Jay S. Desgrosellier, Ph.D. - Publications

Affiliations: 
2004 Vanderbilt University, Nashville, TN 
Area:
Pharmacology, Animal Physiology Biology

29/35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sun Q, Wang Y, Officer A, Harismendy O, Desgrosellier JS. Abstract 6024: An integrin αvβ3+ stem-like tumor cell subset promotes breast cancer progression via c-Jun/AXL signaling Cancer Research. 80: 6024-6024. DOI: 10.1158/1538-7445.Am2020-6024  0.458
2019 Sun Q, Wang Y, Desgrosellier JS. Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells. Cancer Letters. PMID 31078737 DOI: 10.1016/J.Canlet.2019.05.004  0.384
2018 Sun Q, Lesperance J, Wettersten H, Luterstein E, DeRose YS, Welm A, Cheresh DA, Desgrosellier JS. Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. The Journal of Clinical Investigation. 128: 531-544. PMID 29227280 DOI: 10.1172/Jci93707  0.453
2017 Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier JS, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. Galectin-3, a druggable vulnerability for KRAS-addicted cancers. Cancer Discovery. PMID 28893801 DOI: 10.1158/2159-8290.Cd-17-0539  0.408
2016 Sun Q, Lesperance J, Desgrosellier JS. Abstract 3321: PUMA expression targets αvβ3/Slug+ “stem-like” tumor cells to prevent breast cancer progression independent of subtype Cancer Research. 76: 3321-3321. DOI: 10.1158/1538-7445.Am2016-3321  0.426
2015 Seguin L, Desgrosellier JS, Weis SM, Cheresh DA. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends in Cell Biology. 25: 234-40. PMID 25572304 DOI: 10.1016/J.Tcb.2014.12.006  0.478
2014 Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Developmental Cell. 30: 295-308. PMID 25117682 DOI: 10.1016/J.Devcel.2014.06.005  0.469
2014 Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, ... ... Desgrosellier JS, et al. An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nature Cell Biology. 16: 457-68. PMID 24747441 DOI: 10.1038/Ncb2953  0.391
2014 Kato S, Seguin L, Franovic A, Kato H, Camargo M, Desgrosellier J, Anand S, Weis S, Shattil S, Cheresh DA. Abstract 4240: Targeting Galectin-3 to reverse tumor stemness and drug resistance Cancer Research. 74: 4240-4240. DOI: 10.1158/1538-7445.Am2014-4240  0.403
2014 Desgrosellier JS, Lesperance J, Seguin L, Shattil SJ, Cheresh DA. Abstract 3034: Integrin αvβ3 drives Slug activation and stemness in the pregnant and neoplastic mammary gland Cancer Research. 74: 3034-3034. DOI: 10.1158/1538-7445.Am2014-3034  0.425
2014 Seguin LJ, Kato S, Franovic A, Camargo MF, Elliott K, Yebra M, Lesperance J, Mielgo A, Desgrosellier J, Anand S, Weis S, Cheresh D. Abstract 1916: β3 integrin/KRAS/RalB complex drives tumor stemness and resistance to EGFR inhibition Cancer Research. 74: 1916-1916. DOI: 10.1158/1538-7445.Am2014-1916  0.422
2013 Desgrosellier J, Lesperance J, Seguin L, Shattil S, Cheresh D. Abstract A036: Integrin αvβ3 drives the mammary stem cell state during pregnancy Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A036  0.412
2013 Desgrosellier J, Lesperance J, Seguin L, Cheresh D. Abstract C78: Integrin αvβ3 drives stemness in the pregnant and neoplastic mammary gland Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C78  0.389
2012 Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. Plos One. 7: e36753. PMID 22586492 DOI: 10.1371/Journal.Pone.0036753  0.477
2012 Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 31: 2783-93. PMID 21963850 DOI: 10.1038/Onc.2011.450  0.473
2012 Seguin LJ, Mielgo A, Huang M, Camargo FC, Lesperance J, Weis SM, Desgrosellier JS, Cheresh DA. Abstract LB-344: Emergence of carcinoma resistance to EGFR blockade via an integrin avb3/RalB/NFkB signaling axis Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-344  0.433
2011 Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA. Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene. 30: 2123-34. PMID 21242978 DOI: 10.1038/Onc.2010.589  0.392
