Hengming Ke - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Biochemistry, General Biophysics, Molecular Biology

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Year Citation  Score
2020 Gupta R, Liu Y, Wang H, Nordyke CT, Puterbaugh RZ, Cui W, Varga K, Chu F, Ke H, Vashisth H, Cote RH. Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. Journal of Molecular Biology. PMID 32898583 DOI: 10.1016/J.Jmb.2020.08.026  0.638
2020 Zhang T, Lai Z, Yuan S, Huang YY, Dong G, Sheng C, Ke H, Luo HB. Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket. Journal of Medicinal Chemistry. PMID 32794708 DOI: 10.1021/Acs.Jmedchem.0C00983  0.408
2018 Yao T, Huang Y, Zhang M, Chen Y, Pei H, Shi J, Wang H, Wang Y, Ke H. Crystal structures of Candida albicans phosphodiesterase-2 and implication on its biological functions. Biochemistry. PMID 30231198 DOI: 10.1021/Acs.Biochem.8B00707  0.661
2018 Feng X, Wang H, Ye M, Xu XT, Xu Y, Yang W, Zhang H, Song G, Ke H. Identification of a PDE4-specific pocket for design of selective inhibitors. Biochemistry. PMID 29975048 DOI: 10.1021/Acs.Biochem.8B00336  0.656
2016 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Banerjee A, Bellwied R, ... ... Ke HW, et al. Measurement of the Transverse Single-Spin Asymmetry in p^{↑}+p→W^{±}/Z^{0} at RHIC. Physical Review Letters. 116: 132301. PMID 27081970 DOI: 10.1103/Physrevlett.116.132301  0.554
2016 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Bellwied R, Bhasin A, ... ... Ke HW, et al. Beam Energy Dependence of the Third Harmonic of Azimuthal Correlations in Au+Au Collisions at RHIC. Physical Review Letters. 116: 112302. PMID 27035295 DOI: 10.1103/Physrevlett.116.112302  0.564
2016 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Bairathi V, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Centrality and Transverse Momentum Dependence of Elliptic Flow of Multistrange Hadrons and ϕ Meson in Au+Au Collisions at sqrt[s_{NN}]=200  GeV. Physical Review Letters. 116: 062301. PMID 26918982 DOI: 10.1103/Physrevlett.116.062301  0.58
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in p^{↑}+p at sqrt[s]=200  GeV. Physical Review Letters. 115: 242501. PMID 26705627 DOI: 10.1103/Physrevlett.115.242501  0.552
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Azimuthal Anisotropy in U+U and Au+Au Collisions at RHIC. Physical Review Letters. 115: 222301. PMID 26650297 DOI: 10.1103/Physrevlett.115.222301  0.568
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Precision Measurement of the Longitudinal Double-Spin Asymmetry for Inclusive Jet Production in Polarized Proton Collisions at sqrt[s]=200  GeV. Physical Review Letters. 115: 092002. PMID 26371644 DOI: 10.1103/Physrevlett.115.092002  0.54
2015 Huang M, Shao Y, Hou J, Cai W, Liang B, Huang Y, Li Z, Wu Y, Zhu X, Liu P, Wan Y, Ke H, Luo HB. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Molecular Pharmacology. PMID 26316540 DOI: 10.1124/Mol.115.099747  0.374
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Ke HW, et al. Observation of Charge Asymmetry Dependence of Pion Elliptic Flow and the Possible Chiral Magnetic Wave in Heavy-Ion Collisions. Physical Review Letters. 114: 252302. PMID 26197122 DOI: 10.1103/Physrevlett.114.252302  0.555
2015 Leslie PL, Ke H, Zhang Y. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. The Journal of Biological Chemistry. 290: 12941-50. PMID 25809483 DOI: 10.1074/Jbc.M115.644435  0.347
2015 Li J, Wang H, Ke H, Ni S. MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 36: 5785-90. PMID 25716201 DOI: 10.1007/s13277-015-3247-z  0.518
