Joseph M. Metzger - Publications

University of Michigan, Ann Arbor, Ann Arbor, MI 
Biomedical Engineering, Animal Physiology Biology, General Biophysics

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Houang EM, Bartos J, Hackel BJ, Lodge TP, Yannopoulos D, Bates FS, Metzger JM. Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury. Jacc. Basic to Translational Science. 4: 275-287. PMID 31061929 DOI: 10.1016/j.jacbts.2019.01.009  0.44
2018 Houang EM, Sham YY, Bates FS, Metzger JM. Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers. Skeletal Muscle. 8: 31. PMID 30305165 DOI: 10.1186/s13395-018-0177-7  0.44
2018 Vetter AD, Houang EM, Sell JJ, Thompson BR, Sham YY, Metzger JM. TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility. Biophysical Journal. 114: 1646-1656. PMID 29642034 DOI: 10.1016/j.bpj.2018.02.015  0.44
2017 Houang EM, Bates FS, Sham YY, Metzger JM. All-Atom Molecular Dynamics-Based Analysis of Membrane Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions. The Journal of Physical Chemistry. B. PMID 29049887 DOI: 10.1021/acs.jpcb.7b08938  0.44
2017 Houang EM, Haman KJ, Kim M, Zhang W, Lowe DA, Sham YY, Lodge TP, Hackel BJ, Bates FS, Metzger JM. Chemical endgroup modified diblock copolymers elucidate anchor and chain mechanism of membrane stabilization. Molecular Pharmaceutics. PMID 28538101 DOI: 10.1021/acs.molpharmaceut.7b00197  0.44
2017 Kim M, Haman KJ, Houang EM, Zhang W, Yannopoulos D, Metzger JM, Bates FS, Hackel BJ. PEO-PPO diblock copolymers protect myoblasts from hypo-osmotic stress in vitro dependent on copolymer size, composition, and architecture. Biomacromolecules. PMID 28535058 DOI: 10.1021/acs.biomac.7b00419  0.44
2016 Bedada FB, Martindale JJ, Arden E, Metzger JM. Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling. Scientific Reports. 6: 36803. PMID 27833092 DOI: 10.1038/srep36803  0.36
2016 Prins KW, Asp ML, Zhang H, Wang W, Metzger JM. Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. Jacc. Basic to Translational Science. 1: 122-130. PMID 27482548 DOI: 10.1016/j.jacbts.2016.02.002  0.44
2016 Thompson BR, Martindale J, Metzger JM. Sarcomere neutralization in inherited cardiomyopathy: Small molecule proof-of-concept to correct hyper-Ca2+ sensitive myofilaments. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00981.2015. PMID 27199134 DOI: 10.1152/ajpheart.00981.2015  0.44
2016 Asp ML, Sjaastad FV, Siddiqui JK, Davis JP, Metzger JM. Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function. Biophysical Journal. 110: 2094-105. PMID 27166817 DOI: 10.1016/j.bpj.2016.03.037  0.44
2016 Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. PMID 27114035 DOI: 10.1016/j.cell.2016.04.002  0.44
2016 Duan D, Rafael-Fortney JA, Blain A, Kass DA, McNally EM, Metzger JM, Spurney CF, Kinnett K. Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy. Journal of Cardiovascular Translational Research. 9: 85-6. PMID 26718928 DOI: 10.1007/s12265-015-9669-6  0.44
2015 Houang EM, Haman KJ, Filareto A, Perlingeiro RC, Bates FS, Lowe DA, Metzger JM. Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo. Molecular Therapy. Methods & Clinical Development. 2: 15042. PMID 26623440 DOI: 10.1038/mtm.2015.42  0.44
2015 Bedada FB, Wheelwright M, Metzger JM. Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes. Biochimica Et Biophysica Acta. PMID 26578113 DOI: 10.1016/j.bbamcr.2015.11.005  0.44
2015 Cui W, Jang A, Zhang P, Thompson B, Townsend D, Metzger JM, Zhang J. Early Detection of Myocardial Bioenergetic Deficits: A 9.4 Tesla Complete Non Invasive 31P MR Spectroscopy Study in Mice with Muscular Dystrophy. Plos One. 10: e0135000. PMID 26262993 DOI: 10.1371/journal.pone.0135000  0.44
