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Amato J. Giaccia - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Oncology, Cell Biology, Animal Physiology Biology
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Year Citation  Score
2023 Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar DK, Kim RK, Valbuena GN, Guglietta S, Krieg C, Darvish-Damavandi M, Suwa T, Easton A, Hillson LV, McCulloch AK, McMahon RK, ... ... Giaccia AJ, et al. Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. The Journal of Clinical Investigation. PMID 37824211 DOI: 10.1172/JCI168277  0.468
2022 Sodji QH, Nambiar DK, Viswanathan V, von Eyben R, Colburg D, Binkley MS, Li CG, Olcina MM, Chang DT, Le QT, Giaccia AJ. The Combination of Radiotherapy and Complement C3a Inhibition Potentiates Natural Killer cell Functions Against Pancreatic Cancer. Cancer Research Communications. 2: 725-738. PMID 35937458 DOI: 10.1158/2767-9764.crc-22-0069  0.742
2022 Miao YR, Thakkar K, Cenik C, Jiang D, Mizuno K, Jia C, Li CG, Zhao H, Diep A, Xu Y, Zhang XE, Yang TTC, Liedtke M, Abidi P, Leung WS, ... ... Giaccia AJ, et al. Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma. The Journal of Experimental Medicine. 219. PMID 35881112 DOI: 10.1084/jem.20220214  0.422
2021 Mehibel M, Xu Y, Li CG, Moon EJ, Thakkar KN, Diep AN, Kim RK, Bloomstein JD, Xiao Y, Bacal J, Saldivar JC, Le QT, Cimprich KA, Rankin EB, Giaccia AJ. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. The Journal of Clinical Investigation. 131. PMID 34060485 DOI: 10.1172/JCI146256  0.34
2020 Olcina MM, Kim RK, Balanis NG, Li CG, von Eyben R, Graeber TG, Ricklin D, Stucki M, Giaccia AJ. Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis. Iscience. 23: 101594. PMID 33205012 DOI: 10.1016/j.isci.2020.101594  0.799
2020 Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, ... Giaccia AJ, et al. The mA RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817424 DOI: 10.1073/Pnas.2000516117  0.445
2020 Klockow JL, Hettie KS, LaGory EL, Moon EJ, Giaccia AJ, Graves EE, Chin FT. An Activatable NIR Fluorescent Rosol for Selectively Imaging Nitroreductase Activity. Sensors and Actuators. B, Chemical. 306. PMID 32265579 DOI: 10.1016/J.Snb.2019.127446  0.348
2020 Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JA, Jeffrey SS, Giaccia AJ. Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 579: 456. PMID 32188947 DOI: 10.1038/S41586-020-2112-4  0.304
2020 Aguilera TA, Elghonaimy E, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong A, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. Induced tumor heterogeneity reveals factors informing radiation and immunotherapy combinations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32098769 DOI: 10.1158/1078-0432.Ccr-19-4220  0.516
2020 Li Y, Gruber JJ, Litzenburger UM, Zhou Y, Miao YR, LaGory EL, Li AM, Hu Z, Yip M, Hart LS, Maris JM, Chang HY, Giaccia AJ, Ye J. Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell Death & Disease. 11: 102. PMID 32029721 DOI: 10.1038/S41419-020-2303-9  0.388
2019 Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, ... ... Giaccia A, et al. Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. The Journal of Clinical Investigation. PMID 31710313 DOI: 10.1172/Jci129025  0.539
2019 Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB. S100A10 is a critical mediator of GAS6/AXL-induced angiogenesis in renal cell carcinoma. Cancer Research. PMID 31585940 DOI: 10.1158/0008-5472.Can-19-1366  0.406
2019 Wu PH, Onodera Y, Recuenco FC, Giaccia AJ, Le QT, Shimizu S, Shirato H, Nam JM. Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition. Cancers. 11. PMID 31426369 DOI: 10.3390/Cancers11081192  0.375
2019 VandeKopple MJ, Wu J, Auer EN, Giaccia AJ, Denko NC, Papandreou I. HILPDA regulates lipid metabolism, lipid droplet abundance and response to microenvironmental stress in solid tumors. Molecular Cancer Research : McR. PMID 31308147 DOI: 10.1158/1541-7786.Mcr-18-1343  0.351
2019 Yao Q, Khan MP, Merceron C, LaGory EL, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E. Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate. Developmental Cell. PMID 31105007 DOI: 10.1016/J.Devcel.2019.04.029  0.327
2019 Hu MS, Maan ZN, Leavitt T, Hong WX, Rennert RC, Marshall CD, Borrelli MR, Zhu TN, Esquivel M, Zimmermann A, McArdle A, Chung MT, Foster DS, Jones RE, Gurtner GC, ... Giaccia AJ, et al. Wounds Inhibit Tumor Growth In Vivo. Annals of Surgery. PMID 30829705 DOI: 10.1097/Sla.0000000000003255  0.326
2019 Merceron C, Ranganathan K, Wang E, Tata Z, Makkapati S, Khan MP, Mangiavini L, Yao AQ, Castellini L, Levi B, Giaccia AJ, Schipani E. Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual. Bone Research. 7: 7. PMID 30792937 DOI: 10.1038/S41413-019-0045-Z  0.336
2019 McGee HM, Jiang D, Soto-Pantoja DR, Nevler A, Giaccia AJ, Woodward WA. Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30723144 DOI: 10.1158/1078-0432.Ccr-18-3781  0.39
2019 Mehibel M, Xu J, Diep A, Thakkar K, Li CG, Xiao Y, Rankin E, Giaccia A. Modulating the tumor microenvironment to enhance efficacy of PARP inhibitors. Journal of Clinical Oncology. 37: e14715-e14715. DOI: 10.1200/Jco.2019.37.15_Suppl.E14715  0.439
2019 Olcina MM, Balanis NG, Kim RK, Thompson MJ, Graeber TG, Giaccia AJ. Abstract A097: Complement system mutations in cancer: Uncovering new relationships between tumor hypoxia and complement Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A097  0.584
2019 Li Y, Zhou Y, Maris JM, Giaccia AJ, Ye J. Abstract 3798: Acetate supplementation eliminates hypoxia mediated resistance to differentiation therapy in neuroblastoma cells Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3798  0.314
2019 Hacker BC, Alves SM, Jiang D, Koong AC, Giaccia AJ, Graves EE, Rafat M. Abstract 3931: The irradiated tissue microenvironment and its role in breast cancer recurrence: Enhanced macrophage infiltration promotes tumor cell recruitment Cancer Research. 79: 3931-3931. DOI: 10.1158/1538-7445.Am2019-3931  0.537
2019 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le Q, Koong AC, Giaccia AJ, Chen C, Yu B, Papandreou I, Denko NC. Abstract 2927: Papaverine and its novel derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism Cancer Research. 79: 2927-2927. DOI: 10.1158/1538-7445.Am2019-2927  0.572
2018 Olcina MM, Balanis NG, Kim RK, Aksoy BA, Kodysh J, Thompson MJ, Hammerbacher J, Graeber TG, Giaccia AJ. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Reports. 25: 3721-3732.e6. PMID 30590044 DOI: 10.1016/J.Celrep.2018.11.093  0.808
2018 Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon C, Semenza GL, et al. Endothelial HIF-2α is Required for the Maintenance of Airway Microvasculature. Circulation. PMID 30586708 DOI: 10.1161/Circulationaha.118.036157  0.32
2018 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Erratum: Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism (Proceedings of the National Academy of Sciences of the United States of America (2018) 115 (10756–10761) DOI: 10.1073/pnas.1808945115) Proceedings of the National Academy of Sciences of the United States of America. 115. PMID 30455291 DOI: 10.1073/Pnas.1818732115  0.464
2018 Chen X, Litzenburger UM, Wei Y, Schep AN, LaGory EL, Choudhry H, Giaccia AJ, Greenleaf WJ, Chang HY. Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Nature Communications. 9: 4590. PMID 30389926 DOI: 10.1038/S41467-018-07115-Y  0.398
2018 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen SC, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 30201710 DOI: 10.1073/Pnas.1808945115  0.55
2018 Rafat M, Aguilera TA, Vilalta M, Bronsart LL, Soto LA, von Eyben R, Golla MA, Ahrari Y, Melemenidis S, Afghahi A, Jenkins MJ, Kurian AW, Horst K, Giaccia AJ, Graves EE. Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients. Cancer Research. PMID 29880480 DOI: 10.1158/0008-5472.Can-17-3623  0.348
2018 Olcina MM, Kim RK, Melemenidis S, Graves EE, Giaccia AJ. The tumour microenvironment links complement system dysregulation and hypoxic signalling. The British Journal of Radiology. 20180069. PMID 29544344 DOI: 10.1259/Bjr.20180069  0.766
2018 Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Molecular Cancer Research : McR. PMID 29440447 DOI: 10.1158/1541-7786.Mcr-17-0307  0.525
2018 Ko SH, Nauta AC, Morrison SD, Hu MS, Zimmermann AS, Chung MT, Glotzbach JP, Wong VW, Walmsley GG, Peter Lorenz H, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. Plastic and Reconstructive Surgery. 141: 55e-67e. PMID 29280872 DOI: 10.1097/Prs.0000000000003959  0.671
