME, Mascarenhas M, Gruenheid S, Finlay BB, Karmali MA. Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains. Applied and Environmental Microbiology. 74: 2153-60. PMID 18245257 DOI: 10.1128/Aem.02566-07 |
0.309 |
|
| 2007 |
Duong N, Osborne S, Bustamante VH, Tomljenovic AM, Puente JL, Coombes BK. Thermosensing coordinates a cis-regulatory module for transcriptional activation of the intracellular virulence system in Salmonella enterica serovar Typhimurium. The Journal of Biological Chemistry. 282: 34077-84. PMID 17895240 DOI: 10.1074/Jbc.M707352200 |
0.444 |
|
| 2007 |
Wickham ME, Brown NF, Provias J, Finlay BB, Coombes BK. Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain. Bmc Infectious Diseases. 7: 65. PMID 17597539 DOI: 10.1186/1471-2334-7-65 |
0.378 |
|
| 2007 |
Wickham ME, Brown NF, Boyle EC, Coombes BK, Finlay BB. Virulence is positively selected by transmission success between mammalian hosts. Current Biology : Cb. 17: 783-8. PMID 17442572 DOI: 10.1016/J.Cub.2007.03.067 |
0.481 |
|
| 2007 |
Baron C, Coombes B. Targeting bacterial secretion systems: benefits of disarmament in the microcosm. Infectious Disorders Drug Targets. 7: 19-27. PMID 17346208 DOI: 10.2174/187152607780090685 |
0.445 |
|
| 2007 |
Wickham ME, Lupp C, Vázquez A, Mascarenhas M, Coburn B, Coombes BK, Karmali MA, Puente JL, Deng W, Finlay BB. Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE. Microbes and Infection / Institut Pasteur. 9: 400-7. PMID 17317262 DOI: 10.1016/J.Micinf.2006.12.016 |
0.43 |
|
| 2007 |
Silphaduang U, Mascarenhas M, Karmali M, Coombes BK. Repression of intracellular virulence factors in Salmonella by the Hha and YdgT nucleoid-associated proteins. Journal of Bacteriology. 189: 3669-73. PMID 17307861 DOI: 10.1128/Jb.00002-07 |
0.442 |
|
| 2007 |
Coombes BK, Lowden MJ, Bishop JL, Wickham ME, Brown NF, Duong N, Osborne S, Gal-Mor O, Finlay BB. SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system. Infection and Immunity. 75: 574-80. PMID 17158898 DOI: 10.1128/Iai.00985-06 |
0.53 |
|
| 2006 |
Wickham ME, Lupp C, Mascarenhas M, Vazquez A, Coombes BK, Brown NF, Coburn BA, Deng W, Puente JL, Karmali MA, Finlay BB. Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection. The Journal of Infectious Diseases. 194: 819-27. PMID 16941350 DOI: 10.1086/506620 |
0.367 |
|
| 2006 |
Brown NF, Szeto J, Jiang X, Coombes BK, Finlay BB, Brumell JH. Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function. Microbiology (Reading, England). 152: 2323-43. PMID 16849798 DOI: 10.1099/Mic.0.28995-0 |
0.41 |
|
| 2006 |
Brown NF, Wickham ME, Coombes BK, Finlay BB. Crossing the line: selection and evolution of virulence traits. Plos Pathogens. 2: e42. PMID 16733541 DOI: 10.1371/Journal.Ppat.0020042 |
0.406 |
|
| 2005 |
Brown NF, Vallance BA, Coombes BK, Valdez Y, Coburn BA, Finlay BB. Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine. Plos Pathogens. 1: e32. PMID 16304611 DOI: 10.1371/Journal.Ppat.0010032 |
0.442 |
|
| 2005 |
Coombes BK, Wickham ME, Lowden MJ, Brown NF, Finlay BB. Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid. Proceedings of the National Academy of Sciences of the United States of America. 102: 17460-5. PMID 16301528 DOI: 10.1073/Pnas.0505401102 |
0.478 |
|
| 2005 |
Coombes BK, Coburn BA, Potter AA, Gomis S, Mirakhur K, Li Y, Finlay BB. Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis. Infection and Immunity. 73: 7161-9. PMID 16239510 DOI: 10.1128/Iai.73.11.7161-7169.2005 |
0.389 |
|
| 2005 |
Coombes BK, Wickham ME, Brown NF, Lemire S, Bossi L, Hsiao WW, Brinkman FS, Finlay BB. Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage. Journal of Molecular Biology. 348: 817-30. PMID 15843015 DOI: 10.1016/J.Jmb.2005.03.024 |
