| Year |
Citation |
Score |
| 2024 |
Menon I, Sych T, Son Y, Morizumi T, Lee J, Ernst OP, Khelashvili G, Sezgin E, Levitz J, Menon AK. A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. The Journal of Biological Chemistry. 105649. PMID 38237683 DOI: 10.1016/j.jbc.2024.105649 |
0.392 |
|
| 2023 |
Menon I, Sych T, Son Y, Morizumi T, Lee J, Ernst OP, Khelashvili G, Sezgin E, Levitz J, Menon AK. A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. Biorxiv : the Preprint Server For Biology. PMID 38045315 DOI: 10.1101/2023.11.24.568580 |
0.392 |
|
| 2023 |
Doktorova M, Khelashvili G, Brown MF. Sampling Bottleneck in Validating Membrane Dynamics. Biorxiv : the Preprint Server For Biology. PMID 37292992 DOI: 10.1101/2023.05.23.542012 |
0.353 |
|
| 2022 |
Doktorova M, Khelashvili G, Ashkar R, Brown MF. Molecular Simulations and NMR Reveal How Lipid Fluctuations Affect Membrane Mechanics. Biophysical Journal. PMID 36474442 DOI: 10.1016/j.bpj.2022.12.007 |
0.443 |
|
| 2022 |
Khelashvili G, Kots E, Cheng X, Levine MV, Weinstein H. The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase. Communications Biology. 5: 990. PMID 36123525 DOI: 10.1038/s42003-022-03930-8 |
0.438 |
|
| 2022 |
Cheng X, Khelashvili G, Weinstein H. The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16. Frontiers in Molecular Biosciences. 9: 903972. PMID 35942471 DOI: 10.3389/fmolb.2022.903972 |
0.36 |
|
| 2022 |
Morra G, Razavi AM, Menon AK, Khelashvili G. Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a G protein-coupled receptor. Structure (London, England : 1993). PMID 35660161 DOI: 10.1016/j.str.2022.05.010 |
0.497 |
|
| 2022 |
Zhang X, Xie H, Iaea D, Khelashvili G, Weinstein H, Maxfield FR. Phosphatidylinositol Phosphates Modulate Interactions between the StarD4 Sterol Trafficking Protein and Lipid Membranes. The Journal of Biological Chemistry. 102058. PMID 35605664 DOI: 10.1016/j.jbc.2022.102058 |
0.484 |
|
| 2021 |
Khelashvili G, Menon AK. Phospholipid Scrambling by G Protein-Coupled Receptors. Annual Review of Biophysics. PMID 34932914 DOI: 10.1146/annurev-biophys-090821-083030 |
0.422 |
|
| 2021 |
Khelashvili G, Pillai AN, Lee J, Pandey K, Payne AM, Siegel Z, Cuendet MA, Lewis TR, Arshavsky VY, Broichhagen J, Levitz J, Menon AK. Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin. Scientific Reports. 11: 10536. PMID 34006992 DOI: 10.1038/s41598-021-90039-3 |
0.379 |
|
| 2021 |
Ashkar R, Doktorova M, Heberle FA, Scott HL, Barrera FN, Katsaras J, Khelashvili G, Brown MF. Reply to Nagle et al.: The universal stiffening effects of cholesterol on lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33952694 DOI: 10.1073/pnas.2102845118 |
0.333 |
|
| 2020 |
Chakraborty S, Doktorova M, Molugu TR, Heberle FA, Scott HL, Dzikovski B, Nagao M, Stingaciu LR, Standaert RF, Barrera FN, Katsaras J, Khelashvili G, Brown MF, Ashkar R. How cholesterol stiffens unsaturated lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32843347 DOI: 10.1073/Pnas.2004807117 |
0.57 |
|
| 2020 |
Schachter I, Allolio C, Khelashvili G, Harries D. Confinement in Nanodiscs Anisotropically Modifies Lipid Bilayer Elastic Properties. The Journal of Physical Chemistry. B. PMID 32697588 DOI: 10.1021/Acs.Jpcb.0C03374 |
0.532 |
|
| 2020 |