2018 Olcina MM, Balanis NG, Kim RK, Thompson MJ, Graeber TG, Giaccia AJ. Abstract 4382: Complement system mutational landscape reveals C4BPA mutations enhance apoptosis in an immune-independent manner Cancer Research. 78: 4382-4382. DOI: 10.1158/1538-7445.Am2018-4382  0.569
2018 Marquez C, Kim J, Giaccia A, Cochran J, Sweet-Cordero A. Abstract 3918: Targeting the CLCF1-CNTFR signaling axis using directed evolution for lung cancer therapy Cancer Research. 78: 3918-3918. DOI: 10.1158/1538-7445.Am2018-3918  0.406
2018 Wu P, Onodera Y, Giaccia AJ, Le Q, Shirato H, Nam J. Abstract 3202: Radiation increases invasive activity of breast cancer cells via altering lysosome exocytosis Cancer Research. 78: 3202-3202. DOI: 10.1158/1538-7445.Am2018-3202  0.338
2017 Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM. Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells. International Journal of Nanomedicine. 12: 5069-5085. PMID 28860745 DOI: 10.2147/Ijn.S137833  0.358
2017 Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, ... Giaccia AJ, et al. Blimp1 induces transient metastatic heterogeneity in pancreatic cancer. Cancer Discovery. PMID 28790031 DOI: 10.1158/2159-8290.Cd-17-0250  0.552
2017 VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia A, Denko N, Papandreou I. Stress-responsive HILPDA is necessary for thermoregulation during fasting. The Journal of Endocrinology. PMID 28739822 DOI: 10.1530/Joe-17-0289  0.309
2017 Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, et al. Pre-metastatic niches: organ-specific homes for metastases. Nature Reviews. Cancer. PMID 28303905 DOI: 10.1038/Nrc.2017.6  0.301
2017 Aguilera TA, Giaccia AJ. Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion- A New Role for the AXL Receptor Tyrosine Kinase. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28289089 DOI: 10.1158/1078-0432.Ccr-17-0189  0.35
2017 Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Research. PMID 28073943 DOI: 10.1093/Nar/Gkw1281  0.394
2016 Rankin EB, Nam JM, Giaccia AJ. Hypoxia: Signaling the Metastatic Cascade. Trends in Cancer. 2: 295-304. PMID 28741527 DOI: 10.1016/J.Trecan.2016.05.006  0.439
2016 Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nature Communications. 7: 13898. PMID 28008921 DOI: 10.1038/Ncomms13898  0.511
2016 Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. The Journal of Clinical Investigation. PMID 27893463 DOI: 10.1172/Jci85610  0.779
2016 Rankin EB, Giaccia AJ. The Receptor Tyrosine Kinase AXL in Cancer Progression. Cancers. 8. PMID 27834845 DOI: 10.3390/Cancers8110103  0.375
2016 Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nature Cell Biology. 18: 1260. PMID 27784904 DOI: 10.1038/ncb3433  0.704
2016 Vilalta M, Hughes NP, Von Eyben R, Giaccia AJ, Graves EE. Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 27709411 DOI: 10.1007/S11307-016-1010-5  0.34
2016 Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nature Cell Biology. PMID 27642788 DOI: 10.1038/Ncb3408  0.73
2016 Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response. Scientific Reports. 6: 33353. PMID 27634301 DOI: 10.1038/Srep33353  0.534
2016 Olcina MM, Giaccia AJ. Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis. The Journal of Clinical Investigation. PMID 27548524 DOI: 10.1172/Jci84432  0.755
2016 Giaccia AJ. A New Chromatin-Cytoskeleton Link in Cancer. Molecular Cancer Research : McR. PMID 27528705 DOI: 10.1158/1541-7786.Mcr-16-0250  0.318
2016 Sun RC, Koong A, Giaccia A, Denko NC. Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells. Advances in Experimental Medicine and Biology. 899: 113-20. PMID 27325264 DOI: 10.1007/978-3-319-26666-4_7  0.475
2016 Olcina MM, Giaccia AJ, Hammond EM. Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions. Advances in Experimental Medicine and Biology. 899: 27-40. PMID 27325260 DOI: 10.1007/978-3-319-26666-4_3  0.781
2016 Jiang D, Tam A, Alagappan M, Hay MP, Gupta A, Kozak M, Solow-Cordero DE, Lum PY, Denko N, Giaccia AJ, Le QT, Niwa M, Koong AC. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma. Molecular Cancer Therapeutics. PMID 27307600 DOI: 10.1158/1535-7163.Mct-15-1023  0.479
2016 Rankin EB, Giaccia AJ. Hypoxic control of metastasis. Science (New York, N.Y.). 352: 175-80. PMID 27124451 DOI: 10.1126/Science.Aaf4405  0.449
2016 LaGory EL, Giaccia AJ. The ever-expanding role of HIF in tumour and stromal biology. Nature Cell Biology. 18: 356-65. PMID 27027486 DOI: 10.1038/Ncb3330  0.373
2016 Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Scientific Reports. 6: 21698. PMID 26875667 DOI: 10.1038/Srep21698  0.822
2016 Ager C, Reilley M, Nicholas C, Bartkowiak T, Jaiswal A, Curran M, Albershardt TC, Bajaj A, Archer JF, Reeves RS, Ngo LY, Berglund P, ter Meulen J, Denis C, Ghadially H, ... ... Giaccia A, et al. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two Journal For Immunotherapy of Cancer. 4. DOI: 10.1186/S40425-016-0173-6  0.434
2016 Olcina MM, Giaccia AJ. Abstract B141: Targeting the complement system to improve radiation treatment Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B141  0.374
2016 Rafat M, Vilalta M, Aguilera TA, Giaccia AJ, Graves EE. Abstract 5124: Tumor and immune cell infiltration are enhanced by irradiation of normal tissues in immunocompromised mice Cancer Research. 76: 5124-5124. DOI: 10.1158/1538-7445.Am2016-5124  0.388
2016 Aguilera TA, Rafat MR, Castellini L, Kariolis MS, vonEbyen R, Graves EE, Giaccia AJ. Abstract 4988: Reprogramming the immunologic microenvironment through radiation and Axl targeting Cancer Research. 76: 4988-4988. DOI: 10.1158/1538-7445.Am2016-4988  0.393
2016 Soto LA, Rafat M, Colomer MV, Giaccia A, Graves E. Abstract 1645: Tumor-associated macrophages enhance DNA damage repair and improve survival of murine breast cancers after irradiation Cancer Research. 76: 1645-1645. DOI: 10.1158/1538-7445.Am2016-1645  0.382
2016 Moon EJ, Mello SS, Chi J, Krieg AJ, Giaccia A. Abstract 1628: MAFF, a new hypoxia target gene involving tumor invasion and metastasis Cancer Research. 76: 1628-1628. DOI: 10.1158/1538-7445.Am2016-1628  0.455
2016 Rankin EB, Nam JM, Giaccia AJ. Hypoxia: Signaling the Metastatic Cascade Trends in Cancer. 2: 295-304. DOI: 10.1016/j.trecan.2016.05.006  0.327
2015 Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, ... ... Giaccia AJ, et al. Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma. Oncogene. PMID 26364599 DOI: 10.1038/Onc.2015.343  0.387
2015 Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and Hypoxia-Inducible Factor-1α-Dependent Tumors of the Soft Tissue on Loss of Von Hippel-Lindau in Mesenchymal Progenitors. The American Journal of Pathology. 185: 3090-101. PMID 26348575 DOI: 10.1016/J.Ajpath.2015.07.008  0.394
2015 LaGory EL, Wu C, Taniguchi CM, Ding CC, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ. Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Reports. PMID 26119730 DOI: 10.1016/J.Celrep.2015.06.006  0.356
2015 Pollom EL, Deng L, Pai RK, Brown JM, Giaccia A, Loo BW, Shultz DB, Le QT, Koong AC, Chang DT. Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics. 92: 568-576. PMID 26068491 DOI: 10.1016/J.Ijrobp.2015.02.016  0.47
2015 Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging Treatment Paradigms in Radiation Oncology. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 3393-401. PMID 25991820 DOI: 10.1158/1078-0432.Ccr-14-1191  0.482
2015 Wu C, Rankin EB, Castellini L, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes & Development. 29: 817-31. PMID 25846796 DOI: 10.1101/Gad.255000.114  0.311
2015 Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4441-6. PMID 25792458 DOI: 10.1073/Pnas.1418164112  0.797
2015 Jiang D, LaGory EL, Kenzelmann Brož D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ, Attardi LD. Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Reports. 10: 1096-109. PMID 25704813 DOI: 10.1016/J.Celrep.2015.01.043  0.362
2015 Johnson RW, Schipani E, Giaccia AJ. HIF targets in bone remodeling and metastatic disease. Pharmacology & Therapeutics. 150: 169-77. PMID 25681658 DOI: 10.1016/J.Pharmthera.2015.02.002  0.36
2015 Moon EJ, Giaccia A. Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment. Free Radical Biology & Medicine. 79: 292-9. PMID 25458917 DOI: 10.1016/J.Freeradbiomed.2014.11.009  0.381
2015 Aguilera T, Rafat M, Kariolis M, von Eyben R, Graves E, Giaccia A. Tumor immunologic heterogeneity influences response to radiation and combination immunotherapy Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P345  0.349
2015 Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging treatment paradigms in radiation oncology Clinical Cancer Research. 21: 3393-3401. DOI: 10.1158/1078-0432.CCR-14-1191  0.417
