| Year |
Citation |
Score |
| 2020 |
Gupta R, Liu Y, Wang H, Nordyke CT, Puterbaugh RZ, Cui W, Varga K, Chu F, Ke H, Vashisth H, Cote RH. Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. Journal of Molecular Biology. PMID 32898583 DOI: 10.1016/J.Jmb.2020.08.026 |
0.639 |
|
| 2020 |
Zhang T, Lai Z, Yuan S, Huang YY, Dong G, Sheng C, Ke H, Luo HB. Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket. Journal of Medicinal Chemistry. PMID 32794708 DOI: 10.1021/Acs.Jmedchem.0C00983 |
0.408 |
|
| 2018 |
Yao T, Huang Y, Zhang M, Chen Y, Pei H, Shi J, Wang H, Wang Y, Ke H. Crystal structures of Candida albicans phosphodiesterase-2 and implication on its biological functions. Biochemistry. PMID 30231198 DOI: 10.1021/Acs.Biochem.8B00707 |
0.662 |
|
| 2018 |
Feng X, Wang H, Ye M, Xu XT, Xu Y, Yang W, Zhang H, Song G, Ke H. Identification of a PDE4-specific pocket for design of selective inhibitors. Biochemistry. PMID 29975048 DOI: 10.1021/Acs.Biochem.8B00336 |
0.657 |
|
| 2016 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Banerjee A, Bellwied R, ... ... Ke HW, et al. Measurement of the Transverse Single-Spin Asymmetry in p^{↑}+p→W^{±}/Z^{0} at RHIC. Physical Review Letters. 116: 132301. PMID 27081970 DOI: 10.1103/Physrevlett.116.132301 |
0.556 |
|
| 2016 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Bellwied R, Bhasin A, ... ... Ke HW, et al. Beam Energy Dependence of the Third Harmonic of Azimuthal Correlations in Au+Au Collisions at RHIC. Physical Review Letters. 116: 112302. PMID 27035295 DOI: 10.1103/Physrevlett.116.112302 |
0.566 |
|
| 2016 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Bairathi V, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Centrality and Transverse Momentum Dependence of Elliptic Flow of Multistrange Hadrons and ϕ Meson in Au+Au Collisions at sqrt[s_{NN}]=200 GeV. Physical Review Letters. 116: 062301. PMID 26918982 DOI: 10.1103/Physrevlett.116.062301 |
0.582 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in p^{↑}+p at sqrt[s]=200 GeV. Physical Review Letters. 115: 242501. PMID 26705627 DOI: 10.1103/Physrevlett.115.242501 |
0.554 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Azimuthal Anisotropy in U+U and Au+Au Collisions at RHIC. Physical Review Letters. 115: 222301. PMID 26650297 DOI: 10.1103/Physrevlett.115.222301 |
0.57 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Precision Measurement of the Longitudinal Double-Spin Asymmetry for Inclusive Jet Production in Polarized Proton Collisions at sqrt[s]=200 GeV. Physical Review Letters. 115: 092002. PMID 26371644 DOI: 10.1103/Physrevlett.115.092002 |
0.542 |
|
| 2015 |
Huang M, Shao Y, Hou J, Cai W, Liang B, Huang Y, Li Z, Wu Y, Zhu X, Liu P, Wan Y, Ke H, Luo HB. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Molecular Pharmacology. PMID 26316540 DOI: 10.1124/Mol.115.099747 |
0.374 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Observation of Charge Asymmetry Dependence of Pion Elliptic Flow and the Possible Chiral Magnetic Wave in Heavy-Ion Collisions. Physical Review Letters. 114: 252302. PMID 26197122 DOI: 10.1103/Physrevlett.114.252302 |
0.557 |
|
| 2015 |
Leslie PL, Ke H, Zhang Y. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. The Journal of Biological Chemistry. 290: 12941-50. PMID 25809483 DOI: 10.1074/Jbc.M115.644435 |
0.347 |
|
| 2015 |
Li J, Wang H, Ke H, Ni S. MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 36: 5785-90. PMID 25716201 DOI: 10.1007/s13277-015-3247-z |
0.52 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. ΛΛ Correlation function in Au+Au collisions at √[S(NN)]=200 GeV. Physical Review Letters. 114: 022301. PMID 25635541 DOI: 10.1103/Physrevlett.114.022301 |
0.556 |
|
| 2015 |
Chen XH, Liu ZC, Zhang G, Wei W, Wang XX, Wang H, Ke HP, Zhang F, Wang HS, Cai SH, Du J. TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. Molecular Immunology. 65: 34-42. PMID 25618241 DOI: 10.1016/J.Molimm.2014.12.017 |
0.499 |
|
| 2014 |
