Philipp E. Scherer - Publications

Yeshiva University, New York, NY, United States 
Molecular Biology, General Biophysics

195 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Frankl J, Sherwood A, Clegg DJ, Scherer PE, Öz OK. Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights. International Journal of Molecular Sciences. 20. PMID 31694216 DOI: 10.3390/ijms20215509  0.44
2019 Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, ... ... Scherer PE, et al. Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. The Journal of Clinical Investigation. PMID 31573981 DOI: 10.1172/JCI129167  0.4
2019 Shao M, Wang QA, Song A, Vishvanath L, Busbuso NC, Scherer PE, Gupta RK. Cellular Origins of Beige Fat Cells Revisited. Diabetes. 68: 1874-1885. PMID 31540940 DOI: 10.2337/db19-0308  0.48
2019 Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben A, Wang MY, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, ... ... Scherer PE, et al. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice. The Journal of Clinical Investigation. PMID 31503545 DOI: 10.1172/JCI130239  0.48
2019 Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, ... ... Scherer PE, et al. Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metabolism. PMID 31495688 DOI: 10.1016/j.cmet.2019.08.005  0.76
2019 Kusminski CM, Scherer PE. Lowering ceramides to overcome diabetes. Science (New York, N.Y.). 365: 319-320. PMID 31346052 DOI: 10.1126/science.aax6594  0.32
2019 Crewe C, Zhu Y, Paschoal VA, Joffin N, Ghaben AL, Gordillo R, Oh DY, Liang G, Horton JD, Scherer PE. SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1. Jci Insight. 5. PMID 31310592 DOI: 10.1172/jci.insight.129397  0.36
2019 Caron A, Reynolds RP, Castorena CM, Michael NJ, Lee CE, Lee S, Berdeaux R, Scherer PE, Elmquist JK. Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis. Molecular Metabolism. PMID 31279640 DOI: 10.1016/j.molmet.2019.06.019  0.32
2019 Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Luo X, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, et al. Spliced X-Box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR. Circulation. PMID 31177839 DOI: 10.1161/CIRCULATIONAHA.118.038924  0.52
2019 Gliniak CM, Scherer PE. Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood. The Journal of Clinical Investigation. 130. PMID 31081800 DOI: 10.1172/JCI128830  0.4
2019 Bu D, Crewe C, Kusminski CM, Gordillo R, Ghaben AL, Kim M, Park J, Deng H, Xiong W, Liu XZ, Lønning PE, Halberg N, Rios A, Chang Y, Gonzalez A, ... ... Scherer PE, et al. Human endotrophin as a driver of malignant tumor growth. Jci Insight. 5. PMID 30896449 DOI: 10.1172/jci.insight.125094  0.76
2019 Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. Vascular Endothelial Growth Factor-D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity. The American Journal of Pathology. PMID 30878136 DOI: 10.1016/j.ajpath.2018.12.008  0.44
2019 Ye R, Onodera T, Scherer PE. Lipotoxicity and Cell Maintenance in Obesity and Type 2 Diabetes. Journal of the Endocrine Society. 3: 617-631. PMID 30834357 DOI: 10.1210/js.2018-00372  0.32
2019 Ye R, Onodera T, Blanchard PG, Kusminski CM, Esser V, Brekken RA, Scherer PE. β1 syntrophin supports autophagy initiation and protects against cerulein-induced acute pancreatitis. The American Journal of Pathology. PMID 30653956 DOI: 10.1016/j.ajpath.2019.01.002  0.32
2019 Peri-Okonny PA, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, ... ... Scherer PE, et al. High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice. Circulation. PMID 30612451 DOI: 10.1161/CIRCULATIONAHA.118.037550  0.32
2018 Joffin N, Scherer PE. Reduced oxygen consumption by fat cells improves metabolic defects. Nature. 564: 47-48. PMID 30510226 DOI: 10.1038/d41586-018-07248-6  0.36
2018 Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State. Cell. PMID 30293865 DOI: 10.1016/j.cell.2018.09.005  0.76
2018 Lee C, Kim M, Lee JH, Oh J, Shin HH, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J. COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease. The Journal of Pathology. PMID 30246318 DOI: 10.1002/path.5172  0.76
2018 Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer PE. Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. Cell Metabolism. PMID 29909970 DOI: 10.1016/j.cmet.2018.05.022  0.48
2018 Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK. Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease. Molecular Metabolism. PMID 29884546 DOI: 10.1016/j.molmet.2018.05.015  0.32
2018 Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV. Glucose-regulated protein 78 is essential for cardiac myocyte survival. Cell Death and Differentiation. PMID 29666470 DOI: 10.1038/s41418-018-0109-4  0.52
2018 Kusminski CM, Scherer PE. New zoning laws enforced by glucagon. Proceedings of the National Academy of Sciences of the United States of America. 115: 4308-4310. PMID 29632201 DOI: 10.1073/pnas.1804203115  0.32
2018 Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M. Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis. Diabetes Care. PMID 29602794 DOI: 10.2337/dc17-1318  0.36
