| Year |
Citation |
Score |
| 2019 |
Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman JL, Ignatova Z, Sorscher EJ. Slowing ribosome velocity restores folding and function of mutant CFTR. The Journal of Clinical Investigation. PMID 31657788 DOI: 10.1172/Jci124282 |
0.305 |
|
| 2016 |
Sabusap CM, Wang W, McNicholas CM, Chung WJ, Fu L, Wen H, Mazur M, Kirk KL, Collawn JF, Hong JS, Sorscher EJ. Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases. Jci Insight. 1. PMID 27660821 DOI: 10.1172/Jci.Insight.86581 |
0.375 |
|
| 2016 |
Cho DY, Skinner D, Zhang S, Fortenberry J, Sorscher EJ, Dean NR, Woodworth BA. Cystic fibrosis transmembrane conductance regulator activation by the solvent ethanol: implications for topical drug delivery. International Forum of Allergy & Rhinology. 6: 178-84. PMID 26869199 DOI: 10.1002/Alr.21638 |
0.322 |
|
| 2015 |
Ehrhardt A, Chung WJ, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, ... Sorscher EJ, et al. Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. The Journal of Biological Chemistry. PMID 26627831 DOI: 10.1074/Jbc.M115.704809 |
0.694 |
|
| 2015 |
Rosenthal EL, Chung TK, Parker WB, Allan PW, Clemons L, Lowman D, Hong J, Hunt FR, Richman J, Conry RM, Mannion K, Carroll WR, Nabell L, Sorscher EJ. Phase I dose-escalating trial of Escherichia coli purine nucleoside phosphorylase and fludarabine gene therapy for advanced solid tumors†. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 26: 1481-7. PMID 25899782 DOI: 10.1093/Annonc/Mdv196 |
0.343 |
|
| 2015 |
Crane AM, Kramer P, Bui JH, Chung WJ, Li XS, Gonzalez-Garay ML, Hawkins F, Liao W, Mora D, Choi S, Wang J, Sun HC, Paschon DE, Guschin DY, Gregory PD, ... ... Sorscher EJ, et al. Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells. Stem Cell Reports. 4: 569-77. PMID 25772471 DOI: 10.1016/J.Stemcr.2015.02.005 |
0.401 |
|
| 2015 |
Chung TK, Rosenthal E, Parker WB, Allan P, Clemons L, Lowman D, Hong J, Hunt FR, Richman J, Conry RM, Mannion K, Carroll W, Nabell L, Sorscher EJ. First-in-human dose-escalating trial of E.coli purine nucleoside phosphorylase and fludarabine gene therapy for advanced solid tumors. Journal of Clinical Oncology. 33: 3084-3084. DOI: 10.1200/Jco.2015.33.15_Suppl.3084 |
0.359 |
|
| 2015 |
Davis BR, Crane AM, Kramer P, Bui JH, Joon Chung W, Shirley Li X, Gonzalez-Garay ML, Hawkins F, Liao W, Mora D, Wang J, Sun HC, Paschon DE, Guschin DY, Gregory PD, ... ... Sorscher EJ, et al. 185. Targeted Correction and Restored Function of CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Molecular Therapy. 23: S74. DOI: 10.1016/S1525-0016(16)33790-X |
0.415 |
|
| 2014 |
Zhang S, Skinner D, Hicks SB, Bevensee MO, Sorscher EJ, Lazrak A, Matalon S, McNicholas CM, Woodworth BA. Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance. Plos One. 9: e104090. PMID 25117505 DOI: 10.1371/Journal.Pone.0104090 |
0.347 |
|
| 2014 |
Birket SE, Chu KK, Liu L, Houser GH, Diephuis BJ, Wilsterman EJ, Dierksen G, Mazur M, Shastry S, Li Y, Watson JD, Smith AT, Schuster BS, Hanes J, Grizzle WE, ... Sorscher EJ, et al. A functional anatomic defect of the cystic fibrosis airway. American Journal of Respiratory and Critical Care Medicine. 190: 421-32. PMID 25029666 DOI: 10.1164/Rccm.201404-0670Oc |
0.34 |
|
| 2014 |
Lee S, Henderson MJ, Schiffhauer E, Despanie J, Henry K, Kang PW, Walker D, McClure ML, Wilson L, Sorscher EJ, Zeitlin PL. Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools. Molecular and Cellular Biology. 34: 2554-65. PMID 24777605 DOI: 10.1128/Mcb.01042-13 |
0.327 |
|
| 2014 |
Dean N, Ranganath NK, Jones B, Zhang S, Skinner D, Rowe SM, Sorscher EJ, Woodworth BA. Porcine nasal epithelial cultures for studies of cystic fibrosis sinusitis. International Forum of Allergy & Rhinology. 4: 565-70. PMID 24733748 DOI: 10.1002/Alr.21335 |
0.374 |
|
| 2014 |