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, ... ... Khelashvili G, et al. GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature Methods. PMID 32661425 DOI: 10.1038/S41592-020-0884-Y |
0.348 |
|
| 2020 |
Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, Missel JW, LeVine MV, Gourdon P, Blanchard SC, Javitch JA, Weinstein H, Loland CJ, Nissen P, Gether U. X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications. 11: 1005. PMID 32081981 DOI: 10.1038/S41467-020-14735-W |
0.357 |
|
| 2020 |
Accardi A, Falzone M, Lee B, Cheng X, Khelashvili G, Weinstein H. Structural Basis of Lipid Scrambling and Ion Conduction by TMEM16 Scramblases The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00173 |
0.359 |
|
| 2020 |
Chakraborty S, Molugu TR, Doktorova M, Heberle FA, Scott HL, Kelley EG, Nagao M, Dzikovski BG, Standaert RF, Barrera FN, Katsaras J, Khelashvili G, Brown MF, Ashkar R. Stiffening of Phosphocholine Membranes by Cholesterol Biophysical Journal. 118: 86a. DOI: 10.1016/J.Bpj.2019.11.635 |
0.508 |
|
| 2019 |
Khelashvili G, Chauhan N, Pandey K, Eliezer D, Menon AK. Exchange of water for sterol underlies sterol egress from a StARkin domain. Elife. 8. PMID 31799930 DOI: 10.7554/Elife.53444 |
0.407 |
|
| 2019 |
Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H. Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of Computational Chemistry. PMID 31750558 DOI: 10.1002/Jcc.26105 |
0.554 |
|
| 2019 |
Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H. Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16. Nature Communications. 10: 4972. PMID 31672969 DOI: 10.1038/S41467-019-12865-4 |
0.501 |
|
| 2019 |
Doktorova M, LeVine MV, Khelashvili G, Weinstein H. A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited. Biophysical Journal. PMID 31378312 DOI: 10.1016/j.bpj.2019.07.039 |
0.323 |
|
| 2019 |
LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H. The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31324743 DOI: 10.1073/Pnas.1903020116 |
0.337 |
|
| 2019 |
Plante A, Shore DM, Morra G, Khelashvili G, Weinstein H. A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs. Molecules (Basel, Switzerland). 24. PMID 31159491 DOI: 10.3390/Molecules24112097 |
0.321 |
|
| 2019 |
Doktorova M, LeVine MV, Khelashvili G, Weinstein H. A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited. Biophysical Journal. PMID 30665693 DOI: 10.1016/J.Bpj.2018.12.016 |
0.495 |
|
| 2019 |
Khelashvili G. Mesoscale Computational Modeling of Protein-Membrane Interactions Based on Continuum Mean-Field Theory. Methods in Molecular Biology (Clifton, N.J.). 1860: 15-31. PMID 30317496 DOI: 10.1007/978-1-4939-8760-3_2 |
0.517 |
|
| 2019 |
Khelashvili G, Falzone M, Cheng X, Accardi A, Weinstein H. A Partially Closed State in Nhtmem16 Scramblase is Enabled by Lipid Tail Insertion into the Protein Groove Biophysical Journal. 116: 374a. DOI: 10.1016/J.Bpj.2018.11.2034 |
0.425 |
|
| 2019 |
Ashkar R, Doktorova M, Heberle FA, Scott H, Kelley E, Nagao M, Usery R, Barrera FN, Feigenson GW, Katsaras J, Khelashvili G. Cholesterol Affects the Bending Rigidity of DOPC Membranes Biophysical Journal. 116: 328a. DOI: 10.1016/J.Bpj.2018.11.1780 |
0.69 |
|
| 2018 |
Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A. Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature Communications. 9: 3251. PMID 30108217 DOI: 10.1038/S41467-018-05724-1 |
0.568 |
|
| 2018 |
Herlo R, Lund VK, Lycas MD, Jansen AM, Khelashvili G, Andersen RC, Bhatia V, Pedersen TS, Albornoz PBC, Johner N, Ammendrup-Johnsen I, Christensen NR, Erlendsson S, Stoklund M, Larsen JB, et al. An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1. Cell Reports. 23: 2056-2069. PMID 29768204 DOI: 10.1016/J.Celrep.2018.04.074 |
0.448 |
|
| 2018 |
Razavi AM, Khelashvili G, Weinstein H. How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties. Bmc Biology. 16: 31. PMID 29540172 DOI: 10.1186/S12915-018-0495-6 |
0.315 |
|
| 2018 |
Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC. A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport. Nature Communications. 9: 230. PMID 29335402 DOI: 10.1038/S41467-017-02202-Y |
0.404 |
|
| 2018 |
Doktorova M, Harries D, Khelashvili G. Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations. Physical Chemistry Chemical Physics : Pccp. 19: 16806-16818. PMID 28627570 DOI: 10.1039/C7Cp01921A |
0.541 |
|
| 2018 |
Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G. The GPCR Opsin Translocates Lipids via a Dynamic Mechanism Specified by Markov State Model Analysis of Molecular Dynamics Trajectories Biophysical Journal. 114: 274a. DOI: 10.1016/J.Bpj.2017.11.1582 |
0.412 |
|
| 2017 |
Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G. Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin. Structure (London, England : 1993). PMID 29290486 DOI: 10.1016/J.Str.2017.11.020 |
0.504 |
|
| 2017 |
Pandey K, Ploier B, Goren MA, Levitz J, Khelashvili G, Menon AK. An engineered opsin monomer scrambles phospholipids. Scientific Reports. 7: 16741. PMID 29196630 DOI: 10.1038/S41598-017-16842-Z |
0.497 |
|
| 2017 |
LeVine MV, Cuendet MA, Razavi AM, Khelashvili G, Weinstein H. Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter. Biophysical Journal. PMID 29153319 DOI: 10.1016/J.Bpj.2017.10.030 |
0.331 |
|
| 2017 |
Doktorova M, Heberle FA, Kingston RL, Khelashvili G, Cuendet MA, Wen Y, Katsaras J, Feigenson GW, Vogt VM, Dick RA. Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties. Biophysical Journal. 113: 2004-2015. PMID 29117524 DOI: 10.1016/J.Bpj.2017.08.055 |
0.555 |
|
| 2017 |
Clark LD, Dikiy I, Chapman K, Rödström KEJ, Aramini J, LeVine MV, Khelashvili G, Rasmussen SGF, Gardner KH, Rosenbaum DM. Ligand modulation of sidechain dynamics in a wild-type human GPCR. Elife. 6. PMID 28984574 DOI: 10.1016/J.Bpj.2017.11.1330 |
0.343 |
|
| 2017 |
Verchère A, Ou WL, Ploier B, Morizumi T, Goren MA, Bütikofer P, Ernst OP, Khelashvili G, Menon AK. Light-independent phospholipid scramblase activity of bacteriorhodopsin from Halobacterium salinarum. Scientific Reports. 7: 9522. PMID 28842688 DOI: 10.1038/S41598-017-09835-5 |
0.553 |
|
| 2017 |
Razavi AM, Khelashvili G, Weinstein H. A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter. Scientific Reports. 7: 40076. PMID 28059145 DOI: 10.1038/Srep40076 |
0.325 |
|
| 2017 |
Shore DM, Iaea DB, Rusinova R, Khelashvili G, Cuendet MA, Andersen OS, Maxfield FR, Weinstein H. Vectorial Cholesterol Transport by STARD4 is Mediated by Specific PIP 2 Membrane Composition Biophysical Journal. 112: 87a. DOI: 10.1016/J.Bpj.2016.11.511 |
