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Morris F. White - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Biochemistry, Pathology
Website:
http://www.hms.harvard.edu/dms/bbs/fac/whitemorris.php
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295 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim Y, Lee JM, Han Y, Tao R, White MF, Liu R, Park SW. BRD7 improves glucose homeostasis independent of IRS proteins. The Journal of Endocrinology. 258. PMID 37578842 DOI: 10.1530/JOE-23-0119  0.477
2023 Tao R, Stöhr O, Wang C, Qiu W, Copps KD, White MF. Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance. Molecular Metabolism. 101703. PMID 36906067 DOI: 10.1016/j.molmet.2023.101703  0.358
2023 Stefan N, Schick F, Birkenfeld AL, Häring HU, White MF. The role of hepatokines in NAFLD. Cell Metabolism. 35: 236-252. PMID 36754018 DOI: 10.1016/j.cmet.2023.01.006  0.35
2022 Wagner R, Heni M, Kantartzis K, Sandforth A, Machann J, Schick F, Peter A, Fritsche L, Szendrödi J, Pfeiffer AF, Schürmann A, Blüher M, Hauner H, Seissler J, Bornstein S, ... ... White MF, et al. Lower Hepatic Fat is Associated with Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention. Diabetes. PMID 36525512 DOI: 10.2337/db22-0441  0.432
2022 Peng J, Ramatchandirin B, Wang Y, Pearah A, Namachivayam K, Wolf RM, Steele K, MohanKumar K, Yu L, Guo S, White MF, Maheshwari A, He L. The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor. The Journal of Biological Chemistry. 101621. PMID 35074429 DOI: 10.1016/j.jbc.2022.101621  0.549
2021 White M, Ronald Kahn C. Insulin action at a molecular level - 100 years of progress. Molecular Metabolism. 101304. PMID 34274528 DOI: 10.1016/j.molmet.2021.101304  0.543
2021 Tanokashira D, Wang W, Maruyama M, Kuroiwa C, White MF, Taguchi A. Irs2 deficiency alters hippocampus-associated behaviors during young adulthood. Biochemical and Biophysical Research Communications. 559: 148-154. PMID 33940386 DOI: 10.1016/j.bbrc.2021.04.101  0.385
2021 Takatani T, Shirakawa J, Shibue K, Gupta MK, Kim H, Lu S, Hu J, White MF, Kennedy RT, Kulkarni RN. Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. The Journal of Biological Chemistry. 100646. PMID 33839150 DOI: 10.1016/j.jbc.2021.100646  0.468
2021 Stöhr O, Tao R, Miao J, Copps KD, White MF. FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance. Cell Reports. 34: 108893. PMID 33761350 DOI: 10.1016/j.celrep.2021.108893  0.416
2020 Takayanagi Y, Ishizuka K, Laursen TM, Yukitake H, Yang K, Cascella NG, Ueda S, Sumitomo A, Narita Z, Horiuchi Y, Niwa M, Taguchi A, White MF, Eaton WW, Mortensen PB, et al. From population to neuron: exploring common mediators for metabolic problems and mental illnesses. Molecular Psychiatry. PMID 33173197 DOI: 10.1038/s41380-020-00939-5  0.386
2020 Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, ... White MF, et al. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. Jci Insight. 5. PMID 32213702 DOI: 10.1172/Jci.Insight.134920  0.538
2019 Zhang K, Guo X, Yan H, Wu Y, Pan Q, Shen JZ, Li X, Chen Y, Li L, Qi Y, Xu Z, Xie W, Zhang W, Threadgill D, He L, ... ... White MF, et al. Phosphorylation of forkhead protein FoxO1 at Ser253 regulates glucose homeostasis in mice. Endocrinology. PMID 30951171 DOI: 10.1210/En.2018-00853  0.572
2019 STOEHR O, TAO R, COPPS KD, WHITE MF. 282-LB: Dysregulated FGF21 Links Hepatic Insulin Resistance to Dysfunctional BAT Diabetes. 68: 282-LB. DOI: 10.2337/Db19-282-Lb  0.476
2019 TAO R, COPPS KD, WHITE MF, STOEHR O. 1835-P: Deletion of Insulin Receptor Substrate 2 in AGRP Neurons Causes Beta-Cell Dysfunction Diabetes. 68: 1835-P. DOI: 10.2337/Db19-1835-P  0.578
2018 Xi G, Shen X, Wai C, White MF, Clemmons DR. Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization. The Journal of Biological Chemistry. PMID 30578299 DOI: 10.1074/Jbc.Ra118.005398  0.508
2018 Kalvisa A, Siersbæk MS, Præstholm SM, Christensen LJL, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L. Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver. Plos Biology. 16: e2006249. PMID 30532187 DOI: 10.1371/Journal.Pbio.2006249  0.447
2018 Huang H, Lee SH, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Yang WM, Cho S, Kang MC, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, ... ... White M, et al. Rho kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. The Journal of Clinical Investigation. PMID 30226474 DOI: 10.1172/Jci63562  0.395
2018 Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia. Nature Medicine. PMID 30111893 DOI: 10.1038/S41591-018-0129-0  0.306
2018 Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Inactivating hepatic follistatin alleviates hyperglycemia. Nature Medicine. PMID 29867232 DOI: 10.1038/S41591-018-0048-0  0.54
2018 Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Ablation of insulin receptor substrates 1 and 2 suppresses-driven lung tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610318 DOI: 10.1073/Pnas.1718414115  0.529
2018 YAN H, WU Y, PAN Q, SHEN Z, ZHENG H, WHITE MF, SUN Y, GUO S. Foxo1-Ser253 Phosphorylation Regulates Glucose Homeostasis in Mice Diabetes. 67: 1883-P. DOI: 10.2337/Db18-1883-P  0.585
2018 STOEHR O, TAO R, COPPS KD, WHITE MF. Metabolic Dysfunction within Brown Adipose Tissue and Skeletal Muscle Caused by Complete Hepatic Insulin Resistance Is Reversible by FGF-21 Treatment Diabetes. 67: 1873-P. DOI: 10.2337/Db18-1873-P  0.49
2017 Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nature Communications. 8: 131. PMID 28743992 DOI: 10.1038/S41467-017-00163-W  0.53
2017 Long YC, Cheng Z, Copps KD, White MF. Correction for Long et al., "Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways". Molecular and Cellular Biology. 37. PMID 28710120 DOI: 10.1128/Mcb.00232-17  0.448
2016 Xi G, Wai C, White MF, Clemmons DR. Downregulation of Insulin Receptor Substrate-1 During Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation. The Journal of Biological Chemistry. PMID 28003360 DOI: 10.1074/Jbc.M116.758987  0.605
2016 Law NC, White MF, Hunzicker-Dunn ME. G protein-coupled receptors (GPCRs) that signal via protein kinase A (PKA) cross-talk at insulin receptor substrate 1 (IRS1) to activate the PI3K/AKT pathway. The Journal of Biological Chemistry. PMID 27856640 DOI: 10.1074/Jbc.M116.763235  0.562
2016 Lavin DP, White MF, Brazil DP. IRS proteins and diabetic complications. Diabetologia. PMID 27514532 DOI: 10.1007/S00125-016-4072-7  0.535
2016 Metz HE, Kargl J, Busch SE, Kim KH, Kurland BF, Abberbock SR, Randolph-Habecker J, Knoblaugh SE, Kolls JK, White MF, Houghton AM. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27439864 DOI: 10.1073/Pnas.1601989113  0.522
2016 Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. Jci Insight. 1. PMID 27152363 DOI: 10.1172/Jci.Insight.80749  0.486
2016 Copps KD, Hançer NJ, Qiu W, White MF. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (Irs1) Is Dispensable For Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. The Journal of Biological Chemistry. PMID 26846849 DOI: 10.1074/Jbc.M116.714915  0.641
2015 White MF. Longevity: Mapping the path to a longer life. Nature. 524: 170-1. PMID 26268188 DOI: 10.1038/524170A  0.502
2014 White MF. IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity Diabetes, Obesity and Metabolism. 16: 4-15. PMID 25200290 DOI: 10.1111/dom.12347  0.507
2014 Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, ... White MF, et al. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Molecular and Cellular Biology. 34: 3450-60. PMID 25002528 DOI: 10.1128/Mcb.00426-14  0.446