Oren YS, McClure ML, Rowe SM, Sorscher EJ, Bester AC, Manor M, Kerem E, Rivlin J, Zahdeh F, Mann M, Geiger T, Kerem B. The unfolded protein response affects readthrough of premature termination codons. Embo Molecular Medicine. 6: 685-701. PMID 24705877 DOI: 10.1002/Emmm.201303347 |
0.312 |
|
| 2014 |
Tuggle KL, Birket SE, Cui X, Hong J, Warren J, Reid L, Chambers A, Ji D, Gamber K, Chu KK, Tearney G, Tang LP, Fortenberry JA, Du M, Cadillac JM, ... ... Sorscher EJ, et al. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. Plos One. 9: e91253. PMID 24608905 DOI: 10.1371/Journal.Pone.0091253 |
0.399 |
|
| 2014 |
McClure ML, Wen H, Fortenberry J, Hong JS, Sorscher EJ. S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment. The Biochemical Journal. 459: 417-25. PMID 24475974 DOI: 10.1042/Bj20131037 |
0.395 |
|
| 2014 |
Zhang S, Ranganath NK, Skinner D, Bedwell DM, Buckley-Lanier JA, Sorscher EJ, Woodworth BA. Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 13: 351-2. PMID 24378376 DOI: 10.1016/J.Jcf.2013.11.009 |
0.397 |
|
| 2013 |
Zhang S, Blount AC, McNicholas CM, Skinner DF, Chestnut M, Kappes JC, Sorscher EJ, Woodworth BA. Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability. Plos One. 8: e81589. PMID 24282612 DOI: 10.1371/Journal.Pone.0081589 |
0.37 |
|
| 2013 |
Kong M, Maeng P, Hong J, Szczesniak R, Sorscher E, Sullender W, Clancy JP. Respiratory syncytial virus infection disrupts monolayer integrity and function in cystic fibrosis airway cells. Viruses. 5: 2260-71. PMID 24056672 DOI: 10.3390/V5092260 |
0.346 |
|
| 2013 |
Conger BT, Zhang S, Skinner D, Hicks SB, Sorscher EJ, Rowe SM, Woodworth BA. Comparison of cystic fibrosis transmembrane conductance regulator (CFTR) and ciliary beat frequency activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures. Jama Otolaryngology-- Head & Neck Surgery. 139: 822-7. PMID 23949358 DOI: 10.1001/Jamaoto.2013.3917 |
0.387 |
|
| 2013 |
Lazrak A, Fu L, Bali V, Bartoszewski R, Rab A, Havasi V, Keiles S, Kappes J, Kumar R, Lefkowitz E, Sorscher EJ, Matalon S, Collawn JF, Bebok Z. The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4630-45. PMID 23907436 DOI: 10.1096/Fj.13-227330 |
0.334 |
|
| 2013 |
Aeffner F, Abdulrahman B, Hickman-Davis JM, Janssen PM, Amer A, Bedwell DM, Sorscher EJ, Davis IC. Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity. The Journal of Infectious Diseases. 208: 780-9. PMID 23749967 DOI: 10.1093/Infdis/Jit251 |
0.326 |
|
| 2012 |
Louie RJ, Guo J, Rodgers JW, White R, Shah N, Pagant S, Kim P, Livstone M, Dolinski K, McKinney BA, Hong J, Sorscher EJ, Bryan J, Miller EA, Hartman JL. A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Genome Medicine. 4: 103. PMID 23270647 DOI: 10.1186/Gm404 |
0.369 |
|
| 2012 |
Sloane PA, Shastry S, Wilhelm A, Courville C, Tang LP, Backer K, Levin E, Raju SV, Li Y, Mazur M, Byan-Parker S, Grizzle W, Sorscher EJ, Dransfield MT, Rowe SM. A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease. Plos One. 7: e39809. PMID 22768130 DOI: 10.1371/Journal.Pone.0039809 |
0.354 |
|
| 2012 |
Sorscher EJ, Hong JS, Allan PW, Waud WR, Parker WB. In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase. Cancer Chemotherapy and Pharmacology. 70: 321-9. PMID 22760227 DOI: 10.1007/S00280-012-1908-9 |
0.327 |
|
| 2012 |
Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, ... Sorscher E, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/Rccm.201111-2068Ws |
0.342 |
|
| 2012 |
McClure M, DeLucas LJ, Wilson L, Ray M, Rowe SM, Wu X, Dai Q, Hong JS, Sorscher EJ, Kappes JC, Barnes S. Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications. Protein Engineering, Design & Selection : Peds. 25: 7-14. PMID 22119790 DOI: 10.1093/Protein/Gzr054 |
0.35 |
|
| 2011 |
Zhang S, Smith N, Schuster D, Azbell C, Sorscher EJ, Rowe SM, Woodworth BA. Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis. American Journal of Rhinology & Allergy. 25: 307-12. PMID 22186243 DOI: 10.2500/Ajra.2011.25.3643 |
