| Year |
Citation |
Score |
| 2023 |
Witman N, Zhou C, Häneke T, Xiao Y, Huang X, Rohner E, Sohlmér J, Grote Beverborg N, Chien KR, Sahara M. Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development. Nature Communications. 14: 5435. PMID 37669989 DOI: 10.1038/s41467-023-41305-7 |
0.36 |
|
| 2022 |
De Genst E, Foo KS, Xiao Y, Rohner E, de Vries E, Sohlmér J, Witman N, Hidalgo A, Kolstad TRS, Louch WE, Pehrsson S, Park A, Ikeda Y, Li X, Mayr LM, ... ... Chien KR, et al. Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure. Nature Communications. 13: 3018. PMID 35641497 DOI: 10.1038/s41467-022-29703-9 |
0.314 |
|
| 2022 |
Eroglu E, Yen CYT, Tsoi YL, Witman N, Elewa A, Joven Araus A, Wang H, Szattler T, Umeano CH, Sohlmér J, Goedel A, Simon A, Chien KR. Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders. Nature Cell Biology. 24: 645-658. PMID 35550612 DOI: 10.1038/s41556-022-00902-2 |
0.376 |
|
| 2022 |
Poch CM, Foo KS, De Angelis MT, Jennbacken K, Santamaria G, Bähr A, Wang QD, Reiter F, Hornaschewitz N, Zawada D, Bozoglu T, My I, Meier A, Dorn T, Hege S, ... ... Chien KR, et al. Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors. Nature Cell Biology. 24: 659-671. PMID 35550611 DOI: 10.1038/s41556-022-00899-8 |
0.372 |
|
| 2021 |
Tang CSM, Mononen M, Lam WY, Jin SC, Zhuang X, Garcia-Barcelo MM, Lin Q, Yang Y, Sahara M, Eroglu E, Chien KR, Hong H, Tam PK, Gruber PJ. Sequencing of a Chinese tetralogy of fallot cohort reveals clustering mutations in myogenic heart progenitors. Jci Insight. PMID 34905512 DOI: 10.1172/jci.insight.152198 |
0.379 |
|
| 2021 |
Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, ... ... Chien KR, et al. Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy. Nature Communications. 12: 5180. PMID 34462437 DOI: 10.1038/s41467-021-25439-0 |
0.351 |
|
| 2021 |
Eroglu E, Schell JP, Chien KR. PHF7 directs cardiac reprogramming. Nature Cell Biology. 23: 440-442. PMID 33941893 DOI: 10.1038/s41556-021-00684-z |
0.323 |
|
| 2021 |
Santoro F, Chien KR, Sahara M. Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis. Star Protocols. 2: 100339. PMID 33644774 DOI: 10.1016/j.xpro.2021.100339 |
0.334 |
|
| 2020 |
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, ... ... Chien KR, et al. Human ISL1 Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33296664 DOI: 10.1016/j.ymthe.2020.11.015 |
0.315 |
|
| 2020 |
Witman N, Zhou C, Beverborg NG, Sahara M, Chien KR. Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51]. Seminars in Cell & Developmental Biology. PMID 33039299 DOI: 10.1016/j.semcdb.2020.09.008 |
0.411 |
|
| 2020 |
Mononen MM, Leung CY, Chien KR. Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage. Stem Cells (Dayton, Ohio). PMID 32497389 DOI: 10.1002/Stem.3236 |
0.497 |
|
| 2020 |
Xu J, Zhou C, Foo KS, Yang R, Xiao Y, Bylund K, Sahara M, Chien KR. Genome-Wide CRISPR Screen Identifies ZIC2 As An Essential Gene That Controls The Cell-Fate of Early Mesodermal Precursors To Human Heart Progenitors. Stem Cells (Dayton, Ohio). PMID 32129551 DOI: 10.1002/Stem.3168 |
0.473 |
|
| 2019 |
Witman N, Zhou C, Grote Beverborg N, Sahara M, Chien KR. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration. Seminars in Cell & Developmental Biology. PMID 31862220 DOI: 10.1016/J.Semcdb.2019.10.011 |
0.516 |
|
| 2019 |
Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W, Fu W, ... Chien KR, et al. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31425721 DOI: 10.1016/J.Jconrel.2019.08.014 |
0.311 |
|
| 2019 |
Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. Regenerating the field of cardiovascular cell therapy. Nature Biotechnology. PMID 30778231 DOI: 10.1038/S41587-019-0042-1 |
0.409 |
|
| 2019 |
Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Developmental Cell. PMID 30713072 DOI: 10.1016/J.Devcel.2019.01.005 |
0.494 |
|
| 2019 |
Chien KR. Reply to 'Re-evaluating sarcoplasmic reticulum function in heart failure' Nature Medicine. 6: 942-3. PMID 10973287 DOI: 10.1038/79595 |
0.37 |
|
| 2019 |
Spaeter D, Hidalgo Gonzalez A, Elbeck Z, Yeh ST, Siga H, Damle SS, Palmer M, Kuo C, Wang QD, Chien KR, Fritsche-Danielson R, Hansson K, Mullick AE, Knoell R. P6348Phospholamban antisense oligonucleotides drive the reversal of cardiac dysfunction and multiple heart failure parameters during murine dilated cardiomyopathy European Heart Journal. 40. DOI: 10.1093/Eurheartj/Ehz746.0944 |
0.416 |
|
| 2018 |
Xu J, Gruber PJ, Chien KR. SMAD4 is essential for human cardiac mesodermal precursor cell formation. Stem Cells (Dayton, Ohio). PMID 30376214 DOI: 10.1002/Stem.2943 |
0.472 |
|
| 2018 |
Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S. Superselective Endovascular Tissue Access Using Trans-Vessel Wall Technique - Feasibility Study for Treatment Applications in Heart, Pancreas, and Kidney in Swine. Journal of Internal Medicine. PMID 30289186 DOI: 10.1111/Joim.12841 |
0.327 |
|
| 2018 |
Carlsson L, Clarke JC, Yen C, Gregoire F, Albery T, Billger M, Egnell AC, Gan LM, Jennbacken K, Johansson E, Linhardt G, Martinsson S, Sadiq MW, Witman N, Wang QD, ... ... Chien KR, et al. Biocompatible, Purified mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine. Molecular Therapy. Methods & Clinical Development. 9: 330-346. PMID 30038937 DOI: 10.1016/J.Omtm.2018.04.003 |
0.394 |
|
| 2018 |
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, ... ... Chien KR, et al. Human ISL1Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29606507 DOI: 10.1016/J.Ymthe.2018.02.012 |
0.465 |
|
| 2017 |
Eroglu E, Chien KR. Heart Regeneration 4.0: Matrix Medicine. Developmental Cell. 42: 7-8. PMID 28697334 DOI: 10.1016/J.Devcel.2017.06.017 |
0.348 |
|
| 2016 |
Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, ... Chien KR, et al. Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nature Communications. 7: 12118. PMID 27431579 DOI: 10.1038/Ncomms12118 |
0.301 |
|
| 2016 |
Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, ... Chien KR, et al. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nature Communications. 7: 10774. PMID 26952167 DOI: 10.1038/Ncomms10774 |
0.425 |
|
| 2015 |
Sahara M, Santoro F, Chien KR. Programming and reprogramming a human heart cell. The Embo Journal. 34: 710-38. PMID 25712211 DOI: 10.15252/Embj.201490563 |
0.486 |
|
| 2015 |
Chien KR, Zangi L, Lui KO. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harbor Perspectives in Medicine. 5: a014035. PMID 25301935 DOI: 10.1101/Cshperspect.A014035 |
0.422 |
|
| 2014 |
Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nature Communications. 5: 5629. PMID 25434740 DOI: 10.1038/Ncomms6629 |
0.306 |
|
| 2014 |
Später D, Hansson EM, Zangi L, Chien KR. How to make a cardiomyocyte. Development (Cambridge, England). 141: 4418-31. PMID 25406392 DOI: 10.1242/Dev.091538 |
0.51 |
|
| 2014 |
Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Research. 24: 1420-32. PMID 25367124 DOI: 10.1038/Cr.2014.142 |
0.404 |
|
| 2014 |
Lian X, Xu J, Li J, Chien KR. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harbor Perspectives in Medicine. 4: a013920. PMID 25237142 DOI: 10.1101/Cshperspect.A013920 |
0.424 |
|
| 2014 |
Lui KO, Zangi L, Chien KR. Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. Stem Cell Research. 13: 693-704. PMID 25043723 DOI: 10.1016/J.Scr.2014.06.007 |
0.479 |
|
| 2014 |
Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, ... ... Chien KR, et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 20: 616-23. PMID 24813252 DOI: 10.1038/Nm.3545 |
