Francisco Asturias - Publications

Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Cell Biology, General Biophysics

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/Elife.31502  0.64
2017 Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ. Mediator structure and rearrangements required for holoenzyme formation. Nature. PMID 28241144 DOI: 10.1038/nature21393  0.64
2016 Sato S, Tomomori-Sato C, Tsai KL, Yu X, Sardiu M, Saraf A, Washburn MP, Florens L, Asturias FJ, Conaway RC, Conaway JW. Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme. The Journal of Biological Chemistry. PMID 27821593 DOI: 10.1074/jbc.M116.756098  0.64
2016 Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL. Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry. PMID 26727048 DOI: 10.1021/Acs.Biochem.5B01207  1
2015 Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD. Structure of an RNA polymerase II preinitiation complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 13543-8. PMID 26483468 DOI: 10.1073/pnas.1518255112  1
2014 Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ. Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex. Cell. 158: 463. PMID 28915369 DOI: 10.1016/j.cell.2014.06.036  0.64
2014 Lai YT, Reading E, Hura GL, Tsai KL, Laganowsky A, Asturias FJ, Tainer JA, Robinson CV, Yeates TO. Structure of a designed protein cage that self-assembles into a highly porous cube. Nature Chemistry. 6: 1065-71. PMID 25411884 DOI: 10.1038/nchem.2107  1
2014 Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ. Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. Cell. 157: 1430-44. PMID 24882805 DOI: 10.1016/j.cell.2014.05.015  1
2013 Lai YT, Tsai KL, Sawaya MR, Asturias FJ, Yeates TO. Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. Journal of the American Chemical Society. 135: 7738-43. PMID 23621606 DOI: 10.1021/Ja402277F  1
2013 Tsai KL, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, Asturias FJ. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. Nature Structural & Molecular Biology. 20: 611-9. PMID 23563140 DOI: 10.1038/nsmb.2549  1
2013 Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 110: 3835-40. PMID 23431160 DOI: 10.1073/Pnas.1220691110  1
2012 Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/J.Chembiol.2012.05.015  1
2012 Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure (London, England : 1993). 20: 1374-83. PMID 22727814 DOI: 10.1016/J.Str.2012.05.009  1
2012 Cai G, Chaban YL, Imasaki T, Kovacs JA, Calero G, Penczek PA, Takagi Y, Asturias FJ. Interaction of the mediator head module with RNA polymerase II. Structure (London, England : 1993). 20: 899-910. PMID 22579255 DOI: 10.1016/j.str.2012.02.023  1
2012 Gibbons BJ, Brignole EJ, Azubel M, Murakami K, Voss NR, Bushnell DA, Asturias FJ, Kornberg RD. Subunit architecture of general transcription factor TFIIH. Proceedings of the National Academy of Sciences of the United States of America. 109: 1949-54. PMID 22308316 DOI: 10.1073/Pnas.1105266109  1
2011 Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 108: 21046-51. PMID 22160671 DOI: 10.1073/Pnas.1112715108  1
2011 Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, et al. A soluble α-synuclein construct forms a dynamic tetramer. Proceedings of the National Academy of Sciences of the United States of America. 108: 17797-802. PMID 22006323 DOI: 10.1073/Pnas.1113260108  1
2011 Chittuluru JR, Chaban Y, Monnet-Saksouk J, Carrozza MJ, Sapountzi V, Selleck W, Huang J, Utley RT, Cramet M, Allard S, Cai G, Workman JL, Fried MG, Tan S, Côté J, ... Asturias FJ, et al. Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes. Nature Structural & Molecular Biology. 18: 1196-203. PMID 21984211 DOI: 10.1038/Nsmb.2128  1
2011 Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Architecture of the Mediator head module. Nature. 475: 240-3. PMID 21725323 DOI: 10.1038/nature10162  1
2010 Brignole EJ, Asturias F. Single-particle electron microscopy of animal fatty acid synthase describing macromolecular rearrangements that enable catalysis. Methods in Enzymology. 483: 179-202. PMID 20888475 DOI: 10.1016/S0076-6879(10)83009-5  1
2010 Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A. A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes. Molecular and Cellular Biology. 30: 5502-13. PMID 20876299 DOI: 10.1128/MCB.00966-10  1
2010 Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA. Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. Plos Biology. 8. PMID 20856905 DOI: 10.1371/Journal.Pbio.1000483  1
2010 Cai G, Imasaki T, Yamada K, Cardelli F, Takagi Y, Asturias FJ. Mediator head module structure and functional interactions. Nature Structural & Molecular Biology. 17: 273-9. PMID 20154708 DOI: 10.1038/nsmb.1757  0.64
2009 Cai G, Imasaki T, Takagi Y, Asturias FJ. Mediator structural conservation and implications for the regulation mechanism. Structure (London, England : 1993). 17: 559-67. PMID 19368889 DOI: 10.1016/j.str.2009.01.016  0.64
2009 Brignole EJ, Smith S, Asturias FJ. Conformational flexibility of metazoan fatty acid synthase enables catalysis. Nature Structural & Molecular Biology. 16: 190-7. PMID 19151726 DOI: 10.1038/nsmb.1532  1
