Randall J. Kimple, Ph.D. - Publications

Affiliations: 
2003 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacology, General Biophysics, Molecular Biology

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Rosenberg SA, Francis D, Hullett CR, Morris ZS, Fisher MM, Brower JV, Bradley KA, Anderson BM, Bassetti MF, Kimple RJ. Readability of Online Patient Educational Resources Found on NCI-Designated Cancer Center Web Sites. Journal of the National Comprehensive Cancer Network : Jnccn. 14: 735-40. PMID 27283166  0.4
2016 Campos D, Peeters W, Nickel K, Burkel B, Bussink J, Kimple RJ, van der Kogel A, Eliceiri KW, Kissick MW. Radiation Promptly Alters Cancer Live Cell Metabolic Fluxes: An In Vitro Demonstration. Radiation Research. 185: 496-504. PMID 27128739 DOI: 10.1667/RR14093.1  0.4
2015 Romick-Rosendale LE, Hoskins EE, Privette Vinnedge LM, Foglesong GD, Brusadelli MG, Potter SS, Komurov K, Brugmann SA, Lambert P, Kimple RJ, Virts EL, Hanenberg H, Gillison ML, Wells SI. Defects in the Fanconi anemia pathway in head and neck cancer cells stimulate tumor cell invasion through DNA-PK and Rac1 signaling. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26603260 DOI: 10.1158/1078-0432.CCR-15-2209  0.4
2015 Fru LC, Adamson EB, Campos DD, Fain SB, Jacques SL, van der Kogel AJ, Nickel KP, Song C, Kimple RJ, Kissick MW. Potential role of the glycolytic oscillator in acute hypoxia in tumors. Physics in Medicine and Biology. 60: 9215-9225. PMID 26576743 DOI: 10.1088/0031-9155/60/24/9215  0.4
2015 Francis DM, Huang S, Armstrong EA, Werner LR, Hullett CR, Li C, Morris ZS, Swick AD, Kragh M, Lantto J, Kimple RJ, Harari PM. Pan-HER receptor inhibition augments radiation response in human lung and head and neck cancer models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26420857 DOI: 10.1158/1078-0432.CCR-15-1664  0.4
2015 Swick AD, Chatterjee A, De Costa AA, Kimple RJ. Modulation of therapeutic sensitivity by human papillomavirus. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 26364887 DOI: 10.1016/j.radonc.2015.09.002  0.4
2015 Liang E, Brower JV, Rice SR, Buehler DG, Saha S, Kimple RJ. Merkel Cell Carcinoma Analysis of Outcomes: A 30-Year Experience. Plos One. 10: e0129476. PMID 26053480 DOI: 10.1371/journal.pone.0129476  0.4
2015 Stein AP, Saha S, Kraninger JL, Swick AD, Yu M, Lambert PF, Kimple RJ. Prevalence of Human Papillomavirus in Oropharyngeal Cancer: A Systematic Review. Cancer Journal (Sudbury, Mass.). 21: 138-46. PMID 26049691 DOI: 10.1097/PPO.0000000000000115  0.4
2015 Brand TM, Iida M, Stein AP, Corrigan KL, Braverman CM, Coan JP, Pearson HE, Bahrar H, Fowler TL, Bednarz BP, Saha S, Yang D, Gill PS, Lingen MW, Saloura V, ... ... Kimple RJ, et al. AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2601-12. PMID 25767293 DOI: 10.1158/1078-0432.CCR-14-2648  0.4
2015 Fowler TL, Bailey AM, Bednarz BP, Kimple RJ. High-throughput detection of DNA double-strand breaks using image cytometry. Biotechniques. 58: 37-9. PMID 25605579 DOI: 10.2144/000114248  0.4
2014 Zhang K, Jones L, Lim S, Maher CA, Adkins D, Lewis J, Kimple RJ, Fertig EJ, Chung CH, Van Tine BA, Ellis MJ, Herrlich A, Michel LS. Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC. Oncotarget. 5: 9281-94. PMID 25238142  0.4
2014 Park JW, Nickel KP, Torres AD, Lee D, Lambert PF, Kimple RJ. Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 113: 337-44. PMID 25216575 DOI: 10.1016/j.radonc.2014.08.026  0.4
2014 Brand TM, Iida M, Stein AP, Corrigan KL, Braverman CM, Luthar N, Toulany M, Gill PS, Salgia R, Kimple RJ, Wheeler DL. AXL mediates resistance to cetuximab therapy. Cancer Research. 74: 5152-64. PMID 25136066 DOI: 10.1158/0008-5472.CAN-14-0294  0.4
2014 Stein AP, Saha S, Liu CZ, Hartig GK, Lambert PF, Kimple RJ. Influence of handling conditions on the establishment and propagation of head and neck cancer patient derived xenografts. Plos One. 9: e100995. PMID 24967635 DOI: 10.1371/journal.pone.0100995  0.4