2014 Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, ... White MF, et al. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Reports. 7: 1227-38. PMID 24813896 DOI: 10.1016/J.Celrep.2014.04.006  0.661
2014 Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. The Journal of Biological Chemistry. 289: 12467-84. PMID 24652289 DOI: 10.1074/Jbc.M114.554162  0.571
2014 Sadagurski M, Dong XC, Myers MG, White MF. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Molecular Metabolism. 3: 55-63. PMID 24567904 DOI: 10.1016/J.Molmet.2013.10.004  0.485
2014 Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance. Biochemical and Biophysical Research Communications. 443: 689-93. PMID 24333417 DOI: 10.1016/J.Bbrc.2013.12.023  0.643
2013 Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, ... ... White MF, et al. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. The Journal of Clinical Investigation. 123: 5319-33. PMID 24177427 DOI: 10.1172/Jci71171  0.556
2013 Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM, Guo S. Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes. 62: 3887-900. PMID 24159000 DOI: 10.2337/Db13-0095  0.522
2013 Tao R, Xiong X, Harris RA, White MF, Dong XC. Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. Plos One. 8: e71997. PMID 23940800 DOI: 10.1371/Journal.Pone.0071997  0.492
2013 Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Science Signaling. 6: ra64. PMID 23901139 DOI: 10.1126/Scisignal.2004111  0.585
2013 Rhodes CJ, White MF, Leahy JL, Kahn SE. Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes. 62: 2157-63. PMID 23801714 DOI: 10.2337/Db13-0246  0.555
2013 Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Molecular and Cellular Biology. 33: 3227-41. PMID 23775122 DOI: 10.1128/Mcb.00506-13  0.555
2013 Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR. Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. The Journal of Biological Chemistry. 288: 23807-13. PMID 23749991 DOI: 10.1074/Jbc.M112.436279  0.633
2013 Hookham MB, O'Donovan HC, Church RH, Mercier-Zuber A, Luzi L, Curran SP, Carew RM, Droguett A, Mezzano S, Schubert M, White MF, Crean JK, Brazil DP. Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. The Febs Journal. 280: 3232-43. PMID 23617393 DOI: 10.1111/Febs.12305  0.501
2013 Jain S, De Azua IR, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer Gq-coupled receptor improves β cell function Journal of Clinical Investigation. 123: 1750-1762. PMID 23478411 DOI: 10.1172/Jci66432  0.343
2013 Sadagurski M, White MF. Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinology and Metabolism Clinics of North America. 42: 127-48. PMID 23391244 DOI: 10.1016/J.Ecl.2012.11.008  0.567
2012 Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Diabetologia. 55: 2565-2582. PMID 22869320 DOI: 10.1007/S00125-012-2644-8  0.653
2012 Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 61: 2134-45. PMID 22688336 DOI: 10.2337/Db11-1763  0.359
2012 Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 61: 2269-79. PMID 22688333 DOI: 10.2337/Db11-1462  0.606
2012 Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG, White MF. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metabolism. 15: 703-12. PMID 22560222 DOI: 10.1016/J.Cmet.2012.04.011  0.447
2012 Cheng Z, White MF. kNOXing on the door of selective insulin resistance. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1063-5. PMID 22517360 DOI: 10.1161/Atvbaha.112.246868  0.647
2012 Cheng Z, White MF. The AKTion in non-canonical insulin signaling. Nature Medicine. 18: 351-3. PMID 22395698 DOI: 10.1038/Nm.2694  0.611
2012 Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K) Journal of Biological Chemistry. 287: 4518-4530. PMID 22158866 DOI: 10.1074/Jbc.M111.286591  0.614
2012 Martín ED, Sánchez-Perez A, Trejo JL, Martin-Aldana JA, Cano Jaimez M, Pons S, Acosta Umanzor C, Menes L, White MF, Burks DJ. IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cerebral Cortex (New York, N.Y. : 1991). 22: 1717-27. PMID 21955917 DOI: 10.1093/Cercor/Bhr216  0.477
2011 Sadagurski M, Cheng Z, Rozzo A, Palazzolo I, Kelley GR, Dong X, Krainc D, White MF. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. The Journal of Clinical Investigation. 121: 4070-81. PMID 21926467 DOI: 10.1172/Jci46305  0.304
2011 Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nature Medicine. 17: 356-65. PMID 21317886 DOI: 10.1038/Nm.2293  0.547
2011 Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Molecular and Cellular Biology. 31: 430-41. PMID 21135130 DOI: 10.1128/Mcb.00983-10  0.533
2011 Wei D, Tao R, Zhang Y, White MF, Dong XC. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. American Journal of Physiology. Endocrinology and Metabolism. 300: E312-20. PMID 21081708 DOI: 10.1152/Ajpendo.00524.2010  0.402
2011 Cheng Z, White MF. Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxidants & Redox Signaling. 14: 649-61. PMID 20615072 DOI: 10.1089/Ars.2010.3370  0.46
2011 Wang Z, Cheng Z, Cristofaro V, Li J, Gong E, Strle K, Sullivan M, Adam R, White M, Olumi A. 1375 BLADDER DYSFUNCTION ASSOCIATED WITH TYPE 2 DIABETES IS IMPROVED BY INHIBITION OF INFLAMMATORY AND APOPTOTIC MEDIATORS Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.1199  0.374
2010 Cheng Z, Tseng Y, White MF. Insulin signaling meets mitochondria in metabolism. Trends in Endocrinology and Metabolism: Tem. 21: 589-98. PMID 20638297 DOI: 10.1016/J.Tem.2010.06.005  0.547
2010 Zaret KS, White MF. Diabetes forum: Extreme makeover of pancreatic alpha-cells. Nature. 464: 1132-3. PMID 20414295 DOI: 10.1038/4641132A  0.368
2010 Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metabolism. 11: 84-92. PMID 20074531 DOI: 10.1016/J.Cmet.2009.11.003  0.603
2010 Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 151: 741-7. PMID 20032056 DOI: 10.1210/En.2009-0705  0.754
2010 Cheng Z, White MF. Foxo1 in hepatic lipid metabolism. Cell Cycle (Georgetown, Tex.). 9: 219-20. PMID 20023377 DOI: 10.4161/Cc.9.2.10567  0.319
2010 Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF. Human IL6 enhances leptin action in mice. Diabetologia. 53: 525-35. PMID 19902173 DOI: 10.1007/S00125-009-1580-8  0.367
2010 Barbieri M, Rizzo MR, Papa M, Boccardi V, Esposito A, White MF, Paolisso G. The IRS2 Gly1057Asp variant is associated with human longevity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 282-6. PMID 19887537 DOI: 10.1093/Gerona/Glp154  0.575
2010 White MF. IRS-Protein scaffolds and insulin/igf action in central and peripheral tissues Handbook of Cell Signaling, 2/E. 3: 2873-2883. DOI: 10.1016/B978-0-12-374145-5.00331-4  0.558
2009 Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine. 15: 1307-11. PMID 19838201 DOI: 10.1038/Nm.2049  0.524
2009 Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Molecular and Cellular Biology. 29: 5070-83. PMID 19596788 DOI: 10.1128/Mcb.00138-09  0.446
2009 Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF. Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology. 150: 4531-40. PMID 19574401 DOI: 10.1210/En.2009-0395  0.41
2009 White MF. Metformin and insulin meet in a most atypical way. Cell Metabolism. 9: 485-7. PMID 19490902 DOI: 10.1016/J.Cmet.2009.05.007  0.559
2009 Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB. Targeted disruption of ROCK1 causes insulin resistance in vivo. The Journal of Biological Chemistry. 284: 11776-80. PMID 19276091 DOI: 10.1074/Jbc.C900014200  0.644
