Rama Khokha - Publications

University of Toronto, Toronto, ON, Canada 
Molecular Biology, Medical Biophysics

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Joshi PA, Waterhouse PD, Kasaian K, Fang H, Gulyaeva O, Sul HS, Boutros PC, Khokha R. PDGFRα stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Nature Communications. 10: 1760. PMID 30988300 DOI: 10.1038/s41467-019-09748-z  0.84
2016 Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, ... ... Khokha R, et al. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research. PMID 27241552 DOI: 10.1038/cr.2016.69  0.84
2015 Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports. 4: 313-322. PMID 28447939 DOI: 10.1016/j.stemcr.2015.01.011  0.84
2015 Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R. RANKL blockade prevents and treats aggressive osteosarcomas. Science Translational Medicine. 7: 317ra197. PMID 26659571 DOI: 10.1126/scitranslmed.aad0295  0.8
2015 Joshi PA, Goodwin PJ, Khokha R. Progesterone and Synthetic Progestin Controversies-Reply. Jama Oncology. 1: 987-8. PMID 26448288 DOI: 10.1001/jamaoncol.2015.2294  0.84
2015 Joshi PA, Goodwin PJ, Khokha R. Progesterone Exposure and Breast Cancer Risk: Understanding the Biological Roots. Jama Oncology. 1: 283-5. PMID 26181171 DOI: 10.1001/jamaoncol.2015.0512  0.84
2015 Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/j.stemcr.2015.05.012  0.84
2015 Jackson HW, Hojilla CV, Weiss A, Sanchez OH, Wood GA, Khokha R. Timp3 deficient mice show resistance to developing breast cancer. Plos One. 10: e0120107. PMID 25807548 DOI: 10.1371/journal.pone.0120107  0.48
2015 Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R. PKA signaling drives mammary tumorigenesis through Src. Oncogene. 34: 1160-73. PMID 24662820 DOI: 10.1038/onc.2014.41  0.84
2014 Alexander CM, Joshi PA, Khokha R. Fully interlocking: a story of teamwork among breast epithelial cells. Developmental Cell. 28: 114-5. PMID 24480641 DOI: 10.1016/j.devcel.2014.01.011  0.84
2013 Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ. Localized interleukin-12 delivery for immunotherapy of solid tumours. Journal of Cellular and Molecular Medicine. 17: 1465-74. PMID 24251770 DOI: 10.1111/jcmm.12121  0.8
2013 Voura EB, English JL, Yu HY, Ho AT, Subarsky P, Hill RP, Hojilla CV, Khokha R. Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types. Plos One. 8: e78413. PMID 24194929 DOI: 10.1371/journal.pone.0078413  0.48
2013 Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, ... ... Khokha R, et al. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. The Journal of Experimental Medicine. 210: 1529-44. PMID 23857982 DOI: 10.1084/jem.20121337  0.84
2012 Joshi PA, Di Grappa MA, Khokha R. Active allies: hormones, stem cells and the niche in adult mammopoiesis. Trends in Endocrinology and Metabolism: Tem. 23: 299-309. PMID 22613704 DOI: 10.1016/j.tem.2012.04.002  0.84
2012 Joshi PA, Khokha R. The mammary stem cell conundrum: is it unipotent or multipotent? Breast Cancer Research : Bcr. 14: 305. PMID 22424095 DOI: 10.1186/bcr3123  0.84
2012 Beristain AG, Narala SR, Di Grappa MA, Khokha R. Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. Journal of Cell Science. 125: 943-55. PMID 22421365 DOI: 10.1242/jcs.094029  0.8
2011 Hojilla CV, Jackson HW, Khokha R. TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence. Plos One. 6: e26718. PMID 22053204 DOI: 10.1371/journal.pone.0026718  0.48
2010 Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468: 98-102. PMID 20881962 DOI: 10.1038/nature09387  0.84
2010 Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood. 116: 4474-82. PMID 20798233 DOI: 10.1182/blood-2010-01-266528  0.48
2010 Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, ... ... Khokha R, et al. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. The Journal of Clinical Investigation. 120: 3310-25. PMID 20697156 DOI: 10.1172/JCI42391  0.8
2010 Murthy A, Defamie V, Smookler DS, Di Grappa MA, Horiuchi K, Federici M, Sibilia M, Blobel CP, Khokha R. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. The Journal of Clinical Investigation. 120: 2731-44. PMID 20628198 DOI: 10.1172/JCI42686  0.8
2010 Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R. Progesterone induces adult mammary stem cell expansion. Nature. 465: 803-7. PMID 20445538 DOI: 10.1038/nature09091  0.84
2008 Hojilla CV, Wood GA, Khokha R. Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. Breast Cancer Research : Bcr. 10: 205. PMID 18394187 DOI: 10.1186/bcr1980  0.48
2007 Hojilla CV, Kim I, Kassiri Z, Fata JE, Fang H, Khokha R. Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3. Journal of Cell Science. 120: 1050-60. PMID 17327279 DOI: 10.1242/jcs.003335  0.48
2006 Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, ... Khokha R, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440: 692-6. PMID 16572175 DOI: 10.1038/nature04524  0.48
2006 Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. Journal of Immunology (Baltimore, Md. : 1950). 176: 721-5. PMID 16393953  0.88
2005 Federici M, Hribal ML, Menghini R, Kanno H, Marchetti V, Porzio O, Sunnarborg SW, Rizza S, Serino M, Cunsolo V, Lauro D, Mauriello A, Smookler DS, Sbraccia P, Sesti G, ... ... Khokha R, et al. Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. The Journal of Clinical Investigation. 115: 3494-505. PMID 16294222 DOI: 10.1172/JCI26052  0.48
2005 Mohammed FF, Khokha R. Thinking outside the cell: proteases regulate hepatocyte division. Trends in Cell Biology. 15: 555-63. PMID 16150595 DOI: 10.1016/j.tcb.2005.08.009  0.88
2005 Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circulation Research. 97: 380-90. PMID 16037568 DOI: 10.1161/01.RES.0000178789.16929.cf  0.88
2005 Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R. Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (Baltimore, Md.). 41: 857-67. PMID 15726641 DOI: 10.1002/hep.20618  0.88
2004 Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nature Genetics. 36: 969-77. PMID 15322543 DOI: 10.1038/ng1413  0.88
2004 Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 110: 2401-9. PMID 15262835 DOI: 10.1161/01.CIR.0000134959.83967.2D  0.48
2003 Hojilla CV, Mohammed FF, Khokha R. Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development. British Journal of Cancer. 89: 1817-21. PMID 14612884 DOI: 10.1038/sj.bjc.6601327  0.88
2003 Griffiths EK, Sanchez O, Mill P, Krawczyk C, Hojilla CV, Rubin E, Nau MM, Khokha R, Lipkowitz S, Hui CC, Penninger JM. Cbl-3-deficient mice exhibit normal epithelial development. Molecular and Cellular Biology. 23: 7708-18. PMID 14560016 DOI: 10.1128/MCB.23.21.7708-7718.2003  0.48
2003 Mohammed FF, Smookler DS, Khokha R. Metalloproteinases, inflammation, and rheumatoid arthritis. Annals of the Rheumatic Diseases. 62: ii43-7. PMID 14532148  0.88
2003 Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KLM, Edwards DR, Khokha R. Insulin-like Growth Factor-II Regulates PTEN Expression in the Mammary Gland Journal of Biological Chemistry. 278: 50422-50427. PMID 14517213 DOI: 10.1074/jbc.M306894200  0.48
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