Hengming Ke - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Biochemistry, General Biophysics, Molecular Biology

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Immunity. 50: 591-599.e6. PMID 30893587 DOI: 10.1016/j.immuni.2019.02.009  0.44
2019 Zhu C, Dukhovlinova E, Council O, Ping L, Faison EM, Prabhu SS, Potter EL, Upton SL, Yin G, Fay JM, Kincer LP, Spielvogel E, Campbell SL, Benhabbour SR, Ke H, et al. Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies. Nature Communications. 10: 948. PMID 30814513 DOI: 10.1038/s41467-019-08876-w  0.44
2018 Yao T, Huang Y, Zhang M, Chen Y, Pei H, Shi J, Wang H, Wang Y, Ke H. Crystal structures of Candida albicans phosphodiesterase-2 and implication on its biological functions. Biochemistry. PMID 30231198 DOI: 10.1021/acs.biochem.8b00707  1
2018 Feng X, Wang H, Ye M, Xu XT, Xu Y, Yang W, Zhang H, Song G, Ke H. Identification of a PDE4-specific pocket for design of selective inhibitors. Biochemistry. PMID 29975048 DOI: 10.1021/acs.biochem.8b00336  0.96
2017 Wang Y, Ke H. A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS. Advances in Neurobiology. 17: 463-471. PMID 28956343 DOI: 10.1007/978-3-319-58811-7_17  1
2017 Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH. Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. Ebiomedicine. PMID 28396013 DOI: 10.1016/j.ebiom.2017.03.019  0.36
2016 Fay JM, Zhu C, Proctor EA, Tao Y, Cui W, Ke H, Dokholyan NV. A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation. Structure (London, England : 1993). PMID 27667694 DOI: 10.1016/j.str.2016.08.011  0.48
2016 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Bairathi V, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... Ke HW, et al. Centrality and Transverse Momentum Dependence of Elliptic Flow of Multistrange Hadrons and ϕ Meson in Au+Au Collisions at sqrt[s_{NN}]=200  GeV. Physical Review Letters. 116: 062301. PMID 26918982 DOI: 10.1103/PhysRevLett.116.062301  1
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... Ke HW, et al. Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in p^{↑}+p at sqrt[s]=200  GeV. Physical Review Letters. 115: 242501. PMID 26705627 DOI: 10.1103/PhysRevLett.115.242501  1
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... Ke HW, et al. Precision Measurement of the Longitudinal Double-Spin Asymmetry for Inclusive Jet Production in Polarized Proton Collisions at sqrt[s]=200  GeV. Physical Review Letters. 115: 092002. PMID 26371644  1
2015 Huang M, Shao Y, Hou J, Cai W, Liang B, Huang Y, Li Z, Wu Y, Zhu X, Liu P, Wan Y, Ke H, Luo HB. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Molecular Pharmacology. PMID 26316540 DOI: 10.1124/mol.115.099747  0.96
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... Ke HW, et al. Observation of Charge Asymmetry Dependence of Pion Elliptic Flow and the Possible Chiral Magnetic Wave in Heavy-Ion Collisions. Physical Review Letters. 114: 252302. PMID 26197122  1
2015 Leslie PL, Ke H, Zhang Y. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. The Journal of Biological Chemistry. 290: 12941-50. PMID 25809483 DOI: 10.1074/jbc.M115.644435  0.96
2015 Li J, Wang H, Ke H, Ni S. MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 36: 5785-90. PMID 25716201 DOI: 10.1007/s13277-015-3247-z  0.44
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. ΛΛ Correlation function in Au+Au collisions at √[S(NN)]=200  GeV. Physical Review Letters. 114: 022301. PMID 25635541  1
2015 Chen XH, Liu ZC, Zhang G, Wei W, Wang XX, Wang H, Ke HP, Zhang F, Wang HS, Cai SH, Du J. TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. Molecular Immunology. 65: 34-42. PMID 25618241 DOI: 10.1016/j.molimm.2014.12.017  0.36
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Observation of D0 meson nuclear modifications in Au+Au collisions at sqrt[s(NN)] = 200 GeV. Physical Review Letters. 113: 142301. PMID 25325635  1