0.369 |
|
| 2011 |
Blount A, Zhang S, Chestnut M, Hixon B, Skinner D, Sorscher EJ, Woodworth BA. Transepithelial ion transport is suppressed in hypoxic sinonasal epithelium. The Laryngoscope. 121: 1929-34. PMID 22024847 DOI: 10.1002/Lary.21921 |
0.357 |
|
| 2011 |
Pyle LC, Ehrhardt A, Mitchell LH, Fan L, Ren A, Naren AP, Li Y, Clancy JP, Bolger GB, Sorscher EJ, Rowe SM. Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators. American Journal of Physiology. Lung Cellular and Molecular Physiology. 301: L587-97. PMID 21724857 DOI: 10.1152/Ajplung.00465.2010 |
0.707 |
|
| 2011 |
Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA. CFTR Folding Consortium: methods available for studies of CFTR folding and correction. Methods in Molecular Biology (Clifton, N.J.). 742: 335-53. PMID 21547742 DOI: 10.1007/978-1-61779-120-8_20 |
0.385 |
|
| 2011 |
Parker WB, Allan PW, Waud WR, Hong JS, Sorscher EJ. Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase Cancer Gene Therapy. 18: 390-398. PMID 21394111 DOI: 10.1038/Cgt.2011.4 |
0.377 |
|
| 2010 |
Azbell C, Zhang S, Skinner D, Fortenberry J, Sorscher EJ, Woodworth BA. Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 143: 397-404. PMID 20723778 DOI: 10.1016/J.Otohns.2010.05.021 |
0.333 |
|
| 2010 |
Virgin FW, Azbell C, Schuster D, Sunde J, Zhang S, Sorscher EJ, Woodworth BA. Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial cultures. The Laryngoscope. 120: 1465-9. PMID 20564721 DOI: 10.1002/Lary.20930 |
0.309 |
|
| 2010 |
Tai CK, Wang W, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, Kasahara N. Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene. Cancer Gene Therapy. 17: 614-23. PMID 20467451 DOI: 10.1038/Cgt.2010.17 |
0.36 |
|
| 2010 |
Virgin F, Zhang S, Schuster D, Azbell C, Fortenberry J, Sorscher EJ, Woodworth BA. The bioflavonoid compound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo. The Laryngoscope. 120: 1051-6. PMID 20422703 DOI: 10.1002/Lary.20871 |
0.318 |
|
| 2010 |
Rowe SM, Pyle LC, Jurkevante A, Varga K, Collawn J, Sloane PA, Woodworth B, Mazur M, Fulton J, Fan L, Li Y, Fortenberry J, Sorscher EJ, Clancy JP. DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers. Pulmonary Pharmacology & Therapeutics. 23: 268-78. PMID 20226262 DOI: 10.1016/J.Pupt.2010.02.001 |
0.712 |
|
| 2010 |
Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, ... Sorscher EJ, et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nature Chemical Biology. 6: 25-33. PMID 19966789 DOI: 10.1038/Nchembio.275 |
0.361 |
|
| 2009 |
Cormet-Boyaka E, Hong JS, Berdiev BK, Fortenberry JA, Rennolds J, Clancy JP, Benos DJ, Boyaka PN, Sorscher EJ. A truncated CFTR protein rescues endogenous DeltaF508-CFTR and corrects chloride transport in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3743-51. PMID 19620404 DOI: 10.1096/Fj.08-127878 |
0.436 |
|
| 2009 |
Guimbellot JS, Erickson SW, Mehta T, Wen H, Page GP, Sorscher EJ, Hong JS. Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis. Bmc Medical Genomics. 2: 15. PMID 19320992 DOI: 10.1186/1755-8794-2-15 |
0.69 |
|
| 2008 |
Havasi V, Keiles S, Hambuch T, Sorscher EJ, Kammesheidt A. The role of the F508C mutation in congenital bilateral absence of the vas deferens. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 10: 910-4. PMID 19092444 DOI: 10.1097/Gim.0B013E31818E594D |
0.338 |
|
| 2008 |
White AF, Mazur M, Sorscher EJ, Zinn KR, Ponnazhagan S. Genetic modification of adeno-associated viral vector type 2 capsid enhances gene transfer efficiency in polarized human airway epithelial cells. Human Gene Therapy. 19: 1407-14. PMID 18778196 DOI: 10.1089/Hum.2008.117 |
0.387 |
|
| 2008 |