Shao YX, Huang M, Cui W, Feng LJ, Wu Y, Cai Y, Li Z, Zhu X, Liu P, Wan Y, Ke H, Luo HB. Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent. Journal of Medicinal Chemistry. 57: 10304-13. PMID 25432025 DOI: 10.1021/Jm500836H |
0.319 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Observation of D0 meson nuclear modifications in Au+Au collisions at sqrt[s(NN)] = 200 GeV. Physical Review Letters. 113: 142301. PMID 25325635 DOI: 10.1103/Physrevlett.113.142301 |
0.563 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Beam energy dependence of moments of the net-charge multiplicity distributions in Au+Au collisions at RHIC. Physical Review Letters. 113: 092301. PMID 25215979 DOI: 10.1103/Physrevlett.113.092301 |
0.551 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Beavis DR, ... ... Ke HW, et al. Measurement of longitudinal spin asymmetries for weak boson production in polarized proton-proton collisions at RHIC. Physical Review Letters. 113: 072301. PMID 25170701 DOI: 10.1103/Physrevlett.113.072301 |
0.546 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Beam-energy dependence of charge separation along the magnetic field in Au+Au collisions at RHIC. Physical Review Letters. 113: 052302. PMID 25126911 DOI: 10.1103/Physrevlett.113.052302 |
0.561 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Barnovska Z, Beavis DR, ... ... Ke HW, et al. Dielectron mass spectra from Au+Au collisions at √[s(NN)]=200 GeV. Physical Review Letters. 113: 022301. PMID 25062167 DOI: 10.1103/Physrevlett.113.022301 |
0.561 |
|
| 2014 |
Tian Y, Cui W, Huang M, Robinson H, Wan Y, Wang Y, Ke H. Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Biochemistry. 53: 4938-45. PMID 25050706 DOI: 10.1021/Bi500406H |
0.387 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Beam-energy dependence of the directed flow of protons, antiprotons, and pions in Au+Au collisions. Physical Review Letters. 112: 162301. PMID 24815640 DOI: 10.1103/Physrevlett.112.162301 |
0.569 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Jet-hadron correlations in √[s(NN)]=200 GeV p+p and central Au+Au collisions. Physical Review Letters. 112: 122301. PMID 24724645 DOI: 10.1103/Physrevlett.112.122301 |
0.558 |
|
| 2014 |
Shang NN, Shao YX, Cai YH, Guan M, Huang M, Cui W, He L, Yu YJ, Huang L, Li Z, Bu XZ, Ke H, Luo HB. Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochemical Pharmacology. 89: 86-98. PMID 24565909 DOI: 10.1016/J.Bcp.2014.02.013 |
0.421 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Energy dependence of moments of net-proton multiplicity distributions at RHIC. Physical Review Letters. 112: 032302. PMID 24484135 DOI: 10.1103/Physrevlett.112.032302 |
0.566 |
|
| 2013 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Observation of an energy-dependent difference in elliptic flow between particles and antiparticles in relativistic heavy ion collisions. Physical Review Letters. 110: 142301. PMID 25166982 DOI: 10.1103/Physrevlett.110.142301 |
0.552 |
|
| 2013 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Measurement of J/ψ azimuthal anisotropy in Au+Au collisions at sqrt[s(NN)]=200 GeV. Physical Review Letters. 111: 052301. PMID 23952389 DOI: 10.1103/Physrevlett.111.052301 |
0.562 |
|
| 2013 |
Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. Journal of Medicinal Chemistry. 56: 2087-96. PMID 23409953 DOI: 10.1021/Jm3017877 |
0.647 |
|
| 2013 |
Wang H, Ke H, Lin SY, Guo Y, Zhao L, Tang J, Li YH. Heterometallic octanuclear RE(III)3Ni(II)5 (RE = Dy(III), Gd(III) and Y(III)) clusters with slow magnetic relaxation for the dysprosium derivative. Dalton Transactions (Cambridge, England : 2003). 42: 5298-303. PMID 23403627 DOI: 10.1039/c3dt32572e |
0.529 |
|
| 2012 |
Adamczyk L, Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Banerjee A, Barnovska Z, Beavis DR, ... ... Ke HW, et al. Directed flow of identified particles in Au+Au collisions at √[SNN]=200 GeV at RHIC. Physical Review Letters. 108: 202301. PMID 23003142 DOI: 10.1103/Physrevlett.108.202301 |
0.566 |
|
| 2012 |