2018 Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar P, Gupta RK, Horton JD, Hill JA, Scherer PE. Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. Molecular Metabolism. PMID 29551634 DOI: 10.1016/j.molmet.2018.02.013  1
2018 Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE. PPARγ and its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization. Molecular and Cellular Biology. PMID 29483301 DOI: 10.1128/MCB.00677-17  0.4
2018 Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, ... ... Scherer PE, et al. Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. The Journal of Clinical Investigation. PMID 29457786 DOI: 10.1172/JCI97702  0.44
2018 Zhang F, Hao G, Shao M, Nham K, An Y, Wang Q, Zhu Y, Kusminski CM, Hassan G, Gupta RK, Zhai Q, Sun X, Scherer PE, Oz OK. An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. Cell Metabolism. 27: 252-262.e3. PMID 29320705 DOI: 10.1016/j.cmet.2017.12.004  0.4
2017 Wilson RJ, Drake JC, Cui D, Zhang M, Perry HM, Kashatus JA, Kusminski CM, Scherer PE, Kashatus DF, Okusa MD, Yan Z. Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy. Mitochondrion. PMID 29274400 DOI: 10.1016/j.mito.2017.12.008  0.32
2017 Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE. Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. Diabetologia. PMID 29224189 DOI: 10.1007/s00125-017-4516-8  0.76
2017 Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. Nav1.8 neurons are involved in limiting acute phase responses to dietary fat. Molecular Metabolism. 6: 1081-1091. PMID 29031710 DOI: 10.1016/j.molmet.2017.07.012  0.36
2017 Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, ... ... Scherer PE, et al. Hepatic GALE Regulates Whole Body Glucose Homeostasis by Modulating Tff3 Expression. Diabetes. PMID 28877911 DOI: 10.2337/db17-0323  0.4
2017 Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. The American Journal of Pathology. PMID 28683257 DOI: 10.1016/j.ajpath.2017.05.009  0.36
2017 Wang MY, Yu X, Lee Y, McCorkle SK, Chen S, Li J, Wang ZV, Davidson JA, Scherer PE, Holland WL, Unger RH, Roth MG. Dapagliflozin suppresses glucagon signaling in rodent models of diabetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584109 DOI: 10.1073/pnas.1705845114  0.52
2017 Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell T, Bisetto S, Velasco-Velàzquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, ... ... Scherer PE, et al. Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis. Cancer Research. PMID 28522753 DOI: 10.1158/0008-5472.CAN-16-0425  0.32
2017 An YA, Sun K, Joffin N, Zhang F, Deng Y, Donzé O, Kusminski CM, Scherer PE. Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis. Elife. 6. PMID 28355132 DOI: 10.7554/eLife.24071  0.76
2017 Tao C, Holland WL, Wang QA, Shao M, Jia L, Sun K, Lin X, Kuo YC, Johnson JA, Gordillo R, Elmquist JK, Scherer PE. Short-Term vs. Long-Term Effects of Adipocyte Toll-like Receptor 4 Activation on Insulin Resistance in Male Mice. Endocrinology. PMID 28323977 DOI: 10.1210/en.2017-00024  0.76
2017 Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Scherer PE. An adipo-biliary-uridine axis that regulates energy homeostasis. Science (New York, N.Y.). 355. PMID 28302796 DOI: 10.1126/science.aaf5375  0.52
2017 Holland WL, Xia JY, Johnson JA, Sun K, Pearson MJ, Sharma AX, Quittner-Strom E, Tippetts TS, Gordillo R, Scherer PE. Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis. Molecular Metabolism. 6: 267-275. PMID 28271033 DOI: 10.1016/j.molmet.2017.01.002  0.76
2017 Park J, Kim M, Sun K, An YA, Gu X, Scherer PE. VEGF-A Expressing Adipose Tissue Shows Rapid Beiging, Enhanced Survival After Transplantation and Confers IL4-Independent Metabolic Improvements. Diabetes. PMID 28254844 DOI: 10.2337/db16-1081  0.76
2017 Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, ... ... Scherer PE, et al. microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism. Nature Communications. 8: 14395. PMID 28205547 DOI: 10.1038/ncomms14395  0.44
2017 Crewe C, An YA, Scherer PE. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. The Journal of Clinical Investigation. 127: 74-82. PMID 28045400 DOI: 10.1172/JCI88883  0.36
2016 Dufurrena Q, Amjad FM, Scherer PE, Weiss LM, Nagajyothi J, Roth J, Tanowitz HB, Kuliawat R. Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies. Parasitology Research. PMID 28013375 DOI: 10.1007/s00436-016-5350-5  0.32
2016 Rutkowski JM, Pastor J, Sun K, Park SK, Bobulescu IA, Chen CT, Moe OW, Scherer PE. Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression. Kidney International. PMID 27914707 DOI: 10.1016/j.kint.2016.09.016  0.76
2016 Fujikawa T, Castorena CM, Pearson M, Kusminski CM, Ahmed N, Battiprolu PK, Kim KW, Lee S, Hill JA, Scherer PE, Holland WL, Elmquist JK. SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise. Elife. 5. PMID 27874828 DOI: 10.7554/eLife.18206  0.32
2016 Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. Journal of Molecular Medicine (Berlin, Germany). PMID 27738746 DOI: 10.1007/s00109-016-1480-6  0.48
2016 Sun K, Park J, Kim M, Scherer PE. Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression, is a predictive biomarker for the response to PPARγ agonist treatment. Diabetologia. PMID 27717959 DOI: 10.1007/s00125-016-4130-1  0.76