2015 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. ΛΛ Correlation function in Au+Au collisions at √[S(NN)]=200  GeV. Physical Review Letters. 114: 022301. PMID 25635541 DOI: 10.1103/Physrevlett.114.022301  0.554
2015 Chen XH, Liu ZC, Zhang G, Wei W, Wang XX, Wang H, Ke HP, Zhang F, Wang HS, Cai SH, Du J. TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. Molecular Immunology. 65: 34-42. PMID 25618241 DOI: 10.1016/J.Molimm.2014.12.017  0.497
2014 Shao YX, Huang M, Cui W, Feng LJ, Wu Y, Cai Y, Li Z, Zhu X, Liu P, Wan Y, Ke H, Luo HB. Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent. Journal of Medicinal Chemistry. 57: 10304-13. PMID 25432025 DOI: 10.1021/Jm500836H  0.319
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Observation of D0 meson nuclear modifications in Au+Au collisions at sqrt[s(NN)] = 200 GeV. Physical Review Letters. 113: 142301. PMID 25325635 DOI: 10.1103/Physrevlett.113.142301  0.561
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Beam energy dependence of moments of the net-charge multiplicity distributions in Au+Au collisions at RHIC. Physical Review Letters. 113: 092301. PMID 25215979 DOI: 10.1103/Physrevlett.113.092301  0.549
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Beavis DR, ... ... Ke HW, et al. Measurement of longitudinal spin asymmetries for weak boson production in polarized proton-proton collisions at RHIC. Physical Review Letters. 113: 072301. PMID 25170701 DOI: 10.1103/Physrevlett.113.072301  0.544
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Beam-energy dependence of charge separation along the magnetic field in Au+Au collisions at RHIC. Physical Review Letters. 113: 052302. PMID 25126911 DOI: 10.1103/Physrevlett.113.052302  0.559
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Barnovska Z, Beavis DR, ... ... Ke HW, et al. Dielectron mass spectra from Au+Au collisions at √[s(NN)]=200  GeV. Physical Review Letters. 113: 022301. PMID 25062167 DOI: 10.1103/Physrevlett.113.022301  0.559
2014 Tian Y, Cui W, Huang M, Robinson H, Wan Y, Wang Y, Ke H. Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Biochemistry. 53: 4938-45. PMID 25050706 DOI: 10.1021/Bi500406H  0.387
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Beam-energy dependence of the directed flow of protons, antiprotons, and pions in Au+Au collisions. Physical Review Letters. 112: 162301. PMID 24815640 DOI: 10.1103/Physrevlett.112.162301  0.567
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Ke HW, et al. Jet-hadron correlations in √[s(NN)]=200  GeV p+p and central Au+Au collisions. Physical Review Letters. 112: 122301. PMID 24724645 DOI: 10.1103/Physrevlett.112.122301  0.556
2014 Shang NN, Shao YX, Cai YH, Guan M, Huang M, Cui W, He L, Yu YJ, Huang L, Li Z, Bu XZ, Ke H, Luo HB. Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochemical Pharmacology. 89: 86-98. PMID 24565909 DOI: 10.1016/J.Bcp.2014.02.013  0.421
2014 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Energy dependence of moments of net-proton multiplicity distributions at RHIC. Physical Review Letters. 112: 032302. PMID 24484135 DOI: 10.1103/Physrevlett.112.032302  0.564
2013 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Observation of an energy-dependent difference in elliptic flow between particles and antiparticles in relativistic heavy ion collisions. Physical Review Letters. 110: 142301. PMID 25166982 DOI: 10.1103/Physrevlett.110.142301  0.55