2009 Copps KD, White MF. Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes. 58: 26-7. PMID 19114728 DOI: 10.2337/Db08-1517  0.487
2009 Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R. Irs2 inactivation suppresses tumor progression in Pten+/- mice. The American Journal of Pathology. 174: 276-86. PMID 19095950 DOI: 10.2353/Ajpath.2009.080086  0.381
2009 Baskin DG, White MF, Schwartz MW. P-2: Insulin and food intake increase neuronal phosphotyrosine levels in the arcuate nucleus of the rat hypothalamus Experimental and Clinical Endocrinology & Diabetes. 104: 66-67. DOI: 10.1055/S-0029-1211545  0.391
2009 Peraldi P, Hotamisligil GS, Buurman WA, White M, Spiegelman BM. O-47: Mechanisms of TNF-α induced insulin resistance Experimental and Clinical Endocrinology & Diabetes. 104: 59-59. DOI: 10.1055/s-0029-1211538  0.324
2009 Harada S, Smith RM, Smith JA, White MF, Jarett L. O-43: Multiple pathways for insulin-induced egr-1 expression Experimental and Clinical Endocrinology & Diabetes. 104: 53-54. DOI: 10.1055/S-0029-1211534  0.495
2009 Ursø B, Christoffersen CT, Ouwens M, Vlahos C, Tornqvist H, White M, Naor D, Meyts PD. O-42: Mitogenic signalling by insulin in a T-cell lymphoma, the LB cell line, devoid of IGF-I receptors: evidence for the lack of involvement of the RAS-MAP kinase pathway and for a possibly novel IRS-like molecule Experimental and Clinical Endocrinology & Diabetes. 104: 52-53. DOI: 10.1055/S-0029-1211533  0.519
2009 Sawka-Verhelle D, Tartare-Deckert S, White MF, Obberghen EV. O-27: IRS-2 binds to the insulin receptor through its PTB domain and through a newly identified domain comprising amino acids 591 to 786 Experimental and Clinical Endocrinology & Diabetes. 104: 36-37. DOI: 10.1055/S-0029-1211518  0.458
2009 Sun XJ, Wang L, Zhang Y, Yenush L, Glasheen E, Myers MG, Lane WS, Pierce JH, White MF. O-25: Purification and cloning of IRS-2 reveals the molecular bases of IRS-proteins in insulin and cytokine signaling Experimental and Clinical Endocrinology & Diabetes. 104: 34-35. DOI: 10.1055/S-0029-1211516  0.527
2008 Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes. 57: 2644-51. PMID 18633112 DOI: 10.2337/Db06-0454  0.558
2008 Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metabolism. 8: 65-76. PMID 18590693 DOI: 10.1016/J.Cmet.2008.06.006  0.542
2008 Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. Plos Biology. 6: e37. PMID 18288891 DOI: 10.1371/Journal.Pbio.0060037  0.481
2008 Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature Structural & Molecular Biology. 15: 251-8. PMID 18278056 DOI: 10.1038/Nsmb.1388  0.619
2008 Li D, Yin X, Zmuda EJ, Wolford CC, Dong X, White MF, Hai T. The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes. 57: 635-44. PMID 18057093 DOI: 10.2337/Db07-0717  0.373
2008 Taguchi A, White MF. Insulin-like signaling, nutrient homeostasis, and life span. Annual Review of Physiology. 70: 191-212. PMID 17988211 DOI: 10.1146/Annurev.Physiol.70.113006.100533  0.57
2008 Taguchi A, White MF. Response to comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis" Science. 320. DOI: 10.1126/Science.1152620  0.546
2007 Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (New York, N.Y.). 317: 369-72. PMID 17641201 DOI: 10.1126/Science.1142179  0.483
2007 Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Molecular Endocrinology (Baltimore, Md.). 21: 2294-302. PMID 17579213 DOI: 10.1210/Me.2007-0159  0.759
2007 Sadagurski M, Nofech-Mozes S, Weingarten G, White MF, Kadowaki T, Wertheimer E. Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. Journal of Cellular Physiology. 213: 519-27. PMID 17508357 DOI: 10.1002/Jcp.21131  0.419
2007 Kim JJ, Kido Y, Scherer PE, White MF, Accili D. Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. American Journal of Physiology. Endocrinology and Metabolism. 292: E1694-701. PMID 17299086 DOI: 10.1152/Ajpendo.00430.2006  0.487
2007 Gonzalez-Navarro H, Vila-Caballer M, Pastor MF, Vinue A, White MF, Burks D, Andres V. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Frontiers in Bioscience : a Journal and Virtual Library. 12: 2291-8. PMID 17127239 DOI: 10.2741/2231  0.449
2007 White M. The Molecular Basis Of Insulin Action The Biomedical & Life Sciences Collection. 82-118. DOI: 10.1201/B12794-13  0.558
2006 Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM. Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Molecular and Cellular Biology. 26: 9338-51. PMID 17030605 DOI: 10.1128/Mcb.01032-06  0.456
2006 White MF. Regulating insulin signaling and beta-cell function through IRS proteins. Canadian Journal of Physiology and Pharmacology. 84: 725-37. PMID 16998536 DOI: 10.1139/y06-008  0.438
2006 Guo S, Dunn SL, White MF. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular Endocrinology (Baltimore, Md.). 20: 3389-99. PMID 16916938 DOI: 10.1210/Me.2006-0092  0.668
2006 Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. The Journal of Clinical Investigation. 116: 101-14. PMID 16374520 DOI: 10.1172/Jci25735  0.541
2006 Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. The Journal of Biological Chemistry. 281: 2649-53. PMID 16326700 DOI: 10.1074/Jbc.M512373200  0.451
2006 Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. The Journal of Biological Chemistry. 281: 1159-68. PMID 16272563 DOI: 10.1074/Jbc.M508307200  0.715
2005 Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. The Journal of Clinical Investigation. 115: 3587-93. PMID 16284649 DOI: 10.1172/Jci25151  0.547
2005 Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. The Journal of Biological Chemistry. 280: 39388-93. PMID 16170201 DOI: 10.1074/Jbc.M504155200  0.587
2005 Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG. Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation. Life Sciences. 77: 3068-77. PMID 15982669 DOI: 10.1016/J.Lfs.2005.02.034  0.534
2005 Clough MH, Schneider DJ, Sobel BE, White MF, Wadsworth MP, Taatjes DJ. Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E Journal of Histochemistry and Cytochemistry. 53: 603-610. PMID 15872053 DOI: 10.1369/Jhc.4A6590.2005  0.509
2005 Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Molecular and Cellular Biology. 25: 3752-62. PMID 15831479 DOI: 10.1128/Mcb.25.9.3752-3762.2005  0.331
2005 Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. American Journal of Physiology. Endocrinology and Metabolism. 289: E337-46. PMID 15827066 DOI: 10.1152/Ajpendo.00032.2004  0.603
2005 Sadagurski M, Weingarten G, Rhodes CJ, White MF, Wertheimer E. Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. The Journal of Biological Chemistry. 280: 14536-44. PMID 15705592 DOI: 10.1074/Jbc.M410227200  0.63
2005 Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1240-8. PMID 15689562 DOI: 10.1523/Jneurosci.3664-04.2005  0.534
2005 Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nature Medicine. 11: 175-82. PMID 15685168 DOI: 10.1038/Nm1187  0.443
2004 Fisher TL, White MF. Signaling pathways: the benefits of good communication. Current Biology : Cb. 14: R1005-7. PMID 15589136 DOI: 10.1016/J.Cub.2004.11.024  0.722
2004 Valverde AM, Fabregat I, Burks DJ, White MF, Benito M. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (Baltimore, Md.). 40: 1285-94. PMID 15565601 DOI: 10.1002/Hep.20485  0.6
2004 Nagle JA, Ma Z, Byrne MA, White MF, Shaw LM. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Molecular and Cellular Biology. 24: 9726-35. PMID 15509777 DOI: 10.1128/Mcb.24.22.9726-9735.2004  0.41