2016 Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, Yu KJ, Wang RT, Guo H, Yan J, Chang Y, Chen H, Scherer PE, Liu T, Williams KW. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons. Molecular Metabolism. 5: 882-91. PMID 27689001 DOI: 10.1016/j.molmet.2016.08.007  0.48
2016 Gehrand AL, Hoeynck B, Jablonski M, Leonovicz C, Ye R, Scherer PE, Raff H. Sex differences in adult rat insulin and glucose responses to arginine: programming effects of neonatal separation, hypoxia, and hypothermia. Physiological Reports. 4. PMID 27664190 DOI: 10.14814/phy2.12972  0.32
2016 Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, ... ... Scherer PE, et al. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metabolism. 24: 420-433. PMID 27626200 DOI: 10.1016/j.cmet.2016.08.005  0.48
2016 Turer AT, Scherer PE. Adiponectin: Just Along for the Ride? Circulation Research. 119: 407-8. PMID 27458194 DOI: 10.1161/CIRCRESAHA.116.309226  0.48
2016 Peri-Okonny PA, Ayers C, Maalouf N, Das SR, de Lemos JA, Berry JD, Turer AT, Neeland IJ, Scherer PE, Vongpatanasin W. Adiponectin predicts incident hypertension independent of body fat distribution: observations from the Dallas Heart Study. Diabetes/Metabolism Research and Reviews. PMID 27455039 DOI: 10.1002/dmrr.2840  0.48
2016 Ye R, Wang M, Wang QA, Spurgin SB, Wang ZV, Sun K, Scherer PE. Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges. Molecular Metabolism. 5: 437-48. PMID 27408770 DOI: 10.1016/j.molmet.2016.05.001  0.76
2016 Asterholm IW, Kim-Muller JY, Rutkowski JM, Crewe C, Tao C, Scherer PE. Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnla Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility. The American Journal of Pathology. PMID 27397737 DOI: 10.1016/j.ajpath.2016.04.017  0.36
2016 Haas ME, Levenson AE, Sun X, Liao WH, Rutkowski JM, de Ferranti SD, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 134: 61-72. PMID 27358438 DOI: 10.1161/CIRCULATIONAHA.115.020912  0.48
2016 Kusminski CM, Bickel PE, Scherer PE. Targeting adipose tissue in the treatment of obesity-associated diabetes. Nature Reviews. Drug Discovery. PMID 27256476 DOI: 10.1038/nrd.2016.75  0.32
2016 Stern JH, Rutkowski JM, Scherer PE. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metabolism. 23: 770-84. PMID 27166942 DOI: 10.1016/j.cmet.2016.04.011  0.36
2016 Wang ZV, Scherer PE. Adiponectin, the past two decades. Journal of Molecular Cell Biology. PMID 26993047 DOI: 10.1093/jmcb/mjw011  0.52
2016 Iyengar P, Scherer PE. Obesity: Slim without the gym - the magic of chilling out. Nature Reviews. Endocrinology. 12: 252-4. PMID 26915527 DOI: 10.1038/nrendo.2016.20  1
2016 Kusminski CM, Chen S, Ye R, Sun K, Wang QA, Spurgin SB, Sanders PE, Brozinick JT, Li WH, Unger RH, Scherer PE. MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival and Intra-Insular Crosstalk. Diabetes. PMID 26895793 DOI: 10.2337/db15-1323  0.48
2016 Zhu Y, Crewe C, Scherer PE. Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier. Science Translational Medicine. 8: 323ps4. PMID 26819194 DOI: 10.1126/scitranslmed.aad6793  0.36
2016 Davidson JA, Holland WL, Roth MG, Wang MY, Lee Y, Yu X, McCorkle SK, Scherer PE, Unger RH. Glucagon therapeutics, dawn of a new era for diabetes care. Diabetes/Metabolism Research and Reviews. PMID 26729301 DOI: 10.1002/dmrr.2773  0.44
2016 Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. 65: 610-8. PMID 26718495 DOI: 10.2337/db15-1478  0.48
2015 Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE. Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase. Molecular Metabolism. 4: 771-778. PMID 26629402 DOI: 10.1016/j.molmet.2015.08.004  0.48
2015 Kusminski CM, Gallardo-Montejano VI, Wang ZV, Hegde V, Bickel PE, Dhurandhar NV, Scherer PE. E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte. Molecular Metabolism. 4: 653-64. PMID 26500839 DOI: 10.1016/j.molmet.2015.07.004  0.52
2015 Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK, Scherer PE. Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nature Cell Biology. 17: 1099-111. PMID 26280538 DOI: 10.1038/ncb3217  0.4
2015 Morley TS, Xia JY, Scherer PE. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nature Communications. 6: 7906. PMID 26243466 DOI: 10.1038/ncomms8906  0.44
2015 Xia JY, Holland WL, Kusminski CM, Sun K, Sharma AX, Pearson MJ, Sifuentes AJ, McDonald JG, Gordillo R, Scherer PE. Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis. Cell Metabolism. 22: 266-278. PMID 26190650 DOI: 10.1016/j.cmet.2015.06.007  0.48
2015 Gunter MJ, Wang T, Cushman M, Xue X, Wassertheil-Smoller S, Strickler HD, Rohan TE, Manson JE, McTiernan A, Kaplan RC, Scherer PE, Chlebowski RT, Snetselaar L, Wang D, Ho GY. Circulating Adipokines and Inflammatory Markers and Postmenopausal Breast Cancer Risk. Journal of the National Cancer Institute. 107. PMID 26185195 DOI: 10.1093/jnci/djv169  0.48
2015 Beg MS, Saleem S, Turer A, Ayers C, de Lemos JA, Khera A, Scherer PE, Lakoski SG. A Prospective Analysis of Plasma Adiponectin and Risk of Incident Cancer: The Dallas Heart Study. Journal of the National Comprehensive Cancer Network : Jnccn. 13: 873-8. PMID 26150581  0.48
2015 Mansuy-Aubert V, Gautron L, Lee S, Bookout AL, Kusminski C, Sun K, Zhang Y, Scherer PE, Mangelsdorf DJ, Elmquist JK. Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure. Elife. 4. PMID 26076474 DOI: 10.7554/eLife.06667  0.48
