Ishwar Radhakrishnan - Publications

Interdepartmental Biological Sciences Program Northwestern University, Evanston, IL 
General Biophysics

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Daffern N, Chen Z, Zhang Y, Pick L, Radhakrishnan I. Solution NMR Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveals a Dynamic Helix in the Ligand-Binding Pocket. Biochemistry. PMID 29547262 DOI: 10.1021/acs.biochem.8b00069  0.6
2015 Clark MD, Zhang Y, Radhakrishnan I. Solution NMR Studies of an Alternative Mode of Sin3 Engagement by the Sds3 Subunit in the Histone Deacetylase-Associated Sin3L/Rpd3L Corepressor Complex. Journal of Molecular Biology. PMID 26522936 DOI: 10.1016/j.jmb.2015.10.018  0.76
2015 Clark M, Kumar GS, Marcum R, Luo Q, Zhang Y, Radhakrishnan I. Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and its Implications in cAMP Signaling. Biochemistry. PMID 26274502 DOI: 10.1021/acs.biochem.5b00332  0.76
2015 Clark MD, Marcum R, Graveline R, Chan CW, Xie T, Chen Z, Ding Y, Zhang Y, Mondragón A, David G, Radhakrishnan I. Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124119 DOI: 10.1073/pnas.1504021112  0.76
2015 Xie T, Zmyslowski AM, Zhang Y, Radhakrishnan I. Structural Basis for Multi-specificity of MRG Domains. Structure (London, England : 1993). 23: 1049-57. PMID 25960410 DOI: 10.1016/j.str.2015.03.020  0.76
2015 Kim JY, Banerjee T, Vinckevicius A, Luo Q, Parker JB, Baker MR, Radhakrishnan I, Wei JJ, Barish GD, Chakravarti D. A Role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone h3 during androgen signaling and in prostate cancer [Molecular Cell, 54, (2014), 613-625] Molecular Cell. 58: 557. DOI: 10.1016/j.molcel.2015.04.030  0.76
2014 Kim JY, Banerjee T, Vinckevicius A, Luo Q, Parker JB, Baker MR, Radhakrishnan I, Wei JJ, Barish GD, Chakravarti D. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Molecular Cell. 54: 613-25. PMID 24793694 DOI: 10.1016/j.molcel.2014.03.043  0.76
2012 Luo Q, Viste K, Urday-Zaa JC, Senthil Kumar G, Tsai WW, Talai A, Mayo KE, Montminy M, Radhakrishnan I. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. Proceedings of the National Academy of Sciences of the United States of America. 109: 20865-70. PMID 23213254 DOI: 10.1073/pnas.1219028109  0.76
2012 Kumar GS, Chang W, Xie T, Patel A, Zhang Y, Wang GG, David G, Radhakrishnan I. Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. Journal of Molecular Biology. 422: 519-31. PMID 22728643 DOI: 10.1016/j.jmb.2012.06.013  0.76
2012 Xie T, Graveline R, Kumar GS, Zhang Y, Krishnan A, David G, Radhakrishnan I. Structural basis for molecular interactions involving MRG domains: implications in chromatin biology. Structure (London, England : 1993). 20: 151-60. PMID 22244764 DOI: 10.1016/j.str.2011.10.019  0.76
2011 Xie T, He Y, Korkeamaki H, Zhang Y, Imhoff R, Lohi O, Radhakrishnan I. Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding. The Journal of Biological Chemistry. 286: 27814-24. PMID 21676866 DOI: 10.1074/jbc.M111.252494  0.76
2011 Filippova EV, Shuvalova L, Minasov G, Kiryukhina O, Zhang Y, Clancy S, Radhakrishnan I, Joachimiak A, Anderson WF. Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production Proteins: Structure, Function and Bioinformatics. 79: 2566-2577. PMID 21633970 DOI: 10.1002/prot.23062  0.76
2011 Kumar GS, Xie T, Zhang Y, Radhakrishnan I. Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex. Journal of Molecular Biology. 408: 987-1000. PMID 21440557 DOI: 10.1016/j.jmb.2011.03.043  0.76
2009 He Y, Imhoff R, Sahu A, Radhakrishnan I. Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition. Nucleic Acids Research. 37: 2142-52. PMID 19223330 DOI: 10.1093/nar/gkp051  1
2008 Neuhaus F, Widom J, MacDonald R, Jardetzky T, Radhakrishnan I. Program review: Challenges and opportunities for training the next generation of biophysicists: Perspectives of the directors of the Molecular Biophysics Training Program at Northwestern University Biopolymers. 89: 253-255. PMID 18293401 DOI: 10.1002/bip.20929  0.76
2008 Sahu SC, Swanson KA, Kang RS, Huang K, Brubaker K, Ratcliff K, Radhakrishnan I. Conserved themes in target recognition by the PAH1 and PAH2 domains of the Sin3 transcriptional corepressor. Journal of Molecular Biology. 375: 1444-56. PMID 18089292 DOI: 10.1016/j.jmb.2007.11.079  0.76