2015 Hu MS, Maan ZN, Hong WX, Walmsley GG, Rennert RC, Atashroo D, Gurtner GC, Giaccia AJ, Lorenz HP, Longaker MT. Wounds outcompete tumors for neovascularization Journal of the American College of Surgeons. 221: e124. DOI: 10.1016/J.Jamcollsurg.2015.08.230  0.306
2014 Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia AJ, Koong AC, Diehn M, Le QT. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5558-69. PMID 25189484 DOI: 10.1158/1078-0432.Ccr-14-1138  0.522
2014 Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proceedings of the National Academy of Sciences of the United States of America. 111: 13373-8. PMID 25187556 DOI: 10.1073/Pnas.1404848111  0.425
2014 Giaccia AJ. Molecular radiobiology: the state of the art. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 2871-8. PMID 25113768 DOI: 10.1200/Jco.2014.57.2776  0.373
2014 Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT. Neurotrophic factor GDNF promotes survival of salivary stem cells. The Journal of Clinical Investigation. 124: 3364-77. PMID 25036711 DOI: 10.1172/Jci74096  0.51
2014 Vilalta M, Rafat M, Giaccia AJ, Graves EE. Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell Reports. 8: 402-9. PMID 25017065 DOI: 10.1016/J.Celrep.2014.06.011  0.372
2014 Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Developmental Biology. 393: 124-36. PMID 24972088 DOI: 10.1016/J.Ydbio.2014.06.013  0.343
2014 Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Science Translational Medicine. 6: 236ra64. PMID 24828078 DOI: 10.1126/Scitranslmed.3008523  0.336
2014 Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Advances in Experimental Medicine and Biology. 772: v-viii. PMID 24765667 DOI: 10.1007/978-1-4614-5915-6  0.679
2014 Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury. Plos One. 9: e93373. PMID 24695462 DOI: 10.1371/Journal.Pone.0093373  0.68
2014 Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP. Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents. Bioorganic & Medicinal Chemistry. 22: 711-20. PMID 24387866 DOI: 10.1016/J.Bmc.2013.12.028  0.622
2014 Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Molecular and Cellular Biology. 34: 739-51. PMID 24344197 DOI: 10.1128/Mcb.00644-12  0.467
2014 Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB. CTGF is a therapeutic target for metastatic melanoma. Oncogene. 33: 1093-100. PMID 23435419 DOI: 10.1038/Onc.2013.47  0.384
2014 Picozzi VJ, Pipas JM, Koong A, Giaccia A, Bahary N, Krishnamurthi SS, Lopez CD, O'Dwyer PJ, Modelska K, Carney M, Hernandez H, Chou J, Lee T, Zhong M, Porter S, et al. FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF), with gemcitabine/erlotinib (G/E) in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC). Journal of Clinical Oncology. 32: 4138-4138. DOI: 10.1200/Jco.2014.32.15_Suppl.4138  0.455
2014 Kuo P, Bratman S, Shultz D, Eyben Rv, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia A, Koong A, Diehn M, Le Q. Abstract 848: Galectin-1 mediates radiation-related lymphopenia in non-small cell lung cancer and attenuates tumor radiation response Cancer Research. 74: 848-848. DOI: 10.1158/1538-7445.Am2014-848  0.557
2014 Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. Abstract 1181: The Apoptosis repressor with a CARD domain (ARC) is a direct HIF1 target gene and promotes survival and proliferation of VHL deficient renal cancer cells Cancer Research. 74: 1181-1181. DOI: 10.1158/1538-7445.Am2014-1181  0.454
2014 Rafat M, Vilalta Colomer M, Giaccia A, Graves E. Normal Tissue Irradiation Promotes Tumor Cell Migration International Journal of Radiation Oncology*Biology*Physics. 90: S771-S772. DOI: 10.1016/J.Ijrobp.2014.05.2233  0.362
2013 Giaccia AJ. HIF-2: the missing link between obesity and cardiomyopathy. Journal of the American Heart Association. 2: e000710. PMID 24342999 DOI: 10.1161/Jaha.113.000710  0.344
2013 Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4455-64. PMID 23812668 DOI: 10.1158/1078-0432.Ccr-13-0127  0.504
2013 LaGory EL, Giaccia AJ. A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth. Cell Cycle (Georgetown, Tex.). 12: 718-9. PMID 23422857 DOI: 10.4161/Cc.23948  0.361
2013 Picozzi VJ, Pipas JM, Koong A, Giaccia A, Bahary N, Krishnamurthi SS, Lopez CD, O'Dwyer PJ, Modelska K, Poolman V, Chou J, Zhong M, Porter S, Neff T, Valone F. FG-3019, a human monoclonal antibody to CTGF, with gemcitabine/erlotinib in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma. Journal of Clinical Oncology. 31: 213-213. DOI: 10.1200/Jco.2013.31.4_Suppl.213  0.444
2013 Hu MS, Zimmermann AS, Chung MT, McArdle A, Rennert RC, Lai TS, Gurtner GC, Giaccia AJ, Lorenz HP, Longaker MT. In vivo tumor inhibition by full thickness wounds Journal of the American College of Surgeons. 217: S95. DOI: 10.1016/J.Jamcollsurg.2013.07.215  0.322
2012 Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget. 3: 1220-35. PMID 23100451 DOI: 10.18632/Oncotarget.714  0.313
2012 Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, et al. State of the science: an update on renal cell carcinoma. Molecular Cancer Research : McR. 10: 859-80. PMID 22638109 DOI: 10.1158/1541-7786.Mcr-12-0117  0.353
2012 Krieg SA, Fan X, Hong Y, Sang QX, Giaccia A, Westphal LM, Lathi RB, Krieg AJ, Nayak NR. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Molecular Human Reproduction. 18: 442-50. PMID 22505054 DOI: 10.1093/Molehr/Gas017  0.3
2012 Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 149: 63-74. PMID 22464323 DOI: 10.1016/J.Cell.2012.01.051  0.324
2012 Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia AJ, Haigh JJ, Carmeliet G, Schipani E. VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 596-609. PMID 22162090 DOI: 10.1002/Jbmr.1487  0.36
2012 Lim AM, Rischin D, Fisher R, Cao H, Kwok K, Truong D, McArthur GA, Young RJ, Giaccia A, Peters L, Le QT. Prognostic significance of plasma osteopontin in patients with locoregionally advanced head and neck squamous cell carcinoma treated on TROG 02.02 phase III trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 301-7. PMID 22096023 DOI: 10.1158/1078-0432.Ccr-11-2295  0.313
2012 Laderoute K, Calaoagan J, Mendonca H, Ausserer W, Chen E, Giaccia A, Sutherland R. Early responses of SiHa human squamous carcinoma cells to hypoxic signals. International Journal of Oncology. 8: 875-82. PMID 21544440 DOI: 10.3892/Ijo.8.5.875  0.631
2012 Denko N, Chen E, Laderoute K, Stambrook P, Giaccia A. Protease inhibitor TPCK represses Ha-ras (Val12) transformation and nuclear factor-kappa B activation. International Journal of Oncology. 10: 895-900. PMID 21533459 DOI: 10.3892/Ijo.10.5.895  0.316
2012 Chan D, Pearson P, Vernier J, Hershenson S, Freddo J, Tabibiazar R, Giaccia A, O'Connor P. 571 Targeting the GLUT1 Transporter as a Novel Therapeutic Approach to Exploit the Dependency of Cancer Cells On the “Warburg Effect” European Journal of Cancer. 48: 175. DOI: 10.1016/S0959-8049(12)72368-7  0.636
2012 Castellini L, Krieg A, Mello S, Giaccia A. 618 Identification of Novel p53-regulated Genes Involved in Chromatin Remodeling in Response to DNA Damage European Journal of Cancer. 48: S147. DOI: 10.1016/S0959-8049(12)71270-4  0.312
2012 Razorenova O, Colavitti R, Castellini L, Edgington L, Huang X, Nicolau M, Bedogni B, Mills E, Bogyo M, Giaccia A. 499 The Apoptosis Repressor With a CARD Domain (ARC) is Essential for the Survival of VHL Deficient Renal Cancer Cells European Journal of Cancer. 48: S120. DOI: 10.1016/S0959-8049(12)71167-X  0.303
2011 Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC. Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation. 124: S46-54. PMID 21911818 DOI: 10.1161/Circulationaha.110.014019  0.373
2011 Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, ... ... Giaccia AJ, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine. 3: 94ra70. PMID 21813754 DOI: 10.1126/Scitranslmed.3002394  0.77
2011 Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic & Medicinal Chemistry. 19: 3347-56. PMID 21561782 DOI: 10.1016/J.Bmc.2011.04.042  0.652
2011 Banh A, Zhang J, Cao H, Bouley DM, Kwok S, Kong C, Giaccia AJ, Koong AC, Le QT. Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Research. 71: 4423-31. PMID 21546572 DOI: 10.1158/0008-5472.Can-10-4157  0.554
2011 Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nature Reviews. Drug Discovery. 10: 351-64. PMID 21532565 DOI: 10.1038/Nrd3374  0.642
2011 Welford SM, Giaccia AJ. Hypoxia and senescence: the impact of oxygenation on tumor suppression. Molecular Cancer Research : McR. 9: 538-44. PMID 21385881 DOI: 10.1158/1541-7786.Mcr-11-0065  0.415