2015 Combs TP, Snell-Bergeon JK, Maahs DM, Bergman BC, Lamarche M, Iberkleid L, AbdelBaky O, Tisch R, Scherer PE, Marliss EB. Adiponectin-SOGA Dissociation in Type 1 Diabetes. The Journal of Clinical Endocrinology and Metabolism. 100: E1065-73. PMID 26052615 DOI: 10.1210/jc.2015-1275  0.48
2015 Warshauer JT, Lopez X, Gordillo R, Hicks J, Holland WL, Anuwe E, Blankfard MB, Scherer PE, Lingvay I. Effect of pioglitazone on plasma ceramides in adults with metabolic syndrome. Diabetes/Metabolism Research and Reviews. PMID 25959529 DOI: 10.1002/dmrr.2662  0.48
2015 Kusminski CM, Scherer PE. Leptin beyond the lipostat: key component of blood pressure regulation. Circulation Research. 116: 1293-5. PMID 25858061 DOI: 10.1161/CIRCRESAHA.115.305937  0.32
2015 Ye R, Wang M, Wang QA, Scherer PE. Adiponectin-mediated antilipotoxic effects in regenerating pancreatic islets. Endocrinology. 156: 2019-28. PMID 25815422 DOI: 10.1210/en.2015-1066  0.4
2015 Rutkowski JM, Stern JH, Scherer PE. The cell biology of fat expansion. The Journal of Cell Biology. 208: 501-12. PMID 25733711 DOI: 10.1083/jcb.201409063  0.48
2015 Burrill JS, Long EK, Reilly B, Deng Y, Armitage IM, Scherer PE, Bernlohr DA. Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes. Molecular Endocrinology (Baltimore, Md.). 29: 411-20. PMID 25635940 DOI: 10.1210/me.2014-1275  0.48
2015 Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A, Wan Y. Maternal adiponectin controls milk composition to prevent neonatal inflammation. Endocrinology. 156: 1504-13. PMID 25590242 DOI: 10.1210/en.2014-1738  0.48
2015 Stern JH, Scherer PE. Adipose tissue biology in 2014: Advances in our understanding of adipose tissue homeostasis. Nature Reviews. Endocrinology. 11: 71-2. PMID 25511312 DOI: 10.1038/nrendo.2014.219  0.48
2015 Marangoni RG, Korman BD, Wei J, Wood TA, Graham LV, Whitfield ML, Scherer PE, Tourtellotte WG, Varga J. Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1062-73. PMID 25504959 DOI: 10.1002/art.38990  0.48
2015 de Seigneux S, Courbebaisse M, Rutkowski JM, Wilhelm-Bals A, Metzger M, Khodo SN, Hasler U, Chehade H, Dizin E, Daryadel A, Stengel B, Girardin E, Prié D, Wagner CA, ... Scherer PE, et al. Proteinuria Increases Plasma Phosphate by Altering Its Tubular Handling. Journal of the American Society of Nephrology : Jasn. 26: 1608-18. PMID 25349200 DOI: 10.1681/ASN.2014010104  0.48
2014 Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN. MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. Embo Molecular Medicine. 6: 1610-21. PMID 25422356 DOI: 10.15252/emmm.201404218  0.48
2014 Ryu TY, Park J, Scherer PE. Hyperglycemia as a risk factor for cancer progression. Diabetes & Metabolism Journal. 38: 330-6. PMID 25349819 DOI: 10.4093/dmj.2014.38.5.330  0.76
2014 Ye R, Holland WL, Gordillo R, Wang M, Wang QA, Shao M, Morley TS, Gupta RK, Stahl A, Scherer PE. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. Elife. 3. PMID 25339419 DOI: 10.7554/eLife.03851  0.48
2014 Nagajyothi F, Weiss LM, Zhao D, Koba W, Jelicks LA, Cui MH, Factor SM, Scherer PE, Tanowitz HB. High fat diet modulates Trypanosoma cruzi infection associated myocarditis. Plos Neglected Tropical Diseases. 8: e3118. PMID 25275627 DOI: 10.1371/journal.pntd.0003118  0.48
2014 Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ. ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue. Molecular Metabolism. 3: 642-51. PMID 25161887 DOI: 10.1016/j.molmet.2014.05.007  0.48
2014 Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH. Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 13217-22. PMID 25157166 DOI: 10.1073/pnas.1409638111  0.48
2014 Burke S, Nagajyothi F, Thi MM, Hanani M, Scherer PE, Tanowitz HB, Spray DC. Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: implications for Chagas disease. Microbes and Infection / Institut Pasteur. 16: 893-901. PMID 25150689 DOI: 10.1016/j.micinf.2014.08.006  0.48
2014 Tanaka K, Wilson RM, Essick EE, Duffen JL, Scherer PE, Ouchi N, Sam F. Effects of adiponectin on calcium-handling proteins in heart failure with preserved ejection fraction. Circulation. Heart Failure. 7: 976-85. PMID 25149095 DOI: 10.1161/CIRCHEARTFAILURE.114.001279  0.48
2014 Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, ... ... Scherer PE, et al. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism. 20: 471-82. PMID 25017942 DOI: 10.1016/j.cmet.2014.06.002  0.48
2014 Wen JJ, Nagajyothi F, Machado FS, Weiss LM, Scherer PE, Tanowitz HB, Garg NJ. Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection. Parasitology Research. 113: 3159-65. PMID 24948102 DOI: 10.1007/s00436-014-3977-7  0.48
2014 Sun K, Kusminski CM, Luby-Phelps K, Spurgin SB, An YA, Wang QA, Holland WL, Scherer PE. Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure. Molecular Metabolism. 3: 474-83. PMID 24944907 DOI: 10.1016/j.molmet.2014.03.010  0.76
2014 Ye R, Scherer PE. Fabp4, a new player in the adipo-pancreatic axis. Molecular Metabolism. 3: 347-8. PMID 24944893 DOI: 10.1016/j.molmet.2014.03.009  0.48
2014 Park J, Morley TS, Kim M, Clegg DJ, Scherer PE. Obesity and cancer--mechanisms underlying tumour progression and recurrence. Nature Reviews. Endocrinology. 10: 455-65. PMID 24935119 DOI: 10.1038/nrendo.2014.94  0.48