2008 He Y, Radhakrishnan I. Solution NMR studies of apo-mSin3A and -mSin3B reveal that the PAH1 and PAH2 domains are structurally independent. Protein Science : a Publication of the Protein Society. 17: 171-5. PMID 18042683 DOI: 10.1110/ps.073097308  1
2007 He Y, Hicke L, Radhakrishnan I. Structural basis for ubiquitin recognition by SH3 domains. Journal of Molecular Biology. 373: 190-6. PMID 17765920 DOI: 10.1016/j.jmb.2007.07.074  1
2007 Lerch TF, Xu M, Jardetzky TS, Mayo KE, Radhakrishnan I, Kazer R, Shea LD, Woodruff TK. The structures that underlie normal reproductive function Molecular and Cellular Endocrinology. 267: 1-5. PMID 17140726 DOI: 10.1016/j.mce.2006.10.018  0.76
2006 Zhang Y, Zhang Z, Demeler B, Radhakrishnan I. Coupled unfolding and dimerization by the PAH2 domain of the mammalian Sin3A corepressor. Journal of Molecular Biology. 360: 7-14. PMID 16813833 DOI: 10.1016/j.jmb.2006.04.069  0.76
2006 Swanson KA, Hicke L, Radhakrishnan I. Structural basis for monoubiquitin recognition by the Ede1 UBA domain. Journal of Molecular Biology. 358: 713-24. PMID 16563434 DOI: 10.1016/j.jmb.2006.02.059  0.76
2006 Huang K, Wu CW, Sanborn TJ, Patch JA, Kirshenbaum K, Zuckermann RN, Barron AE, Radhakrishnan I. A threaded loop conformation adopted by a family of peptoid nonamers. Journal of the American Chemical Society. 128: 1733-8. PMID 16448149 DOI: 10.1021/ja0574318  0.76
2006 Little TH, Zhang Y, Matulis CK, Weck J, Zhang Z, Ramachandran A, Mayo KE, Radhakrishnan I. Sequence-specific deoxyribonucleic acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability. Molecular Endocrinology (Baltimore, Md.). 20: 831-43. PMID 16339274 DOI: 10.1210/me.2005-0384  0.76
2005 French M, Swanson K, Shih SC, Radhakrishnan I, Hicke L. Identification and characterization of modular domains that bind ubiquitin. Methods in Enzymology. 399: 135-57. PMID 16338353 DOI: 10.1016/S0076-6879(05)99009-5  0.48
2004 Pham JW, Radhakrishnan I, Sontheimer EJ. Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Research. 32: 3446-55. PMID 15247335 DOI: 10.1093/nar/gkh658  0.76
2004 Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nature Structural & Molecular Biology. 11: 738-46. PMID 15235594 DOI: 10.1038/nsmb798  0.76
2004 Salerno WJ, Seaver SM, Armstrong BR, Radhakrishnan I. MONSTER: inferring non-covalent interactions in macromolecular structures from atomic coordinate data. Nucleic Acids Research. 32: W566-8. PMID 15215451 DOI: 10.1093/nar/gkh434  0.76
2004 Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN. Functional analysis of the Mad1-mSin3A repressor-corepressor interaction reveals determinants of specificity, affinity, and transcriptional response. Molecular and Cellular Biology. 24: 2698-709. PMID 15024060 DOI: 10.1128/MCB.24.7.2698-2709.2004  0.76
2003 Swanson KA, Kang RS, Stamenova SD, Hicke L, Radhakrishnan I. Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation. The Embo Journal. 22: 4597-606. PMID 12970172 DOI: 10.1093/emboj/cdg471  0.76
2003 Kang RS, Daniels CM, Francis SA, Shih SC, Salerno WJ, Hicke L, Radhakrishnan I. Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell. 113: 621-30. PMID 12787503 DOI: 10.1016/S0092-8674(03)00362-3  0.76
2002 Tai LJ, McFall SM, Huang K, Demeler B, Fox SG, Brubaker K, Radhakrishnan I, Morimoto RI. Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. The Journal of Biological Chemistry. 277: 735-45. PMID 11679589 DOI: 10.1074/jbc.M108604200  0.76
1999 Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Molecular and Cellular Biology. 19: 5601-7. PMID 10409749 DOI: 10.1128/MCB.19.8.5601  0.76
1997 Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE. Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA. Nature Structural Biology. 4: 605-8. PMID 9253405 DOI: 10.1038/nsb0897-605  0.76
1996 Greenbaum NL, Radhakrishnan I, Patel DJ, Hirsh D. Solution structure of the donor site of a trans-splicing RNA. Structure (London, England : 1993). 4: 725-33. PMID 8805553 DOI: 10.1016/S0969-2126(96)00078-0  0.76
1995 Greenbaum NL, Radhakrishnan I, Hirsh D, Patel DJ. Determination of the folding topology of the SL1 RNA from Caenorhabditis elegans by multidimensional heteronuclear NMR. Journal of Molecular Biology. 252: 314-27. PMID 7563053 DOI: 10.1006/jmbi.1995.0499  0.68
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