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... Ke HW, et al. Beam energy dependence of moments of the net-charge multiplicity distributions in Au+Au collisions at RHIC. Physical Review Letters. 113: 092301. PMID 25215979  1
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Beam-energy dependence of charge separation along the magnetic field in Au+Au collisions at RHIC. Physical Review Letters. 113: 052302. PMID 25126911  1
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Barnovska Z, Beavis DR, ... Ke HW, et al. Dielectron mass spectra from Au+Au collisions at √[s(NN)]=200  GeV. Physical Review Letters. 113: 022301. PMID 25062167  1
2014 Tian Y, Cui W, Huang M, Robinson H, Wan Y, Wang Y, Ke H. Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Biochemistry. 53: 4938-45. PMID 25050706 DOI: 10.1021/bi500406h  1
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... Ke HW, et al. Beam-energy dependence of the directed flow of protons, antiprotons, and pions in Au+Au collisions. Physical Review Letters. 112: 162301. PMID 24815640  1
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Jet-hadron correlations in √[s(NN)]=200  GeV p+p and central Au+Au collisions. Physical Review Letters. 112: 122301. PMID 24724645  1
2014 Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. Advances in targeting cyclic nucleotide phosphodiesterases. Nature Reviews. Drug Discovery. 13: 290-314. PMID 24687066 DOI: 10.1038/nrd4228  1
2014 Shang NN, Shao YX, Cai YH, Guan M, Huang M, Cui W, He L, Yu YJ, Huang L, Li Z, Bu XZ, Ke H, Luo HB. Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochemical Pharmacology. 89: 86-98. PMID 24565909 DOI: 10.1016/j.bcp.2014.02.013  0.96
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Energy dependence of moments of net-proton multiplicity distributions at RHIC. Physical Review Letters. 112: 032302. PMID 24484135  1
2013 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Observation of an energy-dependent difference in elliptic flow between particles and antiparticles in relativistic heavy ion collisions. Physical Review Letters. 110: 142301. PMID 25166982  0.96
2013 Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. Journal of Medicinal Chemistry. 56: 2087-96. PMID 23409953 DOI: 10.1021/jm3017877  0.96
2013 Wang H, Ke H, Lin SY, Guo Y, Zhao L, Tang J, Li YH. Heterometallic octanuclear RE(III)3Ni(II)5 (RE = Dy(III), Gd(III) and Y(III)) clusters with slow magnetic relaxation for the dysprosium derivative. Dalton Transactions (Cambridge, England : 2003). 42: 5298-303. PMID 23403627 DOI: 10.1039/c3dt32572e  0.96
2012 Adamczyk L, Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Banerjee A, Barnovska Z, Beavis DR, ... ... Ke HW, et al. Directed flow of identified particles in Au+Au collisions at √[SNN]=200  GeV at RHIC. Physical Review Letters. 108: 202301. PMID 23003142  1
2012 Meng F, Hou J, Shao YX, Wu PY, Huang M, Zhu X, Cai Y, Li Z, Xu J, Liu P, Luo HB, Wan Y, Ke H. Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design. Journal of Medicinal Chemistry. 55: 8549-58. PMID 22985069 DOI: 10.1021/jm301189c  0.48
2012 Yuan Q, He L, Ke H. A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activity. Antimicrobial Agents and Chemotherapy. 56: 5157-63. PMID 22825119 DOI: 10.1128/AAC.05896-11  0.36
2012 Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Bellwied R, Betancourt MJ, ... ... Ke HW, et al. Identified hadron compositions in p+p and Au+Au collisions at high transverse momenta at √S(NN)=200 GeV. Physical Review Letters. 108: 072302. PMID 22401197  0.48
2012 Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Behera NK, Bellwied R, ... ... Ke HW, et al. Strangeness enhancement in Cu-Cu and Au-Au collisions at √S(NN)=200 GeV. Physical Review Letters. 108: 072301. PMID 22401196  1
2012 Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, Martinelli S, Ke H. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of Biological Chemistry. 287: 11788-97. PMID 22356915 DOI: 10.1074/jbc.M111.326777  0.96