2014 Wernstedt Asterholm I, Tao C, Morley TS, Wang QA, Delgado-Lopez F, Wang ZV, Scherer PE. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metabolism. 20: 103-18. PMID 24930973 DOI: 10.1016/j.cmet.2014.05.005  0.48
2014 Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nature Neuroscience. 17: 911-3. PMID 24908101 DOI: 10.1038/nn.3737  0.48
2014 Kusminski CM, Park J, Scherer PE. MitoNEET-mediated effects on browning of white adipose tissue. Nature Communications. 5: 3962. PMID 24865177 DOI: 10.1038/ncomms4962  0.76
2014 Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nature Communications. 5: 3878. PMID 24815961 DOI: 10.1038/ncomms4878  0.48
2014 Mundy DI, Lopez AM, Posey KS, Chuang JC, Ramirez CM, Scherer PE, Turley SD. Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1. Biochimica Et Biophysica Acta. 1841: 995-1002. PMID 24747682 DOI: 10.1016/j.bbalip.2014.04.002  0.48
2014 Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metabolism. 19: 967-80. PMID 24746805 DOI: 10.1016/j.cmet.2014.03.018  0.48
2014 Liu C, Bookout AL, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, Scherer PE, Mangelsdorf DJ, Gautron L, Elmquist JK. PPARγ in vagal neurons regulates high-fat diet induced thermogenesis. Cell Metabolism. 19: 722-30. PMID 24703703 DOI: 10.1016/j.cmet.2014.01.021  0.48
2014 Sun K, Park J, Gupta OT, Holland WL, Auerbach P, Zhang N, Goncalves Marangoni R, Nicoloro SM, Czech MP, Varga J, Ploug T, An Z, Scherer PE. Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nature Communications. 5: 3485. PMID 24647224 DOI: 10.1038/ncomms4485  0.76
2014 Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, ... ... Scherer PE, et al. Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway Cell. 156: 1179-1192. PMID 24630721 DOI: 10.1016/j.cell.2014.01.014  0.48
2014 Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 57: 1209-18. PMID 24623101 DOI: 10.1007/s00125-014-3210-3  0.48
2014 Rutkowski JM, Halberg N, Wang QA, Holland WL, Xia JY, Scherer PE. Differential transendothelial transport of adiponectin complexes. Cardiovascular Diabetology. 13: 47. PMID 24552349 DOI: 10.1186/1475-2840-13-47  0.36
2014 Wang QA, Scherer PE, Gupta RK. Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. Journal of Lipid Research. 55: 605-24. PMID 24532650 DOI: 10.1194/jlr.R046441  0.4
2014 Rutkowski JM, Scherer PE. Isolation and quantitation of adiponectin higher order complexes. Methods in Enzymology. 537: 243-59. PMID 24480350 DOI: 10.1016/B978-0-12-411619-1.00013-6  0.36
2014 Bueno AC, Sun K, Martins CS, Elias Junior J, Miranda W, Tao C, Foss-Freitas MC, Barbieri MA, Bettiol H, de Castro M, Scherer PE, Antonini SR. A novel ADIPOQ mutation (p.M40K) impairs assembly of high-molecular-weight adiponectin and is associated with early-onset obesity and metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism. 99: E683-93. PMID 24432991 DOI: 10.1210/jc.2013-3009  0.48
2014 Zhu H, Guariglia S, Li W, Brancho D, Wang ZV, Scherer PE, Chow CW. Role of extracellular signal-regulated kinase 5 in adipocyte signaling. The Journal of Biological Chemistry. 289: 6311-22. PMID 24425864 DOI: 10.1074/jbc.M113.506584  0.52
2014 Mitsnefes M, Scherer PE, Friedman LA, Gordillo R, Furth S, Warady BA. Ceramides and cardiac function in children with chronic kidney disease. Pediatric Nephrology (Berlin, Germany). 29: 415-22. PMID 24389650 DOI: 10.1007/s00467-013-2642-1  0.48
2014 Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT. Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket. The Journal of Biological Chemistry. 289: 4432-43. PMID 24356970 DOI: 10.1074/jbc.M113.533885  0.48
2014 Lackey DE, Burk DH, Ali MR, Mostaedi R, Smith WH, Park J, Scherer PE, Seay SA, McCoin CS, Bonaldo P, Adams SH. Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. American Journal of Physiology. Endocrinology and Metabolism. 306: E233-46. PMID 24302007 DOI: 10.1152/ajpendo.00476.2013  0.48
2014 Xia JY, Morley TS, Scherer PE. The adipokine/ceramide axis: key aspects of insulin sensitization. Biochimie. 96: 130-9. PMID 23969158 DOI: 10.1016/j.biochi.2013.08.013  0.48
2013 Sherwani SI, Aldana C, Usmani S, Adin C, Kotha S, Khan M, Eubank T, Scherer PE, Parinandi N, Magalang UJ. Intermittent hypoxia exacerbates pancreatic β-cell dysfunction in a mouse model of diabetes mellitus Sleep. 36: 1849-1858. PMID 24293759 DOI: 10.5665/sleep.3214  0.48
2013 Unger RH, Scherer PE, Holland WL. Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine. Molecular Biology of the Cell. 24: 3011-5. PMID 24072813 DOI: 10.1091/mbc.E12-10-0774  0.44
2013 Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity? Molecular Metabolism. 2: 133-41. PMID 24049728 DOI: 10.1016/j.molmet.2013.04.001  0.48
2013 Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nature Medicine. 19: 1338-44. PMID 23995282 DOI: 10.1038/nm.3324  0.4
2013 Sun K, Tordjman J, Clément K, Scherer PE. Fibrosis and adipose tissue dysfunction. Cell Metabolism. 18: 470-7. PMID 23954640 DOI: 10.1016/j.cmet.2013.06.016  0.76
2013 He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, et al. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 154: 1085-99. PMID 23954414 DOI: 10.1016/j.cell.2013.07.035  0.48