Rowe SM, Jackson PL, Liu G, Hardison M, Livraghi A, Solomon GM, McQuaid DB, Noerager BD, Gaggar A, Clancy JP, O'Neal W, Sorscher EJ, Abraham E, Blalock JE. Potential role of high-mobility group box 1 in cystic fibrosis airway disease. American Journal of Respiratory and Critical Care Medicine. 178: 822-31. PMID 18658107 DOI: 10.1164/Rccm.200712-1894Oc |
0.301 |
|
| 2008 |
Guimbellot JS, Fortenberry JA, Siegal GP, Moore B, Wen H, Venglarik C, Chen YF, Oparil S, Sorscher EJ, Hong JS. Role of oxygen availability in CFTR expression and function. American Journal of Respiratory Cell and Molecular Biology. 39: 514-21. PMID 18474670 DOI: 10.1165/Rcmb.2007-0452Oc |
0.731 |
|
| 2008 |
Horváth G, Sorscher EJ. Luminal fluid tonicity regulates airway ciliary beating by altering membrane stretch and intracellular calcium. Cell Motility and the Cytoskeleton. 65: 469-75. PMID 18435452 DOI: 10.1002/Cm.20273 |
0.346 |
|
| 2008 |
Havasi V, Hurst CO, Briles TC, Yang F, Bains DG, Hassett DJ, Sorscher E. Inhibitory effects of hypertonic saline on P. aeruginosa motility. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 7: 267-9. PMID 18249160 DOI: 10.1016/J.Jcf.2007.11.009 |
0.314 |
|
| 2008 |
Varga K, Goldstein RF, Jurkuvenaite A, Chen L, Matalon S, Sorscher EJ, Bebok Z, Collawn JF. Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones. The Biochemical Journal. 410: 555-64. PMID 18052931 DOI: 10.1042/Bj20071420 |
0.361 |
|
| 2007 |
Berdiev BK, Cormet-Boyaka E, Tousson A, Qadri YJ, Oosterveld-Hut HM, Hong JS, Gonzales PA, Fuller CM, Sorscher EJ, Lukacs GL, Benos DJ. Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 282: 36481-8. PMID 17913705 DOI: 10.1074/Jbc.M708089200 |
0.324 |
|
| 2007 |
Ungerechts G, Springfeld C, Frenzke ME, Lampe J, Parker WB, Sorscher EJ, Cattaneo R. An immunocompetent murine model for oncolysis with an armed and targeted measles virus. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1991-7. PMID 17712331 DOI: 10.1038/Sj.Mt.6300291 |
0.327 |
|
| 2007 |
Rowe SM, Varga K, Rab A, Bebok Z, Byram K, Li Y, Sorscher EJ, Clancy JP. Restoration of W1282X CFTR activity by enhanced expression. American Journal of Respiratory Cell and Molecular Biology. 37: 347-56. PMID 17541014 DOI: 10.1165/Rcmb.2006-0176Oc |
0.425 |
|
| 2007 |
Bates E, Miller S, Alexander M, Mazur M, Fortenberry JA, Bebok Z, Sorscher EJ, Rowe SM. Bioelectric effects of quinine on polarized airway epithelial cells. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 6: 351-9. PMID 17329172 DOI: 10.1016/J.Jcf.2007.01.001 |
0.39 |
|
| 2006 |
Su X, Li Q, Shrestha K, Cormet-Boyaka E, Chen L, Smith PR, Sorscher EJ, Benos DJ, Matalon S, Ji HL. Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 281: 36960-8. PMID 17012229 DOI: 10.1074/Jbc.M608002200 |
0.426 |
|
| 2006 |
Du M, Keeling KM, Fan L, Liu X, Kovaçs T, Sorscher E, Bedwell DM. Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model. Journal of Molecular Medicine (Berlin, Germany). 84: 573-82. PMID 16541275 DOI: 10.1007/S00109-006-0045-5 |
0.335 |
|
| 2006 |
Hill AE, Hong JS, Wen H, Teng L, McPherson DT, McPherson SA, Levasseur DN, Sorscher EJ. Micro-RNA-like effects of complete intronic sequences. Frontiers in Bioscience : a Journal and Virtual Library. 11: 1998-2006. PMID 16368574 DOI: 10.2741/1941 |
0.332 |
|
| 2006 |
Jurkuvenaite A, Varga K, Nowotarski K, Kirk KL, Sorscher EJ, Li Y, Clancy JP, Bebok Z, Collawn JF. Mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis. The Journal of Biological Chemistry. 281: 3329-34. PMID 16339147 DOI: 10.1074/Jbc.M508131200 |
0.372 |
|
| 2006 |
Sorscher EJ, Harris J, Alexander M, Rottgers A, Hardy K, Ponnazhagan S, Collawn JF, McClintock J, Amsler CD, Webster A, Maddry J, Baker BJ, Hong JS. Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening. Gene Therapy. 13: 781-8. PMID 16307002 DOI: 10.1038/Sj.Gt.3302676 |
0.35 |
|
| 2006 |
Jaime J, Jabbour N, Parker W, Sorscher E, Nalbantoglu J, Massie B. 18. Comparison of Antitumor Activity of Cytosine Deaminase::Uracil Phosphoribosyl Transferase (CD::UPRT) and Purine Nucleoside Phosphorylase (PNP) Suicide Genes Using Replicative but Non-Disseminative Adenovirus Vectors Molecular Therapy. 13: S8. DOI: 10.1016/J.Ymthe.2006.08.029 |