2012 Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 148: 421-33. PMID 22304913 DOI: 10.1016/j.cell.2012.01.017  0.96
2011 Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, ... ... Ke H, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147: 223-34. PMID 21962518 DOI: 10.1016/j.cell.2011.08.037  0.96
2011 Seebeck T, Sterk GJ, Ke H. Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite. Future Medicinal Chemistry. 3: 1289-306. PMID 21859303 DOI: 10.4155/fmc.11.77  0.96
2011 Shakur Y, de Koning HP, Ke H, Kambayashi J, Seebeck T. Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases. Handbook of Experimental Pharmacology. 487-510. PMID 21695653 DOI: 10.1007/978-3-642-17969-3_20  0.32
2011 Ke H, Wang H, Ye M. Structural insight into the substrate specificity of phosphodiesterases. Handbook of Experimental Pharmacology. 121-34. PMID 21695637 DOI: 10.1007/978-3-642-17969-3_4  0.96
2011 Hou J, Xu J, Liu M, Zhao R, Luo HB, Ke H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine. Plos One. 6: e18092. PMID 21483814 DOI: 10.1371/journal.pone.0018092  0.44
2011 Francis SH, Sekhar KR, Ke H, Corbin JD. Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds. Handbook of Experimental Pharmacology. 93-133. PMID 20859794 DOI: 10.1007/978-3-642-13443-2_4  0.96
2010 Wang H, Robinson H, Ke H. Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. The Journal of Biological Chemistry. 285: 38149-56. PMID 20861010 DOI: 10.1074/jbc.M110.141614  0.96
2010 Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, Lee AL. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry. 49: 9280-91. PMID 20839809 DOI: 10.1021/bi101131f  0.96
2010 Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis. Journal of Medicinal Chemistry. 53: 1726-31. PMID 20121115 DOI: 10.1021/jm901519f  0.96
2009 Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, Wang H, Ke H, Nikolaev VO, Jaffe LA. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (Cambridge, England). 136: 1869-78. PMID 19429786 DOI: 10.1242/dev.035238  0.96
2009 Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H, Gil C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. Chemmedchem. 4: 866-76. PMID 19350606 DOI: 10.1002/cmdc.200900043  0.96
2009 Itahana Y, Ke H, Zhang Y. p53 Oligomerization is essential for its C-terminal lysine acetylation. The Journal of Biological Chemistry. 284: 5158-64. PMID 19106109 DOI: 10.1074/jbc.M805696200  0.32
2009 Yan Z, Wang H, Cai J, Ke H. Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain. Protein Expression and Purification. 64: 82-8. PMID 18984055 DOI: 10.1016/j.pep.2008.10.005  0.96
2008 Hu X, Wang H, Ke H, Kuhlman B. Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design. Structure (London, England : 1993). 16: 1799-805. PMID 19081056 DOI: 10.1016/j.str.2008.09.013  0.96
2008 Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H. Design, synthesis, and structure - Activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors Journal of Medicinal Chemistry. 51: 7673-7688. PMID 19049349 DOI: 10.1021/jm701635j  0.96
2008 Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry. 47: 12760-8. PMID 18983167 DOI: 10.1021/bi801487x  0.96
2008 Chen G, Wang H, Robinson H, Cai J, Wan Y, Ke H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies. Biochemical Pharmacology. 75: 1717-28. PMID 18346713 DOI: 10.1016/j.bcp.2008.01.019  0.96
2008 Wang H, Ye M, Robinson H, Francis SH, Ke H. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Molecular Pharmacology. 73: 104-10. PMID 17959709 DOI: 10.1124/mol.107.040212  0.96
2007 Hu X, Wang H, Ke H, Kuhlman B. High-resolution design of a protein loop. Proceedings of the National Academy of Sciences of the United States of America. 104: 17668-73. PMID 17971437 DOI: 10.1073/pnas.0707977104  0.96
2007 Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Molecular Microbiology. 66: 1029-38. PMID 17944832 DOI: 10.1111/j.1365-2958.2007.05976.x  0.96