2011 Rankin EB, Giaccia AJ, Schipani E. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Current Osteoporosis Reports. 9: 46-52. PMID 21360287 DOI: 10.1007/S11914-011-0047-2  0.379
2011 Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proceedings of the National Academy of Sciences of the United States of America. 108: 1931-6. PMID 21233420 DOI: 10.1073/Pnas.1011777108  0.412
2011 Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. Abstract LB-357: HIF-dependent over-expression of CUB domain-containing protein 1 stimulates migration in clear cell renal cell carcinoma Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-357  0.319
2011 Cheng C, Giaccia AJ, Powell MB. Abstract 3412: Hypoxia induces EMT in primary melanoma and MET in metastatic melanoma Cancer Research. 71: 3412-3412. DOI: 10.1158/1538-7445.Am2011-3412  0.44
2011 Banh A, Zhang J, Cao H, Bouley D, Kwok S, Kong C, Giaccia A, Koong A, Le Q. Abstract 1557: Tumor Galectin-1 mediates lung cancer growth and metastasis through immunoregulation of T-cell apoptosis Cancer Research. 71: 1557-1557. DOI: 10.1158/1538-7445.Am2011-1557  0.556
2011 Finger EC, Banh A, Rankin EB, Vilalta M, Krieg AJ, Broome-Powell M, Giaccia AJ. Abstract 1460: AKAP12 regulates melanoma tumor growth and metastasis Cancer Research. 71: 1460-1460. DOI: 10.1158/1538-7445.Am2011-1460  0.413
2011 Banh A, Zhang J, Cao H, Bouley D, Kwok S, Kong C, Giaccia A, Koong A, Le Q. 255 INVITED Targeting Galectin-1, a Hypoxia Induced Protein, in Non-Small Cell Lung Cancers European Journal of Cancer. 47. DOI: 10.1016/S0959-8049(11)70470-1  0.504
2011 Ko S, Nauta A, Huang M, Chan D, Gurtner G, Wu J, Giaccia A, Longaker M. Novel Prolyl Hydroxylase Domain-2 Short Hairpin RNA Interference Therapy For Diabetic Wound Healing Journal of Surgical Research. 165: 187. DOI: 10.1016/J.Jss.2010.11.630  0.587
2011 Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia A, Haigh J, Carmeliet G, Schipani E. HIF-1a and VEGF promote chondrocyte survival via complementary mechanisms regulating the oxygen level in the avascular developing growth cartilage Bone. 48: S68. DOI: 10.1016/J.Bone.2011.03.062  0.321
2010 Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ. AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Research. 70: 7570-9. PMID 20858715 DOI: 10.1158/0008-5472.Can-10-1267  0.364
2010 Welford SM, Dorie MJ, Li X, Haase VH, Giaccia AJ. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Molecular and Cellular Biology. 30: 4595-603. PMID 20679489 DOI: 10.1128/Mcb.01618-09  0.363
2010 Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Molecular Biology of the Cell. 21: 3247-57. PMID 20660157 DOI: 10.1091/Mbc.E10-01-0025  0.66
2010 Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. The Journal of Biological Chemistry. 285: 26852-60. PMID 20581113 DOI: 10.1074/Jbc.M110.147041  0.676
2010 Giaccia AJ, Schipani E. Role of carcinoma-associated fibroblasts and hypoxia in tumor progression. Current Topics in Microbiology and Immunology. 345: 31-45. PMID 20517716 DOI: 10.1007/82_2010_73  0.411
2010 Chan DA, Giaccia AJ. PHD2 in tumour angiogenesis. British Journal of Cancer. 103: 1-5. PMID 20461086 DOI: 10.1038/Sj.Bjc.6605682  0.673
2010 Finger EC, Giaccia AJ. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Reviews. 29: 285-93. PMID 20393783 DOI: 10.1007/S10555-010-9224-5  0.39
2010 Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. Plos One. 5: e9633. PMID 20224789 DOI: 10.1371/Journal.Pone.0009633  0.516
2010 Turcotte S, Giaccia AJ. Targeting cancer cells through autophagy for anticancer therapy. Current Opinion in Cell Biology. 22: 246-51. PMID 20056398 DOI: 10.1016/J.Ceb.2009.12.007  0.396
2010 Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. Journal of Medicinal Chemistry. 53: 787-97. PMID 19994864 DOI: 10.1021/Jm901457W  0.759
2010 Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Molecular and Cellular Biology. 30: 344-53. PMID 19858293 DOI: 10.1128/Mcb.00444-09  0.706
2010 Lai EW, Chan DA, Hay MP, Giaccia AJ. Abstract 67: Selective cytotoxic targeting of von Hippel-Lindau-deficient renal cell carcinoma cells Cancer Research. 70: 67-67. DOI: 10.1158/1538-7445.Am10-67  0.679
2009 Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 139: 891-906. PMID 19931152 DOI: 10.1016/J.Cell.2009.10.027  0.326
2009 Cairns RA, Bennewith KL, Graves EE, Giaccia AJ, Chang DT, Denko NC. Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7170-4. PMID 19920111 DOI: 10.1158/1078-0432.Ccr-09-1676  0.377
2009 Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Molecular Cell. 35: 856-67. PMID 19782034 DOI: 10.1016/J.Molcel.2009.09.006  0.344
2009 Granchi C, Funaioli T, Erler JT, Giaccia AJ, Macchia M, Minutolo F. Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours. Chemmedchem. 4: 1590-4. PMID 19685543 DOI: 10.1002/Cmdc.200900247  0.354
2009 Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B, Cao H, Trotti A, Erler JT, Chung CH, Dicker A, Pajak TF, Giaccia AJ, Ang KK. Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 4281-6. PMID 19667273 DOI: 10.1200/Jco.2008.20.6003  0.302
2009 Xu Y, Hammerick KE, James AW, Carre AL, Leucht P, Giaccia AJ, Longaker MT. Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells. Tissue Engineering. Part A. 15: 3697-707. PMID 19505250 DOI: 10.1089/Ten.Tea.2009.0213  0.335
2009 Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 15: 527-38. PMID 19477431 DOI: 10.1016/J.Ccr.2009.04.010  0.779
2009 Rankin EB, Giaccia AJ, Hammond EM. Bringing H2AX into the angiogenesis family. Cancer Cell. 15: 459-61. PMID 19477424 DOI: 10.1016/J.Ccr.2009.05.004  0.65
2009 Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 113: 5568-74. PMID 19336759 DOI: 10.1182/Blood-2008-10-185686  0.68
2009 Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A, Giaccia AJ. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Research. 69: 775-84. PMID 19179545 DOI: 10.1158/0008-5472.Can-08-0987  0.552
2009 Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 15: 35-44. PMID 19111879 DOI: 10.1016/J.Ccr.2008.11.012  0.546
2009 Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. ATM activation and signaling under hypoxic conditions. Molecular and Cellular Biology. 29: 526-37. PMID 18981219 DOI: 10.1128/Mcb.01301-08  0.758
2009 Ko SH, Chan DA, Glotzbach JP, Giaccia AJ, Gurtner GC, Longaker MT. Stabilization of hypoxia-inducible factor-1 enhances proangiogenic potential of bone marrow–derived mesenchymal stem cells Journal of the American College of Surgeons. 209: S88. DOI: 10.1016/J.Jamcollsurg.2009.06.218  0.642
2008 Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Molecular Imaging. 7: 139-46. PMID 19123984  0.795
2008 Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ, Powell MB. Notch1 is an effector of Akt and hypoxia in melanoma development. The Journal of Clinical Investigation. 118: 3660-70. PMID 18924608 DOI: 10.1172/Jci36157  0.436
2008 Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Short hairpin RNA interference therapy for ischemic heart disease. Circulation. 118: S226-33. PMID 18824759 DOI: 10.1161/Circulationaha.107.760785  0.661
2008 Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle (Georgetown, Tex.). 7: 2987-90. PMID 18818511 DOI: 10.4161/Cc.7.19.6776  0.667
2008 Turcotte S, Sutphin PD, Giaccia AJ. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. Autophagy. 4: 944-6. PMID 18769110 DOI: 10.4161/Auto.6785  0.655
2008 Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 14: 90-102. PMID 18598947 DOI: 10.1016/J.Ccr.2008.06.004  0.778
2008 Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, Attardi LD. The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Molecular Cell. 30: 303-14. PMID 18471976 DOI: 10.1016/J.Molcel.2008.04.002  0.416
2008 Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Molecular Pharmacology. 74: 282-8. PMID 18424552 DOI: 10.1124/Mol.108.045690  0.697
2008 Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death and Differentiation. 15: 678-85. PMID 18259193 DOI: 10.1038/Cdd.2008.21  0.455
2008 Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Molecular Biology of the Cell. 19: 86-94. PMID 17942596 DOI: 10.1091/Mbc.E07-06-0612  0.682
2008 Giaccia AJ, Choi CYH, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS. Molecular imaging of hypoxia-inducible factor 1α and von Hippel-Lindau interaction in mice Molecular Imaging. 7: 139-146. DOI: 10.2310/7290.2008.00017  0.783
2007 Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation. 116: 2818-29. PMID 18040029 DOI: 10.1161/Circulationaha.107.715847  0.642