2011 Acevedo LM, Desgrosellier J, Cheresh DA. Abstract 1474: Semaphorin 3A potentiates metastatic disease by binding to endothelial Neuropilin-1 and disrupting vascular barrier function Cancer Research. 71: 1474-1474. DOI: 10.1158/1538-7445.Am2011-1474  0.435
2010 Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 107: 2189-94. PMID 20080647 DOI: 10.1073/Pnas.0911646107  0.473
2010 Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nature Reviews. Cancer. 10: 9-22. PMID 20029421 DOI: 10.1038/Nrc2748  0.392
2010 Desgrosellier JS, Seguin L, Barnes LA, Shields DJ, Huang M, Lau SK, Prevost N, Tarin D, Shattil SJ, Cheresh DA. Abstract 3841: An integrin αvβ3/c-Src oncogenic unit promotes anchorage independence and tumor progression Cancer Research. 70: 3841-3841. DOI: 10.1158/1538-7445.Am10-3841  0.43
2010 Desgrosellier JS, Cheresh DA. Erratum: Integrins in cancer: biological implications and therapeutic opportunities Nature Reviews Cancer. 10: 890-890. DOI: 10.1038/Nrc2965  0.341
2009 Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nature Medicine. 15: 1163-9. PMID 19734908 DOI: 10.1038/Nm.2009  0.416
2006 Park HJ, Ward SM, Desgrosellier JS, Georgescu SP, Papageorge AG, Zhuang X, Barnett JV, Galper JB. Transforming growth factor beta regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP. The Journal of Biological Chemistry. 281: 19995-20002. PMID 16707504 DOI: 10.1074/Jbc.M513095200  0.679
2005 Desgrosellier JS, Mundell NA, McDonnell MA, Moses HL, Barnett JV. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Developmental Biology. 280: 201-10. PMID 15766759 DOI: 10.1016/J.Ydbio.2004.12.037  0.646
2003 Barnett JV, Desgrosellier JS. Early events in valvulogenesis: a signaling perspective. Birth Defects Research. Part C, Embryo Today : Reviews. 69: 58-72. PMID 12768658 DOI: 10.1002/Bdrc.10006  0.596
2002 Ward SM, Desgrosellier JS, Zhuang X, Barnett JV, Galper JB. Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. The Journal of Biological Chemistry. 277: 50183-9. PMID 12393881 DOI: 10.1074/jbc.M209668200  0.676
2002 Russo J, Barnes A, Berger K, Desgrosellier J, Henderson J, Kanters A, Merkov L. 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal Bmc Pharmacology. 2: 4-4. PMID 11872149 DOI: 10.1186/1471-2210-2-4  0.346
2000 Lai YT, Beason KB, Brames GP, Desgrosellier JS, Cleggett MC, Shaw MV, Brown CB, Barnett JV. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Developmental Biology. 222: 1-11. PMID 10885742 DOI: 10.1006/Dbio.2000.9698  0.679
Low-probability matches (unlikely to be authored by this person)
2013 Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proceedings of the National Academy of Sciences of the United States of America. 110: 9042-7. PMID 23671068 DOI: 10.1073/Pnas.1219603110  0.279
2023 Baba SA, Sun Q, Mugisha S, Labhsetwar S, Klemke R, Desgrosellier JS. Breast cancer stem cells tolerate chromosomal instability during tumor progression via c-Jun/AXL stress signaling. Heliyon. 9: e20182. PMID 37809421 DOI: 10.1016/j.heliyon.2023.e20182  0.268
1999 Ayala JE, Streeper RS, Desgrosellier JS, Durham SK, Suwanichkul A, Svitek CA, Goldman JK, Barr FG, Powell DR, O'Brien RM. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence. Diabetes. 48: 1885-9. PMID 10480625 DOI: 10.2337/Diabetes.48.9.1885  0.259
2023 Baba SA, Labhsetwar S, Klemke R, Desgrosellier JS. A dataset of chromosomal instability gene signature scores in normal and cancer cells from the human breast. Data in Brief. 51: 109647. PMID 37840990 DOI: 10.1016/j.dib.2023.109647  0.229
2022 Sun Q, Wang Y, Officer A, Pecknold B, Lee G, Harismendy O, Desgrosellier JS. Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1. Npj Breast Cancer. 8: 5. PMID 35027548 DOI: 10.1038/s41523-021-00375-w  0.173
2021 Desgrosellier JS. A precision approach to breast cancer treatment based on cell lineage-specific vulnerabilities. Oncoscience. 8: 76-79. PMID 34124284 DOI: 10.18632/oncoscience.538  0.15
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