David P. Siderovski - Publications

University of North Carolina, Chapel Hill, Chapel Hill, NC 
Pharmacology, General Biophysics, Molecular Biology

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kaski SW, White AN, Gross JD, Trexler KR, Wix K, Harland AA, Prisinzano TE, Aube J, Kinsey SG, Kenakin T, Siderovski D, Setola V. Preclinical testing of nalfurafine as an opioid-sparing adjuvant that potentiates analgesia by the mu opioid receptor-targeting agonist morphine. The Journal of Pharmacology and Experimental Therapeutics. PMID 31492823 DOI: 10.1124/jpet.118.255661  0.36
2019 Schroer AB, Mohamed JS, Willard MD, Setola V, Oestreich E, Siderovski DP. A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation. Plos One. 14: e0216167. PMID 31408461 DOI: 10.1371/journal.pone.0216167  0.6
2019 Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, Schroer AB, McElligott ZA, Siderovski DP, Setola V. Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31141817 DOI: 10.1038/s41386-019-0423-7  0.36
2019 Purnell PR, Addicks BL, Zalzal HG, Shapiro S, Wen S, Ramadan HH, Setola V, Siderovski DP. Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis. International Archives of Allergy and Immunology. 1-6. PMID 31137020 DOI: 10.1159/000499875  0.36
2019 Kaski SW, Brooks S, Wen S, Haut MW, Siderovski DP, Berry JH, Lander LR, Setola V. Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West Virginia. Journal of Opioid Management. 15: 103-109. PMID 31057342 DOI: 10.5055/jom.2019.0491  0.36
2018 Schroer AB, Gross JD, Kaski SW, Wix K, Siderovski DP, Vandenbeuch A, Setola V. Development of full sweet, umami, and bitter taste responsiveness requires Regulator of G protein Signaling-21 (RGS21). Chemical Senses. PMID 29701767 DOI: 10.1093/chemse/bjy024  0.36
2018 Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V. Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. Journal of Psychopharmacology (Oxford, England). 269881117742100. PMID 29364035 DOI: 10.1177/0269881117742100  0.36
2015 Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, Guillin O, Dikeos D, Georgantopoulos G, Papadimitriou G, Curtis L, Méary A, Schürhoff F, Jamain S, Avramopoulos D, ... ... Siderovski DP, et al. Correction: Exome Sequencing in 53 Sporadic Cases of Schizophrenia Identifies 18 Putative Candidate Genes. Plos One. 10: e0141630. PMID 26488584 DOI: 10.1371/journal.pone.0141630  0.36
2015 Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Molecular Cell. 58: 794-803. PMID 25982117 DOI: 10.1016/j.molcel.2015.04.017  0.96
2015 Bosch DE, Siderovski DP. Entamoeba histolytica RacC selectively engages p21-activated kinase effectors. Biochemistry. 54: 404-12. PMID 25529118 DOI: 10.1021/bi501226f  0.96
2014 Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, Guillin O, Dikeos D, Georgantopoulos G, Papadimitriou G, Curtis L, Méary A, Schürhoff F, Jamain S, Avramopoulos D, ... ... Siderovski DP, et al. Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes. Plos One. 9: e112745. PMID 25420024 DOI: 10.1371/journal.pone.0112745  0.96
2014 Giguère PM, Gall BJ, Ezekwe EA, Laroche G, Buckley BK, Kebaier C, Wilson JE, Ting JP, Siderovski DP, Duncan JA. G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3. The Journal of Biological Chemistry. 289: 33245-57. PMID 25271165 DOI: 10.1074/jbc.M114.578393  0.96
2014 Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. The Journal of Biological Chemistry. 289: 1580-91. PMID 24297163 DOI: 10.1074/jbc.M113.528273  0.96
2014 Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R. Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells. The Journal of Pharmacology and Experimental Therapeutics. 348: 12-24. PMID 24163441 DOI: 10.1124/jpet.113.204586  0.96
2014 Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP. RGS21, a regulator of taste and mucociliary clearance? The Laryngoscope. 124: E56-63. PMID 23908053 DOI: 10.1002/lary.24326  0.96
2013 Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP. G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. Journal of Leukocyte Biology. 94: 1243-51. PMID 23935208 DOI: 10.1189/jlb.0213097  0.96