2007 Hammond EM, Kaufmann MR, Giaccia AJ. Oxygen sensing and the DNA-damage response. Current Opinion in Cell Biology. 19: 680-4. PMID 18023567 DOI: 10.1016/J.Ceb.2007.10.002  0.611
2007 Chan DA, Krieg AJ, Turcotte S, Giaccia AJ. HIF gene expression in cancer therapy. Methods in Enzymology. 435: 323-45. PMID 17998061 DOI: 10.1016/S0076-6879(07)35016-7  0.71
2007 Xu Y, Malladi P, Chiou M, Bekerman E, Giaccia AJ, Longaker MT. In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis. Tissue Engineering. 13: 2981-93. PMID 17916040 DOI: 10.1089/Ten.2007.0050  0.347
2007 Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Molecular Imaging. 6: 219-28. PMID 17711777 DOI: 10.2310/7290.2007.00017  0.771
2007 Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. International Journal of Radiation Oncology, Biology, Physics. 69: 167-75. PMID 17707270 DOI: 10.1016/J.Ijrobp.2007.01.071  0.522
2007 Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Research. 67: 5896-905. PMID 17575159 DOI: 10.1158/0008-5472.Can-07-0604  0.767
2007 Sutphin PD, Giaccia AJ, Chan DA. Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Developmental Cell. 12: 845-6. PMID 17543856 DOI: 10.1016/J.Devcel.2007.05.006  0.765
2007 Malladi P, Xu Y, Chiou M, Giaccia AJ, Longaker MT. Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells. Tissue Engineering. 13: 1159-71. PMID 17518738 DOI: 10.1089/Ten.2006.0265  0.374
2007 Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg HM, Johnson RS, Longaker MT, Giaccia AJ, Schipani E. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. The Journal of Cell Biology. 177: 451-64. PMID 17470636 DOI: 10.1083/Jcb.200612023  0.347
2007 Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Reviews. 26: 333-9. PMID 17458506 DOI: 10.1007/s10555-007-9063-1  0.659
2007 Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Molecular and Cellular Biology. 27: 912-25. PMID 17101781 DOI: 10.1128/Mcb.01223-06  0.692
2007 Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia Molecular Imaging. 6: 7290.2007.00017. DOI: 10.2310/7290.2007.00017  0.749
2007 Le Q, Erler JT, Giaccia A. M02-03: Tumor hypoxia and metastasis in non-small cell lung cancers Journal of Thoracic Oncology. 2: S154-S155. DOI: 10.1097/01.Jto.0000282931.32668.Ee  0.334
2007 Ham CM, Erler JT, Giaccia AJ, Longaker MT, Yang GP. Inhibition of an extracellular matrix protein increases survival in orthotopic nude mouse models Journal of the American College of Surgeons. 205: S95. DOI: 10.1016/J.Jamcollsurg.2007.06.237  0.402
2007 Lee P, Chan C, Hua A, Paulmurugan R, Chan D, Gambhir S, Le Q, Giaccia A. Noninvasive Monitoring of Ligand-Dependent VEGF Receptor-2 Dimerization With Split Firefly Luciferase International Journal of Radiation Oncology*Biology*Physics. 69: S96-S97. DOI: 10.1016/J.Ijrobp.2007.07.177  0.603
2006 Welford SM, Bedogni B, Gradin K, Poellinger L, Broome Powell M, Giaccia AJ. HIF1alpha delays premature senescence through the activation of MIF. Genes & Development. 20: 3366-71. PMID 17142669 DOI: 10.1101/Gad.1471106  0.396
2006 Petrik D, Lavori PW, Cao H, Zhu Y, Wong P, Christofferson E, Kaplan MJ, Pinto HA, Sutphin P, Koong AC, Giaccia AJ, Le QT. Plasma osteopontin is an independent prognostic marker for head and neck cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 5291-7. PMID 17114663 DOI: 10.1200/Jco.2006.06.8627  0.66
2006 Erler JT, Giaccia AJ. Lysyl oxidase mediates hypoxic control of metastasis. Cancer Research. 66: 10238-41. PMID 17079439 DOI: 10.1158/0008-5472.Can-06-3197  0.346
2006 Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Molecular and Cellular Biology. 26: 7030-45. PMID 16980608 DOI: 10.1128/Mcb.00322-06  0.638
2006 Hammond EM, Giaccia AJ. Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5007-9. PMID 16951213 DOI: 10.1158/1078-0432.Ccr-06-0613  0.633
2006 Freiberg RA, Krieg AJ, Giaccia AJ, Hammond EM. Checking in on hypoxia/reoxygenation. Cell Cycle (Georgetown, Tex.). 5: 1304-7. PMID 16760660 DOI: 10.4161/Cc.5.12.2811  0.803
2006 Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R, Nacalumi R, Höckel M, Le Q, Longaker M, Yang G, ... ... Giaccia A, et al. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Research. 66: 5816-27. PMID 16740721 DOI: 10.1158/0008-5472.Can-06-0081  0.805
2006 Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 440: 1222-6. PMID 16642001 DOI: 10.1038/Nature04695  0.413
2006 Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Genome-wide analysis of p53 under hypoxic conditions Molecular and Cellular Biology. 26: 3492-3504. PMID 16611991 DOI: 10.1128/Mcb.26.9.3492-3504.2006  0.666
2006 Le QT, Chen E, Salim A, Cao H, Kong CS, Whyte R, Donington J, Cannon W, Wakelee H, Tibshirani R, Mitchell JD, Richardson D, O'Byrne KJ, Koong AC, Giaccia AJ. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 1507-14. PMID 16533775 DOI: 10.1158/1078-0432.Ccr-05-2049  0.695
2006 Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Molecular and Cellular Biology. 26: 1598-609. PMID 16478982 DOI: 10.1128/Mcb.26.5.1598-1609.2006  0.813
2006 Kaper F, Dornhoefer N, Giaccia AJ. Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Research. 66: 1561-9. PMID 16452213 DOI: 10.1158/0008-5472.Can-05-3375  0.8
2006 Le QT, Cao H, Koong A, Giaccia A. Comment on: Osteopontin as toxic marker [1] Radiotherapy and Oncology. 78: 230. PMID 16442647 DOI: 10.1016/J.Radonc.2005.12.011  0.418
2006 Spear W, Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cellular Microbiology. 8: 339-52. PMID 16441443 DOI: 10.1111/J.1462-5822.2005.00628.X  0.684
2006 Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Børresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, et al. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. Plos Medicine. 3: e47. PMID 16417408 DOI: 10.1371/Journal.Pmed.0030047  0.423
2006 Malladi P, Xu Y, Chiou M, Giaccia AJ, Longaker MT. Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. American Journal of Physiology. Cell Physiology. 290: C1139-46. PMID 16291817 DOI: 10.1152/Ajpcell.00415.2005  0.328
2006 Hammond EM, Freiberg RA, Giaccia AJ. The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation. Cancer Letters. 238: 161-7. PMID 16085356 DOI: 10.1016/J.Canlet.2005.06.029  0.803
2006 Lee YK, Shanafelt T, Chan D, Giaccia A, Mukhopadhyay D, Taccioli C, Calin G, Croce C, Kay NE. Elevated HIF-1α Levels in CLL B Cells May Explain Their Autocrine VEGF Secretion. Blood. 108: 583-583. DOI: 10.1182/Blood.V108.11.583.583  0.663
2006 Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R, Höckel M, Le Q, Longaker M, Yang G, Koong A, ... Giaccia A, et al. Erratum: Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis (Cancer Research (June 1, 2006) 66 (5816-5827)) Cancer Research. 66. DOI: 10.1158/0008-5472.Can-66-15-Cor  0.786
2006 Erler J, Dornhoefer N, Le Q, Kong C, Chi J, Nicolau M, Jeffrey S, Giaccia A. 12 LOX is essential for hypoxia-induced metastasis Radiotherapy and Oncology. 78: S5. DOI: 10.1016/S0167-8140(06)80506-2  0.369
2006 Erler J, Le Q, Giaccia AJ. 88: Lysyl Oxidase Is Essential for Hypoxia-Induced Metastasis International Journal of Radiation Oncology Biology Physics. 66. DOI: 10.1016/J.Ijrobp.2006.07.118  0.371
2006 Choi C, Paulmurugan R, Chan D, Sutphin P, Le Q, Koong A, Gambhir S, Giaccia A. 83 International Journal of Radiation Oncology*Biology*Physics. 66: S48-S49. DOI: 10.1016/J.Ijrobp.2006.07.113  0.76
2005 Koong A, Kong C, Zhao S, Richardson D, O'Byrne K, Pinto H, Denko NC, Giaccia AJ, Le QT. Expression and prognostic significance of tissue hypoxia markers in head and neck squamous cell carcinomas (HNSCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 5559. PMID 27945317 DOI: 10.1200/Jco.2005.23.16_Suppl.5559  0.544
2005 Le QT, Koong AC, Pinto HA, Giaccia AJ, Kong C. Expression of p16 as a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 5520. PMID 27945247 DOI: 10.1200/Jco.2005.23.16_Suppl.5520  0.5
2005 Petrik DW, Cao H, Zhu Y, Wong P, Sutphin P, Giaccia AJ, Koong AA, Le QT. An expanded study of the relationship between osteopontin, tumor pO2 and prognosis in head and neck squamous cell carcinomas. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 5521. PMID 27945243 DOI: 10.1200/Jco.2005.23.16_Suppl.5521  0.636
2005 Spong SM, Dornhofer N, Wong C, Lomongsod E, Salim A, Le Q, Koong A, Klaus S, Giaccia A. Inhibition of pancreatic tumor growth and progression by a human monoclonal antibody specific for connective tissue growth factor. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 4150. PMID 27944587 DOI: 10.1200/Jco.2005.23.16_Suppl.4150  0.542
2005 Bedogni B, Welford SM, Cassarino DS, Nickoloff BJ, Giaccia AJ, Powell MB. The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Cancer Cell. 8: 443-54. PMID 16338658 DOI: 10.1016/J.Ccr.2005.11.005  0.357