0.346 |
|
| 2005 |
Zhang Y, Parker WB, Sorscher EJ, Ealick SE. PNP anticancer gene therapy. Current Topics in Medicinal Chemistry. 5: 1259-74. PMID 16305530 DOI: 10.2174/156802605774463105 |
0.385 |
|
| 2005 |
Bebok Z, Collawn JF, Wakefield J, Parker W, Li Y, Varga K, Sorscher EJ, Clancy JP. Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers. The Journal of Physiology. 569: 601-15. PMID 16210354 DOI: 10.1113/Jphysiol.2005.096669 |
0.423 |
|
| 2005 |
Bharara S, Sorscher EJ, Gillespie GY, Lindsey JR, Hong JS, Curlee KV, Allan PW, Gadi VK, Alexander SA, Secrist JA, Parker WB, Waud WR. Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy. Human Gene Therapy. 16: 339-47. PMID 15812229 DOI: 10.1089/Hum.2005.16.339 |
0.733 |
|
| 2005 |
White AF, Mazur M, Sorscher EJ, Ponnazhagan S. 507. Modeling Adeno-Associated Virus 2 Capsid for the Identification of Targeting Ligands for Enhanced Gene Transfer to Polarized Human Airway Epithelial Cells Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.047 |
0.384 |
|
| 2004 |
Harris CM, Mendes F, Dragomir A, Doull IJ, Carvalho-Oliveira I, Bebok Z, Clancy JP, Eubanks V, Sorscher EJ, Roomans GM, Amaral MD, McPherson MA, Penque D, Dormer RL. Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 43-8. PMID 15463924 DOI: 10.1016/J.Jcf.2004.05.009 |
0.37 |
|
| 2004 |
Hong JS, Waud WR, Levasseur DN, Townes TM, Wen H, McPherson SA, Moore BA, Bebok Z, Allan PW, Secrist JA, Parker WB, Sorscher EJ. Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene. Cancer Research. 64: 6610-5. PMID 15374975 DOI: 10.1158/0008-5472.Can-04-0012 |
0.395 |
|
| 2004 |
Burrus JK, Matheson WD, Hong JS, Sorscher EJ, Balkovetz DF. Hepatocyte growth factor stimulates adenoviral-mediated gene transfer across the apical membrane of epithelial cells. The Journal of Gene Medicine. 6: 624-30. PMID 15170733 DOI: 10.1002/Jgm.552 |
0.327 |
|
| 2004 |
Varga K, Jurkuvenaite A, Wakefield J, Hong JS, Guimbellot JS, Venglarik CJ, Niraj A, Mazur M, Sorscher EJ, Collawn JF, Bebök Z. Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines. The Journal of Biological Chemistry. 279: 22578-84. PMID 15066992 DOI: 10.1074/Jbc.M401522200 |
0.746 |
|
| 2004 |
Hentchel-Franks K, Lozano D, Eubanks-Tarn V, Cobb B, Fan L, Oster R, Sorscher E, Clancy JP. Activation of airway cl- secretion in human subjects by adenosine. American Journal of Respiratory Cell and Molecular Biology. 31: 140-6. PMID 15039139 DOI: 10.1165/Rcmb.2004-0012Oc |
0.658 |
|
| 2004 |
Zsembery A, Fortenberry JA, Liang L, Bebok Z, Tucker TA, Boyce AT, Braunstein GM, Welty E, Bell PD, Sorscher EJ, Clancy JP, Schwiebert EM. Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry. The Journal of Biological Chemistry. 279: 10720-9. PMID 14701827 DOI: 10.1074/Jbc.M313391200 |
0.384 |
|
| 2004 |
Curlee KV, Parker WB, Sorscher EJ. Tumor sensitization to purine analogs by E. coli PNP. Methods in Molecular Medicine. 90: 223-45. PMID 14657566 DOI: 10.1385/1-59259-429-8:223 |
0.717 |
|
| 2003 |
Bennett EM, Anand R, Allan PW, Hassan AE, Hong JS, Levasseur DN, McPherson DT, Parker WB, Secrist JA, Sorscher EJ, Townes TM, Waud WR, Ealick SE. Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system. Chemistry & Biology. 10: 1173-81. PMID 14700625 DOI: 10.1016/J.Chembiol.2003.11.008 |
0.382 |
|
| 2003 |
Jones JR, Schwiebert EM, DuVall MD, Venglarik CJ, Wen H, Kovacs T, Mazur M, Clancy JP, Braunstein G, Bates E, Greer H, Maddry JA, Sorscher EJ. Activation of chloride secretion in cystic fibrosis cells and tissues by the substituted imidazole SRI 2931. Biochemistry. 42: 13241-9. PMID 14609335 DOI: 10.1021/Bi0340447 |
0.403 |
|
| 2003 |
