Christopher C. Glembotski - Publications

Biology (Joint Doctoral SDSU) University of California, San Diego, La Jolla, CA 
Cell Biology, General Biophysics

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Blackwood EA, Bilal AS, Azizi K, Sarakki A, Glembotski CC. Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart. Journal of Visualized Experiments : Jove. PMID 32597844 DOI: 10.3791/61224  0.68
2020 Blackwood EA, Thuerauf DJ, Stastna M, Stephens H, Sand Z, Pentoney A, Azizi K, Jakobi T, Van Eyk JE, Katus HA, Glembotski CC, Doroudgar S. Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response. Journal of Molecular and Cellular Cardiology. PMID 32339566 DOI: 10.1016/j.yjmcc.2020.04.012  1
2020 Arrieta A, Blackwood EA, Stauffer WT, Domingo MS, Bilal AS, Thuerauf DJ, Pentoney AN, Aivati C, Sarakki AV, Doroudgar S, Glembotski CC. Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart. The Journal of Biological Chemistry. PMID 32327487 DOI: 10.1074/jbc.RA120.013345  1
2020 Glembotski CC, Arrieta A, Blackwood EA, Stauffer WT. ATF6 as a Nodal Regulator of Proteostasis in the Heart. Frontiers in Physiology. 11: 267. PMID 32322217 DOI: 10.3389/fphys.2020.00267  0.68
2020 Palmer JE, Brietske BM, Bate TC, Blackwood EA, Garg M, Glembotski CC, Cooley CB. Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury. Acs Medicinal Chemistry Letters. 11: 292-297. PMID 32184959 DOI: 10.1021/acsmedchemlett.9b00299  0.68
2020 Blackwood EA, Bilal AS, Stauffer WT, Arrieta A, Glembotski CC. Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis. Cells. 9. PMID 32138230 DOI: 10.3390/cells9030602  0.68
2020 Stauffer WT, Blackwood EA, Azizi K, Kaufman RJ, Glembotski CC. The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts. International Journal of Molecular Sciences. 21. PMID 32085622 DOI: 10.3390/ijms21041373  0.68
2020 Stauffer WT, Arrieta A, Blackwood EA, Glembotski CC. Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α. International Journal of Molecular Sciences. 21. PMID 32046286 DOI: 10.3390/ijms21031134  0.68
2019 Arrieta A, Blackwood EA, Stauffer WT, Glembotski CC. Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart. Frontiers in Cardiovascular Medicine. 6: 193. PMID 32010709 DOI: 10.3389/fcvm.2019.00193  0.68
2019 Glembotski CC, Arrieta A, Blackwood EA. Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease. Journal of the American College of Cardiology. 73: 1807-1810. PMID 30975298 DOI: 10.1016/j.jacc.2018.12.089  0.68
2019 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1038/s41467-018-08129-2  0.84
2019 Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, Müller OJ, Jakobi T, Dieterich C, Katus HA, Doroudgar S, Glembotski CC. ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb. Circulation Research. 124: 79-93. PMID 30582446 DOI: 10.1161/CIRCRESAHA.118.313854  1
2017 Gray CB, Suetomi T, Xiang S, Blackwood EA, Glembotski CC, Miyamoto S, Daan Westenbrink B, Brown JH. CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α. Journal of Molecular and Cellular Cardiology. PMID 28077321 DOI: 10.1016/j.yjmcc.2017.01.002  0.68
2016 Jin JK, Blackwood EA, Azizi KM, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circulation Research. PMID 27932512 DOI: 10.1161/CIRCRESAHA.116.310266  1
2016 Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release. International Journal of Cardiology. 225: 371-380. PMID 27760414 DOI: 10.1016/j.ijcard.2016.10.021  1
2016 Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M. S100A4 protects the myocardium against ischemic stress. Journal of Molecular and Cellular Cardiology. PMID 27721024 DOI: 10.1016/j.yjmcc.2016.10.001  1
2015 Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC. Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circulation Research. 117: 536-46. PMID 26137860 DOI: 10.1161/CIRCRESAHA.115.306993  0.44
2014 Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA. PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. Embo Molecular Medicine. 6: 57-65. PMID 24408966 DOI: 10.1002/emmm.201303183  0.44
2013 Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA. Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage. Circulation. 128: 2132-44. PMID 24008870 DOI: 10.1161/CIRCULATIONAHA.113.003638  0.44
2013 Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA. Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 110: 12661-6. PMID 23842089 DOI: 10.1073/pnas.1301455110  0.44
2013 Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, et al. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circulation Research. 112: 1244-52. PMID 23487407 DOI: 10.1161/CIRCRESAHA.113.301084  0.44
2013 Doroudgar S, Glembotski CC. ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response. Circulation Research. 112: 9-12. PMID 23287452 DOI: 10.1161/CIRCRESAHA.112.280560  1
2013 Doroudgar S, Glembotski CC. New concepts of endoplasmic reticulum function in the heart: programmed to conserve. Journal of Molecular and Cellular Cardiology. 55: 85-91. PMID 23085588 DOI: 10.1016/j.yjmcc.2012.10.006  1
2012 Eletto D, Maganty A, Eletto D, Dersh D, Makarewich C, Biswas C, Paton JC, Paton AW, Doroudgar S, Glembotski CC, Argon Y. Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. Journal of Cell Science. 125: 4865-75. PMID 22854046 DOI: 10.1242/jcs.108928  0.44