0.494 |
|
| 2005 |
Coombes BK, Finlay BB. Insertion of the bacterial type III translocon: not your average needle stick. Trends in Microbiology. 13: 92-5. PMID 15737725 DOI: 10.1016/J.Tim.2005.01.008 |
0.393 |
|
| 2004 |
Coombes BK, Valdez Y, Finlay BB. Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses. Current Biology : Cb. 14: R856-67. PMID 15458668 DOI: 10.1016/J.Cub.2004.09.043 |
0.409 |
|
| 2004 |
Coombes BK, Brown NF, Valdez Y, Brumell JH, Finlay BB. Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL. The Journal of Biological Chemistry. 279: 49804-15. PMID 15383528 DOI: 10.1074/Jbc.M404299200 |
0.416 |
|
| 2004 |
Coombes BK, Hardwidge PR, Finlay BB. Interpreting the host-pathogen dialogue through microarrays. Advances in Applied Microbiology. 54: 291-331. PMID 15251285 DOI: 10.1016/S0065-2164(04)54011-X |
0.471 |
|
| 2003 |
Coombes BK, Brown NF, Kujat-Choy S, Vallance BA, Finlay BB. SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells. Microbes and Infection / Institut Pasteur. 5: 561-70. PMID 12787732 DOI: 10.1016/S1286-4579(03)00094-7 |
0.475 |
|
| 2002 |
Coombes BK, Johnson DL, Mahony JB. Strategic targeting of essential host-pathogen interactions in chlamydial disease. Current Drug Targets. Infectious Disorders. 2: 201-16. PMID 12462125 DOI: 10.2174/1568005023342362 |
0.649 |
|
| 2002 |
Coombes BK, Mahony JB. Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells. Cellular Microbiology. 4: 447-60. PMID 12102690 DOI: 10.1046/J.1462-5822.2002.00203.X |
0.588 |
|
| 2002 |
Coombes BK, Chiu B, Fong IW, Mahony JB. Chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-B: a potential link to intimal thickening in a rabbit model of atherosclerosis. The Journal of Infectious Diseases. 185: 1621-30. PMID 12023768 DOI: 10.1086/340415 |
0.575 |
|
| 2001 |
Coombes BK, Mahony JB. Dendritic cell discoveries provide new insight into the cellular immunobiology of DNA vaccines. Immunology Letters. 78: 103-11. PMID 11672594 DOI: 10.1016/S0165-2478(01)00242-5 |
0.521 |
|
| 2001 |
Mahony JB, Coombes BK. Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role? Fems Microbiology Letters. 197: 1-9. PMID 11287138 DOI: 10.1111/J.1574-6968.2001.Tb10574.X |
0.619 |
|
| 2001 |
Coombes BK, Mahony JB. cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection. Infection and Immunity. 69: 1420-7. PMID 11179307 DOI: 10.1128/Iai.69.3.1420-1427.2001 |
0.617 |
|
| 2000 |
Coombes BK, Mahony JB. Nucleic acid sequence based amplification (NASBA) of Chlamydia pneumoniae major outer membrane protein (ompA) mRNA with bioluminescent detection. Combinatorial Chemistry & High Throughput Screening. 3: 315-27. PMID 10974144 |
0.518 |
|
| 2000 |
Song X, Coombes BK, Mahony JB. Quantitation of Chlamydia trachomatis 16S rRNA using NASBA amplification and a bioluminescent microtiter plate assay. Combinatorial Chemistry & High Throughput Screening. 3: 303-13. PMID 10974143 DOI: 10.2174/1386207003331571 |
0.52 |
|
| 2000 |
Mahony JB, Chong S, Coombes BK, Smieja M, Petrich A. Analytical sensitivity, reproducibility of results, and clinical performance of five PCR assays for detecting Chlamydia pneumoniae DNA in peripheral blood mononuclear cells. Journal of Clinical Microbiology. 38: 2622-7. PMID 10878053 DOI: 10.1128/Jcm.38.7.2622-2627.2000 |
0.55 |
|
| 1999 |
Coombes BK, Mahony JB. Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s). Infection and Immunity. 67: 2909-15. PMID 10338498 DOI: 10.1128/Iai.67.6.2909-2915.1999 |
0.589 |
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