2007 Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. The Biochemical Journal. 408: 193-201. PMID 17727341 DOI: 10.1042/BJ20070970  0.96
2007 Wang H, Robinson H, Ke H. The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. Journal of Molecular Biology. 371: 302-7. PMID 17582435 DOI: 10.1016/j.jmb.2007.05.060  0.96
2007 Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proceedings of the National Academy of Sciences of the United States of America. 104: 5782-7. PMID 17389385 DOI: 10.1073/pnas.0700279104  0.96
2007 Ke H, Wang H. Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Current Topics in Medicinal Chemistry. 7: 391-403. PMID 17305581 DOI: 10.2174/156802607779941242  0.96
2006 Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH. A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization. Molecular Pharmacology. 70: 1822-31. PMID 16926278 DOI: 10.1124/mol.106.028688  0.96
2006 Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H. Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. The Journal of Biological Chemistry. 281: 21469-79. PMID 16735511 DOI: 10.1074/jbc.M512527200  0.96
2006 Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y. Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. The Journal of Biological Chemistry. 281: 18463-72. PMID 16679321 DOI: 10.1074/jbc.M602788200  0.32
2006 Huai Q, Sun Y, Wang H, Macdonald D, Aspiotis R, Robinson H, Huang Z, Ke H. Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. Journal of Medicinal Chemistry. 49: 1867-73. PMID 16539372 DOI: 10.1021/jm051273d  0.96
2005 Wang H, Liu Y, Chen Y, Robinson H, Ke H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. The Journal of Biological Chemistry. 280: 30949-55. PMID 15994308 DOI: 10.1074/jbc.M504398200  0.96
2005 Ke H, Huai Q, Xu RX. Crystallization of cyclic nucleotide phosphodiesterases. Methods in Molecular Biology (Clifton, N.J.). 307: 181-90. PMID 15988064 DOI: 10.1385/1-59259-839-0:181  0.96
2005 Huai Q, Wang H, Liu Y, Kim HY, Toft D, Ke H. Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure (London, England : 1993). 13: 579-90. PMID 15837196 DOI: 10.1016/j.str.2004.12.018  0.96
2004 Ke H, Huai Q. Crystal structures of cyclophilin and its partners. Frontiers in Bioscience : a Journal and Virtual Library. 9: 2285-96. PMID 15353287  0.96
2004 Huai Q, Wang H, Zhang W, Colman RW, Robinson H, Ke H. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Proceedings of the National Academy of Sciences of the United States of America. 101: 9624-9. PMID 15210993 DOI: 10.1073/pnas.0401120101  0.96
2004 Huai Q, Liu Y, Francis SH, Corbin JD, Ke H. Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity. The Journal of Biological Chemistry. 279: 13095-101. PMID 14668322 DOI: 10.1074/jbc.M311556200  0.96
2004 Olzmann JA, Brown K, Wilkinson KD, Rees HD, Huai Q, Ke H, Levey AI, Li L, Chin LS. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. The Journal of Biological Chemistry. 279: 8506-15. PMID 14665635 DOI: 10.1074/jbc.M311017200  0.96
2003 Ke H, Huai Q. Structures of calcineurin and its complexes with immunophilins-immunosuppressants. Biochemical and Biophysical Research Communications. 311: 1095-102. PMID 14623295 DOI: 10.1016/S0006-291X(03)01537-7  0.96
2003 Huai Q, Colicelli J, Ke H. The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis. Biochemistry. 42: 13220-6. PMID 14609333 DOI: 10.1021/bi034653e  0.64
2003 Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. Febs Letters. 549: 171-5. PMID 12914946  0.96
2003 Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H. Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. Structure (London, England : 1993). 11: 865-73. PMID 12842049  0.96
2002 Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 12037-42. PMID 12218175 DOI: 10.1073/pnas.192206699  0.96
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