0.399 |
|
| 2014 |
Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Research. 24: 820-41. PMID 24810299 DOI: 10.1038/Cr.2014.59 |
0.33 |
|
| 2014 |
Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. Plos One. 9: e93638. PMID 24736439 DOI: 10.1371/Journal.Pone.0093638 |
0.465 |
|
| 2013 |
Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 1: 387-96. PMID 24286027 DOI: 10.1016/J.Stemcr.2013.10.004 |
0.41 |
|
| 2013 |
Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL. Embryonic heart progenitors and cardiogenesis. Cold Spring Harbor Perspectives in Medicine. 3: a013847. PMID 24086063 DOI: 10.1101/Cshperspect.A013847 |
0.5 |
|
| 2013 |
Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Research. 23: 1172-86. PMID 24018375 DOI: 10.1038/Cr.2013.112 |
0.427 |
|
| 2013 |
Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, ... ... Chien KR, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature Biotechnology. 31: 898-907. PMID 24013197 DOI: 10.1038/Nbt.2682 |
0.415 |
|
| 2013 |
Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nature Cell Biology. 15: 1098-106. PMID 23974038 DOI: 10.1038/Ncb2824 |
0.423 |
|
| 2013 |
Chien KR. Regenerative biology: heartbroken embryos heal. Nature. 498: 439-40. PMID 23783518 DOI: 10.1038/Nature12262 |
0.508 |
|
| 2013 |
Soh BS, Wu H, Chien KR. Cardiac regenerative medicine 2.0. Nature Biotechnology. 31: 209-11. PMID 23471068 DOI: 10.1038/Nbt.2524 |
0.431 |
|
| 2012 |
Hansson EM, Chien KR. Reprogramming a broken heart. Cell Stem Cell. 11: 3-4. PMID 22770235 DOI: 10.1016/J.Stem.2012.06.014 |
0.43 |
|
| 2012 |
Xu H, Yi BA, Chien KR. In vivo reprogramming for heart disease. Cell Research. 22: 1521-3. PMID 22751090 DOI: 10.1038/Cr.2012.101 |
0.477 |
|
| 2012 |
Ptaszek LM, Mansour M, Ruskin JN, Chien KR. Towards regenerative therapy for cardiac disease. Lancet (London, England). 379: 933-42. PMID 22405796 DOI: 10.1016/S0140-6736(12)60075-0 |
0.417 |
|
| 2012 |
Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, ... Chien KR, et al. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Research. 22: 142-54. PMID 22064699 DOI: 10.1038/Cr.2011.171 |
0.389 |
|
| 2011 |
Chmielowiec J, Chang YS, Chien KR. A GPS for heart progenitor cell lineages. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1576-8. PMID 21886115 DOI: 10.1038/Mt.2011.158 |
0.442 |
|
| 2011 |
Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, ... ... Chien KR, et al. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circulation Research. 109: 758-69. PMID 21799151 DOI: 10.1161/Circresaha.111.245787 |
0.335 |
|
| 2011 |
Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR. Bioengineering heart muscle: a paradigm for regenerative medicine. Annual Review of Biomedical Engineering. 13: 245-67. PMID 21568715 DOI: 10.1146/Annurev-Bioeng-071910-124701 |
0.421 |
|
| 2011 |
Xu H, Yi BA, Chien KR. Shortcuts to making cardiomyocytes. Nature Cell Biology. 13: 191-3. PMID 21364566 DOI: 10.1038/Ncb0311-191 |
0.422 |
|
| 2011 |
Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovascular Research. 91: 289-99. PMID 21285290 DOI: 10.1093/Cvr/Cvr037 |
0.464 |
|
| 2011 |
Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. Cardiac origin of smooth muscle cells in the inflow tract. Journal of Molecular and Cellular Cardiology. 50: 337-45. PMID 20974149 DOI: 10.1016/J.Yjmcc.2010.10.009 |
0.483 |
|
| 2010 |
Musunuru K, Domian IJ, Chien KR. Stem cell models of cardiac development and disease. Annual Review of Cell and Developmental Biology. 26: 667-87. PMID 20604707 DOI: 10.1146/Annurev-Cellbio-100109-103948 |
0.39 |
|
| 2010 |
Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza J, Hovatta O, Tryggvason K. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nature Biotechnology. 28: 611-5. PMID 20512123 DOI: 10.1038/Nbt.1620 |
0.32 |
|
| 2010 |
Bu L, Gao X, Jiang X, Chien KR, Wang Z. Targeted conditional gene knockout in human embryonic stem cells Cell Research. 20: 379-382. PMID 20142843 DOI: 10.1038/Cr.2010.23 |
0.315 |
|
| 2010 |
Yi BA, Wernet O, Chien KR. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. The Journal of Clinical Investigation. 120: 20-8. PMID 20051633 DOI: 10.1172/Jci40820 |
0.479 |
|
| 2009 |
Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (New York, N.Y.). 326: 426-9. PMID 19833966 DOI: 10.1126/Science.1177350 |
0.459 |
|
| 2009 |
Hansson EM, Lindsay ME, Chien KR. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 5: 364-77. PMID 19796617 DOI: 10.1016/J.Stem.2009.09.004 |
0.334 |
|
| 2009 |
Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 46: 219-25. PMID 19692123 DOI: 10.1016/J.Ceca.2009.07.004 |
0.377 |
|
| 2009 |
Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 460: 113-7. PMID 19571884 DOI: 10.1038/Nature08191 |
0.489 |
|
| 2009 |
Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 89: 983-93. PMID 19546853 DOI: 10.1038/Labinvest.2009.59 |
0.402 |
|
| 2009 |
Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. Journal of Molecular and Cellular Cardiology. 47: 180-7. PMID 19328205 DOI: 10.1016/J.Yjmcc.2009.03.013 |
0.392 |
|
| 2009 |
Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. Prox1 maintains muscle structure and growth in the developing heart. Development (Cambridge, England). 136: 495-505. PMID 19091769 DOI: 10.1242/Dev.030007 |
0.465 |
|
| 2009 |
Risebro CA, Searles RG, Melville AAD, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. Erratum: Prox1 maintains muscle structure and growth in the developing heart (Development (2008) vol. 136 (495-505)) Development. 136. DOI: 10.1242/Dev.034264 |
0.36 |
|
| 2009 |
Chien K. S13-01 Master heart progenitor cells Mechanisms of Development. 126. DOI: 10.1016/J.Mod.2009.06.1024 |
0.426 |
|
| 2008 |
Nakano A, Nakano H, Chien KR. Multipotent Islet-1 cardiovascular progenitors in development and disease Cold Spring Harbor Symposia On Quantitative Biology. 73: 297-306. PMID 19204066 DOI: 10.1101/Sqb.2008.73.055 |
0.49 |
|
| 2008 |
Chien KR, Domian IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science (New York, N.Y.). 322: 1494-7. PMID 19056974 DOI: 10.1126/Science.1163267 |
0.479 |
|
| 2008 |
Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, ... Chien KR, et al. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circulation Research. 103: 580-90. PMID 18689573 DOI: 10.1161/Circresaha.108.171835 |
0.456 |
|
| 2008 |
Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 454: 109-13. PMID 18568026 DOI: 10.1038/Nature07060 |
0.513 |
|
| 2008 |
Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. American Journal of Physiology. Heart and Circulatory Physiology. 295: H509-21. PMID 18539757 DOI: 10.1152/Ajpheart.00368.2008 |
0.433 |
|
| 2008 |
Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, ... ... Chien KR, et al. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Human Molecular Genetics. 17: 2753-65. PMID 18505755 DOI: 10.1093/Hmg/Ddn160 |
0.363 |
|
| 2008 |
Chien KR. Regenerative medicine and human models of human disease. Nature. 453: 302-5. PMID 18480810 DOI: 10.1038/Nature07037 |
0.302 |
|
| 2008 |
Martin-Puig S, Wang Z, Chien KR. Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors Cell Stem Cell. 2: 320-331. PMID 18397752 DOI: 10.1016/J.Stem.2008.03.010 |
0.486 |
|
| 2008 |
Wu SM, Chien KR, Mummery C. Origins and fates of cardiovascular progenitor cells. Cell. 132: 537-43. PMID 18295570 DOI: 10.1016/J.Cell.2008.02.002 |
0.455 |
|
| 2008 |
Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology. 26: 313-5. PMID 18278034 DOI: 10.1038/Nbt1383 |
0.31 |
|
| 2008 |
Ikeda Y, Hoshijima M, Chien KR. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda, Md.). 23: 6-16. PMID 18268360 DOI: 10.1152/Physiol.00033.2007 |
0.409 |
|
| 2008 |
Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. Identification of cardiac-specific myosin light chain kinase. Circulation Research. 102: 571-80. PMID 18202317 DOI: 10.1161/Circresaha.107.161687 |
0.454 |
|
| 2008 |
Kaye DM, Hoshijima M, Chien KR. Reversing advanced heart failure by targeting Ca2+ cycling. Annual Review of Medicine. 59: 13-28. PMID 18186701 DOI: 10.1146/Annurev.Med.59.052407.103237 |
0.415 |
|
| 2008 |
Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages? Development (Cambridge, England). 135: 193-205. PMID 18156162 DOI: 10.1242/Dev.001883 |
0.484 |
|
| 2008 |
Meltzer A, Houser S, Madsen J, Chien K, Cochrane M, Allan J, Rosengard B. 474: Identification of Cells Expressing the Isl1 Cardiac Progenitor Marker in Miniature Swine The Journal of Heart and Lung Transplantation. 27: S230-S231. DOI: 10.1016/J.Healun.2007.11.487 |
0.347 |
|
| 2008 |
Amand TRS, Lu JT, Chien KR. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Foundation Symposium. 250: 260-275. DOI: 10.1002/0470868066.Ch16 |
0.482 |
|
| 2007 |
Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, ... ... Chien KR, et al. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 1: 165-79. PMID 18371348 DOI: 10.1016/J.Stem.2007.05.018 |
0.318 |
|
| 2007 |
Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circulation Journal : Official Journal of the Japanese Circulation Society. 71: 1958-64. PMID 18037754 DOI: 10.1253/Circj.71.1958 |
0.474 |
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| 2007 |
Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, ... ... Chien KR, et al. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 116: 515-25. PMID 17646580 DOI: 10.1161/Circulationaha.107.689984 |
0.343 |
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| 2007 |
Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. Journal of the American College of Cardiology. 50: 253-60. PMID 17631218 DOI: 10.1016/J.Jacc.2007.03.047 |
0.435 |
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| 2007 |
Chien KR. Molecular medicine: microRNAs and the tell-tale heart. Nature. 447: 389-90. PMID 17522664 DOI: 10.1038/447389A |
0.382 |
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| 2007 |
Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Annals of the New York Academy of Sciences. 1112: 171-88. PMID 17495252 DOI: 10.1016/J.Yjmcc.2007.03.685 |
0.407 |
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| 2007 |
Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, ... ... Chien KR, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 128: 947-59. PMID 17350578 DOI: 10.1016/J.Cell.2007.01.042 |
0.509 |
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| 2007 |
Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Molecular Biology of the Cell. 18: 1723-33. PMID 17332502 DOI: 10.1091/Mbc.E06-09-0815 |
0.329 |
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| 2007 |
Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien KR, Giles WR. Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. Cardiovascular Research. 73: 739-49. PMID 17289005 DOI: 10.1016/J.Cardiores.2006.11.034 |
0.36 |
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| 2007 |
Muller O, Pradervand S, Berger S, Centeno G, Milet A, Nicod P, Pedrazzini T, Tronche F, Schütz G, Chien K, Rossier BC, Firsov D. Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. Genomics. 89: 370-7. PMID 17174066 DOI: 10.1016/J.Ygeno.2006.11.001 |
0.35 |
|
| 2007 |
Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 445: 177-82. PMID 17108969 DOI: 10.1038/Nature05383 |
0.445 |
|
| 2007 |
Laugwitz K, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin L, Cai C, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Erratum: Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages Nature. 446: 934-934. DOI: 10.1038/Nature05790 |
0.7 |
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| 2007 |
Andersson KB, Finsen AV, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. WITHDRAWN: Heart function in adult cardiac Serca2null mice Journal of Molecular and Cellular Cardiology. DOI: 10.1016/J.Yjmcc.2007.03.841 |
0.444 |
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| 2007 |
Andersson KB, Finsen AV, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Heart function in adult cardiac Serca2null mice Journal of Molecular and Cellular Cardiology. 42: S106. DOI: 10.1016/J.Yjmcc.2007.03.237 |
0.444 |
|
| 2006 |
Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 127: 1151-65. PMID 17123592 DOI: 10.1016/J.Cell.2006.10.029 |
0.751 |
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| 2006 |
Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 114: 2364-73. PMID 17101849 DOI: 10.1161/Circulationaha.106.642454 |
0.353 |
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| 2006 |
Hoshijima M, Knöll R, Pashmforoush M, Chien KR. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. Journal of the American College of Cardiology. 48: A15-23. PMID 17084280 DOI: 10.1016/J.Jacc.2006.06.070 |
0.409 |
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| 2006 |
Chien KR. Beyond small molecule drugs for heart failure: prospects for gene therapy. Novartis Foundation Symposium. 274: 244-56; discussion 2. PMID 17019816 DOI: 10.1002/0470029331.Ch15 |
0.393 |
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| 2006 |
Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circulation Research. 99: 749-57. PMID 16946137 DOI: 10.1161/01.Res.0000243978.15182.C1 |
0.348 |
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| 2006 |
Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. Journal of Leukocyte Biology. 80: 850-61. PMID 16888087 DOI: 10.1189/Jlb.0206097 |
0.356 |
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| 2006 |
Chien KR. Lost and found: cardiac stem cell therapy revisited. The Journal of Clinical Investigation. 116: 1838-40. PMID 16823485 DOI: 10.1172/Jci29050 |
0.471 |
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| 2006 |
Chien KR. Herceptin and the heart--a molecular modifier of cardiac failure. The New England Journal of Medicine. 354: 789-90. PMID 16495390 DOI: 10.1056/Nejmp058315 |
0.367 |
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| 2006 |
St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Developmental Biology. 291: 208-17. PMID 16430881 DOI: 10.1016/J.Ydbio.2005.10.018 |
0.444 |
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| 2006 |
Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. The Journal of Clinical Investigation. 116: 217-27. PMID 16374517 DOI: 10.1172/Jci24497 |
0.43 |
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| 2006 |
Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien KR, Giles WR. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. The Journal of Physiology. 571: 131-46. PMID 16357014 DOI: 10.1113/Jphysiol.2005.101428 |
0.322 |
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| 2006 |
Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. The Journal of Biological Chemistry. 281: 213-20. PMID 16204254 DOI: 10.1074/Jbc.M505061200 |
0.748 |
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| 2005 |
Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proceedings of the National Academy of Sciences of the United States of America. 102: 18455-60. PMID 16352730 DOI: 10.1073/Pnas.0504343102 |
0.788 |
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| 2005 |
Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 39: 241-50. PMID 15978612 DOI: 10.1016/J.Yjmcc.2005.05.006 |
0.393 |
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| 2005 |
Chien KR. Alchemy and the new age of cardiac muscle cell biology. Plos Biology. 3: e131. PMID 15819607 DOI: 10.1371/Journal.Pbio.0030131 |
0.38 |
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| 2005 |
Chien KR, Karsenty G. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 120: 533-44. PMID 15734685 DOI: 10.1016/J.Cell.2005.02.006 |
0.397 |
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| 2005 |
Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 433: 647-53. PMID 15703750 DOI: 10.1038/Nature03215 |
0.76 |
|
| 2005 |
Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. The Journal of Biological Chemistry. 280: 8016-21. PMID 15598648 DOI: 10.1074/Jbc.M412845200 |
0.755 |
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| 2005 |
Kaye DM, Chien K, Hoshijima M, Zsebo K, Power J. 41. High Efficiency, Catheter-Based, Gene Transfer to the Large Animal Heart Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.069 |
0.425 |
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| 2004 |
Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, ... ... Chien KR, et al. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. Journal of the American College of Cardiology. 44: 2192-201. PMID 15582318 DOI: 10.1016/J.Jacc.2004.08.058 |
0.317 |
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| 2004 |
Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, ... ... Chien KR, et al. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Molecular and Cellular Biology. 24: 10611-20. PMID 15572667 DOI: 10.1128/Mcb.24.24.10611-10620.2004 |
0.486 |
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| 2004 |
Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies Biochemical and Biophysical Research Communications. 325: 852-856. PMID 15541368 DOI: 10.1016/J.Bbrc.2004.10.107 |
0.357 |
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| 2004 |
Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, ... ... Chien KR, et al. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. The Embo Journal. 23: 4517-25. PMID 15510217 DOI: 10.1038/Sj.Emboj.7600454 |
0.328 |
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| 2004 |
Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Molecular and Cellular Biology. 24: 9414-23. PMID 15485910 DOI: 10.1128/Mcb.24.21.9414-9423.2004 |
0.446 |
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| 2004 |
Chien KR, Moretti A, Laugwitz KL. Development. ES cells to the rescue. Science (New York, N.Y.). 306: 239-40. PMID 15472069 DOI: 10.1126/Science.1104769 |
0.448 |
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| 2004 |
Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, et al. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. The Journal of Clinical Investigation. 114: 937-43. PMID 15467832 DOI: 10.1172/Jci20317 |
0.493 |
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| 2004 |
Chien KR, Hoshijima M. Unravelling Ras signals in cardiovascular disease. Nature Cell Biology. 6: 807-8. PMID 15340447 DOI: 10.1038/Ncb0904-807 |
0.355 |
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| 2004 |
Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien KR, Sack MN. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovascular Research. 63: 611-6. PMID 15306216 DOI: 10.1016/J.Cardiores.2004.06.019 |
0.441 |
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| 2004 |
Carrier L, Knöll R, Vignier N, Keller DI, Bausero P, Prudhon B, Isnard R, Ambroisine ML, Fiszman M, Ross J, Schwartz K, Chien KR. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovascular Research. 63: 293-304. PMID 15249187 DOI: 10.1016/J.Cardiores.2004.04.009 |
0.366 |
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| 2004 |
Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 117: 373-86. PMID 15109497 DOI: 10.1016/S0092-8674(04)00405-2 |
0.484 |
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| 2004 |
Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (Cambridge, England). 131: 2219-31. PMID 15073151 DOI: 10.1242/Dev.01094 |
0.507 |
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| 2004 |
Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. The Journal of Clinical Investigation. 113: 727-36. PMID 14991071 DOI: 10.1172/Jci18716 |
0.421 |
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| 2004 |
Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proceedings of the National Academy of Sciences of the United States of America. 101: 3697-702. PMID 14990799 DOI: 10.1073/Pnas.0307324101 |
0.438 |
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| 2004 |
Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J, Chien KR, Lederer JW, Wang Y. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart American Journal of Physiology - Heart and Circulatory Physiology. 286: H424-H433. PMID 12969887 DOI: 10.1152/Ajpheart.00110.2003 |
0.383 |
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| 2004 |
Wells RA, Chien KR, Yen P. RXRα Null Haematopoietic Cells Fail To Reconstitute Haematopoiesis in Lethally Irradiated Recipient Mice. Blood. 104: 2669-2669. DOI: 10.1182/Blood.V104.11.2669.2669 |
0.344 |
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| 2004 |
Knöll RH, Hoshijima M, Chien KR. Mechanisms of dilated cardiomyopathies Drug Discovery Today: Disease Mechanisms. 1: 31-36. DOI: 10.1016/J.Ddmec.2004.08.007 |
0.353 |
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| 2004 |
Gourdie RG, Kubalak SW, O'Brien TX, Chien KR, Mikawa T. Development of Cardiac Pacemaking and Conduction System Lineages Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 225-237. DOI: 10.1016/B978-0-7216-9428-3.50016-0 |
0.322 |
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| 2003 |
Knöll R, Hoshijima M, Chien K. Cardiac mechanotransduction and implications for heart disease. Journal of Molecular Medicine (Berlin, Germany). 81: 750-6. PMID 14551702 DOI: 10.1007/S00109-003-0488-X |
0.407 |
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| 2003 |
Iwatate M, Gu Y, Dieterle T, Iwanaga Y, Peterson KL, Hoshijima M, Chien KR, Ross J. In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart. Gene Therapy. 10: 1814-20. PMID 12960971 DOI: 10.1038/Sj.Gt.3302077 |
0.371 |
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| 2003 |
St Amand TR, Lu JT, Chien KR. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Foundation Symposium. 250: 260-70; discussion 2. PMID 12956335 |
0.381 |
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| 2003 |
Hoshijima M, Pashmforoush M, Knöll R, Chien KR. The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy: a stress pathway model for heart failure progression. Cold Spring Harbor Symposia On Quantitative Biology. 67: 399-408. PMID 12858565 DOI: 10.1101/Sqb.2002.67.399 |
0.351 |
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| 2003 |
Chien KR, Ross J, Hoshijima M. Calcium and heart failure: the cycle game. Nature Medicine. 9: 508-9. PMID 12724757 DOI: 10.1038/Nm0503-508 |
0.381 |
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| 2003 |
Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling Journal of Biological Chemistry. 278: 9570-9575. PMID 12645548 DOI: 10.1074/Jbc.M213132200 |
0.45 |
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| 2003 |
Cheng CF, Kuo HC, Chien KR. Genetic modifiers of cardiac arrhythmias. Trends in Molecular Medicine. 9: 59-66. PMID 12615039 DOI: 10.1016/S1471-4914(03)00004-2 |
0.371 |
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| 2003 |
Christensen G, Gruber PJ, Wang Y, Chien KR. Embryonic and neonatal cardiac gene transfer in vivo. Methods in Molecular Biology (Clifton, N.J.). 219: 169-78. PMID 12597007 DOI: 10.1385/1-59259-350-X:169 |
0.405 |
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| 2003 |
Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. The Journal of Clinical Investigation. 111: 469-78. PMID 12588885 DOI: 10.1172/Jci16491 |
0.415 |
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| 2003 |
Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnology and Bioengineering. 81: 578-87. PMID 12514807 DOI: 10.1002/Bit.10506 |
0.337 |
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| 2003 |
Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, et al. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. The Embo Journal. 22: 216-24. PMID 12514127 DOI: 10.1093/Emboj/Cdg032 |
0.344 |
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| 2003 |
Ruiz-Lozano P, Chien KR. Cre-constructing the heart. Nature Genetics. 33: 8-9. PMID 12509773 DOI: 10.1038/Ng0103-8 |
0.502 |
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| 2003 |
Ferrer-Martínez A, Ruiz-Lozano P, Chien KR. Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 224: 154-67. PMID 12112469 DOI: 10.1002/Dvdy.10099 |
0.387 |
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| 2003 |
Chien KR. Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies Journal of Clinical Investigation. 111: 1433-1433. DOI: 10.1172/Jci200317612 |
0.321 |
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| 2002 |
Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, ... ... Chien KR, et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 111: 943-55. PMID 12507422 DOI: 10.1016/S0092-8674(02)01226-6 |
0.368 |
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| 2002 |
Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (Cambridge, England). 129: 5827-38. PMID 12421720 DOI: 10.1242/Dev.00164 |
0.403 |
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| 2002 |
Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov HM. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mechanisms of Development. 117: 115-22. PMID 12204252 DOI: 10.1016/S0925-4773(02)00206-X |
0.794 |
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| 2002 |
Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J, Chien KR. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice Proceedings of the National Academy of Sciences of the United States of America. 99: 11375-11380. PMID 12177436 DOI: 10.1073/Pnas.172360799 |
0.362 |
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| 2002 |
Chien KR, Olson EN. Converging pathways and principles in heart development and disease: CV@CSH. Cell. 110: 153-62. PMID 12150924 DOI: 10.1016/S0092-8674(02)00834-6 |
0.334 |
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| 2002 |
Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J, Chien KR. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nature Medicine. 8: 864-71. PMID 12134142 DOI: 10.1038/Nm739 |
0.487 |
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| 2002 |
Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hübner N, Chien KR, Birchmeier C, Garratt AN. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 99: 8880-5. PMID 12072561 DOI: 10.1073/Pnas.122249299 |
0.44 |
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| 2002 |
Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR, Lee KF. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nature Medicine. 8: 459-65. PMID 11984589 DOI: 10.1038/Nm0502-459 |
0.432 |
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| 2002 |
Hoshijima M, Chien KR. Mixed signals in heart failure: cancer rules. The Journal of Clinical Investigation. 109: 849-55. PMID 11927610 DOI: 10.1172/Jci15380 |
0.45 |
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| 2002 |
Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross J. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 105: 502-8. PMID 11815435 DOI: 10.1161/Hc0402.102953 |
0.387 |
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| 2002 |
Ruiz-Lozano P, Nakamura T, Chien KR. [Developmental genes and heart disease]. Revista Espanola De Cardiologia. 54: 1439-45. PMID 11754790 DOI: 10.1016/S0300-8932(01)76527-X |
0.492 |
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| 2002 |
Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell. 107: 801-13. PMID 11747815 DOI: 10.1016/S0092-8674(01)00588-8 |
0.487 |
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| 2002 |
Carrier L, Knöll R, Vignier N, Keller D, Prudhon B, Fiszman M, Ross J, Schwartz K, Chien KR. Targeted inactivation of the murine cardiac myosin-binding protein C gene leads to hypertrophic cardiomyopathy Journal of Molecular and Cellular Cardiology. 34: A15. DOI: 10.1016/S0022-2828(02)90786-8 |
0.374 |
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| 2001 |
Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J, Chien KR. Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. The Journal of Clinical Investigation. 108: 1459-67. PMID 11714737 DOI: 10.1172/Jci13939 |
0.394 |
|
| 2001 |
Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes Nature Medicine. 7: 1236-1240. PMID 11689889 DOI: 10.1038/Nm1101-1236 |
0.312 |
|
| 2001 |
Williams SP, Gerber HP, Giordano FJ, Peale FV, Bernstein LJ, Bunting S, Chien KR, Ferrara N, van Bruggen N. Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice. Journal of Magnetic Resonance Imaging : Jmri. 14: 374-82. PMID 11599061 DOI: 10.1002/Jmri.1197 |
0.413 |
|
| 2001 |
Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. 98: 12283-12288. PMID 11593045 DOI: 10.1073/Pnas.211086598 |
0.438 |
|
| 2001 |
Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proceedings of the National Academy of Sciences of the United States of America. 98: 5780-5. PMID 11331753 DOI: 10.1073/Pnas.091415198 |
0.482 |
|
| 2001 |
Pashmforoush M, Pomiès P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nature Medicine. 7: 591-7. PMID 11329061 DOI: 10.1038/87920 |
0.387 |
|
| 2001 |
Chien KR. To Cre or not to Cre: the next generation of mouse models of human cardiac diseases. Circulation Research. 88: 546-9. PMID 11282885 DOI: 10.1161/01.Res.88.6.546 |
0.39 |
|
| 2001 |
Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlmann H, Fishman GI. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circulation Research. 88: 333-9. PMID 11179202 DOI: 10.1161/01.Res.88.3.333 |
0.471 |
|
| 2000 |
Hongo M, Ryoke T, Schoenfeld J, Hunter J, Dalton N, Clark R, Lowe D, Chien K, Ross J. Effects of growth hormone on cardiac dysfunction and gene expression in genetic murine dilated cardiomyopathy. Basic Research in Cardiology. 95: 431-441. PMID 11192363 DOI: 10.1007/S003950070018 |
0.461 |
|
| 2000 |
Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, ... Chien KR, et al. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 102: 671-82. PMID 11007485 DOI: 10.1016/S0092-8674(00)00089-1 |
0.476 |
|
| 2000 |
Chien KR. Genomic circuits and the integrative biology of cardiac diseases. Nature. 407: 227-32. PMID 11001065 DOI: 10.1038/35025196 |