Meng F, Hou J, Shao YX, Wu PY, Huang M, Zhu X, Cai Y, Li Z, Xu J, Liu P, Luo HB, Wan Y, Ke H. Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design. Journal of Medicinal Chemistry. 55: 8549-58. PMID 22985069 DOI: 10.1021/Jm301189C |
0.405 |
|
| 2012 |
Chen HL, Chen YC, Lu MY, Chang JJ, Wang HT, Ke HM, Wang TY, Ruan SK, Wang TY, Hung KY, Cho HY, Lin WT, Shih MC, Li WH. A highly efficient β-glucosidase from the buffalo rumen fungus Neocallimastix patriciarum W5. Biotechnology For Biofuels. 5: 24. PMID 22515264 DOI: 10.1186/1754-6834-5-24 |
0.556 |
|
| 2012 |
Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Bellwied R, Betancourt MJ, ... ... Ke HW, et al. Identified hadron compositions in p+p and Au+Au collisions at high transverse momenta at √S(NN)=200 GeV. Physical Review Letters. 108: 072302. PMID 22401197 DOI: 10.1103/Physrevlett.108.072302 |
0.542 |
|
| 2012 |
Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Behera NK, Bellwied R, ... ... Ke HW, et al. Strangeness enhancement in Cu-Cu and Au-Au collisions at √S(NN)=200 GeV. Physical Review Letters. 108: 072301. PMID 22401196 DOI: 10.1103/Physrevlett.108.072301 |
0.528 |
|
| 2012 |
Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, Martinelli S, Ke H. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of Biological Chemistry. 287: 11788-97. PMID 22356915 DOI: 10.1074/Jbc.M111.326777 |
0.671 |
|
| 2011 |
Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, ... ... Ke H, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147: 223-34. PMID 21962518 DOI: 10.1016/J.Cell.2011.08.037 |
0.61 |
|
| 2011 |
Chou YH, Li CC, Hsu H, Chang WC, Liu CC, Li WM, Ke HL, Lee MH, Liu ME, Pan SC, Wang HS. Renal function in patients with urinary stones of varying compositions. The Kaohsiung Journal of Medical Sciences. 27: 264-7. PMID 21757143 DOI: 10.1016/j.kjms.2010.11.008 |
0.497 |
|
| 2011 |
Ke H, Wang H, Ye M. Structural insight into the substrate specificity of phosphodiesterases. Handbook of Experimental Pharmacology. 121-34. PMID 21695637 DOI: 10.1007/978-3-642-17969-3_4 |
0.658 |
|
| 2011 |
Hou J, Xu J, Liu M, Zhao R, Luo HB, Ke H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine. Plos One. 6: e18092. PMID 21483814 DOI: 10.1371/Journal.Pone.0018092 |
0.433 |
|
| 2011 |
Francis SH, Sekhar KR, Ke H, Corbin JD. Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds. Handbook of Experimental Pharmacology. 93-133. PMID 20859794 DOI: 10.1007/978-3-642-13443-2_4 |
0.322 |
|
| 2010 |
Wang H, Robinson H, Ke H. Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. The Journal of Biological Chemistry. 285: 38149-56. PMID 20861010 DOI: 10.1074/Jbc.M110.141614 |
0.629 |
|
| 2010 |
Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, Lee AL. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry. 49: 9280-91. PMID 20839809 DOI: 10.1021/Bi101131F |
0.611 |
|
| 2010 |
Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis. Journal of Medicinal Chemistry. 53: 1726-31. PMID 20121115 DOI: 10.1021/Jm901519F |
0.657 |
|
| 2009 |
Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, Wang H, Ke H, Nikolaev VO, Jaffe LA. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (Cambridge, England). 136: 1869-78. PMID 19429786 DOI: 10.1242/Dev.035238 |
0.573 |
|
| 2009 |
Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H, Gil C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. Chemmedchem. 4: 866-76. PMID 19350606 DOI: 10.1002/Cmdc.200900043 |
0.606 |
|
| 2009 |
Yan Z, Wang H, Cai J, Ke H. Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain. Protein Expression and Purification. 64: 82-8. PMID 18984055 DOI: 10.1016/J.Pep.2008.10.005 |
0.61 |
|
| 2008 |
Hu X, Wang H, Ke H, Kuhlman B. Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design. Structure (London, England : 1993). 16: 1799-805. PMID 19081056 DOI: 10.1016/J.Str.2008.09.013 |
0.573 |
|
| 2008 |
Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H. Design, synthesis, and structure - Activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors Journal of Medicinal Chemistry. 51: 7673-7688. PMID 19049349 DOI: 10.1021/Jm701635J |