0.532 |
|
| 2017 |
Doktorova M, Khelashvili G, Weinstein H. Calculating Membrane Area Compressibility from MD Simulations: a Novel Computational Framework Biophysical Journal. 112: 467a. DOI: 10.1016/J.Bpj.2016.11.2507 |
0.453 |
|
| 2017 |
Khelashvili G, Cheol Lee B, Falzone M, Menon AK, Accardi A, Weinstein H. Role of Hydrophilic Groove of the TMEM16 Protein in Lipid Scrambling Biophysical Journal. 112: 392a. DOI: 10.1016/J.Bpj.2016.11.2131 |
0.525 |
|
| 2017 |
Pandey K, Ploier B, Goren M, Khelashvili G, Menon A. An Opsin Monomer Scrambles Phospholipids Biophysical Journal. 112: 391a. DOI: 10.1016/J.Bpj.2016.11.2126 |
0.463 |
|
| 2017 |
Khelashvili G, Pandey K, Weinstein H, Menon AK. Molecular Mechanism of Lipid Scrambling by Opsin Biophysical Journal. 112: 391a. DOI: 10.1016/J.Bpj.2016.11.2125 |
0.593 |
|
| 2017 |
Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J. Combined in Vitro and in Silico Approaches to the Assessment of Stimulant Properties of Novel Psychoactive Substances Biophysical Journal. 112: 338a-339a. DOI: 10.1016/J.Bpj.2016.11.1833 |
0.308 |
|
| 2016 |
Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J. Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 27890676 DOI: 10.1016/J.Pnpbp.2016.11.004 |
0.308 |
|
| 2016 |
Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Conformational dynamics on the extracellular side of LeuT controlled by Na+ and K+ ions and the protonation state of E290. The Journal of Biological Chemistry. PMID 27474737 DOI: 10.1074/Jbc.M116.731455 |
0.321 |
|
| 2016 |
Johner N, Harries D, Khelashvili G. Erratum to: Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations. Bmc Bioinformatics. 17: 236. PMID 27301431 DOI: 10.1186/s12859-016-1091-9 |
0.337 |
|
| 2016 |
Johner N, Harries D, Khelashvili G. Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations. Bmc Bioinformatics. 17: 161. PMID 27071656 DOI: 10.1186/S12859-016-1003-Z |
0.508 |
|
| 2016 |
LeVine MV, Cuendet MA, Khelashvili G, Weinstein H. Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters. Chemical Reviews. PMID 26892914 DOI: 10.1021/Acs.Chemrev.5B00627 |
0.398 |
|
| 2016 |
LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. The role of annular lipids in the functional properties of leucine transporter LeuT proteomicelles. Biochemistry. PMID 26811944 DOI: 10.1021/Acs.Biochem.5B01268 |
0.507 |
|
| 2016 |
Kulig W, Olzynska A, Jurkiewicz P, Kantola AM, Manna M, Pourmousa M, Vazdar M, Cwiklik L, Rog T, Khelashvili G, Harries D, Telkki V, Hof M, Vattulainen I, Jungwirth P. Oxidation of Cholesterol Changes the Physical Properties of Lipid Membranes Biophysical Journal. 110: 84a. DOI: 10.1016/J.Bpj.2015.11.512 |
0.504 |
|
| 2016 |
LeVine MV, Cuendet MA, Khelashvili G, Weinstein H. From Physics to Phenotype: New Insights into Allosteric Transport Mechanisms in LeuT Biophysical Journal. 110: 362a. DOI: 10.1016/J.Bpj.2015.11.1950 |
0.361 |
|
| 2015 |
Khelashvili G, Stanley N, Sahai MA, Medina J, LeVine MV, Shi L, De Fabritiis G, Weinstein H. Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus. Acs Chemical Neuroscience. PMID 26255829 DOI: 10.1021/Acschemneuro.5B00179 |
0.428 |
|
| 2015 |
Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, et al. Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Structure (London, England : 1993). PMID 26073603 DOI: 10.1016/J.Str.2015.04.020 |