2015 Barnabei MS, Sjaastad FV, Townsend D, Bedada FB, Metzger JM. Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment. Science Translational Medicine. 7: 294ra106. PMID 26136477 DOI: 10.1126/scitranslmed.aaa4804  0.44
2015 Heinis FI, Vermillion KL, Andrews MT, Metzger JM. Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R368-77. PMID 26017496 DOI: 10.1152/ajpregu.00365.2014  0.44
2015 McNally EM, Kaltman JR, Benson DW, Canter CE, Cripe LH, Duan D, Finder JD, Hoffman EP, Judge DP, Kertesz N, Kinnett K, Kirsch R, Metzger JM, Pearson GD, Rafael-Fortney JA, et al. Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy. Circulation. 131: 1590-8. PMID 25940966 DOI: 10.1161/CIRCULATIONAHA.114.015151  0.44
2015 Bartos JA, Matsuura TR, Sarraf M, Youngquist ST, McKnite SH, Rees JN, Sloper DT, Bates FS, Segal N, Debaty G, Lurie KG, Neumar RW, Metzger JM, Riess ML, Yannopoulos D. Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest. Resuscitation. 87: 7-13. PMID 25447036 DOI: 10.1016/j.resuscitation.2014.10.019  0.44
2014 Bedada FB, Chan SS, Metzger SK, Zhang L, Zhang J, Garry DJ, Kamp TJ, Kyba M, Metzger JM. Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes. Stem Cell Reports. 3: 594-605. PMID 25358788 DOI: 10.1016/j.stemcr.2014.07.012  0.44
2014 Thompson BR, Metzger JM. Cell biology of sarcomeric protein engineering: disease modeling and therapeutic potential. Anatomical Record (Hoboken, N.J. : 2007). 297: 1663-9. PMID 25125179 DOI: 10.1002/ar.22966  0.44
2014 Thompson BR, Houang EM, Sham YY, Metzger JM. Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues. Biophysical Journal. 106: 2105-14. PMID 24853739 DOI: 10.1016/j.bpj.2014.04.017  0.44
2014 Wang W, Asp ML, Guerrero-Serna G, Metzger JM. Differential effects of S100 proteins A2 and A6 on cardiac Ca(2+) cycling and contractile performance. Journal of Molecular and Cellular Cardiology. 72: 117-25. PMID 24631772 DOI: 10.1016/j.yjmcc.2014.03.003  0.44
2014 Martindale JJ, Metzger JM. Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization. Journal of Molecular and Cellular Cardiology. 67: 26-37. PMID 24362314 DOI: 10.1016/j.yjmcc.2013.12.008  0.44
2013 Wang W, Barnabei MS, Asp ML, Heinis FI, Arden E, Davis J, Braunlin E, Li Q, Davis JP, Potter JD, Metzger JM. Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance. Nature Medicine. 19: 305-12. PMID 23396207 DOI: 10.1038/nm.3079  0.44
2013 Asp ML, Martindale JJ, Heinis FI, Wang W, Metzger JM. Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies. Biochimica Et Biophysica Acta. 1833: 895-900. PMID 23022395 DOI: 10.1016/j.bbamcr.2012.09.007  0.44
2012 Davis J, Yasuda S, Palpant NJ, Martindale J, Stevenson T, Converso K, Metzger JM. Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy. Journal of Molecular and Cellular Cardiology. 53: 446-57. PMID 22683325 DOI: 10.1016/j.yjmcc.2012.05.018  0.44
2012 Palpant NJ, Houang EM, Sham YY, Metzger JM. pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I. Biophysical Journal. 102: 1570-9. PMID 22500757 DOI: 10.1016/j.bpj.2012.01.024  0.44
2012 Barnabei MS, Metzger JM. Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts. Plos One. 7: e32880. PMID 22427904 DOI: 10.1371/journal.pone.0032880  0.44
2011 Barnabei MS, Martindale JM, Townsend D, Metzger JM. Exercise and muscular dystrophy: implications and analysis of effects on musculoskeletal and cardiovascular systems. Comprehensive Physiology. 1: 1353-63. PMID 23733645 DOI: 10.1002/cphy.c100062  0.44