2013 Garcia-Olivares J, Torres-Salazar D, Owens WA, Baust T, Siderovski DP, Amara SG, Zhu J, Daws LC, Torres GE. Inhibition of dopamine transporter activity by G protein βγ subunits. Plos One. 8: e59788. PMID 23555781 DOI: 10.1371/journal.pone.0059788  0.96
2013 Bosch DE, Siderovski DP. G protein signaling in the parasite Entamoeba histolytica. Experimental & Molecular Medicine. 45: e15. PMID 23519208 DOI: 10.1038/emm.2013.30  0.96
2013 Giguère PM, Billard MJ, Laroche G, Buckley BK, Timoshchenko RG, McGinnis MW, Esserman D, Foreman O, Liu P, Siderovski DP, Tarrant TK. G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. Molecular Immunology. 54: 193-8. PMID 23280397 DOI: 10.1016/j.molimm.2012.12.001  0.76
2013 Bosch DE, Kimple AJ, Manning AJ, Muller RE, Willard FS, Machius M, Rogers SL, Siderovski DP. Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Structure (London, England : 1993). 21: 65-75. PMID 23260656 DOI: 10.1016/j.str.2012.11.012  0.96
2013 Bosch DE, Siderovski DP. Structural determinants of ubiquitin conjugation in Entamoeba histolytica. The Journal of Biological Chemistry. 288: 2290-302. PMID 23209297 DOI: 10.1074/jbc.M112.417337  0.96
2012 Bosch DE, Kimple AJ, Muller RE, Giguère PM, Machius M, Willard FS, Temple BR, Siderovski DP. Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica. Plos Pathogens. 8: e1003040. PMID 23166501 DOI: 10.1371/journal.ppat.1003040  0.96
2012 Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. The Journal of Biological Chemistry. 287: 41706-19. PMID 23095746 DOI: 10.1074/jbc.M112.423806  0.96
2012 Bosch DE, Yang B, Siderovski DP. Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin. Biochemistry. 51: 8791-801. PMID 23050667 DOI: 10.1021/bi300954g  0.96
2012 Giguère PM, Laroche G, Oestreich EA, Duncan JA, Siderovski DP. Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein. The Journal of Biological Chemistry. 287: 31270-9. PMID 22843681 DOI: 10.1074/jbc.M112.394379  0.96
2012 Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 36: 933-46. PMID 22749352 DOI: 10.1016/j.immuni.2012.03.025  0.96
2012 Johnston CA, Siderovski DP. Retraction for Johnston and Siderovski. Structural basis for nucleotide exchange on Gαi subunits and receptor coupling specificity. Proceedings of the National Academy of Sciences of the United States of America. 109: 1808. PMID 22408789  0.96
2012 Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP. A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. Plos Pathogens. 8: e1002553. PMID 22383884 DOI: 10.1371/journal.ppat.1002553  0.96
2012 Bosch DE, Zielinski T, Lowery RG, Siderovski DP. Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit2.8. PMID 22382998 DOI: 10.1002/0471141755.ph0208s56  0.96
2012 Giguère PM, Laroche G, Oestreich EA, Siderovski DP. G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits. The Journal of Biological Chemistry. 287: 4863-74. PMID 22167191 DOI: 10.1074/jbc.M111.311712  0.76
2011 Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R. β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proceedings of the National Academy of Sciences of the United States of America. 108: 19713-8. PMID 22080612 DOI: 10.1073/pnas.1110226108  0.96
2011 Bosch DE, Wittchen ES, Qiu C, Burridge K, Siderovski DP. Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica. The Journal of Biological Chemistry. 286: 39236-46. PMID 21930699 DOI: 10.1074/jbc.M111.253898  0.96
2011 Kimple AJ, Bosch DE, Giguère PM, Siderovski DP. Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacological Reviews. 63: 728-49. PMID 21737532 DOI: 10.1124/pr.110.003038  0.96
2011 Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY. Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. Nature Structural & Molecular Biology. 18: 846-53. PMID 21685921 DOI: 10.1038/nsmb.2068  0.96
2011 Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B. Computational design of the sequence and structure of a protein-binding peptide. Journal of the American Chemical Society. 133: 4190-2. PMID 21388199 DOI: 10.1021/ja110296z  0.96