2013 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Ke HW, et al. Measurement of J/ψ azimuthal anisotropy in Au+Au collisions at sqrt[s(NN)]=200 GeV. Physical Review Letters. 111: 052301. PMID 23952389 DOI: 10.1103/Physrevlett.111.052301  0.56
2013 Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. Journal of Medicinal Chemistry. 56: 2087-96. PMID 23409953 DOI: 10.1021/Jm3017877  0.646
2013 Wang H, Ke H, Lin SY, Guo Y, Zhao L, Tang J, Li YH. Heterometallic octanuclear RE(III)3Ni(II)5 (RE = Dy(III), Gd(III) and Y(III)) clusters with slow magnetic relaxation for the dysprosium derivative. Dalton Transactions (Cambridge, England : 2003). 42: 5298-303. PMID 23403627 DOI: 10.1039/c3dt32572e  0.527
2012 Adamczyk L, Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Banerjee A, Barnovska Z, Beavis DR, ... ... Ke HW, et al. Directed flow of identified particles in Au+Au collisions at √[SNN]=200  GeV at RHIC. Physical Review Letters. 108: 202301. PMID 23003142 DOI: 10.1103/Physrevlett.108.202301  0.564
2012 Meng F, Hou J, Shao YX, Wu PY, Huang M, Zhu X, Cai Y, Li Z, Xu J, Liu P, Luo HB, Wan Y, Ke H. Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design. Journal of Medicinal Chemistry. 55: 8549-58. PMID 22985069 DOI: 10.1021/Jm301189C  0.405
2012 Chen HL, Chen YC, Lu MY, Chang JJ, Wang HT, Ke HM, Wang TY, Ruan SK, Wang TY, Hung KY, Cho HY, Lin WT, Shih MC, Li WH. A highly efficient β-glucosidase from the buffalo rumen fungus Neocallimastix patriciarum W5. Biotechnology For Biofuels. 5: 24. PMID 22515264 DOI: 10.1186/1754-6834-5-24  0.554
2012 Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Bellwied R, Betancourt MJ, ... ... Ke HW, et al. Identified hadron compositions in p+p and Au+Au collisions at high transverse momenta at √S(NN)=200 GeV. Physical Review Letters. 108: 072302. PMID 22401197 DOI: 10.1103/Physrevlett.108.072302  0.54
2012 Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Behera NK, Bellwied R, ... ... Ke HW, et al. Strangeness enhancement in Cu-Cu and Au-Au collisions at √S(NN)=200 GeV. Physical Review Letters. 108: 072301. PMID 22401196 DOI: 10.1103/Physrevlett.108.072301  0.526
2012 Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, Martinelli S, Ke H. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of Biological Chemistry. 287: 11788-97. PMID 22356915 DOI: 10.1074/Jbc.M111.326777  0.67
2011 Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, ... ... Ke H, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147: 223-34. PMID 21962518 DOI: 10.1016/J.Cell.2011.08.037  0.609
2011 Chou YH, Li CC, Hsu H, Chang WC, Liu CC, Li WM, Ke HL, Lee MH, Liu ME, Pan SC, Wang HS. Renal function in patients with urinary stones of varying compositions. The Kaohsiung Journal of Medical Sciences. 27: 264-7. PMID 21757143 DOI: 10.1016/j.kjms.2010.11.008  0.495
2011 Ke H, Wang H, Ye M. Structural insight into the substrate specificity of phosphodiesterases. Handbook of Experimental Pharmacology. 121-34. PMID 21695637 DOI: 10.1007/978-3-642-17969-3_4  0.657
2011 Hou J, Xu J, Liu M, Zhao R, Luo HB, Ke H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine. Plos One. 6: e18092. PMID 21483814 DOI: 10.1371/Journal.Pone.0018092  0.433
2011 Francis SH, Sekhar KR, Ke H, Corbin JD. Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds. Handbook of Experimental Pharmacology. 93-133. PMID 20859794 DOI: 10.1007/978-3-642-13443-2_4  0.322
2010 Wang H, Robinson H, Ke H. Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. The Journal of Biological Chemistry. 285: 38149-56. PMID 20861010 DOI: 10.1074/Jbc.M110.141614  0.628