Curlee KV, Hong JS, Clancy JP, King SA, Hunter E, Berdiev B, Benos D, Sommerfelt MA, Sorscher EJ, Sakalian M. Membrane transplantation to correct integral membrane protein defects. Journal of Molecular Medicine (Berlin, Germany). 81: 511-20. PMID 12879148 DOI: 10.1007/S00109-003-0446-7 |
0.725 |
|
| 2003 |
Cobb BR, Fan L, Kovacs TE, Sorscher EJ, Clancy JP. Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. American Journal of Respiratory Cell and Molecular Biology. 29: 410-8. PMID 12714375 DOI: 10.1165/Rcmb.2002-0247Oc |
0.67 |
|
| 2003 |
Gadi VK, Alexander SD, Waud WR, Allan PW, Parker WB, Sorscher EJ. A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration. The Journal of Pharmacology and Experimental Therapeutics. 304: 1280-4. PMID 12604707 DOI: 10.1124/Jpet.102.044743 |
0.35 |
|
| 2003 |
Naren AP, Cobb B, Li C, Roy K, Nelson D, Heda GD, Liao J, Kirk KL, Sorscher EJ, Hanrahan J, Clancy JP. A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proceedings of the National Academy of Sciences of the United States of America. 100: 342-6. PMID 12502786 DOI: 10.1073/Pnas.0135434100 |
0.649 |
|
| 2003 |
Parker WB, Allan PW, Hassan AE, Secrist JA, Sorscher EJ, Waud WR. Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer Gene Therapy. 10: 23-9. PMID 12489025 DOI: 10.1038/Sj.Cgt.7700520 |
0.301 |
|
| 2002 |
Peter K, Varga K, Bebok Z, McNicholas-Bevensee CM, Schwiebert L, Sorscher EJ, Schwiebert EM, Collawn JF. Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression. The Journal of Biological Chemistry. 277: 49952-7. PMID 12376531 DOI: 10.1074/Jbc.M209275200 |
0.363 |
|
| 2002 |
Du M, Jones JR, Lanier J, Keeling KM, Lindsey JR, Tousson A, Bebök Z, Whitsett JA, Dey CR, Colledge WH, Evans MJ, Sorscher EJ, Bedwell DM. Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene. Journal of Molecular Medicine (Berlin, Germany). 80: 595-604. PMID 12226741 DOI: 10.1007/S00109-002-0363-1 |
0.365 |
|
| 2002 |
Eidelman O, BarNoy S, Razin M, Zhang J, McPhie P, Lee G, Huang Z, Sorscher EJ, Pollard HB. Role for phospholipid interactions in the trafficking defect of Delta F508-CFTR. Biochemistry. 41: 11161-70. PMID 12220181 DOI: 10.1021/Bi020289S |
0.352 |
|
| 2002 |
Bebok Z, Varga K, Hicks JK, Venglarik CJ, Kovacs T, Chen L, Hardiman KM, Collawn JF, Sorscher EJ, Matalon S. Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia. The Journal of Biological Chemistry. 277: 43041-9. PMID 12194970 DOI: 10.1074/Jbc.M203154200 |
0.401 |
|
| 2002 |
Falany JL, Greer H, Kovacs T, Sorscher EJ, Falany CN. Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis. The Biochemical Journal. 364: 115-20. PMID 11988083 DOI: 10.1042/Bj3640115 |
0.311 |
|
| 2002 |
Curlee KV, Sorscher EJ. Design of gene therapy clinical trials in CF patients. Methods in Molecular Medicine. 70: 575-84. PMID 11917552 DOI: 10.1385/1-59259-187-6:575 |
0.716 |
|
| 2002 |
Myles C, Sorscher E, Matalon S. Enhancement of adenovirus-mediated gene transfer in lungs and epithelial cells by EGTA. Chest. 121: 35S. PMID 11893677 DOI: 10.1378/Chest.121.3_Suppl.35S |
0.32 |
|
| 2002 |
Cobb BR, Ruiz F, King CM, Fortenberry J, Greer H, Kovacs T, Sorscher EJ, Clancy JP. A(2) adenosine receptors regulate CFTR through PKA and PLA(2). American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L12-25. PMID 11741811 DOI: 10.1152/Ajplung.2002.282.1.L12 |
0.684 |
|
| 2001 |
Gao L, Yankaskas JR, Fuller CM, Sorscher EJ, Matalon S, Forman HJ, Venglarik CJ. Chlorzoxazone or 1-EBIO increases Na+ absorption across cystic fibrosis airway epithelial cells American Journal of Physiology - Lung Cellular and Molecular Physiology. 281. PMID 11597903 DOI: 10.1152/Ajplung.2001.281.5.L1123 |
0.372 |
|
| 2001 |
Clancy JP, Bebök Z, Ruiz F, King C, Jones J, Walker L, Greer H, Hong J, Wing L, Macaluso M, Lyrene R, Sorscher EJ, Bedwell DM. Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 163: 1683-92. PMID 11401894 DOI: 10.1164/Ajrccm.163.7.2004001 |
0.347 |
|
| 2001 |