2005 Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, Zhao S, Kong C, Richardson D, O'Byrne KJ, Giaccia AJ, Koong AC. Galectin-1: a link between tumor hypoxia and tumor immune privilege. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 8932-41. PMID 16219933 DOI: 10.1200/Jco.2005.02.0206  0.709
2005 Chan DA, Sutphin PD, Yen SE, Giaccia AJ. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Molecular and Cellular Biology. 25: 6415-26. PMID 16024780 DOI: 10.1128/Mcb.25.15.6415-6426.2005  0.767
2005 Nelson DW, Cao H, Zhu Y, Sunar-Reeder B, Choi CY, Faix JD, Brown JM, Koong AC, Giaccia AJ, Le QT. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. Cancer Research. 65: 6151-8. PMID 16024616 DOI: 10.1158/0008-5472.Can-04-2602  0.573
2005 Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le QT. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene. 24: 6555-63. PMID 16007184 DOI: 10.1038/Sj.Onc.1208800  0.747
2005 Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochemical and Biophysical Research Communications. 331: 718-25. PMID 15865928 DOI: 10.1016/J.Bbrc.2005.03.154  0.66
2005 Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Research. 65: 3171-8. PMID 15833847 DOI: 10.1158/0008-5472.Can-04-3395  0.802
2005 Yun Z, Lin Q, Giaccia AJ. Adaptive myogenesis under hypoxia. Molecular and Cellular Biology. 25: 3040-55. PMID 15798192 DOI: 10.1128/Mcb.25.8.3040-3055.2005  0.337
2005 Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Molecular Cell. 17: 503-12. PMID 15721254 DOI: 10.1016/J.Molcel.2005.01.011  0.675
2005 Johnson TM, Hammond EM, Giaccia A, Attardi LD. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality Nature Genetics. 37: 145-152. PMID 15654339 DOI: 10.1038/Ng1498  0.657
2005 Erler J, Jeffrey S, Giaccia A. Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression Breast Cancer Research. 7: 1-1. DOI: 10.1186/Bcr1186  0.325
2005 Lee YK, Strege AK, Bone ND, Wellik LE, Chan DA, Giaccia AJ, Mukhopadhyay D, Kay NE. Hypoxia Inducible Factor-1α Is over Expressed in CLL B Cells Because of an Impaired Proteasome Pathway Associated with Defective Interaction with von Hippel-Landau Protein. Blood. 106: 2115-2115. DOI: 10.1182/Blood.V106.11.2115.2115  0.67
2005 Malladi P, Xu Y, Giaccia A, Longaker MT. The effect of pre-exposure to hypoxia on in vitro chondrogenesis of adipose-derived mesenchymal cells (AMCs) Journal of the American College of Surgeons. 201: S49. DOI: 10.1016/J.Jamcollsurg.2005.06.106  0.309
2005 Choi C, Paulmurugan R, Ghambir S, Koong A, Le Q, Giaccia A. Molecular Imaging of HIF-1α and pVHL Interaction In Vivo: The Study of Structure/Function Relationship Guiding HIF-1α and pVHL International Journal of Radiation Oncology*Biology*Physics. 63: S133-S134. DOI: 10.1016/J.Ijrobp.2005.07.227  0.442
2004 Chen Y, Shi G, Xia W, Kong C, Zhao S, Gaw AF, Chen EY, Yang GP, Giaccia AJ, Le QT, Koong AC. Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Research. 64: 7302-10. PMID 15492250 DOI: 10.1158/0008-5472.Can-04-0899  0.744
2004 Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research. 64: 6556-62. PMID 15374968 DOI: 10.1158/0008-5472.Can-04-1520  0.686
2004 Giaccia AJ, Simon MC, Johnson R. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes & Development. 18: 2183-94. PMID 15371333 DOI: 10.1101/Gad.1243304  0.335
2004 Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouysségur J, Yaniv M, Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress Cell. 118: 781-794. PMID 15369676 DOI: 10.1016/J.Cell.2004.08.025  0.716
2004 Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Research. 64: 5943-7. PMID 15342372 DOI: 10.1158/0008-5472.Can-04-1606  0.747
2004 Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, Tibshirani R, Giaccia AJ, Giudice LC. Developmental response to hypoxia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1348-65. PMID 15333578 DOI: 10.1096/Fj.03-1377Com  0.332
2004 Hammond EM, Giaccia AJ. The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. Dna Repair. 3: 1117-22. PMID 15279800 DOI: 10.1016/J.Dnarep.2004.03.035  0.674
2004 Soltys SG, Le QT, Shi G, Tibshirani R, Giaccia AJ, Koong AC. The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 4806-12. PMID 15269156 DOI: 10.1158/1078-0432.Ccr-03-0469  0.446
2004 Salim A, Nacamuli RP, Morgan EF, Giaccia AJ, Longaker MT. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. The Journal of Biological Chemistry. 279: 40007-16. PMID 15263007 DOI: 10.1074/Jbc.M403715200  0.365
2004 Leo C, Giaccia AJ, Denko NC. The hypoxic tumor microenvironment and gene expression. Seminars in Radiation Oncology. 14: 207-14. PMID 15254863 DOI: 10.1016/J.Semradonc.2004.04.007  0.391
2004 Le QT, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis Cancer and Metastasis Reviews. 23: 293-310. PMID 15197330 DOI: 10.1023/B:Canc.0000031768.89246.D7  0.45
2004 Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (Cambridge, England). 131: 2497-508. PMID 15128677 DOI: 10.1242/Dev.01138  0.681
2004 Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611  0.342
2004 Bemis L, Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes & Development. 18: 739-44. PMID 15082527 DOI: 10.1101/Gad.1180104  0.788
2004 Swiersz LM, Giaccia AJ, Yun Z. Oxygen-dependent regulation of adipogenesis. Methods in Enzymology. 381: 387-95. PMID 15063688 DOI: 10.1016/S0076-6879(04)81026-7  0.348
2004 Bedogni B, O'Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB. Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice Cancer Research. 64: 2552-2560. PMID 15059911 DOI: 10.1158/0008-5472.Can-03-3327  0.341
2004 Sutphin PD, Chan DA, Giaccia AJ. Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle (Georgetown, Tex.). 3: 160-3. PMID 14712081  0.78
2004 Sutphin PD, Chan DA, Giaccia AJ. Dead Cells Don’t Form Tumors: HIF-Dependent Cytotoxins Cell Cycle. 3: 160-163. DOI: 10.4161/Cc.3.2.617  0.793
2004 Romero L, Cao H, Hammond E, Giaccia A, Le Q, Koong A. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth International Journal of Radiation Oncology*Biology*Physics. 60: S192-S193. DOI: 10.1016/j.ijrobp.2004.06.130  0.439
2004 Le Q, Shi G, Nelson D, Patel D, Zhao S, Giaccia A, Kong C, Koong A. Identification of galectin-1 as a novel hypoxia-regulated protein via proteomic approaches International Journal of Radiation Oncology*Biology*Physics. 60: S192. DOI: 10.1016/J.Ijrobp.2004.06.129  0.483
2003 Hammond EM, Green SL, Giaccia AJ. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutation Research. 532: 205-13. PMID 14643437 DOI: 10.1016/J.Mrfmmm.2003.08.017  0.76
2003 Giaccia A, Siim BG, Johnson RS. HIF-1 as a target for drug development. Nature Reviews. Drug Discovery. 2: 803-11. PMID 14526383 DOI: 10.1038/Nrd1199  0.355
2003 Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 22: 5907-14. PMID 12947397 DOI: 10.1038/Sj.Onc.1206703  0.673
2003 Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Molecular and Cellular Biology. 23: 4959-71. PMID 12832481 DOI: 10.1128/Mcb.23.14.4959-4971.2003  0.363
2003 Yun Z, Giaccia AJ. Tumor deprivation of oxygen and tumor suppressor gene function. Methods in Molecular Biology (Clifton, N.J.). 223: 485-504. PMID 12777746 DOI: 10.1385/1-59259-329-1:485  0.356
2003 Le QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 59-67. PMID 12538452  0.676
2003 Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. The Journal of Biological Chemistry. 278: 12207-13. PMID 12519769 DOI: 10.1074/Jbc.M212360200  0.667
2003 Soltys S, Shi G, Tibshirani R, Giaccia A, Koong A, Le Q. The use of plasma SELDI-TOF MS proteomic patterns for detection of head and neck squamous cell cancers (HNSCC) International Journal of Radiation Oncology*Biology*Physics. 57: S202. DOI: 10.1016/S0360-3016(03)01006-X  0.453
2003 Salim A, Nacamuli R, Giaccia A, Longaker M. Changes in oxygen tension modulate osteoblast gene expression and long-term differentiation Journal of Surgical Research. 114: 309. DOI: 10.1016/J.Jss.2003.08.127  0.326
2002 Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Molecular and Cellular Biology. 22: 7004-14. PMID 12242281 DOI: 10.1128/Mcb.22.20.7004-7014.2002  0.791
2002 Maecker HL, Yun Z, Maecker HT, Giaccia AJ. Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Cancer Cell. 2: 139-48. PMID 12204534 DOI: 10.1016/S1535-6108(02)00095-8  0.788
2002 Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. The Journal of Biological Chemistry. 277: 40112-7. PMID 12186875 DOI: 10.1074/Jbc.M206922200  0.763