2014 Stein AP, Saha S, Yu M, Kimple RJ, Lambert PF. Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in the United States across time. Chemical Research in Toxicology. 27: 462-9. PMID 24641254 DOI: 10.1021/tx500034c  0.4
2014 Blitzer GC, Smith MA, Harris SL, Kimple RJ. Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck. International Journal of Radiation Oncology, Biology, Physics. 88: 761-70. PMID 24606845 DOI: 10.1016/j.ijrobp.2013.08.029  0.4
2014 Fowler TL, Fulkerson RK, Micka JA, Kimple RJ, Bednarz BP. A novel high-throughput irradiator for in vitro radiation sensitivity bioassays. Physics in Medicine and Biology. 59: 1459-70. PMID 24584120 DOI: 10.1088/0031-9155/59/6/1459  0.4
2013 Kimple RJ, Smith MA, Blitzer GC, Torres AD, Martin JA, Yang RZ, Peet CR, Lorenz LD, Nickel KP, Klingelhutz AJ, Lambert PF, Harari PM. Enhanced radiation sensitivity in HPV-positive head and neck cancer. Cancer Research. 73: 4791-800. PMID 23749640 DOI: 10.1158/0008-5472.CAN-13-0587  0.4
2013 Apisarnthanarax S, Swisher-McClure S, Chiu WK, Kimple RJ, Harris SL, Morris DE, Tepper JE. Applicability of randomized trials in radiation oncology to standard clinical practice. Cancer. 119: 3092-9. PMID 23674290 DOI: 10.1002/cncr.28149  0.4
2013 Vanderwalde NA, Jones EL, Kimple RJ, Moore DT, Klauber-Demore N, Sartor CI, Ollila DW. Phase 2 study of pre-excision single-dose intraoperative radiation therapy for early-stage breast cancers: six-year update with application of the ASTRO accelerated partial breast irradiation consensus statement criteria. Cancer. 119: 1736-43. PMID 23361892 DOI: 10.1002/cncr.27915  0.4
2013 Kimple RJ, Harari PM, Torres AD, Yang RZ, Soriano BJ, Yu M, Armstrong EA, Blitzer GC, Smith MA, Lorenz LD, Lee D, Yang DT, McCulloch TM, Hartig GK, Lambert PF. Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 855-64. PMID 23251001 DOI: 10.1158/1078-0432.CCR-12-2746  0.4
2013 Kimple RJ, Kao GD. A 10-year analysis of American Society For Radiation Oncology Junior Faculty Career Development Awards. International Journal of Radiation Oncology, Biology, Physics. 85: 924-8. PMID 22929862 DOI: 10.1016/j.ijrobp.2012.07.2361  0.4
2012 Kimple RJ, Horton JK, Livasy CA, Shields JM, Lawrence JA, Chiu WM, Ivanova A, Ollila DW, Carey LA, Halle JS, Sartor CI, Dees EC. Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer. The Oncologist. 17: 1496-503. PMID 23006498 DOI: 10.1634/theoncologist.2012-0256  0.4
2012 Kimple AJ, Torres AD, Yang RZ, Kimple RJ. HPV-associated head and neck cancer: molecular and nano-scale markers for prognosis and therapeutic stratification. Sensors (Basel, Switzerland). 12: 5159-69. PMID 22666080 DOI: 10.3390/s120405159  0.44
2011 Kimple RJ, Wallen KE, Person T, Erwin RN, Helmrath MA, Gold S, Morris DE. First use of electromagnetic setup and real-time tracking in a pediatric patient with vaginal rhabdomyosarcoma. Practical Radiation Oncology. 1: 47-51. PMID 24673871 DOI: 10.1016/j.prro.2010.08.001  0.4
2011 Harris SL, Thorne LB, Seaman WT, Hayes DN, Couch ME, Kimple RJ. Association of p16(INK4a) overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue. Head & Neck. 33: 1622-7. PMID 21990227 DOI: 10.1002/hed.21650  0.4
2011 Sambade MJ, Peters EC, Thomas NE, Kaufmann WK, Kimple RJ, Shields JM. Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 98: 394-9. PMID 21295875 DOI: 10.1016/j.radonc.2010.12.017  0.4
2011 Kimple RJ, Klauber-DeMore N, Kuzmiak CM, Pavic D, Lian J, Livasy CA, Chiu WM, Moore DT, Sartor CI, Ollila DW. Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer. Annals of Surgical Oncology. 18: 939-45. PMID 21061074 DOI: 10.1245/s10434-010-1392-6  0.4
2011 Kimple RJ, Klauber-DeMore N, Kuzmiak CM, Pavic D, Lian J, Livasy CA, Esler L, Moore DT, Sartor CI, Ollila DW. Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapy. International Journal of Radiation Oncology, Biology, Physics. 79: 400-7. PMID 20395062 DOI: 10.1016/j.ijrobp.2009.10.032  0.4
2010 Sambade MJ, Kimple RJ, Camp JT, Peters E, Livasy CA, Sartor CI, Shields JM. Lapatinib in combination with radiation diminishes tumor regrowth in HER2+ and basal-like/EGFR+ breast tumor xenografts. International Journal of Radiation Oncology, Biology, Physics. 77: 575-81. PMID 20457354 DOI: 10.1016/j.ijrobp.2009.12.063  0.4