Ruiz FE, Clancy JP, Perricone MA, Bebok Z, Hong JS, Cheng SH, Meeker DP, Young KR, Schoumacher RA, Weatherly MR, Wing L, Morris JE, Sindel L, Rosenberg M, van Ginkel FW, ... ... Sorscher EJ, et al. A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis. Human Gene Therapy. 12: 751-61. PMID 11339892 DOI: 10.1089/104303401750148667 |
0.31 |
|
| 2000 |
Gadi VK, Alexander SD, Kudlow JE, Allan P, Parker WB, Sorscher EJ. In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells Gene Therapy. 7: 1738-1743. PMID 11083495 DOI: 10.1038/Sj.Gt.3301286 |
0.399 |
|
| 1999 |
Ballard ST, Trout L, Bebök Z, Sorscher EJ, Crews A. CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands American Journal of Physiology - Lung Cellular and Molecular Physiology. 277. PMID 10516209 DOI: 10.1152/Ajplung.1999.277.4.L694 |
0.337 |
|
| 1999 |
Taylor AL, Schwiebert LM, Smith JJ, King C, Jones JR, Sorscher EJ, Schwiebert EM. Epithelial P2X purinergic receptor channel expression and function. The Journal of Clinical Investigation. 104: 875-84. PMID 10510328 DOI: 10.1172/Jci7270 |
0.401 |
|
| 1999 |
Secrist JA, Parker WB, Allan PW, Bennett LL, Waud WR, Truss JW, Fowler AT, Montgomery JA, Ealick SE, Wells AH, Gillespie GY, Gadi VK, Sorscher EJ. Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase. Nucleosides & Nucleotides. 18: 745-57. PMID 10432677 DOI: 10.1080/15257779908041562 |
0.312 |
|
| 1999 |
Gadi VK, Zou N, Liu JS, Cheng S, Broker TR, Sorscher EJ, Chow LT. Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells. American Journal of Respiratory Cell and Molecular Biology. 20: 1001-6. PMID 10226070 DOI: 10.1165/Ajrcmb.20.5.3479 |
0.353 |
|
| 1999 |
Meacham GC, Lu Z, King S, Sorscher E, Tousson A, Cyr DM. The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. The Embo Journal. 18: 1492-505. PMID 10075921 DOI: 10.1093/Emboj/18.6.1492 |
0.341 |
|
| 1999 |
Clancy JP, Ruiz FE, Sorscher EJ. Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway. The American Journal of Physiology. 276: C361-9. PMID 9950763 DOI: 10.1152/Ajpcell.1999.276.2.C361 |
0.383 |
|
| 1998 |
Bebök Z, Mazzochi C, King SA, Hong JS, Sorscher EJ. The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary. The Journal of Biological Chemistry. 273: 29873-8. PMID 9792704 DOI: 10.1074/Jbc.273.45.29873 |
0.38 |
|
| 1998 |
Clancy JP, Hong JS, Bebök Z, King SA, Demolombe S, Bedwell DM, Sorscher EJ. Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain 1 (NBD-1) and CFTR truncated within NBD-1 target to the epithelial plasma membrane and increase anion permeability. Biochemistry. 37: 15222-30. PMID 9790686 DOI: 10.1021/Bi980436F |
0.397 |
|
| 1998 |
King SA, Sorscher EJ. Recombinant synthesis of cystic fibrosis transmembrane conductance regulator and functional nucleotide-binding domains. Methods in Enzymology. 292: 686-97. PMID 9711592 DOI: 10.1016/S0076-6879(98)92053-5 |
0.364 |
|
| 1998 |
Bebök Z, Venglarik CJ, Pánczél Z, Jilling T, Kirk KL, Sorscher EJ. Activation of ΔF508 CFTR in an epithelial monolayer American Journal of Physiology - Cell Physiology. 275. PMID 9688615 DOI: 10.1152/Ajpcell.1998.275.2.C599 |
0.4 |
|
| 1998 |
Hughes BW, King SA, Allan PW, Parker WB, Sorscher EJ. Cell to cell contact is not required for bystander cell killing by Escherichia coli purine nucleoside phosphorylase. The Journal of Biological Chemistry. 273: 2322-8. PMID 9442077 DOI: 10.1074/Jbc.273.4.2322 |
0.365 |
|
| 1997 |
Clancy JP, Bebök Z, Sorscher EJ. Purification, characterization, and expression of CFTR nucleotide-binding domains. Journal of Bioenergetics and Biomembranes. 29: 475-82. PMID 9511932 DOI: 10.1023/A:1022487024031 |
0.32 |
|
| 1997 |
Bedwell DM, Kaenjak A, Benos DJ, Bebok Z, Bubien JK, Hong J, Tousson A, Clancy JP, Sorscher EJ. Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. Nature Medicine. 3: 1280-4. PMID 9359706 DOI: 10.1038/Nm1197-1280 |
0.398 |