2013 Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metabolism. 17: 790-7. PMID 23663742 DOI: 10.1016/j.cmet.2013.03.019  0.48
2013 Park J, Morley TS, Scherer PE. Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours. Embo Molecular Medicine. 5: 935-48. PMID 23629957 DOI: 10.1002/emmm.201202006  0.48
2013 Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer PE. Plasma ceramides are elevated in female children and adolescents with type 2 diabetes. Journal of Pediatric Endocrinology & Metabolism : Jpem. 26: 995-8. PMID 23612696 DOI: 10.1515/jpem-2012-0407  0.36
2013 Wildman RP, Wang D, Fernandez I, Mancuso P, Santoro N, Scherer PE, Sowers MR. Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. Obesity (Silver Spring, Md.). 21: 629-36. PMID 23592672 DOI: 10.1002/oby.20256  0.48
2013 Park J, Scherer PE. Endotrophin in the tumor stroma: a new therapeutic target for breast cancer? Expert Review of Anticancer Therapy. 13: 111-3. PMID 23406549 DOI: 10.1586/era.12.164  0.76
2013 Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC, Moe OW, Susztak K, Scherer PE. Adiponectin promotes functional recovery after podocyte ablation. Journal of the American Society of Nephrology : Jasn. 24: 268-82. PMID 23334396 DOI: 10.1681/ASN.2012040414  0.52
2013 Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. American Journal of Respiratory and Critical Care Medicine. 188: 240-8. PMID 23328524 DOI: 10.1164/rccm.201209-1688OC  0.48
2013 Nagajyothi F, Kuliawat R, Kusminski CM, Machado FS, Desruisseaux MS, Zhao D, Schwartz GJ, Huang H, Albanese C, Lisanti MP, Singh R, Li F, Weiss LM, Factor SM, Pessin JE, ... Scherer PE, et al. Alterations in glucose homeostasis in a murine model of Chagas disease. The American Journal of Pathology. 182: 886-94. PMID 23321322 DOI: 10.1016/j.ajpath.2012.11.027  0.48
2013 Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, et al. Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. The Journal of Biological Chemistry. 288: 3477-88. PMID 23258544 DOI: 10.1074/jbc.M112.419150  0.48
2013 Deng Y, Wang ZV, Tao C, Gao N, Holland WL, Ferdous A, Repa JJ, Liang G, Ye J, Lehrman MA, Hill JA, Horton JD, Scherer PE. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. The Journal of Clinical Investigation. 123: 455-68. PMID 23257357 DOI: 10.1172/JCI62819  0.48
2013 Sun K, Halberg N, Khan M, Magalang UJ, Scherer PE. Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction. Molecular and Cellular Biology. 33: 904-17. PMID 23249949 DOI: 10.1128/MCB.00951-12  0.76
2012 Park J, Scherer PE. Endotrophin - a novel factor linking obesity with aggressive tumor growth. Oncotarget. 3: 1487-8. PMID 23455368 DOI: 10.18632/oncotarget.796  0.76
2012 Park J, Scherer PE. Endotrophin - a Novel Factor Linking Obesity with Aggressive Tumor Growth. Oncotarget. PMID 23328277 DOI: 10.18632/oncotarget.796  0.76
2012 Turer AT, Hill JA, Elmquist JK, Scherer PE. Adipose tissue biology and cardiomyopathy: translational implications. Circulation Research. 111: 1565-77. PMID 23223931 DOI: 10.1161/CIRCRESAHA.111.262493  0.48
2012 Asterholm IW, Scherer PE. Metabolic jet lag when the fat clock is out of sync. Nature Medicine. 18: 1738-40. PMID 23223058 DOI: 10.1038/nm.3010  0.32
2012 Park J, Sarode VR, Euhus D, Kittler R, Scherer PE. Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 21058-63. PMID 23213231 DOI: 10.1073/pnas.1214400109  0.76
2012 Park J, Scherer PE. Adipocyte-derived endotrophin promotes malignant tumor progression. The Journal of Clinical Investigation. 122: 4243-56. PMID 23041627 DOI: 10.1172/JCI63930  0.76
2012 Elmquist JK, Scherer PE. The cover. Neuroendocrine and endocrine pathways of obesity. Jama. 308: 1070-1. PMID 22990243 DOI: 10.1001/jama.2012.3209  0.48
2012 Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nature Medicine. 18: 1539-49. PMID 22961109 DOI: 10.1038/nm.2899  0.76
2012 Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, Zhou L, Chen H, Xiang G, Walter CA, Austad SN, Musi N, DeFronzo RA, Asmis R, Scherer PE, et al. Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 61: 2776-86. PMID 22807031 DOI: 10.2337/db12-0169  0.48
2010 Zhu H, Suk HY, Yu RY, Brancho D, Olabisi O, Yang TT, Yang X, Zhang J, Moussaif M, Durand JL, Jelicks LA, Kim JY, Scherer PE, Frank PG, Lisanti MP, et al. Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. Molecular and Cellular Biology. 30: 4379-90. PMID 20647544 DOI: 10.1128/MCB.01193-09  0.48
2010 Landskroner-Eiger S, Park J, Israel D, Pollard JW, Scherer PE. Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes. Developmental Biology. 344: 968-78. PMID 20599899 DOI: 10.1016/j.ydbio.2010.06.019  0.48
2009 Khan T, Hamilton MP, Mundy DI, Chua SC, Scherer PE. Impact of simvastatin on adipose tissue: pleiotropic effects in vivo. Endocrinology. 150: 5262-72. PMID 19819942 DOI: 10.1210/en.2009-0603  0.48
2009 Halberg N, Schraw TD, Wang ZV, Kim JY, Yi J, Hamilton MP, Luby-Phelps K, Scherer PE. Systemic fate of the adipocyte-derived factor adiponectin. Diabetes. 58: 1961-70. PMID 19581422 DOI: 10.2337/db08-1750  0.48
2009 Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Molecular and Cellular Biology. 29: 4467-83. PMID 19546236 DOI: 10.1128/MCB.00192-09  0.52