2011 Rasmussen TL, Kweon J, Diekmann MA, Belema-Bedada F, Song Q, Bowlin K, Shi X, Ferdous A, Li T, Kyba M, Metzger JM, Koyano-Nakagawa N, Garry DJ. ER71 directs mesodermal fate decisions during embryogenesis. Development (Cambridge, England). 138: 4801-12. PMID 21989919 DOI: 10.1242/dev.070912  0.44
2011 Townsend D, Daly M, Chamberlain JS, Metzger JM. Age-dependent dystrophin loss and genetic reconstitution establish a molecular link between dystrophin and heart performance during aging. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1821-5. PMID 21730971 DOI: 10.1038/mt.2011.120  0.44
2011 Townsend D, Yasuda S, McNally E, Metzger JM. Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3106-14. PMID 21665956 DOI: 10.1096/fj.10-178913  0.56
2011 Palpant NJ, Bedada FB, Peacock B, Blazar BR, Metzger JM, Tolar J. Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies American Journal of Physiology - Heart and Circulatory Physiology. 300: H356-H365. PMID 21076027 DOI: 10.1152/ajpheart.00774.2010  0.44
2010 Barnabei MS, Palpant NJ, Metzger JM. Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains. Physiological Genomics. 42: 103-13. PMID 20627938 DOI: 10.1152/physiolgenomics.00071.2010  0.44
2010 Palpant NJ, Houang EM, Delport W, Hastings KE, Onufriev AV, Sham YY, Metzger JM. Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations. Physiological Genomics. 42: 287-99. PMID 20423961 DOI: 10.1152/physiolgenomics.00033.2010  0.44
2010 Townsend D, Turner I, Yasuda S, Martindale J, Davis J, Shillingford M, Kornegay JN, Metzger JM. Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs. The Journal of Clinical Investigation. 120: 1140-50. PMID 20234088 DOI: 10.1172/JCI41329  0.56
2010 Palpant NJ, Metzger JM. Aesthetic cardiology: adipose-derived stem cells for myocardial repair. Current Stem Cell Research & Therapy. 5: 145-52. PMID 19941452  0.8
2010 Herron TJ, Devaney E, Mundada L, Arden E, Day S, Guerrero-Serna G, Turner I, Westfall M, Metzger JM. Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by alpha-myosin motor gene transfer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 415-24. PMID 19801488 DOI: 10.1096/fj.09-140566  0.44
2009 Wang W, Martindale J, Metzger JM. Parvalbumin: Targeting calcium handling in cardiac diastolic dysfunction. General Physiology and Biophysics. 28: F3-6. PMID 20093724  0.44
2009 Townsend D, Yasuda S, Chamberlain J, Metzger JM. Cardiac consequences to skeletal muscle-centric therapeutics for Duchenne muscular dystrophy. Trends in Cardiovascular Medicine. 19: 50-55. PMID 19577712 DOI: 10.1016/j.tcm.2009.04.006  0.44
2009 Palpant NJ, Szatkowski ML, Wang W, Townsend D, Bedada FB, Koch LG, Britton SL, Metzger JM. Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure. Plos One. 4: e6117. PMID 19568432 DOI: 10.1371/journal.pone.0006117  0.8
2009 Palpant NJ, D'Alecy LG, Metzger JM. Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1529-40. PMID 19141534 DOI: 10.1096/fj.08-121996  0.8
2008 Russell MW, Townsend D, Metzger JM. Cardiac involvement in the dystrophinopathies. Journal of Pediatric Rehabilitation Medicine. 1: 211-23. PMID 21791770  0.44
2008 Turner I, Belema-Bedada F, Martindale J, Townsend D, Wang W, Palpant N, Yasuda SC, Barnabei M, Fomicheva E, Metzger JM. Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart. Journal of Cardiovascular Translational Research. 1: 317-27. PMID 19956787 DOI: 10.1007/s12265-008-9065-6  0.44
2008 Davis J, Westfall MV, Townsend D, Blankinship M, Herron TJ, Guerrero-Serna G, Wang W, Devaney E, Metzger JM. Designing heart performance by gene transfer. Physiological Reviews. 88: 1567-651. PMID 18923190 DOI: 10.1152/physrev.00039.2007  0.44
