Thanos D. Halazonetis - Publications

University of Pennsylvania, Philadelphia, PA, United States 
Bioinformatics Biology, General Biophysics, Molecular Biology

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Crefcoeur RP, Zgheib O, Halazonetis TD. A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System. Plos One. 12: e0169126. PMID 28046023 DOI: 10.1371/journal.pone.0169126  0.8
2016 Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, ... Halazonetis TD, et al. Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks. Molecular Cell. 64: 1127-1134. PMID 27984746 DOI: 10.1016/j.molcel.2016.10.038  0.64
2015 Kocy?owski MK, Rey AJ, Stewart GS, Halazonetis TD. Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle (Georgetown, Tex.). 14: 1748-58. PMID 25695757 DOI: 10.1080/15384101.2015.1010918  1
2014 Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi OP, Halazonetis TD. Break-induced replication repair of damaged forks induces genomic duplications in human cells Science. 343: 88-91. PMID 24310611 DOI: 10.1126/science.1243211  1
2013 Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, ... ... Halazonetis TD, et al. Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nature Cell Biology. 15: 967-77. PMID 23851489 DOI: 10.1038/ncb2795  0.64
2013 Crefcoeur RP, Yin R, Ulm R, Halazonetis TD. Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nature Communications. 4: 1779. PMID 23653191 DOI: 10.1038/ncomms2800  0.8
2012 Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H, Almusa H, Robyr D, Guipponi M, Saarela J, Gorgoulis VG, Antonarakis SE, Halazonetis TD. A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Research. 72: 6279-89. PMID 23204322 DOI: 10.1158/0008-5472.CAN-12-3869  0.64
2012 Nishimura T, Molinard G, Petty TJ, Broger L, Gabus C, Halazonetis TD, Thore S, Paszkowski J. Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. Plos Genetics. 8: e1002484. PMID 22346760 DOI: 10.1371/journal.pgen.1002484  1
2012 Nikolaev SI, Rimoldi D, Iseli C, Valsesia A, Robyr D, Gehrig C, Harshman K, Guipponi M, Bukach O, Zoete V, Michielin O, Muehlethaler K, Speiser D, Beckmann JS, Xenarios I, ... Halazonetis TD, et al. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nature Genetics. 44: 133-9. PMID 22197931 DOI: 10.1038/ng.1026  1
2011 Petty TJ, Emamzadah S, Costantino L, Petkova I, Stavridi ES, Saven JG, Vauthey E, Halazonetis TD. An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. The Embo Journal. 30: 2167-76. PMID 21522129 DOI: 10.1038/emboj.2011.127  1
2010 Gorgoulis VG, Halazonetis TD. Oncogene-induced senescence: the bright and dark side of the response. Current Opinion in Cell Biology. 22: 816-27. PMID 20807678 DOI: 10.1016/  0.64
2010 Petty TJ, Nishimura T, Emamzadah S, Gabus C, Paszkowski J, Halazonetis TD, Thore S. Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 916-8. PMID 20693667 DOI: 10.1107/S1744309110021068  1
2010 Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M, Halazonetis TD, Takeda S. DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken. The Journal of Cell Biology. 189: 1117-27. PMID 20584917 DOI: 10.1083/jcb.200912012  1
2010 Negrini S, Gorgoulis VG, Halazonetis TD. Genomic instability--an evolving hallmark of cancer. Nature Reviews. Molecular Cell Biology. 11: 220-8. PMID 20177397 DOI: 10.1038/nrm2858  0.64
2009 Emamzadah S, Petty TJ, De Almeida V, Nishimura T, Joly J, Ferrer JL, Halazonetis TD. Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction. Acta Crystallographica. Section D, Biological Crystallography. 65: 913-20. PMID 19690369 DOI: 10.1107/S0907444909021489  1
2009 Pataky K, Villanueva G, Liani A, Zgheib O, Jenkins N, Halazonetis DJ, Halazonetis TD, Brugger J. Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays. Radiation Research. 172: 252-9. PMID 19630530 DOI: 10.1667/RR1483.1  0.8
2009 Liontos M, Niforou K, Velimezi G, Vougas K, Evangelou K, Apostolopoulou K, Vrtel R, Damalas A, Kontovazenitis P, Kotsinas A, Zoumpourlis V, Tsangaris GT, Kittas C, Ginsberg D, Halazonetis TD, et al. Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. The American Journal of Pathology. 175: 376-91. PMID 19541929 DOI: 10.2353/ajpath.2009.081160  0.64
2009 Zgheib O, Pataky K, Brugger J, Halazonetis TD. An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Molecular and Cellular Biology. 29: 1050-8. PMID 19064641 DOI: 10.1128/MCB.01011-08  0.8
2008 Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science (New York, N.Y.). 319: 1352-5. PMID 18323444 DOI: 10.1126/science.1140735  0.64
2007 Tuttle RL, Bothos J, Summers MK, Luca FC, Halazonetis TD. Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network. Molecular Cancer Research : McR. 5: 1304-11. PMID 18171988 DOI: 10.1158/1541-7786.MCR-07-0388  0.56
2007 Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, ... ... Halazonetis TD, et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Research. 67: 10899-909. PMID 18006835 DOI: 10.1158/0008-5472.CAN-07-2837  0.64