2011 Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP. Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. The Journal of Biological Chemistry. 286: 3351-8. PMID 21115486 DOI: 10.1074/jbc.M110.190496  0.96
2010 Muller RE, Klein KR, Hutsell SQ, Siderovski DP, Kimple AJ. A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization. Assay and Drug Development Technologies. 8: 621-4. PMID 20662737 DOI: 10.1089/adt.2010.0286  0.76
2010 Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. American Journal of Physiology. Cell Physiology. 299: C654-64. PMID 20573995 DOI: 10.1152/ajpcell.00441.2009  0.96
2010 Lambert NA, Johnston CA, Cappell SD, Kuravi S, Kimple AJ, Willard FS, Siderovski DP. Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proceedings of the National Academy of Sciences of the United States of America. 107: 7066-71. PMID 20351284 DOI: 10.1073/pnas.0912934107  0.96
2010 Kimple AJ, Muller RE, Siderovski DP, Willard FS. A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance. Methods in Molecular Biology (Clifton, N.J.). 627: 91-100. PMID 20217615 DOI: 10.1007/978-1-60761-670-2_5  0.76
2010 Hutsell SQ, Kimple RJ, Siderovski DP, Willard FS, Kimple AJ. High-affinity immobilization of proteins using biotin- and GST-based coupling strategies. Methods in Molecular Biology (Clifton, N.J.). 627: 75-90. PMID 20217614 DOI: 10.1007/978-1-60761-670-2_4  0.76
2010 Nakamura K, Kimple AJ, Siderovski DP, Johnson GL. PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. The Journal of Biological Chemistry. 285: 2077-89. PMID 19903815 DOI: 10.1074/jbc.M109.065102  0.96
2009 Zielinski T, Kimple AJ, Hutsell SQ, Koeff MD, Siderovski DP, Lowery RG. Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity. Journal of Biomolecular Screening. 14: 1195-206. PMID 19820068 DOI: 10.1177/1087057109347473  0.76
2009 Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). The Journal of Biological Chemistry. 284: 19402-11. PMID 19478087 DOI: 10.1074/jbc.M109.024711  0.96
2009 Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Plos One. 4: e4884. PMID 19319189 DOI: 10.1371/journal.pone.0004884  0.96
2009 Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM. Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry. 48: 2630-42. PMID 19222191 DOI: 10.1021/bi801853a  0.96
2009 Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. The Journal of Clinical Investigation. 119: 408-20. PMID 19127022 DOI: 10.1172/JCI35620  0.96
2008 Johnston CA, Willard MD, Kimple AJ, Siderovski DP, Willard FS. A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction. Plant Signaling & Behavior. 3: 1067-76. PMID 19513240  0.96
2008 Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP. A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. The Journal of Biological Chemistry. 283: 36698-710. PMID 18984596 DOI: 10.1074/jbc.M804936200  0.96
2008 Johnston CA, Kimple AJ, Giguère PM, Siderovski DP. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Structure (London, England : 1993). 16: 1086-94. PMID 18611381 DOI: 10.1016/j.str.2008.04.010  0.96
2008 Kimple AJ, Yasgar A, Hughes M, Jadhav A, Willard FS, Muller RE, Austin CP, Inglese J, Ibeanu GC, Siderovski DP, Simeonov A. A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Combinatorial Chemistry & High Throughput Screening. 11: 396-409. PMID 18537560  0.76
2008 Johnston CA, Willard FS, Ramer JK, Blaesius R, Roques CN, Siderovski DP. State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics. Combinatorial Chemistry & High Throughput Screening. 11: 370-81. PMID 18537558 DOI: 10.2174/138620708784534798  0.96
2008 Willard FS, Siderovski DP. GPCR high throughput screening (part 1). Combinatorial Chemistry & High Throughput Screening. 11: 336. PMID 18537554  0.68
2008 Johnston CA, Afshar K, Snyder JT, Tall GG, Gönczy P, Siderovski DP, Willard FS. Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans. The Journal of Biological Chemistry. 283: 21550-8. PMID 18519563 DOI: 10.1074/jbc.M803023200  0.96
