Floyd H. Chilton - Publications

Affiliations: 
Wake Forest University School of Medicine, Winston-Salem, NC, United States 
Area:
Molecular Biology, Cell Biology, Oncology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sergeant S, Keith BA, Seeds MC, Legins JA, Young CB, Vitolins MZ, Chilton FH. Impact of gene variation and dietary fatty acid exposure on biochemical and anthropomorphic phenotypes in a Hispanic/Latino cohort. Frontiers in Nutrition. 10: 1111624. PMID 37215219 DOI: 10.3389/fnut.2023.1111624  0.387
2022 Raikes AC, Hernandez GD, Mullins VA, Wang Y, Lopez C, Killgore WDS, Chilton FH, Brinton RD. Effects of docosahexaenoic acid and eicosapentaoic acid supplementation on white matter integrity after repetitive sub-concussive head impacts during American football: Exploratory neuroimaging findings from a pilot RCT. Frontiers in Neurology. 13: 891531. PMID 36188406 DOI: 10.3389/fneur.2022.891531  0.308
2022 Chilton FH, Manichaikul A, Yang C, O'Connor TD, Johnstone LM, Blomquist S, Schembre SM, Sergeant S, Zec M, Tsai MY, Rich SS, Bridgewater SJ, Mathias RA, Hallmark B. Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and Genetic Variation. Frontiers in Nutrition. 8: 808054. PMID 35211495 DOI: 10.3389/fnut.2021.808054  0.409
2021 Fernandez ML, Blomquist SA, Hallmark B, Chilton FH. Omega-3 Supplementation and Heart Disease: A Population-Based Diet by Gene Analysis of Clinical Trial Outcomes. Nutrients. 13. PMID 34201625 DOI: 10.3390/nu13072154  0.324
2020 Poole LB, Parsonage D, Sergeant S, Miller LR, Lee J, Furdui CM, Chilton FH. Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids. Biotechnology For Biofuels. 13: 83. PMID 32399061 DOI: 10.1186/S13068-020-01719-7  0.439
2020 Waits CMK, Bower A, Simms KN, Feldman BC, Kim N, Sergeant S, Chilton FH, VandeVord PJ, Langefeld C, Rahbar E. A pilot study assessing the impact of rs174537 on circulating PUFAs and the inflammatory response in TBI patients. Journal of Neurotrauma. PMID 32253986 DOI: 10.1089/Neu.2019.6734  0.385
2020 Sergeant S, Hallmark B, Mathias RA, Mustin TL, Ivester P, Bohannon ML, Ruczinski I, Johnstone L, Seeds MC, Chilton FH. Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils. The American Journal of Clinical Nutrition. PMID 32167131 DOI: 10.1093/Ajcn/Nqaa023  0.481
2020 Blomquist S, Coletta D, Mandarino LJ, Hallmark B, Yang C, Rich S, Manichaikul AW, Chilton F. Abstract MP67: Fatty Acid Desaturase Gene-induced Omega-3 Deficiency In Amerindian-Ancestry Hispanic Populations Circulation. 141. DOI: 10.1161/Circ.141.Suppl_1.Mp67  0.44
2020 Blomquist S, Coletta D, Mandarino LJ, Hallmark B, Yang C, Rich S, Manichaikul AW, Chilton F. Fatty Acid Desaturase Gene‐Induced Omega‐3 Deficiency in Amerindian‐Ancestry Hispanic Populations The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06389  0.43
2019 Harris DN, Ruczinski I, Yanek LR, Becker LC, Becker DM, Guio H, Cui T, Chilton FH, Mathias RA, O'Connor TD. Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World. Genome Biology and Evolution. PMID 30942856 DOI: 10.1093/Gbe/Evz071  0.439
2018 Rahbar E, Waits CMK, Kirby EH, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FH. Allele-specific methylation in the genomic region in DNA from human saliva, CD4+ cells, and total leukocytes. Clinical Epigenetics. 10: 46. PMID 29636834 DOI: 10.1186/S13148-018-0480-5  0.326
2018 Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH. Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. Plos One. 13: e0194610. PMID 29590160 DOI: 10.1371/Journal.Pone.0194610  0.38
2018 Dutta R, Rahbar E, Cui T, Seeds M, Sergeant S, Mohler J, Fontham E, Smith G, Langefeld C, Bensen J, Chilton F. Mp70-18 The Role Of Polyunsaturated Fatty Acid Metabolism On Prostate Cancer Aggressiveness: An Analysis Of The North Carolina-Louisiana Prostate Cancer Project (Pcap) The Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.2262  0.302