2004 Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. The Journal of Clinical Investigation. 114: 908-16. PMID 15467829 DOI: 10.1172/Jci22217  0.467
2004 Carter EA, Burks D, Fischman AJ, White M, Tompkins RG. Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. International Journal of Molecular Medicine. 14: 653-8. PMID 15375597  0.428
2004 Duan C, Yang H, White MF, Rui L. Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Molecular and Cellular Biology. 24: 7435-43. PMID 15314154 DOI: 10.1128/Mcb.24.17.7435-7443.2004  0.652
2004 Lee YH, White MF. Insulin receptor substrate proteins and diabetes. Archives of Pharmacal Research. 27: 361-70. PMID 15180298 DOI: 10.1007/Bf02980074  0.662
2004 Carlson CJ, White MF, Rondinone CM. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochemical and Biophysical Research Communications. 316: 533-9. PMID 15020250 DOI: 10.1016/J.Bbrc.2004.02.082  0.586
2004 Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. American Journal of Physiology. Cell Physiology. 287: C200-8. PMID 15013949 DOI: 10.1152/Ajpcell.00415.2003  0.362
2004 Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 53: 61-6. PMID 14693698 DOI: 10.2337/Diabetes.53.1.61  0.609
2004 Giraud J, Leshan R, Lee YH, White MF. Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. The Journal of Biological Chemistry. 279: 3447-54. PMID 14623899 DOI: 10.1074/Jbc.M308631200  0.788
2004 Neid M, Datta K, Stephan S, Khanna I, Pal S, Shaw L, White M, Mukhopadhyay D. Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells Journal of Biological Chemistry. 279: 3941-3948. PMID 14604996 DOI: 10.1074/Jbc.M303975200  0.482
2004 Carter EA, Burks D, Fischman AJ, White M, Tompkins RG. Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. International Journal of Molecular Medicine. 14: 653-658. DOI: 10.3892/Ijmm.14.4.653  0.521
2003 White MF. Insulin signaling in health and disease. Science (New York, N.Y.). 302: 1710-1. PMID 14657487 DOI: 10.1126/Science.1092952  0.582
2003 Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. The Journal of Clinical Investigation. 112: 1521-32. PMID 14617753 DOI: 10.1172/Jci18581  0.694
2003 Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes. 52: 2239-48. PMID 12941762 DOI: 10.2337/Diabetes.52.9.2239  0.784
2003 Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7084-92. PMID 12904469 DOI: 10.1523/Jneurosci.23-18-07084.2003  0.622
2003 Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes & Development. 17: 1575-80. PMID 12842910 DOI: 10.1101/Gad.1097103  0.512
2003 Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M. Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. Febs Letters. 536: 161-6. PMID 12586357 DOI: 10.1016/S0014-5793(03)00049-8  0.63
2003 Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. The Journal of Biological Chemistry. 278: 2896-902. PMID 12417588 DOI: 10.1074/Jbc.M208359200  0.783
2003 White MF. IRS-Protein Scaffolds and Insulin/IGF Action Handbook of Cell Signaling. 1: 409-419. DOI: 10.1016/B978-012124546-7/50433-2  0.501
2002 Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. The Journal of Clinical Investigation. 110: 1839-47. PMID 12488434 DOI: 10.1172/Jci16857  0.456
2002 Chang Q, Li Y, White MF, Fletcher JA, Xiao S. Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Research. 62: 6035-8. PMID 12414625  0.419
2002 Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. The Journal of Clinical Investigation. 110: 1011-9. PMID 12370279 DOI: 10.1172/Jci15276  0.597
2002 Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 Journal of Biological Chemistry. 277: 42394-42398. PMID 12228220 DOI: 10.1074/Jbc.C200444200  0.568
2002 White MF. IRS proteins and the common path to diabetes. American Journal of Physiology. Endocrinology and Metabolism. 283: E413-22. PMID 12169433 DOI: 10.1152/Ajpendo.00514.2001  0.646
2002 Rhodes CJ, White MF. Molecular insights into insulin action and secretion European Journal of Clinical Investigation. 32: 3-13. PMID 12028370 DOI: 10.1046/J.1365-2362.32.S3.2.X  0.563
2002 Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. The Journal of Biological Chemistry. 277: 50230-6. PMID 12006582 DOI: 10.1074/Jbc.M200958200  0.588
2002 Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. The Journal of Clinical Investigation. 109: 1193-201. PMID 11994408 DOI: 10.1172/Jci14439  0.401
2002 Howlett KF, Sakamoto K, Hirshman MF, Aschenbach WG, Dow M, White MF, Goodyear LJ. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes. 51: 479-83. PMID 11812758 DOI: 10.2337/Diabetes.51.2.479  0.624
2002 Wurster AL, Withers DJ, Uchida T, White MF, Grusby MJ. Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Molecular and Cellular Biology. 22: 117-26. PMID 11739727 DOI: 10.1128/Mcb.22.1.117-126.2002  0.334
2002 Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. The Journal of Biological Chemistry. 277: 1531-7. PMID 11606564 DOI: 10.1074/Jbc.M101521200  0.842
2001 Mendez R, Welsh G, Kleijn M, Myers MG, White MF, Proud CG, Rhoads RE. Regulation of protein synthesis by insulin through IRS-1 Progress in Molecular and Subcellular Biology. 26: 49-93. PMID 11575167 DOI: 10.1007/978-3-642-56688-2_3  0.33
2001 Rui L, Fisher TL, Thomas J, White MF. Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. The Journal of Biological Chemistry. 276: 40362-7. PMID 11546773 DOI: 10.1074/Jbc.M105332200  0.784
2001 El Mkadem SA, Lautier C, Macari F, Molinari N, Lefèbvre P, Renard E, Gris JC, Cros G, Daurès JP, Bringer J, White MF, Grigorescu F. Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome. Diabetes. 50: 2164-8. PMID 11522686 DOI: 10.2337/Diabetes.50.9.2164  0.565
2001 Burks DJ, White MF. IRS proteins and beta-cell function Diabetes. 50. PMID 11272176 DOI: 10.2337/DIABETES.50.2007.S140  0.509
2001 Valverde AM, Mur C, Pons S, Alvarez AM, White MF, Kahn CR, Benito M. Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis. Molecular and Cellular Biology. 21: 2269-80. PMID 11259577 DOI: 10.1128/Mcb.21.7.2269-2280.2001  0.665
2001 Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. The Journal of Clinical Investigation. 107: 181-9. PMID 11160134 DOI: 10.1172/Jci10934  0.771
2001 White MF, Burks DJ, Schubert M, Rui L, Brazil DP, Ye J, Flint CL, Fisher TL, Thomas J, Myers MG. IRS-2 failure causes multisystem pathophysiology Biochemical Society Transactions. 29: A58-A58. DOI: 10.1042/Bst029A058  0.553
2000 Withers DJ, White M. Perspective: The Insulin Signaling System-A Common Link in the Pathogenesis of Type 2 Diabetes. Endocrinology. 141: 1917-1921. PMID 28200913 DOI: 10.1210/Endo.141.6.7584  0.509
2000 Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature. 407: 377-82. PMID 11014193 DOI: 10.1038/35030105  0.529
2000 Previs SF, Withers DJ, Ren JM, White MF, Shulman GI. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo Journal of Biological Chemistry. 275: 38990-38994. PMID 10995761 DOI: 10.1074/Jbc.M006490200  0.495
2000 Fasshauer M, Klein J, Ueki K, Kriauciunas KM, Benito M, White MF, Kahn CR. Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. The Journal of Biological Chemistry. 275: 25494-501. PMID 10829031 DOI: 10.1074/Jbc.M004046200  0.679
2000 Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). The Journal of Biological Chemistry. 275: 9047-54. PMID 10722755 DOI: 10.1074/Jbc.275.12.9047  0.78
2000 Goldstein BJ, Bittner-Kowalczyk A, White MF, Harbeck M. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. The Journal of Biological Chemistry. 275: 4283-9. PMID 10660596 DOI: 10.1074/jbc.275.6.4283  0.513