2010 Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, Lee AL. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry. 49: 9280-91. PMID 20839809 DOI: 10.1021/Bi101131F  0.61
2010 Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis. Journal of Medicinal Chemistry. 53: 1726-31. PMID 20121115 DOI: 10.1021/Jm901519F  0.656
2009 Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, Wang H, Ke H, Nikolaev VO, Jaffe LA. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (Cambridge, England). 136: 1869-78. PMID 19429786 DOI: 10.1242/Dev.035238  0.571
2009 Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H, Gil C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. Chemmedchem. 4: 866-76. PMID 19350606 DOI: 10.1002/Cmdc.200900043  0.605
2009 Yan Z, Wang H, Cai J, Ke H. Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain. Protein Expression and Purification. 64: 82-8. PMID 18984055 DOI: 10.1016/J.Pep.2008.10.005  0.609
2008 Hu X, Wang H, Ke H, Kuhlman B. Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design. Structure (London, England : 1993). 16: 1799-805. PMID 19081056 DOI: 10.1016/J.Str.2008.09.013  0.571
2008 Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H. Design, synthesis, and structure - Activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors Journal of Medicinal Chemistry. 51: 7673-7688. PMID 19049349 DOI: 10.1021/Jm701635J  0.598
2008 Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry. 47: 12760-8. PMID 18983167 DOI: 10.1021/Bi801487X  0.669
2008 Chen G, Wang H, Robinson H, Cai J, Wan Y, Ke H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies. Biochemical Pharmacology. 75: 1717-28. PMID 18346713 DOI: 10.1016/J.Bcp.2008.01.019  0.667
2008 Wang H, Ye M, Robinson H, Francis SH, Ke H. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Molecular Pharmacology. 73: 104-10. PMID 17959709 DOI: 10.1124/Mol.107.040212  0.664
2007 Hu X, Wang H, Ke H, Kuhlman B. High-resolution design of a protein loop. Proceedings of the National Academy of Sciences of the United States of America. 104: 17668-73. PMID 17971437 DOI: 10.1073/Pnas.0707977104  0.618
2007 Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Molecular Microbiology. 66: 1029-38. PMID 17944832 DOI: 10.1111/J.1365-2958.2007.05976.X  0.663
2007 Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. The Biochemical Journal. 408: 193-201. PMID 17727341 DOI: 10.1042/Bj20070970  0.675
2007 Wang H, Robinson H, Ke H. The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. Journal of Molecular Biology. 371: 302-7. PMID 17582435 DOI: 10.1016/J.Jmb.2007.05.060  0.64
2007 Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proceedings of the National Academy of Sciences of the United States of America. 104: 5782-7. PMID 17389385 DOI: 10.1073/Pnas.0700279104  0.663
2007 Ke H, Wang H. Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Current Topics in Medicinal Chemistry. 7: 391-403. PMID 17305581 DOI: 10.2174/156802607779941242  0.675
2007 Corbin J, Bessay EP, Blount MA, Zoraghi R, Morris GZ, Weeks JL, Ke H, Francis SH. Negative feedback control of the nitric oxide/cGMP pathway in smooth muscle Bmc Pharmacology. 7. DOI: 10.1186/1471-2210-7-S1-S30  0.325
2006 Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH. A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization. Molecular Pharmacology. 70: 1822-31. PMID 16926278 DOI: 10.1124/Mol.106.028688  0.353
2006 Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H. Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. The Journal of Biological Chemistry. 281: 21469-79. PMID 16735511 DOI: 10.1074/Jbc.M512527200  0.653