2009 Landskroner-Eiger S, Qian B, Muise ES, Nawrocki AR, Berger JP, Fine EJ, Koba W, Deng Y, Pollard JW, Scherer PE. Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3265-76. PMID 19447867 DOI: 10.1158/1078-0432.CCR-08-2649  0.48
2009 Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Molecular and Cellular Biology. 29: 1575-91. PMID 19114551 DOI: 10.1128/MCB.01300-08  1
2007 Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, Jelicks LA, Mehler MF, Hui DY, Deshaies Y, Shulman GI, ... ... Scherer PE, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. The Journal of Clinical Investigation. 117: 2621-37. PMID 17717599 DOI: 10.1172/JCI31021  0.48
2007 Basu R, Pajvani UB, Rizza RA, Scherer PE. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes. 56: 2174-7. PMID 17513700 DOI: 10.2337/db07-0185  1
2007 Lin HV, Kim JY, Pocai A, Rossetti L, Shapiro L, Scherer PE, Accili D. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes. 56: 1969-76. PMID 17475934 DOI: 10.2337/db07-0127  0.96
2007 Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, Scherer PE. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Molecular and Cellular Biology. 27: 3716-31. PMID 17353260 DOI: 10.1128/MCB.00931-06  0.96
2006 Corvera S, Burkart A, Kim JY, Christianson J, Wang Z, Scherer PE. Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada. Genes & Development. 20: 2193-201. PMID 16912272 DOI: 10.1101/gad.1447506  0.96
2006 Yang TT, Suk HY, Yang X, Olabisi O, Yu RY, Durand J, Jelicks LA, Kim JY, Scherer PE, Wang Y, Feng Y, Rossetti L, Graef IA, Crabtree GR, Chow CW. Role of transcription factor NFAT in glucose and insulin homeostasis. Molecular and Cellular Biology. 26: 7372-87. PMID 16908540 DOI: 10.1128/MCB.00580-06  0.48
2006 Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 281: 2654-60. PMID 16326714 DOI: 10.1074/jbc.M505311200  1
2006 Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. American Journal of Physiology. Endocrinology and Metabolism. 290: E814-23. PMID 16303844 DOI: 10.1152/ajpendo.00465.2005  0.48
2005 Trujillo ME, Pajvani UB, Scherer PE. Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation. Cell Cycle (Georgetown, Tex.). 4: 1141-5. PMID 16096375 DOI: 10.4161/cc.4.9.2030  1
2005 Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel ED. Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. The Journal of Biological Chemistry. 280: 31679-85. PMID 15983036 DOI: 10.1074/jbc.M504008200  0.88
2005 Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nature Medicine. 11: 797-803. PMID 15965483 DOI: 10.1038/nm1262  0.48
2005 Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circulation Research. 96: 939-49. PMID 15890981 DOI: 10.1161/01.RES.0000163635.62927.34  0.88
2005 Combs TP, Nagajyothi, Mukherjee S, de Almeida CJ, Jelicks LA, Schubert W, Lin Y, Jayabalan DS, Zhao D, Braunstein VL, Landskroner-Eiger S, Cordero A, Factor SM, Weiss LM, Lisanti MP, ... ... Scherer PE, et al. The adipocyte as an important target cell for Trypanosoma cruzi infection. The Journal of Biological Chemistry. 280: 24085-94. PMID 15843370 DOI: 10.1074/jbc.M412802200  0.48
2005 Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, ... ... Scherer PE, et al. Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. The Journal of Clinical Investigation. 115: 1163-76. PMID 15841211 DOI: 10.1172/JCI23424  0.48
2005 Bouskila M, Pajvani UB, Scherer PE. Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity? International Journal of Obesity (2005). 29: S17-23. PMID 15711577 DOI: 10.1038/sj.ijo.0802908  1
2005 Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, ... Scherer PE, et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. The Journal of Biological Chemistry. 280: 4617-26. PMID 15536073 DOI: 10.1074/jbc.M411863200  1
2004 Kim JY, Scherer PE. Adiponectin, an adipocyte-derived hepatic insulin sensitizer regulation during development. Pediatric Endocrinology Reviews : Per. 1: 428-31. PMID 16444169  0.96
2004 Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D. Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes. Diabetologia. 47: 2215-25. PMID 15662559 DOI: 10.1007/s00125-004-1581-6  1
2004 Florant GL, Porst H, Peiffer A, Hudachek SF, Pittman C, Summers SA, Rajala MW, Scherer PE. Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris). Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. 174: 633-9. PMID 15517283 DOI: 10.1007/s00360-004-0454-0  0.48
2004 Mancia F, Patel SD, Rajala MW, Scherer PE, Nemes A, Schieren I, Hendrickson WA, Shapiro L. Optimization of protein production in mammalian cells with a coexpressed fluorescent marker Structure. 12: 1355-1360. PMID 15296729 DOI: 10.1016/j.str.2004.06.012  0.48
2004 Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, Rossetti L. Role of resistin in diet-induced hepatic insulin resistance. The Journal of Clinical Investigation. 114: 232-9. PMID 15254590 DOI: 10.1172/JCI21270  0.88
2004 Berg AH, Lin Y, Lisanti MP, Scherer PE. Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity. American Journal of Physiology. Endocrinology and Metabolism. 287: E1178-88. PMID 15251865 DOI: 10.1152/ajpendo.00002.2004  0.48