2000 Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2 Journal of Clinical Investigation. 105: 199-205. PMID 10642598 DOI: 10.1172/Jci7917  0.589
2000 Uchida T, Myers MG, White MF. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis Molecular and Cellular Biology. 20: 126-138. PMID 10594015 DOI: 10.1128/Mcb.20.1.126-138.2000  0.653
2000 Aguirre V, White MF. Dysregulation of IRS-proteins causes insulin resistance and diabetes Current Opinion in Endocrinology and Diabetes. 7: 1-7. DOI: 10.1097/00060793-200002000-00001  0.769
1999 Pitterle DM, Sperling RT, Myers MG, White MF, Blackshear PJ. Early biochemical events in insulin-stimulated fluid phase endocytosis. American Journal of Physiology. Endocrinology and Metabolism. 276: E94-E105. PMID 29590884 DOI: 10.1152/ajpendo.1999.276.1.E94  0.57
1999 Almind K, Frederiksen SK, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm CT, Berglund L, Reneland R, Lithell H, White MF, Van Obberghen E, Pedersen O. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Diabetologia. 42: 1244-9. PMID 10525667 DOI: 10.1007/S001250051299  0.6
1999 Solow BT, Harada S, Goldstein BJ, Smith JA, White MF, Jarett L. Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins. Molecular Endocrinology (Baltimore, Md.). 13: 1784-98. PMID 10517679 DOI: 10.1210/Mend.13.10.0361  0.668
1999 Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nature Genetics. 23: 32-40. PMID 10471495 DOI: 10.1038/12631  0.612
1999 Jiang ZY, Lin YW, Clemont A, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. The Journal of Clinical Investigation. 104: 447-57. PMID 10449437 DOI: 10.1172/Jci5971  0.567
1999 Higaki Y, Wojtaszewski JF, Hirshman MF, Withers DJ, Towery H, White MF, Goodyear LJ. Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle. The Journal of Biological Chemistry. 274: 20791-5. PMID 10409618 DOI: 10.1074/Jbc.274.30.20791  0.527
1999 Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48: 1270-4. PMID 10342815 DOI: 10.2337/Diabetes.48.6.1270  0.602
1999 Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG, White MF, King GL. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 48: 1120-30. PMID 10331419 DOI: 10.2337/Diabetes.48.5.1120  0.645
1999 Pitterle DM, Sperling RT, Myers MG, White MF, Blackshear PJ. Early biochemical events in insulin-stimulated fluid phase endocytosis American Journal of Physiology - Endocrinology and Metabolism. 276. PMID 9886955 DOI: 10.1152/Ajpendo.1999.276.1.E94  0.638
1999 Kalidas K, Wasson J, Glaser B, Meyer JM, Duprat LJ, White MF, Permutt MA. Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role. Diabetologia. 41: 1389-91. PMID 9833949 DOI: 10.1007/S001250051081  0.512
1999 Withers DJ, White MF. Insulin action and type 2 diabetes: Lessons from knockout mice Current Opinion in Endocrinology and Diabetes. 6: 141-145. DOI: 10.1097/00060793-199904000-00010  0.627
1999 COUSIN SP, HülGL SR, MYERS JMG, WHITE MF, REIFEL-MILLER A, RHODES CJ. Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling Biochemical Journal. 344: 649-658. DOI: 10.1042/Bj3440649  0.544
1999 COUSIN SP, HÜGL SR, MYERS, JR. MG, WHITE MF, REIFEL-MILLER A, RHODES CJ. Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling Biochemical Journal. 344: 649. DOI: 10.1042/0264-6021:3440649  0.464
1998 Kim B, Leventhal PS, White MF, Feldman EL. Differential Regulation of Insulin Receptor Substrate-2 and Mitogen-Activated Protein Kinase Tyrosine Phosphorylation by Phosphatidylinositol 3-Kinase Inhibitors in SH-SY5Y Human Neuroblastoma Cells* * This work was supported by NIH Grants R29-NS-32843 and R01-NS-36778, grants from the American Diabetes Association and Juvenile Diabetes Foundation (to E.L.F.), and a grant from the Millie Schembechler Adrenal Research Fund of the University of Michigan Comprehensive Cancer Center (to E.L.F. and P.S.L.). Endocrinology. 139: 4881-4889. PMID 28200261 DOI: 10.1210/endo.139.12.6348  0.31
1998 Delahaye L, Mothe-Satney I, Myers MG, White MF, Van Obberghen E. Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites. Endocrinology. 139: 4911-9. PMID 9832428 DOI: 10.1210/Endo.139.12.6379  0.582
1998 Kim B, Leventhal PS, White MF, Feldman EL. Differential regulation of insulin receptor substrate-2 and mitogen- activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3- kinase inhibitors in SH-SY5Y human neuroblastoma cells Endocrinology. 139: 4881-4889. PMID 9832424 DOI: 10.1210/Endo.139.12.6348  0.569
1998 Burks DJ, Wang J, Towery H, Ishibashi O, Lowe D, Riedel H, White MF. IRS pleckstrin homology domains bind to acidic motifs in proteins Journal of Biological Chemistry. 273: 31061-31067. PMID 9813005 DOI: 10.1074/Jbc.273.47.31061  0.411
1998 Yenush L, Zanella C, Uchida T, Bernal D, White MF. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Molecular and Cellular Biology. 18: 6784-94. PMID 9774692 DOI: 10.1128/Mcb.18.11.6784  0.67
1998 Myers MG, Mendez R, Shi P, Pierce JH, Rhoads R, White MF. The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. The Journal of Biological Chemistry. 273: 26908-14. PMID 9756938 DOI: 10.1074/jbc.273.41.26908  0.576
1998 Hügl SR, White MF, Rhodes CJ. Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS- 1 cells Journal of Biological Chemistry. 273: 17771-17779. PMID 9651378 DOI: 10.1074/jbc.273.28.17771  0.475
1998 Schuppin GT, Pons S, Hügl S, Aiello LP, King GL, White M, Rhodes CJ. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 47: 1074-85. PMID 9648831 DOI: 10.2337/Diabetes.47.7.1074  0.48
1998 White MF. The IRS-signalling system: A network of docking proteins that mediate insulin action Molecular and Cellular Biochemistry. 182: 3-11. PMID 9609109 DOI: 10.1023/A:1006806722619  0.671
1998 Valverde AM, Lorenzo M, Pons S, White MF, Benito M. Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes. Molecular Endocrinology (Baltimore, Md.). 12: 688-97. PMID 9605931 DOI: 10.1210/Mend.12.5.0106  0.661
1998 Bernal D, Almind K, Yenush L, Ayoub M, Zhang Y, Rosshani L, Larsson C, Pedersen O, White MF. Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians. Diabetes. 47: 976-9. PMID 9604879 DOI: 10.2337/Diabetes.47.6.976  0.477
1998 Jackson JG, White MF, Yee D. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. The Journal of Biological Chemistry. 273: 9994-10003. PMID 9545345 DOI: 10.1074/Jbc.273.16.9994  0.552
1998 Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 391: 900-4. PMID 9495343 DOI: 10.1038/36116  0.623
1998 Mothe I, Delahaye L, Filloux C, Pons S, White MF, Van Obberghen E. Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. Molecular Endocrinology (Baltimore, Md.). 11: 1911-23. PMID 9415396 DOI: 10.1210/Mend.11.13.0029  0.639
1998 White MF, Yenush L. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Current Topics in Microbiology and Immunology. 228: 179-208. PMID 9401207 DOI: 10.1007/978-3-642-80481-6_8  0.476
1997 Joyal JL, Burks DJ, Pons S, Matter WF, Vlahos CJ, White MF, Sacks DB. Calmodulin activates phosphatidylinositol 3-kinase Journal of Biological Chemistry. 272: 28183-28186. PMID 9353264 DOI: 10.1074/Jbc.272.45.28183  0.47
1997 Burks DJ, Pons S, Towery H, Smith-Hall J, Myers MG, Yenush L, White MF. Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin receptor Journal of Biological Chemistry. 272: 27716-27721. PMID 9346913 DOI: 10.1074/Jbc.272.44.27716  0.572
1997 Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, Pellegrini S, White MF, Kerr IM. Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. The Journal of Biological Chemistry. 272: 24183-90. PMID 9305869 DOI: 10.1074/Jbc.272.39.24183  0.571