|
| 1997 |
Parker WB, King SA, Allan PW, Bennett LL, Secrist JA, Montgomery JA, Gilbert KS, Waud WR, Wells AH, Gillespie GY, Sorscher EJ. In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase. Human Gene Therapy. 8: 1637-44. PMID 9322865 DOI: 10.1089/Hum.1997.8.14-1637 |
0.372 |
|
| 1997 |
Haddad IY, Sorscher EJ, Garver RI, Hong J, Tzeng E, Matalon S. Modulation of Adenovirus-mediated Gene Transfer by Nitric Oxide American Journal of Respiratory Cell and Molecular Biology. 16: 501-509. PMID 9160832 DOI: 10.1165/Ajrcmb.16.5.9160832 |
0.353 |
|
| 1997 |
Walker LC, Venglarik CJ, Aubin G, Weatherly MR, McCarty NA, Lesnick B, Ruiz F, Clancy JP, Sorscher EJ. Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR. American Journal of Respiratory and Critical Care Medicine. 155: 1684-9. PMID 9154877 DOI: 10.1164/Ajrccm.155.5.9154877 |
0.387 |
|
| 1996 |
Walker L, Kulomaa MS, Bebok Z, Parker WB, Allan P, Logan J, Huang Z, Reynolds RC, King S, Sorscher EJ. Development of drug targeting based on recombinant expression of the chicken avidin gene Journal of Drug Targeting. 4: 41-49. PMID 8798877 DOI: 10.3109/10611869609046259 |
0.318 |
|
| 1995 |
Jovov B, Ismailov II, Berdiev BK, Fuller CM, Sorscher EJ, Dedman JR, Kaetzel MA, Benos DJ. Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels Journal of Biological Chemistry. 270: 29194-29200. PMID 7493947 DOI: 10.1074/Jbc.270.49.29194 |
0.384 |
|
| 1995 |
Hasty P, O'Neal WK, Liu KQ, Morris AP, Bebok Z, Shumyatsky GB, Jilling T, Sorscher EJ, Bradley A, Beaudet AL. Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene. Somatic Cell and Molecular Genetics. 21: 177-87. PMID 7482032 DOI: 10.1007/Bf02254769 |
0.341 |
|
| 1994 |
Weber E, Berta G, Tousson A, St. John P, Green MW, Gopalokrishnan U, Jilling T, Sorscher EJ, Elton TS, Abrahamson DR, Kirk KL. Expression and polarized targeting of a rab3 isoform in epithelial cells Journal of Cell Biology. 125: 583-594. PMID 8175882 DOI: 10.1083/Jcb.125.3.583 |
0.36 |
|
| 1994 |
Sommerfelt MA, Sorscher EJ. Chapter 32 Use of Fluorescence-Activated Cell Sorting for Rapid Isolation of Insect Cells Harboring Recombinant Baculovirus Methods in Cell Biology. 42: 563-574. PMID 7877509 DOI: 10.1016/S0091-679X(08)61095-X |
0.312 |
|
| 1994 |
Sorscher EJ, Logan JJ, Frizzell RA, Lyrene RK, Bebok Z, Dong JY, Duvall MD, Felgner PL, Matalon S, Walker L. Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway. Human Gene Therapy. 5: 1259-77. PMID 7531503 DOI: 10.1089/Hum.1994.5.10-1259 |
0.301 |
|
| 1994 |
Logan J, Hiestand D, Daram P, Huang Z, Muccio DD, Hartman J, Haley B, Cook WJ, Sorscher EJ. Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding Journal of Clinical Investigation. 94: 228-236. PMID 7518829 DOI: 10.1172/Jci117311 |
0.316 |
|
| 1993 |
Peng S, Sommerfelt M, Logan J, Huang Z, Jilling T, Kirk K, Hunter E, Sorscher E. One-step affinity isolation of recombinant protein using the baculovirus/insect cell expression system. Protein Expression and Purification. 4: 95-100. PMID 7682463 DOI: 10.1006/Prep.1993.1014 |
0.341 |
|
| 1992 |
Bradbury NA, Jilling T, Berta G, Sorscher EJ, Bridges RJ, Kirk KL. Regulation of plasma membrane recycling by CFTR Science. 256: 530-532. PMID 1373908 DOI: 10.1126/Science.1373908 |
0.434 |
|
| 1992 |
Sorscher EJ, Fuller CM, Bridges RJ, Tousson A, Marchase RB, Brinkley BR, Frizzell RA, Benos DJ. Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptide American Journal of Physiology - Cell Physiology. 262. PMID 1310206 DOI: 10.1152/Ajpcell.1992.262.1.C136 |
0.317 |
|
| 1991 |
Sorscher EJ, Kirk KL, Weaver ML, Jilling T, Edwin Blalock J, Leboeuf RD. Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells Proceedings of the National Academy of Sciences of the United States of America. 88: 7759-7762. PMID 1715578 DOI: 10.1073/Pnas.88.17.7759 |
0.412 |
|
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