2017 Wang M, Chen H, Ailati A, Chen W, Chilton FH, Todd Lowther W, Chen YQ. Substrate specificity and membrane topologies of the iron-containing ω3 and ω6 desaturases from Mortierella alpina. Applied Microbiology and Biotechnology. PMID 29082420 DOI: 10.1007/S00253-017-8585-X  0.476
2017 Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC. Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. Nutrients. 9. PMID 29068398 DOI: 10.3390/Nu9111165  0.529
2016 Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH. Impact of genetic and epigenetic variations within the FADS cluster on the composition and metabolism of polyunsaturated fatty acids in prostate cancer. The Prostate. PMID 27197070 DOI: 10.1002/Pros.23205  0.464
2016 Sergeant S, Rahbar E, Chilton FH. Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes. European Journal of Pharmacology. PMID 27083549 DOI: 10.1016/J.Ejphar.2016.04.020  0.54
2015 Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH. Alterations in Levels and Ratios of n-3 and n-6 Polyunsaturated Fatty Acids in the Temporal Cortex and Liver of Vervet Monkeys from Birth to Early Adulthood. Physiology & Behavior. PMID 26705667 DOI: 10.1016/J.Physbeh.2015.12.009  0.473
2015 Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. The British Journal of Nutrition. 1-11. PMID 26615716 DOI: 10.1017/S0007114515004341  0.487
2014 Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH. The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lipids in Health and Disease. 13: 196. PMID 25515553 DOI: 10.1186/1476-511X-13-196  0.445
2014 Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus. 3: 661. PMID 25485197 DOI: 10.1186/2193-1801-3-661  0.303
2014 Mathias RA, Pani V, Chilton FH. Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake. Current Nutrition Reports. 3: 139-148. PMID 24977108 DOI: 10.1007/S13668-014-0079-1  0.446
2014 Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH. Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. The Journal of Biological Chemistry. 289: 22482-9. PMID 24962583 DOI: 10.1074/Jbc.M114.579557  0.485
2014 Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients. 6: 1993-2022. PMID 24853887 DOI: 10.3390/Nu6051993  0.471
2014 Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. Plos One. 9: e97510. PMID 24842322 DOI: 10.1371/Journal.Pone.0097510  0.467
2013 Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids in Health and Disease. 12: 141. PMID 24088297 DOI: 10.1186/1476-511X-12-141  0.751
2013 Kavanagh K, Flynn DM, Jenkins KA, Wilson MD, Chilton FH. Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys Prostaglandins Leukotrienes and Essential Fatty Acids. 89: 39-45. PMID 23664597 DOI: 10.1016/J.Plefa.2013.04.003  0.449
2012 Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH. Adaptive evolution of the FADS gene cluster within Africa. Plos One. 7: e44926. PMID 23028684 DOI: 10.1371/Journal.Pone.0044926  0.412
2012 Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. The British Journal of Nutrition. 107: 547-55. PMID 21733300 DOI: 10.1017/S0007114511003230  0.464
2011 Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, Kubala M, Vaidya D, Suktitipat B, Ziegler JT, Ivester P, Case D, Yanek LR, Freedman BI, Rudock ME, Barnes KC, ... ... Chilton FH, et al. The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans. Bmc Genetics. 12: 50. PMID 21599946 DOI: 10.1186/1471-2156-12-50  0.433
2011 Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA. Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Physiology & Behavior. 104: 222-7. PMID 21256145 DOI: 10.1016/J.Physbeh.2011.01.013  0.312
2010 Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant S, Barnes KC, Chilton FH. FADS genetic variants and ω-6 polyunsaturated fatty acid metabolism in a homogeneous island population Journal of Lipid Research. 51: 2766-2774. PMID 20562440 DOI: 10.1194/Jlr.M008359  0.383
2010 Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH. Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants. Preventing Chronic Disease. 7: A81. PMID 20550839  0.65