2006 Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y. Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. The Journal of Biological Chemistry. 281: 18463-72. PMID 16679321 DOI: 10.1074/Jbc.M602788200  0.304
2006 Huai Q, Sun Y, Wang H, Macdonald D, Aspiotis R, Robinson H, Huang Z, Ke H. Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. Journal of Medicinal Chemistry. 49: 1867-73. PMID 16539372 DOI: 10.1021/Jm051273D  0.648
2005 Wang H, Liu Y, Chen Y, Robinson H, Ke H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. The Journal of Biological Chemistry. 280: 30949-55. PMID 15994308 DOI: 10.1074/Jbc.M504398200  0.652
2005 Huai Q, Wang H, Liu Y, Kim HY, Toft D, Ke H. Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure (London, England : 1993). 13: 579-90. PMID 15837196 DOI: 10.1016/J.Str.2004.12.018  0.633
2004 Huai Q, Wang H, Zhang W, Colman RW, Robinson H, Ke H. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Proceedings of the National Academy of Sciences of the United States of America. 101: 9624-9. PMID 15210993 DOI: 10.1073/Pnas.0401120101  0.669
2004 Huai Q, Liu Y, Francis SH, Corbin JD, Ke H. Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity. The Journal of Biological Chemistry. 279: 13095-101. PMID 14668322 DOI: 10.1074/Jbc.M311556200  0.449
2003 Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. Febs Letters. 549: 171-5. PMID 12914946 DOI: 10.1016/S0014-5793(03)00764-6  0.627
2003 Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H. Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. Structure (London, England : 1993). 11: 865-73. PMID 12842049 DOI: 10.1016/S0969-2126(03)00123-0  0.667
2002 Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 12037-42. PMID 12218175 DOI: 10.1073/Pnas.192206699  0.363
2001 Zhang W, Ke H, Tretiakova AP, Jameson B, Colman RW. Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B. Protein Science. 10: 1481-1489. PMID 11468344 DOI: 10.1110/Ps.6601  0.381
2001 Fox DS, Cruz MC, Sia RA, Ke H, Cox GM, Cardenas ME, Heitman J. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Molecular Microbiology. 39: 835-49. PMID 11251806 DOI: 10.1046/J.1365-2958.2001.02295.X  0.303
2000 Huai Q, Colandene JD, Chen Y, Luo F, Zhao Y, Topal MD, Ke H. Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase. The Embo Journal. 19: 3110-8. PMID 10856254 DOI: 10.1093/Emboj/19.12.3110  0.317
2000 Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science (New York, N.Y.). 288: 1822-5. PMID 10846163 DOI: 10.1126/Science.288.5472.1822  0.37
1998 Chook YM, Lipscomb WN, Ke H. Detection and use of pseudo-translation in determination of protein structures. Acta Crystallographica. Section D, Biological Crystallography. 54: 822-7. PMID 9757096 DOI: 10.1107/S0907444997020064  0.313
1997 Zhao Y, Chen Y, Schutkowski M, Fischer G, Ke H. Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity. Structure. 5: 139-146. PMID 9016720 DOI: 10.1016/S0969-2126(97)00172-X  0.313
1996 Mayrose DR, Nichols MA, Xiong Y, Ke H. Purification and crystallization of cyclin‐dependent kinase inhibitor p21 Protein Science. 5: 1928-1930. PMID 8880918 DOI: 10.1002/Pro.5560050920  0.312
1996 Zhao Y, Ke H. Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes Biochemistry. 35: 7362-7368. PMID 8652512 DOI: 10.1021/Bi960278X  0.395
1996 Zhao Y, Ke H. Crystal structure implies that cyclophilin predominantly catalyzes the Trans to Cis isomerization Biochemistry. 35: 7356-7361. PMID 8652511 DOI: 10.1021/Bi9602775  0.337