1997 Mendez R, Kollmorgen G, White MF, Rhoads RE. Requirement of protein kinase Cζ for stimulation of protein synthesis by insulin Molecular and Cellular Biology. 17: 5184-5192. PMID 9271396  0.521
1997 White MF. The insulin signalling system and the IRS proteins Diabetologia. 40. PMID 9248696 DOI: 10.1007/S001250051387  0.63
1997 Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF. The 60 kDA insulin receptor substrate functions like an IRS protein (pp60(IRS3)) in adipose cells Biochemistry. 36: 8304-8310. PMID 9204876 DOI: 10.1021/bi9630974  0.556
1997 Yenush L, White MF. The IRS-signalling system during insulin and cytokine action Bioessays. 19: 491-500. PMID 9204766 DOI: 10.1002/Bies.950190608  0.59
1997 Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC. Interaction of p59fyn with interferon-activated Jak kinases. Biochemical and Biophysical Research Communications. 235: 83-8. PMID 9196040 DOI: 10.1006/Bbrc.1997.6741  0.355
1997 Sawka-Verhelle D, Baron V, Mothe I, Filloux C, White MF, Van Obberghen E. Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor. The Journal of Biological Chemistry. 272: 16414-20. PMID 9195949 DOI: 10.1074/Jbc.272.26.16414  0.606
1997 Sun XJ, Pons S, Wang LM, Zhang Y, Yenush L, Burks D, Myers MG, Glasheen E, Copeland NG, Jenkins NA, Pierce JH, White MF. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Molecular Endocrinology (Baltimore, Md.). 11: 251-62. PMID 9013772 DOI: 10.1210/Mend.11.2.9885  0.565
1997 Harada S, Smith RM, Smith JA, White MF, Jarett L. Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation. The Journal of Biological Chemistry. 271: 30222-6. PMID 8939974 DOI: 10.1074/Jbc.271.47.30222  0.668
1997 Uddin S, Fish EN, Sher D, Gardziola C, Colamonici OR, Kellum M, Pitha PM, White MF, Platanias LC. The IRS-pathway operates distinctively from the stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-α receptors Blood. 90: 2574-2582. DOI: 10.1182/Blood.V90.7.2574.2574_2574_2582  0.528
1996 Smith RM, Zhang S, White MF, Jarett L. The role of receptor kinase activity and the NPEY960 motif in insulin-accelerated receptor-mediated insulin internalization Journal of Receptor and Signal Transduction Research. 16: 339-355. PMID 8968965 DOI: 10.3109/10799899609039955  0.586
1996 Munshi HG, Burks DJ, Joyal JL, White MF, Sacks DB. Ca2+ regulates calmodulin binding to IQ motifs in IRS-1 Biochemistry. 35: 15883-15889. PMID 8961953 DOI: 10.1021/Bi962107Y  0.49
1996 Argetsinger LS, Norstedt G, Billestrup N, White MF, Carter-Su C. Growth hormone, interferon-γ, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling Journal of Biological Chemistry. 271: 29415-29421. PMID 8910607 DOI: 10.1074/Jbc.271.46.29415  0.574
1996 Velloso LA, Folli F, Sun XJ, White MF, Saad MJ, Kahn CR. Cross-talk between the insulin and angiotensin signaling systems. Proceedings of the National Academy of Sciences of the United States of America. 93: 12490-5. PMID 8901609 DOI: 10.1073/Pnas.93.22.12490  0.639
1996 Yenush L, Makati KJ, Smith-Hall J, Ishibashi O, Myers MG, White MF. The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. The Journal of Biological Chemistry. 271: 24300-6. PMID 8798677 DOI: 10.1074/Jbc.271.39.24300  0.589
1996 Myers MG, Zhang Y, Aldaz GA, Grammer T, Glasheen EM, Yenush L, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Molecular and Cellular Biology. 16: 4147-55. PMID 8754813 DOI: 10.1128/Mcb.16.8.4147  0.652
1996 Myers MG, White MF. Insulin signal transduction and the IRS proteins Annual Review of Pharmacology and Toxicology. 36: 615-658. PMID 8725404 DOI: 10.1146/Annurev.Pa.36.040196.003151  0.614
1996 Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. The Journal of Biological Chemistry. 271: 13018-22. PMID 8662983 DOI: 10.1074/Jbc.271.22.13018  0.573
1996 White MF. The IRS-signalling system in insulin and cytokine action Philosophical Transactions of the Royal Society B: Biological Sciences. 351: 181-189. PMID 8650265 DOI: 10.1098/rstb.1996.0015  0.408
1996 Mendez R, Myers MG, White MF, Rhoads RE. Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase Molecular and Cellular Biology. 16: 2857-2864. PMID 8649395  0.541
1996 Sun XJ, Pons S, Asano T, Myers MG, Glasheen E, White MF. The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. The Journal of Biological Chemistry. 271: 10583-7. PMID 8631859 DOI: 10.1074/Jbc.271.18.10583  0.638
1996 Yenush L, Fernandez R, Myers MG, Grammer TC, Sun XJ, Blenis J, Pierce JH, Schlessinger J, White MF. The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Molecular and Cellular Biology. 16: 2509-17. PMID 8628319 DOI: 10.1128/Mcb.16.5.2509  0.672
1996 Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. The Journal of Biological Chemistry. 271: 5980-3. PMID 8626379 DOI: 10.1074/Jbc.271.11.5980  0.602
1996 Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (New York, N.Y.). 271: 665-8. PMID 8571133 DOI: 10.1126/Science.271.5249.665  0.571
1996 Platanias LC, Uddin S, Yetter A, Sun XJ, White MF. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. The Journal of Biological Chemistry. 271: 278-82. PMID 8550573 DOI: 10.1074/Jbc.271.1.278  0.523
1995 Rordorf-Nikolic T, Van Horn DJ, Chen D, White MF, Backer JM. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit Journal of Biological Chemistry. 270: 3662-3666. PMID 7876105 DOI: 10.1074/Jbc.270.8.3662  0.472
1995 Argetsinger LS, Hsu GW, Myers MG, Billestrup N, White MF, Carter-Su C. Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. The Journal of Biological Chemistry. 270: 14685-92. PMID 7782332 DOI: 10.1074/Jbc.270.24.14685  0.621
1995 Myers MG, Grammer TC, Brooks J, Glasheen EM, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. The Journal of Biological Chemistry. 270: 11715-8. PMID 7744813 DOI: 10.1074/Jbc.270.20.11715  0.625
1995 Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG, Glasheen E, Lane WS, Pierce JH, White MF. Role of IRS-2 in insulin and cytokine signalling. Nature. 377: 173-7. PMID 7675087 DOI: 10.1038/377173A0  0.607
1995 Chen D, Van Horn DJ, White MF, Backer JM. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif Molecular and Cellular Biology. 15: 4711-4717. PMID 7651388 DOI: 10.1128/Mcb.15.9.4711  0.615
1995 Kotanides H, Moczygemba M, White MF, Reich NC. Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins Journal of Biological Chemistry. 270: 19481-19486. PMID 7642632 DOI: 10.1074/Jbc.270.33.19481  0.344
1995 Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC. Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. The Journal of Biological Chemistry. 270: 15938-41. PMID 7608146 DOI: 10.1074/Jbc.270.27.15938  0.639
1995 Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. The Journal of Biological Chemistry. 270: 24670-3. PMID 7559579 DOI: 10.1074/Jbc.270.42.24670  0.635
1995 Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers MG, Sun XJ, White MF. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 15: 4453-65. PMID 7542745 DOI: 10.1128/Mcb.15.8.4453  0.766
1995 Uddin S, Katzav S, White MF, Platanias LC. Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin Journal of Biological Chemistry. 270: 7712-7716. PMID 7535775 DOI: 10.1074/Jbc.270.13.7712  0.657
1995 Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ. Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. The Journal of Biological Chemistry. 270: 28527-30. PMID 7499365 DOI: 10.1074/Jbc.270.48.28527  0.44