2008 Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM. Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction. Cardiovascular Research. 80: 209-18. PMID 18635554 DOI: 10.1093/cvr/cvn198  0.44
2008 Fomicheva EV, Turner II, Edwards TG, Hoff J, Arden E, D'Alecy LG, Metzger JM. Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1594-601. PMID 18578010 DOI: 10.1038/mt.2008.136  0.44
2008 Ng R, Metzger JM, Claflin DR, Faulkner JA. Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice. American Journal of Physiology. Cell Physiology. 295: C146-50. PMID 18495816 DOI: 10.1152/ajpcell.00017.2008  0.44
2008 Wang W, Metzger JM. Parvalbumin isoforms for enhancing cardiac diastolic function. Cell Biochemistry and Biophysics. 51: 1-8. PMID 18458829 DOI: 10.1007/s12013-008-9011-x  0.44
2008 Townsend D, Yasuda S, Li S, Chamberlain JS, Metzger JM. Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 832-5. PMID 18414480 DOI: 10.1038/mt.2008.52  0.44
2008 Herron TJ, Devaney EJ, Metzger JM. Modulation of cardiac performance by motor protein gene transfer. Annals of the New York Academy of Sciences. 1123: 96-104. PMID 18375581 DOI: 10.1196/annals.1420.011  0.44
2008 Day SM, Coutu P, Wang W, Herron T, Turner I, Shillingford M, Lacross NC, Converso KL, Piao L, Li J, Lopatin AN, Metzger JM. Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca2+ buffering action. Physiological Genomics. 33: 312-22. PMID 18334547 DOI: 10.1152/physiolgenomics.00302.2007  0.44
2007 Palpant NJ, Yasuda S, MacDougald O, Metzger JM. Non-canonical Wnt signaling enhances differentiation of Sca1+/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes. Journal of Molecular and Cellular Cardiology. 43: 362-70. PMID 17706246 DOI: 10.1016/j.yjmcc.2007.06.012  0.8
2007 Yasuda S, Coutu P, Sadayappan S, Robbins J, Metzger JM. Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circulation Research. 101: 377-86. PMID 17615373 DOI: 10.1161/CIRCRESAHA.106.145557  0.96
2007 Westfall MV, Metzger JM. Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity. Journal of Molecular and Cellular Cardiology. 43: 107-18. PMID 17602701 DOI: 10.1016/j.yjmcc.2007.05.017  0.32
2007 Rodenbaugh DW, Wang W, Davis J, Edwards T, Potter JD, Metzger JM. Parvalbumin isoforms differentially accelerate cardiac myocyte relaxation kinetics in an animal model of diastolic dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. 293: H1705-13. PMID 17545482 DOI: 10.1152/ajpheart.00232.2007  0.44
2007 Townsend D, Blankinship MJ, Allen JM, Gregorevic P, Chamberlain JS, Metzger JM. Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1086-92. PMID 17440445 DOI: 10.1038/  0.44
2007 Day SM, Westfall MV, Metzger JM. Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function. Journal of Molecular Medicine (Berlin, Germany). 85: 911-21. PMID 17396243 DOI: 10.1007/s00109-007-0181-6  0.44
2007 Herron TJ, Vandenboom R, Fomicheva E, Mundada L, Edwards T, Metzger JM. Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes. Circulation Research. 100: 1182-90. PMID 17363698 DOI: 10.1161/01.RES.0000264102.00706.4e  0.44
2007 Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proceedings of the National Academy of Sciences of the United States of America. 104: 3943-8. PMID 17360457 DOI: 10.1073/pnas.0609278104  0.44
2006 Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM. Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nature Medicine. 12: 181-9. PMID 16429145 DOI: 10.1038/nm1346  0.44