0.409 |
|
| 2000 |
Chien KR. Meeting Koch's postulates for calcium signaling in cardiac hypertrophy. The Journal of Clinical Investigation. 105: 1339-42. PMID 10811840 DOI: 10.1172/Jci10079 |
0.401 |
|
| 2000 |
Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS. Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. Journal of Molecular and Cellular Cardiology. 32: 839-51. PMID 10775488 DOI: 10.1006/Jmcc.2000.1128 |
0.401 |
|
| 2000 |
Christensen G, Minamisawa S, Gruber PJ, Wang Y, Chien KR. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation. 101: 178-84. PMID 10637206 DOI: 10.1161/01.Cir.101.2.178 |
0.419 |
|
| 2000 |
Hertig CM, Kubalak SW, Wang Y, Chien KR. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis. The Journal of Biological Chemistry. 274: 37362-9. PMID 10601306 DOI: 10.1074/Jbc.274.52.37362 |
0.339 |
|
| 1999 |
Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Kranias EG, Giles WR, Chien KR. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 99: 313-22. PMID 10555147 DOI: 10.1016/S0092-8674(00)81662-1 |
0.455 |
|
| 1999 |
Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM. PPAR gamma is required for placental, cardiac, and adipose tissue development. Molecular Cell. 4: 585-95. PMID 10549290 DOI: 10.1016/S1097-2765(00)80209-9 |
0.416 |
|
| 1999 |
Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy and failure. The New England Journal of Medicine. 341: 1276-83. PMID 10528039 DOI: 10.1056/Nejm199910213411706 |
0.449 |
|
| 1999 |
Knowlton KU, Chien KR. Inflammatory pathways and cardiac repair: the affliction of infarction. Nature Medicine. 5: 1122-3. PMID 10502807 DOI: 10.1038/13441 |
0.331 |
|
| 1999 |
Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallón J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proceedings of the National Academy of Sciences of the United States of America. 96: 11376-81. PMID 10500184 DOI: 10.1073/Pnas.96.20.11376 |
0.329 |
|
| 1999 |
Chien KR. Stress pathways and heart failure. Cell. 98: 555-8. PMID 10490095 DOI: 10.1016/S0092-8674(00)80043-4 |
0.37 |
|
| 1999 |
Nakamura T, Ruiz-Lozano P, Lindner V, Yabe D, Taniwaki M, Furukawa Y, Kobuke K, Tashiro K, Lu Z, Andon NL, Schaub R, Matsumori A, Sasayama S, Chien KR, Honjo T. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. The Journal of Biological Chemistry. 274: 22476-83. PMID 10428823 DOI: 10.1074/Jbc.274.32.22476 |
0.351 |
|
| 1999 |
Sah VP, Minamisawa S, Tam SP, Wu TH, Dorn GW, Ross J, Chien KR, Brown JH. Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. The Journal of Clinical Investigation. 103: 1627-34. PMID 10377168 DOI: 10.1172/Jci6842 |
0.483 |
|
| 1999 |
Chen J, Chien KR. Complexity in simplicity: monogenic disorders and complex cardiomyopathies. The Journal of Clinical Investigation. 103: 1483-5. PMID 10359556 DOI: 10.1172/Jci7297 |
0.346 |
|
| 1999 |
Hirota H, Chen J, Betz UA, Rajewsky K, Gu Y, Ross J, Müller W, Chien KR. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 97: 189-98. PMID 10219240 DOI: 10.1016/S0092-8674(00)80729-1 |
0.478 |
|
| 1999 |
Minamisawa S, Gu Y, Ross J, Chien KR, Chen J. A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy. The Journal of Biological Chemistry. 274: 10066-70. PMID 10187786 DOI: 10.1074/Jbc.274.15.10066 |
0.442 |
|
| 1999 |
Schoenfeld JR, Vasser M, Jhurani P, Ng P, Hunter JJ, Ross J, Chien KR, Lowe DG. Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy. Journal of Molecular and Cellular Cardiology. 30: 2269-80. PMID 9925364 DOI: 10.1006/Jmcc.1998.0787 |
0.44 |
|
| 1999 |
Luo ZD, Wang Y, Werlen G, Camp S, Chien KR, Taylor P. Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation Molecular Pharmacology. 56: 886-894. DOI: 10.1124/Mol.56.5.886 |
0.3 |
|
| 1999 |
Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Ross J, Giles WR, Kranias EG, Chien KR. Genetic complementation identifies phospholamban- sarcoplasmic reticulum Ca ATPase interaction as the primary defect that drives the onset of heart failure in dilated cardiomyopathy Journal of Cardiac Failure. 5: 21. DOI: 10.1016/S1071-9164(99)91421-5 |
0.361 |
|
| 1998 |
Liu X, Hwang H, Cao L, Buckland M, Cunningham A, Chen J, Chien KR, Graham RM, Zhou M. Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proceedings of the National Academy of Sciences of the United States of America. 95: 13024-9. PMID 9789034 DOI: 10.1073/Pnas.95.22.13024 |
0.32 |
|
| 1998 |
Hongo M, Sentianin EM, Tanaka N, Mao L, McKirnan MD, Clark RG, Won W, Chien KR, Ross J. Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction. Journal of Cardiac Failure. 4: 213-24. PMID 9754592 DOI: 10.1016/S1071-9164(98)80008-0 |
0.314 |
|
| 1998 |
Adams JW, Sakata Y, Davis MG, Sah VP, Wang Y, Liggett SB, Chien KR, Brown JH, Dorn GW. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 95: 10140-5. PMID 9707614 DOI: 10.1073/Pnas.95.17.10140 |
0.489 |
|
| 1998 |
Cao L, Zhang L, Ruiz-Lozano P, Yang Q, Chien KR, Graham RM, Zhou M. A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation. The Journal of Biological Chemistry. 273: 21077-83. PMID 9694860 DOI: 10.1074/Jbc.273.33.21077 |
0.309 |
|
| 1998 |
Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 7000-5. PMID 9618528 DOI: 10.1073/Pnas.95.12.7000 |
0.464 |
|
| 1998 |
Hoshijima M, Sah VP, Wang Y, Chien KR, Brown JH. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. The Journal of Biological Chemistry. 273: 7725-30. PMID 9516480 DOI: 10.1074/Jbc.273.13.7725 |
0.376 |
|
| 1998 |
Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. The Journal of Biological Chemistry. 273: 5423-6. PMID 9488659 DOI: 10.1074/Jbc.273.10.5423 |
0.413 |
|
| 1998 |
Wang Y, Huang S, Sah VP, Ross J, Brown JH, Han J, Chien KR. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. The Journal of Biological Chemistry. 273: 2161-8. PMID 9442057 DOI: 10.1074/Jbc.273.4.2161 |
0.362 |
|
| 1998 |
Chen J, Kubalak SW, Minamisawa S, Price RL, Becker KD, Hickey R, Ross J, Chien KR. Selective requirement of myosin light chain 2v in embryonic heart function. The Journal of Biological Chemistry. 273: 1252-6. PMID 9422794 DOI: 10.1074/Jbc.273.2.1252 |
0.393 |
|
| 1998 |
Hongo M, Sekiguchi M, Chien KR, Ross J. Effects of growth hormone on cardiac function in murine model of dilated cardiomyopathy due to disruption of muscle lim protein gene Journal of Cardiac Failure. 4: 110. DOI: 10.1016/S1071-9164(98)90474-2 |
0.386 |
|
| 1997 |
Tanaka N, Mao L, DeLano FA, Sentianin EM, Chien KR, Schmid-Schönbein GW, Ross J. Left ventricular volumes and function in the embryonic mouse heart. The American Journal of Physiology. 273: H1368-76. PMID 9321827 DOI: 10.1152/Ajpheart.1997.273.3.H1368 |
0.43 |
|
| 1997 |
Wollert KC, Chien KR. Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. Journal of Molecular Medicine (Berlin, Germany). 75: 492-501. PMID 9253712 DOI: 10.1007/S001090050134 |
0.444 |
|
| 1997 |
Christensen G, Wang Y, Chien KR. Physiological assessment of complex cardiac phenotypes in genetically engineered mice. The American Journal of Physiology. 272: H2513-24. PMID 9227526 DOI: 10.1152/Ajpheart.1997.272.6.H2513 |
0.495 |
|
| 1997 |
Ramirez MT, Sah VP, Zhao XL, Hunter JJ, Chien KR, Brown JH. The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy. The Journal of Biological Chemistry. 272: 14057-61. PMID 9162028 DOI: 10.1074/Jbc.272.22.14057 |
0.33 |
|
| 1997 |