0.599 |
|
| 2008 |
Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry. 47: 12760-8. PMID 18983167 DOI: 10.1021/Bi801487X |
0.671 |
|
| 2008 |
Chen G, Wang H, Robinson H, Cai J, Wan Y, Ke H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies. Biochemical Pharmacology. 75: 1717-28. PMID 18346713 DOI: 10.1016/J.Bcp.2008.01.019 |
0.668 |
|
| 2008 |
Wang H, Ye M, Robinson H, Francis SH, Ke H. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Molecular Pharmacology. 73: 104-10. PMID 17959709 DOI: 10.1124/Mol.107.040212 |
0.665 |
|
| 2007 |
Hu X, Wang H, Ke H, Kuhlman B. High-resolution design of a protein loop. Proceedings of the National Academy of Sciences of the United States of America. 104: 17668-73. PMID 17971437 DOI: 10.1073/Pnas.0707977104 |
0.619 |
|
| 2007 |
Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Molecular Microbiology. 66: 1029-38. PMID 17944832 DOI: 10.1111/J.1365-2958.2007.05976.X |
0.664 |
|
| 2007 |
Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. The Biochemical Journal. 408: 193-201. PMID 17727341 DOI: 10.1042/Bj20070970 |
0.676 |
|
| 2007 |
Wang H, Robinson H, Ke H. The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. Journal of Molecular Biology. 371: 302-7. PMID 17582435 DOI: 10.1016/J.Jmb.2007.05.060 |
0.641 |
|
| 2007 |
Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proceedings of the National Academy of Sciences of the United States of America. 104: 5782-7. PMID 17389385 DOI: 10.1073/Pnas.0700279104 |
0.664 |
|
| 2007 |
Ke H, Wang H. Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Current Topics in Medicinal Chemistry. 7: 391-403. PMID 17305581 DOI: 10.2174/156802607779941242 |
0.676 |
|
| 2007 |
Corbin J, Bessay EP, Blount MA, Zoraghi R, Morris GZ, Weeks JL, Ke H, Francis SH. Negative feedback control of the nitric oxide/cGMP pathway in smooth muscle Bmc Pharmacology. 7. DOI: 10.1186/1471-2210-7-S1-S30 |
0.325 |
|
| 2006 |
Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH. A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization. Molecular Pharmacology. 70: 1822-31. PMID 16926278 DOI: 10.1124/Mol.106.028688 |
0.353 |
|
| 2006 |
Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H. Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. The Journal of Biological Chemistry. 281: 21469-79. PMID 16735511 DOI: 10.1074/Jbc.M512527200 |
0.654 |
|
| 2006 |
Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y. Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. The Journal of Biological Chemistry. 281: 18463-72. PMID 16679321 DOI: 10.1074/Jbc.M602788200 |
0.304 |
|
| 2006 |
Huai Q, Sun Y, Wang H, Macdonald D, Aspiotis R, Robinson H, Huang Z, Ke H. Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. Journal of Medicinal Chemistry. 49: 1867-73. PMID 16539372 DOI: 10.1021/Jm051273D |
0.649 |
|
| 2005 |
Wang H, Liu Y, Chen Y, Robinson H, Ke H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. The Journal of Biological Chemistry. 280: 30949-55. PMID 15994308 DOI: 10.1074/Jbc.M504398200 |
0.653 |
|
| 2005 |
Huai Q, Wang H, Liu Y, Kim HY, Toft D, Ke H. Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure (London, England : 1993). 13: 579-90. PMID 15837196 DOI: 10.1016/J.Str.2004.12.018 |
0.635 |
|
| 2004 |
Huai Q, Wang H, Zhang W, Colman RW, Robinson H, Ke H. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Proceedings of the National Academy of Sciences of the United States of America. 101: 9624-9. PMID 15210993 DOI: 10.1073/Pnas.0401120101 |
0.67 |
|
| 2004 |
Huai Q, Liu Y, Francis SH, Corbin JD, Ke H. Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity. The Journal of Biological Chemistry. 279: 13095-101. PMID 14668322 DOI: 10.1074/Jbc.M311556200 |
0.449 |
|
| 2003 |
Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. Febs Letters. 549: 171-5. PMID 12914946 DOI: 10.1016/S0014-5793(03)00764-6 |
0.628 |
|
| 2003 |
Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H. Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. Structure (London, England : 1993). 11: 865-73. PMID 12842049 DOI: 10.1016/S0969-2126(03)00123-0 |