2009 Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. The Journal of Biological Chemistry. 284: 15400-7. PMID 19359242 DOI: 10.1074/Jbc.M109.004861  0.74
2009 Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH. Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. American Journal of Respiratory Cell and Molecular Biology. 41: 358-66. PMID 19151322 DOI: 10.1165/Rcmb.2008-0192Oc  0.304
2008 Chilton FH. Regarding favorable and unfavorable PUFA in fish. Journal of the American Dietetic Association. 108: 1614, 1616; author r. PMID 18926120 DOI: 10.1016/J.Jada.2008.08.031  0.318
2008 Weaver KL, Ivester P, Chilton JA, Wilson MD, Pandey P, Chilton FH. The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish. Journal of the American Dietetic Association. 108: 1178-85. PMID 18589026 DOI: 10.1016/J.Jada.2008.04.023  0.747
2008 Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC. Mechanisms by which botanical lipids affect inflammatory disorders. The American Journal of Clinical Nutrition. 87: 498S-503S. PMID 18258646 DOI: 10.1093/Ajcn/87.2.498S  0.499
2007 Weaver KL, Ivester P, Chilton F. Altering in vivo levels of n-6 and n-3 fatty acids in humans modulates the expression of inflammatory genes. The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A61-B  0.738
2006 Monjazeb AM, High KP, Connoy A, Hart LS, Koumenis C, Chilton FH. Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 27: 1950-60. PMID 16704987 DOI: 10.1093/Carcin/Bgl023  0.367
2005 Monjazeb AM, High KP, Koumenis C, Chilton FH. Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cells. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 73: 463-74. PMID 16169197 DOI: 10.1016/J.Plefa.2005.07.009  0.374
2004 Surette ME, Edens M, Chilton FH, Tramposch KM. Dietary echium oil increases plasma and neutrophil long-chain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans. The Journal of Nutrition. 134: 1406-11. PMID 15173404 DOI: 10.1093/Jn/134.6.1406  0.454
2003 Surette ME, Koumenis IL, Edens MB, Tramposch KM, Clayton B, Bowton D, Chilton FH. Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial. Clinical Therapeutics. 25: 972-9. PMID 12852711 DOI: 10.1016/S0149-2918(03)80117-0  0.454
2003 Surette ME, Koumenis IL, Edens MB, Tramposch KM, Chilton FH. Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects. Clinical Therapeutics. 25: 948-71. PMID 12852710 DOI: 10.1016/S0149-2918(03)80116-9  0.485
2002 Monjazeb AM, Clay CE, High KP, Chilton FH. Antineoplastic properties of arachidonic acid and its metabolites. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 66: 5-12. PMID 12051952 DOI: 10.1054/Plef.2001.0334  0.422
2000 Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH. Addition of eicosapentaenoic acid to γ-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans Journal of Nutrition. 130: 1925-1931. PMID 10917903 DOI: 10.1093/Jn/130.8.1925  0.486
1999 Johnson MM, Vaughn B, Triggiani M, Swan DD, Fonteh AN, Chilton FH. Role of arachidonyl triglycerides within lipid bodies in eicosanoid formation by human polymorphonuclear cells. American Journal of Respiratory Cell and Molecular Biology. 21: 253-258. PMID 10423409 DOI: 10.1165/Ajrcmb.21.2.3489  0.42
1999 Surette ME, Fonteh AN, Bernatchez C, Chilton FH. Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells. Carcinogenesis. 20: 757-763. PMID 10334191 DOI: 10.1093/Carcin/20.5.757  0.445
1998 Fonteh AN, Samet JM, Surette M, Reed W, Chilton FH. Mechanisms that account for the selective release of arachidonic acid from intact cells by secretory phospholipase A2. Biochimica Et Biophysica Acta. 1393: 253-66. PMID 9748613 DOI: 10.1016/S0005-2760(98)00079-4  0.31
1998 Seeds MC, Jones DF, Chilton FH, Bass DA. Secretory and cytosolic phospholipases A2 are activated during TNF priming of human neutrophils Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1389: 273-284. PMID 9512652 DOI: 10.1016/S0005-2760(97)00151-3  0.344
1998 Winkler JD, Sung CM, Chabot-Flecher M, Griswold DE, Marshall LA, Chilton FH, Bondinell W, Mayer RJ. Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase. Molecular Pharmacology. 53: 322-9. PMID 9463491 DOI: 10.1124/Mol.53.2.322  0.311