2008 Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proceedings of the National Academy of Sciences of the United States of America. 105: 6457-62. PMID 18434541 DOI: 10.1073/pnas.0801508105  0.96
2007 Johnston CA, Temple BR, Chen JG, Gao Y, Moriyama EN, Jones AM, Siderovski DP, Willard FS. Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid". Science (New York, N.Y.). 318: 914; author reply 91. PMID 17991845 DOI: 10.1126/science.1143230  0.96
2007 Johnston CA, Taylor JP, Gao Y, Kimple AJ, Grigston JC, Chen JG, Siderovski DP, Jones AM, Willard FS. GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 17317-22. PMID 17951432 DOI: 10.1073/pnas.0704751104  0.96
2007 Kimple AJ, Willard FS, Giguère PM, Johnston CA, Mocanu V, Siderovski DP. The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochimica Et Biophysica Acta. 1774: 1213-20. PMID 17660054 DOI: 10.1016/j.bbapap.2007.06.002  0.96
2007 Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B. Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. Journal of Molecular Biology. 371: 1392-404. PMID 17603074 DOI: 10.1016/j.jmb.2007.05.096  0.96
2007 Johnston CA, Siderovski DP. Receptor-mediated activation of heterotrimeric G-proteins: current structural insights. Molecular Pharmacology. 72: 219-30. PMID 17430994 DOI: 10.1124/mol.107.034348  0.96
2007 Willard MD, Willard FS, Li X, Cappell SD, Snider WD, Siderovski DP. Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation. The Embo Journal. 26: 2029-40. PMID 17380122 DOI: 10.1038/sj.emboj.7601659  0.96
2007 Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proceedings of the National Academy of Sciences of the United States of America. 104: 2001-6. PMID 17264214 DOI: 10.1073/pnas.0608599104  0.96
2007 Liu H, Suresh A, Willard FS, Siderovski DP, Lu S, Naqvi NI. Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. The Embo Journal. 26: 690-700. PMID 17255942 DOI: 10.1038/sj.emboj.7601536  0.96
2007 Willard FS, Low AB, McCudden CR, Siderovski DP. Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins. Cellular Signalling. 19: 428-38. PMID 16949794 DOI: 10.1016/j.cellsig.2006.07.013  0.68
2006 Johnston CA, Lobanova ES, Shavkunov AS, Low J, Ramer JK, Blaesius R, Fredericks Z, Willard FS, Kuhlman B, Arshavsky VY, Siderovski DP. Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer. Biochemistry. 45: 11390-400. PMID 16981699 DOI: 10.1021/bi0613832  0.96
2006 Dho SE, Trejo J, Siderovski DP, McGlade CJ. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Molecular Biology of the Cell. 17: 4142-55. PMID 16837553 DOI: 10.1091/mbc.E06-02-0097  0.96
2006 Willard FS, Siderovski DP. Covalent immobilization of histidine-tagged proteins for surface plasmon resonance. Analytical Biochemistry. 353: 147-9. PMID 16620750 DOI: 10.1016/j.ab.2006.02.004  0.68
2006 Paing MM, Johnston CA, Siderovski DP, Trejo J. Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Molecular and Cellular Biology. 26: 3231-42. PMID 16581796 DOI: 10.1128/MCB.26.8.3231-3242.2006  0.96
2006 Hains MD, Wing MR, Maddileti S, Siderovski DP, Harden TK. Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. Molecular Pharmacology. 69: 2068-75. PMID 16554409 DOI: 10.1124/mol.105.017921  0.96
2006 Chasse SA, Flanary P, Parnell SC, Hao N, Cha JY, Siderovski DP, Dohlman HG. Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryotic Cell. 5: 330-46. PMID 16467474 DOI: 10.1128/EC.5.2.330-346.2006  0.96
2006 Fatemi SH, Reutiman TJ, Folsom TD, Bell C, Nos L, Fried P, Pearce DA, Singh S, Siderovski DP, Willard FS, Fukuda M. Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1888-99. PMID 16407901 DOI: 10.1038/sj.npp.1301002  0.68
2006 Willard FS, Siderovski DP. The R6A-1 peptide binds to switch II of Galphai1 but is not a GDP-dissociation inhibitor. Biochemical and Biophysical Research Communications. 339: 1107-12. PMID 16338227 DOI: 10.1016/j.bbrc.2005.11.132  0.68