2005 Yasuda S, Townsend D, Michele DE, Favre EG, Day SM, Metzger JM. Dystrophic heart failure blocked by membrane sealant poloxamer. Nature. 436: 1025-9. PMID 16025101 DOI: 10.1038/nature03844  0.44
2005 Coutu P, Metzger JM. Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies. American Journal of Physiology. Heart and Circulatory Physiology. 288: H601-12. PMID 15331372 DOI: 10.1152/ajpheart.00424.2004  0.96
2005 Coutu P, Metzger JM. Genetic manipulation of calcium-handling proteins in cardiac myocytes. II. Mathematical modeling studies. American Journal of Physiology. Heart and Circulatory Physiology. 288: H613-31. PMID 15331371 DOI: 10.1152/ajpheart.00425.2004  0.96
2004 Michele DE, Szatkowski ML, Albayya FP, Metzger JM. Parvalbumin gene delivery improves diastolic function in the aged myocardium in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 399-403. PMID 15294186 DOI: 10.1016/j.ymthe.2004.05.011  0.44
2004 Hirsch JC, Borton AR, Albayya FP, Russell MW, Ohye RG, Metzger JM. Comparative analysis of parvalbumin and SERCA2a cardiac myocyte gene transfer in a large animal model of diastolic dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. 286: H2314-21. PMID 15148059 DOI: 10.1152/ajpheart.01137.2003  0.44
2004 Coutu P, Bennett CN, Favre EG, Day SM, Metzger JM. Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations. Circulation Research. 94: 1235-41. PMID 15059934 DOI: 10.1161/01.RES.0000126923.46786.FD  0.44
2004 Metzger JM, Westfall MV. Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation. Circulation Research. 94: 146-58. PMID 14764650 DOI: 10.1161/01.RES.0000110083.17024.60  0.32
2003 Westfall MV, Metzger JM. Gene transfer of troponin I isoforms, mutants, and chimeras. Advances in Experimental Medicine and Biology. 538: 169-74; discussion 1. PMID 15098664  0.32
2003 Szatkowski ML, Westfall MV, Metzger JM. Direct gene transfer to the adult rodent myocardium in vivo. Methods in Molecular Biology (Clifton, N.J.). 219: 195-202. PMID 12597009  0.36
2003 Hirsch JC, Borton AR, Metzger JM. Isolation, culture, and gene transfer of adult canine cardiac myocytes. Methods in Molecular Biology (Clifton, N.J.). 219: 145-57. PMID 12597005  0.44
2003 Coutu P, Hirsch JC, Szatkowski ML, Metzger JM. Targeting diastolic dysfunction by genetic engineering of calcium handling proteins. Trends in Cardiovascular Medicine. 13: 63-7. PMID 12586441 DOI: 10.1016/S1050-1738(02)00213-X  0.44
2003 Metzger JM, Michele DE, Rust EM, Borton AR, Westfall MV. Sarcomere thin filament regulatory isoforms. Evidence of a dominant effect of slow skeletal troponin I on cardiac contraction. The Journal of Biological Chemistry. 278: 13118-23. PMID 12551900 DOI: 10.1074/jbc.M212601200  0.44
2002 Westfall MV, Borton AR, Albayya FP, Metzger JM. Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants. Circulation Research. 91: 525-31. PMID 12242271  0.32
2002 Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM. Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Circulation Research. 91: 255-62. PMID 12169652 DOI: 10.1161/01.RES.0000027530.58419.82  0.44
2002 Michele DE, Coutu P, Metzger JM. Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. Physiological Genomics. 9: 103-11. PMID 12006676 DOI: 10.1152/physiolgenomics.00099.2001  0.44
2002 Coutu P, Metzger JM. Optimal range for parvalbumin as relaxing agent in adult cardiac myocytes: gene transfer and mathematical modeling. Biophysical Journal. 82: 2565-79. PMID 11964244 DOI: 10.1016/S0006-3495(02)75599-9  0.96
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