2007 Venere M, Snyder A, Zgheib O, Halazonetis TD. Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function. Cancer Research. 67: 6100-5. PMID 17616665 DOI: 10.1158/0008-5472.CAN-07-0369  1
2007 Tsimaratou K, Kletsas D, Kastrinakis NG, Tsantoulis PK, Evangelou K, Sideridou M, Liontos M, Poulias I, Venere M, Salmas M, Kittas C, Halazonetis TD, Gorgoulis VG. Evaluation of claspin as a proliferation marker in human cancer and normal tissues. The Journal of Pathology. 211: 331-9. PMID 17152083 DOI: 10.1002/path.2095  1
2006 Halazonetis TD, Bartek J. DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter. Molecular Cell. 24: 809-10. PMID 17189183 DOI: 10.1016/j.molcel.2006.12.004  0.52
2006 Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, ... ... Halazonetis TD, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 444: 633-7. PMID 17136093 DOI: 10.1038/nature05268  0.64
2005 Livingstone M, Ruan H, Weiner J, Clauser KR, Strack P, Jin S, Williams A, Greulich H, Gardner J, Venere M, Mochan TA, DiTullio RA, Moravcevic K, Gorgoulis VG, Burkhardt A, ... Halazonetis TD, et al. Valosin-containing protein phosphorylation at Ser784 in response to DNA damage. Cancer Research. 65: 7533-40. PMID 16140914 DOI: 10.1158/0008-5472.CAN-04-3729  1
2005 Bothos J, Tuttle RL, Ottey M, Luca FC, Halazonetis TD. Human LATS1 is a mitotic exit network kinase. Cancer Research. 65: 6568-75. PMID 16061636 DOI: 10.1158/0008-5472.CAN-05-0862  0.56
2005 Zgheib O, Huyen Y, DiTullio RA, Snyder A, Venere M, Stavridi ES, Halazonetis TD. ATM signaling and 53BP1. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 76: 119-22. PMID 16024119 DOI: 10.1016/j.radonc.2005.06.026  1
2005 Stavridi ES, Halazonetis TD. Nbs1 moving up in the world. Nature Cell Biology. 7: 648-50. PMID 15990895 DOI: 10.1038/ncb0705-648  0.72
2005 Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 434: 907-13. PMID 15829965 DOI: 10.1038/nature03485  1
2005 Summers MK, Bothos J, Halazonetis TD. The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus. Oncogene. 24: 2589-98. PMID 15674323 DOI: 10.1038/sj.onc.1208428  0.56
2004 Huyen Y, Zgheib O, Ditullio RA, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature. 432: 406-11. PMID 15525939 DOI: 10.1038/nature03114  1
2004 MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T. Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. The Embo Journal. 23: 3689-99. PMID 15343266 DOI: 10.1038/sj.emboj.7600363  1
2004 Mochan TA, Venere M, DiTullio RA, Halazonetis TD. 53BP1, an activator of ATM in response to DNA damage. Dna Repair. 3: 945-52. PMID 15279780 DOI: 10.1016/j.dnarep.2004.03.017  1
2004 Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD. Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure (London, England : 1993). 12: 1237-43. PMID 15242600 DOI: 10.1016/j.str.2004.05.007  1
2004 Stavridi ES, Halazonetis TD. p53 and stress in the ER. Genes & Development. 18: 241-4. PMID 14871924 DOI: 10.1101/gad.1181704  0.72
2003 Mochan TA, Venere M, DiTullio RA, Halazonetis TD. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Research. 63: 8586-91. PMID 14695167  1
2003 Mariatos G, Bothos J, Zacharatos P, Summers MK, Scolnick DM, Kittas C, Halazonetis TD, Gorgoulis VG. Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer. Cancer Research. 63: 7185-9. PMID 14612512  1
2003 Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD. The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene. 22: 7101-7. PMID 14562038 DOI: 10.1038/sj.onc.1206831  1
2003 Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS. Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis. 24: 47-51. PMID 12538348 DOI: 10.1093/carcin/24.1.47  1
2002 DiTullio RA, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biology. 4: 998-1002. PMID 12447382 DOI: 10.1038/ncb892  1
2002 Venere M, Mochan TA, Halazonetis TD. Chk2 leaves the PML depot. Nature Cell Biology. 4: E255-6. PMID 12415282 DOI: 10.1038/ncb1102-e255  1
2002 Stavridi ES, Huyen Y, Loreto IR, Scolnick DM, Halazonetis TD, Pavletich NP, Jeffrey PD. Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate Structure. 10: 891-899. PMID 12121644 DOI: 10.1016/S0969-2126(02)00776-1  1
2000 Schultz LB, Chehab NH, Malikzay A, DiTullio RA, Stavridi ES, Halazonetis TD. The DNA damage checkpoint and human cancer. Cold Spring Harbor Symposia On Quantitative Biology. 65: 489-98. PMID 12760066  1
2000 Scolnick DM, Halazonetis TD. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature. 406: 430-5. PMID 10935642 DOI: 10.1038/35019108  1
1999 Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Molecular and Cellular Biology. 19: 1202-9. PMID 9891054  1
1997 Scolnick DM, Chehab NH, Stavridi ES, Lien MC, Caruso L, Moran E, Berger SL, Halazonetis TD. CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Research. 57: 3693-6. PMID 9288775  1
1997 Candau R, Scolnick DM, Darpino P, Ying CY, Halazonetis TD, Berger SL. Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene. 15: 807-16. PMID 9266967 DOI: 10.1038/sj.onc.1201244  1
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