1994 Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure (London, England : 1993). 2: 33-44. PMID 8075981 DOI: 10.1016/S0969-2126(00)00006-X  0.387
1994 Chook YM, Gray JV, Ke H, Lipscomb WN. The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. Journal of Molecular Biology. 240: 476-500. PMID 8046752 DOI: 10.1006/Jmbi.1994.1462  0.381
1993 Ke H, Mayrose D, Cao W. Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization Proceedings of the National Academy of Sciences of the United States of America. 90: 3324-3328. PMID 8475075 DOI: 10.1073/Pnas.90.8.3324  0.334
1993 Chook YM, Ke H, Lipscomb WN. Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog. Proceedings of the National Academy of Sciences of the United States of America. 90: 8600-3. PMID 8378335 DOI: 10.1073/Pnas.90.18.8600  0.373
1993 Ke H, Zhao Y, Luo F, Weissman I, Friedman J. Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A Proceedings of the National Academy of Sciences of the United States of America. 90: 11850-11854. PMID 8265636 DOI: 10.1073/Pnas.90.24.11850  0.378
1992 Ke H. Similarities and differences between human cyclophilin A and other β-barrel structures. Structural refinement at 1.63 Å resolution Journal of Molecular Biology. 228: 539-550. PMID 1453463 DOI: 10.1016/0022-2836(92)90841-7  0.328
1992 Liang JY, Huang S, Zhang Y, Ke H, Lipscomb WN. Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 89: 2404-8. PMID 1312721 DOI: 10.1073/Pnas.89.6.2404  0.362
1991 Ke HM, Zydowsky LD, Liu J, Walsh CT. Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution. Proceedings of the National Academy of Sciences of the United States of America. 88: 9483-7. PMID 1946361 DOI: 10.1073/Pnas.88.21.9483  0.319
1984 Ke HM, Honzatko RB, Lipscomb WN. Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 81: 4037-40. PMID 6377306 DOI: 10.1073/Pnas.81.13.4037  0.358
Low-probability matches (unlikely to be authored by this person)
2011 Seebeck T, Sterk GJ, Ke H. Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite. Future Medicinal Chemistry. 3: 1289-306. PMID 21859303 DOI: 10.4155/Fmc.11.77  0.299
2019 Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Immunity. 50: 591-599.e6. PMID 30893587 DOI: 10.1016/J.Immuni.2019.02.009  0.295
2020 Peng T, Qi B, He J, Ke H, Shi J. Advances in the development of phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry. PMID 32255344 DOI: 10.1021/Acs.Jmedchem.9B02170  0.294
2014 Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. Advances in targeting cyclic nucleotide phosphodiesterases. Nature Reviews. Drug Discovery. 13: 290-314. PMID 24687066 DOI: 10.1038/Nrd4228  0.293
2002 Dym O, Xenarios I, Ke H, Colicelli J. Molecular docking of competitive phosphodiesterase inhibitors. Molecular Pharmacology. 61: 20-5. PMID 11752202 DOI: 10.1124/Mol.61.1.20  0.291
2004 Olzmann JA, Brown K, Wilkinson KD, Rees HD, Huai Q, Ke H, Levey AI, Li L, Chin LS. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. The Journal of Biological Chemistry. 279: 8506-15. PMID 14665635 DOI: 10.1074/Jbc.M311017200  0.288
2019 Zhu C, Dukhovlinova E, Council O, Ping L, Faison EM, Prabhu SS, Potter EL, Upton SL, Yin G, Fay JM, Kincer LP, Spielvogel E, Campbell SL, Benhabbour SR, Ke H, et al. Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies. Nature Communications. 10: 948. PMID 30814513 DOI: 10.1038/S41467-019-08876-W  0.281
2020 Zhu MJ, Shi J, Chen Y, Huang G, Zhu XW, Zhang S, Huang XF, Song GQ, Zhang HT, Ke HM, O'Donnell JM, Wang LQ, Xu Y. Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior. Psychopharmacology. PMID 32926224 DOI: 10.1007/S00213-019-05401-1  0.28