2002 Hammond EM, Giaccia AJ. Antiangiogenic therapy and p53. Science (New York, N.Y.). 297: 471; discussion 471. PMID 12142499 DOI: 10.1126/Science.297.5581.471A  0.578
2002 Lluria-Prevatt M, Morreale J, Gregus J, Alberts DS, Kaper F, Giaccia A, Powell MB. Effects of perillyl alcohol on melanoma in the TPras mouse model. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 11: 573-9. PMID 12050099  0.741
2002 Shibata T, Giaccia AJ, Brown JM. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia (New York, N.Y.). 4: 40-8. PMID 11922390 DOI: 10.1038/Sj.Neo.7900189  0.439
2002 Liu SC, Minton NP, Giaccia AJ, Brown JM. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Therapy. 9: 291-296. PMID 11896468 DOI: 10.1038/Sj.Gt.3301659  0.342
2002 Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Developmental Cell. 2: 331-41. PMID 11879638 DOI: 10.1016/S1534-5807(02)00131-4  0.79
2002 Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Molecular and Cellular Biology. 22: 1834-43. PMID 11865061 DOI: 10.1128/Mcb.22.6.1834-1843.2002  0.679
2002 Alarcon RM, Denko NC, Giaccia AJ. Genetic determinants that influence hypoxia-induced apoptosis. Novartis Foundation Symposium. 240: 115-28; discussion 1. PMID 11727925 DOI: 10.1002/0470868716.Ch8  0.344
2002 Choi C, Fontana L, Sutphin P, Hammond E, Denko N, Giaccia A, Koong A, Le Q. Adipophilin: a novel hypoxia regulated gene International Journal of Radiation Oncology*Biology*Physics. 54: 121. DOI: 10.1016/S0360-3016(02)03265-0  0.689
2001 Chen EY, Mazure NM, Cooper JA, Giaccia AJ. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Research. 61: 2429-33. PMID 11289110  0.598
2001 Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Molecular and Cellular Biology. 21: 1297-310. PMID 11158315 DOI: 10.1128/Mcb.21.4.1297-1310.2001  0.658
2001 Green SL, Freiberg RA, Giaccia AJ. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Molecular and Cellular Biology. 21: 1196-206. PMID 11158306 DOI: 10.1128/Mcb.21.4.1196-1206.2001  0.8
2001 Sutphin PD, Raychaudhuri S, Denko NC, Altman RB, Giaccia AJ. Application of supervised machine learning to identify genes associated with the hypoxia response Nature Genetics. 27: 90-90. DOI: 10.1038/87320  0.586
2001 Le Q, Sutphin P, Raychaudhuri S, Terris D, Lin H, Koong A, Chen U, Tibshirani R, Denko N, Giaccia A. Osteopontin - a new serum marker for tumor hypoxia International Journal of Radiation Oncology*Biology*Physics. 51: 80. DOI: 10.1016/S0360-3016(01)01971-X  0.687
2000 Fox ME, Lemmon MJ, Giaccia AJ, Minton NP, Brown JM. Genetically modified clostridium for gene therapy of tumors. Methods in Molecular Medicine. 35: 413-8. PMID 21390820 DOI: 10.1385/1-59259-086-1:413  0.38
2000 Sugawara J, Tazuke SI, Suen LF, Powell DR, Kaper F, Giaccia AJ, Giudice LC. Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. The Journal of Clinical Endocrinology and Metabolism. 85: 3821-7. PMID 11061545 DOI: 10.1210/Jcem.85.10.6866  0.761
2000 Maecker HL, Koumenis C, Giaccia AJ. p53 promotes selection for Fas-mediated apoptotic resistance. Cancer Research. 60: 4638-44. PMID 10969818  0.786
2000 Sugawara J, Suh DS, Faessen GH, Suen LF, Shibata T, Kaper F, Giaccia AJ, Giudice LC. Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. The Journal of Clinical Endocrinology and Metabolism. 85: 2714-21. PMID 10946870 DOI: 10.1210/Jcem.85.8.6709  0.779
2000 Laderoute KR, Alarcon RM, Brody MD, Calaoagan JM, Chen EY, Knapp AM, Yun Z, Denko NC, Giaccia AJ. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 2941-50. PMID 10914744  0.637
2000 Denko NC, Green SL, Edwards D, Giaccia AJ. p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Experimental Cell Research. 258: 82-91. PMID 10912790 DOI: 10.1006/Excr.2000.4928  0.664
2000 Shibata T, Giaccia AJ, Brown JM. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Therapy. 7: 493-8. PMID 10757022 DOI: 10.1038/Sj.Gt.3301124  0.404
2000 Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes & Development. 14: 391-6. PMID 10691731 DOI: 10.1101/Gad.14.4.391  0.817
2000 Zundel W, Swiersz LM, Giaccia A. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Molecular and Cellular Biology. 20: 1507-14. PMID 10669728 DOI: 10.1128/Mcb.20.5.1507-1514.2000  0.759
2000 Wouters BG, Denko NC, Giaccia AJ, Brown JM. A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy. Oncogene. 18: 6540-5. PMID 10597257 DOI: 10.1038/Sj.Onc.1203053  0.337
2000 Swiersz L, Maecker H, Giaccia A. Effects of Dioxin on Cell Cycle Progression in Dioxin-Responsive Endometrial Cells Which Show Induction of Cellular Repressor of E1A-Stimulated Genes Fertility and Sterility. 74: S186. DOI: 10.1016/S0015-0282(00)01264-4  0.333
1999 Chen EY, Fujinaga M, Giaccia AJ. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology. 60: 215-25. PMID 10508975 DOI: 10.1002/(Sici)1096-9926(199910)60:4<215::Aid-Tera6>3.0.Co;2-2  0.612
1999 Popovici RM, Irwin JC, Giaccia AJ, Giudice LC. Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. The Journal of Clinical Endocrinology and Metabolism. 84: 2245-8. PMID 10372740 DOI: 10.1210/Jcem.84.6.5886  0.341
1999 Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ, Stork PJ. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. The Journal of Biological Chemistry. 274: 12890-7. PMID 10212278 DOI: 10.1074/Jbc.274.18.12890  0.401
1999 Soengas MS, Alarcón RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW, Lowe SW. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (New York, N.Y.). 284: 156-9. PMID 10102818 DOI: 10.1126/Science.284.5411.156  0.386
1999 Koong A, Denko N, Schindler C, Le Q, Terris D, Ibrahim H, Goffinet D, Giaccia A. 104 candidate genes for the hypoxic tumor phenotype International Journal of Radiation Oncology*Biology*Physics. 45: 201. DOI: 10.1016/S0360-3016(99)90122-0  0.512
1998 Rupnow BA, Alarcon RM, Giaccia AJ, Knox SJ. p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts. Cell Death & Differentiation. 5: 141-147. PMID 10200458 DOI: 10.1038/Sj.Cdd.4400328  0.314
1998 Giaccia AJ, Kastan MB. The complexity of p53 modulation: emerging patterns from divergent signals. Genes & Development. 12: 2973-83. PMID 9765199 DOI: 10.1101/Gad.12.19.2973  0.317
1998 Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, Irwin JC, Powell DR, Giaccia AJ, Giudice LC. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proceedings of the National Academy of Sciences of the United States of America. 95: 10188-93. PMID 9707622 DOI: 10.1073/Pnas.95.17.10188  0.402
1998 Green SL, Giaccia AJ. Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy. The Cancer Journal From Scientific American. 4: 218-23. PMID 9689978  0.622
1998 Zundel W, Giaccia A. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes & Development. 12: 1941-6. PMID 9649498 DOI: 10.1101/Gad.12.13.1941  0.76
1998 Buzzard KA, Giaccia AJ, Killender M, Anderson RL. Heat shock protein 72 modulates pathways of stress-induced apoptosis. The Journal of Biological Chemistry. 273: 17147-53. PMID 9642282 DOI: 10.1074/Jbc.273.27.17147  0.344
1998 Giaccia AJ, Brown JM, Wouters B, Denko N, Koumenis C. Cancer therapy and tumor physiology. Science (New York, N.Y.). 279: 12-3. PMID 9441397 DOI: 10.1126/Science.279.5347.10E  0.395
1998 Tazuke SI, Mazure N, Motani A, Powell DR, Giaccia A, Giudice LC. Hypoxia response element (hre) in the insulin-like growth factor binding protein-i (igfbp-1) gene is functional: Potential relevance to hypoxia Journal of the Society For Gynecologic Investigation. 5. DOI: 10.1016/S1071-5576(97)86181-3  0.306
1998 Marquez SD, Derr J, Koumenis C, Giaccia AJ. Bax protein is not involved in hypoxia-induced apoptosis International Journal of Radiation Oncology*Biology*Physics. 42: 136. DOI: 10.1016/S0360-3016(98)80125-9  0.327
1998 Giaccia AJ. Radiation and hypoxia induced changes in gene expression: Diagnostic and therapeutic uses in radiotherapy International Journal of Radiation Oncology*Biology*Physics. 42: 117. DOI: 10.1016/S0360-3016(98)80087-4  0.315
1997 Koumenis C, Giaccia A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Molecular and Cellular Biology. 17: 7306-16. PMID 9372962 DOI: 10.1128/Mcb.17.12.7306  0.385
1997 Mazure NM, Chen EY, Laderoute KR, Giaccia AJ. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 90: 3322-31. PMID 9345014 DOI: 10.1182/Blood.V90.9.3322  0.656
1997 Lemmon MJ, van Zijl P, Fox ME, Mauchline ML, Giaccia AJ, Minton NP, Brown JM. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Therapy. 4: 791-6. PMID 9338007 DOI: 10.1038/Sj.Gt.3300468  0.31
1997 Giaccia A, Alarcon R, Brody M, Calaoagan J, Mazure N, Sutherland R, Laderoute K. The influence of the tumor microenvironment on malignant progression European Journal of Cancer. 33: S219. DOI: 10.1016/S0959-8049(97)85748-6  0.329