2008 Shaikh TR, Gao H, Baxter WT, Asturias FJ, Boisset N, Leith A, Frank J. SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nature Protocols. 3: 1941-74. PMID 19180078 DOI: 10.1038/Nprot.2008.156  1
2008 Chaban Y, Ezeokonkwo C, Chung WH, Zhang F, Kornberg RD, Maier-Davis B, Lorch Y, Asturias FJ. Structure of a RSC-nucleosome complex and insights into chromatin remodeling. Nature Structural & Molecular Biology. 15: 1272-7. PMID 19029894 DOI: 10.1038/nsmb.1524  1
2007 Yang C, Penczek PA, Leith A, Asturias FJ, Ng EG, Glaeser RM, Frank J. The parallelization of SPIDER on distributed-memory computers using MPI Journal of Structural Biology. 157: 240-249. PMID 16859923 DOI: 10.1016/J.Jsb.2006.05.011  1
2006 Takagi Y, Calero G, Komori H, Brown JA, Ehrensberger AH, Hudmon A, Asturias F, Kornberg RD. Head module control of mediator interactions. Molecular Cell. 23: 355-64. PMID 16885025 DOI: 10.1016/j.molcel.2006.06.007  1
2006 Asturias FJ, Cheung IK, Sabouri N, Chilkova O, Wepplo D, Johansson E. Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy. Nature Structural & Molecular Biology. 13: 35-43. PMID 16369485 DOI: 10.1038/nsmb1040  1
2005 Takagi Y, Chadick JZ, Davis JA, Asturias FJ. Preponderance of free mediator in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 31200-7. PMID 16002404 DOI: 10.1074/jbc.C500150200  0.64
2005 Chadick JZ, Asturias FJ. Structure of eukaryotic Mediator complexes. Trends in Biochemical Sciences. 30: 264-71. PMID 15896745 DOI: 10.1016/j.tibs.2005.03.001  0.4
2005 Asturias FJ, Chadick JZ, Cheung IK, Stark H, Witkowski A, Joshi AK, Smith S. Structure and molecular organization of mammalian fatty acid synthase. Nature Structural & Molecular Biology. 12: 225-32. PMID 15711565 DOI: 10.1038/nsmb899  1
2004 Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Molecular Cell. 14: 553-7. PMID 15175151 DOI: 10.1016/J.Molcel.2004.05.011  1
2004 Asturias FJ, Ezeokonkwo C, Kornberg RD, Lorch Y. Electron microscopic analysis of the RSC chromatin remodeling complex. Methods in Enzymology. 376: 48-62. PMID 14975298 DOI: 10.1016/S0076-6879(03)76004-2  1
2003 Chung WH, Craighead JL, Chang WH, Ezeokonkwo C, Bareket-Samish A, Kornberg RD, Asturias FJ. RNA polymerase II/TFIIF structure and conserved organization of the initiation complex. Molecular Cell. 12: 1003-13. PMID 14580350 DOI: 10.1016/S1097-2765(03)00387-3  1
2003 Asturias FJ, Craighead JL. RNA polymerase II at initiation. Proceedings of the National Academy of Sciences of the United States of America. 100: 6893-5. PMID 12782794 DOI: 10.1073/pnas.1332606100  1
2002 Asturias FJ, Chung WH, Kornberg RD, Lorch Y. Structural analysis of the RSC chromatin-remodeling complex. Proceedings of the National Academy of Sciences of the United States of America. 99: 13477-80. PMID 12368485 DOI: 10.1073/pnas.162504299  1
2002 Davis JA, Takagi Y, Kornberg RD, Asturias FA. Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Molecular Cell. 10: 409-15. PMID 12191485 DOI: 10.1016/S1097-2765(02)00598-1  1
2002 Craighead JL, Chang WH, Asturias FJ. Structure of yeast RNA polymerase II in solution: implications for enzyme regulation and interaction with promoter DNA. Structure (London, England : 1993). 10: 1117-25. PMID 12176389 DOI: 10.1016/S0969-2126(02)00813-4  1
2000 Dotson MR, Yuan CX, Roeder RG, Myers LC, Gustafsson CM, Jiang YW, Li Y, Kornberg RD, Asturias FJ. Structural organization of yeast and mammalian mediator complexes. Proceedings of the National Academy of Sciences of the United States of America. 97: 14307-10. PMID 11114191 DOI: 10.1073/pnas.260489497  1
1999 Asturias FJ, Kornberg RD. Protein crystallization on lipid layers and structure determination of the RNA polymerase II transcription initiation complex. The Journal of Biological Chemistry. 274: 6813-6. PMID 10066729 DOI: 10.1074/jbc.274.11.6813  1
1999 Asturias FJ, Jiang YW, Myers LC, Gustafsson CM, Kornberg RD. Conserved structures of mediator and RNA polymerase II holoenzyme. Science (New York, N.Y.). 283: 985-7. PMID 9974391 DOI: 10.1126/science.283.5404.985  1
1998 Asturias FJ, Chang W, Li Y, Kornberg RD. Electron crystallography of yeast RNA polymerase II preserved in vitreous ice. Ultramicroscopy. 70: 133-43. PMID 9499590 DOI: 10.1016/S0304-3991(97)00108-3  1
1997 Edwards AM, Darst SA, Hemming SA, Asturias FJ, David PR, Kornberg RD. [11] Two-dimensional protein crystals in aid of three-dimensional protein crystal growth. Methods in Enzymology. 276: 166-171. PMID 27799092 DOI: 10.1016/S0076-6879(97)76057-9  1
1997 Asturias FJ, Meredith GD, Poglitsch CL, Kornberg RD. Two conformations of RNA polymerase II revealed by electron crystallography. Journal of Molecular Biology. 272: 536-40. PMID 9325110 DOI: 10.1006/jmbi.1997.1273  1
1995 Asturias FJ, Kornberg RD. A novel method for transfer of two-dimensional crystals from the air/water interface to specimen grids. EM sample preparation/lipid-layer crystallization Journal of Structural Biology. 114: 60-66. PMID 7772418 DOI: 10.1006/jsbi.1995.1005  1
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