0.394 |
|
| 2015 |
Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of Biological Chemistry. 290: 13992-4003. PMID 25869126 DOI: 10.1074/Jbc.M114.625343 |
0.355 |
|
| 2015 |
Khelashvili G, Weinstein H. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochimica Et Biophysica Acta. 1848: 1765-74. PMID 25847498 DOI: 10.1016/J.Bbamem.2015.03.025 |
0.527 |
|
| 2015 |
Kulig W, Ol?y?ska A, Jurkiewicz P, Kantola AM, Komulainen S, Manna M, Pourmousa M, Vazdar M, Cwiklik L, Rog T, Khelashvili G, Harries D, Telkki VV, Hof M, Vattulainen I, et al. Cholesterol under oxidative stress-How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols. Free Radical Biology & Medicine. 84: 30-41. PMID 25795515 DOI: 10.1016/J.Freeradbiomed.2015.03.006 |
0.504 |
|
| 2015 |
Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins. 83: 952-69. PMID 25739722 DOI: 10.1002/Prot.24792 |
0.48 |
|
| 2015 |
Akyuz N, Georgieva ER, Zhou Z, Stolzenberg S, Cuendet MA, Khelashvili G, Altman RB, Terry DS, Freed JH, Weinstein H, Boudker O, Blanchard SC. Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 518: 68-73. PMID 25652997 DOI: 10.1038/Nature14158 |
0.333 |
|
| 2015 |
LeVine MV, Khelashvili G, Shi L, Quick M, Javitch J, Weinstein H. The Role of Annular Lipids in the Mechanism of Membrane Protein Solubilization and Formation of Functionally Competent Proteomicelles Biophysical Journal. 108: 461a. DOI: 10.1016/J.Bpj.2014.11.2517 |
0.562 |
|
| 2015 |
LeVine MV, Khelashvili G, Weinstein H. Simultaneous Identification, Visualization, and Comparison of Complex Events in Molecular Dynamics Simulations Biophysical Journal. 108: 379a-380a. DOI: 10.1016/J.Bpj.2014.11.2082 |
0.369 |
|
| 2015 |
Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Computational Modeling of the N-Terminus of the Human Dopamine Transporter (hDAT) Biophysical Journal. 108: 252a. DOI: 10.1016/J.Bpj.2014.11.1394 |
0.474 |
|
| 2015 |
Cuendet MA, Stolzenberg S, Khelashvili G, Weinstein H. Molecular Dynamics Simulation Study of a Mutant Construct of the Archaeal Glutamate Transporter GltPh with Transport Rates as Fast as its Human Counterpart Biophysical Journal. 108: 198a. DOI: 10.1016/J.Bpj.2014.11.1092 |
0.414 |
|
| 2015 |
Johner NB, Harries D, Khelashvili G. Determining Material Elastic Properties of Arbitrarily-Shaped Membranes using Molecular Dynamics Simulations with Application to the Inverted Hexagonal Phase Biophysical Journal. 108: 182a. DOI: 10.1016/J.Bpj.2014.11.1004 |
0.549 |
|
| 2015 |
Khelashvili G, Weinstein H. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops Biochimica Et Biophysica Acta - Biomembranes. 1848: 1765-1774. DOI: 10.1016/j.bbamem.2015.03.025 |
0.343 |
|
| 2014 |
Johner N, Harries D, Khelashvili G. Curvature and Lipid Packing Modulate the Elastic Properties of Lipid Assemblies: Comparing HII and Lamellar Phases. The Journal of Physical Chemistry Letters. 5: 4201-6. PMID 26278954 DOI: 10.1021/Jz5022284 |
0.552 |
|
| 2014 |
Perez-Aguilar JM, Shan J, LeVine MV, Khelashvili G, Weinstein H. A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. Journal of the American Chemical Society. 136: 16044-54. PMID 25314362 DOI: 10.1021/Ja508394X |
0.329 |
|
| 2014 |