2017 Wang Y, Ke H. A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS. Advances in Neurobiology. 17: 463-471. PMID 28956343 DOI: 10.1007/978-3-319-58811-7_17  0.276
2003 Huai Q, Colicelli J, Ke H. The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis. Biochemistry. 42: 13220-6. PMID 14609333 DOI: 10.1021/Bi034653E  0.276
2001 Huai Q, Colandene JD, Topal MD, Ke H. Structure of NaeI-DNA complex reveals dual-mode DNA recognition and complete dimer rearrangement. Nature Structural Biology. 8: 665-9. PMID 11473254 DOI: 10.1038/90366  0.271
2011 Shakur Y, de Koning HP, Ke H, Kambayashi J, Seebeck T. Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases. Handbook of Experimental Pharmacology. 487-510. PMID 21695653 DOI: 10.1007/978-3-642-17969-3_20  0.258
2012 Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 148: 421-33. PMID 22304913 DOI: 10.1016/J.Cell.2012.01.017  0.254
2017 Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH. Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. Ebiomedicine. PMID 28396013 DOI: 10.1016/J.Ebiom.2017.03.019  0.251
2003 Ke H, Huai Q. Structures of calcineurin and its complexes with immunophilins-immunosuppressants. Biochemical and Biophysical Research Communications. 311: 1095-102. PMID 14623295 DOI: 10.1016/S0006-291X(03)01537-7  0.249
2016 Fay JM, Zhu C, Proctor EA, Tao Y, Cui W, Ke H, Dokholyan NV. A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation. Structure (London, England : 1993). PMID 27667694 DOI: 10.1016/J.Str.2016.08.011  0.235
2018 Huang XF, Cao YJ, Zhen J, Zhang DW, Kong R, Jiang WT, Xu Y, Song GQ, Ke HM, Liu L. Design, synthesis of novel purin-6-one derivatives as phosphodiesterase 2 (PDE2) inhibitors: The neuroprotective and anxiolytic-like effects. Bioorganic & Medicinal Chemistry Letters. PMID 30554955 DOI: 10.1016/j.bmcl.2018.12.018  0.229
2020 Huang XF, Dong YH, Wang JH, Ke HM, Song GQ, Xu DF. Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 127097. PMID 32171616 DOI: 10.1016/j.bmcl.2020.127097  0.217
2018 Huang XF, Jiang WT, Liu L, Song FC, Zhu X, Shi GL, Ding SM, Ke HM, Wang W, O'Donnell JM, Zhang HT, Luo HB, Wan YQ, Song GQ, Xu Y. A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling. Cns Neuroscience & Therapeutics. PMID 29722134 DOI: 10.1111/Cns.12864  0.214
2009 Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, Wang H, Ke H, Nikolaev VO, Jaffe LA. Cyclic GMP from the somatic cells of the mouse ovarian follicle regulates cyclic AMP and meiosis in the oocyte Developmental Biology. 331: 419. DOI: 10.1016/J.Ydbio.2009.05.115  0.211
2005 Ke H, Huai Q, Xu RX. Crystallization of cyclic nucleotide phosphodiesterases. Methods in Molecular Biology (Clifton, N.J.). 307: 181-90. PMID 15988064 DOI: 10.1385/1-59259-839-0:181  0.199
2004 Ke H, Huai Q. Crystal structures of cyclophilin and its partners. Frontiers in Bioscience : a Journal and Virtual Library. 9: 2285-96. PMID 15353287  0.193
2017 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Attri A, Averichev GS, Bai X, ... ... Ke HW, et al. Dijet imbalance measurements in Au+Au and pp collisions at sqrt[s_{NN}]=200  GeV at STAR. Physical Review Letters. 119: 062301. PMID 28949601 DOI: 10.1103/Physrevlett.119.062301  0.186
2018 Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Ajitanand NN, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Attri A, ... ... Ke HW, et al. Beam Energy Dependence of Jet-Quenching Effects in Au+Au Collisions at sqrt[s_{NN}]=7.7, 11.5, 14.5, 19.6, 27, 39, and 62.4 GeV. Physical Review Letters. 121: 032301. PMID 30085817 DOI: 10.1103/Physrevlett.121.032301  0.185