Harris AN, Ruiz-Lozano P, Chen YF, Sionit P, Yu YT, Lilly B, Olson EN, Chien KR. A novel A/T-rich element mediates ANF gene expression during cardiac myocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 29: 515-25. PMID 9140811 DOI: 10.1006/Jmcc.1996.0295 |
0.445 |
|
| 1997 |
Becker KD, Gottshall KR, Hickey R, Perriard JC, Chien KR. Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly. The Journal of Cell Biology. 137: 131-40. PMID 9105042 DOI: 10.1083/Jcb.137.1.131 |
0.325 |
|
| 1997 |
Ruiz-Lozano P, Doevendans P, Brown A, Gruber PJ, Chien KR. Developmental expression of the murine spliceosome-associated protein mSAP49. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 208: 482-90. PMID 9097020 DOI: 10.1002/(Sici)1097-0177(199704)208:4<482::Aid-Aja4>3.0.Co;2-E |
0.421 |
|
| 1997 |
Chien KR, Shimizu M, Hoshijima M, Minamisawa S, Grace AA. Toward molecular strategies for heart disease--past, present, future. Japanese Circulation Journal. 61: 91-118. PMID 9070966 DOI: 10.1253/Jcj.61.91 |
0.41 |
|
| 1997 |
Cohn JN, Bristow MR, Chien KR, Colucci WS, Frazier OH, Leinwand LA, Lorell BH, Moss AJ, Sonnenblick EH, Walsh RA, Mockrin SC, Reinlib L. Report of the National Heart, Lung, and Blood Institute special emphasis panel on heart failure research Circulation. 95: 766-770. PMID 9054723 DOI: 10.1161/01.Cir.95.4.766 |
0.356 |
|
| 1997 |
Arber S, Hunter JJ, Ross J, Hongo M, Sansig G, Borg J, Perriard JC, Chien KR, Caroni P. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 88: 393-403. PMID 9039266 DOI: 10.1016/S0092-8674(00)81878-4 |
0.477 |
|
| 1997 |
Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. The Journal of Biological Chemistry. 272: 5783-91. PMID 9038192 DOI: 10.1074/Jbc.272.9.5783 |
0.361 |
|
| 1997 |
Sah VP, Hoshijima M, Chien KR, Brown JH. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. The Journal of Biological Chemistry. 271: 31185-90. PMID 8940118 DOI: 10.1074/Jbc.271.49.31185 |
0.351 |
|
| 1997 |
Vitadello M, Vettore S, Lamar E, Chien KR, Gorza L. Neurofilament M mRNA is expressed in conduction system myocytes of the developing and adult rabbit heart. Journal of Molecular and Cellular Cardiology. 28: 1833-44. PMID 8899542 DOI: 10.1006/Jmcc.1996.0176 |
0.38 |
|
| 1997 |
Pennica D, Wood WI, Chien KR. Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. Cytokine & Growth Factor Reviews. 7: 81-91. PMID 8864356 DOI: 10.1016/1359-6101(96)00007-X |
0.357 |
|
| 1996 |
Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Chien KR, Powell-Braxton L. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency Journal of Clinical Investigation. 98: 2648-2655. PMID 8958230 DOI: 10.1172/Jci119086 |
0.345 |
|
| 1996 |
Duerr RL, McKirnan MD, Gim RD, Clark RG, Chien KR, Ross J. Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat. Circulation. 93: 2188-96. PMID 8925588 DOI: 10.1161/01.Cir.93.12.2188 |
0.353 |
|
| 1996 |
Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR. RXRα deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice Journal of Clinical Investigation. 98: 1332-1343. PMID 8823298 DOI: 10.1172/Jci118920 |
0.457 |
|
| 1996 |
Tanaka N, Dalton N, Mao L, Rockman HA, Peterson KL, Gottshall KR, Hunter JJ, Chien KR, Ross J. Transthoracic echocardiography in models of cardiac disease in the mouse Circulation. 94: 1109-1117. PMID 8790053 DOI: 10.1161/01.Cir.94.5.1109 |
0.411 |
|
| 1996 |
Engelmann GL, Worrell RA, Duff RA, Grutkoski PS, Chien KR, Harvey RP. Expression of cardiac muscle markers in rat myocyte cell lines. Molecular and Cellular Biochemistry. 157: 87-91. PMID 8739232 DOI: 10.1007/Bf00227884 |
0.436 |
|
| 1996 |
Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. The Journal of Biological Chemistry. 271: 9535-45. PMID 8621626 DOI: 10.1074/Jbc.271.16.9535 |
0.332 |
|
| 1996 |
Becker KD, Gottshall KR, Chien KR. Strategies for studying cardiovascular phenotypes in genetically manipulated mice. Hypertension (Dallas, Tex. : 1979). 27: 495-501. PMID 8613192 DOI: 10.1161/01.Hyp.27.3.495 |
0.325 |
|
| 1996 |
Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS. Developmental changes in ionic channel activity in the embryonic murine heart. Circulation Research. 78: 15-25. PMID 8603498 DOI: 10.1161/01.Res.78.1.15 |
0.36 |
|
| 1996 |
An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS. Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. Circulation Research. 78: 371-8. PMID 8593695 DOI: 10.1161/01.Res.78.3.371 |
0.313 |
|
| 1996 |
Thorburn J, Carlson M, Mansour SJ, Chien KR, Ahn NG, Thorburn A. Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Molecular Biology of the Cell. 6: 1479-90. PMID 8589450 DOI: 10.1091/Mbc.6.11.1479 |
0.353 |
|
| 1996 |
Gottshall KR, David Becker K, Hunter JJ, Chien KR. A genetic based model of cardiac hypertrophy inMLC-Ras mice Journal of Cardiac Failure. 2: S29-S33. DOI: 10.1016/S1071-9164(96)80056-X |
0.367 |
|
| 1995 |
Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh SM, Darbonne WC, Knutzon DS, Yen R, Chien KR, Baker JB, Wood WI. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 92: 1142-1146. PMID 7862649 DOI: 10.1073/Pnas.92.4.1142 |
0.503 |
|
| 1995 |
Duerr RL, Huang S, Miraliakbar HR, Clark R, Chien KR, Ross J. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. The Journal of Clinical Investigation. 95: 619-27. PMID 7860746 DOI: 10.1172/Jci117706 |
0.385 |
|
| 1995 |
Zou Y, Chien KR. EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene. Molecular and Cellular Biology. 15: 2972-82. PMID 7760795 DOI: 10.1128/Mcb.15.6.2972 |
0.37 |
|
| 1995 |
Lembo G, Hunter JJ, Chien KR. Signaling pathways for cardiac growth and hypertrophy. Recent advances and prospects for growth factor therapy. Annals of the New York Academy of Sciences. 752: 115-27. PMID 7755250 DOI: 10.1111/J.1749-6632.1995.Tb17414.X |
0.345 |
|
| 1995 |
Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium Journal of Clinical Investigation. 96: 1311-1318. PMID 7657806 DOI: 10.1172/Jci118166 |
0.396 |
|
| 1995 |
Zhou MD, Sucov HM, Evans RM, Chien KR. Retinoid-dependent pathways suppress myocardial cell hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 92: 7391-7395. PMID 7638203 DOI: 10.1073/Pnas.92.16.7391 |
0.395 |
|
| 1995 |
Dyson E, Sucov HM, Kubalak SW, Schmid-Schonbein GW, DeLano FA, Evans RM, Ross J, Chien KR. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor α -/- mice Proceedings of the National Academy of Sciences of the United States of America. 92: 7386-7390. PMID 7638202 DOI: 10.1073/Pnas.92.16.7386 |
0.484 |
|
| 1995 |
Grace AA, Chien KR. Congenital long QT syndromes. Toward molecular dissection of arrhythmia substrates. Circulation. 92: 2786-9. PMID 7586240 DOI: 10.1161/01.Cir.92.10.2786 |
0.301 |
|
| 1995 |
Lin MC, Rockman HA, Chien KR. Heart and lung disease in engineered mice Nature Medicine. 1: 749-751. PMID 7585174 DOI: 10.1038/Nm0895-749 |
0.322 |
|
| 1995 |
Chien KR. Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology. The American Journal of Physiology. 269: H755-66. PMID 7573515 DOI: 10.1152/Ajpheart.1995.269.3.H755 |
0.413 |
|
| 1995 |
Hunter JJ, Tanaka N, Rockman HA, Ross J, Chien KR. Ventricular expression of a mlc-2v-ras fusion gene induces cardiac hypertrophy selective diastolic dysfunction in transgenic mice Journal of Biological Chemistry. 270: 23173-23178. PMID 7559464 DOI: 10.1074/Jbc.270.39.23173 |
0.494 |
|
| 1994 |
Lee KJ, Hickey R, Zhu H, Chien KR. Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice Molecular and Cellular Biology. 14: 1220-1229. PMID 8289802 DOI: 10.1128/Mcb.14.2.1220 |
0.397 |
|
| 1994 |