2006 Willard FS, McCudden CR, Siderovski DP. G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2). Cellular Signalling. 18: 1226-34. PMID 16298104 DOI: 10.1016/j.cellsig.2005.10.003  0.68
2006 Sambi BS, Hains MD, Waters CM, Connell MC, Willard FS, Kimple AJ, Pyne S, Siderovski DP, Pyne NJ. The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cellular Signalling. 18: 971-81. PMID 16214305 DOI: 10.1016/j.cellsig.2005.08.003  0.96
2005 Zigman M, Cayouette M, Charalambous C, Schleiffer A, Hoeller O, Dunican D, McCudden CR, Firnberg N, Barres BA, Siderovski DP, Knoblich JA. Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron. 48: 539-45. PMID 16301171 DOI: 10.1016/j.neuron.2005.09.030  0.96
2005 Johnston CA, Ramer JK, Blaesius R, Fredericks Z, Watts VJ, Siderovski DP. A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity. Febs Letters. 579: 5746-50. PMID 16225870 DOI: 10.1016/j.febslet.2005.09.059  0.96
2005 Afshar K, Willard FS, Colombo K, Siderovski DP, Gönczy P. Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development (Cambridge, England). 132: 4449-59. PMID 16162648 DOI: 10.1242/dev.02039  0.96
2005 Martin-McCaffrey L, Hains MD, Pritchard GA, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ. Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 234: 438-44. PMID 16145674 DOI: 10.1002/dvdy.20555  0.48
2005 Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP. Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (London, England : 1993). 13: 1069-80. PMID 16004878 DOI: 10.1016/j.str.2005.04.007  0.96
2005 Siderovski DP, Willard FS. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. International Journal of Biological Sciences. 1: 51-66. PMID 15951850  0.68
2005 McCudden CR, Willard FS, Kimple RJ, Johnston CA, Hains MD, Jones MB, Siderovski DP. G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN. Biochimica Et Biophysica Acta. 1745: 254-64. PMID 15946753 DOI: 10.1016/j.bbamcr.2005.05.002  0.68
2005 Martin-McCaffrey L, Willard FS, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ. RGS14 is a microtubule-associated protein. Cell Cycle (Georgetown, Tex.). 4: 953-60. PMID 15917656 DOI: 10.4161/cc.4.7.1787  0.68
2005 Willard FS, Kimple AJ, Johnston CA, Siderovski DP. A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Analytical Biochemistry. 340: 341-51. PMID 15840508 DOI: 10.1016/j.ab.2005.02.015  0.96
2005 Webb CK, McCudden CR, Willard FS, Kimple RJ, Siderovski DP, Oxford GS. D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides. Journal of Neurochemistry. 92: 1408-18. PMID 15748159 DOI: 10.1111/j.1471-4159.2004.02997.x  0.96
2005 McCudden CR, Hains MD, Kimple RJ, Siderovski DP, Willard FS. G-protein signaling: back to the future. Cellular and Molecular Life Sciences : Cmls. 62: 551-77. PMID 15747061 DOI: 10.1007/s00018-004-4462-3  0.68
2005 Uhlik MT, Temple B, Bencharit S, Kimple AJ, Siderovski DP, Johnson GL. Structural and evolutionary division of phosphotyrosine binding (PTB) domains. Journal of Molecular Biology. 345: 1-20. PMID 15567406 DOI: 10.1016/j.jmb.2004.10.038  0.96
2005 Richman RW, Strock J, Hains MD, Cabanilla NJ, Lau KK, Siderovski DP, Diversé-Pierluissi M. RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel. The Journal of Biological Chemistry. 280: 1521-8. PMID 15536086 DOI: 10.1074/jbc.M406607200  0.48
2004 Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Developmental Cell. 7: 763-9. PMID 15525537 DOI: 10.1016/j.devcel.2004.10.004  0.96
2004 Kimple RJ, Willard FS, Siderovski DP. Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides. Methods in Enzymology. 390: 416-36. PMID 15488192 DOI: 10.1016/S0076-6879(04)90026-2  0.68
2004 Martin-McCaffrey L, Willard FS, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ. Analysis of interactions between regulator of G-protein signaling-14 and microtubules. Methods in Enzymology. 390: 240-58. PMID 15488182 DOI: 10.1016/S0076-6879(04)90016-X  0.68
2004 Afshar K, Willard FS, Colombo K, Johnston CA, McCudden CR, Siderovski DP, Gönczy P. RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell. 119: 219-30. PMID 15479639 DOI: 10.1016/j.cell.2004.09.026  0.96