1995 Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. The Journal of Biological Chemistry. 270: 27407-10. PMID 7499194 DOI: 10.1074/Jbc.270.46.27407  0.456
1995 Kharitonenkov A, Schnekenburger J, Chen Z, Knyazev P, Ali S, Zwick E, White M, Ullrich A. Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction Journal of Biological Chemistry. 270: 29189-29193. PMID 7493946 DOI: 10.1074/Jbc.270.49.29189  0.644
1995 Myers MG, Cheatham B, Fisher TL, Jachna BR, Kahn CR, Backer JM, White MF. Common and distinct elements in insulin and PDGF signaling. Annals of the New York Academy of Sciences. 766: 369-87. PMID 7486683 DOI: 10.1111/J.1749-6632.1995.Tb26687.X  0.775
1995 Myers MG, White MF. New frontiers in insulin receptor substrate signaling Trends in Endocrinology and Metabolism. 6: 209-215. DOI: 10.1016/1043-2760(95)00092-V  0.565
1994 Myers MG, Wang LM, Sun XJ, Zhang Y, Yenush L, Schlessinger J, Pierce JH, White MF. Role of IRS-1-GRB-2 complexes in insulin signaling. Molecular and Cellular Biology. 14: 3577-87. PMID 8196603 DOI: 10.1128/Mcb.14.6.3577  0.659
1994 White MF. The IRS-1 signaling system Current Opinion in Genetics and Development. 4: 47-54. PMID 8193539 DOI: 10.1016/0959-437X(94)90090-6  0.597
1994 Keegan AD, Nelms K, White M, Wang LM, Pierce JH, Paul WE. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell. 76: 811-20. PMID 8124718 DOI: 10.1016/0092-8674(94)90356-5  0.507
1994 Myers MG, Sun XJ, White MF. The IRS-1 signaling system. Trends in Biochemical Sciences. 19: 289-93. PMID 8048169 DOI: 10.1016/0968-0004(94)90007-8  0.648
1994 Feener EP, Shiba T, Hu KQ, Wilden PA, White MF, King GL. Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. The Biochemical Journal. 43-50. PMID 7945263 DOI: 10.1042/Bj3030043  0.531
1994 Baskin DG, Schwartz MW, Sipols AJ, D'Alessio DA, Goldstein BJ, White MF. Insulin receptor substrate-1 (IRS-1) expression in rat brain. Endocrinology. 134: 1952-5. PMID 7511094 DOI: 10.1210/Endo.134.4.7511094  0.587
1994 Sun XJ, Crimmins DL, Myers MG, Miralpeix M, White MF. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Molecular and Cellular Biology. 13: 7418-28. PMID 7504175 DOI: 10.1128/Mcb.13.12.7418  0.649
1993 Araki E, Sun XJ, Haag BL, Chuang LM, Zhang Y, Yang-Feng TL, White MF, Kahn CR. Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. Diabetes. 42: 1041-54. PMID 8513971 DOI: 10.2337/diab.42.7.1041  0.439
1993 Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653  0.613
1993 Myers MG, White MF. The new elements of insulin signaling: Insulin receptor substrate-1 and proteins with SH2 domains Diabetes. 42: 643-650. PMID 8387037 DOI: 10.2337/Diab.42.5.643  0.648
1993 Myers MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM, White MF. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase Endocrinology. 132: 1421-1430. PMID 8384986 DOI: 10.1210/Endo.132.4.8384986  0.651
1993 Wang LM, Myers MG, Sun XJ, Aaronson SA, White M, Pierce JH. IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science (New York, N.Y.). 261: 1591-4. PMID 8372354 DOI: 10.1126/Science.8372354  0.543
1993 Lee CH, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG, White MF, Schlessinger J, Skolnik EY. Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 11713-7. PMID 8265614 DOI: 10.1073/Pnas.90.24.11713  0.629
1993 Chuang LM, Myers MG, Seidner GA, Birnbaum MJ, White MF, Kahn CR. Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 90: 5172-5. PMID 7685118 DOI: 10.1073/Pnas.90.11.5172  0.668
1993 Wang LM, Keegan AD, Li W, Lienhard GE, Pacini S, Gutkind JS, Myers MG, Sun XJ, White MF, Aaronson SA, Paul WE, Pierce JH. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 90: 4032-4036. PMID 7683417 DOI: 10.1073/Pnas.90.9.4032  0.595
1993 Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Progress in Hormone Research. 48: 291-339. PMID 7680139 DOI: 10.1016/B978-0-12-571148-7.50015-4  0.627
1993 Felder S, Zhou M, Hu P, Ureña J, Ullrich A, Chaudhuri M, White M, Shoelson SE, Schlessinger J. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Molecular and Cellular Biology. 13: 1449-55. PMID 7680095 DOI: 10.1128/Mcb.13.3.1449  0.395
1993 Baskin DG, Sipols AJ, Schwartz MW, White MF. Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine. Regulatory Peptides. 48: 257-66. PMID 7505468 DOI: 10.1016/0167-0115(93)90355-C  0.6
1992 Müller-Wieland D, White MF, Behnke B, Gebhardt A, Neumann S, Krone W, Kahn CR. Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase. Biochemical and Biophysical Research Communications. 181: 1479-85. PMID 1722405 DOI: 10.1016/0006-291X(91)92106-T  0.669
1992 Alexander-Bridges M, Buggs C, Giere L, Denaro M, Kahn B, White M, Sukhatme V, Nasrin N. Models of insulin action on metabolic and growth response genes. Molecular and Cellular Biochemistry. 109: 99-105. PMID 1625685 DOI: 10.1007/Bf00229762  0.561
1992 Backer JM, Shoelson SE, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. The Journal of Cell Biology. 118: 831-9. PMID 1500426 DOI: 10.1083/Jcb.118.4.831  0.577
1992 Miralpeix M, Sun XJ, Backer JM, Myers MG, Araki E, White MF. Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells Biochemistry. 31: 9031-9039. PMID 1382584 DOI: 10.1021/Bi00152A046  0.644
1992 Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America. 89: 10350-4. PMID 1332046 DOI: 10.1073/Pnas.89.21.10350  0.544
1992 Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR. Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. The Journal of Clinical Investigation. 90: 1839-49. PMID 1331176 DOI: 10.1172/Jci116060  0.628
1992 Shoelson SE, Chatterjee S, Chaudhuri M, White MF. YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proceedings of the National Academy of Sciences of the United States of America. 89: 2027-31. PMID 1312712 DOI: 10.1073/Pnas.89.6.2027  0.595
1991 Okamoto M, Karasik A, White MF, Kahn CR. Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes Diabetes. 40: 66-72. PMID 1849850 DOI: 10.2337/Diab.40.1.66  0.649
1991 White MF. Structure and function of tyrosine kinase receptors Journal of Bioenergetics and Biomembranes. 23: 63-82. PMID 1849136 DOI: 10.1007/Bf00768839  0.474
1991 Backer JM, Shoelson SE, Haring E, White MF. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region. The Journal of Cell Biology. 115: 1535-45. PMID 1757462 DOI: 10.1083/Jcb.115.6.1535  0.627
1991 White MF, Backer JM. Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor Methods in Enzymology. 201: 65-79. PMID 1719349 DOI: 10.1016/0076-6879(91)01009-Q  0.648
1991 Segatto O, Lonardo F, Wexler D, Fazioli F, Pierce JH, Bottaro DP, White MF, Di Fiore PP. The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. Molecular and Cellular Biology. 11: 3191-202. PMID 1674818 DOI: 10.1128/Mcb.11.6.3191  0.612
1991 Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB. Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Molecular Endocrinology (Baltimore, Md.). 5: 769-77. PMID 1656240 DOI: 10.1210/Mend-5-6-769  0.643
1991 Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Nature. 352: 73-76. PMID 1648180 DOI: 10.1038/352073A0  0.678
1990 Okamoto M, Karasik A, White MF, Kahn CR. Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes Biochemistry®. 29: 9489-9494. PMID 2248961 DOI: 10.1021/bi00492a023  0.352
1990 Wilden PA, Backer JM, Kahn CR, Cahill DA, Schroeder GJ, White MF. The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth Proceedings of the National Academy of Sciences of the United States of America. 87: 3358-3362. PMID 2159147 DOI: 10.1073/Pnas.87.9.3358  0.672