Mondal S, Khelashvili G, Weinstein H. Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophysical Journal. 106: 2305-16. PMID 24896109 DOI: 10.1016/J.Bpj.2014.04.032 |
0.468 |
|
| 2014 |
Hamilton PJ, Belovich AN, Khelashvili G, Saunders C, Erreger K, Javitch JA, Sitte HH, Weinstein H, Matthies HJ, Galli A. PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nature Chemical Biology. 10: 582-9. PMID 24880859 DOI: 10.1038/Nchembio.1545 |
0.376 |
|
| 2014 |
Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. Protein and lipid interactions driving molecular mechanisms of in meso crystallization. Journal of the American Chemical Society. 136: 3271-84. PMID 24494670 DOI: 10.1021/Ja4129839 |
0.383 |
|
| 2014 |
Khelashvili G, Johner N, Zhao G, Harries D, Scott HL. Molecular origins of bending rigidity in lipids with isolated and conjugated double bonds: the effect of cholesterol. Chemistry and Physics of Lipids. 178: 18-26. PMID 24394210 DOI: 10.1016/J.Chemphyslip.2013.12.012 |
0.724 |
|
| 2014 |
Mondal S, Khelashvili G, Johner N, Weinstein H. How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment Advances in Experimental Medicine and Biology. 796: 55-74. PMID 24158801 DOI: 10.1007/978-94-007-7423-0_4 |
0.533 |
|
| 2014 |
Johner N, Harries D, Khelashvili G. Curvature and lipid packing modulate the elastic properties of lipid assemblies: Comparing HII and lamellar phases Journal of Physical Chemistry Letters. 5: 4201-4206. DOI: 10.1021/jz5022284 |
0.336 |
|
| 2014 |
Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. Protein and lipid interactions driving molecular mechanisms of in meso crystallization Journal of the American Chemical Society. 136: 3271-3284. DOI: 10.1021/ja4129839 |
0.301 |
|
| 2014 |
Kollmitzer B, Heftberger P, Rappolt M, Khelashvili G, Harries D, Pabst G. Protein Partitioning in Liquid-Ordered (LO) / Liquid-Disordered (LD) Domains Depends on Lipid Composition and Protein Shape Biophysical Journal. 106: 510a. DOI: 10.1016/J.Bpj.2013.11.2853 |
0.44 |
|
| 2013 |
Mondal S, Johnston JM, Wang H, Khelashvili G, Filizola M, Weinstein H. Membrane driven spatial organization of GPCRs. Scientific Reports. 3: 2909. PMID 24105260 DOI: 10.1038/Srep02909 |
0.408 |
|
| 2013 |
Khelashvili G, Kollmitzer B, Heftberger P, Pabst G, Harries D. Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases. Journal of Chemical Theory and Computation. 9: 3866-3871. PMID 24039553 DOI: 10.1021/Ct400492E |
0.49 |
|
| 2013 |
Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. Journal of the American Chemical Society. 135: 14266-75. PMID 23980525 DOI: 10.1021/Ja405984V |
0.488 |
|
| 2013 |
Mondal S, Khelashvili G, Shi L, Weinstein H. The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT Chemistry and Physics of Lipids. 169: 27-38. PMID 23376428 DOI: 10.1016/J.Chemphyslip.2013.01.006 |
0.566 |
|
| 2013 |
Khelashvili G, Harries D. How cholesterol tilt modulates the mechanical properties of saturated and unsaturated lipid membranes. The Journal of Physical Chemistry. B. 117: 2411-21. PMID 23323733 DOI: 10.1021/Jp3122006 |
0.561 |
|
| 2013 |
Khelashvili G, Harries D. How sterol tilt regulates properties and organization of lipid membranes and membrane insertions. Chemistry and Physics of Lipids. 169: 113-23. PMID 23291283 DOI: 10.1016/J.Chemphyslip.2012.12.006 |