0.669 |
|
| 2002 |
Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 12037-42. PMID 12218175 DOI: 10.1073/Pnas.192206699 |
0.363 |
|
| 2001 |
Zhang W, Ke H, Tretiakova AP, Jameson B, Colman RW. Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B. Protein Science. 10: 1481-1489. PMID 11468344 DOI: 10.1110/Ps.6601 |
0.381 |
|
| 2001 |
Fox DS, Cruz MC, Sia RA, Ke H, Cox GM, Cardenas ME, Heitman J. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Molecular Microbiology. 39: 835-49. PMID 11251806 DOI: 10.1046/J.1365-2958.2001.02295.X |
0.303 |
|
| 2000 |
Huai Q, Colandene JD, Chen Y, Luo F, Zhao Y, Topal MD, Ke H. Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase. The Embo Journal. 19: 3110-8. PMID 10856254 DOI: 10.1093/Emboj/19.12.3110 |
0.317 |
|
| 2000 |
Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science (New York, N.Y.). 288: 1822-5. PMID 10846163 DOI: 10.1126/Science.288.5472.1822 |
0.37 |
|
| 1998 |
Chook YM, Lipscomb WN, Ke H. Detection and use of pseudo-translation in determination of protein structures. Acta Crystallographica. Section D, Biological Crystallography. 54: 822-7. PMID 9757096 DOI: 10.1107/S0907444997020064 |
0.313 |
|
| 1997 |
Zhao Y, Chen Y, Schutkowski M, Fischer G, Ke H. Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity. Structure. 5: 139-146. PMID 9016720 DOI: 10.1016/S0969-2126(97)00172-X |
0.313 |
|
| 1996 |
Mayrose DR, Nichols MA, Xiong Y, Ke H. Purification and crystallization of cyclin‐dependent kinase inhibitor p21 Protein Science. 5: 1928-1930. PMID 8880918 DOI: 10.1002/Pro.5560050920 |
0.312 |
|
| 1996 |
Zhao Y, Ke H. Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes Biochemistry. 35: 7362-7368. PMID 8652512 DOI: 10.1021/Bi960278X |
0.395 |
|
| 1996 |
Zhao Y, Ke H. Crystal structure implies that cyclophilin predominantly catalyzes the Trans to Cis isomerization Biochemistry. 35: 7356-7361. PMID 8652511 DOI: 10.1021/Bi9602775 |
0.337 |
|
| 1994 |
Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure (London, England : 1993). 2: 33-44. PMID 8075981 DOI: 10.1016/S0969-2126(00)00006-X |
0.387 |
|
| 1994 |
Chook YM, Gray JV, Ke H, Lipscomb WN. The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. Journal of Molecular Biology. 240: 476-500. PMID 8046752 DOI: 10.1006/Jmbi.1994.1462 |
0.381 |
|
| 1993 |
Ke H, Mayrose D, Cao W. Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization Proceedings of the National Academy of Sciences of the United States of America. 90: 3324-3328. PMID 8475075 DOI: 10.1073/Pnas.90.8.3324 |
0.334 |
|
| 1993 |
Chook YM, Ke H, Lipscomb WN. Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog. Proceedings of the National Academy of Sciences of the United States of America. 90: 8600-3. PMID 8378335 DOI: 10.1073/Pnas.90.18.8600 |
0.373 |
|
| 1993 |
Ke H, Zhao Y, Luo F, Weissman I, Friedman J. Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A Proceedings of the National Academy of Sciences of the United States of America. 90: 11850-11854. PMID 8265636 DOI: 10.1073/Pnas.90.24.11850 |
0.378 |
|
| 1992 |
Ke H. Similarities and differences between human cyclophilin A and other β-barrel structures. Structural refinement at 1.63 Å resolution Journal of Molecular Biology. 228: 539-550. PMID 1453463 DOI: 10.1016/0022-2836(92)90841-7 |
0.328 |
|
| 1992 |
Liang JY, Huang S, Zhang Y, Ke H, Lipscomb WN. Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 89: 2404-8. PMID 1312721 DOI: 10.1073/Pnas.89.6.2404 |
0.362 |
|
| 1991 |
Ke HM, Zydowsky LD, Liu J, Walsh CT. Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution. Proceedings of the National Academy of Sciences of the United States of America. 88: 9483-7. PMID 1946361 DOI: 10.1073/Pnas.88.21.9483 |
0.319 |
|
| 1984 |
Ke HM, Honzatko RB, Lipscomb WN. Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 81: 4037-40. PMID 6377306 DOI: 10.1073/Pnas.81.13.4037 |
0.358 |
|
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