1990 Kruszynska YT, Halban PA, Kahn CR, White MF. Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats Diabetologia. 33: 77-83. PMID 2158467 DOI: 10.1007/Bf00401044  0.613
1990 Ruderman NB, Kapeller R, White MF, Cantley LC. Activation of phosphatidylinositol 3-kinase by insulin Proceedings of the National Academy of Sciences of the United States of America. 87: 1411-1415. PMID 2154747 DOI: 10.1073/Pnas.87.4.1411  0.643
1989 White MF, Kahn CR. Cascade of autophosphorylation in the beta-subunit of the insulin receptor Journal of Cellular Biochemistry. 39: 429-441. PMID 2722971 DOI: 10.1002/Jcb.240390409  0.549
1989 Beguinot F, Kahn CR, Moses AC, White MF, Smith RJ. Differentiation-dependent phosphorylation of a 175,000 molecular weight protein in response to insulin and insulin-like growth factor-I in L6 skeletal muscle cells. Endocrinology. 125: 1599-605. PMID 2667964 DOI: 10.1210/endo-125-3-1599  0.582
1989 Cigarroa FG, Coughlin JP, Donahoe PK, White MF, Uitvlugt N, MacLaughlin DT. Recombinant human müllerian inhibiting substance inhibits epidermal growth factor receptor tyrosine kinase. Growth Factors (Chur, Switzerland). 1: 179-91. PMID 2560399 DOI: 10.3109/08977198909029127  0.387
1989 Magré J, Grigorescu F, Reynet C, Caron M, Capony JP, White MF, Picard J, Mirouze J, Capeau J. Tyrosine-kinase defect of the insulin receptor in cultured fibroblasts from patients with lipoatropic diabetes. The Journal of Clinical Endocrinology and Metabolism. 69: 142-50. PMID 2543688 DOI: 10.1210/Jcem-69-1-142  0.627
1989 Shymko RM, Gonzales NS, Backer JM, White MF, Meyts PD. Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: Application to the Tyr → Phe 960 insulin receptor mutant Biochemical and Biophysical Research Communications. 164: 191-198. PMID 2508634 DOI: 10.1016/0006-291X(89)91701-4  0.58
1989 Backer JM, Kahn CR, White MF. Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: Studies in 2,4-dinitrophenol-treated cells Proceedings of the National Academy of Sciences of the United States of America. 86: 3209-3213. PMID 2470095 DOI: 10.1073/Pnas.86.9.3209  0.62
1989 Hofmann C, White MF, Whittaker J. Human insulin receptors expressed in insulin-insensitive mouse fibroblasts couple with extant cellular effector system to confer insulin sensitivity and responsiveness Endocrinology. 124: 257-264. PMID 2462489 DOI: 10.1210/Endo-124-1-257  0.63
1988 Kahn CR, White MF. The insulin receptor and the molecular mechanism of insulin action Journal of Clinical Investigation. 82: 1151-1156. PMID 3049671 DOI: 10.1172/JCI113711  0.524
1988 White MF, Livingston JN, Backer JM, Lauris V, Dull TJ, Ullrich A, Kahn CR. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity Cell. 54: 641-649. PMID 2842060 DOI: 10.1016/S0092-8674(88)80008-4  0.658
1988 Beguinot F, Smith RJ, Kahn CR, Maron R, Moses AC, White MF. Phosphorylation of insulin-like growth factor I receptor by insulin receptor tyrosine kinase in intact cultured skeletal muscle cells. Biochemistry. 27: 3222-8. PMID 2839227 DOI: 10.1021/Bi00409A015  0.62
1988 Okamoto M, Kahn CR, Maron R, White MF. Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats American Journal of Physiology - Endocrinology and Metabolism. 254. PMID 2833110 DOI: 10.1152/Ajpendo.1988.254.4.E429  0.556
1988 Morrison DK, Browning PJ, White MF, Roberts TM. Tyrosine phosphorylations in vivo associated with v-fms transformation Molecular and Cellular Biology. 8: 176-185. PMID 2447483 DOI: 10.1128/Mcb.8.1.176  0.348
1987 Ballotti R, Kowalski A, White MF, Le Marchand-Brustel Y, Van Obberghen E. Insulin stimulates tyrosine phosphorylation of its receptor beta-subunit in intact rat hepatocytes. The Biochemical Journal. 241: 99-104. PMID 3551929 DOI: 10.1042/bj2410099  0.55
1987 Häring HU, White MF, Machicao F, Ermel B, Schleicher E, Obermaier B. Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 113-7. PMID 3540953 DOI: 10.1073/Pnas.84.1.113  0.618
1987 Machicao F, Haring H, White MF. An M(r) 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta Biochemical Journal. 243: 797-801. PMID 2821993 DOI: 10.1042/Bj2430797  0.64
1987 Carpentier JL, White MF, Orci L, Kahn RC. Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells Journal of Cell Biology. 105: 2751-2762. PMID 2447100 DOI: 10.1083/jcb.105.6.2751  0.318
1987 Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity Cell. 50: 1021-1029. PMID 2441878 DOI: 10.1016/0092-8674(87)90168-1  0.415
1987 Sale EM, White MF, Kahn CR. Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase Journal of Cellular Biochemistry. 33: 15-26. PMID 2434517 DOI: 10.1002/Jcb.240330103  0.64
1986 Okamoto M, White MF, Maron R, Kahn CR. Autophosphorylation and kinase activity of insulin receptor in diabetic rats American Journal of Physiology - Endocrinology and Metabolism. 251. PMID 2430467 DOI: 10.1152/Ajpendo.1986.251.5.E542  0.619
1986 White MF, Kahn CR. 7 The Insulin Receptor and Tyrosine Phosphorylation Enzymes. 17: 247-310. DOI: 10.1016/S1874-6047(08)60432-1  0.656
1985 Kasuga M, White MF, Kahn CR. Phosphorylation of the insulin receptor in cultured hepatoma cells and a solubilized system Methods in Enzymology. 609-621. PMID 3990573 DOI: 10.1016/0076-6879(85)09118-2  0.623
1985 Haring HU, White MF, Kahn CR, Ahmad Z, DePaoli-Roach AA, Roach PJ. Interaction of the insulin receptor kinase with serine/threonine kinases in vitro Journal of Cellular Biochemistry. 28: 171-182. PMID 3001107 DOI: 10.1002/Jcb.240280209  0.604
1985 White MF, Maron R, Kahn CR. Insulin rapidly stimulates tyrosine phosphorylation of a M r-185,000 protein in intact cells Nature. 318: 183-186. PMID 2414672 DOI: 10.1038/318183A0  0.662
1984 Takayama S, White MF, Lauris V, Kahn CR. Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells Proceedings of the National Academy of Sciences of the United States of America. 81: 7797-7801. PMID 6393128 DOI: 10.1073/Pnas.81.24.7797  0.661
1984 Haring HU, White MF, Kahn CR, Kasuga M, Lauris V, Fleischmann R, Murray M, Pawelek J. Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line. The Journal of Cell Biology. 99: 900-8. PMID 6381509 DOI: 10.1083/Jcb.99.3.900  0.653
1984 White MF, Werth DK, Pastan I, Kahn CR. Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60(src) Journal of Cellular Biochemistry. 26: 169-179. PMID 6098589 DOI: 10.1002/Jcb.240260305  0.647
1984 Haring HU, Kasuga M, White MF, Crettaz M, Kahn CR. Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity. Biochemistry. 23: 3298-306. PMID 6087892 DOI: 10.1021/bi00309a028  0.583
1983 White MF, Christensen HN. Simultaneous regulation of amino acid influx and efflux by System A in the hepatoma cell HTC. Ouabain simulates the starvation-induced derepression of System A amino acid transport Journal of Biological Chemistry. 258: 8028-8038. PMID 6863276  0.433
1982 White MF, Christensen HN. The two-way flux of cationic amino acids across the plasma membrane of mammalian cells is largely explained by a single transport system Journal of Biological Chemistry. 257: 10069-10080. PMID 7107597  0.435
1982 White MF, Christensen HN. Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines Journal of Biological Chemistry. 257: 4450-4457. PMID 7068644  0.454
1982 White MF, Gazzola GC, Christensen HN. Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblast Journal of Biological Chemistry. 257: 4443-4449. PMID 7040384  0.432
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