1997 Kim CY, Tsai MH, Osmanian C, Calkins DP, Graeber TG, Greenspan DL, Kennedy AS, Rinker LH, Varia MA, DiPaolo JA, Peehl DM, Raleigh JA, Giaccia AJ. 142 The role of hypoxia, p53, and apoptosis in human cervical carcinoma pathogenesis International Journal of Radiation Oncology*Biology*Physics. 39: 206. DOI: 10.1016/S0360-3016(97)80701-8  0.55
1997 Rupnow BA, Murtha AD, Alarcon RM, Giaccia AJ, Knox SJ. 89 Apoptotic potential and cell sensitivity to fractionated radiotherapy International Journal of Radiation Oncology*Biology*Physics. 39: 179. DOI: 10.1016/S0360-3016(97)80646-3  0.314
1996 Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P, Allalunis-Turner J, Chen DJ, Fishel R, Giaccia AJ, Brown JM, Kirchgessner CU. The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proceedings of the National Academy of Sciences of the United States of America. 93: 13825-30. PMID 8943020 DOI: 10.1073/Pnas.93.24.13825  0.618
1996 Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Research. 56: 3436-40. PMID 8758908  0.602
1996 Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379: 88-91. PMID 8538748 DOI: 10.1038/379088A0  0.616
1996 Giaccia AJ. Hypoxic stress proteins: Survival of the fittest Seminars in Radiation Oncology. 6: 46-58. DOI: 10.1016/S1053-4296(96)80035-X  0.472
1996 Kim CY, Tsai M, Graeber TG, Peehl DM, Giaccia AJ. 2210 HPV E6 and E7 in hypoxia mediated tumorigenesis in cervical epithelial cells International Journal of Radiation Oncology*Biology*Physics. 36: 379. DOI: 10.1016/S0360-3016(97)85781-1  0.517
1996 Giaccia AJ. 301C Molecular biology III — Oncogenes and tumor suppressor genes International Journal of Radiation Oncology*Biology*Physics. 36: 143. DOI: 10.1016/S0360-3016(97)85309-6  0.314
1994 Denko NC, Giaccia AJ, Stringer JR, Stambrook PJ. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 91: 5124-8. PMID 8197195 DOI: 10.1073/Pnas.91.11.5124  0.325
1994 Koong AC, Chen EY, Kim CY, Giaccia AJ. Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells. International Journal of Radiation Oncology, Biology, Physics. 29: 259-65. PMID 8195017 DOI: 10.1016/0360-3016(94)90272-0  0.703
1994 Koong AC, Auger EA, Chen EY, Giaccia AJ. The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors. Radiation Research. 138: S60-3. PMID 8146329 DOI: 10.2307/3578763  0.709
1994 Koong AC, Chen EY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Research. 54: 1425-30. PMID 8137243  0.566
1994 Koong AC, Chen EY, Lee AS, Brown JM, Giaccia AJ. Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. International Journal of Radiation Oncology, Biology, Physics. 28: 661-6. PMID 8113109 DOI: 10.1016/0360-3016(94)90191-0  0.689
1994 Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Giaccia AJ. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Molecular and Cellular Biology. 14: 6264-77. PMID 8065358 DOI: 10.1128/mcb.14.9.6264-6277.1994  0.611
1994 Mivechi NF, Koong AC, Giaccia AJ, Hahn GM. Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 10: 371-9. PMID 7930803 DOI: 10.3109/02656739409010281  0.477
1994 Saad AH, Kuo SS, Koong AC, Hahn GM, Giaccia AJ. Modulation of potassium channels by protein tyrosine kinase inhibitors. Journal of Cellular Physiology. 161: 142-8. PMID 7929599 DOI: 10.1002/Jcp.1041610117  0.481
1994 Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ. Hypoxic Activation of Nuclear Factor-kB Is Mediated by a Ras and Raf Signaling Pathway and Does Not Involve MAP Kinase (ERK1 or ERK2) Cancer Research. 54: 5273-5279. PMID 7923153  0.58
1994 Brown JM, Giaccia AJ. Tumour hypoxia: the picture has changed in the 1990s. International Journal of Radiation Biology. 65: 95-102. PMID 7905916 DOI: 10.1080/09553009414550131  0.373
1994 Graeber TG, Monica KA, Fornace AJ, Giaccia AJ. Low oxygen conditions activate a G1/S-phase checkpoint independent of p53 status International Journal of Radiation Oncology*Biology*Physics. 30: 196. DOI: 10.1016/0360-3016(94)90701-3  0.544
1994 Koong AC, Chen EY, Denko NC, Stambrook P, Giaccia AJ. Defining the pathway which leads to NF-κB activation by low oxygen conditions International Journal of Radiation Oncology*Biology*Physics. 30: 161. DOI: 10.1016/0360-3016(94)90640-8  0.681
1993 Kuo SS, Saad AH, Koong AC, Hahn GM, Giaccia AJ. Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 908-12. PMID 8430104 DOI: 10.1073/Pnas.90.3.908  0.499
1993 Koong AC, Giaccia AJ, Hahn GM, Saad AH. Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549. Journal of Cellular Physiology. 156: 341-7. PMID 8344990 DOI: 10.1002/Jcp.1041560217  0.476
1992 Giaccia AJ, Auger EA, Koong A, Terris DJ, Minchinton AI, Hahn GM, Brown JM. Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. International Journal of Radiation Oncology, Biology, Physics. 23: 891-7. PMID 1618682 DOI: 10.1016/0360-3016(92)90667-7  0.58
1992 Cholon A, Giaccia AJ, Lewis AD, Hickson I, Brown JM. What role do glutathione S-transferases play in the cellular response to ionizing radiation? International Journal of Radiation Oncology, Biology, Physics. 22: 759-63. PMID 1544849 DOI: 10.1016/0360-3016(92)90519-N  0.327
1992 Giaccia AJ, Biedermann KA, Tosto LM, Minchinton AI, Kovacs MS, Brown JM. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233. International Journal of Radiation Oncology, Biology, Physics. 22: 681-4. PMID 1544836 DOI: 10.1016/0360-3016(92)90502-9  0.341
1992 Giaccia AJ, Schwartz J, Shieh J, Brown JM. The use of asymmetric-field inversion gel electrophoresis to predict tumor cell radiosensitivity. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 24: 231-8. PMID 1410578 DOI: 10.1016/0167-8140(92)90229-N  0.394
1992 Kim CY, Giaccia AJ, Strulovici B, Brown JM. Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. British Journal of Cancer. 66: 844-9. PMID 1329908 DOI: 10.1038/Bjc.1992.371  0.354
1992 Koong A, Auger E, Brown J, Giaccia A. Development of molecular strategies to exploit tumor hypoxia based on hypoxia regulated gene induction International Journal of Radiation Oncology*Biology*Physics. 24: 163. DOI: 10.1016/0360-3016(92)90200-2  0.554
1991 Biedermann KA, Sun JR, Giaccia AJ, Tosto LM, Brown JM. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America. 88: 1394-7. PMID 1996340 DOI: 10.1073/Pnas.88.4.1394  0.316
1991 Giaccia A, Auger E, Hahn G, Brown J. Detection of cellular hypoxia by activation of the heat shock transcription factor (HSF): A method for hypoxic cell “marking” in vivo International Journal of Radiation Oncology*Biology*Physics. 21: 186-187. DOI: 10.1016/0360-3016(91)90563-J  0.33
1990 Giaccia AJ, MacLaren RA, Denko N, Nicolaou D, Stamato TD. Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant. Mutation Research. 236: 67-76. PMID 2164147 DOI: 10.1016/0921-8777(90)90034-3  0.694
1989 Giaccia AJ, Richardson E, Denko N, Stamato TD. Genetic analysis of XR-1 mutation in hamster and human hybrids. Somatic Cell and Molecular Genetics. 15: 71-7. PMID 2916163 DOI: 10.1007/Bf01534671  0.7
1989 Denko N, Giaccia A, Peters B, Stamato TD. An asymmetric field inversion gel electrophoresis method for the separation of large DNA molecules. Analytical Biochemistry. 178: 172-6. PMID 2729570 DOI: 10.1016/0003-2697(89)90375-8  0.67
1989 Stamato TD, Richardson E, Ianacone J, MacLaren RA, Denko N, Giaccia A. Isolation and characterization of glucose-6-phosphate dehydrogenase-deficient Chinese hamster cells derived from pure mutant colonies. Mutagenesis. 4: 259-64. PMID 2674604 DOI: 10.1093/Mutage/4.4.259  0.697
1988 Stamato TD, Dipatri A, Giaccia A. Cell-Cycle-Dependent Repair of Potentially Lethal Damage in the XR-1 γ-Ray-Sensitive Chinese Hamster Ovary Cell Radiation Research. 115: 325. DOI: 10.2307/3577168  0.708
1987 Stamato T, Weinstein R, Peters B, Hu J, Doherty B, Giaccia A. Delayed mutation in Chinese hamster cells. Somatic Cell and Molecular Genetics. 13: 57-65. PMID 3468633 DOI: 10.1007/Bf02422299  0.699
1985 Giaccia A, Weinstein R, Hu J, Stamato TD. Cell cycle-dependent repair of double-strand DNA breaks in a gamma-ray-sensitive Chinese hamster cell. Somatic Cell and Molecular Genetics. 11: 485-91. PMID 3862244 DOI: 10.1007/Bf01534842  0.707
1984 Stamato TD, Weinstein R, Giaccia A. Timing of mutation-fixation events in ethyl methane sulfonate-treated Chinese hamster cells. Somatic Cell and Molecular Genetics. 10: 429-34. PMID 6589795 DOI: 10.1007/Bf01535639  0.694
1983 Stamato TD, Weinstein R, Giaccia A, Mackenzie L. Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell. Somatic Cell Genetics. 9: 165-73. PMID 6836453 DOI: 10.1007/Bf01543175  0.706
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