1997 Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH. Dietary Supplementation with γ-Linolenic Acid Alters Fatty Acid Content and Eicosanoid Production in Healthy Humans Journal of Nutrition. 127: 1435-1444. PMID 9237935 DOI: 10.1093/Jn/127.8.1435  0.44
1996 Winkler JD, Sung CM, Marshall LA, Chilton FH. Inhibitors of arachidonate metabolism and effects on PAF production. Advances in Experimental Medicine and Biology. 416: 11-5. PMID 9131119 DOI: 10.1007/978-1-4899-0179-8_3  0.353
1996 Surette ME, Winkler JD, Fonteh AN, Chilton FH. Relationship between arachidonate--phospholipid remodeling and apoptosis. Biochemistry. 35: 9187-96. PMID 8703924 DOI: 10.1021/Bi9530245  0.408
1996 Samet JM, Fonteh AN, Galli SJ, Tsai M, Fasano MB, Chilton FH. Alterations in arachidonic acid metabolism in mouse mast cells induced to undergo maturation in vitro in response to stem cell factor. The Journal of Allergy and Clinical Immunology. 97: 1329-41. PMID 8648030 DOI: 10.1016/S0091-6749(96)70202-6  0.424
1996 Chilton FH, Surette ME, Winkler JD. Arachidonate—Phospholipid Remodeling and Cell Proliferation Advances in Experimental Medicine and Biology. 416: 169-172. DOI: 10.1007/978-1-4899-0179-8_28  0.374
1995 Chilton FH, Fonteh AN, Sung CM, Hickey DM, Torphy TJ, Mayer RJ, Marshall LA, Heravi JD, Winkler JD. Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils. Biochemistry. 34: 5403-10. PMID 7727398 DOI: 10.1021/Bi00016A011  0.308
1995 Ely EW, Seeds MC, Chilton FH, Bass DA. Neutrophil release of arachidonic acid, oxidants, and proteinases: causally related or independent. Biochimica Et Biophysica Acta. 1258: 135-44. PMID 7548176 DOI: 10.1016/0005-2760(95)00110-X  0.418
1995 Fonteh AN, Samet JM, Chilton FH. Regulation of arachidonic acid, eicosanoid, and phospholipase A2 levels in murine mast cells by recombinant stem cell factor. The Journal of Clinical Investigation. 96: 1432-9. PMID 7544805 DOI: 10.1172/Jci118179  0.34
1994 Stadel JM, Hoyle K, Naclerio RM, Roshak A, Chilton FH. Characterization of phospholipase A2 from human nasal lavage. American Journal of Respiratory Cell and Molecular Biology. 11: 108-113. PMID 8018333 DOI: 10.1165/Ajrcmb.11.1.8018333  0.301
1994 Winkler JD, Sung CM, Huang L, Chilton FH. CoA-independent transacylase activity is increased in human neutrophils after treatment with tumor necrosis factor alpha. Biochimica Et Biophysica Acta. 1215: 133-40. PMID 7947995 DOI: 10.1016/0005-2760(94)90102-3  0.344
1993 Chilton FH, Patel M, Fonteh AN, Hubbard WC, Triggiani M. Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production. Influence of duration and dosage. Journal of Clinical Investigation. 91: 115-122. PMID 8380809 DOI: 10.1172/Jci116159  0.522
1992 Winkler JD, Sung CM, Hubbard WC, Chilton FH. Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils. Biochemical Pharmacology. 44: 2055-66. PMID 1449523 DOI: 10.1016/0006-2952(92)90109-V  0.391
1991 Triggiani M, Warner JA, Schleimer RP, Chilton FH. 409 Synthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in human inflammatory cells The Journal of Allergy and Clinical Immunology. 87: 242. DOI: 10.1016/0091-6749(91)91692-M  0.322
1987 Swendsen CL, Chilton FH, O'Flaherty JT, Suries JR, Piantadosi C, Waite M, Wykle RL. Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 919: 79-89. PMID 3105590 DOI: 10.1016/0005-2760(87)90220-7  0.4
1983 Swendsen CL, Ellis JM, Chilton FH, O'Flaherty JT, Wykle RL. 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. Biochemical and Biophysical Research Communications. 113: 72-9. PMID 6407484 DOI: 10.1016/0006-291X(83)90433-3  0.358
1983 Walsh CE, Dechatelet LR, Chilton FH, Wykle RL, Waite M. Mechanism of arachidonic acid release in human polymorphonuclear leukocytes. Biochimica Et Biophysica Acta. 750: 32-40. PMID 6402027 DOI: 10.1016/0005-2760(83)90201-1  0.417
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