2010 Hutsell SQ, Kimple RJ, Siderovski DP, Willard FS, Kimple AJ. High-affinity immobilization of proteins using biotin- and GST-based coupling strategies. Methods in Molecular Biology (Clifton, N.J.). 627: 75-90. PMID 20217614 DOI: 10.1007/978-1-60761-670-2_4  0.72
2010 Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, Sartor CI. Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 912-23. PMID 20103665 DOI: 10.1158/1078-0432.CCR-09-1324  0.4
2010 Harris SL, Kimple RJ, Hayes DN, Couch ME, Rosenman JG. Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers. Head & Neck. 32: 499-503. PMID 19691028 DOI: 10.1002/hed.21220  0.4
2009 Sambade MJ, Camp JT, Kimple RJ, Sartor CI, Shields JM. Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 93: 639-44. PMID 19853943 DOI: 10.1016/j.radonc.2009.09.006  0.4
2009 Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Plos One. 4: e4884. PMID 19319189 DOI: 10.1371/journal.pone.0004884  0.4
2007 Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B. Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. Journal of Molecular Biology. 371: 1392-404. PMID 17603074 DOI: 10.1016/j.jmb.2007.05.096  0.4
2005 McCudden CR, Willard FS, Kimple RJ, Johnston CA, Hains MD, Jones MB, Siderovski DP. G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN. Biochimica Et Biophysica Acta. 1745: 254-64. PMID 15946753 DOI: 10.1016/j.bbamcr.2005.05.002  0.72
2005 Webb CK, McCudden CR, Willard FS, Kimple RJ, Siderovski DP, Oxford GS. D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides. Journal of Neurochemistry. 92: 1408-18. PMID 15748159 DOI: 10.1111/j.1471-4159.2004.02997.x  0.4
2005 McCudden CR, Hains MD, Kimple RJ, Siderovski DP, Willard FS. G-protein signaling: back to the future. Cellular and Molecular Life Sciences : Cmls. 62: 551-77. PMID 15747061 DOI: 10.1007/s00018-004-4462-3  0.72
2004 Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Developmental Cell. 7: 763-9. PMID 15525537 DOI: 10.1016/j.devcel.2004.10.004  0.4
2004 Kimple RJ, Willard FS, Siderovski DP. Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides. Methods in Enzymology. 390: 416-36. PMID 15488192 DOI: 10.1016/S0076-6879(04)90026-2  0.72
2004 Willard FS, Kimple RJ, Kimple AJ, Johnston CA, Siderovski DP. Fluorescence-based assays for RGS box function. Methods in Enzymology. 389: 56-71. PMID 15313559 DOI: 10.1016/S0076-6879(04)89004-9  0.4
2004 Willard FS, Kimple RJ, Siderovski DP. Return of the GDI: the GoLoco motif in cell division. Annual Review of Biochemistry. 73: 925-51. PMID 15189163 DOI: 10.1146/annurev.biochem.73.011303.073756  0.72
2004 Kimple RJ, Willard FS, Hains MD, Jones MB, Nweke GK, Siderovski DP. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. The Biochemical Journal. 378: 801-8. PMID 14656218 DOI: 10.1042/BJ20031686  0.72
2003 Rojas RJ, Kimple RJ, Rossman KL, Siderovski DP, Sondek J. Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Combinatorial Chemistry & High Throughput Screening. 6: 409-18. PMID 12769685  0.4
2003 Kimple RJ, Jones MB, Shutes A, Yerxa BR, Siderovski DP, Willard FS. Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins. Combinatorial Chemistry & High Throughput Screening. 6: 399-407. PMID 12769684  0.72
2003 Colombo K, Grill SW, Kimple RJ, Willard FS, Siderovski DP, Gönczy P. Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science (New York, N.Y.). 300: 1957-61. PMID 12750478 DOI: 10.1126/science.1084146  0.72
2002 Kimple RJ, Willard FS, Siderovski DP. The GoLoco motif: heralding a new tango between G protein signaling and cell division. Molecular Interventions. 2: 88-100. PMID 14993354 DOI: 10.1124/mi.2.2.88  0.72
2002 Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 416: 878-81. PMID 11976690 DOI: 10.1038/416878a  0.4
2001 Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. The Journal of Biological Chemistry. 276: 29275-81. PMID 11387333 DOI: 10.1074/jbc.M103208200  0.4
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