0.591 |
|
| 2013 |
Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. Like Fish Out of Water: Membrane Proteins in Detergent Micelles Biophysical Journal. 104: 113a. DOI: 10.1016/J.Bpj.2012.11.656 |
0.462 |
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| 2013 |
Mondal S, Khelashvili G, Shi L, Weinstein H. Functional Consequences of Incomplete Hydrophobic Matching at TM1 of the LeuT Transporter Biophysical Journal. 104: 92a-93a. DOI: 10.1016/J.Bpj.2012.11.553 |
0.572 |
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| 2012 |
Khelashvili G, Galli A, Weinstein H. Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure. Biochemistry. 51: 7685-98. PMID 22950482 DOI: 10.1021/Bi300833Z |
0.527 |
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| 2012 |
Khelashvili G, Albornoz PBC, Johner N, Mondal S, Caffrey M, Weinstein H. Why GPCRs behave differently in cubic and lamellar lipidic mesophases Journal of the American Chemical Society. 134: 15858-15868. PMID 22931253 DOI: 10.1021/Ja3056485 |
0.443 |
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| 2012 |
Shan J, Khelashvili G, Mondal S, Mehler EL, Weinstein H. Ligand-dependent conformations and dynamics of the serotonin 5-HT2A receptor determine its activation and membrane-driven oligomerization properties Plos Computational Biology. 8. PMID 22532793 DOI: 10.1371/Journal.Pcbi.1002473 |
0.417 |
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| 2012 |
Stolzenberg S, Khelashvili G, Weinstein H. Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh. The Journal of Physical Chemistry. B. 116: 5372-83. PMID 22494242 DOI: 10.1021/Jp301726S |
0.417 |
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| 2012 |
Stolzenberg S, Khelashvili G, Weinstein H. Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh Journal of Physical Chemistry B. 116: 5372-5383. DOI: 10.1016/J.Bpj.2011.11.2839 |
0.399 |
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| 2012 |
Mondal S, Khelashvili G, Khangulova (Johnston) J, Wang H, Provasi D, Andersen OS, Filizola M, Weinstein H. Interaction with the Membrane Uncovers Essential Differences Between Highly Homologous GPCRs Biophysical Journal. 102: 514a. DOI: 10.1016/J.Bpj.2011.11.2814 |
0.505 |
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| 2012 |
Khelashvili G, Mondal S, Caffrey M, Weinstein H. Quantitative Comparison of GPCR Interactions with the Lipid Bilayer of the Cubic and Lamellar Mesophases Biophysical Journal. 102: 467a-468a. DOI: 10.1016/J.Bpj.2011.11.2565 |
0.455 |
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| 2012 |
Khelashvili G, Galli A, Weinstein H. How PIP2 Lipids Regulate the Position and Phosphorylation of the Syntaxin N-Terminus Biophysical Journal. 102: 433a. DOI: 10.1016/J.Bpj.2011.11.2373 |
0.563 |
|
| 2011 |
Khelashvili G, Rappolt M, Chiu SW, Pabst G, Harries D. Impact of sterol tilt on membrane bending rigidity in cholesterol and 7DHC-containing DMPC membranes. Soft Matter. 7: 10299-10312. PMID 23173009 DOI: 10.1039/C1Sm05937H |
0.546 |
|
| 2011 |
Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H. Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophysical Journal. 101: 2092-101. PMID 22067146 DOI: 10.1016/J.Bpj.2011.09.037 |
0.514 |
|
| 2011 |