2012 Glembotski CC, Thuerauf DJ, Huang C, Vekich JA, Gottlieb RA, Doroudgar S. Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion. The Journal of Biological Chemistry. 287: 25893-904. PMID 22637475 DOI: 10.1074/jbc.M112.356345  0.44
2012 Vekich JA, Belmont PJ, Thuerauf DJ, Glembotski CC. Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death. Journal of Molecular and Cellular Cardiology. 53: 259-67. PMID 22609432 DOI: 10.1016/j.yjmcc.2012.05.005  0.84
2012 Belmont PJ, Chen WJ, Thuerauf DJ, Glembotski CC. Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response. Journal of Molecular and Cellular Cardiology. 52: 1176-82. PMID 22326432 DOI: 10.1016/j.yjmcc.2012.01.017  0.84
2011 Doroudgar S, Glembotski CC. The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart. Trends in Molecular Medicine. 17: 207-14. PMID 21277256 DOI: 10.1016/j.molmed.2010.12.003  1
2010 Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, ... ... Glembotski CC, et al. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circulation Research. 106: 1265-74. PMID 20203306 DOI: 10.1161/CIRCRESAHA.109.212035  0.44
2010 Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Lowe NG, Gude N, Hilton B, Wolkowicz R, Sussman MA, Glembotski CC. Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene derlin-3 in the ischemic heart Circulation Research. 106: 307-316. PMID 19940266 DOI: 10.1161/CIRCRESAHA.109.203901  0.44
2009 Meex SJ, Weissglas-Volkov D, van der Kallen CJ, Thuerauf DJ, van Greevenbroek MM, Schalkwijk CG, Stehouwer CD, Feskens EJ, Heldens L, Ayoubi TA, Hofker MH, Wouters BG, Vlietinck R, Sinsheimer JS, Taskinen MR, ... ... Glembotski CC, et al. The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1322-7. PMID 19667116 DOI: 10.1161/ATVBAHA.108.180240  0.44
2009 Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC. Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. The Journal of Biological Chemistry. 284: 29735-45. PMID 19622751 DOI: 10.1074/jbc.M109.018036  1
2009 Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA. LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. American Journal of Physiology. Heart and Circulatory Physiology. 296: H470-9. PMID 19098111 DOI: 10.1152/ajpheart.01051.2008  0.44
2008 Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC. Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circulation Research. 103: 1249-58. PMID 18927462 DOI: 10.1161/CIRCRESAHA.108.180679  0.84
2008 Belmont PJ, Tadimalla A, Chen WJ, Martindale JJ, Thuerauf DJ, Marcinko M, Gude N, Sussman MA, Glembotski CC. Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. The Journal of Biological Chemistry. 283: 14012-21. PMID 18319259 DOI: 10.1074/jbc.M709776200  0.84
2007 Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, ... Glembotski CC, et al. Pim-1 regulates cardiomyocyte survival downstream of Akt Nature Medicine. 13: 1467-1475. PMID 18037896 DOI: 10.1038/nm1671  0.44
2007 Thuerauf DJ, Marcinko M, Belmont PJ, Glembotski CC. Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. The Journal of Biological Chemistry. 282: 22865-78. PMID 17522056 DOI: 10.1074/jbc.M701213200  0.84
2006 Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC. Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circulation Research. 99: 275-82. PMID 16794188 DOI: 10.1161/01.RES.0000233317.70421.03  0.44
2006 Wall JA, Wei J, Ly M, Belmont P, Martindale JJ, Tran D, Sun J, Chen WJ, Yu W, Oeller P, Briggs S, Gustafsson AB, Sayen MR, Gottlieb RA, Glembotski CC. Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2462-72. PMID 16766635 DOI: 10.1152/ajpheart.01311.2005  0.44
2006 Martindale JJ, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman MA, Glembotski CC. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circulation Research. 98: 1186-93. PMID 16601230 DOI: 10.1161/01.RES.0000220643.65941.8d  0.6
2005 Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA. Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. The Journal of Clinical Investigation. 115: 2716-30. PMID 16200208 DOI: 10.1172/JCI24280  0.44
2005 Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R, Glembotski CC. Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. The Journal of Biological Chemistry. 280: 669-76. PMID 15492008 DOI: 10.1074/jbc.M406690200  0.44
2004 Thuerauf DJ, Morrison L, Glembotski CC. Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. The Journal of Biological Chemistry. 279: 21078-84. PMID 14973138 DOI: 10.1074/jbc.M400713200  0.84
2004 Morrison LE, Whittaker RJ, Klepper RE, Wawrousek EF, Glembotski CC. Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. American Journal of Physiology. Heart and Circulatory Physiology. 286: H847-55. PMID 14592939 DOI: 10.1152/ajpheart.00715.2003  0.32
2003 Degousee N, Martindale J, Stefanski E, Cieslak M, Lindsay TF, Fish JE, Marsden PA, Thuerauf DJ, Glembotski CC, Rubin BB. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Circulation Research. 92: 757-64. PMID 12649265 DOI: 10.1161/01.RES.0000067929.01404.03  0.44
2003 Morrison LE, Hoover HE, Thuerauf DJ, Glembotski CC. Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circulation Research. 92: 203-11. PMID 12574148  0.84
2002 Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC. Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. The Journal of Biological Chemistry. 277: 20734-9. PMID 11909875 DOI: 10.1074/jbc.M201749200  0.84
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