1999 Ke H, Zhao Y, Chen Y, Schutkowski M, Fischer G. Is the cis-trans isomerization of cyclophilin involved in HIV-1 infectivity? Collection of Czechoslovak Chemical Communications. 1: 187-193. DOI: 10.1135/Css199901187  0.18
2024 Xiang Y, Naik S, Zhao L, Shi J, Ke H. Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases. Medicinal Research Reviews. PMID 38279990 DOI: 10.1002/med.22017  0.175
2018 Adam J, Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Ajitanand NN, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, ... ... Ke HW, et al. Low-p_{T} e^{+}e^{-} Pair Production in Au+Au Collisions at sqrt[s_{NN}]=200  GeV and U+U Collisions at sqrt[s_{NN}]=193  GeV at STAR. Physical Review Letters. 121: 132301. PMID 30312102 DOI: 10.1103/Physrevlett.121.132301  0.173
2012 Yuan Q, He L, Ke H. A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activity. Antimicrobial Agents and Chemotherapy. 56: 5157-63. PMID 22825119 DOI: 10.1128/AAC.05896-11  0.172
2017 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Ajitanand NN, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Attri A, Averichev GS, ... ... Ke HW, et al. Measurement of D^{0} Azimuthal Anisotropy at Midrapidity in Au+Au Collisions at sqrt[s_{NN}]=200  GeV. Physical Review Letters. 118: 212301. PMID 28598664 DOI: 10.1103/Physrevlett.118.212301  0.16
2019 Adam J, Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Atetalla F, ... ... Ke HW, et al. Polarization of Λ (Λ[over ¯]) Hyperons along the Beam Direction in Au+Au Collisions at sqrt[s_{NN}]=200  GeV. Physical Review Letters. 123: 132301. PMID 31697517 DOI: 10.1103/Physrevlett.123.132301  0.154
2009 Itahana Y, Ke H, Zhang Y. p53 Oligomerization is essential for its C-terminal lysine acetylation. The Journal of Biological Chemistry. 284: 5158-64. PMID 19106109 DOI: 10.1074/Jbc.M805696200  0.149
2019 Adam J, Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Atetalla F, ... ... Ke HW, et al. Azimuthal Harmonics in Small and Large Collision Systems at RHIC Top Energies. Physical Review Letters. 122: 172301. PMID 31107064 DOI: 10.1103/Physrevlett.122.172301  0.145
2020 Adam J, Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aparin A, Aschenauer EC, Ashraf MU, Atetalla FG, Attri A, Averichev GS, ... ... Ke HW, et al. First Measurement of Λ_{c} Baryon Production in Au+Au Collisions at sqrt[s_{NN}]=200  GeV. Physical Review Letters. 124: 172301. PMID 32412276 DOI: 10.1103/Physrevlett.124.172301  0.144
2019 Adam J, Adamczyk L, Adams JR, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aoyama R, Aparin A, Aschenauer EC, Ashraf MU, Atetalla FG, Attri A, ... ... Ke HW, et al. First Observation of the Directed Flow of D^{0} and D^{0}[over ¯] in Au+Au Collisions at sqrt[s_{NN}]=200  GeV. Physical Review Letters. 123: 162301. PMID 31702332 DOI: 10.1103/Physrevlett.123.162301  0.141
2018 Liu L, Zheng J, Huang XF, Zhu X, Ding SM, Ke HM, O'Donnell JM, Zhang HT, Song GQ, Xu Y. The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor. Cns Neuroscience & Therapeutics. PMID 29704309 DOI: 10.1111/Cns.12863  0.112
2019 Peng H, Meyer RS, Yang T, Whitaker BD, Trouth F, Shangguan L, Huang J, Litt A, Little DP, Ke H, Jurick WM. A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants. Bmc Plant Biology. 19: 261. PMID 31208339 DOI: 10.1186/S12870-019-1846-3  0.045
1997 Ke H. [25] Overview of isomorphous replacement phasing. Methods in Enzymology. 276: 448-461. PMID 27799108 DOI: 10.1016/S0076-6879(97)76071-3  0.012
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