Mondal S, Khelashvili G, Shan J, Shi L, Andersen O, Weinstein H. Quantitative Analysis of Membrane Deformation by Multi-Helical Transmembrane Proteins Biophysical Journal. 100: 492a. DOI: 10.1016/J.Bpj.2010.12.2883 |
0.546 |
|
| 2011 |
Shan J, Khelashvili G, Mondal S, Weinstein H. Pharmacologically Distinct Ligands Induce Different States of 5-HT2AR and Trigger Different Membrane Remodeling: Implications For GPCR Oligomerization Biophysical Journal. 100: 254a. DOI: 10.1016/J.Bpj.2010.12.1605 |
0.438 |
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| 2010 |
Khelashvili G, Mondal S, Andersen OS, Weinstein H. Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. The Journal of Physical Chemistry. B. 114: 12046-57. PMID 20804205 DOI: 10.1021/Jp106373R |
0.573 |
|
| 2010 |
Khelashvili G, Pabst G, Harries D. Cholesterol orientation and tilt modulus in DMPC bilayers. The Journal of Physical Chemistry. B. 114: 7524-34. PMID 20518573 DOI: 10.1021/Jp101889K |
0.504 |
|
| 2010 |
Khelashvili G, Harries D. Modeling signaling processes across cellular membranes using a mesoscopic approach Annual Reports in Computational Chemistry. 6: 237-261. DOI: 10.1016/S1574-1400(10)06012-3 |
0.487 |
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| 2010 |
Shan J, Khelashvili G, Weinstein H. Large-Scale MD Simulations Reveal Structural Elements of the Activated State in the 5-HT2a Receptor and their Relation to Cholesterol Dynamics Biophysical Journal. 98: 419a. DOI: 10.1016/J.Bpj.2009.12.2264 |
0.408 |
|
| 2009 |
Khelashvili G, Harries D, Weinstein H. Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption. Biophysical Journal. 97: 1626-35. PMID 19751667 DOI: 10.1016/J.Bpj.2009.07.006 |
0.543 |
|
| 2009 |
Khelashvili G, Grossfield A, Feller SE, Pitman MC, Weinstein H. Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations. Proteins. 76: 403-17. PMID 19173312 DOI: 10.1002/Prot.22355 |
0.502 |
|
| 2009 |
Khelashvili G, Harries D, Weinstein H. Adsorption Of Bar-domain Proteins To Charged Lipid Membranes Causes Deformations And Lipid Demixing Biophysical Journal. 96: 95a. DOI: 10.1016/J.Bpj.2008.12.401 |
0.528 |
|
| 2009 |
Scott HL, Khelashvili G, Pandit S. Molecular Dynamics simulation of a large asymmetric lipid bilayer Biophysical Journal. 96: 460a. DOI: 10.1016/J.Bpj.2008.12.2369 |
0.718 |
|
| 2008 |
Khelashvili G, Weinstein H, Harries D. Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization. Biophysical Journal. 94: 2580-97. PMID 18065451 DOI: 10.1529/Biophysj.107.120667 |
0.529 |
|
| 2007 |
Pandit SA, Khelashvili G, Jakobsson E, Grama A, Scott HL. Lateral organization in lipid-cholesterol mixed bilayers. Biophysical Journal. 92: 440-7. PMID 17071661 DOI: 10.1529/Biophysj.106.093864 |
0.71 |
|
| 2005 |
Khelashvili GA, Pandit SA, Scott HL. Self-consistent mean-field model based on molecular dynamics: application to lipid-cholesterol bilayers. The Journal of Chemical Physics. 123: 34910. PMID 16080766 DOI: 10.1063/1.1943412 |
0.66 |
|
| 2004 |
Khelashvili GA, Scott HL. Combined Monte Carlo and molecular dynamics simulation of hydrated 18:0 sphingomyelin-cholesterol lipid bilayers. The Journal of Chemical Physics. 120: 9841-7. PMID 15268001 DOI: 10.1063/1.1724814 |
0.624 |
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