2004 Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB, Sinha MK, Gingerich RL, Scherer PE, Ahima RS. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes. 53: 1671-9. PMID 15220189  1
2004 Tonelli J, Li W, Kishore P, Pajvani UB, Kwon E, Weaver C, Scherer PE, Hawkins M. Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes. Diabetes. 53: 1621-9. PMID 15161771  1
2004 Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L. Disulfide-dependent multimeric assembly of resistin family hormones. Science (New York, N.Y.). 304: 1154-8. PMID 15155948 DOI: 10.1126/science.1093466  0.48
2004 Cohen AW, Razani B, Schubert W, Williams TM, Wang XB, Iyengar P, Brasaemle DL, Scherer PE, Lisanti MP. Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes. 53: 1261-70. PMID 15111495 DOI: 10.2337/diabetes.53.5.1261  0.48
2004 Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS. Adiponectin acts in the brain to decrease body weight. Nature Medicine. 10: 524-9. PMID 15077108 DOI: 10.1038/nm1029  0.48
2004 Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, Lisanti MP. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. The Journal of Biological Chemistry. 279: 24745-56. PMID 15044451 DOI: 10.1074/jbc.M402064200  0.48
2004 Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA. Regulation of fasted blood glucose by resistin. Science (New York, N.Y.). 303: 1195-8. PMID 14976316 DOI: 10.1126/science.1092341  0.48
2004 Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. The Journal of Biological Chemistry. 279: 12152-62. PMID 14699128 DOI: 10.1074/jbc.M311113200  0.48
2004 Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, ... ... Scherer PE, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology. 145: 367-83. PMID 14576179 DOI: 10.1210/en.2003-1068  0.48
2003 Iyengar P, Scherer PE. Adiponectin/Acrp30, an adipocyte-specific secretory factor: physiological relevance during development. Pediatric Diabetes. 4: 32-7. PMID 14655522 DOI: 10.1034/j.1399-5448.2003.00029.x  1
2003 Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP, Pestell RG, Scherer PE. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 22: 6408-23. PMID 14508521 DOI: 10.1038/sj.onc.1206737  0.48
2003 Rajala MW, Scherer PE. Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology. 144: 3765-73. PMID 12933646 DOI: 10.1210/en.2003-0580  0.88
2003 Pajvani UB, Scherer PE. Adiponectin: systemic contributor to insulin sensitivity. Current Diabetes Reports. 3: 207-13. PMID 12762967  1
2003 Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 52: 268-76. PMID 12540596 DOI: 10.2337/diabetes.52.2.268  0.48
2003 Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. The Journal of Clinical Investigation. 111: 225-30. PMID 12531878 DOI: 10.1172/JCI16521  0.88
2003 Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. The Journal of Biological Chemistry. 278: 9073-85. PMID 12496257 DOI: 10.1074/jbc.M207198200  1
2002 Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, ... ... Scherer PE, et al. Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization. Endocrinology. 143: 998-1007. PMID 28201619 DOI: 10.1210/endo.143.3.8662  0.88
2002 Rajala MW, Lin Y, Ranalletta M, Yang XM, Qian H, Gingerich R, Barzilai N, Scherer PE. Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue. Molecular Endocrinology (Baltimore, Md.). 16: 1920-30. PMID 12145345 DOI: 10.1210/me.2002-0048  0.48
2002 Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 51: 2306-12. PMID 12086965  0.88
2002 Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, ... ... Scherer PE, et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology. 143: 998-1007. PMID 11861525 DOI: 10.1210/endo.143.3.8662  0.48
2002 Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends in Endocrinology and Metabolism: Tem. 13: 84-9. PMID 11854024  0.88
2001 Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. The Journal of Clinical Investigation. 108: 1875-81. PMID 11748271 DOI: 10.1172/JCI14120  0.88
2001 Lin Y, Rajala MW, Berger JP, Moller DE, Barzilai N, Scherer PE. Hyperglycemia-induced production of acute phase reactants in adipose tissue. The Journal of Biological Chemistry. 276: 42077-83. PMID 11546817 DOI: 10.1074/jbc.M107101200  0.88
2001 Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine. 7: 947-53. PMID 11479628 DOI: 10.1038/90992  0.48
2000 Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, Wilson MT, Campos-Gonzalez R, Bouzahzah B, Pestell RG, Scherer PE, Lisanti MP. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Molecular Endocrinology (Baltimore, Md.). 14: 1750-75. PMID 11075810 DOI: 10.1210/mend.14.11.0553  1
2000 Engelman JA, Berg AH, Lewis RY, Lisanti MP, Scherer PE. Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Molecular Endocrinology (Baltimore, Md.). 14: 1557-69. PMID 11043572 DOI: 10.1210/mend.14.10.0542  0.48
2000 Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. The Journal of Biological Chemistry. 275: 24255-63. PMID 10823826 DOI: 10.1074/jbc.M002137200  0.48
1999 Engelman JA, Berg AH, Lewis RY, Lin A, Lisanti MP, Scherer PE. Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis. The Journal of Biological Chemistry. 274: 35630-8. PMID 10585441 DOI: 10.1074/jbc.274.50.35630  0.48
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