van Bilsen M, Chien KR. Growth and hypertrophy of the heart: towards an understanding of cardiac specific and inducible gene expression. Cardiovascular Research. 27: 1140-9. PMID 8252572 DOI: 10.1093/Cvr/27.7.1140 |
0.47 |
|
| 1994 |
Evans SM, Tai LJ, Tan VP, Newton CB, Chien KR. Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype. Molecular and Cellular Biology. 14: 4269-79. PMID 8196663 DOI: 10.1128/Mcb.14.6.4269 |
0.449 |
|
| 1994 |
Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor Science. 264: 582-586. PMID 8160017 DOI: 10.1126/Science.8160017 |
0.433 |
|
| 1994 |
Rockman HA, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, Ross J, Chien KR. Molecular and physiological alterations in murine ventricular dysfunction Proceedings of the National Academy of Sciences of the United States of America. 91: 2694-2698. PMID 8146176 DOI: 10.1073/Pnas.91.7.2694 |
0.389 |
|
| 1994 |
Navankasattusas S, Sawadogo M, Van Bilsen M, Dang CV, Chien KR. The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements Molecular and Cellular Biology. 14: 7331-7339. PMID 7935447 DOI: 10.1128/Mcb.14.11.7331 |
0.404 |
|
| 1994 |
Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis Genes and Development. 8: 1007-1018. PMID 7926783 DOI: 10.1101/Gad.8.9.1007 |
0.445 |
|
| 1994 |
Pennica D, King KL, Chien KR, Baker JB, Wood WI. Cardiotrophin-1, a novel cytokine that induces cardiac myocyte hypertrophy Cytokine. 6: 577. DOI: 10.1016/1043-4666(94)90304-2 |
0.433 |
|
| 1993 |
O'Brien TX, Lee KJ, Chien KR. Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube Proceedings of the National Academy of Sciences of the United States of America. 90: 5157-5161. PMID 8506363 DOI: 10.1073/Pnas.90.11.5157 |
0.44 |
|
| 1993 |
Chien KR, Zhu H, Knowlton KU, Miller-Hance W, van-Bilsen M, O'Brien TX, Evans SM. Transcriptional regulation during cardiac growth and development. Annual Review of Physiology. 55: 77-95. PMID 8466192 DOI: 10.1146/Annurev.Ph.55.030193.000453 |
0.389 |
|
| 1993 |
Hunter JJ, Zhu H, Lee KJ, Kubalak S, Chien KR. Targeting gene expression to specific cardiovascular cell types in transgenic mice Hypertension. 22: 608-617. PMID 8406667 DOI: 10.1161/01.Hyp.22.4.608 |
0.39 |
|
| 1993 |
Zhu H, Van Nguyen TB, Brown AB, Pourhosseini A, Garcia AV, Van Bilsen M, Chien KR. A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene Molecular and Cellular Biology. 13: 4432-4444. PMID 8321243 DOI: 10.1128/Mcb.13.7.4432 |
0.378 |
|
| 1992 |
Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 3037-46. PMID 1835945 DOI: 10.1096/Fasebj.5.15.1835945 |
0.465 |
|
| 1992 |
Shubeita HE, Thorburn J, Chien KR. Microinjection of antibodies and expression vectors into living myocardial cells. Development of a novel approach to identify candidate genes that regulate cardiac growth and hypertrophy. Circulation. 85: 2236-46. PMID 1534288 DOI: 10.1161/01.Cir.85.6.2236 |
0.429 |
|
| 1992 |
Navankasattusas S, Zhu H, Garcia AV, Evans SM, Chien KR. A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression. Molecular and Cellular Biology. 12: 1469-79. PMID 1532229 DOI: 10.1128/Mcb.12.4.1469 |
0.388 |
|
| 1992 |
Shubeita HE, Martinson EA, Van Bilsen M, Chien KR, Brown JH. Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes Proceedings of the National Academy of Sciences of the United States of America. 89: 1305-1309. PMID 1531537 DOI: 10.1073/Pnas.89.4.1305 |
0.4 |
|
| 1992 |
Franz W, Drem G, Rudolph W, Chien KR, Hofschneidor PH, Kandolf R. Characterization of a cardiac-selective and developmentally upregulated promoter in tranagenic mice Journal of Molecular and Cellular Cardiology. 24. DOI: 10.1016/0022-2828(92)91695-2 |
0.405 |
|
| 1992 |
Zhu H, Navankasattusas S, Garcia AV, Evans SM, Chien KR. Synergistic interaction between a ubiquitous and a distinct muscle factor form an e box independent pathway for cardiac muscle gene expression Journal of Molecular and Cellular Cardiology. 24: 99. DOI: 10.1016/0022-2828(92)90324-S |
0.348 |
|
| 1991 |
O'Brien TX, Hunter JJ, Dyson E, Chien KR. Heart-to-heart. New approaches for gene transfer in the myocardium. Circulation. 83: 2133-6. PMID 2040061 DOI: 10.1161/01.Cir.83.6.2133 |
0.411 |
|
| 1991 |
Zhu H, Garcia AV, Ross RS, Evans SM, Chien KR. A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells. Molecular and Cellular Biology. 11: 2273-81. PMID 1848675 DOI: 10.1128/Mcb.11.4.2273 |
0.484 |
|
| 1991 |
Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 88: 8277-81. PMID 1832775 DOI: 10.1073/Pnas.88.18.8277 |
0.424 |
|
| 1991 |
CHIEN K. Transcriptional regulation of the ANF and MLC-2 genes during cardiac growth and development Journal of Molecular and Cellular Cardiology. 23: S30. DOI: 10.1016/0022-2828(91)91412-K |
0.39 |
|
| 1990 |
Ross RS, Chien KR. Of molecules and myocardium. PCR diagnosis of viral myocarditis in cardiac biopsies. Circulation. 82: 294-5. PMID 2364515 DOI: 10.1161/01.Cir.82.1.294 |
0.357 |
|
| 1990 |
Dunnmon PM, Iwaki K, Henderson SA, Sen A, Chien KR. Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells. Journal of Molecular and Cellular Cardiology. 22: 901-10. PMID 2122001 DOI: 10.1016/0022-2828(90)90121-H |
0.4 |
|
| 1989 |
Sills MN, Xu YC, Baracchini E, Goodman RH, Cooperman SS, Mandel G, Chien KR. Expression of diverse Na+ channel messenger RNAs in rat myocardium. Evidence for a cardiac-specific Na+ channel. The Journal of Clinical Investigation. 84: 331-6. PMID 2544627 DOI: 10.1172/Jci114158 |
0.314 |
|
| 1988 |
Henderson SA, Xu YC, Chien KR. Nucleotide sequence of full length cDNAs encoding rat cardiac myosin light chain-2. Nucleic Acids Research. 16: 4722. PMID 3380697 DOI: 10.1093/Nar/16.10.4722 |
0.305 |
|
| 1987 |
Sen A, Buja LM, Willerson JT, Chien KR. Membrane phospholipid metabolism during myocardial ischaemia: past, present and future. Basic Research in Cardiology. 121-5. PMID 3311000 DOI: 10.1007/978-3-662-08390-1_15 |
0.353 |
|
| 1987 |
SEN A, GERARD R, CHIEN K. High efficiency expression of foreign genes in primary cultures of neonatal rat myocardial cells during alpha adrenergic stimulation: Utility of a novel recombinant human adenovirus vector Journal of Molecular and Cellular Cardiology. 19: S49-S49. DOI: 10.1016/S0022-2828(87)80772-1 |
0.324 |
|
| 1987 |
HENDERSON S, DUNNMON P, LEE H, REYNOLDS R, YUAN D, CHIEN K. Alpha-1 adrenergic stimulation of cardiac gene transcription in cultured neonatal rat myocardial cells: Effects on myosin light chain-2 gene expression Journal of Molecular and Cellular Cardiology. 19: S27-S27. DOI: 10.1016/S0022-2828(87)80706-X |
0.376 |
|
| 1985 |
Chien KR, Sen A, Reynolds R, Chang A, Kim Y, Gunn MD, Buja LM, Willerson JT. Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. The Journal of Clinical Investigation. 75: 1770-80. PMID 3924955 DOI: 10.1172/Jci111889 |
0.314 |
|
| 1985 |
Chien KR, Willerson JT, Buja LM. Phospholipid alterations and membrane injury during myocardial ischemia. Advances in Myocardiology. 5: 347-53. PMID 3881812 DOI: 10.1007/978-1-4757-1287-2_26 |
0.308 |
|
| 1984 |
BURTON K, SEN A, BUJA L, WILLERSON J, CHIEN K. Ischemia induced arachidonate release in the isolated heart Journal of Molecular and Cellular Cardiology. 16: 10-10. DOI: 10.1016/S0022-2828(84)80060-7 |
0.342 |
|
| 1983 |
Chien KR, Han A, White J, Kulkarni P. In vivo esterification of a synthetic 125I-labeled fatty acid into cardiac glycerolipids. The American Journal of Physiology. 245: H693-7. PMID 6624940 DOI: 10.1152/Ajpheart.1983.245.4.H693 |
0.348 |
|
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