2004 Willard FS, Siderovski DP. Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1. Methods in Enzymology. 389: 320-38. PMID 15313574 DOI: 10.1016/S0076-6879(04)89019-0  0.68
2004 Hains MD, Siderovski DP, Harden TK. Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. Methods in Enzymology. 389: 71-88. PMID 15313560 DOI: 10.1016/S0076-6879(04)89005-0  0.48
2004 Willard FS, Kimple RJ, Kimple AJ, Johnston CA, Siderovski DP. Fluorescence-based assays for RGS box function. Methods in Enzymology. 389: 56-71. PMID 15313559 DOI: 10.1016/S0076-6879(04)89004-9  0.96
2004 Jones MB, Siderovski DP, Hooks SB. The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention. Molecular Interventions. 4: 200-14. PMID 15304556 DOI: 10.1124/mi.4.4.4  0.96
2004 Willard FS, Kimple RJ, Siderovski DP. Return of the GDI: the GoLoco motif in cell division. Annual Review of Biochemistry. 73: 925-51. PMID 15189163 DOI: 10.1146/annurev.biochem.73.011303.073756  0.68
2004 Kimple RJ, Willard FS, Hains MD, Jones MB, Nweke GK, Siderovski DP. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. The Biochemical Journal. 378: 801-8. PMID 14656218 DOI: 10.1042/BJ20031686  0.68
2003 Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nature Medicine. 9: 1506-12. PMID 14608379 DOI: 10.1038/nm958  0.96
2003 Chen JG, Willard FS, Huang J, Liang J, Chasse SA, Jones AM, Siderovski DP. A seven-transmembrane RGS protein that modulates plant cell proliferation. Science (New York, N.Y.). 301: 1728-31. PMID 14500984 DOI: 10.1126/science.1087790  0.68
2003 Rojas RJ, Kimple RJ, Rossman KL, Siderovski DP, Sondek J. Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Combinatorial Chemistry & High Throughput Screening. 6: 409-18. PMID 12769685  0.56
2003 Kimple RJ, Jones MB, Shutes A, Yerxa BR, Siderovski DP, Willard FS. Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins. Combinatorial Chemistry & High Throughput Screening. 6: 399-407. PMID 12769684  0.68
2003 Colombo K, Grill SW, Kimple RJ, Willard FS, Siderovski DP, Gönczy P. Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science (New York, N.Y.). 300: 1957-61. PMID 12750478 DOI: 10.1126/science.1084146  0.68
2003 Pruitt WM, Karnoub AE, Rakauskas AC, Guipponi M, Antonarakis SE, Kurakin A, Kay BK, Sondek J, Siderovski DP, Der CJ. Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling. Biochimica Et Biophysica Acta. 1640: 61-8. PMID 12676355 DOI: 10.1016/S0167-4889(03)00002-8  0.96
2002 Kimple RJ, Willard FS, Siderovski DP. The GoLoco motif: heralding a new tango between G protein signaling and cell division. Molecular Interventions. 2: 88-100. PMID 14993354 DOI: 10.1124/mi.2.2.88  0.68
2002 Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nature Cell Biology. 4: 621-5. PMID 12134164 DOI: 10.1038/ncb833  0.96
2002 Neubig RR, Siderovski DP. Regulators of G-protein signalling as new central nervous system drug targets Nature Reviews Drug Discovery. 1: 187-197. PMID 12120503  0.96
2002 Booden MA, Siderovski DP, Der CJ. Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Molecular and Cellular Biology. 22: 4053-61. PMID 12024019 DOI: 10.1128/MCB.22.12.4053-4061.2002  0.96
2002 Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology. 9: 468-75. PMID 12006984 DOI: 10.1038/nsb796  0.96
2002 Wang Q, Liu M, Mullah B, Siderovski DP, Neubig RR. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells Journal of Biological Chemistry. 277: 24949-24958. PMID 12006602 DOI: 10.1074/jbc.M203802200  0.96
2002 Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 416: 878-81. PMID 11976690 DOI: 10.1038/416878a  0.96
2002 Siderovski DP, Snow BE, Chung S, Brothers GM, Sondek J, Betts L. Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits. Methods in Enzymology. 344: 702-23. PMID 11771422 DOI: 10.1016/S0076-6879(02)44750-7  0.96
2001 Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. The Journal of Biological Chemistry. 276: 29275-81. PMID 11387333 DOI: 10.1074/jbc.M103208200  0.96
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